hereditary hemochromatosis type 1: Hemochromatosis type 1 (classic) is the most common form of hereditary hemochromatosis (HH), a group of diseases characterized by excessive tissue iron deposition. Due to its incidence (1/200-1/1000), it is not considered as a rare disease, unlike the other subforms of the disease
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
690 |
4. Check minimum number of eventsNone |
690 |
5. Include endpointsNone |
690 |
6. Filter based on genotype QC (FinnGen only) |
614 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E83
- Name in latin
- Perturbationes metabolismi ferri
Similar endpoints
↥List of similar endpoints to
Disorders of iron metabolism
based on the number of shared cases.
Similar with more cases:
- Disorders of mineral metabolism
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2585 | 1043 | 1510 |
| Only index persons | 2299 | 965 | 1334 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.03 | 0.04 |
| Only index persons | 0.04 | 0.04 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 55.61 | 56.88 | 54.60 |
| Only index persons | 55.33 | 56.71 | 54.33 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 614 | 293 | 321 |
| Unadjusted period prevalence (%) | 0.13 | 0.10 | 0.15 |
| Median age at first event (years) | 56.33 | 55.41 | 57.17 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 646
- Matched controls
- 6460
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E83.1
ICD-10 Finland
Disorders of iron metabolism
4503599627370496.0
307.7
638
*
TPH00
NOMESCO Finland
Phlebotomy
203.5
142.0
143
9
SPAT1074
SPAT
Venesection
125.0
90.8
96
9
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
12.5
75.7
78
70
TPH00, ,
SPAT
214.9
74.9
76
*
B99
ICPC
Blood/lymph/spleen disease other
120.2
61.1
65
6
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
12.9
58.2
58
49
M14.5*E83.1
ICD-10 Finland
Arthropathy in haemochromatosis
+∞
48.6
46
*
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
11.2
33.4
36
34
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.9
33.0
109
318
K76.9
ICD-10 Finland
Liver disease, unspecified
9.5
24.9
30
33
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
10.4
24.9
28
28
B04
ICPC
Blood symptom/complaint
24.1
15.2
21
9
Z31.5
ICD-10 Finland
Genetic counselling
3.5
14.7
52
157
B28
ICPC
Limited function/disability (B)
37.0
14.5
18
5
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
5.8
14.2
26
46
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
16.2
14.0
22
14
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
4.1
13.9
39
100
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
3.1
12.5
54
185
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.0
12.4
155
865
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.3
11.1
96
464
R53
ICD-10 Finland
Malaise and fatigue
1.9
11.0
160
939
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
10.5
179
1105
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
4.7
10.3
24
53
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
10.9
9.8
18
17
TPW99
NOMESCO Finland
Other minor surgical procedure on peripheral vessel or lymphatic system
9.8
9.8
19
20
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
2.1
9.6
98
504
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
4.3
9.4
24
57
XW000
NOMESCO Finland
Bone marrow biopsy
3.3
9.4
35
109
2750A
ICD-9 Finland
Disorders of mineral metabolism, Disorders of iron metabolism[HAEMOCHROMATOSIS]
+∞
9.4
9
*
M14.5
ICD-10 Finland
Arthropathies in other endocrine, nutritional and metabolic disorders
+∞
9.4
9
*
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.5
8.9
56
234
V03AC03
ATC
deferasirox; oral
+∞
8.3
8
*
R94.5
ICD-10 Finland
Abnormal results of liver function studies
6.8
7.6
18
27
D75.1
ICD-10 Finland
Secondary polycythaemia
10.2
7.6
14
14
C22.0
ICD-10 Finland
Malignant neoplasm: Liver cell carcinoma
10.2
7.6
14
14
F41
ICD-10 Finland
Other anxiety disorders
4.3
7.5
19
45
D64.9
ICD-10 Finland
Anaemia, unspecified
2.3
7.5
60
280
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
7.5
142
895
SPAT1377
SPAT
Polysomnography
3.4
7.5
26
78
B74
ICPC
Malignant neoplasm blood other
81.0
7.4
8
*
C03DA01
ATC
spironolactone; oral
2.2
7.4
66
322
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
7.4
279
2096
D83.1
ICD-10 Finland
Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
+∞
7.3
7
*
127
Kela drug reimbursment
Transplant complication
6.4
7.3
18
29
G47.3
ICD-10 Finland
Sleep apnoea
1.7
7.2
158
1035
ZXA10
NOMESCO Finland
Bilateral
1.9
7.2
101
581
SPAT1263
SPAT
Sampling
1.6
7.1
246
1808
JN3AD
NOMESCO Finland
Abdominal CT examination
2.0
7.0
82
443
R06.0
ICD-10 Finland
Dyspnoea
1.7
7.0
156
1026
M16.1
ICD-10 Finland
Other primary coxarthrosis
2.0
6.9
74
388
R03AC02
ATC
salbutamol; inhalant
1.5
6.8
337
2672
E86
ICD-10 Finland
Volume depletion
22.8
6.7
9
*
H02AB06
ATC
prednisolone; systemic
1.5
6.7
285
2186
R79.8
ICD-10 Finland
Other specified abnormal findings of blood chemistry
7.9
6.6
14
18
K73.80
ICD-10 Finland
Non-alcoholic fatty liver (NASH, Non Alcoholic Steatohepatitis)
12.4
6.6
11
9
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
3.2
6.5
25
80
UJF30
NOMESCO Finland
Ileoscopy through colon
2.0
6.3
67
349
E78.00
ICD-10 Finland
Familial hypercholesterolaemia
9.4
6.3
12
13
N02AJ06
ATC
codeine and paracetamol; systemic
1.5
6.3
270
2067
E83.0
ICD-10 Finland
Disorders of copper metabolism
+∞
6.3
6
*
L04AA06
ATC
mycophenolic acid; systemic
4.0
6.2
17
43
A02BC02
ATC
pantoprazole; systemic
1.5
6.0
410
3442
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
520
825
28.19
307.65
8.3
2.3
22.73
13.94
umol/l
69.73
506
778
520
764
30.77
307.65
8.1
2.3
2.16
2.35
g/l
11.71
500
714
510
696
31.06
307.65
8.0
2.3
43.22
23.87
%
66.64
497
659
592
2565
16.65
140.36
13.0
2.8
237.59
133.70
ug/l
8.67
576
2423
114
6
230.11
113.57
1.0
1.0
—
—
—
0
0
343
1275
4.60
81.67
3.8
2.1
2.38
3.00
mg/l
6.44
309
1114
187
503
4.82
65.95
3.0
2.5
0.24
0.22
g/l
2.72
178
472
396
1888
3.84
61.15
4.0
3.2
33.08
33.49
u/l
0.09
376
1793
428
2248
3.68
54.75
6.5
5.0
37.18
36.24
g/l
3.27
406
2123
476
2862
3.52
45.19
8.3
6.7
13.30
11.31
umol/l
1.62
468
2748
579
4187
4.69
36.52
11.9
8.1
78.90
78.15
u/l
0.16
566
3985
400
2343
2.86
36.37
13.5
11.6
1.18
1.19
inr
0.33
349
1948
100
278
4.07
32.33
2.0
1.7
0.34
0.36
mg/l
0.10
49
126
473
3157
2.86
31.22
9.1
10.1
3.56
4.02
e9/l
5.49
424
2767
137
501
3.20
29.04
2.2
2.1
357.05
362.03
nmol/l
0.12
130
477
146
567
3.03
27.81
3.9
5.1
219.43
240.29
u/l
1.77
138
548
251
1308
2.50
26.68
5.7
3.8
89.80
91.28
%
0.41
243
1282
528
3941
2.86
24.40
5.4
3.2
58.95
46.27
u/l
2.47
513
3745
128
497
2.96
24.14
2.4
2.8
10.96
10.49
g/l
0.71
117
466
110
393
3.17
23.98
1.5
1.7
0.95
1.31
g/l
2.53
100
363
256
1409
2.35
23.46
2.5
3.0
621.75
877.85
ng/l
1.21
203
1179
380
2470
2.31
23.43
16.8
10.3
0.00
0.00
e9/l
0.51
318
2045
379
2526
2.21
21.11
10.0
7.0
1.22
1.21
mmol/l
1.01
320
2174
526
4056
2.60
20.24
5.0
4.2
9.27
10.66
mm/h
1.64
503
3796
340
2245
2.09
18.50
8.6
6.5
1.22
1.21
mmol/l
0.96
314
2066
352
2384
2.05
17.54
3.0
2.4
73.20
76.75
nmol/l
1.57
320
2158
524
4165
2.37
16.61
5.1
3.9
14.71
14.67
pmol/l
0.15
486
3847
205
1163
2.12
16.30
1.6
1.5
2.54
2.49
g/l
0.13
158
757
236
1432
2.02
15.49
3.0
2.5
358.40
341.87
umol/l
1.78
214
1275
216
1281
2.03
15.03
1.4
1.3
1.24
1.47
u/ml
0.15
63
372
61
203
3.21
14.78
1.6
2.3
1.21
1.50
g/l
1.56
49
180
332
2293
1.92
14.69
2.3
2.0
97.04
98.18
pmol/l
0.17
181
1229
128
626
2.30
14.55
4.4
2.7
8.71
7.96
umol/l
0.14
121
557
39
97
4.21
14.46
1.2
1.2
14.70
37.80
u/l
1.04
34
83
147
765
2.19
14.37
2.0
1.6
1249.64
1219.26
nmol/l
0.14
117
595
33
78
4.40
13.05
1.1
1.0
—
—
—
0
0
232
1469
1.90
12.97
2.0
1.6
19.52
19.83
nmol/l
0.09
184
1245
32
76
4.38
12.58
1.3
1.2
—
—
—
0
0
580
5032
2.49
11.65
6.5
4.7
1.94
1.88
mu/l
0.41
544
4658
145
813
2.01
11.40
4.6
3.6
0.81
0.83
mmol/l
1.11
136
779
122
643
2.11
11.34
2.8
2.4
14.89
14.03
nmol/l
0.59
108
604
28
68
4.26
10.71
2.4
2.6
34.79
32.60
pg
2.08
28
68
254
1737
1.76
10.57
3.3
2.4
59.32
63.33
u/l
0.35
236
1621
243
1642
1.77
10.53
3.5
2.7
0.03
0.06
estimate
0.25
106
483
66
282
2.49
10.02
3.0
3.3
4.58
4.52
pmol/l
0.22
55
254
115
621
2.04
9.94
10.3
5.5
1.03
1.01
mmol/l
0.48
106
584
277
1995
1.68
9.22
4.2
3.1
24.83
78.96
ng/l
0.89
189
1339
161
1002
1.81
9.00
2.0
1.7
430.04
36830257.43
pmol/l
1.07
131
858
251
1775
1.68
8.87
3.4
3.5
2.35
2.35
mmol/l
0.16
228
1621
392
3115
1.66
8.70
6.5
4.8
6.68
6.56
mmol/l
0.55
377
2951
18
37
4.98
8.40
1.0
1.1
—
—
—
0
0
233
1647
1.65
8.08
4.1
3.5
0.00
0.00
estimate
0.80
117
564
584
5245
2.18
8.07
7.3
5.6
37.06
38.50
mmol/mol
4.40
562
4953
220
1544
1.64
7.79
2.1
2.1
152.89
238.57
u/l
0.86
209
1471
600
5487
2.31
7.25
20.1
13.6
18.73
23.79
mg/l
4.08
516
4433
130
806
1.77
7.22
2.0
1.9
1.69
1.45
%
2.36
114
715
296
2273
1.56
6.99
3.7
3.2
0.00
0.01
estimate
0.78
107
504
363
2926
1.55
6.83
3.9
3.4
0.01
0.00
estimate
0.50
120
604
76
404
2.00
6.79
4.0
3.2
1.23
1.23
mmol/l
0.23
61
349
358
2891
1.53
6.58
4.0
3.4
0.00
0.00
estimate
0.50
119
595
161
1087
1.64
6.47
1.3
1.3
33.87
34.95
iu/ml
0.03
31
322
172
1181
1.62
6.46
2.7
2.3
4.29
5.59
e6/l
0.72
159
1079
26
86
3.11
6.41
1.5
1.3
—
—
—
0
0
90
518
1.86
6.35
3.7
3.0
—
—
—
0
0
586
5359
2.01
6.30
6.2
4.7
5.87
5.87
mmol/l
0.02
553
4953
30
111
2.79
6.10
1.6
1.5
166.67
164.50
au/ml
—
6
31
63
326
2.03
6.07
5.8
3.7
85.30
84.65
ng/l
0.02
53
288
32
127
2.60
5.70
5.0
1.7
—
—
—
0
0
357
2937
1.48
5.63
4.0
3.4
0.00
0.53
estimate
0.50
115
571
170
1200
1.57
5.59
1.8
1.7
1.23
1.17
mg/l
0.11
137
936
33
136
2.50
5.46
10.2
5.4
1870.20
222.59
iu/ml
—
5
17
145
1005
1.57
5.12
1.3
1.3
12.34
12.77
u/ml
0.02
62
414
47
243
2.01
4.57
1.9
2.1
10.70
8.20
iu/ml
—
8
60
601
5639
1.94
4.56
22.9
15.2
139.72
139.80
mmol/l
0.37
594
5532
602
5652
1.96
4.55
23.2
15.4
3.97
3.97
mmol/l
0.21
595
5531
196
1482
1.46
4.52
3.3
2.9
0.46
0.42
e6/l
0.06
154
1087
409
3542
1.42
4.38
3.3
3.0
—
—
—
0
0
50
270
1.92
4.31
2.2
1.9
35.84
39.98
nmol/l
1.03
50
263
221
1726
1.43
4.24
3.5
3.0
18.60
86.29
e6/l
1.10
182
1338
63
369
1.78
4.22
1.2
1.2
201.67
148.92
u/ml
0.30
26
158
33
157
2.16
4.01
1.3
1.4
318.21
270.64
ug/g
0.56
19
98
9
14
6.50
3.99
4.9
3.5
3.33
5.85
ug/l
—
9
14
51
286
1.85
3.94
3.7
3.6
2.19
1.71
mmol/l
0.44
34
225
217
1710
1.41
3.90
4.5
3.9
8.16
5.98
mg/mmol
0.47
134
1037
25
108
2.37
3.80
2.2
4.8
3435.63
456.71
u/ml
0.42
25
102
290
2411
1.37
3.73
2.0
1.9
1.46
1.35
mmol/l
1.21
227
2054
576
5389
1.64
3.73
19.2
12.7
82.77
84.27
ml/min/173m2
1.08
540
4989
57
337
1.76
3.72
2.2
1.8
—
—
—
0
0
32
160
2.05
3.45
1.6
4.0
43.29
72.27
mg/l
0.36
27
137
32
160
2.05
3.45
1.6
4.0
37.64
31.16
mg/l
0.56
27
140
394
3461
1.35
3.44
4.6
4.1
1124.00
607.89
e6/l
—
7
47
82
546
1.57
3.41
9.9
9.8
0.80
0.94
mmol/l
0.12
72
450
9
18
5.05
3.38
1.3
2.0
196.56
198.61
u/l
—
9
18
225
1820
1.36
3.36
3.8
3.2
8.10
8.38
mmol/l
0.36
186
1523
21
89
2.41
3.35
4.1
2.4
8.84
6.54
pmol/l
0.85
21
89
588
5556
1.65
3.32
5.6
4.8
4.54
4.69
mmol/l
3.62
563
5224
586
5537
1.63
3.25
5.5
4.7
1.39
1.45
mmol/l
3.57
559
5166
616
5904
1.93
3.20
18.2
11.2
31.30
27.61
u/l
5.16
610
5752
11
29
3.84
3.19
2.1
3.6
56.27
117.86
nmol/l
0.61
11
29
53
323
1.70
3.13
3.2
3.0
165.67
162.02
ng/l
0.03
45
293
35
189
1.90
3.07
1.8
1.3
3.65
7.08
u/l
4.94
28
157
562
5274
1.50
3.07
4.7
4.0
1.34
1.28
mmol/l
1.37
530
4895
27
133
2.08
3.05
1.3
1.2
221.83
269.35
u/ml
0.30
12
80
132
1007
1.39
2.78
2.5
2.9
2.44
2.44
mmol/l
0.27
115
911
43
258
1.71
2.72
6.9
4.6
24.60
24.38
mmol/l
0.14
43
258
590
5627
1.56
2.62
6.3
5.3
2.68
2.79
mmol/l
2.28
566
5258
101
743
1.43
2.61
2.4
2.5
104.14
107.21
ug/g
0.03
71
602
31
171
1.85
2.59
1.4
1.2
—
2.17
—
0
15
6
11
5.49
2.55
4.0
2.5
0.55
0.62
mmol/l
—
6
11
24
122
2.00
2.53
1.5
1.7
4.16
4.30
iu/l
—
8
46
10
32
3.16
2.44
1.6
2.9
732.80
1370.34
u/ml
—
10
32
292
2539
1.27
2.40
3.8
2.7
—
—
estimate
—
0
0
17
77
2.24
2.39
1.4
1.7
—
—
—
0
0
23
118
1.98
2.38
1.1
1.1
0.60
2.73
u/ml
—
9
61
25
133
1.92
2.34
3.6
4.2
8.19
8.16
kpa
0.03
25
133
25
133
1.92
2.34
2.4
2.8
1.50
2.47
index
0.32
12
77
29
165
1.79
2.23
1.3
1.2
—
—
—
0
0
25
137
1.86
2.16
1.4
1.2
—
30.96
—
0
16
5
10
5.03
2.07
2.8
2.1
5.09
5.08
kpa
—
5
10
5
10
5.03
2.07
2.8
2.1
10.34
9.95
kpa
—
5
10
6
15
4.03
2.04
1.0
2.7
41.52
41.42
g/l
—
6
15
8
26
3.10
2.02
1.0
1.2
162.65
137.86
iu/ml
—
8
26
26
148
1.79
2.01
1.7
3.6
1.46
2.26
ratio
0.90
13
89
7
21
3.36
1.97
3.4
3.0
—
—
—
0
0
16
78
2.08
1.92
1.3
1.3
30.66
26.01
u/l
0.18
16
69
13
58
2.27
1.92
1.1
1.3
256.18
317.35
mu/l
0.70
13
49
12
52
2.33
1.88
2.5
3.3
1.52
3.06
nmol/l
3.02
12
52
7
22
3.20
1.88
1.1
1.0
—
—
—
0
0
31
190
1.66
1.87
1.4
2.1
0.29
1.46
g/l
1.84
26
168
21
116
1.84
1.80
3.4
2.1
139.31
129.61
g/l
0.72
16
96
69
509
1.40
1.80
2.8
5.2
2.96
29.48
ug/l
1.02
56
416
26
155
1.71
1.75
3.8
1.7
—
—
—
0
0
9
36
2.52
1.74
2.3
2.5
—
—
—
0
0
90
698
1.34
1.72
5.1
4.3
30.57
31.77
%
0.52
68
461
62
456
1.40
1.65
8.2
3.7
2.28
1.93
mmol/l
0.26
55
393
131
1078
1.27
1.62
1.7
1.5
—
—
—
0
0
157
1320
1.25
1.62
3.2
2.3
—
—
—
0
0
114
922
1.29
1.62
4.0
3.4
834.87
515.94
ng/l
0.19
76
671
29
183
1.61
1.60
1.3
1.4
251.12
208.58
miu/ml
—
10
89
16
86
1.88
1.51
1.1
1.1
—
—
—
0
0
33
219
1.53
1.49
2.3
1.9
2.02
3.31
ug/l
0.37
33
196
6
22
2.74
1.43
1.3
1.0
—
—
—
0
0
35
238
1.50
1.42
1.6
1.8
1.81
3.26
mg/l
1.47
29
176
26
165
1.60
1.42
3.9
1.7
—
—
—
0
0
18
103
1.77
1.42
1.1
1.1
—
1.65
—
0
8
15
81
1.87
1.41
1.7
1.6
—
—
—
0
0
27
174
1.58
1.39
3.9
2.0
230.58
7098.87
u/l
1.64
12
67
71
551
1.32
1.38
1.6
1.8
3.31
3.52
mmol/l
0.89
45
388
101
823
1.27
1.37
3.2
2.9
3.56
1.88
e6/l
0.67
48
407
28
183
1.55
1.36
1.5
1.4
—
—
—
0
0
64
490
1.34
1.36
5.5
2.5
32.42
128.63
u/l
0.50
48
425
10
47
2.15
1.34
2.2
1.2
129.20
112.57
pmol/l
—
10
47
12
61
1.99
1.33
1.2
1.1
—
—
—
0
0
6
24
2.51
1.30
1.3
1.0
—
—
—
0
0
6
24
2.51
1.30
1.8
1.7
0.67
1.95
u/field
—
6
19
85
683
1.28
1.29
8.0
7.7
103.65
104.71
mmol/l
1.10
85
683
10
48
2.10
1.28
1.5
1.6
—
—
—
0
0
8
35
2.30
1.27
1.6
2.4
938.25
1364.74
mg
—
8
35
12
64
1.89
1.18
1.5
1.3
—
—
—
0
0
0
33
0.00
1.16
0.0
1.4
—
—
—
0
0
10
52
1.94
1.06
1.3
1.1
—
—
—
0
0
7
33
2.13
1.06
1.4
6.5
—
91.75
—
0
8
75
611
1.26
1.05
2.0
1.8
—
—
—
0
0
89
740
1.24
1.04
1.9
2.1
3.71
3.57
ratio
0.50
67
579
9
46
1.97
1.04
1.1
1.1
—
—
—
0
0
5
22
2.28
1.03
2.6
1.4
45.20
53.58
ug/l
—
5
22
5
22
2.28
1.03
11.2
2.4
—
—
—
0
0
5
22
2.28
1.03
11.2
2.4
—
—
—
0
0
7
34
2.07
1.03
1.0
1.1
—
—
—
0
0
9
47
1.93
1.02
1.3
1.1
—
—
—
0
0
9
47
1.93
1.02
1.0
1.0
—
—
—
0
0
9
47
1.93
1.02
5.3
2.7
329.00
226.32
e6/l
—
9
41
88
733
1.23
1.01
1.4
1.5
—
—
—
0
0
9
48
1.89
1.00
1.3
1.1
—
—
—
0
0
17
107
1.60
1.00
4.4
2.0
—
—
—
0
0
24
342
0.69
0.99
2.1
2.0
—
—
—
0
0
5
23
2.18
0.98
11.2
2.3
—
—
—
0
0
97
820
1.22
0.98
2.7
1.9
—
—
—
0
0
9
50
1.81
0.97
1.3
1.1
—
—
—
0
0
9
50
1.81
0.97
1.3
1.1
—
—
—
0
0
55
436
1.29
0.96
1.4
1.5
—
—
—
0
0
24
166
1.46
0.95
2.1
1.3
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
20
133
1.52
0.95
3.2
2.7
0.27
0.30
iu/ml
—
7
65
6
27
2.23
0.93
9.3
2.2
—
—
—
0
0
6
27
2.23
0.93
9.3
2.2
—
—
—
0
0
6
27
2.23
0.93
9.2
2.2
—
—
—
0
0
6
27
2.23
0.93
9.5
2.2
—
—
—
0
0
6
28
2.15
0.91
1.7
1.6
—
—
—
0
0
620
6102
1.40
0.90
38.7
20.8
235.99
248.65
e9/l
5.46
608
6001
620
6103
1.39
0.89
38.6
20.7
93.46
90.93
fl
30.79
615
6045
70
578
1.24
0.89
2.2
1.8
—
—
—
0
0
10
56
1.80
0.88
1.0
1.1
—
—
—
0
0
620
6104
1.39
0.88
38.7
20.8
4.52
4.57
e12/l
1.48
606
5981
620
6104
1.39
0.88
39.5
21.3
41.69
41.06
%
2.17
615
6041
238
2185
1.14
0.87
4.5
5.1
1.89
2.28
ug/l
0.73
216
1993
8
45
1.79
0.84
5.4
2.5
416.25
438.62
e6/l
—
8
37
620
6107
1.38
0.84
38.9
20.9
141.41
137.95
g/l
5.70
615
6049
20
138
1.46
0.82
1.8
1.5
—
—
—
0
0
8
47
1.71
0.81
2.0
1.3
83.88
78.23
umol/l
—
8
47
18
122
1.49
0.81
1.1
1.3
2.22
34.55
e6/l
—
9
91
10
58
1.74
0.80
2.2
1.4
—
—
—
0
0
17
115
1.49
0.77
1.6
1.5
—
—
—
0
0
6
34
1.77
0.76
1.2
1.1
1554.83
1503.18
miu/ml
—
6
34
36
280
1.30
0.76
3.6
3.0
1.25
1.34
%
0.17
36
280
18
124
1.46
0.75
1.1
1.4
78.00
1073.56
e6/l
0.56
11
97
11
67
1.65
0.75
1.2
1.3
—
—
—
0
0
104
909
1.17
0.75
2.9
2.7
0.77
1.07
e6/l
0.73
51
495
9
54
1.68
0.74
1.2
1.5
269.38
343.33
pmol/l
—
9
54
7
39
1.80
0.72
1.1
1.1
—
—
—
0
0
19
134
1.43
0.72
1.3
1.2
—
—
—
0
0
25
186
1.36
0.71
1.6
1.6
45.72
10.53
u/ml
—
6
52
148
1341
1.13
0.66
3.0
3.1
0.75
0.71
ug/l
0.20
84
830
10
62
1.62
0.65
1.5
1.3
1.74
2.98
ug/l
—
10
55
5
29
1.73
0.64
1.0
1.6
—
—
—
0
0
5
29
1.73
0.64
2.2
1.4
65.80
100.32
ng/l
—
5
29
14
96
1.47
0.62
1.4
1.2
6.67
3.89
u/ml
—
6
44
14
96
1.47
0.62
1.4
1.3
2.22
4.65
u/ml
—
9
34
21
278
0.75
0.61
2.1
2.0
—
—
—
0
0
25
192
1.31
0.60
4.2
4.1
24.64
24.74
mmol/l
0.10
25
185
13
89
1.47
0.58
1.0
1.1
—
—
—
0
0
6
37
1.63
0.55
1.7
1.6
—
—
—
0
0
6
38
1.58
0.54
1.7
1.6
—
—
—
0
0
6
38
1.58
0.54
1.2
1.4
—
—
—
0
0
6
38
1.58
0.54
1.2
1.4
—
—
—
0
0
10
66
1.52
0.52
1.1
1.1
—
—
—
0
0
51
436
1.18
0.51
2.6
2.1
0.76
0.34
e6/l
0.41
51
418
11
75
1.47
0.51
3.4
1.5
—
—
—
0
0
6
41
1.47
0.50
1.7
1.6
—
—
—
0
0
34
280
1.23
0.50
3.5
3.0
0.57
0.63
%
0.69
34
280
11
76
1.46
0.48
3.4
1.5
—
—
—
0
0
12
165
0.72
0.47
1.5
1.4
—
—
—
0
0
19
147
1.30
0.45
1.1
1.2
—
—
—
0
0
21
165
1.28
0.45
1.6
1.7
—
—
—
0
0
16
121
1.33
0.44
1.9
1.5
—
—
—
0
0
7
51
1.38
0.44
8.0
1.8
—
—
—
0
0
7
51
1.38
0.44
8.3
1.8
—
—
—
0
0
7
51
1.38
0.44
8.0
1.8
—
—
—
0
0
67
598
1.13
0.41
1.9
1.9
—
—
—
0
0
23
186
1.25
0.41
1.8
1.7
—
—
—
0
0
50
437
1.16
0.41
3.0
2.5
63.69
70.23
ml/min/173m2
0.55
26
174
8
61
1.32
0.39
8.0
2.2
—
—
—
0
0
31
261
1.20
0.39
1.4
1.4
—
—
—
0
0
56
627
0.88
0.36
7.4
6.1
—
—
—
0
0
12
90
1.34
0.36
1.6
1.3
—
—
—
0
0
12
90
1.34
0.36
1.6
1.3
—
—
—
0
0
15
117
1.29
0.35
2.3
1.5
—
—
—
0
0
16
126
1.28
0.35
1.8
1.4
—
—
—
0
0
6
44
1.37
0.34
2.2
2.9
—
—
—
0
0
72
656
1.11
0.33
2.1
2.1
—
—
—
0
0
7
53
1.32
0.31
1.0
1.2
—
—
—
0
0
123
1308
0.93
0.30
3.6
3.4
1.02
1.02
kg/l
0.09
84
853
21
250
0.83
0.30
1.1
1.1
1.46
1.53
g/l
0.62
21
250
7
54
1.30
0.30
10.3
3.3
—
—
—
0
0
10
75
1.34
0.30
3.6
1.5
—
—
—
0
0
10
76
1.32
0.28
3.6
1.5
—
—
—
0
0
18
150
1.21
0.26
1.1
1.2
—
—
—
0
0
8
67
1.20
0.26
7.8
2.1
—
—
—
0
0
10
78
1.29
0.24
3.6
1.5
—
—
—
0
0
14
169
0.82
0.24
1.3
1.5
—
—
—
0
0
183
1759
1.06
0.24
3.7
4.2
24.32
20.86
%
1.80
68
831
11
136
0.81
0.23
1.4
1.4
—
—
—
0
0
16
188
0.85
0.21
5.1
2.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
81.64
—
0
11
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
6
48
1.25
0.20
2.0
2.1
1.19
1.19
mmol/l
—
6
48
6
48
1.25
0.20
1.3
1.2
1.05
1.44
nmol/l
—
6
42
6
48
1.25
0.20
1.0
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
6
49
1.23
0.20
2.0
2.1
105.50
105.41
mmol/l
—
6
49
22
195
1.13
0.17
2.1
1.6
0.64
0.10
iu/ml
—
5
26
9
78
1.16
0.15
3.9
1.5
—
—
—
0
0
23
255
0.90
0.15
1.4
1.2
0.90
0.91
g/l
0.02
23
255
9
83
1.09
0.14
3.4
1.8
12.67
13.10
%
—
9
83
7
87
0.80
0.14
1.6
1.7
—
—
—
0
0
32
295
1.09
0.14
1.1
1.0
—
—
—
0
0
18
160
1.13
0.14
1.8
1.4
—
—
—
0
0
8
96
0.83
0.14
2.0
1.6
—
—
—
0
0
19
172
1.11
0.11
1.7
1.5
—
—
—
0
0
20
185
1.08
0.08
4.3
2.1
—
—
—
0
0
5
65
0.77
0.08
1.0
1.1
111.80
97.29
%
—
5
59
19
176
1.08
0.07
1.7
1.9
—
—
—
0
0
8
76
1.05
0.07
1.4
1.6
75.63
50.42
ug/l
—
8
76
8
76
1.05
0.07
1.1
1.1
—
—
—
0
0
11
100
1.10
0.05
2.3
1.6
—
—
—
0
0
29
278
1.05
0.04
1.1
1.3
—
—
—
0
0
22
227
0.97
0.01
2.5
1.7
—
—
—
0
0
27
275
0.98
0.00
1.9
1.6
—
—
—
0
0
13
127
1.02
0.00
1.9
1.5
—
—
—
0
0
10
102
0.98
0.00
1.7
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
8.4
—
—
—
0
0
6
63
0.95
0.00
3.3
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
8.9
—
10.77
—
0
7
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
83.88
—
0
8
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
69
0.87
-0.00
1.5
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
6
62
0.97
-0.00
1.3
2.0
13.17
10.40
mmol/l
—
6
62
Mortality – FinRegistry
↥Association
Association between endpoint E4_IRON_MET and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_IRON_MET | 1.819 [1.37, 2.42] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.43 |
During the follow-up period (1.1.1998 — 31.12.2019), 117 out of 700 females with E4_IRON_MET died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_IRON_MET | 2.068 [1.7, 2.51] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.012 |
During the follow-up period (1.1.1998 — 31.12.2019), 233 out of 1047 males with E4_IRON_MET died.
Mortality risk
Mortality risk for people of age
years, who have E4_IRON_MET.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.185% | 0.41% |
| 5 | 1.129% | 2.443% |
| 10 | 2.835% | 6.134% |
| 15 | 5.252% | 11.96% |
| 20 | 8.954% | 19.321% |
Relationships between endpoints
↥Index endpoint: E4_IRON_MET – Disorders of iron metabolism
GWS hits: 6
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data