No definition available.
Congenital hypothyroidism without goiter
E4_CONGENITAL_HYPOTHYROIDISM_WITHOUT_GOITER
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
203 |
4. Check minimum number of eventsNone |
203 |
5. Include endpointsNone |
203 |
6. Filter based on genotype QC (FinnGen only) |
183 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Similar endpoints
↥List of similar endpoints to
Congenital hypothyroidism without goiter
based on the number of shared cases.
Similar with more cases:
- Congenital iodine-deficiency syndrome/hypothyroidism
- Hypothyroidism (congenital or acquired)
- Hypothyreosis and Thyroxine purchase for inclusion criteria
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded (different definition than used in FinnGen).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 183 | 159 | 24 |
| Unadjusted period prevalence (%) | 0.05 | 0.06 | 0.01 |
| Median age at first event (years) | 37.63 | 36.09 | 47.80 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 194
- Matched controls
- 1940
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E03.1
ICD-10 Finland
Congenital hypothyroidism without goitre
+∞
280.8
194
*
H03AA01
ATC
levothyroxine sodium; systemic
161.2
121.4
188
315
104
Kela drug reimbursment
Thyroid insufficiency
28.4
120.1
100
70
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
22.5
111.9
134
175
E03.89
ICD-10 Finland
Other specified hypothyroidism
15.5
46.0
44
36
T86
ICPC
Hypothyroidism/myxoedema
12.3
38.9
43
44
E03
ICD-10 Finland
Other hypothyroidism
7.4
26.5
44
74
E03.0
ICD-10 Finland
Congenital hypothyroidism with diffuse goitre
49.3
15.3
18
*
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
12.9
15.3
27
24
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
14.2
14.9
25
20
A10AE04
ATC
insulin glargine; parenteral
3.6
7.6
26
79
24399
ICD-8 Finland
Cretinism of congenital origin
+∞
7.3
7
*
E03.8
ICD-10 Finland
Other specified hypothyroidism
31.3
7.2
9
*
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
4.7
7.1
17
39
A29
ICPC
General symptom/complaint other
2.8
7.0
40
165
SPAT1263
SPAT
Sampling
2.2
6.4
97
615
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
6.1
6.3
16
28
E03.3
ICD-10 Finland
Postinfectious hypothyroidism
+∞
6.3
6
*
SPAT1254
SPAT
Administration of medicine
2.6
6.2
41
182
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
185
1413
7.66
14.20
14.5
4.8
16.51
14.60
pmol/l
15.45
176
1300
186
1614
4.69
6.63
16.3
5.7
2.08
1.85
mu/l
0.93
177
1503
86
555
1.99
5.11
1.4
1.6
0.53
2.09
u/ml
2.16
23
136
84
562
1.87
4.31
3.4
3.3
29.09
27.89
u/l
0.18
79
539
114
840
1.87
4.30
3.4
2.9
75.62
76.38
nmol/l
0.09
105
762
46
255
2.05
4.06
2.2
1.7
—
—
—
0
0
72
479
1.80
3.64
1.9
2.2
156.96
166.10
u/l
0.06
67
460
17
64
2.82
3.50
2.1
2.1
1.80
5.89
iu/l
—
9
26
41
233
1.96
3.35
2.1
1.6
1380.01
1243.13
nmol/l
0.38
33
170
6
7
8.79
3.28
1.7
5.1
258.17
198.71
u/l
—
6
7
78
546
1.72
3.23
5.1
4.0
34.72
31.55
ng/l
0.09
47
351
109
837
1.69
3.19
10.6
7.3
1.21
1.22
mmol/l
0.87
93
720
72
498
1.71
3.09
2.4
2.7
2.81
2.67
mg/l
0.24
66
426
123
983
1.69
3.03
3.8
3.3
71.33
74.05
ug/l
0.10
117
924
45
286
1.75
2.56
6.0
3.5
23.12
516.34
ng/l
2.62
33
185
15
63
2.50
2.53
5.7
3.8
23.96
23.68
mmol/l
0.11
15
63
7
16
4.50
2.50
1.0
1.3
—
—
—
0
0
92
714
1.55
2.33
2.1
1.9
97.75
95.94
pmol/l
0.12
48
353
10
34
3.04
2.32
1.4
1.7
—
—
—
0
0
61
432
1.60
2.29
4.2
4.0
1595.34
1125.67
ng/l
0.33
53
360
31
182
1.84
2.29
2.1
1.6
—
—
—
0
0
5
9
5.67
2.22
1.2
1.2
—
—
—
0
0
96
759
1.52
2.20
9.4
7.4
1.21
1.22
mmol/l
0.61
91
704
26
147
1.89
2.15
4.8
5.7
5.06
5.04
kpa
0.06
26
141
142
1232
1.57
2.04
10.2
7.9
92.72
80.92
u/l
0.57
135
1159
16
77
2.17
2.03
1.6
1.6
—
—
—
0
0
11
48
2.37
1.74
1.2
2.0
3.82
3.66
mmol/l
0.16
11
43
56
412
1.50
1.74
3.6
4.2
1.02
1.02
kg/l
0.12
40
255
28
175
1.70
1.69
1.4
1.3
243.09
133.06
u/ml
0.43
11
68
159
1439
1.58
1.66
7.8
5.7
39.58
38.23
mmol/mol
0.78
146
1348
65
505
1.43
1.51
3.8
4.5
0.00
0.01
estimate
0.50
20
192
144
1289
1.45
1.47
4.2
3.9
—
—
—
0
0
63
489
1.43
1.47
1.6
1.6
19.91
22.69
nmol/l
0.88
56
406
12
60
2.07
1.41
3.1
2.2
—
—
—
0
0
21
129
1.70
1.36
1.8
1.5
—
—
—
0
0
10
47
2.19
1.36
1.6
2.0
133.90
126.75
g/l
—
10
36
110
948
1.37
1.35
3.7
4.3
58.70
7.92
estimate
0.40
20
205
21
130
1.69
1.33
4.5
3.1
0.27
0.80
e6/l
0.36
21
125
111
960
1.37
1.32
3.8
4.4
0.00
0.00
estimate
-0.00
20
194
6
24
2.55
1.31
1.0
1.1
—
—
—
0
0
6
24
2.55
1.31
1.0
1.1
—
—
—
0
0
6
25
2.44
1.25
1.2
1.4
—
—
—
0
0
11
56
2.02
1.24
3.2
2.0
—
—
—
0
0
109
946
1.35
1.24
3.7
4.2
0.00
0.00
estimate
-0.00
18
201
26
175
1.56
1.20
1.8
1.6
—
—
—
0
0
23
151
1.59
1.18
10.0
8.4
9.82
13.01
kpa
4.99
23
145
23
151
1.59
1.18
10.0
8.4
5.50
5.18
kpa
0.95
23
144
51
396
1.39
1.17
1.7
2.1
0.62
0.94
mg/l
1.38
39
296
10
51
2.01
1.13
1.2
1.3
—
—
—
0
0
9
46
2.00
1.05
1.2
2.1
3.11
17.91
e6/l
—
9
33
20
131
1.59
1.05
5.3
3.6
1.22
1.23
mmol/l
0.20
20
112
9
47
1.96
1.03
1.2
2.1
336.44
322.75
e6/l
—
9
36
7
36
1.98
0.98
3.9
2.2
9.74
5.85
pmol/l
—
7
36
18
117
1.59
0.98
1.3
1.6
—
—
—
0
0
7
37
1.92
0.95
3.3
2.6
—
—
—
0
0
130
1182
1.30
0.94
6.3
5.1
18.33
132.82
e6/l
—
6
17
18
119
1.57
0.92
1.2
2.6
67.26
66.31
g/l
0.27
18
110
53
432
1.31
0.88
5.7
3.8
10.82
6.81
mg/mmol
0.23
35
263
117
1055
1.27
0.88
8.3
9.8
3.76
3.96
e9/l
0.56
103
920
11
65
1.73
0.84
1.6
1.9
1.13
1.45
g/l
0.65
11
58
80
694
1.26
0.82
3.5
4.1
0.00
0.02
estimate
0.50
15
167
46
374
1.30
0.78
3.6
3.4
319.17
320.20
umol/l
0.02
40
337
11
67
1.68
0.77
2.2
1.5
—
—
—
0
0
112
1019
1.23
0.72
6.9
5.2
6.73
6.38
mmol/l
0.82
106
933
20
144
1.43
0.71
3.7
3.9
4.28
56.54
ug/l
0.54
13
115
5
26
1.95
0.71
1.2
1.3
—
—
—
0
0
21
153
1.42
0.70
1.5
1.2
131.83
417.31
u/ml
0.88
21
139
7
117
0.58
0.70
1.7
1.5
—
—
—
0
0
69
598
1.24
0.70
2.7
3.0
2.34
2.37
mmol/l
1.14
63
539
162
1542
1.31
0.67
5.8
4.5
5.91
5.72
mmol/l
0.79
151
1414
7
44
1.61
0.66
1.0
1.1
—
—
—
0
0
137
1281
1.24
0.65
5.5
4.8
10.83
10.30
mm/h
0.21
129
1183
153
1448
1.27
0.65
4.7
3.9
1.23
1.20
mmol/l
0.29
142
1321
8
49
1.66
0.63
1.4
1.5
—
—
—
0
0
5
30
1.68
0.62
1.2
1.2
—
—
—
0
0
5
30
1.68
0.62
1.6
1.6
5.80
7.29
mmol/l
—
5
25
5
30
1.68
0.62
1.2
1.5
—
—
—
0
0
8
51
1.59
0.61
1.1
1.3
—
—
—
0
0
8
52
1.56
0.60
1.3
1.2
—
0.88
—
0
5
8
125
0.62
0.56
1.8
3.1
11.41
42.42
u/ml
—
8
119
6
38
1.60
0.55
1.2
1.3
—
—
—
0
0
6
38
1.60
0.55
1.3
2.4
16.60
15.87
%
—
6
38
163
1564
1.26
0.53
6.1
5.2
2.62
2.72
mmol/l
0.80
149
1452
6
40
1.52
0.52
1.7
2.1
—
—
—
0
0
6
40
1.52
0.52
1.2
1.2
—
1.53
—
0
9
158
1513
1.24
0.51
20.1
13.9
89.05
87.33
ml/min/173m2
0.39
140
1359
161
1548
1.24
0.48
5.6
4.7
4.53
4.65
mmol/l
0.90
150
1439
7
49
1.44
0.46
1.1
1.4
—
—
—
0
0
160
1539
1.23
0.46
5.5
4.6
1.45
1.53
mmol/l
1.50
147
1422
21
166
1.30
0.45
11.0
5.4
—
—
—
0
0
10
140
0.70
0.45
1.0
1.0
—
—
—
0
0
32
377
0.82
0.43
1.8
2.3
—
—
—
0
0
19
150
1.30
0.42
5.9
3.6
—
—
—
0
0
0
15
0.00
0.41
0.0
4.3
—
—
—
0
0
42
365
1.19
0.41
1.5
1.3
15.47
32.23
iu/ml
1.51
15
104
60
538
1.17
0.41
3.3
3.5
0.00
0.01
estimate
0.50
13
163
0
17
0.00
0.41
0.0
1.4
—
—
—
0
0
11
148
0.73
0.40
2.1
1.5
—
—
—
0
0
5
35
1.44
0.39
1.4
1.2
—
—
—
0
0
5
35
1.44
0.39
1.0
1.3
—
—
—
0
0
5
77
0.64
0.36
2.0
1.3
—
—
—
0
0
6
42
1.44
0.36
2.7
1.8
—
—
—
0
0
10
73
1.39
0.35
1.7
1.6
45.57
51.93
ug/l
—
10
73
14
109
1.31
0.34
1.1
1.3
—
—
—
0
0
30
347
0.84
0.34
1.8
2.2
—
—
—
0
0
18
146
1.26
0.33
9.1
5.1
118.94
69.58
ng/l
0.96
18
133
36
408
0.86
0.32
1.9
1.5
—
—
—
0
0
175
1712
1.23
0.31
21.4
14.4
18.36
21.35
mg/l
0.79
144
1352
13
102
1.29
0.31
3.6
5.1
21.50
23.35
%
—
5
42
18
148
1.24
0.30
2.7
2.4
298.40
5616.25
u/l
—
5
55
8
64
1.26
0.28
1.1
1.4
—
—
—
0
0
21
178
1.20
0.27
2.0
2.6
35.79
27.94
u/l
0.50
14
149
12
95
1.28
0.27
1.7
1.7
—
—
—
0
0
179
1760
1.22
0.25
25.9
17.2
75.25
68.59
umol/l
0.73
174
1725
9
75
1.21
0.25
1.8
2.0
—
—
—
0
0
18
211
0.84
0.24
5.1
5.9
0.94
1.60
mmol/l
0.34
18
175
146
1499
0.89
0.23
24.0
18.0
13.48
13.44
%
0.15
146
1488
5
38
1.32
0.23
1.6
1.1
—
—
—
0
0
5
42
1.20
0.21
1.4
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
114.85
—
0
11
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
47.45
—
0
10
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
10
80
1.26
0.21
1.3
1.3
—
—
—
0
0
65
614
1.09
0.18
4.0
3.7
—
—
—
0
0
7
58
1.21
0.18
1.0
1.7
—
—
—
0
0
7
61
1.15
0.17
1.1
1.1
—
—
—
0
0
7
61
1.15
0.17
1.1
1.1
—
—
—
0
0
10
83
1.22
0.16
1.8
1.8
—
—
—
0
0
9
78
1.16
0.15
1.2
1.2
—
5.46
—
0
11
86
831
1.06
0.13
2.9
2.8
—
—
estimate
—
0
0
33
353
0.92
0.12
1.5
1.3
1.11
10.04
u/ml
2.61
11
132
51
535
0.94
0.12
2.0
1.9
—
—
—
0
0
30
321
0.92
0.11
2.9
3.0
0.85
0.76
e6/l
0.12
14
168
5
44
1.14
0.10
1.4
2.4
0.00
0.00
g/l
—
5
44
20
186
1.08
0.07
4.9
4.5
32.60
33.06
%
—
10
114
8
78
1.03
0.07
2.4
1.5
—
—
—
0
0
42
436
0.95
0.06
2.3
2.3
—
—
—
0
0
31
296
1.06
0.06
2.7
3.3
4.31
3.05
e6/l
0.43
15
144
22
210
1.05
0.04
2.0
4.1
6.09
5.83
umol/l
0.09
22
181
19
199
0.95
0.03
2.3
2.1
—
—
—
0
0
51
518
0.98
0.01
3.6
3.5
0.16
0.35
e6/l
0.82
37
372
68
688
0.98
0.01
2.3
1.9
1.17
1.29
mmol/l
0.78
62
582
24
244
0.98
0.00
2.3
2.2
—
—
—
0
0
15
149
1.01
0.00
13.7
8.2
10.03
7.68
mmol/l
0.56
15
141
16
163
0.98
0.00
9.2
9.5
25.78
25.28
mmol/l
0.21
16
163
22
215
1.03
0.00
9.8
6.7
103.95
104.41
mmol/l
0.17
22
215
12
115
1.05
0.00
3.3
3.0
84.17
67.17
ml/min/173m2
—
6
48
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
5
52
0.96
-0.00
1.6
1.2
—
69.17
—
0
6
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
92.83
—
0
6
0
5
0.00
-0.00
0.0
9.2
—
—
—
0
0
6
67
0.89
-0.00
1.7
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
9
89
1.01
-0.00
1.3
5.2
1.59
1.25
%
—
9
89
0
6
0.00
-0.00
0.0
1.2
—
39.50
—
0
6
0
5
0.00
-0.00
0.0
6.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.7
—
—
—
0
0
5
52
0.96
-0.00
1.2
1.1
—
19.37
—
0
13
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.25
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.6
—
—
—
0
0
8
81
0.99
-0.00
2.6
5.1
59.38
47.07
%
—
8
81
186
1857
1.04
-0.00
32.3
21.8
4.45
4.44
e12/l
0.15
181
1814
7
79
0.88
-0.00
1.4
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
16.42
—
0
9
0
9
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥This endpoint is excluded (different definition than used in FinnGen).
Relationships between endpoints
↥Index endpoint: E4_CONGENITAL_HYPOTHYROIDISM_WITHOUT_GOITER – Congenital hypothyroidism without goiter
GWS hits: -
This endpoint is excluded (different definition than used in FinnGen).