protein energy malnutrition: A nutritional deficit that is caused by inadequate protein or calorie intake.
Protein-energy malnutrition of moderate and mild degree
DOID EFO Endpoint Browser PheWeb
E4_PROTMALMODMILD
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
375 |
4. Check minimum number of eventsNone |
375 |
5. Include endpointsNone |
375 |
6. Filter based on genotype QC (FinnGen only) |
335 |
Control definitions (FinnGen only)
- Control exclude
- E4_MALNUTRITION
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E40-E46
- Name in latin
- Malnutritio moderata sive levis ex deficientia proteino-energetica
Similar endpoints
↥List of similar endpoints to
Protein-energy malnutrition of moderate and mild degree
based on the number of shared cases.
Similar with more cases:
- Malnutrition
- Endocrine, nutritional and metabolic diseases
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3200 | 1841 | 1349 |
| Only index persons | 2726 | 1607 | 1119 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.04 |
| Only index persons | 0.05 | 0.06 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 65.21 | 68.83 | 60.28 |
| Only index persons | 68.06 | 71.33 | 63.35 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 335 | 187 | 148 |
| Unadjusted period prevalence (%) | 0.07 | 0.07 | 0.07 |
| Median age at first event (years) | 69.26 | 68.52 | 70.20 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 354
- Matched controls
- 3539
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E44.0
ICD-10 Finland
Moderate protein-energy malnutrition
+∞
293.0
239
*
E44.1
ICD-10 Finland
Mild protein-energy malnutrition
+∞
125.7
113
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.3
39.0
150
515
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
7.2
30.7
49
77
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
12.0
30.6
32
29
R63.4
ICD-10 Finland
Abnormal weight loss
6.6
25.4
44
75
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.6
24.1
98
336
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.3
23.0
113
435
ZXD05
NOMESCO Finland
Urgent procedure
2.9
21.3
152
721
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.8
20.0
173
901
SPAT1262
SPAT
Handing over of treatment supplies
3.1
18.8
97
380
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
4.5
17.2
45
111
E86
ICD-10 Finland
Volume depletion
6.5
16.6
28
46
ZXE00
NOMESCO Finland
One hour or less
2.5
16.5
179
1016
OAB73
NOMESCO Finland
Prevention and treatment of malnutrition
19.7
16.2
24
13
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
17.1
15.5
24
15
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.5
15.1
58
188
SPAT1229
SPAT
Assessment of need for aid
3.6
14.9
54
168
NE1AA
NOMESCO Finland
Pelvis X-ray examination
3.4
14.8
59
196
R53
ICD-10 Finland
Malaise and fatigue
2.5
14.7
134
693
R4190
NOMESCO Finland
Nutritional therapy
4.0
14.7
44
120
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.8
14.5
89
379
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.5
14.2
36
86
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.5
14.2
53
168
SPAT1249
SPAT
Treatment-related counselling outside office
2.3
13.6
166
970
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.3
13.6
206
1321
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.4
13.4
133
710
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.4
13.3
141
775
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
5.5
12.7
25
48
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.4
12.6
50
165
EBA15
NOMESCO Finland
Extraction of multiple teeth
4.7
12.4
30
69
ZXE10
NOMESCO Finland
More than one and less than three hours
2.2
11.9
155
919
NF1AA
NOMESCO Finland
Hip X-ray examination
3.1
11.9
55
199
JN4AD
NOMESCO Finland
Body CT examination
3.0
11.8
59
223
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
3.9
11.8
37
104
130
Kela drug reimbursment
Malignant tumour
3.1
11.5
53
191
SPAT1301
SPAT
No procedures
2.2
11.5
144
838
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
5.5
11.2
22
42
NFB20
NOMESCO Finland
Primary partial prosthetic replacement of hip joint using cement, other or unspecified
4.9
11.1
25
54
I95.1
ICD-10 Finland
Orthostatic hypotension
4.1
11.1
31
80
AA1AD
NOMESCO Finland
CT of head and brain
2.2
11.0
136
783
N02AA05
ATC
oxycodone; systemic
2.4
11.0
98
492
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.7
10.9
70
301
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
3.8
10.6
34
97
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.5
10.6
76
346
S72.0
ICD-10 Finland
Fracture of neck of femur
3.8
10.5
33
93
S01.0
ICD-10 Finland
Open wound of scalp
3.1
10.4
47
167
Z51.5
ICD-10 Finland
Palliative care
2.9
10.2
53
204
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.1
10.2
149
911
R1250, ,
SPAT
4.3
10.2
27
67
TPH07
NOMESCO Finland
Cathetrisation of artery
2.6
10.0
63
268
R4180
NOMESCO Finland
Podiatric therapy
10.0
9.9
19
20
B03BA03
ATC
hydroxocobalamin; parenteral
3.4
9.7
36
113
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.6
9.7
65
285
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.9
9.6
48
181
NB1BA
NOMESCO Finland
Shoulder extensive X-ray examination without contrast
4.4
9.5
24
57
D64.9
ICD-10 Finland
Anaemia, unspecified
2.6
9.5
62
269
M80.0
ICD-10 Finland
Postmenopausal osteoporosis with pathological fracture
5.1
9.4
20
41
SPAT1310
SPAT
Counselling related to known health issue
2.1
9.4
135
814
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
4.4
9.3
24
58
602
Kela drug reimbursment
Children's severe malnutrition
8.1
9.3
20
26
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
8.7
9.2
19
23
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
5.0
9.2
20
42
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
4.5
9.0
22
51
L30.3
ICD-10 Finland
Infective dermatitis
5.1
8.9
19
39
JDB10
NOMESCO Finland
Percutaneous gastrostomy
9.9
8.9
17
18
A03FA01
ATC
metoclopramide; systemic, rectal
2.2
8.8
92
489
OAB50, ,
SPAT
3.0
8.8
41
148
T36
ICD-10 Finland
Poisoning by systemic antibiotics
4.6
8.7
21
48
SPAT1263
SPAT
Sampling
2.0
8.7
166
1099
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
3.2
8.7
35
116
SPAT1312
SPAT
General health counselling
2.0
8.7
136
842
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.6
8.6
54
229
RD210, ,
NOMESCO Finland
4.5
8.5
21
49
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
2.8
8.5
45
175
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.1
8.5
37
129
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.5
8.4
60
270
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.7
8.4
27
77
S42.0
ICD-10 Finland
Fracture of clavicle
4.4
8.3
21
50
R11
ICD-10 Finland
Nausea and vomiting
2.6
8.3
54
233
XX3DW
NOMESCO Finland
Time consuming IT work
2.6
8.3
51
214
OAB74
NOMESCO Finland
Nutritional guidance related to treatment and rehabilitation for medical condition
9.2
8.1
16
18
E55.9
ICD-10 Finland
Vitamin D deficiency, unspecified
22.6
8.1
11
5
E87.6
ICD-10 Finland
Hypokalaemia
3.9
8.0
24
65
ZY010
NOMESCO Finland
Hospital outpatient
3.3
7.9
30
96
R50.9
ICD-10 Finland
Fever, unspecified
2.2
7.9
78
405
S97
ICPC
Chronic ulcer skin
2.9
7.8
39
147
A02BC02
ATC
pantoprazole; systemic
1.9
7.8
235
1788
R1100, ,
SPAT
10.4
7.6
14
14
W19
ICD-10 Finland
Unspecified fall
2.4
7.6
56
256
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
3.0
7.6
35
126
SPAT1153
SPAT
Removal of sutures
1.9
7.5
119
732
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
4.6
7.5
18
41
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
7.9
7.5
16
21
TGC00
NOMESCO Finland
Bronchial lavation
4.2
7.4
20
50
TJD20
NOMESCO Finland
Change of gastrostomy tube
13.7
7.4
12
9
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.9
7.4
37
139
WX302
NOMESCO Finland
Thoracal epidural anesthesy
3.5
7.4
26
79
F10.2
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Dependence syndrome
11.2
7.4
13
12
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.3
7.3
62
301
E42
ICD-10 Finland
Marasmic kwashiorkor
+∞
7.3
7
*
GD1AD
NOMESCO Finland
Thorax CT examination
3.0
7.3
34
123
M81.9
ICD-10 Finland
Osteoporosis, unspecified
3.2
7.3
30
101
JN3AD
NOMESCO Finland
Abdominal CT examination
2.4
7.3
56
261
P15
ICPC
Chronic alcohol abuse
4.6
7.3
17
38
-44
ICPC
Preventive immunization/medic
2.6
7.3
43
177
A04
ICPC
Weakness/tiredness general
2.1
7.2
77
410
N05AX08
ATC
risperidone; systemic
2.4
7.0
49
218
SPAT1245
SPAT
Provision of support and information to patient’s family members
3.1
7.0
30
103
ZY000
NOMESCO Finland
Hospital inpatient
9.6
6.8
13
14
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.1
6.8
73
390
W17
ICD-10 Finland
Other fall from one level to another
3.9
6.7
20
54
WX402
NOMESCO Finland
General anaesthesia
2.0
6.7
87
497
F50.9
ICD-10 Finland
Eating disorder, unspecified
8.9
6.6
13
15
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
2.7
6.6
37
148
N05AH03
ATC
olanzapine; systemic
3.1
6.6
28
96
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.1
6.5
27
91
SHA03
NOMESCO Finland
Stomatognathic treatment, demanding
4.1
6.5
18
46
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.7
6.5
35
137
SPAT1234
SPAT
Support of social functional capacity
2.9
6.5
31
114
JDD00
NOMESCO Finland
Total gastrectomy and Roux-en-Y oesophagojejunostomy
71.1
6.4
7
*
SPAT1053
SPAT
Memory test
2.1
6.4
68
361
F10.25
ICD-10 Finland
Alcohol dependence continuous use
8.4
6.4
13
16
WZC00
NOMESCO Finland
Treatment plan or consultation
1.8
6.3
139
939
JCA55
NOMESCO Finland
Endoscopic dilatation of oesophagus
11.3
6.3
11
10
L28
ICPC
Limited function/disability (L)
1.9
6.3
88
515
E41
ICD-10 Finland
Nutritional marasmus
+∞
6.3
6
*
N03AX09
ATC
lamotrigine; oral
3.3
6.3
23
72
R41.0
ICD-10 Finland
Disorientation, unspecified
3.4
6.2
22
67
N07BA03
ATC
varenicline; oral
4.1
6.2
17
43
NFJ54
NOMESCO Finland
Internal fixation of fracture of upper femur with intramedullary nail
5.5
6.2
17
32
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.3
6.2
47
217
Z2446
NOMESCO Finland
Social worker
2.4
6.1
44
199
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.9
6.0
81
468
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
162
324
8.37
86.38
3.2
2.8
0.17
0.21
g/l
7.88
151
305
166
558
4.72
45.53
8.3
5.5
0.79
0.81
mmol/l
1.10
155
521
104
259
5.27
40.89
7.3
4.5
1.20
1.23
mmol/l
4.23
94
227
52
63
9.50
40.88
5.0
3.8
4.99
4.96
kpa
0.10
52
63
154
526
4.41
40.56
10.1
7.7
1.09
1.13
mmol/l
0.66
145
482
266
1404
4.60
36.78
8.7
5.7
31.59
35.31
g/l
16.41
256
1310
109
333
4.28
32.46
8.3
3.7
—
—
—
0
0
202
944
3.65
31.93
3.3
2.6
3.29
2.91
mg/l
1.01
179
818
248
1400
3.57
27.50
4.1
2.9
70.99
76.98
nmol/l
2.70
238
1249
177
817
3.33
27.46
3.6
3.1
5.28
5.34
e6/l
0.03
170
741
193
955
3.24
26.33
2.2
1.8
19.74
21.11
nmol/l
0.57
168
794
133
530
3.42
26.03
3.2
2.8
20.06
21.72
%
0.40
122
497
41
64
7.11
25.76
1.7
2.0
—
—
—
0
0
43
71
6.75
25.64
1.6
2.0
—
—
—
0
0
137
561
3.35
25.58
3.2
2.8
2.11
2.30
g/l
2.38
128
520
209
1107
3.17
24.92
3.4
3.3
2.32
2.36
mmol/l
3.56
194
1004
150
660
3.21
24.68
2.6
1.8
428.32
12226723.43
pmol/l
0.50
118
548
38
58
7.22
24.34
1.8
2.0
—
—
—
0
0
139
601
3.16
23.33
3.4
2.8
10.51
12.56
umol/l
0.85
129
561
27
29
9.99
22.91
1.5
1.7
—
—
—
0
0
269
1707
3.40
22.39
14.3
8.4
1.20
1.21
mmol/l
1.25
196
1491
137
600
3.09
22.32
3.0
1.7
1619.27
1198.84
nmol/l
3.69
97
449
53
122
4.93
22.13
2.3
1.8
3.28
4.59
ug/l
0.16
47
104
253
1561
3.17
21.88
15.3
8.0
1.20
1.22
mmol/l
3.67
242
1440
48
103
5.23
21.73
1.9
1.9
—
—
—
0
0
59
156
4.34
20.70
9.9
15.3
1.39
1.41
mg/l
0.11
51
140
48
109
4.94
20.32
1.9
2.0
—
—
—
0
0
254
1608
3.05
20.24
8.6
6.7
12.58
12.14
umol/l
0.12
243
1527
239
1471
2.92
19.95
20.3
16.5
1.25
1.31
inr
1.22
220
1228
236
1450
2.88
19.63
4.3
3.4
253.03
116.45
ug/l
0.73
209
1343
92
344
3.26
19.31
18.2
11.7
25.55
24.71
mmol/l
1.15
92
344
130
600
2.84
18.70
2.5
2.0
—
—
—
0
0
208
1234
2.66
17.93
4.2
4.1
—
—
—
0
0
273
1867
3.02
17.59
11.0
6.0
6.66
6.65
mmol/l
0.03
267
1766
197
1153
2.60
17.24
3.9
4.1
268.57
107.05
e6/l
0.44
176
902
170
928
2.60
17.21
6.5
4.7
0.00
0.01
estimate
0.50
92
316
65
210
3.57
17.07
9.9
9.3
8.72
9.24
kpa
1.13
60
202
170
948
2.53
16.20
3.3
2.6
53.98
68.02
u/l
1.27
155
877
266
1843
2.78
15.79
11.5
10.8
4.59
4.07
e9/l
2.43
241
1584
197
1191
2.47
15.55
7.0
4.5
40.30
67.73
ng/l
0.51
172
935
216
1371
2.48
15.17
2.7
2.2
86.27
95.21
pmol/l
2.20
137
706
169
965
2.44
14.98
3.3
2.2
198.98
223.48
u/l
0.18
153
921
174
1010
2.42
14.83
4.0
4.0
0.44
0.38
e6/l
0.20
157
759
93
403
2.77
14.64
4.1
4.5
248.99
243.87
u/l
0.16
82
382
28
53
5.65
14.43
2.2
2.5
32.39
32.51
pg
0.04
28
53
204
1289
2.37
14.09
4.5
5.0
164.92
125.06
e6/l
0.24
181
931
33
74
4.81
14.08
1.7
1.6
—
—
—
0
0
296
2230
3.00
13.82
11.7
8.1
98.67
86.72
u/l
2.21
288
2101
38
98
4.22
13.63
2.6
3.4
1.46
3.31
ratio
1.13
17
55
73
288
2.93
13.61
2.9
2.5
64.35
65.91
g/l
0.69
66
262
75
304
2.86
13.29
9.5
7.9
1.83
1.47
mmol/l
0.27
58
220
36
92
4.24
13.06
1.4
1.5
269.63
289.69
ug/g
0.19
22
60
35
88
4.30
12.96
1.8
1.6
—
—
—
0
0
38
105
3.93
12.41
2.6
3.5
49.27
114.50
mg/l
0.57
17
88
38
105
3.93
12.41
2.6
3.5
39.56
50.81
mg/l
0.21
17
88
32
80
4.30
11.93
1.9
1.3
—
—
—
0
0
28
63
4.74
11.88
1.5
1.7
—
—
—
0
0
216
1463
2.22
11.81
29.6
13.6
0.00
0.00
e9/l
0.29
188
1177
34
90
4.07
11.76
2.3
1.5
—
—
—
0
0
25
52
5.10
11.61
1.6
1.8
—
—
—
0
0
39
116
3.65
11.46
2.6
2.6
—
—
—
0
0
191
1243
2.16
11.42
6.2
4.6
0.00
0.02
estimate
1.15
83
289
94
463
2.40
11.05
2.2
2.0
—
—
—
0
0
273
2080
2.36
10.60
7.4
5.6
40.27
3851.22
e6/l
1.65
11
41
149
902
2.12
10.52
6.2
4.0
0.59
0.01
estimate
0.49
85
277
89
439
2.37
10.36
2.3
2.1
—
—
—
0
0
48
177
2.98
9.98
1.6
1.5
—
—
—
0
0
117
669
2.12
9.39
3.1
2.9
2.49
2.46
mmol/l
1.17
104
601
284
2249
2.33
9.29
5.8
4.3
15.60
14.98
pmol/l
2.63
257
2022
54
221
2.70
9.25
2.9
3.3
55.13
61.79
ml/min/173m2
0.58
23
99
227
1660
2.02
9.04
5.9
4.7
0.00
0.00
estimate
-0.00
101
345
17
18
9.86
8.87
1.5
1.7
—
—
—
0
0
233
1727
2.02
8.84
5.3
3.7
83.13
46.02
u/l
1.84
215
1609
36
121
3.20
8.74
1.5
1.4
—
—
—
0
0
196
1375
1.95
8.66
4.0
3.0
—
—
estimate
—
0
0
227
1674
1.99
8.66
5.9
4.7
0.00
9.81
estimate
0.80
102
357
17
19
9.33
8.63
1.5
1.7
—
—
—
0
0
228
1687
1.99
8.57
6.0
4.7
0.00
0.01
estimate
0.50
100
329
18
37
5.07
8.45
1.6
1.6
—
—
—
0
0
131
807
1.99
8.42
1.7
1.5
1.16
1.88
u/ml
0.81
45
187
17
21
8.44
8.18
1.5
1.7
—
—
—
0
0
27
80
3.57
7.97
6.7
10.5
436.40
136.42
iu/ml
—
5
12
275
2205
2.11
7.87
6.0
4.8
17.89
12.58
mm/h
4.54
251
2034
34
118
3.08
7.83
2.6
2.2
231.46
328.31
ug/l
0.60
26
109
17
38
4.65
7.25
4.4
3.8
—
—
—
0
0
12
12
10.30
6.58
2.8
7.1
—
—
—
0
0
52
255
2.22
5.97
2.2
1.8
—
—
—
0
0
136
940
1.72
5.57
4.1
3.5
69.84
32.82
u/l
0.58
127
889
304
2638
2.08
5.52
7.2
5.4
2.05
1.99
mu/l
0.33
282
2405
147
1044
1.70
5.42
5.1
3.9
1954.06
1560.55
ng/l
0.65
128
905
55
289
2.07
5.29
3.8
5.5
70.17
76.95
ng/l
0.27
41
255
38
174
2.33
5.12
3.9
2.7
4.09
4.55
pmol/l
1.48
33
152
37
168
2.34
5.08
1.4
2.1
1.36
1.53
g/l
0.50
28
151
80
485
1.84
5.07
10.8
6.5
6.34
5.71
kpa
4.31
74
469
51
266
2.07
5.00
2.0
1.9
2.10
1.55
%
1.10
42
226
324
2918
2.30
4.74
17.7
12.7
26.34
23.81
u/l
0.56
317
2833
221
1785
1.63
4.67
3.0
3.2
—
—
—
0
0
7
5
14.24
4.59
1.4
1.4
—
—
—
0
0
320
2878
2.16
4.53
36.5
18.4
27.10
25.30
mg/l
0.55
304
2373
76
474
1.77
4.34
11.3
6.6
2.58
1.52
mmol/l
1.56
63
391
11
20
5.64
4.32
1.2
1.2
60.35
31.67
mg/l
—
6
15
7
8
8.89
3.79
1.3
1.6
—
—
—
0
0
62
383
1.75
3.64
15.0
7.4
1.78
0.90
mmol/l
1.01
48
320
68
437
1.69
3.46
11.6
6.4
4.56
4.80
kpa
0.50
63
422
44
250
1.87
3.39
9.7
5.5
121.97
127.76
g/l
1.04
38
243
11
29
3.88
3.21
1.1
1.3
—
—
—
0
0
15
55
2.80
3.19
1.5
1.3
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
21
92
2.36
3.16
25.6
3.8
0.39
0.36
iu/ml
0.16
15
53
331
3093
2.08
2.98
51.9
27.6
4.11
4.42
e12/l
18.13
326
2999
12
43
2.85
2.67
1.6
1.2
—
—
—
0
0
17
74
2.36
2.62
2.8
3.2
1.05
0.95
nmol/l
0.21
11
59
9
25
3.66
2.59
1.1
1.1
—
—
—
0
0
39
234
1.75
2.55
12.8
7.8
24.64
24.42
mmol/l
0.22
39
224
21
102
2.12
2.52
2.4
2.8
—
—
—
0
0
10
32
3.18
2.45
1.3
1.0
—
—
—
0
0
10
32
3.18
2.45
1.3
1.0
—
—
—
0
0
277
2504
1.49
2.45
33.9
18.1
80.62
77.10
ml/min/173m2
1.53
268
2296
9
27
3.39
2.41
1.2
1.0
—
—
—
0
0
36
217
1.73
2.33
1.8
1.8
—
—
—
0
0
9
28
3.27
2.32
1.0
1.1
—
—
—
0
0
6
13
4.67
2.28
1.0
1.1
—
—
—
0
0
7
18
3.94
2.26
1.1
1.0
—
—
—
0
0
21
107
2.02
2.25
2.0
1.8
—
—
—
0
0
16
73
2.25
2.24
1.8
1.9
102.60
125.24
au/ml
—
5
30
5
9
5.61
2.22
1.0
1.4
—
—
—
0
0
54
368
1.55
2.18
5.3
3.7
14.60
6.96
umol/l
0.71
43
327
276
2513
1.44
2.17
6.9
6.9
38.85
39.72
mmol/mol
0.69
250
2337
11
42
2.67
2.16
1.4
1.6
—
—
—
0
0
11
42
2.67
2.16
2.4
1.8
—
—
—
0
0
22
116
1.96
2.16
2.1
1.9
—
—
—
0
0
6
14
4.34
2.16
1.3
1.3
—
—
—
0
0
12
49
2.50
2.12
2.3
1.7
—
—
—
0
0
283
2594
1.45
2.10
5.2
5.3
5.88
5.98
mmol/l
0.28
240
2338
16
76
2.16
2.05
1.8
1.9
—
—
—
0
0
9
32
2.86
2.01
1.0
1.5
—
—
—
0
0
15
71
2.16
1.95
1.7
1.4
—
—
—
0
0
42
278
1.58
1.93
2.7
2.7
4.24
8.23
ug/l
1.37
35
247
89
686
1.40
1.93
4.0
2.1
1.72
1.43
mg/l
0.52
70
533
8
28
2.90
1.87
1.6
1.3
—
—
—
0
0
17
87
2.00
1.83
1.6
1.3
—
—
—
0
0
42
282
1.55
1.82
2.5
3.0
0.16
0.72
e6/l
0.97
42
272
6
18
3.37
1.75
1.2
1.4
—
—
—
0
0
21
118
1.83
1.74
1.9
1.6
—
—
—
0
0
7
24
2.95
1.73
2.9
2.0
—
—
—
0
0
5
13
3.88
1.72
4.4
5.2
—
—
—
0
0
13
248
0.51
1.65
2.0
1.5
—
—
—
0
0
10
42
2.42
1.63
1.5
1.1
—
—
—
0
0
5
14
3.61
1.62
8.4
2.5
148.00
135.36
nmol/l
—
5
14
5
14
3.61
1.62
2.0
1.7
69.00
64.71
umol/l
—
5
14
13
63
2.10
1.61
1.2
1.4
—
—
—
0
0
14
70
2.04
1.61
3.1
2.5
219.40
80.74
ug/min
—
6
46
8
32
2.53
1.60
1.1
1.1
—
—
u/ml
—
0
0
8
33
2.46
1.54
4.3
3.0
0.63
0.76
index
—
8
33
16
86
1.90
1.53
2.6
2.0
—
—
—
0
0
5
15
3.36
1.53
2.4
2.3
31.58
84.75
ug/l
—
5
15
95
772
1.31
1.45
4.3
2.7
—
—
—
0
0
17
96
1.81
1.41
3.6
3.5
9.58
2.19
index
0.99
12
58
10
47
2.16
1.35
1.6
1.2
—
—
—
0
0
32
218
1.51
1.34
13.7
5.0
0.65
0.63
%
0.13
32
218
15
84
1.82
1.29
2.7
2.0
349.40
217.05
u/ml
—
5
37
5
18
2.80
1.29
1.2
1.4
—
—
—
0
0
44
326
1.40
1.21
18.6
7.9
—
—
—
0
0
19
119
1.63
1.14
1.8
1.4
0.74
0.29
mg/l
—
8
50
8
40
2.02
1.12
2.8
4.7
—
—
—
0
0
23
336
0.66
1.11
4.1
5.2
35.13
32.27
%
0.66
15
211
43
328
1.35
1.02
3.5
4.1
7.27
41.76
ug/l
0.81
37
275
5
23
2.19
0.98
2.8
5.5
1.10
0.65
%
—
5
23
11
184
0.58
0.95
2.9
4.2
1.02
1.02
ratio
0.19
11
173
271
2565
1.24
0.94
5.1
5.2
4.28
4.44
mmol/l
1.80
228
2359
6
27
2.24
0.94
5.3
2.9
1057.67
639.63
mg
—
6
27
6
29
2.09
0.89
1.7
2.3
—
—
—
0
0
6
31
1.95
0.84
2.0
1.5
—
—
—
0
0
48
590
0.78
0.82
3.1
3.9
2.47
2.29
e6/l
0.06
25
315
86
741
1.21
0.79
4.2
3.2
341.99
350.37
umol/l
0.22
72
635
51
615
0.80
0.75
1.9
1.8
—
—
—
0
0
5
25
2.01
0.73
2.6
1.1
—
—
—
0
0
5
25
2.01
0.73
2.6
1.1
—
—
—
0
0
5
25
2.01
0.73
1.8
1.2
103.00
102.28
pmol/l
—
5
25
59
495
1.23
0.71
1.2
1.3
77.49
34.16
iu/ml
0.52
17
143
17
120
1.44
0.65
1.5
1.5
3.80
6.06
iu/ml
—
5
28
254
2422
1.17
0.65
4.6
4.4
1.17
1.22
mmol/l
0.52
203
2185
15
209
0.71
0.61
1.1
1.0
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
21
271
0.76
0.55
2.2
2.2
—
—
—
0
0
15
108
1.41
0.54
1.3
1.3
—
—
—
0
0
31
378
0.80
0.52
1.4
1.5
—
—
—
0
0
265
2553
1.15
0.52
5.0
5.1
1.51
1.46
mmol/l
0.78
223
2324
24
295
0.80
0.44
2.1
2.3
—
—
—
0
0
16
122
1.33
0.43
6.8
3.4
165.88
194.00
%
0.80
16
117
91
830
1.13
0.42
5.5
6.0
2.59
2.29
ug/l
0.28
74
728
12
87
1.39
0.42
1.4
1.4
—
—
—
0
0
12
87
1.39
0.42
1.4
1.4
—
—
—
0
0
8
58
1.39
0.42
1.8
1.4
—
—
—
0
0
271
2629
1.13
0.41
5.4
5.9
2.33
2.56
mmol/l
4.28
229
2404
5
33
1.52
0.41
1.4
1.6
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
0
17
0.00
0.40
0.0
1.8
—
8.34
—
0
17
5
34
1.48
0.40
1.4
1.6
—
—
—
0
0
5
34
1.48
0.40
1.4
1.6
—
—
—
0
0
70
633
1.13
0.38
5.7
4.4
263.39
287.44
ng/l
0.06
58
515
19
152
1.26
0.37
10.7
4.4
1.88
1.46
%
0.51
14
140
14
107
1.32
0.37
1.4
1.1
—
4.20
—
0
5
50
442
1.15
0.37
1.3
1.3
1.39
9.79
u/ml
2.83
17
161
14
179
0.77
0.36
1.9
2.2
—
—
—
0
0
112
1047
1.10
0.34
3.4
3.7
7.31
7.35
mmol/l
0.03
75
879
6
86
0.69
0.33
1.5
1.9
—
—
—
0
0
10
132
0.75
0.32
2.9
3.3
15.00
1709.36
u/ml
—
5
112
24
202
1.20
0.32
1.5
2.3
10.10
12.77
nmol/l
0.63
15
178
14
111
1.27
0.30
1.8
1.4
—
0.05
—
0
25
22
185
1.20
0.30
1.3
1.3
38.50
129.57
u/ml
—
9
59
15
121
1.25
0.29
1.3
1.9
1.00
0.49
g/l
—
5
107
12
151
0.79
0.29
1.4
1.3
—
—
—
0
0
58
630
0.90
0.26
3.1
3.5
1.27
1.04
e6/l
0.38
35
356
0
10
0.00
0.21
0.0
10.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
26.22
—
0
12
0
12
0.00
0.21
0.0
1.2
—
424.50
—
0
6
0
13
0.00
0.21
0.0
1.2
—
87.67
—
0
6
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
13
0.00
0.21
0.0
1.2
—
123.38
—
0
13
0
13
0.00
0.21
0.0
2.0
—
13.67
—
0
13
0
13
0.00
0.21
0.0
1.7
—
—
—
0
0
6
48
1.25
0.20
1.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
103.43
—
0
7
6
50
1.20
0.20
1.2
1.2
—
1.37
u/ml
—
0
19
7
58
1.21
0.18
1.4
1.5
—
—
—
0
0
7
59
1.19
0.18
1.4
1.7
—
—
—
0
0
13
152
0.85
0.17
1.3
2.1
—
—
—
0
0
17
148
1.16
0.17
1.8
2.8
24.35
47.84
u/ml
1.47
17
143
9
107
0.84
0.13
1.6
1.1
—
—
—
0
0
9
107
0.84
0.13
1.6
1.1
—
—
—
0
0
93
963
0.95
0.12
5.3
4.1
21.43
26.87
mg/mmol
0.11
48
620
11
127
0.86
0.12
1.4
1.8
8.90
10.25
g/l
—
6
110
67
641
1.06
0.12
3.8
5.1
22.35
21.63
%
0.13
40
336
49
464
1.06
0.12
3.1
3.4
0.89
0.83
ug/l
0.17
35
314
14
130
1.08
0.04
1.4
1.8
2.57
3.09
g/l
—
9
114
10
91
1.10
0.04
1.3
1.4
—
—
—
0
0
109
1099
0.99
0.01
2.0
2.0
1.21
1.28
mmol/l
0.48
75
910
75
744
1.01
0.00
6.3
4.9
1.02
1.02
kg/l
1.30
58
508
14
137
1.02
0.00
1.4
1.8
3.96
4.20
g/l
—
9
121
14
137
1.02
0.00
1.4
1.8
7.66
7.41
g/l
—
9
121
14
136
1.03
0.00
1.4
1.8
3.46
3.79
g/l
—
9
121
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
5
52
0.96
-0.00
1.2
1.7
—
—
—
0
0
7
74
0.94
-0.00
1.1
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
259.20
—
0
5
5
52
0.96
-0.00
2.4
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.87
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_PROTMALMODMILD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_PROTMALMODMILD | 3.147 [2.18, 4.54] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.571 |
During the follow-up period (1.1.1998 — 31.12.2019), 470 out of 1454 females with E4_PROTMALMODMILD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_PROTMALMODMILD | 5.396 [3.07, 9.48] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 388 out of 1064 males with E4_PROTMALMODMILD died.
Mortality risk
Mortality risk for people of age
years, who have E4_PROTMALMODMILD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.371% | 1.062% |
| 5 | 2.039% | 5.903% |
| 10 | 5.263% | 14.741% |
| 15 | 9.564% | 25.784% |
| 20 | 16.165% | 39.597% |
Relationships between endpoints
↥Index endpoint: E4_PROTMALMODMILD – Protein-energy malnutrition of moderate and mild degree
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data