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Disorders of pituitary gland, other and/or unspecified

DOID EFO Endpoint Browser PheWeb

E4_PITUDISNAS

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519870

1. Apply sex-specific rule

None

519870

2. Check conditions

None

519870

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E23.6, E23.7
  • Hospital discharge: ICD-9 — 253[8-9]
  • Hospital discharge: ICD-8 — 2539
  • Hospital discharge: excluded ICD-8 — 25390
  • Cause of death: ICD-10 — E23.6, E23.7
  • Cause of death: ICD-9 — 253[8-9]
  • Cause of death: ICD-8 — 2539
  • Cause of death: excluded ICD-8 — 25390

2 out of 7 registries used, show all original rules.

221

4. Check minimum number of events

None

221

5. Include endpoints

None

221

6. Filter based on genotype QC (FinnGen only)

214

Control definitions (FinnGen only)

Control exclude
E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1524 908 598
Only index persons 1235 751 484
Unadjusted period prevalence (%)
Whole population 0.02 0.03 0.02
Only index persons 0.02 0.03 0.02
Median age at first event (years)
Whole population 43.56 42.80 44.54
Only index persons 39.94 38.95 41.48

-FinnGen-

Key figures

All Female Male
Number of individuals 214 132 82
Unadjusted period prevalence (%) 0.04 0.05 0.04
Median age at first event (years) 43.19 40.98 46.75

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
221
Matched controls
2210
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H02AB09
ATC
hydrocortisone; systemic
106.0
154.0
81
12
E23.6
ICD-10 Finland
Other disorders of pituitary gland
+∞
124.0
107
*
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
63.7
58
*
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
+∞
61.4
56
*
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
57.9
53
*
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
363.7
57.1
55
*
E23.7
ICD-10 Finland
Disorder of pituitary gland, unspecified
+∞
55.6
51
*
H03AA01
ATC
levothyroxine sodium; systemic
6.5
43.2
116
322
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
192.9
32.7
33
*
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
10.7
32.2
38
42
102
Kela drug reimbursment
Diabetes insipidus
+∞
31.0
29
*
25399
ICD-8 Finland
Diseases of pituitary gland, Other and unspecified
+∞
27.7
26
*
25398
ICD-8 Finland
Diseases of pituitary gland, Alii definiti
+∞
26.6
25
*
D44.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pituitary gland
+∞
25.5
24
*
E22.1
ICD-10 Finland
Hyperprolactinaemia
+∞
22.3
21
*
E23.2
ICD-10 Finland
Diabetes insipidus
+∞
21.2
20
*
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
21.0
21.1
31
17
AA4BG
NOMESCO Finland
MRI examination of sella turcica with high intensity magnet
218.8
19.9
20
*
E23.09
ICD-10 Finland
Pituitary insufficiency NOS
+∞
18.0
17
*
N04BC06
ATC
cabergoline; oral
103.5
17.9
19
*
H01AC01
ATC
somatropin; parenteral
+∞
16.9
16
*
301
Kela drug reimbursment
Growth hormone
+∞
13.7
13
*
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
12.1
13.4
24
22
G02CB01
ATC
bromocriptine; systemic
18.2
13.3
20
12
E23.05
ICD-10 Finland
Lack of TSH
+∞
12.6
12
*
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
+∞
12.6
12
*
XCK00
NOMESCO Finland
Perimetry
4.8
12.1
29
67
E23.03
ICD-10 Finland
Lack of ACTH
+∞
11.6
11
*
ZXC86
NOMESCO Finland
Use of endoscopic device
63.1
10.7
12
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.6
10.3
37
116
E23
ICD-10 Finland
Hypofunction and other disorders of pituitary gland
+∞
9.4
9
*
E23.08
ICD-10 Finland
Hypopituitarism
+∞
9.4
9
*
2538X
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Other disorders of the pituitary and other syndromes of diencephalohypophyseal origin[MORBUS HYPOPHYSEOS SEU HYPOTHALAMI ALIA]
+∞
9.4
9
*
E23.01
ICD-10 Finland
Isolated deficiency of growth hormone
+∞
9.4
9
*
E23.0
ICD-10 Finland
Hypopituitarism
+∞
8.4
8
*
AA4DG
NOMESCO Finland
Very extensive MRI examination of sella turcica with high intensity magnet
+∞
8.4
8
*
AA4CM
NOMESCO Finland
Extensive MRI examination of sella turcica with 3 Tesla magnet
+∞
8.4
8
*
25320
ICD-8 Finland
Diseases of pituitary gland, Chromophobe adenoma, pituitary
+∞
8.4
8
*
E23.06
ICD-10 Finland
Empty sella
+∞
8.4
8
*
2532A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Panhypopituitarism[PANHYPOPITUITARISMUS]
+∞
8.4
8
*
121
Kela drug reimbursment
Severe hypofunction of sexual glands
10.0
7.9
15
16
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
4.5
7.6
19
45
E23.04
ICD-10 Finland
Hypogonadotropic hypogonadism
26.0
7.6
10
*
104
Kela drug reimbursment
Thyroid insufficiency
3.6
7.5
26
79
G02CB03
ATC
cabergoline; oral
82.8
7.5
8
*
22620
ICD-8 Finland
Benign neoplasm of endocrine glands, Pituitary gland and craniopharyngeal duct (pouch)
+∞
7.3
7
*
D35.31
ICD-10 Finland
Cyst in Rathke's pocket
+∞
7.3
7
*
2539X
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Unspecified
+∞
7.3
7
*
N91.1
ICD-10 Finland
Secondary amenorrhoea
23.3
6.7
9
*
D35.30
ICD-10 Finland
Craniopharyngoma
+∞
6.3
6
*
E22.0
ICD-10 Finland
Acromegaly and pituitary gigantism
+∞
6.3
6
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
6.2
113
754
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
6.0
74
426

TimeCodeWAS

↥

TODO / Current known limitations:

  • Only showing the top 500 codes, because showing all (sometimes 20k) makes the page too slow.
  • Legend / how to read the glyphs.
  • Proper column names.
  • Show details (e.g. Fisher or Chi-square test, N cases and N controls) when clicking on a row.
  • Explanation on the underlying data / how the TimeCodeWAS is done (e.g. matched cases / controls, eligibility).
  • Download CSV not working.
  • No filters and sorters.
  • Limited amount of endpoints with TimeCodeWAS data.
  • Cross-links to Risteys lab test pages for lab test codes.
OMOP Concept
ln(OR) -5y
ln(OR) -1y
ln(OR) -1m
ln(OR) d0
ln(OR) +1m
ln(OR) +1y
ln(OR) +5y
MCC -5y
MCC -1y
MCC -1m
MCC d0
MCC +1m
MCC +1y
MCC +5y
Panhypopituitarism
E23.00 (2000501468)
Benign neoplasm: Pituitary gland
D35.2 (45581304)
Extensive MRI examination of sella turcica with high intensity magnet
AA4CG (2001300145)
desmopressin; nasal, oral, parenteral, sublingual
H01BA02 (21602700)
Neoplasm of uncertain or unknown behaviour: Pituitary gland
D44.3 (45595760)
Diabetes insipidus
E23.2 (45600651)
Insulin-like growth factor-I [Moles/volume] in Serum or Plasma
29775-4 (3014326)
Disorder of pituitary gland, unspecified
E23.7 (45547643)
Other disorders of pituitary gland
E23.6 (45557119)
Transsphenoidal total or partial excision of intracranial lesion
AAE10 (2001300284)
Anterior pituitary hypofunction
101 (2001600101)
Hypopituitarism
E23.0 (45561963)
cabergoline; oral
G02CB03 (21602460)
cabergoline; oral
N04BC06 (21604478)
Body height measure
50373000 (4177340)
Body mass index
60621009 (4245997)
Prolactin [Units/volume] in Serum or Plasma
15081-3 (3021387)
Cortisol [Moles/volume] in Serum or Plasma
14675-3 (3036481)
Neurology
13 (38004458)
Neurosurgery
14 (38004459)
Obstetrics / Gynecology
16 (38004461)
Endocrinology
46 (38004485)
Inpatient Hospital
21 (8717)
Inpatient Visit
IP (9201)
Emergency Room Visit
ER (9203)
hydrocortisone; oral, parenteral
H02AB09 (21602737)
Outpatient Visit
OP (9202)
levothyroxine sodium; oral, parenteral
H03AA01 (21602754)
Testosterone [Moles/volume] in Serum or Plasma
14913-8 (3017446)
Thyroxine (T4) free [Moles/volume] in Serum or Plasma
14920-3 (3008486)
Internal Medicine
11 (38004456)
testosterone; oral, parenteral, rectal, sublingual, transdermal
G03BA03 (21602510)
Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method
4537-7 (3013707)
Case Management Agency
251B00000X (38004193)
Ophthalmology
18 (38004463)
Sodium [Moles/volume] in Serum or Plasma
2951-2 (3019550)
Potassium [Moles/volume] in Serum or Plasma
2823-3 (3023103)
MCHC [Entitic Mass/volume] in Red Blood Cells
28540-3 (3003338)
Erythrocyte [DistWidth] in Red Blood Cells
30385-9 (3002385)
Creatinine [Moles/volume] in Serum or Plasma
14682-9 (3020564)
MCH [Entitic mass]
28539-5 (3035941)
Platelets [#/volume] in Blood
26515-7 (3007461)
Hematocrit [Volume Fraction] of Blood by calculation
20570-8 (3009542)
Erythrocytes [#/volume] in Blood
26453-1 (3026361)
MCV [Entitic mean volume] in Red Blood Cells
30428-7 (3024731)
Supplier / Service Provider
OMOP5117446 (33004)
Leukocytes [#/volume] in Blood
26464-8 (3010813)
Hemoglobin [Mass/volume] in Blood
718-7 (3000963)

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
88
63
22.55
102.41
4.4
1.2
330.32
285.63
mu/l
0.51
83
58
46
55
10.30
37.01
2.3
1.2
4.90
7.82
u/l
1.15
36
44
57
109
6.70
30.29
2.9
3.3
4.15
4.57
pmol/l
1.77
50
98
44
94
5.60
20.42
2.1
1.2
23.42
26.92
iu/l
0.26
30
81
149
955
2.72
11.04
7.1
6.3
29.80
27.96
%
1.18
144
906
20
37
5.84
10.61
3.3
1.3
0.79
0.48
g/l
0.71
15
32
41
141
3.34
9.87
5.7
3.2
1.21
1.23
mmol/l
0.75
36
124
144
937
2.54
9.87
7.2
6.2
2.60
2.83
%
0.68
137
876
20
24
9.05
9.80
2.5
1.2
0.31
0.18
nmol/l
0.71
12
18
144
939
2.53
9.79
7.2
6.3
9.04
8.68
%
0.46
139
879
105
599
2.43
9.52
5.2
3.6
7.40
7.40
ph
0.02
84
420
142
939
2.43
9.08
7.3
6.3
0.70
0.68
%
0.13
137
873
153
1048
2.49
9.01
6.7
6.3
1.94
1.96
e9/l
0.04
134
922
142
945
2.41
8.86
13.9
7.0
1.21
1.21
mmol/l
0.45
117
811
133
866
2.35
8.64
13.0
6.2
1.21
1.21
mmol/l
0.13
127
804
73
367
2.48
8.59
4.4
2.8
477.05
516.25
mosm/kgh2o
0.89
60
321
109
654
2.32
8.57
6.2
5.8
—
—
—
0
0
149
1032
2.36
8.20
6.7
6.2
0.04
0.04
e9/l
0.06
127
881
43
170
2.90
8.11
4.4
5.0
1.11
1.02
%
0.07
18
45
41
158
2.96
8.09
4.4
4.9
0.50
0.63
%
0.17
16
39
131
863
2.27
8.07
7.7
4.7
35.37
36.08
g/l
0.75
124
813
41
159
2.94
8.00
4.5
5.1
0.13
0.18
%
0.18
16
34
148
1030
2.32
7.93
6.7
6.2
0.59
0.56
e9/l
0.72
127
881
150
1063
2.28
7.51
6.8
6.4
0.18
0.19
e9/l
0.41
128
932
38
147
2.91
7.43
5.0
4.0
—
—
—
0
0
18
42
4.58
7.36
1.4
1.3
—
—
—
0
0
61
303
2.40
7.22
3.1
2.2
2.21
2.32
g/l
0.81
55
281
41
169
2.75
7.12
4.6
5.4
0.00
0.16
%
0.80
15
37
13
14
9.78
6.88
1.4
1.2
0.46
0.47
ratio
—
6
7
155
1134
2.23
6.88
10.3
9.9
3.94
4.03
e9/l
0.21
136
988
128
882
2.07
6.49
19.4
11.3
0.00
0.00
e9/l
0.25
104
708
126
865
2.06
6.43
10.0
12.6
1.13
1.23
inr
1.80
106
722
19
53
3.83
6.19
1.3
1.3
58.33
5.67
e6/l
0.43
12
42
19
53
3.83
6.19
1.5
1.4
8.69
20.64
e6/l
0.63
13
42
13
21
6.50
5.47
2.7
2.5
33.08
31.81
pg
0.31
13
21
77
479
1.93
4.89
6.4
5.1
—
—
—
0
0
180
1480
2.17
4.84
9.3
4.3
15.08
14.78
pmol/l
0.76
175
1362
11
17
6.75
4.83
1.5
1.2
—
—
nmol/l
—
0
0
35
163
2.36
4.68
1.5
1.3
—
—
—
0
0
14
31
4.75
4.64
6.0
1.8
89.86
88.61
%
0.23
14
31
15
37
4.27
4.50
3.5
1.9
15.61
16.04
%
0.19
15
37
80
519
1.85
4.38
7.8
4.5
—
—
—
0
0
83
545
1.84
4.38
4.5
3.1
0.32
0.43
e6/l
0.39
64
393
12
26
4.82
4.12
6.2
1.6
5.69
6.07
pmol/l
0.13
12
26
10
18
5.76
4.02
1.4
1.0
—
—
—
0
0
48
271
1.99
3.96
1.3
1.3
—
—
—
0
0
14
39
3.76
3.77
11.7
1.8
—
—
—
0
0
28
131
2.30
3.71
2.3
2.4
—
7.28
—
0
6
9
16
5.81
3.70
1.2
1.3
108.56
105.50
pmol/l
—
9
16
14
40
3.67
3.68
11.7
1.9
8.26
7.99
kpa
0.20
14
40
39
210
2.04
3.65
20.9
10.2
7.42
7.42
ph
0.00
22
125
91
642
1.71
3.61
4.4
3.2
24.50
132.18
e6/l
0.53
71
484
10
21
4.93
3.60
3.4
2.5
0.85
0.87
%
—
10
15
60
380
1.79
3.45
1.9
1.7
492.60
36562950.58
pmol/l
0.50
55
320
65
426
1.74
3.32
3.9
2.5
5.00
5.10
e6/l
0.03
59
391
6
7
8.77
3.28
2.7
4.6
79.50
60.14
nmol/l
—
6
7
72
488
1.71
3.25
1.4
1.3
0.96
1.24
u/ml
0.36
20
131
10
24
4.31
3.23
1.5
1.5
—
—
—
0
0
99
733
1.64
3.17
4.9
4.0
18.97
94.48
e6/l
1.24
77
507
44
261
1.86
3.11
2.2
2.4
107.98
109.30
ug/g
0.02
34
208
39
225
1.89
3.00
1.2
1.4
—
—
—
0
0
5
5
10.19
2.99
1.4
3.2
2390.00
2459.00
ml
—
5
5
111
856
1.60
2.95
2.1
2.1
100.64
98.50
pmol/l
0.20
57
427
9
22
4.22
2.91
4.0
1.4
—
—
—
0
0
31
168
1.98
2.85
3.5
2.6
73.92
70.72
e9/l
0.15
23
118
19
86
2.32
2.72
2.6
1.9
—
—
—
0
0
9
24
3.86
2.70
2.7
1.5
86.59
89.57
%
—
9
24
9
24
3.86
2.70
5.0
3.6
0.67
1.29
%
—
9
19
65
448
1.64
2.70
1.5
1.8
0.83
1.21
mg/l
1.27
47
351
37
219
1.83
2.63
2.4
1.7
—
—
—
0
0
46
294
1.71
2.52
1.4
1.4
260.00
478.87
titre
—
8
71
194
1750
1.89
2.51
8.5
5.4
1.43
1.94
mu/l
7.30
185
1622
7
16
4.48
2.49
1.3
1.1
—
—
—
0
0
15
64
2.44
2.44
2.0
1.7
19.13
6.09
u/ml
—
7
11
8
22
3.73
2.38
2.1
3.0
—
—
—
0
0
5
8
6.36
2.38
1.2
1.1
149.60
144.08
mmol/24h
—
5
8
79
587
1.54
2.35
5.3
3.2
0.00
0.01
estimate
0.50
32
175
43
276
1.69
2.32
3.0
2.2
—
—
—
0
0
112
899
1.50
2.30
3.3
2.7
—
—
estimate
—
0
0
13
54
2.50
2.24
3.7
1.8
24.99
24.60
mmol/l
0.18
13
54
89
684
1.50
2.24
4.5
3.4
2.32
2.35
mmol/l
1.64
84
619
10
35
2.94
2.24
8.0
3.0
4.10
4.83
e9/l
—
10
35
75
556
1.53
2.24
5.5
3.2
—
—
—
0
0
88
675
1.50
2.23
3.3
3.2
7.63
7.64
mmol/l
0.00
80
574
82
620
1.51
2.23
3.0
3.3
14.76
51.41
mg/l
3.99
55
383
32
191
1.79
2.22
23.4
10.5
94.76
96.05
%
0.62
32
186
102
810
1.48
2.17
5.9
3.6
0.03
0.00
estimate
0.49
36
178
83
636
1.49
2.09
4.1
4.0
1.56
8.94
mg/mmol
5.00
55
387
6
15
4.08
2.05
1.0
1.1
—
—
—
0
0
67
497
1.50
1.96
2.1
2.6
351.96
339.76
umol/l
0.41
55
430
11
45
2.52
1.96
9.6
3.1
48.45
60.16
%
0.89
11
45
8
27
3.03
1.95
1.1
1.1
—
—
—
0
0
60
439
1.50
1.87
1.5
1.3
2.56
2.48
g/l
0.14
41
247
44
303
1.56
1.80
1.8
1.6
1324.69
1155.48
nmol/l
0.53
35
221
195
1801
1.70
1.79
7.5
6.2
39.54
39.30
mmol/mol
0.14
189
1704
96
775
1.42
1.79
2.2
2.0
—
—
—
0
0
45
313
1.55
1.76
3.5
3.2
3.09
2.56
e6/l
0.15
23
151
25
150
1.75
1.72
1.4
1.5
—
—
—
0
0
47
336
1.51
1.63
2.2
1.9
—
—
—
0
0
19
107
1.85
1.60
1.3
1.2
—
—
—
0
0
79
626
1.41
1.60
2.6
2.2
—
—
—
0
0
8
33
2.48
1.55
1.4
1.2
—
—
—
0
0
11
51
2.22
1.53
4.8
3.0
1.83
2.87
index
—
6
31
5
15
3.38
1.53
1.2
1.3
2.52
3.38
mg/l
—
5
15
7
27
2.64
1.52
1.7
2.0
—
—
—
0
0
122
1048
1.37
1.49
5.8
3.8
0.00
0.00
estimate
-0.00
41
212
21
126
1.74
1.46
1.2
1.2
—
—
—
0
0
23
142
1.69
1.45
1.2
1.2
141.03
149.93
u/ml
—
9
55
25
158
1.66
1.45
2.0
2.2
63.52
67.39
g/l
1.14
25
147
38
267
1.51
1.43
9.4
6.5
104.89
104.12
mmol/l
0.34
38
267
123
1063
1.35
1.42
5.8
3.8
0.00
7.45
estimate
0.50
41
218
12
61
2.02
1.35
1.2
1.2
—
—
—
0
0
122
1064
1.33
1.27
5.7
3.9
0.00
0.00
estimate
-0.00
42
196
16
93
1.78
1.25
2.5
2.2
—
—
—
0
0
33
232
1.50
1.24
1.5
1.6
—
—
—
0
0
20
125
1.66
1.22
1.2
1.3
87.98
241.99
u/ml
1.21
20
114
15
86
1.80
1.22
1.1
1.2
—
—
—
0
0
5
19
2.67
1.22
3.2
3.5
4.80
3.35
nmol/l
—
5
19
30
210
1.50
1.16
6.6
3.6
7.38
7.39
ph
0.40
15
119
50
386
1.38
1.16
3.9
3.7
47.68
280.87
ng/l
1.70
37
296
89
751
1.31
1.14
5.6
3.5
25.68
37.54
ng/l
0.96
65
519
39
290
1.42
1.12
1.8
1.6
—
—
—
0
0
12
66
1.87
1.11
10.4
2.4
1.41
1.42
mg/l
0.01
12
57
5
21
2.41
1.09
1.0
1.2
—
—
—
0
0
34
251
1.42
1.02
2.5
2.7
5.60
6.71
umol/l
0.38
27
227
24
165
1.51
1.02
14.3
8.0
—
—
—
0
0
71
590
1.30
1.01
5.4
3.8
0.00
0.00
estimate
-0.00
37
198
20
134
1.54
0.95
1.7
1.5
1.11
1.39
g/l
0.49
20
125
24
168
1.48
0.94
1.5
1.9
—
—
—
0
0
6
29
2.10
0.90
2.7
2.3
—
—
—
0
0
71
602
1.26
0.85
8.0
6.7
—
—
—
0
0
97
855
1.24
0.82
4.4
3.3
6.15
6.16
ph
0.03
66
494
11
68
1.65
0.73
9.5
3.3
—
—
—
0
0
7
40
1.77
0.72
1.4
1.6
—
—
—
0
0
33
261
1.31
0.67
2.2
1.5
—
—
—
0
0
11
70
1.60
0.66
4.1
1.6
1.02
5.02
ug/l
0.48
11
60
17
121
1.44
0.64
4.9
3.3
24.88
24.65
mmol/l
0.10
17
121
198
1911
1.35
0.64
26.7
15.5
24.89
22.49
mg/l
0.39
178
1562
26
203
1.32
0.59
2.0
2.6
23.00
30.36
u/l
1.50
17
170
187
1798
1.26
0.57
4.9
4.2
1.43
1.28
mmol/l
1.94
178
1662
18
135
1.36
0.53
1.4
2.0
—
—
—
0
0
26
208
1.28
0.51
6.2
3.4
5.90
5.74
kpa
0.27
26
203
190
1836
1.25
0.50
5.8
5.0
5.82
5.93
mmol/l
0.56
182
1706
15
110
1.39
0.50
33.3
8.4
—
—
—
0
0
7
50
1.41
0.45
7.6
4.8
—
—
—
0
0
28
230
1.25
0.45
1.4
1.3
—
—
—
0
0
57
505
1.17
0.44
6.6
4.6
1.88
2.39
ug/l
0.31
52
449
5
31
1.63
0.43
1.0
1.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
17
0.00
0.41
0.0
16.5
—
795.00
—
0
17
5
34
1.48
0.40
1.2
1.2
—
—
—
0
0
86
791
1.14
0.40
4.1
3.1
—
—
—
0
0
14
106
1.34
0.40
5.1
3.5
1.02
1.02
ratio
0.25
14
101
0
18
0.00
0.40
0.0
2.8
—
—
—
0
0
42
366
1.18
0.39
1.4
1.3
1.63
7.87
u/ml
2.60
17
154
11
80
1.39
0.39
2.0
1.3
—
—
—
0
0
144
1372
1.14
0.39
4.4
3.2
62.76
46.41
u/l
0.57
136
1304
5
36
1.40
0.38
2.8
1.7
4.08
111.74
u/ml
—
5
36
23
189
1.24
0.38
1.2
1.2
—
—
—
0
0
5
37
1.36
0.37
1.0
1.0
—
—
—
0
0
5
76
0.65
0.36
1.2
1.1
0.89
0.89
g/l
—
5
76
44
388
1.17
0.36
1.5
1.3
17.76
29.03
iu/ml
1.05
11
122
6
43
1.41
0.35
1.0
1.3
—
—
—
0
0
6
45
1.34
0.34
1.0
1.1
—
—
—
0
0
6
45
1.34
0.34
1.0
1.1
—
—
—
0
0
7
52
1.36
0.31
67.3
14.6
1.06
1.22
mmol/l
—
7
45
15
120
1.27
0.31
33.9
10.6
24.08
24.46
mmol/l
0.22
15
115
11
84
1.33
0.30
2.0
1.3
—
—
—
0
0
11
84
1.33
0.30
2.0
1.3
—
—
—
0
0
7
55
1.28
0.30
9.6
2.9
69.94
57.31
%
—
7
55
8
66
1.22
0.27
1.3
1.1
—
—
—
0
0
12
95
1.28
0.27
1.7
1.8
—
—
—
0
0
5
75
0.66
0.26
1.0
1.1
1.57
1.57
g/l
—
5
75
195
1914
1.16
0.25
6.4
5.8
2.65
2.73
mmol/l
0.62
188
1790
23
199
1.17
0.24
5.1
4.4
203.82
8.30
ug/l
0.46
16
163
52
480
1.11
0.23
5.3
3.6
1.02
1.02
kg/l
0.56
36
312
24
210
1.16
0.23
1.5
1.5
—
—
—
0
0
208
2055
1.21
0.21
39.3
23.4
257.74
252.54
e9/l
0.38
201
2026
57
532
1.10
0.20
1.5
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
6.4
—
8.70
—
0
14
208
2056
1.20
0.19
39.2
23.4
6.85
6.64
e9/l
0.75
201
2016
208
2056
1.20
0.19
39.1
23.3
4.46
4.51
e12/l
0.72
201
2015
89
849
1.08
0.19
2.2
2.0
1.54
1.37
mmol/l
1.02
76
736
192
1889
1.13
0.19
5.8
5.1
4.60
4.67
mmol/l
0.50
184
1770
7
58
1.21
0.18
1.9
1.3
—
—
—
0
0
5
67
0.74
0.17
3.2
12.7
—
—
—
0
0
5
70
0.71
0.17
2.0
2.4
—
—
—
0
0
9
81
1.12
0.15
2.2
1.3
—
—
—
0
0
10
84
1.20
0.14
2.1
1.3
—
—
—
0
0
21
190
1.12
0.13
1.9
2.1
0.00
0.00
estimate
—
7
36
190
1878
1.08
0.12
5.7
5.0
1.42
1.48
mmol/l
1.28
183
1752
10
87
1.16
0.09
1.0
1.1
—
—
—
0
0
24
223
1.09
0.09
1.3
1.5
—
—
—
0
0
8
78
1.03
0.07
60.6
11.0
0.64
0.85
%
—
8
72
13
120
1.09
0.05
1.0
1.1
—
—
—
0
0
31
299
1.04
0.04
3.6
2.8
0.93
0.66
ug/l
0.59
22
175
13
123
1.06
0.01
3.5
2.4
1.47
1.25
%
0.42
13
123
12
121
0.99
0.00
2.7
2.4
0.72
0.63
%
0.27
12
121
10
97
1.03
0.00
1.5
2.1
0.00
0.00
estimate
—
5
32
18
185
0.97
0.00
2.7
2.6
5.92
6.18
ph
0.91
12
120
195
1948
1.01
0.00
26.7
13.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
1.70
—
0
6
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
0.02
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
5.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
87
0.92
-0.00
59.9
10.0
1.24
1.57
%
—
8
81
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
2.20
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
6
61
0.98
-0.00
1.3
1.2
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint E4_PITUDISNAS and mortality.

Females

Parameter HR [95% CI] p-value
E4_PITUDISNAS 2.384 [1.81, 3.14] < 0.001
Birth year 0.992 [0.98, 1.0] 0.063

During the follow-up period (1.1.1998 — 31.12.2019), 84 out of 396 females with E4_PITUDISNAS died.

Males

Parameter HR [95% CI] p-value
E4_PITUDISNAS 1.387 [0.99, 1.95] 0.06
Birth year 0.989 [0.98, 1.0] 0.015

During the follow-up period (1.1.1998 — 31.12.2019), 55 out of 288 males with E4_PITUDISNAS died.

Mortality risk

Mortality risk for people of age

years, who have E4_PITUDISNAS.

N-year risk Females Males
1 0.202% 0.217%
5 1.248% 1.664%
10 3.13% 4.363%
15 5.77% 8.112%
20 10.357% 13.946%

Relationships between endpoints

↥

Index endpoint: E4_PITUDISNAS – Disorders of pituitary gland, other and/or unspecified

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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