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Hyperosmolality and hypernatraemia

EFO MESH Endpoint Browser PheWeb

E4_HYPEROSMHNAT

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E87.0
  • Hospital discharge: ICD-9 — 2760
  • Cause of death: ICD-10 — E87.0
  • Cause of death: ICD-9 — 2760

2 out of 7 registries used, show all original rules.

633

4. Check minimum number of events

None

633

5. Include endpoints

None

633

6. Filter based on genotype QC (FinnGen only)

545

Control definitions (FinnGen only)

Control exclude
E4_METABOLIA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E87
Name in latin
Hyperosmolalitas

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6622 3751 2831
Only index persons 5696 3249 2447
Unadjusted period prevalence (%)
Whole population 0.09 0.11 0.08
Only index persons 0.11 0.12 0.09
Median age at first event (years)
Whole population 77.28 80.01 73.68
Only index persons 77.45 80.17 73.85

-FinnGen-

Key figures

All Female Male
Number of individuals 545 254 291
Unadjusted period prevalence (%) 0.11 0.09 0.13
Median age at first event (years) 72.84 72.59 73.05

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
559
Matched controls
5590
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E87.0
ICD-10 Finland
Hyperosmolality and hypernatraemia
+∞
307.7
556
*
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
110.6
273.2
141
17
E87.6
ICD-10 Finland
Hypokalaemia
31.0
91.4
61
22
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
5.1
80.0
262
819
E86
ICD-10 Finland
Volume depletion
131.1
75.1
79
7
N05AN01
ATC
lithium; oral
16.0
61.3
54
37
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
7.1
61.0
103
173
N05AH03
ATC
olanzapine; systemic
7.9
58.0
86
125
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.7
51.0
290
1264
N05AA02
ATC
levomepromazine; systemic
8.1
50.3
72
100
AA1AD
NOMESCO Finland
CT of head and brain
3.5
46.5
271
1183
N17.9
ICD-10 Finland
Acute renal failure, unspecified
7.8
46.4
68
97
N03AG01
ATC
valproic acid; systemic, rectal
6.3
44.5
82
149
N05AX08
ATC
risperidone; systemic
4.3
43.3
133
375
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.2
42.5
140
415
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.9
41.7
159
522
T36
ICD-10 Finland
Poisoning by systemic antibiotics
8.8
41.2
54
67
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.7
41.2
172
600
R41.0
ICD-10 Finland
Disorientation, unspecified
7.1
39.1
62
96
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
13.6
38.7
37
29
A28
ICPC
Limited function/disability NOS
3.3
37.5
205
840
N05AF03
ATC
chlorprothixene; systemic
11.3
37.0
40
38
N05AX12
ATC
aripiprazole; systemic
9.4
35.0
43
49
R53
ICD-10 Finland
Malaise and fatigue
3.0
33.6
212
935
N05AH04
ATC
quetiapine; oral
3.4
32.6
148
536
F20.9
ICD-10 Finland
Schizophrenia, unspecified
10.6
29.4
33
33
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
5.5
29.4
60
119
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
9.3
29.2
36
41
L28
ICPC
Limited function/disability (L)
2.9
28.8
183
800
E87.5
ICD-10 Finland
Hyperkalaemia
38.4
28.7
36
10
A06AD11
ATC
lactulose; oral
3.0
28.7
166
689
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
8.7
28.5
37
45
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.8
28.5
203
941
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
7.7
28.3
41
57
G72.8
ICD-10 Finland
Other specified myopathies
8.2
28.0
38
49
A10AB05
ATC
insulin aspart; parenteral
4.2
26.9
80
216
N04AA02
ATC
biperiden; systemic
9.6
26.7
32
35
R56.8
ICD-10 Finland
Other and unspecified convulsions
5.1
26.3
59
127
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
3.0
26.3
147
595
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
5.9
26.0
49
90
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
4.1
25.8
78
213
N05BA04
ATC
oxazepam; oral
2.7
25.8
205
997
N05BA06
ATC
lorazepam; systemic, sublingual
4.3
25.8
71
181
N05AC02
ATC
thioridazine; oral
9.1
25.6
32
37
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
3.2
24.5
111
396
N06AB04
ATC
citalopram; systemic
2.8
23.6
152
660
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
3.1
23.3
117
443
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
3.2
22.9
102
360
N03AF02
ATC
oxcarbazepine; oral
6.8
22.4
36
56
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
4.2
22.1
62
160
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
4.2
22.0
63
165
E23.2
ICD-10 Finland
Diabetes insipidus
83.5
21.8
24
*
L89
ICD-10 Finland
Decubitus ulcer and pressure area
6.6
21.7
36
58
N05AB03
ATC
perphenazine; systemic, rectal
5.7
21.7
42
79
103
Kela drug reimbursment
Diabetes, insulin-treated
2.5
21.6
204
1061
SPAT1234
SPAT
Support of social functional capacity
4.0
21.3
65
178
F05.9
ICD-10 Finland
Delirium, unspecified
6.6
21.2
35
56
N05CD07
ATC
temazepam; oral
2.9
21.2
123
503
A10AE04
ATC
insulin glargine; parenteral
3.3
21.1
87
292
G40.9
ICD-10 Finland
Epilepsy, unspecified
5.4
21.1
43
85
C03CA01
ATC
furosemide; systemic
2.3
21.0
275
1643
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.5
20.4
167
810
N03AX14
ATC
levetiracetam; systemic
6.6
19.5
32
51
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
4.0
19.3
58
157
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
3.6
19.0
68
208
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.2
18.8
244
1435
N05AA01
ATC
chlorpromazine; systemic, rectal
18.3
18.4
28
16
N05AH02
ATC
clozapine; systemic
15.0
18.3
30
21
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.6
18.2
133
608
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
3.2
18.1
80
279
SPAT1254
SPAT
Administration of medicine
2.6
18.1
132
602
102
Kela drug reimbursment
Diabetes insipidus
54.4
18.1
21
*
F31.6
ICD-10 Finland
Bipolar affective disorder, current episode mixed
25.0
17.5
24
10
N06AX11
ATC
mirtazapine; oral
2.2
17.2
216
1244
A10BA02
ATC
metformin; oral
2.2
17.0
199
1113
A04
ICPC
Weakness/tiredness general
2.6
16.8
120
540
H02AB09
ATC
hydrocortisone; systemic
6.9
16.7
26
39
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
7.2
16.7
25
36
P99
ICPC
Psychological disorders other
6.5
16.4
27
43
N05BA01
ATC
diazepam; systemic, rectal
2.7
16.4
102
429
ZXD05
NOMESCO Finland
Urgent procedure
2.2
15.9
184
1021
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
3.4
15.8
59
185
C08CA01
ATC
amlodipine; oral
2.1
15.8
260
1648
R50.9
ICD-10 Finland
Fever, unspecified
2.5
15.8
112
502
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.5
15.7
112
503
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
3.1
15.3
71
254
F31.0
ICD-10 Finland
Bipolar affective disorder, current episode hypomanic
18.4
15.3
23
13
SPAT1245
SPAT
Provision of support and information to patient’s family members
3.6
15.2
53
159
TPH07
NOMESCO Finland
Cathetrisation of artery
2.8
15.2
85
338
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.7
15.1
91
375
N05AD01
ATC
haloperidol; systemic
4.2
15.0
41
103
Z76.8
ICD-10 Finland
Persons encountering health services in other specified circumstances
4.5
15.0
38
90
R11
ICD-10 Finland
Nausea and vomiting
3.0
15.0
72
263
I50.9
ICD-10 Finland
Heart failure, unspecified
2.3
15.0
144
738
SPAT1301
SPAT
No procedures
2.1
14.9
214
1282
N03AX09
ATC
lamotrigine; oral
4.7
14.9
35
78
N25.1
ICD-10 Finland
Nephrogenic diabetes insipidus
+∞
14.6
14
*
N30.0
ICD-10 Finland
Acute cystitis
2.4
14.4
112
522
E78.00
ICD-10 Finland
Familial hypercholesterolaemia
17.5
14.4
22
13
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.3
14.2
123
601
E23.00
ICD-10 Finland
Panhypopituitarism
43.7
14.2
17
*
F25.9
ICD-10 Finland
Schizoaffective disorder, unspecified
14.9
14.2
23
16
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
11.3
14.1
26
24
F10.25
ICD-10 Finland
Alcohol dependence continuous use
10.4
14.1
27
27
I50.0
ICD-10 Finland
Congestive heart failure
2.7
14.0
86
358
T90
ICPC
Diabetes non-insulin dependent
2.2
13.8
156
849
SPAT1262
SPAT
Handing over of treatment supplies
2.3
13.6
122
605
188
Kela drug reimbursment
Psychosis requiring demanding treatment
26.5
13.4
18
7
A10AE05
ATC
insulin detemir; parenteral
3.5
13.2
47
143
SPAT1172
SPAT
Guidance concerning hydration
5.2
13.0
27
54
SPAT1216
SPAT
Assessment of functional ability
2.2
13.0
129
666
A41.9
ICD-10 Finland
Sepsis, unspecified
3.7
12.9
42
120
I10
ICD-10 Finland
Essential (primary) hypertension
2.0
12.9
381
2887
E78.9
ICD-10 Finland
Disorder of lipoprotein metabolism, unspecified
11.9
12.9
23
20
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
11.9
12.9
23
20
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.6
12.8
84
360
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
5.3
12.8
26
51
N05AF05
ATC
zuclopenthixol; systemic
12.7
12.7
22
18
F31.1
ICD-10 Finland
Bipolar affective disorder, current episode manic without psychotic symptoms
15.9
12.7
20
13
SPAT1307
SPAT
Psychosocial counselling and guidance
4.3
12.7
33
80
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.3
12.6
106
510
N06AB06
ATC
sertraline; oral
2.8
12.5
68
265
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
5.8
12.5
23
41
F10.20
ICD-10 Finland
Alcohol dependence currently independent
5.8
12.5
23
41
E87.8
ICD-10 Finland
Other disorders of electrolyte and fluid balance, not elsewhere classified
132.9
12.5
13
*
P72
ICPC
Schizophrenia
9.3
12.4
25
28
WX872
NOMESCO Finland
Intensive care
3.6
12.3
41
119
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
12.3
183
1097
P20
ICPC
Memory disturbance
2.1
12.2
133
710
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.6
12.0
40
116
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
13.8
12.0
20
15
N06AA12
ATC
doxepin; systemic
3.4
11.8
44
138
E83.50
ICD-10 Finland
Hypercalcemia
19.4
11.6
17
9
SPAT1229
SPAT
Assessment of need for aid
2.7
11.6
67
269
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.3
11.6
96
457
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.4
11.6
93
437
N06DX01
ATC
memantine; oral
2.3
11.4
94
447
N05CF01
ATC
zopiclone; oral
1.9
11.4
214
1381
F31.4
ICD-10 Finland
Bipolar affective disorder, current episode severe depression without psychotic symptoms
20.5
11.2
16
8
SPAT1263
SPAT
Sampling
1.9
11.2
244
1649
S06.0
ICD-10 Finland
Concussion
2.5
11.1
77
338
S97
ICPC
Chronic ulcer skin
2.8
11.0
60
234
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.9
11.0
174
1059
C09AA05
ATC
ramipril; oral
1.9
10.9
173
1054
N30.9
ICD-10 Finland
Cystitis, unspecified
2.9
10.9
52
189
SPAT1309
SPAT
Guidance related to psychoactive substances / risk behaviour
5.3
10.9
22
43
Y94.0
ICD-10 Finland
Accident at home
4.9
10.8
24
51
R55
ICD-10 Finland
Syncope and collapse
2.3
10.8
90
430
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
3.5
10.7
37
110
R73.9
ICD-10 Finland
Hyperglycaemia, unspecified
4.3
10.7
28
68
F29
ICD-10 Finland
Unspecified nonorganic psychosis
4.4
10.7
27
64
C07AB07
ATC
bisoprolol; oral
1.8
10.5
314
2318
P29
ICPC
Psychological sympt/compl other
3.4
10.5
38
117
R33
ICD-10 Finland
Retention of urine
2.4
10.4
75
335
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.1
10.4
117
629
N05BE01
ATC
buspirone; oral
4.4
10.4
26
61
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
3.4
10.3
37
113
F31
ICD-10 Finland
Bipolar affective disorder
19.2
10.3
15
8
F10.26
ICD-10 Finland
Alcohol dependence periodic alcoholism
13.4
10.2
17
13
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
4.1
10.2
28
71
F31.20
ICD-10 Finland
Bipolar disorder, manic episode with mood-congruent psychotic symptoms
14.9
10.0
16
11
F25.00
ICD-10 Finland
Schizoaffective syndrome, manic type with only simultaneous bipolar and schizophrenic symptoms
14.9
10.0
16
11
F03
ICD-10 Finland
Unspecified dementia
2.7
10.0
57
228
A10BH01
ATC
sitagliptin; oral
2.4
9.8
71
318
W19
ICD-10 Finland
Unspecified fall
2.3
9.8
77
358
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
7.6
9.8
22
30
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
5.4
9.7
19
36
F10.40
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without seizures
11.6
9.6
17
15
N19
ICD-10 Finland
Unspecified kidney failure
3.4
9.6
34
103
N06AX16
ATC
venlafaxine; oral
2.4
9.6
72
328
G30.1
ICD-10 Finland
Alzheimer disease with late onset
2.4
9.6
73
335
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
4.2
9.5
25
61
A10BH05
ATC
linagliptin; oral
3.0
9.5
44
157
N05BA02
ATC
chlordiazepoxide; systemic
4.4
9.5
24
57
F31.3
ICD-10 Finland
Bipolar affective disorder, current episode mild or moderate depression
30.6
9.4
12
*
F31.2
ICD-10 Finland
Bipolar affective disorder, current episode manic with psychotic symptoms
30.6
9.4
12
*
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.6
9.4
58
241
AA400
NOMESCO Finland
Electroconvulsive therapy
22.1
9.4
13
6
F10.09
ICD-10 Finland
Alcohol intoxication UNS
5.0
9.4
20
41
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
9.7
9.3
18
19
AN1
HP
Coronary angiography
2.3
9.3
72
332
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.3
9.3
78
373
EBA15
NOMESCO Finland
Extraction of multiple teeth
3.5
9.2
31
91
N06AB03
ATC
fluoxetine; oral
2.3
9.1
71
329
29570
ICD-8 Finland
Schizophrenia, Schizo-affective type
37.3
9.0
11
*
101
Kela drug reimbursment
Anterior pituitary hypofunction
19.0
9.0
13
7
C10AA01
ATC
simvastatin; oral
1.7
8.9
252
1804
K90
ICPC
Stroke/cerebrovascular accident
4.1
8.9
24
60
F31.8
ICD-10 Finland
Other bipolar affective disorders
9.7
8.8
17
18
SPAT1251
SPAT
Organisation of medication
3.3
8.8
33
104
9690A
ICD-9 Finland
Poisoning by psychotropic agents, Antidepressants
50.8
8.7
10
*
F10.24
ICD-10 Finland
Alcohol depence active use
7.5
8.5
19
26
E87.2
ICD-10 Finland
Acidosis
91.4
8.4
9
*
R63.1
ICD-10 Finland
Polydipsia
91.4
8.4
9
*
E000001, ,
ATC
2.0
8.4
109
614
Y57
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified drugs and medicaments
5.0
8.4
18
37
D64.9
ICD-10 Finland
Anaemia, unspecified
2.1
8.4
86
445
F00.10*G30.1
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
2.9
8.4
41
151
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.6
8.3
51
211
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.2
8.3
71
342
J01EA01
ATC
trimethoprim; systemic
1.8
8.3
157
999
TAB00
NOMESCO Finland
Lumbar puncture
3.2
8.2
32
103
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.9
8.2
114
658
N03AF01
ATC
carbamazepine; oral, rectal
2.8
8.2
42
159
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.5
8.0
52
221
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
4.0
8.0
22
56
C03DA01
ATC
spironolactone; oral
2.0
7.9
87
462
A10BB12
ATC
glimepiride; oral
2.3
7.9
61
281
SPAT1260
SPAT
Consultation of another employee
1.9
7.9
104
589
A08.4
ICD-10 Finland
Viral intestinal infection, unspecified
3.9
7.9
23
61
WX730
NOMESCO Finland
Conventional respirator
7.1
7.8
18
26
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.3
7.8
60
276
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
2.3
7.8
59
270
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.8
7.7
40
152
SPAT1305
SPAT
Counselling and guidance related to physical exercise
2.3
7.7
61
284
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.5
7.6
51
220
2957A
ICD-9 Finland
Schizophrenic psychoses, Schizo-affective type
18.7
7.6
11
6
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.6
7.6
44
177
N07BB01
ATC
disulfiram; oral
3.4
7.6
27
82
J01MA02
ATC
ciprofloxacin; systemic
1.7
7.6
228
1640
SPAT1255
SPAT
Intravenous administration of medicine
2.5
7.5
47
197
WX882
NOMESCO Finland
High dependency care
3.5
7.5
25
73
205
Kela drug reimbursment
Chronic hypertension
1.7
7.5
185
1264
29610
ICD-8 Finland
Affective psychoses, Manic-depression psychosis, manic type
81.1
7.4
8
*
K59.09
ICD-10 Finland
Constipation, unspecified
2.4
7.4
51
223
A10AC01
ATC
insulin (human); parenteral
2.3
7.4
57
262
F25.20
ICD-10 Finland
Schizoaffective syndrome, mixed type with only concomitant bipolar and schizophrenic symptoms
13.6
7.4
12
9
N06DA02
ATC
donepezil; oral
2.2
7.4
66
323
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.9
7.3
94
526
XA800
NOMESCO Finland
Neuropsychological investigation
3.6
7.3
24
69
E78.29
ICD-10 Finland
Other mixed hyperlipidaemia
+∞
7.3
7
*
F25
ICD-10 Finland
Schizoaffective disorders
+∞
7.3
7
*
E66.00
ICD-10 Finland
Metabolic syndrome
3.1
7.3
30
100
F10.49
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without information about seizures
16.0
7.3
11
7
F10.31
ICD-10 Finland
Withdrawal symptoms caused by alcohol with seizures
16.0
7.3
11
7
B01AC04
ATC
clopidogrel; oral
1.9
7.2
99
567
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
3.0
7.2
32
112
E83.51
ICD-10 Finland
Hypocalcemia
30.4
7.2
9
*
P16
ICPC
Acute alcohol abuse
6.7
7.2
17
26
29599
ICD-8 Finland
Schizophrenia, Unspecified type
20.3
7.2
10
5
F10.21
ICD-10 Finland
Alcohol dependence currently abstinent, but staying in restrictive environment
8.1
7.1
15
19
N06AB10
ATC
escitalopram; oral
1.9
7.1
92
516
J01CA08
ATC
pivmecillinam; oral
1.6
7.0
205
1457
UKC02
NOMESCO Finland
Cystoscopy
1.8
7.0
111
667
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
2.9
6.9
32
115
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.6
6.8
210
1509
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
2.0
6.8
73
383
E950A
ICD-9 Finland
Suicide and self-inflicted poisoning by solid or liquid substances
9.5
6.8
13
14
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.9
6.8
92
524
SPAT1053
SPAT
Memory test
1.8
6.8
114
695
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
2.8
6.8
34
127
N06AX03
ATC
mianserin; oral
2.7
6.8
35
133
2962C
ICD-9 Finland
Affective psychoses, Major depressive disorder, single episode[PSYCHOSIS BIPOLARIS MANICA,KESKIVAIKEA]
40.6
6.8
8
*
3018D
ICD-9 Finland
Personality disorders, Other personality disorders[EPÄVAKAA PERSOONALLISUUS]
16.9
6.8
10
6
J01DB01
ATC
cefalexin; oral
1.7
6.8
423
3609
A46
ICD-10 Finland
Erysipelas
1.9
6.7
94
541
F25.10
ICD-10 Finland
Schizoaffective syndrome, depressive type with only concomitant bipolar and schizophrenic symptoms
22.8
6.7
9
*
X44
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
7.9
6.6
14
18
E11.2
ICD-10 Finland
Type 2 diabetes mellitus, with renal complications
3.1
6.6
28
95
R25.1
ICD-10 Finland
Tremor, unspecified
3.5
6.6
22
64
N02AA05
ATC
oxycodone; systemic
1.7
6.6
131
838
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
3.7
6.5
20
55
SPAT1299
SPAT
Other function in accordance with podiatry nomenclature
5.4
6.5
18
34
N03AE01
ATC
clonazepam; systemic
2.6
6.5
38
154
N05AF01
ATC
flupentixol; systemic
5.8
6.5
17
30
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.7
6.5
165
1128
Z02.4
ICD-10 Finland
Examination for driving licence
0.5
6.4
72
1243
F31.31
ICD-10 Finland
Bipolar disorder depressive episode with somatic syndrome
70.6
6.4
7
*
OAB43, ,
SPAT
0.3
6.4
13
476
N06AX21
ATC
duloxetine; oral
2.1
6.4
59
293
G25.9
ICD-10 Finland
Extrapyramidal and movement disorder, unspecified
6.7
6.4
15
23
R60.0
ICD-10 Finland
Localized oedema
1.9
6.3
82
460
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
3.9
6.3
18
47
N12
ICD-10 Finland
Tubulo-interstitial nephritis, not specified as acute or chronic
3.9
6.3
18
47
Z51.5
ICD-10 Finland
Palliative care
2.0
6.3
71
380
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
2.5
6.3
40
169
G21.1
ICD-10 Finland
Other drug-induced secondary parkinsonism
18.3
6.3
9
5
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.3
6.3
45
201
R99
ICD-10 Finland
Other ill-defined and unspecified causes of mortality
2.9
6.3
29
104
N05AE04
ATC
ziprasidone; systemic
27.0
6.2
8
*
SPAT1304
SPAT
Counselling and guidance related to ageing
2.0
6.2
65
338
R06.0
ICD-10 Finland
Dyspnoea
1.7
6.2
155
1053
N02BE01
ATC
paracetamol; systemic, rectal
1.8
6.2
477
4242
H02AA02
ATC
fludrocortisone; oral
6.4
6.2
15
24
110
Kela drug reimbursment
Parkinson's disease and comparable movement disrorders
3.0
6.2
26
88
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
2.7
6.2
32
122
TPH04, ,
SPAT
7.8
6.2
13
17
SPAT1240
SPAT
Therapeutic discussion
2.4
6.1
40
171
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
6.1
118
748
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.7
6.1
31
117
A29
ICPC
General symptom/complaint other
1.9
6.0
84
483

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
116
48
30.23
168.09
2.1
1.3
66.24
68.82
mmol/l
0.15
105
40
76
39
22.40
99.94
2.7
1.9
306.84
283.44
mosm/kgh2o
4.19
63
25
244
917
3.95
54.39
4.1
2.9
495.64
547.11
mosm/kgh2o
2.48
219
804
139
359
4.82
51.18
2.5
2.0
381.59
378.26
nmol/l
0.05
129
332
57
59
10.64
50.03
9.1
4.9
379.17
353.90
umol/l
0.46
48
51
177
561
4.15
49.70
6.2
5.1
1.01
1.01
mmol/l
0.03
171
505
71
100
7.99
49.00
2.1
3.2
28.53
39.38
umol/l
1.99
66
85
193
689
3.75
45.13
5.6
3.4
0.84
0.82
mmol/l
0.96
186
654
297
1417
3.34
43.31
6.9
4.0
—
—
—
0
0
144
468
3.80
38.02
5.0
3.4
2.47
1.92
mmol/l
0.88
133
403
142
481
3.62
34.99
4.9
3.3
7.38
7.39
ph
0.25
113
277
153
548
3.47
34.53
11.8
6.2
7.42
7.41
ph
0.19
107
339
152
545
3.46
34.22
11.7
6.2
1.61
1.30
mmol/l
0.42
132
430
273
1386
2.90
33.30
4.1
2.0
383.16
267.73
u/l
0.71
263
1306
109
331
3.85
31.35
5.1
3.9
7.41
7.42
ph
0.25
98
280
276
1532
2.58
26.56
5.1
3.4
—
—
—
0
0
371
2394
2.63
25.64
14.4
6.2
1.21
1.21
mmol/l
0.00
327
2031
341
2117
2.57
25.52
6.6
4.6
31.55
34.85
g/l
14.95
318
1951
358
2297
2.55
24.61
19.4
17.5
1.30
1.34
inr
0.72
327
1950
152
648
2.85
24.55
11.5
5.3
107.27
104.36
mmol/l
2.78
152
648
78
222
3.92
24.35
2.4
1.9
8.69
3.19
ug/l
0.55
70
191
93
303
3.48
23.75
7.2
4.5
—
—
—
0
0
394
2683
2.59
23.23
12.2
4.4
7.41
6.74
mmol/l
5.80
387
2553
196
977
2.55
22.96
2.1
1.7
1281.50
1173.84
nmol/l
0.67
155
745
45
89
5.41
22.03
1.4
1.4
4.43
3.73
mmol/l
2.23
45
82
253
1448
2.37
21.54
3.6
2.4
54.92
63.83
u/l
1.09
242
1327
357
2404
2.34
20.30
7.2
6.4
10.96
12.25
umol/l
1.34
340
2290
30
43
7.32
20.12
1.7
1.3
39.59
29.45
ng/l
0.22
30
43
157
746
2.54
19.96
2.6
2.3
2.19
2.28
g/l
0.89
144
680
327
2135
2.28
19.84
13.6
5.6
1.21
1.21
mmol/l
0.61
310
1934
113
463
2.81
19.27
2.0
2.3
0.20
0.20
g/l
0.06
102
428
46
107
4.59
18.63
1.4
1.4
535.80
489.53
mg/l
0.31
46
101
42
91
4.91
18.52
6.4
3.2
—
—
—
0
0
222
1286
2.20
17.49
2.7
2.2
3.08
3.23
mg/l
0.38
198
1096
291
1880
2.14
17.27
7.2
3.8
117.05
56.98
ng/l
0.50
258
1457
95
375
2.85
17.27
13.5
6.9
—
—
—
0
0
137
651
2.46
17.13
2.2
2.0
31.67
29.59
s
0.98
130
628
198
1109
2.22
16.84
3.5
2.6
6.35
5.38
e6/l
0.44
184
1010
159
814
2.33
16.77
2.8
2.3
9.82
12.37
umol/l
5.83
146
755
129
602
2.49
16.74
2.4
2.7
1.85
1.80
%
0.21
117
542
40
92
4.61
16.41
1.5
1.4
2.34
3.59
e6/l
0.52
35
71
142
700
2.38
16.28
2.7
2.3
19.09
21.94
%
1.64
130
644
88
345
2.84
16.15
3.5
3.3
85.30
86.83
ng/l
0.06
69
294
188
1052
2.19
15.86
1.9
1.8
462.10
20605793.21
pmol/l
0.75
155
859
44
113
4.14
15.69
3.9
2.0
124.79
126.49
g/l
0.16
38
89
249
1558
2.08
15.63
4.3
3.3
70.42
125.09
e6/l
0.60
218
1231
226
1396
2.04
14.40
6.5
3.6
7.40
7.40
ph
1.04
195
1006
102
460
2.49
14.07
2.1
3.0
69.09
67.42
e9/l
0.19
81
353
255
1717
1.89
12.06
5.0
3.8
301.82
145.09
e6/l
0.55
217
1266
213
1357
1.92
11.90
4.2
3.1
34.09
35.21
u/l
0.14
201
1268
267
1833
1.87
11.81
5.1
3.8
6.46
6.27
ph
2.01
168
1017
242
1614
1.88
11.69
3.8
3.2
2500.60
1715.97
ng/l
0.79
220
1391
389
3019
1.95
11.66
8.4
5.0
3254.38
3440.83
e6/l
0.03
16
54
104
512
2.27
11.65
2.6
1.8
—
—
—
0
0
279
1961
1.84
11.29
2.8
2.3
74.07
79.16
nmol/l
2.18
247
1715
207
1336
1.87
10.91
4.2
3.2
0.68
0.56
e6/l
0.39
183
1022
21
40
5.42
10.66
1.3
1.2
—
—
nmol/l
—
0
0
284
2040
1.80
10.41
9.5
6.1
0.49
0.65
%
5.59
264
1893
30
80
3.91
10.17
1.3
1.4
—
—
—
0
0
283
2041
1.78
10.14
9.6
6.2
8.22
9.13
%
5.54
262
1900
31
85
3.80
10.11
7.1
3.7
3.87
2.68
mmol/l
0.98
25
53
87
426
2.23
9.79
2.9
2.5
64.33
66.26
g/l
1.01
81
387
281
2037
1.76
9.77
9.5
6.0
62.38
57.97
%
6.08
265
1934
40
134
3.14
9.63
6.1
5.0
—
—
—
0
0
255
1805
1.76
9.58
6.9
4.2
0.04
0.04
estimate
0.03
75
432
280
2042
1.74
9.41
9.5
6.0
2.34
2.88
%
3.25
260
1894
301
2243
1.74
9.35
9.5
6.1
1.80
1.92
e9/l
0.48
281
1980
62
268
2.48
9.25
16.6
7.2
24.48
24.71
mmol/l
0.17
62
253
46
171
2.84
9.24
3.9
3.3
4.16
4.33
pmol/l
0.53
38
152
283
2078
1.73
9.22
9.9
6.2
23.16
26.56
%
4.73
267
1954
25
63
4.11
9.15
1.6
1.4
—
—
—
0
0
25
63
4.11
9.15
1.6
1.4
—
—
—
0
0
25
63
4.11
9.15
1.6
1.4
—
—
—
0
0
25
63
4.11
9.15
1.6
1.4
—
—
—
0
0
303
2271
1.73
9.14
9.6
6.2
0.17
0.20
e9/l
1.55
279
1979
296
2207
1.73
9.07
9.1
6.0
0.04
0.04
e9/l
2.35
274
1887
295
2199
1.72
9.04
9.4
5.9
0.63
0.61
e9/l
0.49
272
1881
307
2314
1.72
9.03
6.6
4.1
0.00
0.00
estimate
-0.00
93
510
152
937
1.85
8.98
1.9
1.7
1.58
1.49
mg/l
0.14
120
727
35
113
3.24
8.95
2.8
3.4
—
—
—
0
0
58
247
2.50
8.93
5.8
4.2
—
—
—
0
0
310
2348
1.72
8.91
6.7
4.2
0.00
0.00
estimate
0.50
93
527
311
2359
1.72
8.88
6.6
4.2
0.21
0.60
estimate
0.28
89
502
42
154
2.87
8.65
2.6
2.9
1.57
2.61
ratio
0.95
32
92
216
1494
1.73
8.56
2.1
1.7
19.43
19.78
nmol/l
0.11
194
1226
381
3074
1.75
8.54
7.6
4.6
—
2.60
—
0
6
83
422
2.14
8.47
3.6
2.4
7.76
7.35
ug/l
0.08
66
367
44
168
2.76
8.41
2.6
3.1
39.79
47.54
mg/l
0.18
37
143
44
168
2.76
8.41
2.6
3.1
56.31
79.09
mg/l
0.27
37
140
20
46
4.47
8.21
1.4
1.2
—
—
—
0
0
229
1625
1.69
8.17
3.2
3.3
2.33
2.35
mmol/l
1.50
210
1446
210
1456
1.71
8.16
8.3
6.1
—
—
—
0
0
80
407
2.13
8.14
3.1
2.3
0.29
0.46
e6/l
0.71
80
386
140
868
1.82
8.01
6.0
3.7
142.25
384.79
ng/l
1.70
117
724
408
3398
1.74
7.71
10.6
7.9
90.64
81.25
u/l
2.53
390
3195
260
1943
1.63
7.37
3.5
2.7
151.10
140.54
ug/l
0.33
238
1760
317
2490
1.63
7.32
15.4
9.3
5.17
4.19
e9/l
5.41
292
2174
182
1246
1.68
7.25
6.7
3.6
3.74
0.10
estimate
0.50
69
397
112
668
1.85
7.20
3.0
2.0
—
—
—
0
0
328
2608
1.62
7.13
5.2
3.2
64.56
51.07
u/l
1.79
310
2408
76
401
2.04
7.01
5.6
3.4
1.23
1.23
mmol/l
0.01
71
337
142
916
1.74
7.00
5.4
4.9
—
—
—
0
0
51
233
2.31
6.74
1.5
1.9
1.60
1.50
g/l
0.31
41
210
45
200
2.36
6.33
1.4
1.3
—
—
—
0
0
73
396
1.97
6.22
3.8
3.0
168.91
243.63
ng/l
1.79
68
368
16
28
5.85
6.18
1.1
1.1
2.17
1.89
mmol/l
0.67
16
28
85
490
1.87
6.04
2.8
3.2
7.12
9.62
umol/l
0.98
72
434
273
2133
1.55
5.99
2.8
2.1
96.29
97.01
pmol/l
0.09
151
1115
25
85
3.03
5.91
5.2
2.9
58.95
59.64
%
0.08
25
85
260
2026
1.53
5.68
3.5
2.8
—
—
estimate
—
0
0
20
61
3.36
5.63
2.2
3.1
4.63
4.69
e9/l
0.04
20
61
29
114
2.63
5.30
1.4
1.4
—
—
—
0
0
75
434
1.84
5.26
2.9
4.5
0.98
0.85
%
0.18
31
143
13
22
6.02
5.25
2.8
1.5
396.00
43.13
umol/l
—
6
15
26
98
2.73
5.15
1.1
1.1
—
—
—
0
0
9
9
10.14
5.04
1.3
1.3
194.33
127.07
mmol/24h
—
9
9
40
188
2.21
4.98
6.3
4.8
24.57
25.22
mmol/l
0.67
40
182
199
1498
1.51
4.94
4.6
3.8
15.87
7.41
mg/mmol
0.91
139
924
23
83
2.85
4.93
1.7
2.5
0.82
0.92
%
0.49
18
63
28
113
2.56
4.87
1.5
1.4
216.75
286.52
ug/g
1.12
16
70
65
371
1.85
4.76
6.5
3.7
—
—
—
0
0
153
1097
1.54
4.74
5.3
3.3
0.15
0.07
0.34
13
45
11
18
6.21
4.62
4.3
2.8
—
—
—
0
0
149
1068
1.54
4.60
6.7
4.5
1.02
1.02
kg/l
0.52
113
691
69
410
1.78
4.44
2.9
4.6
0.12
0.12
%
0.02
25
121
18
60
3.07
4.43
4.3
1.7
11.89
9.93
mmol/l
0.75
18
60
62
358
1.82
4.38
2.5
2.4
—
—
—
0
0
25
101
2.54
4.36
3.2
2.3
124.67
84.94
ug/min
0.19
18
54
15
38
4.03
4.33
1.2
1.5
—
—
—
0
0
187
1424
1.47
4.27
6.5
4.1
0.00
0.00
estimate
-0.00
71
460
33
153
2.23
4.27
1.4
1.5
0.17
0.38
mg/l
2.09
14
58
20
73
2.80
4.23
1.6
1.7
2.25
4.43
iu/l
—
8
24
68
409
1.75
4.20
3.1
4.5
0.76
0.50
%
0.46
29
131
188
1445
1.45
4.06
3.4
2.5
—
—
—
0
0
19
69
2.82
4.06
3.5
2.2
—
—
—
0
0
366
3181
1.44
3.95
6.0
4.0
15.28
15.08
pmol/l
0.70
335
2846
193
1504
1.43
3.83
3.8
3.2
5.62
7.32
mmol/l
9.38
166
1239
14
38
3.75
3.82
1.4
1.6
—
—
—
0
0
11
25
4.47
3.64
1.2
1.2
60.27
100.56
pmol/l
2.74
11
25
7
9
7.86
3.56
1.4
1.7
—
—
—
0
0
65
406
1.68
3.52
3.1
5.1
0.13
0.23
%
0.38
23
108
139
1039
1.45
3.40
3.1
3.0
2.48
2.46
mmol/l
0.58
124
927
15
53
2.88
3.38
3.9
2.8
—
—
—
0
0
13
38
3.48
3.33
3.3
2.5
—
—
—
0
0
6
7
8.65
3.27
2.5
2.6
20.67
20.67
umol/l
—
6
7
12
35
3.48
3.12
1.8
3.4
10.44
8.54
mmol/l
0.43
12
35
123
1610
0.70
3.10
2.4
1.9
1.60
1.29
mmol/l
1.28
100
1300
43
249
1.79
3.06
2.1
2.5
—
—
—
0
0
11
31
3.60
3.00
1.7
3.9
15.25
15.20
%
0.01
11
31
0
78
0.00
2.97
0.0
1.2
—
0.72
—
0
14
148
1144
1.40
2.97
2.8
2.8
379.50
353.52
umol/l
1.28
125
968
31
164
1.94
2.91
1.1
1.3
—
—
—
0
0
455
4201
1.45
2.91
40.3
16.7
31.24
27.09
mg/l
2.16
439
3514
17
70
2.47
2.90
3.1
2.2
—
—
—
0
0
142
1095
1.40
2.88
3.5
2.5
—
—
—
0
0
13
47
2.81
2.83
1.0
1.0
—
—
—
0
0
5
6
8.39
2.75
1.2
4.2
—
—
—
0
0
5
6
8.39
2.75
2.2
2.2
0.61
0.63
mmol/l
—
5
6
17
72
2.40
2.75
3.1
2.2
—
—
—
0
0
17
73
2.37
2.67
1.5
2.7
—
—
—
0
0
101
746
1.43
2.60
3.8
3.1
2.34
2.48
e6/l
0.07
67
389
11
36
3.10
2.57
1.3
1.3
—
—
—
0
0
5
7
7.20
2.55
1.0
1.0
—
—
—
0
0
6
11
5.50
2.55
1.0
1.2
—
—
—
0
0
135
1053
1.37
2.54
6.5
4.0
82.40
85.46
%
0.67
129
1034
17
75
2.31
2.53
3.1
2.2
—
—
—
0
0
17
75
2.31
2.53
3.1
2.2
—
—
—
0
0
32
180
1.83
2.53
1.1
1.5
—
21.16
—
0
5
8
21
3.85
2.47
1.3
1.2
99.13
86.00
umol/l
—
8
21
8
21
3.85
2.47
1.0
1.0
160.13
134.33
nmol/l
—
8
21
37
220
1.73
2.44
2.6
2.0
—
—
—
0
0
101
756
1.41
2.42
1.4
1.4
3.05
2.75
g/l
0.52
63
430
179
1468
1.32
2.40
3.8
3.2
89.95
40.62
mg/l
0.78
128
933
14
58
2.45
2.38
1.2
1.3
7.39
6.64
mmol/l
0.32
14
53
11
39
2.86
2.35
1.0
1.3
—
—
u/ml
—
0
0
24
126
1.95
2.34
1.4
1.2
—
—
—
0
0
74
527
1.47
2.32
9.6
3.2
5.03
4.87
e9/l
0.10
63
445
70
494
1.48
2.29
1.8
1.7
—
—
—
0
0
75
537
1.46
2.29
1.3
1.3
376.00
475.56
titre
—
10
126
14
61
2.33
2.16
1.0
1.0
—
—
—
0
0
5
10
5.03
2.07
1.8
1.6
—
—
—
0
0
383
4115
0.78
1.96
6.0
5.7
2.29
2.64
mmol/l
12.38
351
3700
22
120
1.87
1.95
1.0
1.2
—
378.00
—
0
5
156
1289
1.29
1.94
11.3
5.8
—
—
—
0
0
31
189
1.68
1.92
1.2
1.2
43.00
147.08
u/ml
—
10
80
413
3838
1.29
1.91
7.1
5.0
1.81
2.04
mu/l
2.78
375
3454
7
22
3.21
1.88
1.7
1.5
—
—
—
0
0
77
1006
0.73
1.83
2.5
3.3
0.77
0.81
ug/l
0.16
55
682
27
161
1.71
1.81
4.0
3.2
0.70
0.85
nmol/l
1.45
21
135
219
1899
1.25
1.81
23.8
11.9
0.00
0.00
e9/l
0.98
199
1565
7
23
3.07
1.80
1.7
1.2
256.29
243.53
mu/l
—
7
17
8
29
2.78
1.79
1.4
1.4
—
—
—
0
0
6
18
3.36
1.75
1.3
1.3
—
—
—
0
0
13
61
2.16
1.72
3.5
2.0
—
—
—
0
0
15
75
2.03
1.71
3.4
2.1
—
—
—
0
0
376
4025
0.80
1.69
5.5
5.0
4.14
4.55
mmol/l
12.03
345
3648
21
119
1.79
1.68
1.0
1.2
52.00
109.00
titre
—
5
10
372
3985
0.80
1.67
5.3
4.9
1.34
1.47
mmol/l
6.40
341
3577
14
69
2.06
1.66
1.1
1.6
—
—
—
0
0
7
25
2.82
1.65
1.3
2.1
48.40
37.97
%
—
7
25
51
365
1.44
1.60
5.6
3.1
6.20
6.09
ph
0.34
41
258
8
32
2.52
1.60
1.0
1.1
—
—
—
0
0
10
43
2.35
1.59
2.0
2.7
5.26
3.30
nmol/l
—
10
43
12
57
2.13
1.56
1.2
1.3
—
—
—
0
0
459
4363
1.29
1.52
54.4
19.9
140.12
139.72
mmol/l
0.77
453
4267
74
572
1.34
1.49
1.5
1.2
—
—
—
0
0
459
4371
1.28
1.44
53.0
20.1
3.98
4.00
mmol/l
1.05
454
4268
13
66
1.99
1.44
1.8
1.9
1.85
0.84
g/l
—
8
54
9
39
2.33
1.43
1.2
1.8
—
—
—
0
0
64
488
1.35
1.41
6.5
3.9
7.40
7.34
ph
4.37
52
350
146
1700
0.81
1.41
1.9
2.3
—
—
—
0
0
11
53
2.10
1.39
1.0
1.2
—
—
—
0
0
105
869
1.26
1.28
1.3
1.2
2.30
1.78
u/ml
0.13
29
220
8
36
2.24
1.24
1.3
1.3
—
—
—
0
0
6
25
2.41
1.24
1.3
1.2
—
—
—
0
0
6
25
2.41
1.24
4.0
2.4
526.33
502.07
min
—
6
14
50
378
1.35
1.19
1.4
1.6
—
—
—
0
0
6
26
2.32
1.19
1.5
1.1
—
—
—
0
0
66
521
1.30
1.17
1.8
1.5
—
—
—
0
0
26
174
1.52
1.17
1.1
1.1
—
37.50
—
0
6
57
443
1.32
1.14
1.6
1.6
—
—
—
0
0
7
30
2.35
1.12
1.0
1.0
7.39
7.40
ph
—
7
20
7
31
2.27
1.10
1.1
2.6
1046.71
1217.19
e6/l
—
7
26
5
21
2.39
1.09
1.0
1.5
—
—
—
0
0
9
49
1.85
0.99
1.1
1.3
—
—
—
0
0
462
4464
1.20
0.89
50.7
22.2
88.96
81.46
umol/l
3.05
455
4396
27
366
0.72
0.87
1.6
1.5
—
—
—
0
0
64
527
1.24
0.85
3.2
4.1
20.97
32.81
ug/l
0.28
56
444
13
80
1.64
0.85
1.6
1.4
—
—
—
0
0
6
31
1.95
0.84
1.2
1.3
—
—
—
0
0
49
391
1.28
0.84
2.7
2.4
44.45
34.79
u/l
0.27
40
323
58
474
1.25
0.83
2.2
2.1
207.07
146.19
ug/g
0.39
42
370
15
97
1.56
0.82
2.2
2.0
52.67
60.08
%
0.58
15
97
6
32
1.88
0.82
1.3
3.0
9.88
11.36
%
—
6
32
8
47
1.71
0.81
1.4
1.1
—
—
—
0
0
8
47
1.71
0.81
1.4
1.1
—
—
—
0
0
6
33
1.83
0.79
1.2
1.4
—
—
—
0
0
0
25
0.00
0.79
0.0
1.0
—
—
—
0
0
11
66
1.68
0.79
1.1
1.4
—
—
—
0
0
8
48
1.68
0.79
1.1
1.1
—
—
—
0
0
5
97
0.51
0.78
1.0
1.5
—
—
—
0
0
365
3813
0.88
0.76
4.7
4.2
1.39
1.24
mmol/l
3.01
334
3390
53
434
1.24
0.75
2.6
2.1
0.00
0.04
estimate
0.49
12
77
441
4265
1.16
0.73
36.8
15.3
—
—
—
0
0
55
661
0.81
0.73
1.4
1.3
14.40
11.61
u/ml
0.12
24
241
121
1355
0.86
0.73
4.3
3.3
—
—
—
0
0
23
169
1.38
0.70
1.7
3.1
138.36
248.78
mg/l
1.33
11
69
50
603
0.81
0.69
1.4
1.4
—
—
—
0
0
29
222
1.32
0.69
2.2
2.2
0.00
0.02
estimate
0.49
11
62
9
59
1.53
0.68
2.3
5.2
—
—
—
0
0
5
93
0.53
0.67
1.0
1.1
—
—
—
0
0
5
28
1.79
0.66
5.4
3.0
1.60
0.86
index
—
5
28
0
20
0.00
0.60
0.0
2.4
—
—
—
0
0
61
706
0.85
0.57
1.3
1.3
20.11
37.87
iu/ml
2.43
18
214
15
107
1.41
0.56
1.4
1.3
—
—
—
0
0
6
37
1.63
0.55
1.0
1.1
—
—
—
0
0
463
4522
1.14
0.54
57.0
25.5
7.78
6.84
e9/l
11.90
454
4397
9
134
0.67
0.52
1.2
1.1
—
—
—
0
0
30
368
0.80
0.51
2.3
1.5
—
—
—
0
0
9
64
1.41
0.51
1.0
1.1
—
—
—
0
0
12
84
1.44
0.49
1.9
1.3
—
—
—
0
0
462
4519
1.13
0.49
56.7
25.4
91.98
91.53
fl
1.17
457
4446
462
4520
1.13
0.48
58.4
25.8
37.46
39.72
%
11.10
457
4442
462
4520
1.13
0.48
56.8
25.4
4.17
4.42
e12/l
18.52
453
4393
462
4520
1.13
0.48
56.6
25.5
244.32
240.53
e9/l
0.55
453
4412
462
4520
1.13
0.48
56.6
25.3
30.24
30.37
pg
0.79
457
4446
462
4521
1.13
0.47
57.4
25.6
125.23
133.16
g/l
21.67
457
4446
6
92
0.65
0.42
1.7
1.4
—
—
—
0
0
34
286
1.20
0.42
1.1
1.2
—
—
—
0
0
5
33
1.52
0.41
1.6
1.6
49.00
97.36
ng/l
—
5
33
25
204
1.24
0.41
2.7
3.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
7.82
—
0
15
0
17
0.00
0.40
0.0
1.6
—
89222.25
—
0
12
5
34
1.47
0.40
2.2
2.2
—
—
—
0
0
42
481
0.86
0.37
1.5
1.3
—
—
—
0
0
8
114
0.70
0.37
1.0
1.2
—
2.15
—
0
13
6
42
1.43
0.35
2.8
2.4
—
—
—
0
0
118
1099
1.09
0.35
1.4
1.3
—
—
—
0
0
16
200
0.79
0.35
1.3
1.3
—
—
—
0
0
10
73
1.38
0.34
1.3
1.1
—
—
—
0
0
12
91
1.33
0.34
2.2
1.5
—
—
—
0
0
22
183
1.21
0.32
1.5
1.7
—
—
—
0
0
12
92
1.31
0.32
1.7
1.9
—
—
—
0
0
30
262
1.15
0.27
1.4
1.5
—
—
—
0
0
43
389
1.11
0.24
1.4
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
15
127
1.19
0.19
4.5
3.4
1.61
1.77
index
—
9
75
11
133
0.82
0.19
13.5
11.9
—
—
—
0
0
444
4390
1.06
0.18
16.5
11.9
29.09
24.96
u/l
0.78
432
4226
21
185
1.14
0.18
2.5
3.2
3011.06
6832.36
u/ml
0.26
16
153
7
61
1.15
0.17
1.3
1.4
—
—
—
0
0
14
121
1.16
0.15
1.9
1.5
4904.13
11364.73
e6/l
—
8
86
38
355
1.08
0.13
3.8
2.5
12.15
13.53
nmol/l
0.49
33
321
392
3961
0.97
0.12
9.9
6.4
43.32
39.65
mmol/mol
7.51
368
3625
174
1702
1.03
0.11
4.3
6.0
2.11
3.04
ug/l
1.85
158
1502
21
229
0.91
0.11
2.2
1.3
607.48
245.55
u/ml
0.48
21
212
15
167
0.90
0.11
1.7
1.8
2.22
8.51
iu/ml
—
6
46
22
239
0.92
0.10
1.3
1.4
—
—
—
0
0
13
116
1.12
0.09
1.5
1.9
49.08
41.95
nmol/l
0.43
13
111
5
48
1.04
0.09
5.6
2.9
7.80
11.75
index
—
5
28
26
244
1.07
0.08
2.0
2.5
—
22.48
—
0
13
23
219
1.05
0.04
1.1
1.3
—
46.32
—
0
18
26
250
1.04
0.03
1.2
1.3
—
—
—
0
0
303
3020
1.01
0.01
5.9
4.3
—
0.27
—
0
11
405
4051
1.00
0.00
6.2
5.3
6.43
5.99
mmol/l
6.43
361
3617
5
56
0.89
0.00
1.4
2.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.42
—
0
5
5
54
0.93
-0.00
1.0
1.2
—
91.26
—
0
5
0
5
0.00
-0.00
0.0
8.6
—
0.49
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
104.00
—
0
8
0
8
0.00
-0.00
0.0
1.0
—
0.02
—
0
8
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint E4_HYPEROSMHNAT and mortality.

Females

Parameter HR [95% CI] p-value
E4_HYPEROSMHNAT 2.976 [2.48, 3.57] < 0.001
Birth year 0.994 [0.98, 1.0] 0.197

During the follow-up period (1.1.1998 — 31.12.2019), 1646 out of 2715 females with E4_HYPEROSMHNAT died.

Males

Parameter HR [95% CI] p-value
E4_HYPEROSMHNAT 4.461 [3.18, 6.26] < 0.001
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 1063 out of 1820 males with E4_HYPEROSMHNAT died.

Mortality risk

Mortality risk for people of age

years, who have E4_HYPEROSMHNAT.

N-year risk Females Males
1 0.292% 0.98%
5 1.729% 5.517%
10 4.226% 12.168%
15 8.068% 21.54%
20 13.518% 34.209%

Relationships between endpoints

↥

Index endpoint: E4_HYPEROSMHNAT – Hyperosmolality and hypernatraemia

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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