brain disease: A disease affecting the brain or part of the brain.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
412 |
4. Check minimum number of eventsNone |
412 |
5. Include endpointsNone |
412 |
6. Filter based on genotype QC (FinnGen only) |
367 |
Control definitions (FinnGen only)
- Control exclude
- G6_OTHNEU
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G93
- Name in latin
- Encephalopathia non specificata
Similar endpoints
↥List of similar endpoints to
Encephalopathy
based on the number of shared cases.
Similar with more cases:
- Other neurological diseases
- Condition for Implicit Sepsis (Organ dysfunction codes)
- Condition for Implicit Sepsis (Organ dysfunction codes), including avohilmo
- Neurological diseases
- Neurological diseases, wide definition
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4284 | 1649 | 2575 |
| Only index persons | 2826 | 1169 | 1657 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.05 | 0.07 |
| Only index persons | 0.05 | 0.04 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 60.73 | 60.46 | 60.73 |
| Only index persons | 58.69 | 58.57 | 58.78 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 367 | 143 | 224 |
| Unadjusted period prevalence (%) | 0.08 | 0.05 | 0.10 |
| Median age at first event (years) | 61.09 | 59.27 | 62.26 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 380
- Matched controls
- 3800
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G93.4
ICD-10 Finland
Encephalopathy, unspecified
4503599627370496.0
307.7
350
*
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
43.6
92.0
56
15
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
31.4
90.6
61
23
R18
ICD-10 Finland
Ascites
19.5
70.0
57
34
A07AA11
ATC
rifaximin; oral
583.9
52.8
51
*
A06AD11
ATC
lactulose; oral
5.4
50.6
135
354
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
19.0
50.4
41
24
AA1AD
NOMESCO Finland
CT of head and brain
4.3
42.9
184
685
R41.0
ICD-10 Finland
Disorientation, unspecified
10.4
40.9
48
52
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.9
37.6
184
737
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
6.2
37.2
71
135
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
45.8
33.8
41
10
3483X
ICD-9 Finland
Other conditions of brain, Encephalopathy, unspecified
+∞
32.8
31
*
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
10.9
30.5
34
34
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.2
30.1
100
300
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.7
29.9
130
470
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
10.0
29.6
35
38
C03DA01
ATC
spironolactone; oral
4.1
28.7
98
299
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
5.1
28.6
67
152
N03AX14
ATC
levetiracetam; systemic
9.5
28.5
35
40
R56.8
ICD-10 Finland
Other and unspecified convulsions
6.4
28.0
50
88
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
6.2
27.4
50
90
N03AG01
ATC
valproic acid; systemic, rectal
5.9
27.4
53
101
N17.9
ICD-10 Finland
Acute renal failure, unspecified
6.8
26.4
44
72
TK800
NOMESCO Finland
Hemodialysis
10.4
26.2
30
31
K70.4
ICD-10 Finland
Alcoholic hepatic failure
57.9
23.4
27
5
K72.1
ICD-10 Finland
Chronic hepatic failure
244.1
22.9
23
*
C03CA01
ATC
furosemide; systemic
2.9
22.5
177
881
XA800
NOMESCO Finland
Neuropsychological investigation
6.4
21.8
38
65
F05.9
ICD-10 Finland
Delirium, unspecified
9.0
21.3
27
32
G40.9
ICD-10 Finland
Epilepsy, unspecified
6.5
21.2
36
60
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
27.3
20.7
28
11
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.6
20.7
80
262
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.0
20.4
64
181
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
4.8
20.3
49
113
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.9
20.3
66
192
K72.9
ICD-10 Finland
Hepatic failure, unspecified
38.1
20.1
25
7
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.3
20.0
57
150
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.6
19.7
50
120
JA2AT
NOMESCO Finland
Abdominal puncture with ultrasound guidance
33.3
19.5
25
8
D64.9
ICD-10 Finland
Anaemia, unspecified
3.6
19.5
74
239
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
4.7
19.2
48
114
C07AA05
ATC
propranolol; systemic
3.1
19.0
102
407
N05AH04
ATC
quetiapine; oral
3.1
18.8
95
366
JCA22
NOMESCO Finland
Endoscopic ligature of oesophageal varices
40.7
18.8
23
6
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
8.3
18.5
25
32
K92.0
ICD-10 Finland
Haematemesis
7.4
18.0
27
39
A28
ICPC
Limited function/disability NOS
2.9
17.5
107
457
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.9
17.4
105
445
N05AD01
ATC
haloperidol; systemic
6.1
16.6
30
53
A41.9
ICD-10 Finland
Sepsis, unspecified
5.2
15.5
33
68
A10AB05
ATC
insulin aspart; parenteral
3.7
15.4
53
159
N03AF02
ATC
oxcarbazepine; oral
6.4
15.3
26
43
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
5.7
15.2
29
54
G41.9
ICD-10 Finland
Status epilepticus, unspecified
47.0
15.2
18
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.8
15.0
49
142
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
3.3
14.8
61
206
JJC00
NOMESCO Finland
Allogenic transplantation of liver
83.4
14.7
16
*
K92.1
ICD-10 Finland
Melaena
4.0
14.6
44
120
Z94.4
ICD-10 Finland
Liver transplant status
37.7
14.6
18
5
SPAT1255
SPAT
Intravenous administration of medicine
4.1
14.5
43
116
TAB00
NOMESCO Finland
Lumbar puncture
4.5
14.5
37
89
R53
ICD-10 Finland
Malaise and fatigue
2.5
14.5
120
590
K76.7
ICD-10 Finland
Hepatorenal syndrome
78.0
13.7
15
*
N05AX08
ATC
risperidone; systemic
3.3
13.5
55
184
127
Kela drug reimbursment
Transplant complication
14.5
13.4
22
16
N05AH03
ATC
olanzapine; systemic
4.0
13.2
39
105
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
3.1
13.1
59
210
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
4.8
13.1
30
66
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.1
12.6
58
209
L28
ICPC
Limited function/disability (L)
2.5
12.5
96
451
UJD02
NOMESCO Finland
Gastroscopy
4.2
12.5
34
86
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
3.7
12.5
41
119
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.6
12.3
84
373
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.2
11.8
136
761
G31.2
ICD-10 Finland
Degeneration of nervous system due to alcohol
13.1
11.8
20
16
A10AE04
ATC
insulin glargine; parenteral
2.9
11.7
59
223
N05BA09
ATC
clobazam; oral
23.8
11.7
16
7
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
3.4
11.7
44
140
JN4AD
NOMESCO Finland
Body CT examination
2.8
11.6
67
273
C22.0
ICD-10 Finland
Malignant neoplasm: Liver cell carcinoma
14.2
11.6
19
14
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.3
11.6
121
650
SPAT1229
SPAT
Assessment of need for aid
3.4
11.5
43
136
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.5
11.5
41
126
103
Kela drug reimbursment
Diabetes, insulin-treated
2.2
11.4
133
746
P15
ICPC
Chronic alcohol abuse
5.0
11.4
25
53
N06AX11
ATC
mirtazapine; oral
2.1
10.9
142
830
SPAT1262
SPAT
Handing over of treatment supplies
2.4
10.8
84
395
J01MA02
ATC
ciprofloxacin; systemic
2.1
10.8
167
1040
I85.0
ICD-10 Finland
Oesophageal varices with bleeding
61.8
10.7
12
*
C07AG02
ATC
carvedilol; oral
3.4
10.6
39
122
N02AA05
ATC
oxycodone; systemic
2.3
10.6
97
491
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
3.2
10.5
45
155
L04AA06
ATC
mycophenolic acid; systemic
8.6
10.5
22
27
N03AE01
ATC
clonazepam; systemic
3.7
10.4
34
98
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
4.6
10.4
25
57
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
4.8
10.4
24
53
R50.9
ICD-10 Finland
Fever, unspecified
2.5
10.4
78
361
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.2
10.2
118
655
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
4.8
10.1
23
50
B03BA03
ATC
hydroxocobalamin; parenteral
3.7
10.1
33
95
E87.6
ICD-10 Finland
Hypokalaemia
4.2
9.9
27
68
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
12.6
9.9
17
14
F10.40
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without seizures
12.6
9.9
17
14
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
5.4
9.9
20
39
F10.20
ICD-10 Finland
Alcohol dependence currently independent
7.7
9.8
22
30
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
5.5
9.7
19
36
N03AX12
ATC
[U] gabapentin; oral
2.4
9.7
78
372
WX892
NOMESCO Finland
Monitored bed care
3.0
9.7
44
157
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.4
9.6
73
339
D97
ICPC
Liver disease NOS
15.6
9.6
15
10
N05BA01
ATC
diazepam; systemic, rectal
2.5
9.5
64
281
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.6
9.5
59
249
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
102.5
9.5
10
*
G04.9
ICD-10 Finland
Encephalitis, myelitis and encephalomyelitis, unspecified
102.5
9.5
10
*
W19
ICD-10 Finland
Unspecified fall
2.8
9.4
50
194
K70.1
ICD-10 Finland
Alcoholic hepatitis
22.4
9.4
13
6
R13
ICD-10 Finland
Dysphagia
3.1
9.4
40
137
TPH07
NOMESCO Finland
Cathetrisation of artery
2.6
9.3
59
251
N06AX16
ATC
venlafaxine; oral
2.6
9.3
60
258
Z2445
NOMESCO Finland
Psychologist
4.6
9.2
22
50
TPH04
NOMESCO Finland
Cathetrisation of vein
2.2
9.1
100
541
R11
ICD-10 Finland
Nausea and vomiting
2.9
9.0
46
175
N03AX18
ATC
lacosamide; systemic
19.2
9.0
13
7
K72.0
ICD-10 Finland
Acute and subacute hepatic failure
24.7
9.0
12
5
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.1
8.9
39
136
A86
ICD-10 Finland
Unspecified viral encephalitis
51.2
8.7
10
*
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
4.0
8.7
25
66
WX730
NOMESCO Finland
Conventional respirator
12.0
8.6
15
13
N03AX16
ATC
[U] pregabalin
2.1
8.5
98
539
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.5
8.5
57
249
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
2.9
8.4
40
146
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.2
8.4
80
409
ZX120
NOMESCO Finland
Intravenous
2.7
8.3
48
195
A10AE05
ATC
insulin detemir; parenteral
3.4
8.3
30
93
Z01.8
ICD-10 Finland
Other specified special examinations
2.1
8.3
97
537
F10.25
ICD-10 Finland
Alcohol dependence continuous use
8.4
8.2
17
21
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.2
8.1
76
385
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.3
8.1
66
315
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
22.6
8.1
11
5
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
8.0
200
1422
A10BH05
ATC
linagliptin; oral
3.3
8.0
30
95
N05BA04
ATC
oxazepam; oral
2.0
8.0
107
621
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
3.8
7.9
24
66
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.8
7.8
41
158
A10BA02
ATC
metformin; oral
1.9
7.8
126
779
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.3
7.8
61
286
R1250
NOMESCO Finland
Evaluation of functional capability
4.5
7.8
19
44
G40.4
ICD-10 Finland
Other generalized epilepsy and epileptic syndromes
45.9
7.7
9
*
G41.2
ICD-10 Finland
Complex partial status epilepticus
45.9
7.7
9
*
SPAT1254
SPAT
Administration of medicine
2.3
7.7
66
321
SPAT1216
SPAT
Assessment of functional ability
2.2
7.7
70
349
OAA67, ,
SPAT
0.1
7.7
*
291
K90
ICPC
Stroke/cerebrovascular accident
4.6
7.5
18
41
WX704
NOMESCO Finland
Intubation
2.9
7.5
37
138
R55
ICD-10 Finland
Syncope and collapse
2.4
7.5
54
244
E66.9
ICD-10 Finland
Obesity, unspecified
4.2
7.4
20
50
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
3.8
7.4
23
64
WW500
NOMESCO Finland
Blood transfusion
3.4
7.4
27
84
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.6
7.4
24
69
Z51.5
ICD-10 Finland
Palliative care
2.5
7.4
47
200
N05CD07
ATC
temazepam; oral
2.3
7.4
59
279
N05CF01
ATC
zopiclone; oral
1.9
7.4
133
850
G45.0
ICD-10 Finland
Vertebro-basilar artery syndrome
+∞
7.3
7
*
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
+∞
7.3
7
*
G93.8
ICD-10 Finland
Other specified disorders of brain
+∞
7.3
7
*
K76.9
ICD-10 Finland
Liver disease, unspecified
7.5
7.3
16
22
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
4.6
7.2
17
38
N19
ICD-10 Finland
Unspecified kidney failure
3.5
7.1
25
76
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
4.3
7.1
18
43
L04AD02
ATC
tacrolimus; systemic
10.3
7.1
13
13
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
6.0
7.0
18
31
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.1
6.9
70
364
N05BE01
ATC
buspirone; oral
3.9
6.9
20
53
UJF32
NOMESCO Finland
Coloscopy
1.9
6.9
109
665
L04AD01
ATC
ciclosporin; systemic
8.5
6.9
14
17
Z49.1
ICD-10 Finland
Extracorporeal dialysis
8.5
6.9
14
17
E87.5
ICD-10 Finland
Hyperkalaemia
5.9
6.8
18
32
N99
ICPC
Neurological disease other
11.2
6.8
12
11
F10.30
ICD-10 Finland
Withdrawal symptoms caused by alcohol uncomplicated
11.2
6.8
12
11
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
2.9
6.8
32
116
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
4.4
6.8
17
40
N03AX09
ATC
lamotrigine; oral
3.6
6.8
22
63
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
3.5
6.8
23
68
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
7.4
6.8
15
21
A46
ICD-10 Finland
Erysipelas
2.1
6.7
67
347
N03AF01
ATC
carbamazepine; oral, rectal
3.0
6.7
30
106
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
3.7
6.7
21
59
M04AA01
ATC
allopurinol; systemic
2.1
6.7
65
333
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.5
6.7
23
69
Z2446
NOMESCO Finland
Social worker
2.9
6.6
32
118
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.4
6.6
46
204
N06AB04
ATC
citalopram; systemic
2.0
6.6
80
446
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
6.6
131
858
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.9
6.5
30
108
Z02.7
ICD-10 Finland
Issue of medical certificate
2.7
6.4
36
144
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
3.7
6.4
20
56
R60.0
ICD-10 Finland
Localized oedema
2.2
6.4
59
296
SPAT1215
SPAT
Assessment of need for medical rehabilitation
3.6
6.4
21
61
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
6.1
6.4
16
27
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
6.1
6.4
16
27
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.1
6.3
61
311
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.1
6.3
63
326
K70.9
ICD-10 Finland
Alcoholic liver disease, unspecified
18.4
6.3
9
5
G93.99
ICD-10 Finland
Disorder of brain, unspecified
+∞
6.3
6
*
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
+∞
6.3
6
*
G91.0
ICD-10 Finland
Communicating hydrocephalus
+∞
6.3
6
*
T36
ICD-10 Finland
Poisoning by systemic antibiotics
3.6
6.2
20
57
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
6.5
6.2
15
24
N05AN01
ATC
lithium; oral
6.5
6.2
15
24
ZXD05
NOMESCO Finland
Urgent procedure
1.8
6.2
114
727
F10.9
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Unspecified mental and behavioural disorder
7.9
6.2
13
17
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.4
6.1
41
179
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
3.5
6.1
21
63
UJF92
NOMESCO Finland
Capsular endoscopy
5.7
6.1
16
29
WX882
NOMESCO Finland
High dependency care
4.0
6.1
17
44
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.9
6.0
28
101
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
130
71
27.31
171.44
11.5
2.6
52.34
33.55
umol/l
6.81
121
65
124
309
5.47
49.19
15.0
7.0
11.31
10.00
mmol/l
1.11
119
295
56
66
9.78
45.00
1.8
1.6
3.31
19.49
e6/l
0.87
45
51
56
68
9.49
43.96
1.9
1.6
307.12
1820.09
e6/l
0.43
49
53
147
460
4.58
43.47
11.1
5.9
1.08
1.05
mmol/l
0.64
141
427
120
331
4.84
41.48
5.5
2.3
0.15
0.21
g/l
11.42
113
307
38
28
14.97
41.37
1.7
1.1
—
—
—
0
0
151
567
3.76
33.28
5.9
3.0
0.77
0.82
mmol/l
3.92
143
539
33
33
10.86
29.56
1.3
1.1
—
—
—
0
0
107
344
3.94
29.17
6.0
4.2
1.58
1.56
mmol/l
0.02
91
291
58
143
4.61
22.23
3.2
1.4
0.25
0.35
mg/l
0.73
28
62
37
62
6.50
21.65
1.2
1.1
341.96
304.03
u/ml
0.19
23
31
193
1036
2.75
20.84
5.9
2.6
64.84
66.18
u/l
0.05
185
961
95
353
3.25
20.07
2.5
1.7
1.78
1.51
%
2.71
84
303
42
88
5.24
19.44
1.5
1.3
—
—
—
0
0
26
33
8.38
19.38
1.2
1.0
—
—
—
0
0
57
154
4.18
19.33
2.0
2.3
0.97
1.46
g/l
4.30
51
142
103
410
3.07
19.28
9.9
3.4
23.02
7.78
umol/l
1.74
94
367
102
405
3.08
19.17
4.1
5.0
238.67
271.87
u/l
1.17
93
387
27
13
22.25
18.89
4.2
1.5
1126.60
8664.50
e6/l
—
15
6
123
546
2.85
18.85
4.1
2.5
2.09
2.27
g/l
2.34
117
508
238
1466
2.67
18.82
16.3
5.4
31.73
35.59
g/l
16.52
227
1382
99
394
3.05
18.47
13.4
8.0
0.88
0.86
mmol/l
0.02
85
325
38
77
5.37
18.24
7.4
7.6
3792.14
259.64
iu/ml
—
7
11
128
590
2.76
18.16
3.0
1.9
—
—
—
0
0
26
36
7.68
18.02
1.2
1.0
—
—
—
0
0
25
11
24.21
17.99
4.2
2.9
66.16
106.55
%
3.92
25
11
27
16
18.06
17.66
1.4
1.1
—
—
—
0
0
115
509
2.81
17.56
4.3
2.5
25.62
23.05
%
0.71
109
479
33
62
5.73
17.16
1.2
1.4
102.71
141.43
au/ml
—
7
22
124
577
2.71
17.13
1.8
1.7
1248.13
1157.76
nmol/l
0.40
103
439
71
242
3.38
17.08
2.4
1.6
—
—
—
0
0
23
12
20.31
15.75
1.5
1.2
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
40
96
4.54
15.72
4.4
2.5
0.23
0.35
iu/ml
2.25
22
51
25
17
15.65
15.58
1.2
1.1
1.89
1.91
mmol/l
0.03
25
17
250
1672
2.45
15.16
17.3
7.4
1.20
1.21
mmol/l
1.67
228
1445
37
86
4.66
15.12
3.2
1.5
—
—
—
0
0
105
475
2.67
15.11
12.1
7.5
104.30
104.20
mmol/l
0.06
105
475
158
868
2.40
15.01
3.5
2.1
3.38
3.00
mg/l
0.79
149
749
238
1576
2.37
14.49
23.7
15.5
1.27
1.28
inr
0.12
221
1307
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
24
20
12.72
13.79
1.4
1.1
—
—
—
0
0
95
437
2.57
13.02
2.9
1.9
—
—
—
0
0
89
413
2.51
11.89
2.9
1.9
—
—
—
0
0
60
233
2.87
11.36
8.8
3.9
2.26
1.89
mmol/l
0.26
44
175
34
93
3.92
11.23
2.4
2.7
205.00
190.78
%
0.34
34
88
23
27
8.99
11.20
1.2
1.0
—
—
—
0
0
222
1527
2.09
11.03
17.1
6.7
1.20
1.21
mmol/l
2.09
213
1404
36
105
3.68
10.86
1.5
1.4
298.81
282.01
ug/g
0.18
21
58
260
1928
2.10
10.17
14.5
5.1
7.51
6.80
mmol/l
3.53
255
1843
19
19
10.46
10.13
1.5
1.2
0.78
0.50
ratio
—
14
9
19
20
9.94
9.88
1.4
1.0
—
—
—
0
0
36
112
3.45
9.86
1.5
1.3
—
—
—
0
0
205
1416
1.97
9.55
4.9
2.9
159.38
152.24
ug/l
0.18
196
1313
71
327
2.44
9.50
2.1
1.9
464.49
389.13
nmol/l
0.36
71
304
115
649
2.11
9.44
1.9
1.8
464.46
39630055.87
pmol/l
0.94
100
540
16
13
12.79
9.44
1.1
1.2
—
—
—
0
0
15
11
14.14
9.25
1.2
1.0
—
—
—
0
0
16
14
11.87
9.15
3.7
2.2
0.57
0.59
mmol/l
0.26
16
14
125
747
2.00
8.67
3.4
2.8
5.82
4.52
e6/l
0.61
116
684
53
222
2.61
8.62
16.5
10.3
94.26
93.60
%
0.35
53
222
131
804
1.96
8.37
4.9
2.5
—
—
—
0
0
148
951
1.91
8.22
2.1
1.7
18.51
19.83
nmol/l
0.53
133
793
14
12
12.06
8.14
2.1
1.1
—
—
—
0
0
164
1096
1.87
8.02
4.6
3.4
67.79
123.64
e6/l
0.39
135
849
53
230
2.52
8.01
4.8
4.0
108.29
94.26
ng/l
0.31
48
198
51
218
2.55
7.95
2.0
1.7
—
—
—
0
0
265
2072
1.92
7.77
7.3
4.5
89.88
2129.03
e6/l
—
8
32
196
1399
1.83
7.65
3.4
2.4
70.17
76.29
nmol/l
1.98
182
1249
43
172
2.69
7.65
1.6
1.4
—
—
—
0
0
26
78
3.50
7.53
2.0
1.3
—
—
—
0
0
34
122
2.96
7.38
2.6
1.6
—
—
—
0
0
44
183
2.59
7.24
1.3
1.3
30.00
47.77
au/ml
—
6
15
116
715
1.90
7.14
2.1
1.8
2.25
1.52
mg/l
0.81
96
569
106
637
1.92
7.04
4.7
3.8
270.47
415.86
ng/l
0.28
85
522
63
313
2.21
7.00
5.9
2.7
32.53
33.63
u/l
0.09
57
262
19
48
4.11
6.97
1.4
1.3
—
—
—
0
0
203
1492
1.77
6.95
5.3
2.9
—
—
estimate
—
0
0
37
144
2.74
6.93
1.9
2.3
42.68
39.82
u/l
0.26
30
128
17
40
4.40
6.82
1.4
2.0
—
—
—
0
0
236
1823
1.78
6.70
15.8
10.7
3.87
4.18
e9/l
1.37
222
1574
111
690
1.86
6.59
1.4
1.4
1.03
1.75
u/ml
0.83
23
172
18
34
5.50
6.55
1.3
1.1
—
—
—
0
0
11
10
11.28
6.33
1.5
1.1
—
—
—
0
0
11
10
11.28
6.33
1.4
1.1
—
—
—
0
0
9
5
18.38
6.29
1.0
1.2
—
—
—
0
0
13
17
7.87
6.17
1.5
1.0
—
—
—
0
0
11
11
10.26
6.07
1.4
1.1
—
—
—
0
0
33
130
2.68
6.05
3.0
1.8
—
—
—
0
0
29
108
2.82
5.91
3.9
4.3
3.19
2.97
ratio
0.06
20
56
32
127
2.66
5.79
3.3
2.8
—
—
—
0
0
194
1458
1.68
5.73
2.9
2.1
93.16
94.69
pmol/l
0.15
116
775
260
3006
0.57
5.67
5.5
5.2
1.28
1.42
mmol/l
7.59
243
2771
37
160
2.45
5.63
10.8
4.3
24.53
24.75
mmol/l
0.13
37
149
9
7
13.13
5.60
1.0
1.1
—
—
—
0
0
269
3076
0.57
5.49
6.4
6.0
2.41
2.67
mmol/l
5.74
253
2837
263
3024
0.58
5.45
5.7
5.3
4.18
4.56
mmol/l
8.64
246
2808
10
11
9.30
5.31
1.4
1.1
—
—
—
0
0
153
1097
1.66
5.31
3.0
3.2
1772.80
1454.71
ng/l
0.35
140
942
5
0
+∞
5.22
1.4
0.0
—
—
—
0
0
49
859
0.51
4.79
2.5
3.2
0.53
0.76
ug/l
3.75
33
579
19
64
3.07
4.62
1.9
1.3
—
—
—
0
0
19
64
3.07
4.62
1.9
1.3
—
—
—
0
0
7
5
14.22
4.59
1.1
1.2
—
—
—
0
0
158
1175
1.59
4.56
4.4
3.3
6.85
7.93
mmol/l
2.82
145
985
39
190
2.17
4.54
5.7
3.0
0.61
0.62
%
0.13
39
190
13
27
4.95
4.54
1.2
1.1
55.54
45.77
u/l
0.31
13
22
22
82
2.79
4.50
2.2
1.5
—
—
—
0
0
10
15
6.81
4.49
1.1
1.1
—
—
—
0
0
134
961
1.61
4.49
4.2
3.3
0.65
0.60
e6/l
0.09
106
713
13
28
4.77
4.41
1.0
1.0
—
—
—
0
0
9
12
7.65
4.38
2.1
2.0
—
—
—
0
0
11
21
5.36
4.17
1.5
1.4
—
—
—
0
0
47
254
1.97
4.17
4.4
2.8
63.88
63.77
ml/min/173m2
0.01
25
113
10
17
6.01
4.15
6.5
4.2
4.70
7.52
ug/l
—
10
17
90
594
1.68
4.15
3.5
3.0
2.27
0.96
e6/l
0.84
52
332
24
98
2.55
4.14
1.5
1.7
—
—
—
0
0
284
2456
1.62
4.01
23.4
8.8
102.58
81.59
u/l
7.19
276
2324
27
119
2.37
3.97
1.7
2.2
4.35
7.71
iu/ml
0.35
11
24
63
381
1.78
3.96
3.0
4.8
17.51
39.58
ug/l
0.45
55
319
28
126
2.32
3.94
1.9
3.0
0.82
1.21
g/l
0.25
22
111
19
71
2.76
3.88
1.1
1.2
61.32
27.60
u/l
0.64
19
59
23
96
2.49
3.80
2.1
1.7
—
—
—
0
0
22
90
2.53
3.79
2.1
1.6
—
—
—
0
0
9
16
5.73
3.68
1.2
1.6
—
—
—
0
0
165
1291
1.49
3.55
6.5
3.9
330.26
45.25
ng/l
0.46
143
970
11
26
4.32
3.53
1.1
1.3
—
—
—
0
0
11
26
4.32
3.53
3.5
2.7
—
—
—
0
0
8
13
6.26
3.52
1.5
1.0
1026.50
1130.23
miu/ml
—
8
13
147
1125
1.50
3.51
5.2
3.6
2.32
2.35
mmol/l
1.72
131
1023
22
94
2.42
3.48
1.4
1.4
—
—
—
0
0
245
2083
1.50
3.43
11.8
3.5
97.50
53.28
u/l
5.07
236
1959
119
875
1.52
3.42
5.2
3.1
398.26
354.65
umol/l
2.93
108
758
81
547
1.61
3.37
4.0
3.1
4.06
1.82
e6/l
0.64
43
285
24
110
2.26
3.26
1.5
1.2
0.90
4.42
u/ml
—
6
6
100
1341
0.65
3.26
2.4
2.0
1.54
1.37
mmol/l
0.78
86
1112
15
56
2.75
3.09
5.3
3.4
9.85
8.97
pmol/l
0.10
15
56
259
2887
0.68
3.02
4.7
4.4
1.38
1.31
mmol/l
0.74
239
2640
15
57
2.70
3.00
1.7
1.5
—
—
—
0
0
20
88
2.34
2.99
1.7
1.5
—
—
—
0
0
5
5
10.11
2.98
1.2
1.2
—
—
—
0
0
8
17
4.78
2.93
1.4
1.1
—
—
—
0
0
7
13
5.46
2.88
1.6
3.2
403.86
1133.85
u/ml
—
7
13
18
77
2.40
2.86
1.3
1.3
—
—
—
0
0
17
71
2.46
2.84
1.9
1.5
—
—
—
0
0
11
33
3.40
2.83
1.2
1.5
—
—
—
0
0
5
6
8.42
2.75
1.6
1.0
—
—
—
0
0
5
6
8.42
2.75
1.6
1.0
—
—
—
0
0
101
749
1.47
2.72
6.4
4.0
1.02
1.02
kg/l
0.18
74
494
145
1157
1.41
2.62
5.4
4.0
15.27
9.17
mg/mmol
0.70
117
746
17
74
2.36
2.62
2.1
1.4
—
—
—
0
0
8
20
4.06
2.58
2.8
2.2
—
—
—
0
0
11
37
3.03
2.51
1.4
2.1
—
—
—
0
0
15
63
2.44
2.49
2.1
1.9
—
—
—
0
0
8
21
3.87
2.47
3.9
3.1
1.50
0.86
index
—
8
21
52
346
1.58
2.30
5.4
3.4
—
—
—
0
0
12
47
2.60
2.29
1.6
2.3
34.08
33.19
pg
0.20
12
47
89
1157
0.70
2.29
3.5
4.7
18.60
21.96
%
1.33
37
579
12
49
2.50
2.12
2.2
1.6
—
—
—
0
0
8
25
3.25
2.10
4.1
2.0
227.25
149.63
e6/l
—
8
19
8
25
3.25
2.10
3.8
1.9
569.75
489.47
e6/l
—
8
17
6
15
4.05
2.04
1.5
1.7
70.15
108.08
ug/l
—
6
15
20
105
1.96
1.99
1.8
1.4
0.00
0.05
iu/ml
—
5
23
7
21
3.38
1.97
1.9
1.7
—
—
—
0
0
7
21
3.38
1.97
1.9
1.7
—
—
—
0
0
258
2322
1.35
1.96
8.0
4.4
20.01
12.71
mm/h
6.50
246
2157
272
2938
0.74
1.86
9.8
6.7
41.96
39.74
mmol/mol
2.16
261
2760
10
40
2.54
1.68
1.7
1.6
—
—
—
0
0
10
40
2.54
1.68
1.7
1.6
—
—
—
0
0
7
25
2.83
1.65
1.6
1.2
—
—
—
0
0
7
25
2.83
1.65
1.6
1.2
—
—
—
0
0
10
41
2.48
1.65
1.7
1.6
—
—
—
0
0
10
41
2.48
1.65
1.9
1.6
—
—
—
0
0
122
1451
0.77
1.64
3.4
5.5
1.46
3.09
ug/l
2.44
109
1299
10
42
2.42
1.63
2.0
1.6
—
—
—
0
0
10
42
2.42
1.63
2.0
1.6
—
—
—
0
0
191
1677
1.28
1.60
5.6
3.9
0.00
5.61
estimate
0.50
35
335
188
1650
1.28
1.57
5.6
3.9
0.00
0.00
estimate
-0.00
34
330
318
3335
0.72
1.56
65.1
25.7
124.25
135.84
g/l
21.70
313
3304
318
3333
0.72
1.52
64.2
25.6
4.11
4.50
e12/l
20.02
312
3256
318
3333
0.72
1.52
66.1
26.1
36.94
40.45
%
15.64
313
3302
9
37
2.47
1.49
7.2
1.8
11.64
10.38
mmol/l
—
9
37
10
46
2.21
1.41
1.0
1.0
—
—
—
0
0
10
46
2.21
1.41
2.2
1.6
—
—
—
0
0
252
2311
1.27
1.39
4.8
3.9
14.64
14.86
pmol/l
0.72
235
2097
112
937
1.28
1.34
6.2
4.0
0.00
0.02
estimate
0.78
28
300
189
1681
1.25
1.34
5.5
3.9
0.00
1.00
estimate
0.51
32
304
280
2974
0.78
1.33
6.4
5.3
6.53
6.03
mmol/l
5.24
262
2721
9
43
2.12
1.31
2.7
1.7
—
—
—
0
0
84
683
1.30
1.26
3.5
3.1
2.50
2.45
mmol/l
1.86
70
615
277
2940
0.79
1.25
40.6
16.4
75.37
78.76
ml/min/173m2
1.32
263
2721
15
85
1.80
1.25
5.6
2.3
127.13
129.40
g/l
0.09
15
68
9
45
2.02
1.24
4.6
2.9
105.78
105.27
mmol/l
—
9
45
7
31
2.28
1.11
3.1
2.3
36.00
39.64
mg/l
—
7
25
7
33
2.14
1.06
1.3
1.5
—
—
—
0
0
7
34
2.08
1.03
2.7
1.6
—
—
—
0
0
6
28
2.16
0.92
1.3
1.1
77.00
101.96
pmol/l
—
6
28
142
1268
1.19
0.89
6.1
3.9
0.13
0.03
estimate
0.34
30
283
8
43
1.88
0.88
5.0
3.0
1.21
1.19
mmol/l
—
8
43
6
32
1.89
0.82
1.3
1.2
—
—
—
0
0
6
32
1.89
0.82
1.8
1.7
—
—
—
0
0
6
32
1.89
0.82
1.3
1.1
—
—
—
0
0
6
32
1.89
0.82
1.8
1.7
—
—
—
0
0
6
32
1.89
0.82
1.8
1.7
—
—
—
0
0
313
3234
0.82
0.75
28.4
12.6
29.55
26.66
u/l
1.66
306
3147
5
24
2.10
0.75
1.2
1.8
—
—
—
0
0
5
25
2.01
0.73
1.4
1.5
—
—
—
0
0
10
61
1.66
0.69
1.4
1.3
—
—
—
0
0
14
94
1.51
0.67
2.1
1.1
0.87
0.93
g/l
0.26
14
94
6
103
0.58
0.63
1.2
1.8
3.19
2.79
mg/l
—
6
71
0
21
0.00
0.60
0.0
1.7
—
—
—
0
0
6
36
1.68
0.57
3.5
5.3
—
—
—
0
0
21
159
1.34
0.56
1.2
1.2
52.09
128.40
u/ml
2.31
11
60
185
1740
1.12
0.52
3.6
2.8
—
—
—
0
0
11
78
1.42
0.43
1.0
1.1
—
3.54
—
0
8
31
258
1.22
0.43
1.8
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
50.92
—
0
15
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
1.6
—
—
—
0
0
43
375
1.17
0.38
11.0
7.1
—
—
—
0
0
13
98
1.34
0.38
1.4
1.3
—
—
—
0
0
5
37
1.36
0.37
1.0
1.1
—
—
—
0
0
313
3071
1.11
0.30
47.1
16.7
22.31
25.81
mg/l
1.87
292
2551
31
352
0.87
0.27
2.8
2.4
15.38
13.39
nmol/l
0.48
26
321
12
95
1.27
0.26
1.8
1.6
—
—
—
0
0
9
73
1.24
0.25
1.3
1.7
—
—
—
0
0
9
73
1.24
0.25
1.2
2.0
—
—
—
0
0
11
87
1.27
0.24
1.1
1.2
—
—
—
0
0
5
39
1.29
0.23
1.4
1.3
0.78
0.57
nmol/l
—
5
33
11
88
1.26
0.23
1.1
1.2
—
—
—
0
0
7
91
0.76
0.22
2.0
2.1
163.00
226.57
pmol/l
—
7
83
95
900
1.07
0.22
4.8
3.4
0.00
0.10
estimate
0.55
29
259
0
11
0.00
0.21
0.0
1.0
—
0.17
—
0
11
0
11
0.00
0.21
0.0
1.2
—
287.33
—
0
6
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
28.14
—
0
6
31
344
0.89
0.20
1.6
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
40.49
—
0
14
12
140
0.85
0.15
1.1
1.3
—
—
—
0
0
45
422
1.08
0.14
5.2
4.9
29.03
31.33
%
0.87
37
276
19
211
0.90
0.13
1.6
1.9
—
—
—
0
0
52
493
1.06
0.12
1.3
1.3
28.41
12.85
u/ml
0.34
20
178
56
536
1.05
0.10
1.3
1.3
64.85
35.77
iu/ml
0.48
15
165
8
74
1.08
0.07
1.1
1.3
—
291.22
miu/ml
—
0
28
17
157
1.09
0.07
1.1
1.0
—
—
—
0
0
10
89
1.13
0.07
1.2
2.0
—
—
—
0
0
18
191
0.94
0.04
1.7
1.9
—
—
—
0
0
282
2814
1.01
0.00
5.8
4.9
1.96
1.97
mu/l
0.04
262
2559
46
455
1.01
0.00
1.3
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
11.6
—
10.62
—
0
5
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
5
53
0.94
-0.00
1.2
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_ENCEPATH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ENCEPATH | 5.197 [4.2, 6.43] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.725 |
During the follow-up period (1.1.1998 — 31.12.2019), 510 out of 1064 females with G6_ENCEPATH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ENCEPATH | 4.951 [4.13, 5.93] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 805 out of 1493 males with G6_ENCEPATH died.
Mortality risk
Mortality risk for people of age
years, who have G6_ENCEPATH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.537% | 0.72% |
| 5 | 3.665% | 5.005% |
| 10 | 8.454% | 11.984% |
| 15 | 15.556% | 22.374% |
| 20 | 26.651% | 35.56% |
Relationships between endpoints
↥Index endpoint: G6_ENCEPATH – Encephalopathy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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