Other cranial nerve disorders in other disorders

G6_CRAINOTH

cranial nerve palsy: Injury to any of the cranial nerves or their nuclei in the brain resulting in muscle weakness.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G53, G53.0B02.20, G53.0B02.21 Hospital discharge:* excluded ICD-10 — G53.0, G53.0B02.20, G53.0B02.21 Cause of death:* ICD-10 — G53, G53.0B02.20, G53.0B02.21 Cause of death:* excluded ICD-10 — G53.0, G53.0B02.20, G53.0*B02.21 2 out of 7 registries used, show all original rules.	109
4. Check minimum number of events None	109
5. Include endpoints None	109
6. Filter based on genotype QC (FinnGen only)	93

Control definitions (FinnGen only)

Control exclude: G6_NERPLEX

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2

NAME	G6_CRAINOTH
CONTROL_EXCLUDE	G6_NERPLEX
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G53
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL	G530
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G53
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL	G530
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other cranial nerve disorders in other disorders based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	548	312	234
Only index persons	506	292	214
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	50.47	51.53	48.97
Only index persons	48.97	49.40	48.38

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	93	55	38
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	47.71	46.13	50.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
97: Matched controls
970

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

G53.2*D86.8

ICD-10 Finland

Multiple cranial nerve palsies in sarcoidosis

+∞

76.5

D86.8

ICD-10 Finland

Sarcoidosis of other and combined sites

184.8

57.9

D86.9

ICD-10 Finland

Sarcoidosis, unspecified

128.0

38.3

132

Kela drug reimbursment

Sarcoidosis

171.6

34.2

D86.0

ICD-10 Finland

Sarcoidosis of lung

98.3

31.3

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

13.0

31.0

TAB00

NOMESCO Finland

Lumbar puncture

14.4

30.0

G51.0

ICD-10 Finland

Bell palsy

+∞

26.2

G53.2

ICD-10 Finland

Multiple cranial nerve palsies in sarcoidosis

+∞

19.4

D86.2

ICD-10 Finland

Sarcoidosis of lung with sarcoidosis of lymph nodes

62.1

17.8

M05BA04

ATC

alendronic acid; oral

8.8

16.5

H02AB06

ATC

prednisolone; systemic

6.6

16.2

318

Z01.0

ICD-10 Finland

Examination of eyes and vision

5.3

13.9

109

L04AX01

ATC

azathioprine; systemic

14.6

13.1

H04.10

ICD-10 Finland

Dry eye syndrome

5.6

12.3

D86.1

ICD-10 Finland

Sarcoidosis of lymph nodes

74.2

11.9

AA1DG

NOMESCO Finland

Very extensive MRI examination of brain with high intensity magnet

14.4

11.4

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

4.8

9.5

G53.1

ICD-10 Finland

Multiple cranial nerve palsies in infectious and parasitic diseases classified elsewhere

+∞

9.5

GD1AA

NOMESCO Finland

Thorax X-ray examination

3.9

9.2

335

Z03.3

ICD-10 Finland

Observation for suspected nervous system disorder

9.2

N03AX12

ATC

[U] gabapentin; oral

4.3

8.9

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

3.6

8.8

230

D86.3

ICD-10 Finland

Sarcoidosis of skin

98.2

8.6

AA1CM

NOMESCO Finland

Extensive MRI examination of brain with 3 Tesla magnet

36.7

8.2

H02AB07

ATC

prednisone; oral

4.3

7.9

M14.8*D86.8

ICD-10 Finland

Arthropathy in sarcoidosis

+∞

7.4

R42

ICD-10 Finland

Dizziness and giddiness

3.4

7.4

143

XCK00

NOMESCO Finland

Perimetry

7.4

7.3

TPH04

NOMESCO Finland

Cathetrisation of vein

3.4

7.1

127

A02BC01

ATC

omeprazole; systemic

3.3

7.0

154

L04AX03

ATC

methotrexate; systemic

4.2

6.7

R20.2

ICD-10 Finland

Paraesthesia of skin

4.7

6.7

NK6QA

NOMESCO Finland

Measurement of bone density from two or more locations with X-ray

6.2

6.5

G56.0

ICD-10 Finland

Carpal tunnel syndrome

9.6

6.3

GD1DD

NOMESCO Finland

High resolution CT examination of lungs

6.6

6.1

UJF32

NOMESCO Finland

Coloscopy

3.1

6.1

151

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3044290) Cell count panel - Cerebral spinal fluid

14.42

10.88

1.6

1.3

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

21.14

9.22

1.2

1.0

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

22.51

8.71

1.0

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

3.72

6.86

3.5

1.7

323.38

387.14

nmol/l

0.84

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

13.58

6.77

1.0

1.1

—

(3001604) Monocytes [#/volume] in Blood

442

3.26

6.44

12.2

7.2

0.56

e9/l

0.11

381

(3006315) Basophils [#/volume] in Blood

443

3.25

6.39

12.1

7.2

0.04

e9/l

0.57

379

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

397

3.07

6.31

11.1

7.4

1.22

1.21

mmol/l

0.70

345

(42870588) Differential panel, method unspecified - Blood

275

2.92

6.31

12.5

6.2

—

(3013115) Eosinophils [#/volume] in Blood

456

3.25

6.25

12.2

7.5

0.21

0.19

e9/l

0.55

399

(3019198) Lymphocytes [#/volume] in Blood

447

3.20

6.21

12.1

7.2

1.71

2.10

e9/l

0.98

396

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

10.98

5.68

1.0

1.1

—

(3016018) Differential panel - Cerebral spinal fluid

14.36

5.17

1.6

1.2

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

490

2.68

4.49

15.2

11.5

4.02

4.03

e9/l

0.00

430

(3004789) Transferrin [Mass/volume] in Serum or Plasma

125

2.74

4.44

2.8

2.3

2.36

g/l

0.01

114

(3023410) Appearance of Cerebral spinal fluid

9.55

4.37

2.0

1.3

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

12.43

4.34

1.1

1.0

—

(36304997) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] in Blood

5.11

4.22

2.1

1.3

—

0.11

—

(3035715) Granulocytes [#/volume] in Blood

8.59

4.14

2.9

2.4

3.93

5.80

e9/l

—

(3026008) Bacteria identified in Urine by Culture

235

2.39

4.13

5.9

3.0

—

(3023368) Bacteria identified in Blood by Culture

224

2.34

3.88

4.1

4.0

—

(3011391) Calcitriol [Moles/volume] in Serum or Plasma

9.31

3.84

3.1

1.5

115.71

100.00

pmol/l

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

4.01

3.66

2.1

2.2

0.71

1.04

mmol/l

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.58

3.38

1.7

1.4

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

305

2.14

3.31

4.9

3.7

14.42

30.66

ng/l

2.48

210

(3018418) pH of Serum or Plasma

245

2.17

3.31

9.1

4.3

7.41

7.40

0.87

171

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

118

2.37

3.05

2.8

2.3

23.11

23.08

0.00

110

(3035933) Granulocytes/Leukocytes in Blood

5.03

2.99

3.0

2.7

56.88

63.85

—

(3028626) Oxygen [Partial pressure] in Capillary blood

5.30

2.78

1.9

1.1

8.49

8.51

kpa

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

286

1.99

2.73

5.8

3.1

—

(3045414) Leukocytes [Presence] in Urine

2.50

2.62

3.4

2.1

0.00

estimate

—

(40760888) Immunoglobulin light chains.free panel - Serum

5.25

2.44

4.3

6.2

—

(3015235) Bicarbonate [Moles/volume] in Capillary blood

3.86

2.42

2.8

1.9

23.49

25.17

mmol/l

—

(3036603) Volume of Urine

6.51

2.40

1.4

2.6

2088.00

1465.63

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

5.78

2.24

2.0

1.2

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

104

2.16

2.20

2.1

1.7

—

(3022313) Gas panel - Capillary blood

2.99

2.06

1.9

2.6

—

(3021589) Normoblasts [#/volume] in Blood

391

1.78

2.06

16.5

11.8

0.01

0.00

e9/l

0.48

312

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

101

2.10

1.98

2.2

1.7

—

(3021901) Oxygen saturation in Capillary blood

4.73

1.96

1.8

1.2

87.60

90.95

—

(3032080) INR in Blood by Coagulation assay

377

1.74

1.93

19.1

13.3

1.18

1.26

inr

0.51

301

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

4.33

1.84

2.0

1.2

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

4.33

1.84

2.2

1.0

388.80

243.67

pmol/l

—

(3021601) Nitrite [Presence] in Urine by Test strip

479

1.74

1.82

5.2

3.6

0.00

estimate

-0.00

(3030467) Casts [#/volume] in Urine by Automated count

228

1.76

1.78

4.9

2.8

0.10

0.43

e6/l

2.51

154

(3037522) Nuclear Ab [Titer] in Serum

113

1.97

1.77

1.7

1.4

424.00

447.41

titre

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

3.99

1.73

1.6

1.8

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

3.99

1.73

1.6

1.8

—

(3035350) Ketones [Presence] in Urine by Test strip

483

1.71

1.73

5.4

3.6

73.67

0.00

estimate

0.48

(3020682) Albumin/Creatinine [Ratio] in Urine

294

1.68

1.67

5.2

3.7

4.36

8.80

mg/mmol

0.67

189

(4024509) Urine culture

2.63

1.64

1.1

1.9

—

(3009261) Glucose [Presence] in Urine by Test strip

488

1.67

1.62

5.3

3.6

0.19

0.00

estimate

0.48

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

2.82

1.61

1.3

1.7

—

(3009508) Creatinine [Moles/volume] in Urine

306

1.66

1.60

4.2

2.9

7.71

8.11

mmol/l

0.21

273

(3002582) Erythrocytes [#/volume] in Urine

261

1.68

1.59

6.4

3.1

10.22

43.05

e6/l

1.42

190

(40760892) CBC W Ordered Manual Differential panel - Blood

226

1.70

1.58

7.7

6.4

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

262

1.67

1.57

4.8

2.9

833.60

1326.56

ng/l

0.69

222

(3022145) Colonoscopy Study observation

1.96

1.55

1.6

1.5

—

(1616796) Gas panel - Central venous blood

3.45

1.54

1.6

1.9

—

(3027945) Reticulocytes/Erythrocytes in Blood

1.98

1.52

3.2

3.4

1.82

1.80

0.05

(3012516) Albumin [Mass/volume] in Urine

282

1.64

1.52

4.5

3.1

43.55

52.31

mg/l

0.14

191

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

160

1.76

1.51

1.1

1.2

1.37

4.09

u/ml

0.75

(3019977) pH of Arterial blood

1.96

1.48

8.2

9.2

7.47

7.41

—

(40758558) Short blood count panel - Blood

266

1.63

1.46

9.1

6.0

—

(3048689) Calprotectin [Mass/mass] in Stool

105

1.88

1.45

2.6

60.31

158.85

ug/g

1.22

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

146

1.75

1.43

1.8

1.7

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

3.04

1.37

1.0

1.6

—

(3002256) Pathology report gross observation

100

1.85

1.34

1.4

1.3

—

(40768443) Skin Pathology biopsy report

2.40

1.30

1.1

1.2

—

(40768804) Tissue Pathology biopsy report

347

1.55

1.30

2.4

2.1

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

2.87

1.30

1.0

1.1

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

405

1.55

1.29

4.8

2.9

136.75

117.42

ug/l

0.26

381

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

134

1.72

1.28

2.1

1.8

—

(3012544) pH of Venous blood

1.84

1.27

2.9

4.1

7.39

7.38

—

(3029937) Albumin [Presence] in Urine by Test strip

275

1.56

1.25

4.8

3.6

0.00

estimate

-0.00

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

371

1.52

1.20

2.6

2.5

—

estimate

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.09

1.15

1.9

2.2

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

155

1.63

1.15

6.7

3.3

21.06

385.91

ng/l

1.19

115

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

367

1.48

1.09

2.2

2.0

94.83

94.60

pmol/l

0.01

185

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

175

1.58

1.07

1.2

1.3

11.50

33.44

iu/ml

—

(4035726) Immunohistochemistry procedure

1.87

1.06

1.2

1.3

—

(3000494) Fungus identified in Specimen by Culture

100

1.72

1.05

1.3

1.6

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

2.02

0.99

1.0

1.1

—

(3042936) Bacteria identified in Isolate by Culture

110

1.66

0.99

2.6

1.9

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

382

1.45

0.99

2.0

1.9

1.40

1.43

mmol/l

0.07

323

(3004588) Protein electrophoresis panel - Serum or Plasma

1.91

0.96

6.7

1.5

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.84

0.94

1.1

1.7

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.88

0.91

1.7

2.6

1.50

1.28

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.88

0.91

1.7

2.6

0.64

0.67

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

1.98

0.91

3.0

1.4

15.57

30.13

iu/l

—

(40761536) Microorganisms panel - Urine sediment

1.81

0.90

6.4

3.2

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

141

1.53

0.83

4.5

2.5

1.79

1.19

e6/l

0.26

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

124

1.55

0.82

7.9

2.7

1.63

3.22

e6/l

0.67

(3041096) Erythrocytes [Presence] in Urine by Automated

268

1.41

0.82

5.1

3.1

0.00

estimate

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

143

1.50

0.78

1.6

2.1

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.14

0.75

3.2

2.3

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

208

1.41

0.73

2.0

1.6

7.33

1.36

mg/l

0.40

173

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.76

0.71

1.1

1.2

—

(3025941) Bacteria identified in Stool by Culture

1.76

0.71

1.4

1.2

—

(3044640) Blood type and Crossmatch panel - Blood

246

1.38

0.71

2.3

2.2

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

191

1.42

0.70

2.1

—

(3018095) Leukocytes [#/volume] in Urine

313

1.35

0.69

8.9

3.6

20.48

95.28

e6/l

1.46

202

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

371

1.34

0.68

5.0

3.6

0.00

estimate

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

1.83

0.67

4.0

1.4

92.40

96.71

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.64

0.66

2.6

2.2

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

103

0.56

0.66

1.5

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

1.76

0.64

1.0

1.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

537

1.31

0.58

3.8

3.1

—

(3000991) Gas panel - Venous blood

1.53

0.53

5.2

10.0

—

(3020961) Endomysium IgA Ab [Titer] in Serum

1.53

0.52

1.2

1.1

—

(40768797) Stomach Pathology biopsy report

112

1.40

0.48

1.1

1.3

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

786

1.39

0.47

7.7

5.1

1.80

1.94

mu/l

0.52

719

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

842

1.49

0.47

25.5

14.6

16.30

22.97

mg/l

1.62

682

(3019060) Gas panel - Arterial blood

1.46

0.47

10.3

4.7

—

(3015736) pH of Urine

396

1.25

0.47

4.4

3.3

6.14

6.17

0.06

228

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.43

0.46

4.7

10.4

24.61

24.39

mmol/l

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

1.65

0.43

4.4

2.0

2.86

3.78

g/l

—

(3016879) Cocaine [Presence] in Urine

1.59

0.43

1.0

1.5

—

(3045716) Anion gap in Serum or Plasma by calculation

0.00

0.41

0.0

1.7

—

9.49

—

(3027944) Amphetamines [Presence] in Urine

1.50

0.41

1.0

1.5

—

(3000764) Benzodiazepines [Presence] in Urine

1.50

0.41

1.0

1.5

—

(3028300) Cannabinoids [Presence] in Urine

1.50

0.41

1.0

1.5

—

(3027008) Opiates [Presence] in Urine

1.50

0.41

1.0

1.5

—

(21494755) Public health laboratory ask at order entry panel

112

0.69

0.40

1.3

1.4

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

118

1.32

0.36

5.6

7.5

104.80

104.20

mmol/l

0.19

118

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

175

0.77

0.34

2.1

2.8

0.83

0.71

ug/l

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

228

0.79

0.34

2.4

4.1

22.19

22.57

—

101

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

807

1.31

0.32

9.1

6.1

41.12

39.19

mmol/mol

1.17

765

(3014007) Fractional oxyhemoglobin in Arterial blood

1.29

0.30

5.4

12.2

93.36

93.87

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

123

1.26

0.27

1.2

1.6

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.29

0.26

1.7

1.8

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.28

0.24

1.7

2.3

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.26

0.23

3.2

2.1

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.20

0.22

2.8

1.4

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.21

0.0

1.1

—

(40768441) Liver Pathology biopsy report

0.00

0.21

0.0

1.2

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

2.2

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.21

0.0

1.2

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

213.28

—

(3009595) Pneumocystis jirovecii DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.21

0.0

1.6

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.7

—

2.04

—

(3003694) ABO and Rh group [Type] in Blood

217

0.85

0.21

1.2

1.4

—

(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.2

—

2.20

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.21

0.20

1.3

1.4

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.16

0.17

1.5

1.9

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.14

0.15

3.3

3.2

—

(1761868) Lipid panel - Serum or Plasma

395

0.90

0.15

4.1

3.2

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.12

0.15

1.6

2.1

—

(3000492) Spirometry study

1.18

0.12

2.4

1.4

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

204

1.10

0.09

1.5

1.3

0.40

2.71

u/ml

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.07

0.09

1.2

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.15

0.09

8.5

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

147

1.11

0.08

2.0

1.5

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

813

0.98

0.00

5.0

4.3

1.51

1.32

mmol/l

1.08

760

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

165

0.96

0.00

2.2

2.3

2.41

2.44

mmol/l

0.75

150

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

826

1.03

0.00

5.3

5.0

5.98

5.91

mmol/l

0.17

763

(3009306) Alpha-1-Fetoprotein [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

3.0

—

4.58

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

-0.00

0.0

1.3

—

(3040370) OLANZapine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

3.6

—

165.60

—

(40761511) CBC panel - Blood by Automated count

874

1.07

-0.00

21.6

12.6

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

-0.00

0.0

3.2

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

-0.00

0.0

2.0

—

6.64

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.2

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.0

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

-0.00

0.0

1.7

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.2

—

66.83

—

(3038769) Chlamydophila pneumoniae IgG Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

12.76

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

60.24

—

(3020650) Glucose [Presence] in Urine

0.00

-0.00

0.0

1.2

—

0.00

—

(3026470) Cobalt [Mass/volume] in Blood

0.00

-0.00

0.0

2.8

—

3.38

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

-0.00

0.0

1.2

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

-0.00

0.0

1.8

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

-0.00

0.0

1.0

—

(3017704) Immunofixation for Urine

0.00

-0.00

0.0

1.2

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.4

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

0.96

-0.00

1.7

1.3

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.4

—

(3005570) Glucose [Moles/volume] in Urine

0.00

-0.00

0.0

1.3

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

-0.00

0.0

1.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

-0.00

0.0

4.0

—

1.00

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

-0.00

0.0

1.0

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(40768795) Lymph node Pathology biopsy report

0.00

-0.00

0.0

1.1

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(3015183) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells

0.00

-0.00

0.0

2.1

—

14.29

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

-0.00

0.0

1.2

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3013727) Leukocytes other/Leukocytes in Blood

0.00

-0.00

0.0

5.0

—

38.00

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

-0.00

0.0

1.0

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

-0.00

0.0

1.2

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.96

-0.00

1.5

1.4

—

Mortality – FinRegistry

↥

Association

Association between endpoint G6_CRAINOTH and mortality.

Females

Parameter	HR [95% CI]	p-value
G6_CRAINOTH	2.04 [1.48, 2.81]	< 0.001
Birth year	0.993 [0.98, 1.0]	0.114

During the follow-up period (1.1.1998 — 31.12.2019), 57 out of 292 females with G6_CRAINOTH died.

Males

Parameter	HR [95% CI]	p-value
G6_CRAINOTH	1.899 [1.36, 2.64]	< 0.001
Birth year	0.989 [0.98, 1.0]	0.037

During the follow-up period (1.1.1998 — 31.12.2019), 54 out of 223 males with G6_CRAINOTH died.

Mortality risk

Mortality risk for people of age

years, who have G6_CRAINOTH.

N-year risk	Females	Males
1	0.163%	0.463%
5	1.165%	2.375%
10	2.897%	6.245%
15	5.219%	11.758%
20	9.075%	18.899%

Relationships between endpoints

↥

Index endpoint: G6_CRAINOTH – Other cranial nerve disorders in other disorders

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other cranial nerve disorders in other disorders

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints