hypothyroidism: Abnormally low levels of thyroid hormone.
Hypothyroidism due to medicaments and other exogenous substances
DOID EFO Endpoint Browser PheWeb
E4_HYTHYSUBS
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
504 |
4. Check minimum number of eventsNone |
504 |
5. Include endpointsNone |
504 |
6. Filter based on genotype QC (FinnGen only) |
446 |
Control definitions (FinnGen only)
- Control exclude
- E4_THYROID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E03
- Name in latin
- Hypothyreosis ex medicamentis sive aliis substantiis externis
Similar endpoints
↥List of similar endpoints to
Hypothyroidism due to medicaments and other exogenous substances
based on the number of shared cases.
Similar with more cases:
- Hypothyroidism (congenital or acquired)
- Hypothyreosis and Thyroxine purchase for inclusion criteria
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2311 | 1701 | 600 |
| Only index persons | 2080 | 1546 | 534 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.02 |
| Only index persons | 0.05 | 0.06 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 61.87 | 61.63 | 62.70 |
| Only index persons | 60.73 | 60.33 | 61.91 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 446 | 318 | 128 |
| Unadjusted period prevalence (%) | 0.10 | 0.11 | 0.06 |
| Median age at first event (years) | 60.66 | 58.85 | 65.14 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 462
- Matched controls
- 4620
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
270.5
307.7
200
13
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
+∞
307.7
445
*
H03AA01
ATC
levothyroxine sodium; systemic
2473.8
307.7
448
59
H03BB01
ATC
carbimazole; oral
1297.1
239.2
213
*
104
Kela drug reimbursment
Thyroid insufficiency
700.7
156.7
146
*
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
+∞
155.2
140
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
749.3
121.0
114
*
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
+∞
76.2
71
*
C01BD01
ATC
amiodarone; systemic
18.0
71.3
60
38
E03.89
ICD-10 Finland
Other specified hypothyroidism
352.8
61.9
61
*
T86
ICPC
Hypothyroidism/myxoedema
119.0
58.4
62
6
E03
ICD-10 Finland
Other hypothyroidism
207.5
54.2
55
*
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
+∞
41.3
39
*
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
+∞
34.8
33
*
N05AN01
ATC
lithium; oral
10.5
33.4
38
39
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
80.2
27.1
30
*
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
102.9
27.0
29
*
C07AA05
ATC
propranolol; systemic
3.0
23.8
143
607
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
+∞
22.1
21
*
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
+∞
22.1
21
*
C07AB07
ATC
bisoprolol; oral
2.6
21.1
277
1709
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
7.5
19.7
29
41
BAA60
NOMESCO Finland
Total thyroidectomy
208.6
19.7
20
*
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
4.1
18.5
54
144
130
Kela drug reimbursment
Malignant tumour
3.5
17.9
68
217
EP1AE
NOMESCO Finland
Neck ultrasound examination
4.5
17.4
45
109
2443X
ICD-9 Finland
Acquired hypothyroidism, Other iatrogenic hypothyroidism
+∞
16.8
16
*
C64.88
ICD-10 Finland
Other malignant neoplasm of kidney, except renal pelvis
7.3
16.7
25
36
E05.89
ICD-10 Finland
Other thyrotoxicosis
+∞
15.7
15
*
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
46.7
15.2
18
*
N05AF03
ATC
chlorprothixene; systemic
6.8
15.1
24
37
1502
Kela drug reimbursment
Cabozantinib
37.4
14.5
18
5
3012
Kela drug reimbursment
Cabozantinib
37.4
14.5
18
5
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
14.1
256
1702
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
24.7
13.9
19
8
ZX120
NOMESCO Finland
Intravenous
3.0
13.7
65
237
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
13.6
13
*
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
13.5
13.0
22
17
TFP20
NOMESCO Finland
Cardiodefibrillation
3.4
13.0
49
155
C03CA01
ATC
furosemide; systemic
2.1
12.9
162
928
I47.2
ICD-10 Finland
Ventricular tachycardia
6.0
12.9
23
40
N05AX12
ATC
aripiprazole; systemic
5.2
12.8
27
55
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
+∞
12.6
12
*
WD325
NOMESCO Finland
Demanding therapy of methastized malignancy with biomodifiers
11.5
12.2
22
20
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.3
12.1
108
537
H02AB09
ATC
hydrocortisone; systemic
5.9
12.1
22
39
XF400
NOMESCO Finland
ECG with 12 standard connections
2.5
11.9
90
415
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
3.7
11.8
39
113
WD505
NOMESCO Finland
Simple enzyme inhibitor or similar therapy of methastized malignancy
13.0
11.7
20
16
D41.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Kidney
5.0
11.6
25
52
L01XE26
ATC
[U] cabozantinib
+∞
11.5
11
*
E05.1
ICD-10 Finland
Thyrotoxicosis with toxic single thyroid nodule
+∞
11.5
11
*
C07AA07
ATC
sotalol; systemic
4.6
11.3
27
61
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
25.8
11.2
15
6
WD515
NOMESCO Finland
Demanding therapy of malignancy with enzyme inhibitors and similar treatments
25.8
11.2
15
6
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
4.4
11.0
28
67
TPH07
NOMESCO Finland
Cathetrisation of artery
2.6
10.9
70
298
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.4
10.9
90
431
JN4CD
NOMESCO Finland
Very extensive body CT
4.5
10.9
27
63
C03DA01
ATC
spironolactone; oral
2.5
10.8
76
338
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.3
10.8
93
453
H02AB06
ATC
prednisolone; systemic
1.9
10.8
238
1641
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
3.9
10.8
32
86
T85
ICPC
Hyperthyroidism/thyrotoxicosis
61.5
10.7
12
*
F31.6
ICD-10 Finland
Bipolar affective disorder, current episode mixed
13.5
10.2
17
13
WX892
NOMESCO Finland
Monitored bed care
3.0
10.0
47
170
N05AH03
ATC
olanzapine; systemic
3.1
9.9
42
143
ZXE00
NOMESCO Finland
One hour or less
1.9
9.8
196
1296
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.2
9.8
39
128
Z2221
NOMESCO Finland
Medical doctor
2.0
9.7
148
894
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
8.7
9.7
20
24
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.2
9.6
88
440
168
Kela drug reimbursment
Axitinib
+∞
9.4
9
*
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.2
9.3
94
488
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
5.2
9.2
19
38
B01AB05
ATC
enoxaparin; parenteral
1.9
9.2
164
1043
ZXD10
NOMESCO Finland
Scheduled procedure
1.8
9.0
191
1281
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
24.6
8.9
12
5
L01EX07
ATC
cabozantinib; oral
24.6
8.9
12
5
Z3231
NOMESCO Finland
Registered nurse
1.9
8.8
144
888
ZXD05
NOMESCO Finland
Urgent procedure
1.9
8.7
154
972
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.0
8.7
112
635
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
2.5
8.7
58
251
JN4AD
NOMESCO Finland
Body CT examination
2.3
8.6
67
312
N05AA02
ATC
levomepromazine; systemic
3.6
8.5
28
81
197
Kela drug reimbursment
Sunitinib
34.0
8.1
10
*
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
34.0
8.1
10
*
ZXE10
NOMESCO Finland
More than one and less than three hours
1.8
8.1
179
1206
F31.0
ICD-10 Finland
Bipolar affective disorder, current episode hypomanic
7.4
8.0
18
25
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
8.0
117
693
WW200
NOMESCO Finland
Immunization
4.8
7.9
18
39
N03AG01
ATC
valproic acid; systemic, rectal
2.9
7.9
38
139
I50.9
ICD-10 Finland
Heart failure, unspecified
2.2
7.9
75
379
ZYC01
NOMESCO Finland
Remote contact by phone
2.8
7.9
40
151
Z3226
NOMESCO Finland
Physiotherapist
2.0
7.9
96
533
N03AX09
ATC
lamotrigine; oral
3.2
7.7
30
97
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
2.8
7.6
38
142
A03FA01
ATC
metoclopramide; systemic, rectal
1.9
7.6
122
743
F31.4
ICD-10 Finland
Bipolar affective disorder, current episode severe depression without psychotic symptoms
10.3
7.6
14
14
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
2.5
7.6
51
222
207
Kela drug reimbursment
Chronic arrhythmias
2.1
7.5
84
451
WZC30
NOMESCO Finland
Teaching
2.0
7.5
88
481
B01AB04
ATC
dalteparin; parenteral
3.0
7.5
33
115
ZY010
NOMESCO Finland
Hospital outpatient
3.0
7.5
33
115
R50.9
ICD-10 Finland
Fever, unspecified
2.1
7.5
80
423
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.6
7.4
24
69
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.9
7.3
104
607
F31.8
ICD-10 Finland
Other bipolar affective disorders
6.4
7.3
18
29
L01EK01
ATC
axitinib; oral
+∞
7.3
7
*
361
Kela drug reimbursment
Axitinib
+∞
7.3
7
*
N03AE01
ATC
clonazepam; systemic
3.0
7.3
33
117
A28
ICPC
Limited function/disability NOS
1.9
7.2
96
548
R31
ICD-10 Finland
Unspecified haematuria
2.4
7.1
51
228
I42.0
ICD-10 Finland
Dilated cardiomyopathy
4.5
7.0
17
39
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.2
7.0
59
284
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
7.7
6.9
15
20
R4110
NOMESCO Finland
Physiotherapy
1.8
6.9
139
904
R53
ICD-10 Finland
Malaise and fatigue
1.8
6.9
130
830
N02BE01
ATC
paracetamol; systemic, rectal
2.4
6.8
421
3750
N05BA04
ATC
oxazepam; oral
1.8
6.8
132
849
159
Kela drug reimbursment
Pazopanib
40.7
6.8
8
*
I48.1
ICD-10 Finland
Persistent atrial fibrillation
3.2
6.7
27
89
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.9
6.7
94
546
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
4.1
6.7
18
45
WZC00
NOMESCO Finland
Treatment plan or consultation
1.7
6.7
176
1231
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
3.9
6.6
19
50
WF049
NOMESCO Finland
Radiotherapy of metastasis
3.2
6.5
25
80
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
6.5
123
784
322
Kela drug reimbursment
Sunitinib
70.8
6.4
7
*
C64
ICD-10 Finland
Malignant neoplasm of kidney, except renal pelvis
8.3
6.4
13
16
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.7
6.3
140
933
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.4
6.2
45
202
N05AH04
ATC
quetiapine; oral
1.9
6.1
86
498
B01AA03
ATC
warfarin; systemic
1.9
6.1
84
484
8310/3-C64.9
ICD-O-3
Clear cell adenocarcinoma, NOS, of kidney, NOS
6.8
6.1
14
21
ZXE20
NOMESCO Finland
More than three and less than five hours
2.0
6.0
66
351
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
213
131
29.31
270.72
6.7
1.6
4.34
4.46
pmol/l
0.54
198
119
145
46
45.48
232.65
2.8
1.2
5.52
1.45
iu/l
4.91
75
14
118
204
7.43
69.16
1.3
1.2
228.40
63.41
u/ml
0.95
57
67
445
3093
12.92
38.11
16.0
2.8
15.79
14.50
pmol/l
18.76
433
2808
117
369
3.91
32.44
6.3
1.9
409.30
369.15
nmol/l
1.29
112
344
37
42
9.49
30.20
2.6
1.3
59.80
19.37
ng/l
1.24
37
42
337
2091
3.26
28.93
11.1
6.7
1.22
1.21
mmol/l
0.29
287
1813
163
697
3.07
27.29
6.3
2.8
0.82
0.83
mmol/l
0.23
156
660
305
1876
2.84
24.94
10.0
6.0
1.22
1.21
mmol/l
0.15
288
1730
141
644
2.71
19.99
2.9
2.4
2.36
2.31
g/l
0.41
135
595
343
2379
2.72
19.85
19.0
9.5
4.01
4.11
e9/l
0.33
294
2067
133
600
2.71
19.24
3.1
2.4
20.34
23.25
%
1.65
128
562
92
344
3.09
18.79
9.7
6.5
9.82
9.69
mmol/l
0.06
87
327
141
689
2.51
17.05
3.1
2.4
11.75
13.20
umol/l
1.93
136
637
278
1822
2.32
17.03
7.5
4.6
35.06
35.69
g/l
1.12
266
1722
284
1899
2.29
16.29
3.2
2.5
75.57
77.97
nmol/l
0.79
262
1712
445
3725
6.29
16.05
18.1
3.9
2.64
1.90
mu/l
4.30
434
3428
278
1854
2.25
15.89
19.4
11.4
0.01
0.00
e9/l
0.25
229
1511
114
527
2.54
15.32
8.4
5.1
1.09
1.06
mmol/l
0.48
109
487
233
1470
2.18
15.01
6.2
3.4
2.36
2.36
mmol/l
0.07
216
1329
81
318
2.88
14.99
4.3
3.6
79.34
82.47
ng/l
0.15
73
281
311
2228
2.21
14.13
11.7
6.2
10.15
11.16
umol/l
1.26
300
2135
397
3176
2.78
13.71
15.5
7.9
77.63
78.78
u/l
0.27
382
3012
218
1405
2.04
12.61
4.9
3.2
28.00
31.38
u/l
1.26
207
1336
321
2402
2.10
12.02
8.5
4.7
6.89
6.61
mmol/l
1.14
307
2275
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
35
94
3.95
11.79
3.7
2.7
0.27
0.37
iu/ml
1.17
18
50
274
1956
1.98
11.47
3.9
3.0
122.80
114.93
ug/l
0.28
256
1828
198
1267
1.98
11.37
4.2
3.1
1785.01
1176.56
ng/l
1.49
182
1085
142
811
2.08
11.16
5.9
3.7
76.27
308.15
ng/l
1.83
117
623
178
1104
2.00
11.13
3.1
2.2
2.69
2.94
mg/l
0.57
155
956
204
1334
1.95
10.87
5.4
2.4
58.81
125.74
u/l
0.58
192
1245
267
1917
1.93
10.68
18.2
14.0
1.28
1.23
inr
0.83
216
1568
145
857
2.01
10.24
4.6
2.7
2.48
2.46
mmol/l
1.87
127
760
49
180
2.93
10.13
1.4
1.9
1.58
1.51
g/l
0.21
44
162
100
519
2.18
9.95
2.3
1.8
—
—
—
0
0
126
719
2.03
9.75
2.2
1.9
—
—
—
0
0
82
401
2.27
9.40
5.9
4.1
2.15
1.94
mmol/l
0.19
73
338
339
2698
1.96
9.28
6.8
4.8
2177.67
2452.94
e6/l
—
9
48
102
548
2.11
9.24
2.2
1.8
—
—
—
0
0
20
26
7.99
9.22
3.5
1.7
17.16
23.57
nmol/l
1.50
20
26
179
1193
1.82
8.47
5.5
3.1
0.28
0.46
e6/l
1.19
133
849
60
269
2.41
8.36
2.1
1.6
—
—
—
0
0
78
393
2.18
8.27
2.9
2.3
42.16
35.04
u/l
0.20
68
323
22
56
4.08
7.97
6.5
5.1
370.00
360.02
umol/l
0.08
16
51
198
1386
1.75
7.76
5.8
3.2
31.00
127.52
e6/l
1.19
153
1049
113
667
1.92
7.74
5.6
3.0
2.82
2.31
e6/l
0.23
63
302
88
477
2.04
7.69
8.5
7.3
12.13
11.94
kpa
0.13
81
460
88
477
2.04
7.69
8.5
7.3
4.97
5.15
kpa
1.14
81
458
367
3079
1.93
7.57
5.6
4.3
15.58
12.32
mm/h
2.79
346
2862
389
3331
2.06
7.53
39.1
19.4
13.92
13.66
%
2.70
384
3301
25
73
3.56
7.50
2.9
3.5
0.86
0.85
nmol/l
0.01
20
60
86
473
2.01
7.20
8.7
7.3
0.27
1.14
mmol/l
1.16
67
397
62
303
2.21
7.06
4.1
2.9
191.81
198.26
ng/l
0.05
53
270
438
3964
3.02
7.05
28.8
15.5
22.75
24.21
mg/l
0.54
398
3239
182
1272
1.71
7.00
1.8
1.7
20.39
21.07
nmol/l
0.25
162
1068
59
285
2.23
6.91
1.8
1.8
—
—
—
0
0
145
957
1.75
6.81
3.7
2.5
6.21
5.61
e6/l
0.24
129
870
17
40
4.37
6.80
3.6
2.8
11.58
13.21
index
0.33
12
28
282
2242
1.66
6.42
5.5
4.0
15.66
7.39
estimate
0.21
77
474
239
1827
1.64
6.32
2.5
2.1
90.84
96.18
pmol/l
1.06
137
929
212
1576
1.64
6.25
6.3
3.9
27.10
56.65
ng/l
0.74
169
1131
82
467
1.92
6.16
4.0
2.7
5.20
7.44
umol/l
1.78
69
408
113
716
1.77
6.03
5.3
2.9
1.08
1.11
e6/l
0.02
64
350
142
965
1.68
5.87
1.8
1.7
1.73
1.23
mg/l
0.76
100
777
277
2226
1.61
5.75
5.5
4.0
0.00
0.00
estimate
0.50
74
472
191
1409
1.61
5.65
5.0
3.2
7.18
7.14
mmol/l
0.03
169
1189
280
2262
1.60
5.64
5.6
4.0
0.00
0.69
estimate
0.52
70
451
8
5
16.24
5.43
1.5
2.0
16.41
19.26
umol/l
—
8
5
29
114
2.65
5.32
3.7
3.4
2.94
2.08
index
0.56
17
64
67
376
1.91
5.24
2.3
2.2
0.22
0.21
g/l
0.61
61
363
28
111
2.62
5.06
3.8
2.2
138.76
126.75
g/l
1.15
21
86
182
1363
1.55
4.87
5.6
4.0
11.81
7.71
mg/mmol
0.60
121
823
146
1041
1.59
4.84
2.6
2.6
333.18
335.22
umol/l
0.07
123
919
241
1925
1.53
4.77
3.0
2.7
—
—
estimate
—
0
0
173
1306
1.52
4.36
2.6
2.1
173.70
254.13
u/l
0.75
163
1243
32
148
2.25
4.19
2.3
3.9
29.75
66.19
mg/l
0.85
27
124
30
135
2.31
4.18
2.3
3.5
9.50
2.66
ratio
0.37
17
71
11
21
5.34
4.16
1.8
1.9
89.97
54.76
ug/l
0.70
11
21
100
673
1.62
4.15
1.9
1.7
1107.96
1255.16
nmol/l
1.09
85
496
138
1004
1.53
4.08
2.6
2.2
—
—
—
0
0
17
58
3.00
4.05
1.2
1.6
—
—
—
0
0
69
426
1.73
3.96
3.8
3.3
—
—
—
0
0
27
119
2.35
3.95
1.9
1.5
—
—
—
0
0
27
120
2.33
3.88
1.6
1.3
—
—
—
0
0
12
28
4.37
3.84
3.3
2.8
0.83
0.89
index
0.14
12
28
31
148
2.17
3.78
2.4
3.9
58.69
87.54
mg/l
0.26
26
125
26
116
2.32
3.71
1.3
1.6
—
—
—
0
0
42
228
1.93
3.65
4.7
4.4
2.01
2.03
mmol/l
0.01
30
174
16
57
2.87
3.56
1.4
1.4
0.57
33.94
nmol/l
0.49
16
51
26
120
2.24
3.45
1.3
1.6
—
—
—
0
0
415
3857
1.75
3.31
30.3
15.0
76.41
80.21
ml/min/173m2
2.83
395
3579
9
19
4.81
3.25
1.4
1.6
—
—
—
0
0
26
124
2.16
3.20
2.2
2.5
—
—
—
0
0
22
100
2.26
3.04
1.3
1.2
—
—
—
0
0
39
222
1.83
2.96
1.7
1.5
—
—
—
0
0
21
95
2.27
2.94
1.2
1.3
—
—
—
0
0
7
14
5.06
2.73
1.3
1.3
360.29
113.07
iu/ml
—
7
14
15
62
2.47
2.56
1.2
1.6
—
—
—
0
0
48
304
1.65
2.54
2.2
2.3
12.87
7.06
ug/l
0.49
43
266
15
322
0.45
2.52
1.6
1.9
3.21
3.48
mmol/l
—
10
233
14
57
2.50
2.47
1.6
1.1
1.86
1.82
u/ml
—
7
17
37
220
1.74
2.46
1.7
1.4
25.35
26.04
iu/l
0.04
31
190
447
4302
2.20
2.45
45.7
23.7
4.37
4.44
e12/l
2.50
440
4207
305
2724
1.35
2.42
3.8
3.2
50.57
46.18
u/l
0.43
288
2567
15
65
2.35
2.34
1.2
1.2
12.23
16.29
u/l
0.60
15
57
123
968
1.37
2.25
1.3
1.3
1.66
2.35
u/ml
0.24
32
264
16
73
2.23
2.23
1.3
1.8
—
—
—
0
0
24
419
0.55
2.20
2.0
2.1
3.12
3.44
ratio
0.72
18
330
275
2445
1.31
2.11
3.3
3.0
—
—
—
0
0
23
124
1.90
2.11
1.4
1.2
—
—
—
0
0
400
3766
1.46
2.08
7.6
6.3
40.86
39.11
mmol/mol
2.61
378
3546
12
50
2.44
2.04
1.1
1.1
—
15.87
—
0
8
408
3871
1.46
1.88
6.6
5.1
6.07
5.90
mmol/l
1.68
379
3547
6
17
3.56
1.84
2.2
2.4
111.33
98.00
%
—
6
17
201
1738
1.28
1.83
2.1
1.9
1.46
1.32
mmol/l
1.35
169
1464
419
4002
1.50
1.79
6.6
5.8
2.61
2.71
mmol/l
1.60
393
3713
97
762
1.35
1.78
1.4
1.3
14.63
9.98
u/ml
0.24
30
286
17
88
1.97
1.77
1.2
1.5
—
—
—
0
0
12
54
2.25
1.75
2.8
1.2
—
—
—
0
0
9
36
2.53
1.75
1.2
1.1
—
—
—
0
0
36
235
1.58
1.74
2.2
2.3
11.64
12.64
nmol/l
0.36
31
220
47
326
1.49
1.73
6.0
2.6
57.32
65.07
ml/min/173m2
0.94
25
136
62
455
1.42
1.72
2.5
1.8
1.47
1.47
%
0.03
53
398
196
1700
1.27
1.71
5.6
3.9
0.00
0.03
estimate
1.81
58
390
13
62
2.13
1.67
4.7
2.2
31.69
32.37
pg
0.18
13
62
6
19
3.19
1.66
1.0
1.1
—
—
—
0
0
23
135
1.74
1.65
1.3
1.5
0.00
0.14
iu/ml
—
9
22
10
42
2.41
1.62
1.3
1.7
—
—
—
0
0
12
56
2.17
1.62
1.4
1.1
4.57
2.32
u/ml
—
7
19
8
32
2.53
1.60
1.0
1.2
—
—
—
0
0
23
137
1.71
1.58
1.9
1.6
—
—
—
0
0
19
107
1.81
1.57
1.2
1.5
—
—
—
0
0
63
473
1.38
1.54
4.3
4.2
3.66
24.15
ug/l
0.81
54
390
8
33
2.45
1.54
1.0
1.2
—
—
—
0
0
412
3942
1.42
1.54
5.8
5.1
4.56
4.69
mmol/l
1.84
389
3674
106
865
1.29
1.49
1.8
1.8
440.49
17107523.62
pmol/l
0.78
89
719
9
37
2.46
1.48
1.2
1.8
—
—
—
0
0
9
38
2.40
1.46
1.0
1.1
—
—
—
0
0
9
38
2.40
1.46
1.1
1.7
—
—
—
0
0
7
28
2.52
1.45
1.1
1.7
—
—
—
0
0
144
1225
1.25
1.44
5.5
3.4
0.16
0.07
estimate
0.22
61
377
5
16
3.15
1.44
1.4
1.1
—
—
—
0
0
11
53
2.10
1.39
1.4
1.1
—
—
—
0
0
5
121
0.41
1.39
1.0
1.1
1.48
1.57
g/l
—
5
121
5
124
0.40
1.38
1.0
1.1
0.86
0.90
g/l
—
5
124
9
41
2.22
1.37
1.0
1.2
—
—
—
0
0
8
34
2.38
1.29
1.0
1.1
—
—
—
0
0
8
34
2.38
1.29
1.0
1.1
—
—
—
0
0
20
122
1.67
1.29
1.2
1.5
0.30
0.23
g/l
2.51
20
116
18
109
1.68
1.20
1.2
1.3
—
—
—
0
0
0
33
0.00
1.16
0.0
1.1
—
—
—
0
0
0
33
0.00
1.16
0.0
1.2
—
—
—
0
0
20
126
1.61
1.16
1.2
1.5
1.29
1.19
g/l
0.80
20
119
5
20
2.52
1.15
1.8
2.9
1.10
1.40
%
—
5
20
144
1254
1.22
1.14
6.4
4.0
0.00
0.01
estimate
0.74
72
445
7
30
2.35
1.12
1.1
1.7
—
—
—
0
0
8
40
2.02
1.12
2.1
1.2
88.25
112.82
pmol/l
—
8
40
408
3934
1.32
1.11
5.6
5.0
1.44
1.52
mmol/l
3.86
381
3644
17
104
1.66
1.11
1.1
1.5
322.10
308.97
ug/g
—
10
60
7
32
2.21
1.08
1.1
1.7
—
—
—
0
0
7
33
2.14
1.06
2.0
1.3
2.07
2.93
ug/l
—
7
27
392
3768
1.27
1.04
4.8
4.2
1.40
1.25
mmol/l
2.29
366
3456
5
22
2.29
1.03
1.8
1.4
62.20
71.14
umol/l
—
5
22
12
68
1.79
1.01
1.7
1.8
187.67
211.27
pmol/l
0.41
12
63
99
842
1.22
0.98
1.4
1.3
24.16
30.75
iu/ml
0.30
31
271
5
23
2.19
0.98
1.6
1.8
94.40
91.08
ng/l
—
5
23
9
50
1.82
0.97
1.3
1.2
—
—
—
0
0
9
51
1.78
0.95
1.7
1.3
—
—
—
0
0
7
37
1.91
0.94
1.3
1.4
—
—
—
0
0
6
27
2.24
0.93
2.0
3.1
981.67
624.79
ml
—
6
14
9
52
1.75
0.93
1.7
1.3
—
—
—
0
0
9
52
1.75
0.93
1.7
1.2
—
—
—
0
0
12
71
1.71
0.89
1.2
1.6
—
—
—
0
0
18
119
1.53
0.89
3.1
2.2
175.97
642.75
u/l
—
9
45
10
57
1.77
0.84
1.0
1.0
—
—
—
0
0
18
121
1.51
0.84
1.2
1.1
—
—
—
0
0
26
189
1.40
0.83
1.7
1.8
—
—
—
0
0
14
89
1.59
0.82
1.1
1.5
—
—
—
0
0
6
32
1.89
0.82
1.7
1.7
—
—
—
0
0
6
32
1.89
0.82
1.7
1.7
—
—
—
0
0
6
32
1.89
0.82
1.7
1.7
—
—
—
0
0
18
122
1.49
0.81
1.2
1.1
—
—
—
0
0
0
25
0.00
0.79
0.0
1.3
—
—
—
0
0
29
217
1.36
0.79
7.2
3.8
52.87
46.94
%
0.73
29
211
10
59
1.71
0.76
1.3
1.6
—
—
—
0
0
9
53
1.71
0.76
1.7
1.2
—
—
—
0
0
9
53
1.71
0.76
1.7
1.2
—
—
—
0
0
9
53
1.71
0.76
1.7
1.2
—
—
—
0
0
8
136
0.58
0.74
1.4
1.5
—
—
—
0
0
5
25
2.01
0.73
2.4
2.4
—
—
—
0
0
7
42
1.68
0.68
1.0
1.3
—
—
—
0
0
5
27
1.86
0.68
1.0
1.2
—
—
—
0
0
14
94
1.50
0.67
1.4
1.6
—
—
—
0
0
5
28
1.79
0.66
1.0
1.3
—
—
—
0
0
12
79
1.53
0.63
1.1
1.2
—
—
—
0
0
12
79
1.53
0.63
1.1
1.2
—
—
—
0
0
8
50
1.61
0.61
1.0
1.2
—
—
—
0
0
0
21
0.00
0.60
0.0
3.8
—
197.24
—
0
21
43
516
0.82
0.60
4.7
4.7
32.13
32.58
%
0.09
31
335
109
979
1.15
0.60
6.1
4.1
1.02
1.02
kg/l
0.17
84
649
8
52
1.55
0.59
1.1
1.3
6.61
7.13
mmol/l
—
8
44
8
52
1.55
0.59
1.8
1.8
—
—
—
0
0
11
72
1.54
0.59
1.2
1.2
—
—
—
0
0
9
60
1.51
0.54
1.4
1.5
—
—
—
0
0
7
46
1.53
0.48
1.1
1.2
—
37.80
—
0
5
14
102
1.38
0.48
1.6
1.3
—
—
—
0
0
28
227
1.25
0.48
2.0
1.9
—
—
—
0
0
20
157
1.29
0.44
1.5
1.5
0.22
0.34
mg/l
—
7
68
8
56
1.44
0.42
4.3
4.2
29.63
76.89
u/ml
—
8
56
5
34
1.48
0.40
1.0
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.3
—
9.17
—
0
18
81
739
1.12
0.37
1.5
1.5
—
—
—
0
0
6
42
1.43
0.35
1.2
1.0
—
—
u/ml
—
0
0
6
43
1.40
0.35
1.3
1.5
76.53
45.19
ug/l
—
6
43
14
109
1.29
0.34
1.1
1.3
—
—
—
0
0
39
444
0.87
0.33
10.2
6.9
—
—
—
0
0
101
941
1.09
0.31
4.5
5.6
2.02
2.85
ug/l
0.92
87
843
22
184
1.21
0.31
1.3
1.5
—
—
—
0
0
61
559
1.11
0.27
3.1
3.4
0.62
0.83
ug/l
1.55
41
366
14
113
1.25
0.27
1.4
1.7
—
—
—
0
0
12
95
1.27
0.26
1.5
1.3
4.47
3.79
mmol/l
0.89
12
88
34
377
0.89
0.22
2.7
2.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
31
344
0.89
0.20
2.5
2.0
—
—
—
0
0
6
51
1.18
0.19
1.2
2.5
10.37
10.43
mmol/l
—
6
51
17
147
1.16
0.18
1.6
1.9
—
—
—
0
0
79
749
1.07
0.17
3.5
4.8
26.43
21.86
%
0.90
26
381
22
199
1.11
0.13
1.3
1.4
—
—
—
0
0
26
240
1.09
0.11
1.2
1.3
—
28.88
—
0
19
5
44
1.14
0.10
1.0
1.5
—
—
—
0
0
10
114
0.87
0.09
1.2
1.1
—
2.13
—
0
15
16
145
1.11
0.09
1.6
1.8
—
—
—
0
0
6
54
1.11
0.09
5.3
4.4
—
—
—
0
0
6
54
1.11
0.09
4.3
2.7
106.67
105.94
mmol/l
—
6
54
6
54
1.11
0.09
4.3
2.7
1.24
1.18
mmol/l
—
6
54
12
107
1.12
0.08
3.2
3.6
23.08
26.22
u/ml
0.16
12
107
23
215
1.07
0.07
1.2
1.1
—
—
—
0
0
12
110
1.09
0.05
1.8
1.3
—
—
—
0
0
34
328
1.04
0.04
2.1
1.5
—
—
—
0
0
14
131
1.07
0.03
1.4
1.6
—
—
—
0
0
71
699
1.02
0.02
1.6
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
5.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYTHYSUBS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYTHYSUBS | 1.474 [1.22, 1.77] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.062 |
During the follow-up period (1.1.1998 — 31.12.2019), 266 out of 1295 females with E4_HYTHYSUBS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYTHYSUBS | 1.706 [1.2, 2.43] | 0.003 |
| Birth year | 0.991 [0.98, 1.0] | 0.059 |
During the follow-up period (1.1.1998 — 31.12.2019), 125 out of 448 males with E4_HYTHYSUBS died.
Mortality risk
Mortality risk for people of age
years, who have E4_HYTHYSUBS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.126% | 0.325% |
| 5 | 0.678% | 1.992% |
| 10 | 1.908% | 5.386% |
| 15 | 3.619% | 10.489% |
| 20 | 6.044% | 17.534% |
Relationships between endpoints
↥Index endpoint: E4_HYTHYSUBS – Hypothyroidism due to medicaments and other exogenous substances
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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