parathyroid disease: A disease involving the parathyroid gland.
Disorders of parathyroid gland, other and/or unspecified
DOID EFO Endpoint Browser PheWeb
E4_PARANAS
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
278 |
4. Check minimum number of eventsNone |
278 |
5. Include endpointsNone |
278 |
6. Filter based on genotype QC (FinnGen only) |
251 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Disorders of parathyroid gland, other and/or unspecified
based on the number of shared cases.
Similar with more cases:
- Disorders of parathyroid gland
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any operation in hilmo
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1856 | 1425 | 415 |
| Only index persons | 1503 | 1173 | 330 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.01 |
| Only index persons | 0.04 | 0.04 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 64.79 | 65.50 | 62.14 |
| Only index persons | 63.64 | 64.58 | 60.30 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 251 | 196 | 55 |
| Unadjusted period prevalence (%) | 0.06 | 0.07 | 0.03 |
| Median age at first event (years) | 60.46 | 60.78 | 59.33 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 257
- Matched controls
- 2570
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E21.5
ICD-10 Finland
Disorder of parathyroid gland, unspecified
+∞
207.5
170
*
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
+∞
160.9
137
*
BBA30
NOMESCO Finland
Excision of lesion of parathyroid gland
+∞
72.4
66
*
E21.3
ICD-10 Finland
Hyperparathyroidism, unspecified
216.2
65.4
65
*
E21.4
ICD-10 Finland
Other specified disorders of parathyroid gland
+∞
64.3
59
*
BBA40
NOMESCO Finland
Subtotal parathyroidectomy
724.2
60.3
57
*
A11CC03
ATC
alfacalcidol; systemic
23.1
60.3
46
24
E21.0
ICD-10 Finland
Primary hyperparathyroidism
190.3
58.7
59
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
7.3
37.7
65
114
E21.2
ICD-10 Finland
Other hyperparathyroidism
+∞
34.1
32
*
E83.50
ICD-10 Finland
Hypercalcemia
44.0
33.6
41
11
H05BX01
ATC
cinacalcet; oral
+∞
30.9
29
*
E21
ICD-10 Finland
Hyperparathyroidism and other disorders of parathyroid gland
+∞
28.7
27
*
106
Kela drug reimbursment
Hypoparathyroidism
+∞
28.7
27
*
A12AA04
ATC
calcium carbonate; oral
38.9
27.3
34
10
321
Kela drug reimbursment
Paricalcitol and cinacalcet
275.7
25.1
25
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
5.9
24.1
49
99
A12AA06
ATC
calcium lactate gluconate; oral
+∞
19.0
18
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
5.6
19.0
39
79
BBA20
NOMESCO Finland
Exploration of parathyroid gland
+∞
16.9
16
*
M14.1*E21.5
ICD-10 Finland
Crystal arthropathy in hyperparathyroidism
+∞
14.7
14
*
A11CC02
ATC
dihydrotachysterol; oral
158.6
14.6
15
*
D35.1
ICD-10 Finland
Benign neoplasm: Parathyroid gland
158.6
14.6
15
*
E20.9
ICD-10 Finland
Hypoparathyroidism, unspecified
147.5
13.6
14
*
N18.8
ICD-10 Finland
Other chronic renal failure
11.4
13.6
25
24
205
Kela drug reimbursment
Chronic hypertension
2.7
13.3
109
550
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
14.0
13.2
22
17
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
6.1
12.7
23
41
196
Kela drug reimbursment
Paricalcitol and cinacalcet
+∞
11.5
11
*
N18.5
ICD-10 Finland
Chronic kidney disease, stage 5
36.8
11.4
14
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
12.7
11.0
19
16
Z49.1
ICD-10 Finland
Extracorporeal dialysis
22.6
10.8
15
7
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
62.7
10.7
12
*
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
114.5
10.5
11
*
25298
ICD-8 Finland
Diseases of parathyroid gland, Alii definiti
+∞
10.5
10
*
M04AA01
ATC
allopurinol; systemic
2.9
10.1
54
214
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
41.8
10.1
12
*
127
Kela drug reimbursment
Transplant complication
17.6
10.0
15
9
E83.51
ICD-10 Finland
Hypocalcemia
21.0
9.9
14
7
Z94.0
ICD-10 Finland
Kidney transplant status
21.0
9.9
14
7
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
+∞
9.4
9
*
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
25.1
9.0
12
5
TK800
NOMESCO Finland
Hemodialysis
13.2
9.0
15
12
C02AC05
ATC
moxonidine; oral
4.4
8.9
23
56
L04AA06
ATC
mycophenolic acid; systemic
11.3
8.9
16
15
C03CA01
ATC
furosemide; systemic
2.2
8.8
120
730
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.2
8.8
135
861
V03AE02
ATC
sevelamer; oral
51.8
8.7
10
*
C08CA01
ATC
amlodipine; oral
2.2
8.6
138
893
N18.0
ICD-10 Finland
End-stage renal disease
28.6
8.6
11
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.7
8.5
50
208
E21.1
ICD-10 Finland
Secondary hyperparathyroidism, not elsewhere classified
93.0
8.5
9
*
E20.8
ICD-10 Finland
Other hypoparathyroidism
+∞
8.4
8
*
BB1BQ
NOMESCO Finland
Extensive scintigraphy of parathyroid gland, 2 isotopes, SPECT and low-dose CT
+∞
8.4
8
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.2
8.4
103
598
Z49.0
ICD-10 Finland
Preparatory care for dialysis
22.9
8.1
11
5
M80.0
ICD-10 Finland
Postmenopausal osteoporosis with pathological fracture
4.7
8.0
19
43
WZC30
NOMESCO Finland
Teaching
2.5
8.0
60
281
D44.8
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pluriglandular involvement
46.4
7.8
9
*
M81.9
ICD-10 Finland
Osteoporosis, unspecified
3.3
7.5
30
100
Q61.2
ICD-10 Finland
Polycystic kidney, autosomal dominant
82.4
7.5
8
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.2
7.4
83
460
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
7.4
150
1039
A41.9
ICD-10 Finland
Sepsis, unspecified
4.5
7.3
18
42
25299
ICD-8 Finland
Diseases of parathyroid gland, Other and unspecified
+∞
7.3
7
*
E20.0
ICD-10 Finland
Idiopathic hypoparathyroidism
+∞
7.3
7
*
BBA70
NOMESCO Finland
Implantation or transplantation of parathyroid gland
+∞
7.3
7
*
UJF32
NOMESCO Finland
Coloscopy
2.1
7.3
91
527
B03XA02
ATC
darbepoetin alfa; parenteral
8.3
7.2
15
19
N06AA09
ATC
amitriptyline; systemic
2.7
7.0
40
163
R50.9
ICD-10 Finland
Fever, unspecified
2.4
7.0
52
242
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
7.0
6.9
16
24
M05BA04
ATC
alendronic acid; oral
2.5
6.8
46
204
B05DA
ATC
Isotonic solutions
17.3
6.8
10
6
M81.0
ICD-10 Finland
Postmenopausal osteoporosis
3.8
6.7
21
59
R07.4
ICD-10 Finland
Chest pain, unspecified
2.0
6.7
98
597
B05DB
ATC
Hypertonic solutions
23.2
6.7
9
*
M10.9
ICD-10 Finland
Gout, unspecified
3.3
6.7
26
85
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.1
6.5
81
464
M05BX04
ATC
denosumab; parenteral
2.9
6.5
32
120
C08CA13
ATC
lercanidipine; oral
2.2
6.5
61
313
137
Kela drug reimbursment
Uraemia requiring dialysis
14.8
6.4
10
7
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.1
6.4
77
435
N05AN01
ATC
lithium; oral
8.5
6.4
13
16
H03AA01
ATC
levothyroxine sodium; systemic
2.1
6.4
82
476
C07AB07
ATC
bisoprolol; oral
2.0
6.4
158
1151
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.7
6.3
35
140
UKC02
NOMESCO Finland
Cystoscopy
2.4
6.3
49
231
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
18.6
6.3
9
5
E26.0
ICD-10 Finland
Primary hyperaldosteronism
+∞
6.3
6
*
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
27.4
6.3
8
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.0
6.2
83
488
Z01.8
ICD-10 Finland
Other specified special examinations
2.1
6.1
68
373
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
121
213
9.85
73.84
6.4
2.8
116.72
77.58
ng/l
2.61
103
179
46
44
12.52
43.24
6.4
1.8
23.87
7.07
pmol/l
1.38
46
44
112
306
5.71
41.08
11.9
4.5
1.08
1.05
mmol/l
0.36
104
275
207
1301
4.04
19.05
21.3
6.5
1.26
1.21
mmol/l
6.85
179
1122
184
1116
3.28
17.00
5.2
2.4
81.06
81.58
nmol/l
0.09
178
987
187
1177
3.16
15.56
16.2
5.8
1.26
1.21
mmol/l
7.00
181
1084
60
216
3.32
13.48
13.0
3.9
1.24
1.23
mmol/l
0.21
55
184
86
423
2.55
10.62
6.0
2.2
11.84
12.49
umol/l
0.40
80
388
82
398
2.56
10.38
6.0
2.2
2.25
2.31
g/l
0.38
74
358
146
923
2.35
10.15
4.1
3.2
2.44
2.36
mmol/l
3.47
140
830
110
618
2.36
10.04
3.0
2.2
3.66
3.13
mg/l
0.73
96
533
78
380
2.51
9.72
6.2
2.2
20.92
21.47
%
0.15
72
351
164
1122
2.28
9.03
8.2
4.2
35.21
35.43
g/l
0.20
155
1045
30
91
3.60
8.65
1.8
3.6
1.09
3.21
ratio
1.68
14
54
31
97
3.50
8.53
1.9
4.0
35.86
48.21
mg/l
0.24
20
83
31
97
3.50
8.53
1.9
4.0
38.71
112.70
mg/l
0.64
20
84
181
1331
2.22
7.78
8.9
10.0
4.35
4.06
e9/l
1.02
159
1151
75
403
2.22
7.22
4.1
2.9
0.80
0.81
mmol/l
0.10
70
381
125
816
2.04
7.20
4.2
3.2
5.96
6.67
mmol/l
1.38
110
675
148
1027
2.04
7.18
5.6
2.8
198.26
117.77
ug/l
2.32
136
939
123
817
1.97
6.57
5.4
4.0
24.58
7.67
mg/mmol
1.21
88
475
56
281
2.27
6.29
5.0
3.6
—
—
—
0
0
97
602
1.98
6.24
4.4
2.8
365.26
338.94
umol/l
1.54
86
514
120
808
1.91
6.01
2.5
2.1
675.78
198.90
u/l
0.39
114
758
29
108
2.90
5.99
1.4
1.8
3.05
3.03
g/l
0.03
29
100
12
15
8.33
5.90
1.2
1.3
158.42
115.13
pmol/l
1.13
12
15
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
21
66
3.38
5.73
3.5
2.5
0.44
0.44
iu/ml
0.02
13
36
30
117
2.77
5.70
1.5
1.8
4.23
4.36
g/l
0.31
30
109
30
117
2.77
5.70
1.5
1.8
3.53
3.89
g/l
0.60
30
109
30
117
2.77
5.70
1.5
1.8
7.58
7.58
g/l
0.01
30
109
129
905
1.85
5.56
5.5
3.3
—
—
—
0
0
26
98
2.84
5.26
1.8
1.7
10.67
4.39
ug/l
0.28
21
89
12
20
6.24
4.97
1.4
1.6
124.58
87.14
ng/l
0.80
12
20
70
417
1.93
4.91
1.9
1.8
—
—
—
0
0
75
459
1.90
4.84
2.1
1.7
1296.79
1236.75
nmol/l
0.19
55
333
39
190
2.24
4.65
1.8
1.6
—
—
—
0
0
32
143
2.41
4.64
9.7
3.7
5.10
5.22
kpa
0.39
32
137
213
1804
2.06
4.60
12.4
8.1
85.79
80.64
u/l
0.81
208
1690
14
32
4.57
4.51
1.4
1.3
—
—
—
0
0
88
582
1.78
4.37
3.2
2.7
2.56
2.47
mmol/l
2.51
81
518
108
762
1.72
4.25
3.1
2.4
60.66
69.25
u/l
0.42
103
695
104
729
1.72
4.17
5.1
3.2
0.16
0.49
e6/l
2.96
83
516
14
36
4.05
4.06
1.3
1.3
—
—
—
0
0
108
780
1.66
3.79
1.9
1.7
20.07
22.21
nmol/l
0.76
93
639
131
997
1.64
3.73
5.8
4.1
29.84
31.92
ng/l
0.16
109
748
24
104
2.44
3.72
1.3
1.7
9.30
9.93
g/l
0.40
24
95
175
1434
1.69
3.72
6.9
4.7
7.09
6.65
mmol/l
1.68
175
1359
189
1585
1.73
3.64
6.8
5.3
—
5002.61
—
0
33
143
1118
1.63
3.61
2.4
2.2
107.13
100.42
pmol/l
0.54
66
527
7
9
7.96
3.58
3.6
6.6
—
—
—
0
0
162
1315
1.63
3.44
6.5
4.5
0.00
5.64
estimate
0.50
51
288
12
32
3.88
3.43
2.6
1.8
89.39
90.01
%
0.12
12
32
96
687
1.63
3.42
5.9
3.9
0.00
0.00
estimate
-0.00
46
218
161
1308
1.62
3.38
6.5
4.5
0.00
0.00
estimate
-0.00
49
277
53
323
1.81
3.38
1.8
1.8
—
—
—
0
0
77
525
1.67
3.30
1.9
1.8
694.32
477.71
pmol/l
0.49
66
421
6
7
8.74
3.28
2.0
1.1
37.48
68.67
ug/l
—
6
7
12
36
3.45
3.06
1.8
1.6
—
—
—
0
0
50
309
1.77
3.04
1.8
1.8
—
—
—
0
0
126
983
1.55
3.03
6.8
4.5
0.00
0.03
estimate
0.96
44
221
142
1138
1.55
3.02
2.6
2.7
—
—
—
0
0
161
1328
1.57
3.00
6.5
4.5
0.15
0.01
estimate
0.70
47
265
5
5
10.16
2.99
1.6
1.0
—
—
—
0
0
200
1742
1.67
2.92
6.7
4.6
16.14
13.77
mm/h
1.31
192
1596
101
760
1.54
2.80
7.1
4.5
0.00
0.01
estimate
0.50
48
258
5
6
8.47
2.76
1.2
1.0
—
—
—
0
0
202
1773
1.65
2.76
7.4
4.5
15.73
15.06
pmol/l
3.23
188
1594
45
279
1.74
2.70
7.4
2.8
5.54
5.78
kpa
0.84
45
272
77
550
1.57
2.67
2.0
1.6
2.03
1.29
mg/l
0.31
54
452
18
81
2.31
2.60
1.6
1.3
195.36
275.72
ug/g
—
8
52
6
11
5.55
2.56
1.0
1.5
97.97
9.05
u/l
—
6
11
66
462
1.58
2.48
1.5
1.3
18.83
38.84
iu/ml
2.19
26
148
108
845
1.48
2.41
4.3
3.2
2078.30
1477.97
ng/l
0.71
94
725
10
33
3.11
2.38
1.4
1.3
—
—
—
0
0
8
22
3.72
2.38
1.3
1.4
—
—
—
0
0
42
265
1.70
2.37
7.8
3.0
1.61
2.28
mmol/l
0.59
37
223
34
205
1.76
2.25
7.0
3.0
42.00
58.79
ml/min/173m2
1.63
20
77
15
67
2.32
2.22
1.5
1.4
—
—
—
0
0
68
493
1.52
2.17
4.9
4.1
46.62
180.40
ng/l
1.88
60
412
9
30
3.07
2.17
1.2
1.5
—
—
—
0
0
8
25
3.27
2.11
1.0
1.1
—
—
—
0
0
38
242
1.67
2.08
5.0
2.4
4.83
4.41
kpa
0.48
38
233
24
134
1.87
2.03
1.8
1.3
—
—
—
0
0
18
91
2.05
2.00
1.2
1.2
—
—
—
0
0
223
2054
1.65
1.98
8.7
5.8
1.90
1.99
mu/l
0.40
210
1871
5
11
4.61
1.95
5.2
2.8
824.00
77.64
nmol/l
—
5
11
14
65
2.22
1.92
1.4
1.2
—
—
—
0
0
12
52
2.37
1.90
1.7
1.6
—
—
—
0
0
38
249
1.62
1.87
3.3
2.4
8.13
7.47
umol/l
0.11
31
213
9
194
0.44
1.81
1.6
1.4
—
—
—
0
0
7
23
3.10
1.81
1.1
1.1
—
—
—
0
0
7
23
3.10
1.81
1.3
1.0
—
—
—
0
0
8
29
2.81
1.80
3.4
1.4
—
—
—
0
0
57
421
1.45
1.64
1.4
1.3
2.35
14.19
u/ml
2.71
20
152
5
14
3.62
1.62
5.4
5.8
—
42.18
u/ml
—
0
6
8
32
2.55
1.61
2.0
1.4
20.57
17.12
ug/l
—
8
32
69
531
1.41
1.59
1.4
1.3
1.83
1.52
u/ml
0.09
22
133
12
57
2.16
1.57
1.3
1.8
2.32
4.97
iu/l
—
6
23
21
124
1.76
1.52
4.3
3.0
23.26
25.05
mmol/l
0.83
21
124
9
41
2.24
1.38
1.3
1.6
—
—
—
0
0
5
17
2.98
1.36
1.0
1.2
—
—
—
0
0
5
17
2.98
1.36
1.2
4.1
2142.40
983.24
mg
—
5
17
54
410
1.40
1.34
4.4
3.0
5.03
3.10
e6/l
0.45
29
184
160
1760
0.76
1.31
32.3
23.1
328.25
330.35
g/l
2.13
160
1751
12
62
1.98
1.30
2.0
1.5
—
—
—
0
0
58
451
1.37
1.25
3.8
2.9
1.54
0.98
e6/l
0.40
32
223
9
45
2.04
1.24
1.9
1.3
0.91
0.93
g/l
—
9
45
14
78
1.84
1.23
1.5
1.3
—
1.22
—
0
5
5
19
2.66
1.22
1.6
1.1
—
—
—
0
0
5
20
2.53
1.15
3.6
2.5
—
—
—
0
0
229
2177
1.48
1.14
30.6
17.2
20.96
23.38
mg/l
0.81
203
1819
67
543
1.32
1.10
3.0
2.4
—
—
—
0
0
7
32
2.22
1.09
1.3
1.1
—
—
—
0
0
222
2104
1.40
1.07
9.3
6.8
41.33
39.76
mmol/mol
1.43
211
1954
22
147
1.54
1.04
1.2
1.2
113.76
209.23
u/ml
0.67
22
131
18
115
1.61
1.02
1.0
1.0
—
—
—
0
0
120
1056
1.26
1.02
3.3
2.7
—
—
estimate
—
0
0
5
23
2.20
0.98
1.0
1.1
—
—
—
0
0
14
85
1.68
0.96
2.4
1.7
—
—
—
0
0
6
28
2.17
0.92
1.0
1.1
—
—
—
0
0
8
43
1.89
0.88
1.8
1.9
—
—
—
0
0
8
43
1.89
0.88
1.6
1.3
1.52
1.63
g/l
—
8
43
11
65
1.72
0.83
1.6
1.3
—
1.03
—
0
6
8
46
1.76
0.83
1.3
1.4
—
—
—
0
0
12
73
1.68
0.83
1.6
1.4
—
1.75
—
0
14
12
73
1.68
0.83
1.6
1.4
—
7.24
—
0
18
13
81
1.64
0.83
3.0
2.1
—
—
—
0
0
8
47
1.72
0.81
1.3
1.3
—
—
—
0
0
19
131
1.49
0.81
1.3
1.4
—
36.78
—
0
10
11
66
1.70
0.80
1.3
1.6
—
—
—
0
0
8
48
1.69
0.79
1.1
1.5
—
—
—
0
0
12
75
1.63
0.76
3.1
2.0
—
—
—
0
0
9
54
1.69
0.75
1.1
1.5
—
—
—
0
0
9
55
1.66
0.74
1.8
1.8
—
—
—
0
0
5
25
2.02
0.73
1.6
1.9
—
—
—
0
0
7
41
1.73
0.70
2.1
1.2
26.80
19.81
u/l
—
7
36
151
1398
1.19
0.69
4.5
3.1
70.98
47.50
u/l
1.48
139
1299
12
78
1.56
0.67
1.2
1.6
—
—
—
0
0
21
278
0.73
0.64
7.0
7.8
—
—
—
0
0
38
308
1.27
0.64
6.2
7.3
5.01
5.14
kpa
0.35
38
297
38
308
1.27
0.64
6.2
7.3
11.14
11.85
kpa
0.49
38
297
0
20
0.00
0.60
0.0
1.8
—
—
—
0
0
0
21
0.00
0.60
0.0
1.8
—
—
—
0
0
10
64
1.59
0.59
1.4
1.6
—
—
—
0
0
12
81
1.51
0.58
1.8
2.7
—
—
—
0
0
6
38
1.59
0.54
1.0
1.7
—
—
—
0
0
20
152
1.34
0.54
1.8
1.6
—
—
—
0
0
7
45
1.57
0.49
1.0
1.7
—
—
—
0
0
8
56
1.44
0.43
2.8
1.1
—
—
—
0
0
8
57
1.42
0.42
1.4
1.4
—
—
—
0
0
10
71
1.42
0.40
5.0
3.7
1.00
1.75
index
—
5
40
15
116
1.31
0.38
5.5
3.8
1.22
1.54
%
1.16
15
109
106
990
1.12
0.37
2.2
2.0
1.41
1.29
mmol/l
0.94
79
804
6
42
1.44
0.36
2.7
2.5
1.23
1.19
mmol/l
—
6
42
6
43
1.40
0.35
2.7
2.5
107.67
105.79
mmol/l
—
6
43
6
90
0.66
0.33
1.5
1.1
—
—
—
0
0
6
90
0.66
0.33
1.5
1.1
—
—
—
0
0
17
137
1.26
0.33
8.5
8.0
15.06
15.54
%
0.33
17
130
7
53
1.33
0.31
1.4
1.1
3.77
3.89
mmol/l
—
7
47
27
313
0.85
0.31
1.4
1.5
—
—
—
0
0
10
76
1.33
0.28
1.1
1.3
—
—
—
0
0
26
298
0.86
0.26
6.5
4.8
27.76
21.50
%
0.62
16
155
29
254
1.16
0.26
7.3
7.8
118.34
119.00
g/l
0.06
29
248
25
287
0.86
0.26
5.7
5.3
35.78
33.57
%
0.38
18
179
209
2132
0.89
0.25
6.4
5.3
1.50
1.55
mmol/l
0.79
193
1943
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
2.7
—
13.41
—
0
14
16
138
1.17
0.18
1.2
1.2
111.52
129.57
u/ml
—
9
58
231
2282
1.12
0.17
17.9
13.0
23.67
23.48
u/l
0.08
225
2205
211
2141
0.92
0.16
6.5
5.5
4.52
4.67
mmol/l
1.33
196
1960
11
93
1.19
0.14
2.5
1.7
—
—
—
0
0
25
229
1.10
0.13
2.0
2.4
33.65
32.28
u/l
0.10
20
184
23
214
1.08
0.09
3.4
2.5
2.72
5.05
ug/l
3.32
23
190
13
144
0.90
0.08
2.4
2.3
3.29
3.24
ratio
—
8
126
11
98
1.13
0.08
2.6
1.9
—
—
—
0
0
8
75
1.07
0.07
1.5
1.4
—
—
—
0
0
216
2144
1.05
0.06
6.7
5.6
6.14
5.98
mmol/l
0.85
194
1945
10
110
0.91
0.05
1.3
1.4
—
—
—
0
0
60
586
1.03
0.04
7.5
4.7
1.01
1.02
kg/l
4.39
41
390
38
369
1.03
0.03
7.2
5.8
2.59
3.03
ug/l
0.16
29
325
34
347
0.98
0.01
1.4
1.4
—
—
—
0
0
11
109
1.01
0.00
1.7
2.0
3.68
3.48
mmol/l
—
6
87
204
2044
0.99
0.00
5.4
4.5
1.40
1.25
mmol/l
2.37
186
1857
17
166
1.03
0.00
10.6
6.5
26.08
24.95
mmol/l
0.50
17
158
218
2184
0.99
0.00
7.4
6.4
2.50
2.67
mmol/l
2.08
201
1989
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
5
50
1.00
-0.00
1.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
5
56
0.89
-0.00
1.0
1.1
—
14.23
—
0
6
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
68.72
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
50
1.00
-0.00
1.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_PARANAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_PARANAS | 1.495 [1.3, 1.72] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.123 |
During the follow-up period (1.1.1998 — 31.12.2019), 411 out of 1112 females with E4_PARANAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_PARANAS | 1.696 [1.3, 2.22] | < 0.001 |
| Birth year | 0.985 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 129 out of 310 males with E4_PARANAS died.
Mortality risk
Mortality risk for people of age
years, who have E4_PARANAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.142% | 0.283% |
| 5 | 0.791% | 1.52% |
| 10 | 2.046% | 4.214% |
| 15 | 4.067% | 8.631% |
| 20 | 7.273% | 14.569% |
Relationships between endpoints
↥Index endpoint: E4_PARANAS – Disorders of parathyroid gland, other and/or unspecified
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data