Hyperthyroidism: Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
131 |
4. Check minimum number of eventsNone |
131 |
5. Include endpointsNone |
131 |
6. Filter based on genotype QC (FinnGen only) |
118 |
Control definitions (FinnGen only)
- Control exclude
- THYROTOXICOSIS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E05
- Name in latin
- Thyreotoxicosis factitia
Similar endpoints
↥List of similar endpoints to
Thyrotoxicosis factitia
based on the number of shared cases.
Similar with more cases:
- Thyrotoxicosis, other and/or unspecified
- Thyrotoxicosis
- Disorders of thyroid, IBD co-morbidities
- Developmental endpoint to exclude non autoimmune-cases from E4_HYTHY_AI_STRICT
- Disorders of the thyroid gland
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 609 | 533 | 72 |
| Only index persons | 568 | 503 | 65 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.02 | 0.00 |
| Only index persons | 0.02 | 0.02 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 61.75 | 61.52 | 63.95 |
| Only index persons | 60.75 | 60.51 | 62.60 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 118 | 110 | 8 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.00 |
| Median age at first event (years) | 57.58 | 56.42 | 73.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 121
- Matched controls
- 1210
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E05.4
ICD-10 Finland
Thyrotoxicosis factitia
+∞
168.8
119
*
H03AA01
ATC
levothyroxine sodium; systemic
77.2
67.4
114
210
104
Kela drug reimbursment
Thyroid insufficiency
19.4
57.6
57
53
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
15.2
53.1
77
125
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
451.9
34.8
33
*
H03BB01
ATC
carbimazole; oral
149.6
32.5
33
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
+∞
21.5
20
*
E03.89
ICD-10 Finland
Other specified hypothyroidism
16.9
18.1
29
22
E03
ICD-10 Finland
Other hypothyroidism
6.1
14.4
29
59
BAA60
NOMESCO Finland
Total thyroidectomy
18.2
10.7
16
10
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
15.1
10.0
16
12
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
+∞
9.5
9
*
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
+∞
9.5
9
*
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
20.6
9.2
13
7
C07AA05
ATC
propranolol; systemic
3.3
9.0
48
200
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
8.4
8
*
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
+∞
7.4
7
*
C07AB07
ATC
bisoprolol; oral
2.8
6.9
73
429
M01AH01
ATC
celecoxib; oral
3.1
6.8
36
147
T86
ICPC
Hypothyroidism/myxoedema
6.9
6.7
16
26
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
3.0
6.2
34
141
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.8
6.0
41
190
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
66
56
24.73
71.54
7.8
1.9
4.64
4.36
pmol/l
0.51
60
47
46
120
5.57
17.77
2.2
2.1
329.90
380.82
nmol/l
1.06
39
114
36
92
5.15
13.93
1.3
1.3
264.73
137.89
u/ml
0.66
16
37
91
559
3.53
8.68
8.9
6.5
1.22
1.22
mmol/l
0.13
74
478
51
225
3.19
8.64
1.9
1.7
466.35
478.62
pmol/l
0.11
40
186
75
413
3.15
8.61
2.8
3.1
2.34
2.37
mmol/l
0.58
69
382
88
549
3.21
7.79
3.0
2.5
80.99
78.04
nmol/l
0.40
79
495
89
561
3.22
7.69
3.8
3.1
82.43
83.45
ug/l
0.04
82
519
41
172
3.09
7.41
2.6
2.1
14.32
12.96
umol/l
0.59
36
160
72
411
2.86
7.35
5.8
4.0
17.48
35.40
ng/l
1.03
50
269
80
485
2.92
7.24
2.5
2.0
99.77
98.50
pmol/l
0.07
44
223
62
330
2.80
7.20
1.7
1.6
16.98
22.19
nmol/l
2.52
53
276
65
356
2.78
7.12
3.0
2.2
145.47
141.16
u/l
0.05
60
340
95
638
3.28
7.03
7.5
10.1
3.78
3.96
e9/l
0.33
85
559
92
618
3.04
6.59
5.9
5.1
6.79
6.51
mmol/l
0.50
87
580
38
173
2.74
5.76
1.8
1.6
1228.26
1180.54
nmol/l
0.13
29
125
52
277
2.54
5.74
2.7
2.1
2.81
2.92
mg/l
0.14
39
232
58
328
2.48
5.60
4.3
3.5
1255.00
912.78
ng/l
0.34
48
272
33
150
2.65
4.95
1.9
1.8
29.15
29.04
s
0.04
33
145
62
379
2.30
4.84
3.0
3.2
28.79
28.87
u/l
0.01
56
359
75
508
2.25
4.44
7.1
6.1
1.21
1.22
mmol/l
0.54
70
462
11
24
4.93
3.85
9.9
3.3
7.49
6.89
mmol/l
0.38
11
24
12
29
4.47
3.82
9.3
3.1
1.21
1.37
mmol/l
0.54
12
29
6
5
12.52
3.80
2.3
1.2
7.10
10.20
umol/l
—
6
5
9
16
5.98
3.73
4.4
2.9
106.11
108.19
mmol/l
—
9
16
9
16
5.98
3.73
4.4
2.9
1.21
1.20
mmol/l
—
9
16
19
75
2.82
3.67
2.0
1.5
—
—
—
0
0
54
343
2.04
3.54
5.2
3.4
0.00
0.01
estimate
0.49
25
91
58
380
2.01
3.48
3.4
3.4
—
—
—
0
0
67
464
1.99
3.41
6.0
3.8
0.00
0.00
estimate
-0.00
21
94
51
323
2.00
3.33
3.3
3.0
0.14
0.52
e6/l
2.40
39
231
17
67
2.79
3.29
3.9
2.6
1.25
1.22
%
0.03
17
67
115
1020
3.57
3.17
22.4
15.7
81.79
81.69
ml/min/173m2
0.02
110
927
48
303
1.97
3.13
1.7
1.3
0.70
1.54
u/ml
0.82
16
76
9
21
4.54
3.06
2.2
2.6
10.53
6.37
pmol/l
—
9
21
16
65
2.68
2.93
3.9
2.6
0.73
0.58
%
1.34
16
65
31
171
2.09
2.90
1.6
1.9
—
—
—
0
0
93
753
2.02
2.70
4.2
3.1
37.66
41.09
u/l
0.29
88
711
81
627
1.88
2.69
5.9
4.1
0.00
0.00
estimate
-0.00
27
115
115
1033
3.28
2.69
7.0
5.0
6.13
5.81
mmol/l
1.07
107
949
80
620
1.86
2.61
5.9
4.0
0.00
0.00
estimate
-0.00
29
116
17
76
2.44
2.58
1.3
1.4
—
—
—
0
0
16
70
2.48
2.54
5.4
6.5
25.96
25.36
mmol/l
0.30
16
70
15
64
2.53
2.50
1.1
1.0
—
—
—
0
0
80
626
1.82
2.46
5.9
4.0
0.00
13.53
estimate
0.50
28
120
22
113
2.16
2.45
5.4
7.5
0.27
1.26
mmol/l
0.79
16
95
41
264
1.84
2.42
1.9
1.8
0.51
1.33
mg/l
2.44
33
218
8
22
3.82
2.41
1.3
1.2
—
—
—
0
0
10
34
3.11
2.34
1.6
1.1
—
—
—
0
0
48
329
1.76
2.29
5.8
4.3
0.00
0.00
estimate
-0.00
26
110
116
1066
3.13
2.20
24.2
15.8
13.68
21.41
mg/l
4.41
105
851
6
14
4.45
2.18
1.2
1.2
—
—
—
0
0
6
14
4.45
2.18
1.5
1.2
—
—
—
0
0
48
345
1.65
1.86
5.0
3.6
1.65
6.31
mg/mmol
1.83
26
201
111
999
2.34
1.85
9.8
6.1
40.37
38.78
mmol/mol
0.77
102
931
25
149
1.85
1.85
6.7
6.4
104.56
104.07
mmol/l
0.17
25
149
35
234
1.70
1.77
1.4
1.3
1.77
9.15
u/ml
1.61
17
94
10
41
2.57
1.69
1.3
1.3
—
—
—
0
0
18
99
1.96
1.68
5.3
3.8
—
—
—
0
0
18
99
1.96
1.68
8.1
2.8
4.77
4.26
kpa
0.87
18
99
7
25
2.91
1.67
1.6
1.5
—
—
—
0
0
20
116
1.87
1.61
1.4
1.9
—
—
—
0
0
10
44
2.39
1.60
2.1
1.7
0.79
6.91
ug/l
—
10
38
29
191
1.68
1.54
2.1
2.8
0.78
0.77
e6/l
0.01
18
99
35
243
1.62
1.52
1.8
1.6
—
—
—
0
0
20
119
1.82
1.49
1.5
1.8
—
—
—
0
0
35
245
1.60
1.46
1.5
1.3
22.33
33.51
iu/ml
—
9
79
12
60
2.11
1.43
1.1
1.8
—
—
—
0
0
9
40
2.35
1.43
1.2
1.2
—
—
—
0
0
9
40
2.35
1.43
1.1
1.9
—
—
—
0
0
9
40
2.35
1.43
1.2
1.2
—
—
—
0
0
9
41
2.29
1.40
1.1
2.0
—
—
—
0
0
5
17
3.02
1.37
1.0
1.4
—
—
—
0
0
8
36
2.31
1.27
2.9
2.4
23.00
25.32
mmol/l
—
8
36
5
19
2.70
1.23
1.0
1.3
—
—
—
0
0
26
177
1.60
1.21
2.2
2.9
6.09
3.99
e6/l
0.38
15
86
101
915
1.63
1.17
29.0
19.3
13.54
13.60
%
0.19
101
907
9
45
2.08
1.07
1.3
1.4
—
—
—
0
0
37
282
1.45
1.03
5.6
3.9
1.02
1.02
kg/l
0.02
29
174
0
31
0.00
0.98
0.0
1.6
—
1.34
—
0
19
0
31
0.00
0.98
0.0
1.6
—
1.24
—
0
19
0
31
0.00
0.98
0.0
1.6
—
0.92
—
0
19
15
95
1.66
0.92
1.9
1.4
—
—
—
0
0
11
64
1.79
0.89
6.3
9.5
94.45
94.76
%
0.11
11
64
35
272
1.40
0.87
2.0
2.8
329.27
318.69
umol/l
0.35
26
239
112
1060
1.76
0.85
6.4
5.0
4.72
4.74
mmol/l
0.06
102
980
17
117
1.53
0.77
9.4
6.8
—
—
—
0
0
5
24
2.13
0.75
2.6
1.3
1021.80
2638.50
e6/l
—
5
18
5
24
2.13
0.75
1.2
1.3
—
—
—
0
0
60
518
1.31
0.74
2.9
2.7
—
—
estimate
—
0
0
9
56
1.66
0.74
1.6
1.3
—
—
—
0
0
28
215
1.39
0.74
6.2
3.9
42.48
300.71
ng/l
1.11
21
163
5
25
2.04
0.73
1.2
1.5
—
—
—
0
0
5
25
2.04
0.73
1.0
1.2
—
—
—
0
0
41
486
0.76
0.67
2.2
1.9
1.45
1.31
mmol/l
0.46
29
411
7
44
1.63
0.66
2.3
1.7
—
—
—
0
0
112
1071
1.61
0.65
7.2
5.7
2.69
2.74
mmol/l
0.22
102
985
5
30
1.69
0.62
1.2
1.1
—
6.30
—
0
6
0
22
0.00
0.60
0.0
1.6
—
—
—
0
0
105
995
1.42
0.59
5.7
4.2
1.41
1.21
mmol/l
1.56
96
906
10
68
1.51
0.48
2.6
3.4
25.24
24.66
mmol/l
—
10
68
8
55
1.49
0.44
1.4
1.4
—
—
—
0
0
0
16
0.00
0.41
0.0
1.4
—
55.17
—
0
16
0
18
0.00
0.40
0.0
1.7
—
—
—
0
0
5
35
1.45
0.40
1.8
1.3
136.02
130.48
ug/l
—
5
30
109
1056
1.32
0.34
6.6
4.9
1.48
1.58
mmol/l
1.30
100
970
23
271
0.81
0.34
1.6
1.5
—
—
—
0
0
9
76
1.20
0.25
2.1
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
72
702
1.06
0.08
2.8
3.3
—
—
—
0
0
11
100
1.11
0.05
2.5
1.8
—
—
—
0
0
27
264
1.03
0.00
2.2
2.2
—
—
—
0
0
15
153
0.98
0.00
3.2
2.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
431.00
—
0
8
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
11.00
—
0
5
0
7
0.00
-0.00
0.0
5.0
—
0.14
—
0
7
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
117.20
—
0
5
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
14
140
1.00
-0.00
3.1
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
84.94
—
0
5
0
8
0.00
-0.00
0.0
1.1
—
19.25
—
0
8
0
5
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
0.30
—
0
5
0
8
0.00
-0.00
0.0
1.1
—
56.88
—
0
8
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
9.29
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
37.35
—
0
6
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYTOXFAC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_THYTOXFAC | 1.608 [1.15, 2.24] | 0.005 |
| Birth year | 0.997 [0.99, 1.01] | 0.534 |
During the follow-up period (1.1.1998 — 31.12.2019), 95 out of 465 females with E4_THYTOXFAC died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have E4_THYTOXFAC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.149% | No data |
| 5 | 1.053% | No data |
| 10 | 2.484% | No data |
| 15 | 4.999% | No data |
| 20 | 8.612% | No data |
Relationships between endpoints
↥Index endpoint: E4_THYTOXFAC – Thyrotoxicosis factitia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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