≡ Risteys
R14

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Other and unspecified neuropathies

DOID Endpoint Browser PheWeb

G6_HERIPOTHUN

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G60.8, G60.9
  • Hospital discharge: ICD-9 — 356[8-9]
  • Cause of death: ICD-10 — G60.8, G60.9
  • Cause of death: ICD-9 — 356[8-9]

2 out of 7 registries used, show all original rules.

173

4. Check minimum number of events

None

173

5. Include endpoints

None

173

6. Filter based on genotype QC (FinnGen only)

157

Control definitions (FinnGen only)

Control exclude
G6_POLYNEU

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1396 595 779
Only index persons 972 439 533
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 55.99 55.26 56.05
Only index persons 49.86 48.73 50.80

-FinnGen-

Key figures

All Female Male
Number of individuals 157 71 86
Unadjusted period prevalence (%) 0.03 0.03 0.04
Median age at first event (years) 53.17 48.25 57.24

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
162
Matched controls
1620
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G60.9
ICD-10 Finland
Hereditary and idiopathic neuropathy, unspecified
+∞
87.7
76
*
G60.8
ICD-10 Finland
Other hereditary and idiopathic neuropathies
+∞
71.2
63
*
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
484.1
65.5
61
*
G60.0
ICD-10 Finland
Hereditary motor and sensory neuropathy
+∞
53.1
48
*
3569X
ICD-9 Finland
Hereditary and idiopathic peripheral neuropathy, Unspecified
+∞
24.6
23
*
G62.8
ICD-10 Finland
Other specified polyneuropathies
+∞
17.0
16
*
N03AE01
ATC
clonazepam; systemic
6.5
13.1
23
40
SPAT1229
SPAT
Assessment of need for aid
5.8
12.9
26
52
Z31.5
ICD-10 Finland
Genetic counselling
5.9
12.7
25
49
3568X
ICD-9 Finland
Hereditary and idiopathic peripheral neuropathy, Other specified idiopathic peripheral neuropathy
+∞
12.7
12
*
Z50.1
ICD-10 Finland
Other physical therapy
6.4
11.8
21
37
N03AX12
ATC
[U] gabapentin; oral
3.6
11.0
44
151
A28
ICPC
Limited function/disability NOS
3.4
10.9
49
181
L28
ICPC
Limited function/disability (L)
3.4
10.6
49
184
N03AX16
ATC
[U] pregabalin
3.1
9.3
52
217
N99
ICPC
Neurological disease other
29.3
8.6
11
*
R1250
NOMESCO Finland
Evaluation of functional capability
9.4
8.5
17
20
M60.8
ICD-10 Finland
Other myositis
94.8
8.5
9
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.9
7.9
25
72
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.3
7.7
33
117
R5110, ,
SPAT
3.8
7.6
25
74
Z01.8
ICD-10 Finland
Other specified special examinations
2.8
7.2
46
204
M60.9
ICD-10 Finland
Myositis, unspecified
23.7
6.7
9
*
N06AA09
ATC
amitriptyline; systemic
3.6
6.7
24
75
W19
ICD-10 Finland
Unspecified fall
3.4
6.7
26
86
N04BC05
ATC
pramipexole; oral
3.9
6.7
21
60
N39.4
ICD-10 Finland
Other specified urinary incontinence
3.6
6.6
23
71
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.9
6.4
35
142
R27.0
ICD-10 Finland
Ataxia, unspecified
27.9
6.3
8
*
G60.3
ICD-10 Finland
Idiopathic progressive neuropathy
+∞
6.3
6
*
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.7
6.1
40
178
Z3226
NOMESCO Finland
Physiotherapist
2.6
6.1
42
192

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
42
190
2.63
6.24
1.5
1.4
466.67
567.83
titre
0.18
12
46
76
482
2.09
4.97
4.7
3.6
13.24
181.88
e6/l
0.68
60
368
69
422
2.11
4.97
4.7
3.0
—
—
—
0
0
25
99
2.80
4.74
2.3
1.9
—
—
—
0
0
118
903
2.13
4.41
6.5
4.6
—
118.47
—
0
15
66
416
1.99
4.24
4.6
3.5
0.14
0.71
e6/l
2.42
56
306
80
544
1.93
4.08
5.4
4.3
72.66
72.31
e6/l
0.00
63
386
54
335
1.92
3.53
4.1
2.7
3.99
4.48
e6/l
0.20
48
303
9
18
5.23
3.42
1.2
1.4
—
—
—
0
0
92
684
1.80
3.30
7.4
6.1
8.81
8.77
%
0.05
87
641
92
684
1.80
3.30
7.4
5.9
0.57
0.66
%
1.00
87
637
7
11
6.59
3.22
1.1
1.4
—
—
—
0
0
16
62
2.75
3.15
3.7
2.2
—
—
—
0
0
91
683
1.76
3.09
7.4
5.9
2.49
2.79
%
0.74
86
637
6
8
7.73
3.08
1.0
1.3
—
—
—
0
0
11
31
3.73
3.05
5.6
6.3
—
—
—
0
0
97
743
1.76
3.05
7.6
5.8
0.60
0.57
e9/l
0.54
87
625
96
734
1.76
3.03
6.0
4.0
0.00
0.00
estimate
-0.00
23
146
97
744
1.76
3.03
7.6
5.8
0.04
0.04
e9/l
0.27
87
627
91
691
1.72
2.90
7.4
5.9
56.52
57.25
%
0.21
86
653
28
147
2.09
2.88
4.6
5.0
7.38
7.38
ph
0.17
21
87
98
761
1.73
2.86
7.6
5.8
2.32
1.89
e9/l
0.42
88
666
68
480
1.72
2.80
6.0
5.7
—
—
—
0
0
92
705
1.71
2.80
6.7
7.3
1.22
1.21
mmol/l
0.22
83
616
104
825
1.73
2.77
9.0
10.6
4.11
4.12
e9/l
0.01
90
704
98
765
1.71
2.77
7.9
6.2
0.17
0.19
e9/l
1.03
87
664
5
6
8.55
2.77
1.0
1.0
151.00
168.00
nmol/l
—
5
6
83
620
1.69
2.76
2.2
2.1
84.25
96.15
pmol/l
2.18
50
318
94
728
1.69
2.72
6.1
4.0
0.00
0.00
estimate
-0.00
23
165
93
719
1.69
2.70
6.1
4.0
0.00
0.00
estimate
-0.00
23
161
95
743
1.67
2.60
5.3
7.7
18.49
11.95
umol/l
0.67
90
709
10
31
3.37
2.56
4.2
2.9
—
—
—
0
0
6
11
5.62
2.56
2.2
7.7
17.97
15.45
%
—
6
11
60
422
1.67
2.44
6.1
4.6
—
—
—
0
0
76
568
1.64
2.44
5.3
3.6
6.36
6.15
ph
0.95
47
313
38
238
1.78
2.33
1.7
1.7
908.08
1174.65
nmol/l
0.83
28
185
35
214
1.81
2.32
8.6
8.0
105.06
104.39
mmol/l
0.28
35
214
54
375
1.66
2.28
2.3
2.1
3.36
2.95
mg/l
0.22
48
326
73
552
1.59
2.17
6.5
3.9
0.00
0.00
estimate
-0.00
20
137
45
302
1.68
2.15
1.9
2.0
1.33
1.63
mg/l
0.32
36
238
81
629
1.58
2.14
4.1
5.2
35.38
35.44
g/l
0.03
76
592
5
11
4.65
1.95
1.8
1.9
45.08
31.05
%
—
5
11
6
16
3.85
1.95
1.0
1.2
—
—
—
0
0
81
639
1.54
1.94
15.8
12.5
0.00
0.00
e9/l
0.52
71
512
81
648
1.50
1.77
5.9
6.5
1.22
1.22
mmol/l
0.06
76
598
5
13
3.93
1.73
1.2
1.1
—
—
—
0
0
59
444
1.52
1.71
2.7
4.0
7.40
7.39
ph
0.63
46
309
45
319
1.57
1.71
6.2
4.0
1.02
1.02
kg/l
0.00
38
207
37
519
0.63
1.69
2.8
3.4
—
—
—
0
0
29
185
1.69
1.66
1.3
1.5
—
—
—
0
0
28
177
1.70
1.66
2.2
1.6
—
—
—
0
0
14
70
2.09
1.65
5.9
4.3
1.02
1.02
ratio
0.85
14
65
39
536
0.64
1.61
2.5
2.2
—
—
—
0
0
35
238
1.60
1.57
3.4
3.5
1.39
2.16
e6/l
0.33
25
116
26
168
1.65
1.43
8.9
8.0
7.40
7.42
ph
0.41
13
100
13
67
2.02
1.43
8.2
5.2
36.69
36.92
°c
0.42
13
67
21
131
1.69
1.31
8.6
9.8
—
—
—
0
0
5
18
2.83
1.29
1.4
1.6
—
—
—
0
0
133
1217
1.52
1.22
5.3
5.1
1.67
1.96
mu/l
3.61
126
1115
6
26
2.36
1.20
2.7
2.9
5.28
4.85
kpa
—
6
26
6
26
2.36
1.20
2.7
2.9
8.17
8.32
kpa
—
6
26
14
80
1.82
1.17
1.2
1.2
—
—
—
0
0
59
473
1.39
1.17
2.4
2.5
—
—
—
0
0
25
169
1.57
1.16
9.0
7.9
1.94
1.08
mmol/l
0.27
20
142
5
20
2.55
1.16
1.0
1.3
—
—
—
0
0
32
229
1.50
1.15
2.4
1.9
—
—
—
0
0
7
31
2.31
1.12
1.1
1.3
—
—
—
0
0
52
411
1.39
1.11
5.4
3.5
0.00
0.00
estimate
-0.00
18
129
35
258
1.45
1.09
3.5
3.3
0.84
0.81
mmol/l
1.05
35
244
26
180
1.53
1.09
1.1
2.0
93.15
120.90
ug/g
0.31
21
147
7
33
2.17
1.07
1.0
1.7
11.74
13.32
mg/l
—
7
33
13
75
1.80
1.06
1.3
1.2
—
—
—
0
0
11
61
1.86
1.01
2.2
1.8
0.23
6.09
ug/l
0.71
11
55
137
1276
1.48
0.99
4.6
5.2
6.08
5.97
mmol/l
0.29
128
1167
148
1401
1.65
0.99
27.2
21.8
65.62
79.11
umol/l
9.96
148
1389
9
50
1.85
0.98
2.8
1.4
25.09
16.49
iu/l
—
9
41
55
447
1.35
0.98
7.3
6.2
—
—
—
0
0
7
37
1.93
0.95
2.4
3.7
7.44
7.42
ph
—
7
37
17
112
1.58
0.89
1.3
1.2
—
—
—
0
0
110
998
1.32
0.87
4.1
4.2
14.61
14.78
pmol/l
0.30
102
908
75
649
1.29
0.84
3.0
2.9
—
—
estimate
—
0
0
9
147
0.59
0.84
1.4
1.6
—
—
—
0
0
6
33
1.85
0.80
1.0
1.5
—
—
—
0
0
0
25
0.00
0.79
0.0
1.2
—
—
—
0
0
0
25
0.00
0.79
0.0
1.2
—
—
—
0
0
16
107
1.55
0.79
3.2
2.2
6.28
6.04
ph
—
9
72
0
27
0.00
0.78
0.0
1.4
—
—
—
0
0
6
34
1.79
0.77
1.0
3.5
53.50
57.29
%
—
6
34
118
1090
1.30
0.76
27.4
21.7
331.95
332.33
g/l
0.18
118
1090
5
25
2.03
0.73
1.2
1.2
—
—
—
0
0
9
57
1.61
0.72
3.0
2.8
—
—
—
0
0
75
659
1.26
0.71
14.3
12.7
1.28
1.24
inr
0.31
64
547
7
42
1.70
0.69
1.1
1.2
—
—
—
0
0
49
411
1.28
0.68
6.1
3.9
0.00
0.00
estimate
-0.00
19
146
7
43
1.66
0.67
1.3
1.1
—
—
—
0
0
139
1322
1.36
0.65
24.2
17.1
25.97
25.07
mg/l
0.13
128
1110
12
79
1.56
0.64
5.0
4.6
—
—
—
0
0
38
311
1.29
0.64
1.5
1.4
2.29
2.70
g/l
0.84
21
183
17
122
1.44
0.63
3.5
4.6
0.40
0.61
%
—
5
42
44
369
1.26
0.61
4.0
4.5
84.84
89.89
%
0.66
44
364
0
20
0.00
0.61
0.0
1.7
—
33.25
—
0
20
73
649
1.23
0.60
2.8
3.1
120.76
128.19
ug/l
0.17
65
605
38
454
0.79
0.60
3.6
3.3
24.57
73.46
mg/l
2.59
28
293
0
22
0.00
0.60
0.0
1.2
—
—
—
0
0
35
288
1.27
0.57
1.6
1.8
484615855.38
423.78
pmol/l
0.49
26
247
10
66
1.55
0.54
1.9
1.8
—
—
—
0
0
63
558
1.21
0.53
4.3
4.0
62.17
44.44
ng/l
0.26
48
416
12
84
1.46
0.51
9.1
4.1
—
—
—
0
0
13
176
0.72
0.49
1.2
1.5
—
—
—
0
0
43
494
0.82
0.47
3.5
3.4
7.27
7.85
mmol/l
0.40
38
407
117
1229
0.83
0.45
4.7
4.3
1.38
1.28
mmol/l
0.76
107
1124
49
430
1.20
0.45
1.7
1.8
21.07
21.24
nmol/l
0.02
44
350
7
51
1.39
0.44
1.0
1.1
—
—
—
0
0
148
1438
1.34
0.42
31.7
25.4
90.88
90.90
fl
0.01
148
1432
148
1438
1.34
0.42
32.2
25.9
38.83
40.38
%
1.77
148
1432
148
1438
1.34
0.42
31.7
25.3
30.16
30.29
pg
0.34
148
1432
148
1438
1.34
0.42
32.1
25.6
132.88
134.99
g/l
0.98
148
1432
0
15
0.00
0.41
0.0
2.2
—
—
—
0
0
0
16
0.00
0.41
0.0
1.7
—
—
—
0
0
0
17
0.00
0.41
0.0
5.5
—
343.29
—
0
17
5
35
1.44
0.39
1.2
2.1
—
3.80
—
0
13
16
125
1.31
0.38
1.8
2.1
0.00
0.11
estimate
—
6
27
22
181
1.25
0.37
1.2
1.3
—
—
—
0
0
9
123
0.72
0.37
1.6
1.6
—
—
—
0
0
21
172
1.25
0.36
1.8
2.9
6.02
5.48
e9/l
0.13
16
145
23
191
1.24
0.36
1.2
1.2
—
—
—
0
0
124
1286
0.85
0.34
5.1
5.1
1.40
1.45
mmol/l
0.50
115
1185
32
277
1.19
0.34
4.7
3.6
52.71
277.06
ng/l
1.27
24
212
35
307
1.18
0.32
5.8
5.3
—
—
—
0
0
26
222
1.20
0.32
1.7
2.3
29.18
29.31
s
0.05
26
214
53
482
1.15
0.31
4.0
3.5
2.35
2.35
mmol/l
0.08
47
437
41
371
1.14
0.26
2.0
3.1
321.03
349.50
umol/l
0.89
35
321
43
470
0.88
0.25
3.9
4.0
5.55
10.45
mg/mmol
1.07
32
295
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
2.3
—
500.50
—
0
6
9
114
0.78
0.20
1.3
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
2.1
—
—
—
0
0
127
1239
1.12
0.19
6.4
6.6
39.36
39.68
mmol/mol
0.13
120
1165
28
253
1.13
0.18
2.1
2.6
11.84
12.95
umol/l
0.30
22
232
5
66
0.75
0.17
1.4
1.5
—
—
—
0
0
5
66
0.75
0.17
1.4
1.5
—
—
—
0
0
5
67
0.74
0.17
1.4
1.5
—
—
—
0
0
126
1288
0.90
0.17
5.3
5.2
4.54
4.54
mmol/l
0.01
117
1195
12
140
0.85
0.16
1.4
1.6
—
—
—
0
0
7
90
0.77
0.15
1.4
1.2
—
125.48
u/ml
—
0
28
15
132
1.15
0.13
4.5
6.8
6.99
9.38
mmol/l
1.26
15
124
36
340
1.08
0.10
1.5
1.3
0.78
1.49
u/ml
—
5
92
5
44
1.14
0.10
1.0
1.2
—
101.25
—
0
8
5
45
1.11
0.10
1.6
2.0
—
—
—
0
0
5
63
0.79
0.08
1.4
1.5
—
—
—
0
0
5
64
0.77
0.08
1.4
1.5
—
—
—
0
0
21
196
1.08
0.07
2.5
2.6
1.38
1.81
%
3.38
16
177
24
226
1.07
0.07
1.4
1.3
0.97
8.38
u/ml
—
7
79
12
132
0.90
0.07
1.4
1.4
—
—
—
0
0
28
266
1.06
0.06
1.5
1.9
—
—
—
0
0
55
534
1.05
0.06
5.9
5.7
2.44
2.66
ug/l
0.11
48
477
33
317
1.05
0.05
3.5
3.3
0.73
0.75
ug/l
0.05
27
209
13
138
0.94
0.02
1.4
1.5
—
—
—
0
0
57
561
1.02
0.02
1.8
1.9
1.38
1.34
mmol/l
0.12
48
463
132
1312
1.03
0.02
5.8
5.9
2.71
2.66
mmol/l
0.29
123
1215
39
398
0.97
0.02
1.5
1.4
—
—
—
0
0
14
147
0.95
0.01
2.1
2.5
60.11
72.38
e9/l
—
9
112
18
173
1.05
0.01
2.2
4.3
22.38
10.54
umol/l
0.43
18
155
137
1363
1.03
0.01
17.6
14.6
—
—
—
0
0
11
114
0.96
0.00
3.6
3.8
—
—
—
0
0
22
219
1.01
0.00
1.2
1.6
—
—
—
0
0
25
252
0.99
0.00
1.6
1.4
20.97
34.38
iu/ml
—
10
82
16
162
0.99
0.00
1.1
1.3
—
—
—
0
0
24
238
1.01
0.00
2.0
2.6
2.21
2.29
g/l
0.21
19
214
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
7
69
1.02
0.00
1.1
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
5
55
0.91
-0.00
1.4
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.8
—
2265.83
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
38.83
—
0
6
0
7
0.00
-0.00
0.0
1.3
—
84.43
—
0
7
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
6.2
—
45.67
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
9.87
—
0
6
12
120
1.00
-0.00
1.7
1.4
—
—
—
0
0
6
61
0.98
-0.00
1.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.4
—
0.59
—
0
7
5
58
0.86
-0.00
1.2
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
1.07
—
0
6

Mortality – FinRegistry

↥

Association

Association between endpoint G6_HERIPOTHUN and mortality.

Females

Parameter HR [95% CI] p-value
G6_HERIPOTHUN 1.949 [1.41, 2.69] < 0.001
Birth year 0.996 [0.99, 1.0] 0.339

During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 327 females with G6_HERIPOTHUN died.

Males

Parameter HR [95% CI] p-value
G6_HERIPOTHUN 1.706 [1.3, 2.23] < 0.001
Birth year 0.989 [0.98, 1.0] 0.051

During the follow-up period (1.1.1998 — 31.12.2019), 92 out of 395 males with G6_HERIPOTHUN died.

Mortality risk

Mortality risk for people of age

years, who have G6_HERIPOTHUN.

N-year risk Females Males
1 0.17% 0.291%
5 1.14% 2.114%
10 2.679% 5.458%
15 5.451% 10.265%
20 9.551% 16.625%

Relationships between endpoints

↥

Index endpoint: G6_HERIPOTHUN – Other and unspecified neuropathies

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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