Hyperthyroidism: Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
350 |
4. Check minimum number of eventsNone |
350 |
5. Include endpointsNone |
350 |
6. Filter based on genotype QC (FinnGen only) |
323 |
Control definitions (FinnGen only)
- Control exclude
- THYROTOXICOSIS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E05
- Name in latin
- Thyreotoxicosis cum struma uninodulari
Similar endpoints
↥List of similar endpoints to
Thyrotoxicosis with toxic single thyroid nodule
based on the number of shared cases.
Similar with more cases:
- Thyrotoxicosis
- Disorders of thyroid, IBD co-morbidities
- Benign thyroid growths and nodules
- Endocrine, nutritional and metabolic diseases
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2093 | 1687 | 393 |
| Only index persons | 1884 | 1532 | 352 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.01 |
| Only index persons | 0.05 | 0.06 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 55.27 | 53.98 | 60.60 |
| Only index persons | 53.93 | 52.58 | 59.83 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 323 | 262 | 61 |
| Unadjusted period prevalence (%) | 0.08 | 0.09 | 0.03 |
| Median age at first event (years) | 52.61 | 49.63 | 65.38 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 331
- Matched controls
- 3310
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E05.1
ICD-10 Finland
Thyrotoxicosis with toxic single thyroid nodule
+∞
307.7
309
*
H03BB01
ATC
carbimazole; oral
904.2
280.4
238
9
BAA60
NOMESCO Finland
Total thyroidectomy
57.5
163.0
95
23
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
2406.8
157.6
140
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
1165.8
153.2
138
*
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
54.3
134.9
79
19
H03AA01
ATC
levothyroxine sodium; systemic
14.2
123.1
250
591
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
26.9
101.9
74
35
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
945.6
78.7
74
*
104
Kela drug reimbursment
Thyroid insufficiency
10.2
74.8
101
137
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
25.1
55.2
40
18
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
15.9
41.4
37
26
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
226.6
39.8
40
*
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
17.1
39.7
34
22
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
8.4
32.2
45
61
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
28.5
27
*
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
306.0
28.2
28
*
T86
ICPC
Hypothyroidism/myxoedema
6.5
27.2
48
84
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
3.9
26.5
104
352
C07AA05
ATC
propranolol; systemic
3.6
26.5
127
491
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
56.2
22.4
26
5
E03.89
ICD-10 Finland
Other specified hypothyroidism
6.6
22.2
38
64
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
+∞
22.1
21
*
2421A
ICD-9 Finland
Thyrotoxicosis with or without goitre, Toxic uninodular goitre
+∞
22.1
21
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
5.3
21.8
48
103
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.6
16.0
163
904
E05.89
ICD-10 Finland
Other thyrotoxicosis
+∞
14.7
14
*
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
134.9
12.5
13
*
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
9.9
12.2
24
26
H062, E050,
ICD-10 Finland
+∞
11.5
11
*
2504
FHL
Unilateral resection or enucleation
27.0
9.9
13
5
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
51.4
8.7
10
*
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
8.6
8.7
18
22
106
Kela drug reimbursment
Hypoparathyroidism
46.1
7.7
9
*
BA1AN
NOMESCO Finland
Thyroid gland isotope imaging
+∞
7.3
7
*
D44.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thyroid gland
7.6
7.3
16
22
A11CC03
ATC
alfacalcidol; systemic
6.9
6.9
16
24
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
23.1
6.7
9
*
E03
ICD-10 Finland
Other hypothyroidism
2.7
6.5
37
149
H06.2
ICD-10 Finland
Dysthyroid exophthalmos
+∞
6.3
6
*
E89.0
ICD-10 Finland
Postprocedural hypothyroidism
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
114
51
33.57
163.37
2.5
1.3
4.60
2.42
iu/l
1.09
55
15
155
169
16.37
140.69
5.8
2.4
4.89
4.33
pmol/l
5.74
143
145
74
219
4.06
22.52
4.2
3.2
63.51
78.01
ng/l
0.78
65
192
39
79
5.46
18.81
1.2
1.2
—
—
—
0
0
312
2411
6.12
16.69
13.4
4.5
15.45
14.67
pmol/l
6.96
301
2225
225
1488
2.60
14.70
10.1
6.1
1.22
1.22
mmol/l
0.51
200
1268
60
237
2.87
11.12
1.2
1.2
146.00
149.87
u/ml
0.02
28
96
194
1349
2.06
9.27
7.9
5.4
1.22
1.22
mmol/l
0.28
182
1232
117
709
2.01
7.92
2.1
2.0
—
—
—
0
0
193
1409
1.89
7.28
2.9
2.5
77.77
78.12
nmol/l
0.06
176
1269
314
2778
3.54
6.75
15.1
5.6
1.68
1.89
mu/l
1.74
304
2591
21
59
3.73
6.70
1.8
2.8
7.14
8.30
pmol/l
0.22
21
59
15
31
5.02
5.18
6.7
5.4
20.52
66.85
u/ml
—
5
13
58
315
2.02
5.14
1.9
2.0
389.94
386.03
nmol/l
0.05
52
297
266
2278
1.85
4.77
9.3
7.6
79.59
77.64
u/l
0.30
252
2154
123
874
1.65
4.42
2.8
3.2
1181.04
1133.80
ng/l
0.07
103
749
178
1390
1.61
4.33
2.7
2.6
—
—
estimate
—
0
0
24
97
2.59
4.24
2.2
1.8
—
—
—
0
0
211
1725
1.62
4.17
9.1
9.5
3.77
4.04
e9/l
1.30
191
1504
192
1540
1.59
4.07
3.4
3.1
87.12
97.22
ug/l
0.57
179
1439
23
93
2.58
4.06
2.0
1.7
—
—
—
0
0
74
485
1.68
3.54
2.7
2.8
0.80
0.81
mmol/l
0.80
66
458
205
1715
1.51
3.27
4.2
4.4
6.45
6.56
mmol/l
0.41
198
1620
138
1072
1.49
3.12
3.8
3.2
2.36
2.36
mmol/l
0.04
123
980
8
16
5.09
3.07
2.5
1.2
92.50
60.17
ng/l
—
8
16
96
699
1.53
2.92
2.1
1.7
0.88
1.15
mg/l
1.08
72
552
106
792
1.50
2.85
2.5
2.2
2.49
2.97
mg/l
1.63
95
683
56
362
1.66
2.81
4.0
4.8
31.37
32.43
%
0.33
38
234
69
474
1.58
2.71
1.9
1.9
—
—
—
0
0
9
29
3.16
2.24
1.0
1.0
—
—
—
0
0
97
747
1.42
2.16
3.4
2.6
324.67
325.94
umol/l
0.04
89
661
16
75
2.19
2.12
1.4
1.2
16.72
13.81
u/l
0.32
16
58
9
31
2.95
2.09
1.2
1.1
143.22
109.77
pmol/l
—
9
31
294
2749
1.62
2.06
7.5
6.3
39.15
38.91
mmol/mol
0.18
281
2593
28
163
1.78
2.06
2.3
1.7
—
—
—
0
0
158
1329
1.36
2.05
2.2
2.1
96.54
97.49
pmol/l
0.09
88
659
122
987
1.37
2.02
3.3
3.1
7.59
7.17
mmol/l
0.37
102
827
297
2787
1.64
2.01
17.0
14.8
80.79
81.80
ml/min/173m2
0.33
283
2587
5
11
4.60
1.95
2.2
2.8
0.63
0.62
mmol/l
—
5
11
185
1604
1.35
1.93
5.0
6.0
10.58
10.28
umol/l
0.11
171
1520
250
2281
1.39
1.82
5.0
4.4
11.72
11.88
mm/h
0.06
231
2119
81
627
1.39
1.73
3.7
2.7
2.45
2.46
mmol/l
0.03
70
568
12
55
2.23
1.69
1.1
1.5
—
—
—
0
0
111
913
1.32
1.59
2.2
2.1
128.93
163.07
u/l
0.60
104
867
223
2018
1.32
1.58
3.4
3.2
36.26
42.72
u/l
1.08
213
1900
16
85
1.93
1.58
1.6
1.4
—
—
—
0
0
116
965
1.31
1.53
4.0
3.9
19.26
8.07
mg/mmol
0.62
66
564
7
27
2.63
1.52
1.1
1.3
—
—
—
0
0
14
72
1.99
1.51
1.1
1.4
—
—
—
0
0
315
3038
1.76
1.41
14.3
11.6
23.35
24.51
u/l
0.82
309
2963
76
601
1.34
1.41
1.5
1.6
—
—
—
0
0
114
956
1.29
1.40
2.5
2.3
58.13
62.66
u/l
0.39
100
884
151
1325
1.26
1.26
13.6
11.2
1.23
1.18
inr
0.60
132
1081
8
36
2.25
1.25
1.3
1.2
—
72.20
—
0
5
314
3036
1.67
1.24
23.5
19.4
75.96
72.22
umol/l
0.99
314
3002
300
2873
1.47
1.24
18.8
14.9
20.75
21.00
mg/l
0.05
264
2339
14
78
1.83
1.23
1.5
1.4
—
—
—
0
0
5
19
2.66
1.22
2.8
2.4
—
—
—
0
0
67
538
1.31
1.13
3.7
3.8
42.88
200.00
ng/l
1.74
50
398
38
279
1.41
1.12
3.3
3.0
5.88
5.70
kpa
0.55
38
271
285
2724
1.33
1.02
4.7
4.2
1.28
1.26
mmol/l
0.27
268
2520
126
1108
1.22
0.98
4.0
3.8
88.15
89.00
ng/l
0.00
89
752
7
37
1.91
0.94
1.7
1.5
—
—
—
0
0
10
56
1.81
0.88
1.1
1.2
—
—
—
0
0
14
88
1.62
0.85
2.1
1.3
323.00
338.43
ug/g
—
9
50
72
846
0.81
0.84
4.3
3.0
0.26
0.36
e6/l
0.51
53
617
144
1302
1.19
0.81
6.2
4.3
36.51
36.08
g/l
0.50
135
1225
297
2876
1.32
0.78
5.6
5.1
4.80
4.75
mmol/l
0.40
282
2688
0
27
0.00
0.78
0.0
1.3
—
—
—
0
0
41
328
1.29
0.74
4.3
4.9
23.42
21.03
%
0.33
16
161
21
153
1.40
0.69
2.8
4.0
1.02
1.02
ratio
0.25
21
146
5
27
1.86
0.68
1.2
1.1
—
—
—
0
0
289
2798
1.26
0.68
5.7
5.1
5.87
5.88
mmol/l
0.08
269
2594
53
444
1.23
0.66
3.3
2.3
22.63
22.10
%
0.12
53
415
79
689
1.19
0.66
1.5
1.4
13.55
36.94
iu/ml
4.87
17
213
7
44
1.60
0.65
2.7
2.6
105.86
105.98
mmol/l
—
7
44
7
44
1.60
0.65
2.7
2.6
1.22
1.19
mmol/l
—
7
44
25
323
0.76
0.64
8.4
6.6
—
—
—
0
0
22
164
1.37
0.64
4.5
6.6
24.22
24.99
mmol/l
0.37
22
164
8
50
1.61
0.61
1.3
1.4
—
—
—
0
0
8
50
1.61
0.61
1.3
1.4
—
—
—
0
0
50
420
1.22
0.61
6.4
5.5
3.56
2.74
ug/l
0.26
44
376
0
20
0.00
0.60
0.0
1.0
—
—
—
0
0
198
1866
1.15
0.60
3.4
3.2
—
—
—
0
0
19
140
1.38
0.60
4.1
7.2
17.20
15.52
%
2.95
19
134
316
3104
1.40
0.57
30.4
23.0
90.89
91.11
fl
0.40
316
3078
5
89
0.56
0.56
1.2
1.2
—
—
—
0
0
8
55
1.47
0.56
1.0
1.1
—
—
—
0
0
316
3106
1.38
0.55
30.8
23.3
40.09
40.00
%
0.12
316
3079
316
3107
1.38
0.53
30.8
23.2
133.68
133.34
g/l
0.19
316
3080
43
362
1.22
0.53
1.8
1.8
—
—
—
0
0
299
2924
1.23
0.49
6.2
5.8
2.85
2.76
mmol/l
0.95
281
2723
113
1038
1.13
0.48
2.6
2.9
31.36
29.28
u/l
0.32
106
984
12
85
1.43
0.47
1.3
1.3
—
—
—
0
0
37
311
1.21
0.47
1.8
2.0
3.34
3.31
ratio
0.06
32
248
18
138
1.32
0.46
1.4
1.6
—
—
—
0
0
30
247
1.24
0.46
2.4
3.2
0.75
0.75
ug/l
0.00
19
163
102
934
1.13
0.46
4.2
3.4
0.04
0.01
estimate
0.32
26
294
10
69
1.46
0.44
1.2
1.1
5.94
1.85
u/ml
—
5
33
176
1668
1.12
0.44
4.7
4.1
0.00
0.01
estimate
0.50
32
347
12
162
0.73
0.43
5.0
6.4
23.13
25.01
mmol/l
0.95
12
154
5
31
1.62
0.43
3.8
3.4
—
—
—
0
0
5
31
1.62
0.43
1.2
1.2
—
—
—
0
0
6
92
0.65
0.43
4.5
2.6
24.98
24.57
mmol/l
—
6
92
40
343
1.19
0.42
1.8
1.8
—
—
—
0
0
8
58
1.39
0.42
1.1
1.2
—
—
—
0
0
16
123
1.32
0.41
2.1
1.6
—
—
—
0
0
174
1653
1.11
0.41
4.5
4.0
0.00
9.39
estimate
0.80
33
373
173
1643
1.11
0.41
4.5
4.0
0.00
0.00
estimate
0.50
33
361
0
17
0.00
0.41
0.0
2.6
—
189.12
—
0
17
293
2870
1.18
0.40
5.6
5.0
1.50
1.54
mmol/l
0.82
277
2668
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
5
35
1.43
0.39
1.0
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.4
—
—
—
0
0
55
489
1.15
0.38
1.8
1.7
888.66
1256.16
nmol/l
2.92
40
371
99
916
1.12
0.37
1.5
1.7
21.04
22.16
nmol/l
0.23
85
772
35
301
1.18
0.37
4.0
7.0
5.24
5.18
kpa
0.11
35
291
35
301
1.18
0.37
4.0
7.0
11.97
12.00
kpa
0.01
35
291
6
42
1.44
0.35
1.0
1.3
—
—
—
0
0
6
42
1.44
0.35
1.0
1.3
—
—
—
0
0
6
42
1.44
0.35
1.0
1.3
—
—
—
0
0
6
42
1.44
0.35
1.0
1.3
—
—
—
0
0
12
91
1.33
0.34
1.8
2.6
—
—
—
0
0
86
794
1.11
0.34
1.3
1.3
0.68
1.36
u/ml
1.43
24
227
72
658
1.12
0.34
1.6
1.5
—
—
—
0
0
6
45
1.34
0.34
2.0
3.8
18.83
56.74
u/ml
—
6
45
246
2399
1.10
0.29
24.0
19.4
331.17
331.29
g/l
0.08
246
2386
5
72
0.69
0.26
1.2
1.3
—
—
—
0
0
12
96
1.26
0.25
1.0
1.2
1.61
1.62
g/l
0.04
12
96
51
468
1.11
0.23
4.7
3.0
5.13
2.88
e6/l
0.56
28
219
5
41
1.22
0.22
1.0
1.3
—
—
—
0
0
5
41
1.22
0.22
1.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
110.45
—
0
11
0
11
0.00
0.21
0.0
1.8
—
101.55
—
0
11
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
7.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
8
101
0.79
0.21
6.1
2.5
4.08
0.53
g/l
—
8
94
15
177
0.84
0.21
1.1
1.3
—
—
—
0
0
28
249
1.14
0.21
4.7
7.6
122.43
120.76
g/l
0.19
28
244
15
126
1.20
0.21
3.3
4.3
1.34
1.52
%
0.86
15
117
8
104
0.76
0.21
2.8
2.1
9.21
10.25
g/l
—
8
98
0
12
0.00
0.21
0.0
4.8
—
4.68
—
0
12
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
4.7
—
10.55
—
0
12
86
908
0.93
0.21
4.5
4.1
0.00
0.01
estimate
0.74
31
345
6
48
1.25
0.20
1.2
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.5
—
—
—
0
0
37
337
1.11
0.20
2.5
2.4
8.52
6.28
umol/l
0.24
31
291
32
290
1.11
0.19
3.2
2.5
115.33
35.15
u/l
0.57
24
242
13
109
1.20
0.19
1.2
1.4
392.72
238.36
miu/ml
—
5
52
10
82
1.23
0.17
1.8
1.5
—
—
—
0
0
68
645
1.07
0.16
1.5
1.3
4.05
13.68
u/ml
2.22
23
255
12
102
1.18
0.15
1.0
1.2
0.85
0.92
g/l
0.41
12
102
128
1240
1.05
0.15
4.6
3.9
0.13
0.03
estimate
0.35
24
297
12
103
1.17
0.14
2.0
1.4
—
—
—
0
0
16
142
1.13
0.13
3.6
2.9
2.10
1.84
mmol/l
0.10
11
105
26
240
1.09
0.11
3.0
2.7
70.46
67.14
ml/min/173m2
0.14
13
95
34
319
1.07
0.11
2.5
4.2
2.76
43.24
ug/l
0.94
26
258
67
644
1.05
0.10
1.5
1.7
153333766.28
442.07
pmol/l
0.49
60
543
34
361
0.94
0.10
1.8
2.0
—
—
—
0
0
53
507
1.05
0.10
3.9
2.8
1.82
1.09
e6/l
0.28
30
257
5
44
1.14
0.10
1.0
1.4
0.76
0.60
nmol/l
—
5
39
129
1318
0.97
0.09
2.0
1.9
1.29
1.35
mmol/l
0.33
111
1116
28
298
0.93
0.09
2.9
3.3
—
—
—
0
0
5
61
0.82
0.08
1.8
1.8
—
—
—
0
0
5
62
0.80
0.08
1.2
1.4
—
—
—
0
0
17
156
1.09
0.08
1.6
1.4
—
—
—
0
0
7
68
1.03
0.08
1.7
1.8
—
—
—
0
0
12
108
1.12
0.07
1.3
1.9
—
—
—
0
0
24
255
0.94
0.07
1.5
1.5
—
—
—
0
0
7
82
0.85
0.07
1.0
1.2
—
55.26
—
0
7
7
84
0.83
0.07
1.0
1.4
—
—
—
0
0
8
92
0.87
0.07
1.5
1.2
—
—
—
0
0
8
93
0.86
0.07
2.8
2.3
0.00
0.05
g/l
—
8
88
25
236
1.06
0.06
1.6
1.8
3.58
3.46
mmol/l
0.28
20
168
11
99
1.11
0.06
1.3
1.2
—
—
—
0
0
31
324
0.95
0.06
1.6
1.9
—
—
—
0
0
71
693
1.03
0.05
5.1
4.0
1.02
1.02
kg/l
0.94
53
461
10
90
1.11
0.05
6.0
3.2
50.73
51.62
mg/l
—
10
78
10
90
1.11
0.05
6.0
3.3
34.84
29.03
mg/l
—
10
77
15
139
1.08
0.05
1.6
1.9
2.02
5.11
iu/ml
—
5
32
18
169
1.07
0.05
1.0
1.0
—
—
—
0
0
11
118
0.93
0.03
2.4
2.1
7.17
7.39
g/l
0.24
11
113
11
118
0.93
0.03
2.4
2.1
5.32
3.89
g/l
0.29
11
113
11
118
0.93
0.03
2.4
2.1
4.25
4.38
g/l
0.16
11
113
17
162
1.05
0.02
1.4
2.0
—
—
—
0
0
21
202
1.04
0.02
1.0
1.4
—
43.21
—
0
13
22
226
0.97
0.00
2.8
2.4
67.23
67.33
g/l
0.02
22
209
21
208
1.01
0.00
1.4
1.5
—
—
—
0
0
11
111
0.99
0.00
2.4
2.1
2.45
3.01
g/l
1.32
11
106
21
209
1.01
0.00
1.4
2.0
—
—
—
0
0
10
103
0.97
0.00
1.1
1.1
—
—
—
0
0
10
104
0.96
0.00
1.1
1.1
—
—
—
0
0
105
1055
0.99
0.00
4.7
3.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
5
50
1.00
-0.00
2.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
5
53
0.94
-0.00
1.8
2.3
16.62
16.33
%
—
5
53
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
89
1.01
-0.00
1.8
1.6
41.80
58.91
ug/l
—
9
74
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
1.19
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
67
0.89
-0.00
1.3
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.9
—
43.72
—
0
9
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
8
80
1.00
-0.00
1.1
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYTOXNOD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYTOXNOD | 1.287 [1.09, 1.53] | 0.004 |
| Birth year | 0.996 [0.99, 1.0] | 0.403 |
During the follow-up period (1.1.1998 — 31.12.2019), 211 out of 1340 females with E4_THYTOXNOD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYTOXNOD | 1.204 [0.89, 1.62] | 0.223 |
| Birth year | 0.987 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 68 out of 290 males with E4_THYTOXNOD died.
Mortality risk
Mortality risk for people of age
years, who have E4_THYTOXNOD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.172% | 0.275% |
| 5 | 0.855% | 1.442% |
| 10 | 2.072% | 3.605% |
| 15 | 3.994% | 6.787% |
| 20 | 6.997% | 11.648% |
Relationships between endpoints
↥Index endpoint: E4_THYTOXNOD – Thyrotoxicosis with toxic single thyroid nodule
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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