No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
399 |
4. Check minimum number of eventsNone |
399 |
5. Include endpointsNone |
399 |
6. Filter based on genotype QC (FinnGen only) |
363 |
Control definitions (FinnGen only)
- Control exclude
- H7_VISUALDISTBLIND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H54
- Name in latin
- Amaurosis unius oculi
Similar endpoints
↥List of similar endpoints to
Blindness, monocular
based on the number of shared cases.
Similar with more cases:
- Visual impairment including blindness (binocular or monocular)
- Visual disturbances and blindness
- Diseases of the eye and adnexa
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2797 | 1353 | 1421 |
| Only index persons | 2501 | 1233 | 1268 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.04 |
| Only index persons | 0.05 | 0.05 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 68.28 | 72.20 | 64.44 |
| Only index persons | 67.17 | 71.56 | 62.91 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 363 | 188 | 175 |
| Unadjusted period prevalence (%) | 0.07 | 0.07 | 0.08 |
| Median age at first event (years) | 67.84 | 65.29 | 70.59 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 372
- Matched controls
- 3720
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H54.4
ICD-10 Finland
Blindness, monocular
+∞
307.7
371
*
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
54.8
103.8
60
13
S01ED51
ATC
timolol, combinations; ophthalmic
8.5
71.7
112
179
XCK00
NOMESCO Finland
Perimetry
9.7
65.3
87
114
S01EC01
ATC
acetazolamide; systemic
17.6
65.3
56
37
S01ED01
ATC
timolol; ophthalmic
12.6
65.0
69
66
114
Kela drug reimbursment
Glaucoma
7.2
62.0
115
219
XCW99
NOMESCO Finland
Other investigative procedure of eye
7.2
59.4
107
197
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
8.8
56.1
79
110
H43.1
ICD-10 Finland
Vitreous haemorrhage
16.4
55.5
49
34
H53.1
ICD-10 Finland
Subjective visual disturbances
16.4
55.5
49
34
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
7.7
45.7
72
113
H33.0
ICD-10 Finland
Retinal detachment with retinal break
11.0
44.9
51
53
S01EA05
ATC
brimonidine; ophthalmic
11.8
42.8
46
44
Z96.1
ICD-10 Finland
Presence of intraocular lens
4.6
42.0
140
433
S01EE01
ATC
latanoprost; ophthalmic
6.6
41.3
76
140
H34.8
ICD-10 Finland
Other retinal vascular occlusions
12.0
40.7
43
40
CKC12
NOMESCO Finland
Photocoagulation of retina
8.5
34.8
48
64
CKD40
NOMESCO Finland
Endophotocoagulation of retina
13.9
33.6
32
25
XCK10
NOMESCO Finland
Photography of fundus of eye
5.0
33.5
85
208
WX140
NOMESCO Finland
Parabulbar anesthesy
6.6
32.2
57
100
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.0
32.1
120
394
S01EC04
ATC
brinzolamide; ophthalmic
6.9
31.4
52
85
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
3.5
30.7
233
1200
H16.0
ICD-10 Finland
Corneal ulcer
6.6
30.2
53
92
G45.3
ICD-10 Finland
Amaurosis fugax
11.6
29.9
32
30
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
4.7
29.3
79
202
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
9.2
29.3
37
44
H53.4
ICD-10 Finland
Visual field defects
315.4
29.2
29
*
CS494
NOMESCO Finland
Other visual field testing
10.8
28.7
32
32
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
108.5
28.1
30
*
H34.1
ICD-10 Finland
Central retinal artery occlusion
62.7
25.4
29
5
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
3.1
24.8
201
1034
AA1AD
NOMESCO Finland
CT of head and brain
2.9
22.4
163
781
S01EX03, ,
ATC
9.1
22.2
28
33
H53.9
ICD-10 Finland
Visual disturbance, unspecified
9.3
21.8
27
31
H54.0
ICD-10 Finland
Blindness, binocular
+∞
21.0
20
*
H44.5
ICD-10 Finland
Degenerated conditions of globe
116.6
20.8
22
*
H54.1
ICD-10 Finland
Severe visual impairment, binocular
+∞
20.0
19
*
H47.2
ICD-10 Finland
Optic atrophy
210.7
19.7
20
*
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
33.4
19.5
25
8
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
8.3
18.5
25
32
CKD15
NOMESCO Finland
Injection of vitreous substitute
38.8
17.8
22
6
XCD10
NOMESCO Finland
Electrophysiological examination of eye
7.5
17.6
26
37
S01BA01
ATC
dexamethasone; ophthalmic
6.0
16.3
30
54
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
5.2
16.2
35
73
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
4.2
15.7
44
114
Z3229
NOMESCO Finland
Other healthcare associate professional
3.5
15.6
58
184
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
5.3
15.3
32
65
A10AA01, ,
ATC
6.3
15.0
26
44
S01FA01
ATC
atropine; ophthalmic
33.2
14.9
19
6
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
5.6
14.9
29
55
S01EC03
ATC
dorzolamide; ophthalmic
12.6
14.8
26
22
CHF15
NOMESCO Finland
Cryotherapy of ciliary body
+∞
14.7
14
*
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.9
14.6
84
344
S01EE05
ATC
tafluprost; ophthalmic
5.2
14.5
31
64
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.3
14.5
183
1087
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
28.5
14.4
19
7
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
23.4
14.4
20
9
H57.1
ICD-10 Finland
Ocular pain
5.3
14.3
30
61
H54.5
ICD-10 Finland
Severe visual impairment, monocular
31.4
14.0
18
6
H27.0
ICD-10 Finland
Aphakia
55.5
13.9
16
*
S01EC54
ATC
brinzolamide, combinations; ophthalmic
12.7
13.8
24
20
Z97.0
ICD-10 Finland
Presence of artificial eye
78.1
13.7
15
*
H26.4
ICD-10 Finland
After-cataract
3.0
13.6
69
263
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.2
13.6
61
217
A10AA02, ,
ATC
5.0
13.5
30
64
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
4.1
13.4
39
104
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.3
13.4
212
1371
A10AB01
ATC
insulin (human); parenteral
4.9
13.3
30
65
XCH00
NOMESCO Finland
Eye pressure measurement
4.5
13.3
34
82
ZXA05
NOMESCO Finland
Left side
2.4
13.0
125
653
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
72.4
12.7
14
*
H3603, E103,
ICD-10 Finland
33.3
12.7
16
5
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
6.5
12.6
21
34
TCA15
NOMESCO Finland
Retrobulbar therapeutic injection into orbit
+∞
12.6
12
*
H26.2
ICD-10 Finland
Complicated cataract
15.0
12.4
20
14
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.6
12.3
44
135
H47.0
ICD-10 Finland
Disorders of optic nerve, not elsewhere classified
39.0
12.3
15
*
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.7
12.3
76
322
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
9.2
12.2
25
29
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
5.5
12.2
24
46
S01EE04
ATC
travoprost; ophthalmic
5.9
12.1
22
39
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
4.1
12.0
35
93
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
17.1
11.8
18
11
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
67.1
11.7
13
*
H46
ICD-10 Finland
Optic neuritis
23.8
11.7
16
7
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
4.9
11.6
26
56
S01EA03
ATC
apraclonidine; ophthalmic
14.2
11.6
19
14
H40.0
ICD-10 Finland
Glaucoma suspect
3.3
11.5
46
152
A10AB05
ATC
insulin aspart; parenteral
3.2
11.4
48
164
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
25.9
11.2
15
6
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.4
11.1
43
139
H18.1
ICD-10 Finland
Bullous keratopathy
44.7
11.0
13
*
A10AC01
ATC
insulin (human); parenteral
3.1
10.9
49
174
H50.1
ICD-10 Finland
Divergent concomitant strabismus
61.8
10.7
12
*
A10AE04
ATC
insulin glargine; parenteral
2.9
10.6
56
217
H33.4
ICD-10 Finland
Traction detachment of retina
+∞
10.5
10
*
CDC40
NOMESCO Finland
Evisceration of eye with insertion of prosthesis
+∞
10.5
10
*
SPAT1360
SPAT
Extensive global examination
3.5
10.4
38
118
H34.2
ICD-10 Finland
Other retinal artery occlusions
19.5
10.3
15
8
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.7
10.3
63
264
H20.1
ICD-10 Finland
Chronic iridocyclitis
15.1
10.1
16
11
CKD20
NOMESCO Finland
Removal of vitreous body substitute
15.1
10.1
16
11
B01AC04
ATC
clopidogrel; oral
2.4
10.0
85
416
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
12.7
9.9
17
14
TCG10
NOMESCO Finland
Removal of sutures from cornea
26.8
9.9
13
5
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
8.2
9.8
21
27
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
3.4
9.6
36
114
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
102.5
9.5
10
*
CDC00
NOMESCO Finland
Enucleation of eye
102.5
9.5
10
*
H25.2
ICD-10 Finland
Senile cataract, morgagnian type
30.9
9.5
12
*
3793A
ICD-9 Finland
Other disorders of eye, Aphakia and other disorders of lens[APHAKIA]
+∞
9.4
9
*
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
14.1
9.3
15
11
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
37.7
9.1
11
*
A12AA04
ATC
calcium carbonate; oral
11.1
8.9
16
15
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
8.8
107
603
H40.9
ICD-10 Finland
Glaucoma, unspecified
5.0
8.7
19
40
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.0
8.7
39
138
H10.9
ICD-10 Finland
Conjunctivitis, unspecified
3.3
8.6
33
106
Z94.7
ICD-10 Finland
Corneal transplant status
28.2
8.5
11
*
37520
ICD-8 Finland
Glaucoma, Secondary
92.1
8.4
9
*
A28
ICPC
Limited function/disability NOS
2.1
8.4
99
549
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.1
8.4
97
534
ZXD05
NOMESCO Finland
Urgent procedure
2.0
8.4
126
763
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
8.8
8.4
17
20
S01ED02
ATC
betaxolol; ophthalmic
8.8
8.4
17
20
A04
ICPC
Weakness/tiredness general
2.3
8.3
74
368
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
14.9
8.3
13
9
L28
ICPC
Limited function/disability (L)
2.1
8.2
93
509
T89
ICPC
Diabetes insulin dependent
3.8
8.2
25
69
CKC15
NOMESCO Finland
Panretinal photocoagulation
12.1
8.1
14
12
C10AA01
ATC
simvastatin; oral
1.9
8.1
178
1221
N03AX14
ATC
levetiracetam; systemic
6.8
8.0
19
29
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
6.8
8.0
19
29
H04.10
ICD-10 Finland
Dry eye syndrome
2.5
7.9
55
244
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
13.4
7.9
13
10
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.3
7.9
64
305
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.3
7.9
30
96
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
2.1
7.8
88
479
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.0
7.8
103
595
S01EE03
ATC
bimatoprost; ophthalmic
4.5
7.8
19
44
Z94.0
ICD-10 Finland
Kidney transplant status
15.4
7.8
12
8
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
46.0
7.7
9
*
SPAT1229
SPAT
Assessment of need for aid
2.8
7.7
41
159
ZXA00
NOMESCO Finland
Right side
1.9
7.7
118
716
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
3.8
7.7
24
67
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.2
7.6
69
344
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
25.6
7.6
10
*
CKW99
NOMESCO Finland
Other operation on choroid, vitreous body and retina
25.6
7.6
10
*
N02BE01
ATC
paracetamol; systemic, rectal
2.7
7.6
337
2909
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.1
7.6
77
403
SPAT1234
SPAT
Support of social functional capacity
3.2
7.5
30
99
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
6.2
7.5
19
32
37872
ICD-8 Finland
Other diseases of eye, Aphakia artefacta, acquisita
81.7
7.4
8
*
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
13.7
7.4
12
9
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
4.0
7.4
21
55
3690A
ICD-9 Finland
Blindness and low vision, Profound impairment, both eyes
+∞
7.3
7
*
N18.0
ICD-10 Finland
End-stage renal disease
16.1
7.3
11
7
N02AA05
ATC
oxycodone; systemic
2.0
7.2
93
531
H18.4
ICD-10 Finland
Corneal degeneration
30.7
7.2
9
*
3610A
ICD-9 Finland
Retinal detachments and defects, Retinal detachment with retinal defect
30.7
7.2
9
*
R2120
NOMESCO Finland
Counselling and guidance concerning rehabilitation services and social security
20.5
7.2
10
5
CKC20
NOMESCO Finland
Cryopexy of undetached retina
20.5
7.2
10
5
A11CC03
ATC
alfacalcidol; systemic
6.2
7.2
18
30
S01EB01
ATC
pilocarpine; ophthalmic
10.3
7.1
13
13
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
3.3
7.0
27
87
A10AB04
ATC
insulin lispro; parenteral
4.1
7.0
19
48
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
4.1
7.0
19
48
H54.7
ICD-10 Finland
Unspecified visual loss
14.1
6.9
11
8
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
14.1
6.9
11
8
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.6
6.9
43
181
TNX92
NOMESCO Finland
Supporting bandage or orthosis of lower limb
6.9
6.9
16
24
XCD20
NOMESCO Finland
Photoangiography of eye
6.3
6.9
17
28
F29
ICPC
Eye symptom/complaint other
2.4
6.8
49
221
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
17.1
6.8
10
6
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
6.1
6.7
17
29
H26.02
ICD-10 Finland
Presenil cataract
6.1
6.7
17
29
SPAT1301
SPAT
No procedures
1.8
6.6
127
823
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.8
6.6
148
1005
S01AX11
ATC
[U] ofloxacin
3.4
6.5
24
75
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.1
6.5
72
387
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.5
6.5
22
65
V03AE01
ATC
polystyrene sulfonate; oral
7.6
6.5
14
19
S01BA07
ATC
fluorometholone; ophthalmic
7.6
6.5
14
19
S05.6
ICD-10 Finland
Penetrating wound of eyeball without foreign body
71.0
6.4
7
*
H21.0
ICD-10 Finland
Hyphaema
14.6
6.4
10
7
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
14.6
6.4
10
7
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
2.7
6.4
35
138
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
5.7
6.4
17
31
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
6.1
6.4
16
27
H25.1
ICD-10 Finland
Senile nuclear cataract
1.8
6.4
136
909
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
18.4
6.3
9
5
S01BA04
ATC
prednisolone; ophthalmic
5.2
6.3
18
36
CDC30
NOMESCO Finland
Evisceration of eye
+∞
6.3
6
*
3711
FHL
Cyclodiateria or cryocoagulation
+∞
6.3
6
*
CHC05
NOMESCO Finland
Iridotomy
6.5
6.2
15
24
G40.9
ICD-10 Finland
Epilepsy, unspecified
3.7
6.1
19
53
H02AB06
ATC
prednisolone; systemic
1.7
6.1
183
1341
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.2
6.1
57
287
127
Kela drug reimbursment
Transplant complication
8.8
6.1
12
14
A10AE06
ATC
insulin degludec; parenteral
3.6
6.1
20
58
B03XA02
ATC
darbepoetin alfa; parenteral
5.3
6.1
17
33
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
10.3
6.1
11
11
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
84
288
3.48
20.25
11.9
6.2
12.36
10.32
mmol/l
1.39
78
276
182
1010
2.57
17.68
2.9
2.1
258.80
207.02
u/l
0.37
172
960
275
1869
2.81
17.35
7.9
5.2
7.34
6.75
mmol/l
3.46
263
1771
240
1557
2.53
16.14
19.1
15.7
1.32
1.28
inr
0.38
207
1312
222
1474
2.26
12.97
13.7
6.6
1.20
1.21
mmol/l
1.04
203
1370
205
1330
2.21
12.53
5.7
4.1
45.16
42.60
ng/l
0.08
172
999
68
274
2.81
12.07
2.4
2.5
15.11
7.33
ug/l
0.32
52
245
51
180
3.12
11.44
6.1
3.6
2.54
1.60
mmol/l
1.00
38
136
90
432
2.43
11.14
12.3
5.1
1.08
1.05
mmol/l
0.45
83
395
175
1105
2.10
11.04
4.1
3.5
3717.62
1520.08
ng/l
0.99
153
954
145
867
2.10
10.44
2.9
2.3
3.44
3.17
mg/l
0.56
122
758
37
118
3.37
9.76
2.3
1.7
—
—
—
0
0
273
2089
2.15
9.69
7.1
4.9
817.40
3267.23
e6/l
—
10
44
228
1635
2.02
9.66
15.2
7.2
1.20
1.21
mmol/l
1.37
204
1426
39
130
3.23
9.59
2.6
1.8
—
—
—
0
0
110
610
2.14
9.50
2.0
1.8
1281.41
1206.22
nmol/l
0.30
86
466
44
159
3.00
9.45
2.0
2.2
1.73
1.52
g/l
0.44
33
147
71
342
2.33
8.57
10.5
7.6
—
—
—
0
0
92
502
2.11
8.15
4.4
2.4
19.00
22.07
%
2.33
84
470
199
1416
1.87
8.05
3.8
3.0
—
—
estimate
—
0
0
98
550
2.06
8.04
3.2
3.4
0.80
0.82
mmol/l
0.46
90
522
95
534
2.05
7.74
4.4
2.4
2.21
2.31
g/l
0.78
87
492
285
2302
2.02
7.57
5.4
4.4
16.85
12.88
mm/h
2.57
263
2145
60
284
2.33
7.50
3.1
2.8
65.20
66.43
g/l
0.61
50
261
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
28
89
3.32
7.43
2.5
3.1
0.41
0.34
iu/ml
0.29
16
51
293
2399
2.04
7.36
10.7
8.0
80.09
78.55
u/l
0.26
276
2272
199
1442
1.82
7.35
7.4
4.6
35.01
35.29
g/l
0.28
181
1358
29
95
3.23
7.33
1.7
1.8
—
—
—
0
0
156
1051
1.83
7.32
2.7
2.6
79.17
64.48
u/l
0.20
146
985
43
178
2.60
7.15
1.7
1.4
—
—
—
0
0
233
1794
1.80
6.81
11.6
9.7
4.28
4.24
e9/l
0.09
208
1587
100
598
1.92
6.73
2.5
1.9
—
—
—
0
0
17
29
6.09
6.69
1.0
1.2
—
—
—
0
0
32
118
2.87
6.63
3.6
3.5
3.57
2.51
ratio
0.20
25
65
13
15
8.93
6.60
1.3
1.9
—
—
—
0
0
95
567
1.91
6.40
4.6
2.4
11.29
12.66
umol/l
0.88
88
530
118
759
1.81
6.25
3.6
2.6
—
—
—
0
0
61
314
2.13
6.19
2.3
1.8
369.65
383.50
nmol/l
0.15
52
296
337
2974
2.42
6.05
28.9
17.4
23.18
24.77
mg/l
0.43
293
2491
222
1721
1.72
5.99
6.1
6.3
10.82
11.88
umol/l
0.90
212
1631
71
392
2.00
5.97
7.8
8.6
0.59
1.17
mmol/l
0.62
58
333
190
1414
1.70
5.94
4.4
3.0
151.37
130.58
ug/l
0.71
174
1317
71
393
2.00
5.92
8.0
8.6
5.01
5.11
kpa
0.37
66
381
342
3048
2.51
5.81
36.3
20.7
139.34
139.62
mmol/l
0.98
333
2994
342
3050
2.50
5.77
36.7
20.9
4.02
3.99
mmol/l
0.84
333
2991
218
1701
1.68
5.56
5.4
4.2
0.00
4.27
estimate
0.50
40
380
62
343
1.97
5.16
9.6
3.2
1.18
2.07
mmol/l
1.52
57
286
117
788
1.71
5.14
3.3
2.7
3.90
5.07
e6/l
1.08
108
725
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
10
12
8.53
5.09
1.1
1.3
—
—
—
0
0
217
1718
1.63
5.01
5.4
4.2
0.00
0.85
estimate
0.50
35
356
148
1066
1.64
5.01
4.5
3.3
6.63
7.45
mmol/l
1.58
118
881
345
3129
2.41
4.88
37.2
22.8
94.35
79.65
umol/l
3.46
337
3098
14
30
4.81
4.73
3.8
2.6
—
—
—
0
0
212
1683
1.60
4.72
5.5
4.2
0.00
0.00
estimate
-0.00
38
369
313
2750
1.87
4.70
6.4
5.2
1.92
1.96
mu/l
0.15
276
2518
273
2309
1.69
4.68
5.2
4.2
15.11
14.92
pmol/l
0.51
238
2110
105
702
1.69
4.68
1.7
1.8
458.97
9828033.52
pmol/l
0.50
86
580
65
380
1.86
4.57
6.3
4.8
32.42
31.91
%
0.15
45
241
144
1053
1.60
4.47
5.3
4.1
16.61
9.95
mg/mmol
0.96
97
651
342
3111
2.23
4.45
17.2
12.2
25.44
25.34
u/l
0.04
331
3027
110
757
1.64
4.35
6.2
4.2
1.02
1.02
kg/l
0.22
74
502
178
1383
1.55
4.17
3.3
2.5
76.20
78.36
nmol/l
0.45
161
1251
134
981
1.57
4.06
5.7
4.3
0.00
0.01
estimate
0.74
34
342
347
3198
2.27
3.97
42.8
26.0
91.73
91.32
fl
0.82
341
3171
347
3198
2.27
3.97
43.0
26.1
248.72
245.97
e9/l
0.28
339
3149
151
1142
1.54
3.94
3.2
3.2
2.34
2.36
mmol/l
0.79
130
1035
347
3200
2.26
3.92
43.6
26.6
39.47
40.10
%
1.38
341
3168
347
3200
2.26
3.92
42.9
26.1
4.36
4.46
e12/l
2.78
339
3139
24
101
2.47
3.90
1.7
1.4
—
—
—
0
0
347
3203
2.24
3.86
43.2
26.3
131.17
134.26
g/l
3.11
341
3172
327
2961
1.86
3.80
6.9
5.9
2.43
2.66
mmol/l
4.70
297
2725
26
116
2.33
3.74
4.5
2.5
25.73
24.45
mmol/l
1.05
26
116
38
200
2.00
3.64
2.2
1.7
—
—
—
0
0
135
1010
1.53
3.64
2.0
1.7
19.19
20.57
nmol/l
0.42
111
845
43
238
1.91
3.57
4.6
2.7
57.96
62.51
ml/min/173m2
0.21
23
100
7
9
7.90
3.57
1.1
1.2
—
—
—
0
0
9
17
5.40
3.53
1.1
1.3
—
—
—
0
0
9
17
5.40
3.53
1.1
1.3
—
—
—
0
0
8
13
6.26
3.52
2.1
2.3
—
—
—
0
0
46
264
1.85
3.43
2.3
1.6
—
—
—
0
0
312
2810
1.68
3.40
9.7
6.6
43.45
39.69
mmol/mol
5.35
282
2628
7
10
7.11
3.37
1.1
1.3
—
—
—
0
0
317
2869
1.71
3.36
6.9
5.2
6.45
6.00
mmol/l
3.08
281
2630
14
48
2.99
3.33
1.2
1.3
—
—
—
0
0
176
1413
1.47
3.27
2.7
2.2
98.35
96.48
pmol/l
0.17
96
743
10
24
4.25
3.21
1.2
1.4
—
—
—
0
0
7
11
6.46
3.20
1.0
1.3
—
—
—
0
0
306
2759
1.61
3.12
5.2
4.3
1.36
1.29
mmol/l
0.83
275
2514
27
133
2.11
3.10
4.3
2.1
2.91
3.00
g/l
0.14
19
123
36
198
1.91
3.06
8.3
2.5
1.22
1.27
%
0.14
36
198
6
8
7.60
3.06
1.0
1.4
—
—
—
0
0
7
12
5.92
3.03
1.0
1.0
1304.86
1311.83
miu/ml
—
7
12
25
122
2.12
2.94
4.4
1.9
9.76
10.29
g/l
0.28
17
111
318
2907
1.65
2.92
6.2
5.1
4.32
4.58
mmol/l
3.95
287
2688
17
72
2.43
2.76
2.2
2.9
140.82
99.58
ug/min
0.24
11
40
160
1293
1.42
2.73
5.4
4.2
14.71
0.03
estimate
0.49
34
308
20
92
2.24
2.72
1.5
1.3
—
—
—
0
0
9
24
3.82
2.69
1.1
1.4
—
—
—
0
0
27
141
1.99
2.68
4.3
2.0
4.47
3.78
g/l
0.43
19
131
27
141
1.99
2.68
4.3
2.0
7.14
7.52
g/l
0.55
19
131
27
141
1.99
2.68
4.3
2.0
4.34
4.33
g/l
0.01
19
131
140
1112
1.42
2.61
4.4
3.4
15.27
108.79
e6/l
0.98
122
866
7
15
4.73
2.61
1.1
1.0
—
—
—
0
0
7
15
4.73
2.61
1.1
1.1
—
—
—
0
0
5
7
7.22
2.55
1.0
1.1
—
—
—
0
0
5
7
7.22
2.55
1.0
1.1
—
—
—
0
0
5
7
7.22
2.55
1.6
2.7
—
—
—
0
0
24
123
2.02
2.51
1.4
1.2
—
—
—
0
0
314
2889
1.56
2.49
6.3
5.0
1.38
1.46
mmol/l
2.55
282
2656
228
1980
1.39
2.46
4.1
3.2
63.48
52.09
u/l
0.89
216
1860
18
83
2.23
2.45
1.6
1.4
211.46
309.43
ug/g
—
5
49
87
641
1.47
2.41
5.4
4.1
474.65
264.54
ng/l
0.45
71
518
5
8
6.32
2.38
1.0
1.0
—
—
—
0
0
11
39
2.87
2.36
2.0
1.8
—
—
—
0
0
108
834
1.42
2.32
3.7
2.8
376.39
354.39
umol/l
1.06
94
727
17
79
2.21
2.28
2.9
3.6
1.43
2.04
index
—
7
48
15
66
2.33
2.27
1.2
1.3
—
—
—
0
0
15
67
2.29
2.20
3.0
1.8
7.88
3.42
iu/l
—
5
25
94
715
1.42
2.19
2.3
1.7
1.73
1.46
mg/l
0.20
70
562
7
19
3.73
2.16
8.6
1.7
975.86
470.69
e6/l
—
7
13
10
38
2.68
2.02
1.1
1.3
—
—
—
0
0
89
680
1.41
2.02
3.1
2.9
2.46
2.46
mmol/l
0.04
76
611
45
300
1.57
1.99
1.8
2.1
0.22
0.22
g/l
0.16
40
286
10
39
2.61
1.95
1.7
1.2
2.80
4.13
u/ml
—
5
16
8
27
3.00
1.94
1.6
3.0
1233.25
1052.59
mg
—
8
27
6
16
3.79
1.94
2.7
1.9
—
—
—
0
0
6
16
3.79
1.94
2.7
1.9
—
—
—
0
0
6
16
3.79
1.94
2.7
1.9
—
—
—
0
0
6
16
3.79
1.94
2.7
1.9
—
—
—
0
0
8
28
2.90
1.87
1.1
1.1
—
—
—
0
0
11
46
2.43
1.87
1.4
1.3
134.60
264.95
u/ml
—
5
22
117
946
1.35
1.86
3.8
3.3
0.26
0.51
e6/l
1.46
100
702
13
59
2.25
1.86
1.2
1.7
—
—
—
0
0
6
17
3.57
1.84
1.0
1.2
—
—
—
0
0
75
567
1.40
1.80
3.8
2.9
0.98
1.20
e6/l
0.17
51
310
11
47
2.38
1.79
1.5
3.3
27.40
21.25
mg/l
—
5
21
128
1056
1.32
1.76
4.0
3.0
31.16
33.79
u/l
0.32
123
999
5
13
3.88
1.72
1.4
3.3
687.80
732.62
u/ml
—
5
13
52
372
1.46
1.68
3.3
4.0
3.06
13.22
ug/l
1.78
39
321
22
127
1.78
1.68
5.0
2.3
1.24
0.85
g/l
0.17
14
111
8
31
2.61
1.67
2.3
1.7
—
—
—
0
0
8
31
2.61
1.67
2.3
1.7
—
—
—
0
0
8
31
2.61
1.67
2.3
1.7
—
—
—
0
0
15
76
2.01
1.66
1.5
1.5
—
—
—
0
0
60
443
1.42
1.65
2.2
1.9
—
—
—
0
0
27
170
1.63
1.54
1.1
1.2
38.40
128.75
u/ml
—
5
65
16
86
1.90
1.53
1.1
1.6
—
—
—
0
0
85
676
1.33
1.49
1.5
1.3
3.97
1.43
u/ml
0.68
26
183
9
37
2.47
1.49
2.2
1.9
—
—
—
0
0
52
382
1.42
1.48
2.3
2.6
10.51
8.35
umol/l
0.41
47
331
10
45
2.26
1.47
1.6
1.4
—
—
—
0
0
121
1017
1.28
1.41
5.6
5.6
1.65
2.92
ug/l
2.16
107
901
10
47
2.16
1.35
1.6
1.4
—
—
—
0
0
10
47
2.16
1.35
1.6
1.4
—
—
—
0
0
8
34
2.38
1.30
1.0
1.7
—
—
—
0
0
9
44
2.07
1.27
1.7
1.4
—
—
—
0
0
9
45
2.02
1.24
1.7
1.4
—
—
—
0
0
300
2841
1.29
1.14
26.4
17.0
73.86
77.73
ml/min/173m2
1.89
283
2668
13
73
1.81
1.12
1.2
1.7
—
—
—
0
0
7
31
2.28
1.11
1.1
1.3
—
—
—
0
0
5
21
2.40
1.09
1.2
1.2
—
—
—
0
0
9
46
1.98
1.04
1.7
1.4
—
—
—
0
0
53
416
1.32
1.04
2.2
1.9
—
—
—
0
0
5
22
2.29
1.03
1.0
1.1
—
—
—
0
0
13
76
1.74
1.00
1.2
1.6
—
—
—
0
0
6
27
2.24
0.94
1.0
1.3
—
—
—
0
0
6
28
2.16
0.92
1.2
1.1
—
—
—
0
0
13
206
0.62
0.92
1.2
1.9
3.49
3.55
mmol/l
—
7
155
19
127
1.52
0.90
2.9
2.6
—
—
—
0
0
5
105
0.47
0.90
1.4
1.9
4.39
4.42
mg/l
—
5
76
6
29
2.09
0.89
1.2
1.1
—
—
—
0
0
0
24
0.00
0.79
0.0
1.6
—
—
—
0
0
0
24
0.00
0.79
0.0
2.0
—
13.56
—
0
24
0
25
0.00
0.79
0.0
1.0
—
565.56
—
0
16
0
25
0.00
0.79
0.0
1.1
—
43.69
—
0
16
8
48
1.68
0.79
1.3
1.4
0.56
42.01
nmol/l
—
8
41
24
174
1.41
0.79
3.1
4.2
1.02
1.02
ratio
0.11
24
164
11
68
1.64
0.72
1.0
1.1
—
5.13
—
0
9
7
40
1.76
0.71
1.4
1.1
—
—
—
0
0
5
26
1.94
0.71
1.0
1.2
86.80
101.27
pmol/l
—
5
26
13
85
1.55
0.70
1.8
1.4
—
—
—
0
0
13
87
1.51
0.64
1.5
1.2
—
—
—
0
0
12
79
1.54
0.63
1.2
1.3
—
—
—
0
0
5
30
1.68
0.61
1.4
1.5
—
62.00
—
0
5
188
1758
1.14
0.60
2.7
2.9
—
—
—
0
0
0
21
0.00
0.60
0.0
1.6
—
46.61
—
0
21
0
22
0.00
0.59
0.0
1.4
—
187.24
—
0
22
40
329
1.24
0.59
4.1
3.7
—
—
—
0
0
14
98
1.45
0.57
1.8
1.6
—
—
—
0
0
6
38
1.59
0.54
1.2
1.1
—
—
—
0
0
60
523
1.18
0.51
3.8
3.1
1.47
2.28
e6/l
0.74
35
268
10
67
1.51
0.50
1.2
1.4
—
—
—
0
0
13
93
1.41
0.49
2.4
1.5
—
—
—
0
0
101
928
1.12
0.42
3.7
3.7
0.03
0.09
estimate
0.33
34
299
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
131
1225
1.11
0.39
2.3
2.0
1.43
1.36
mmol/l
0.36
113
1019
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
9
68
1.33
0.38
1.0
1.6
—
—
—
0
0
5
37
1.36
0.37
1.0
1.1
—
1.26
—
0
8
10
72
1.40
0.37
2.2
1.8
—
—
—
0
0
9
71
1.27
0.36
1.1
1.3
—
—
—
0
0
15
117
1.29
0.35
2.1
2.1
2.80
5.89
iu/ml
—
5
33
55
609
0.89
0.32
3.0
3.2
0.72
0.83
ug/l
0.53
39
393
17
137
1.25
0.32
1.0
1.0
—
—
—
0
0
6
47
1.28
0.32
1.2
1.2
—
—
—
0
0
12
92
1.31
0.32
1.8
1.7
—
—
—
0
0
47
525
0.88
0.32
1.2
1.3
10.59
7.59
u/ml
0.14
13
202
13
105
1.25
0.25
1.9
1.7
—
—
—
0
0
11
87
1.27
0.24
1.2
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
34
370
0.91
0.16
1.4
1.5
—
—
—
0
0
12
102
1.18
0.15
2.6
1.8
—
—
—
0
0
9
83
1.09
0.14
1.9
1.8
220.67
227.16
pmol/l
—
9
75
8
99
0.80
0.14
2.3
1.8
45.25
41.17
nmol/l
—
8
94
60
571
1.06
0.13
1.2
1.3
68.67
30.79
iu/ml
0.35
20
187
17
153
1.12
0.11
1.8
3.2
45.62
55.82
u/ml
0.16
17
148
25
231
1.09
0.11
1.6
1.9
—
—
—
0
0
83
802
1.04
0.10
5.4
4.7
21.96
21.19
%
0.15
43
391
5
44
1.14
0.10
1.2
1.3
—
—
—
0
0
11
97
1.14
0.09
1.4
1.1
—
—
—
0
0
26
243
1.08
0.09
1.5
1.5
—
—
—
0
0
45
470
0.95
0.08
2.0
1.5
—
—
—
0
0
7
68
1.03
0.08
1.9
1.4
—
—
—
0
0
7
68
1.03
0.08
1.9
1.4
—
—
—
0
0
11
99
1.11
0.06
1.4
1.1
—
—
—
0
0
26
250
1.04
0.03
1.6
2.0
—
—
—
0
0
13
122
1.07
0.02
2.9
1.8
—
—
—
0
0
33
327
1.01
0.00
1.5
1.8
1.70
1.54
%
0.77
26
287
15
146
1.03
0.00
1.3
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
56
0.89
0.00
3.0
3.3
12.80
38.51
u/ml
—
5
56
5
51
0.98
0.00
2.0
2.7
106.40
106.27
mmol/l
—
5
51
5
50
1.00
0.00
2.0
2.7
1.18
1.21
mmol/l
—
5
50
0
6
0.00
-0.00
0.0
2.5
—
79.17
—
0
6
7
69
1.01
-0.00
8.0
2.9
6.76
9.80
pmol/l
—
7
69
5
54
0.92
-0.00
1.2
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
23.01
—
0
8
0
9
0.00
-0.00
0.0
1.0
—
0.21
—
0
9
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.1
—
41.25
—
0
8
Mortality – FinRegistry
↥Association
Association between endpoint H7_BLINDMONOCULAR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_BLINDMONOCULAR | 1.341 [1.11, 1.62] | 0.003 |
| Birth year | 0.995 [0.99, 1.0] | 0.25 |
During the follow-up period (1.1.1998 — 31.12.2019), 434 out of 1186 females with H7_BLINDMONOCULAR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_BLINDMONOCULAR | 1.671 [1.36, 2.06] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 458 out of 1223 males with H7_BLINDMONOCULAR died.
Mortality risk
Mortality risk for people of age
years, who have H7_BLINDMONOCULAR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.173% | 0.358% |
| 5 | 0.869% | 2.093% |
| 10 | 1.878% | 4.866% |
| 15 | 3.93% | 9.27% |
| 20 | 6.913% | 16.066% |
Relationships between endpoints
↥Index endpoint: H7_BLINDMONOCULAR – Blindness, monocular
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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