This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Dry age-related macular degeneration (includes geographic atrophy), under 50 years
DRY_AMD_EARLY
No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersPre-conditions: EVENT_AGE<50 Registry filters:
2 out of 7 registries used, show all original rules. |
183 |
4. Check minimum number of eventsNone |
183 |
5. Include endpointsNone |
183 |
6. Filter based on genotype QC (FinnGen only) |
158 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF12
- Parent code in ICD-10
- H35
- Name in latin
- Degeneratio maculae senilis atrophica
Similar endpoints
↥List of similar endpoints to
Dry age-related macular degeneration (includes geographic atrophy), under 50 years
based on the number of shared cases.
Similar with more cases:
- Degeneration of macula and posterior pole
- Other retinal disorders
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 158 | 90 | 68 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 46.01 | 46.15 | 45.84 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 164
- Matched controls
- 1640
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
3716.1
204.1
157
9
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
56.1
33.6
39
9
XCW99
NOMESCO Finland
Other investigative procedure of eye
8.4
31.2
49
79
XCK10
NOMESCO Finland
Photography of fundus of eye
8.9
31.1
46
69
H35.5
ICD-10 Finland
Hereditary retinal dystrophy
+∞
20.2
19
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
8.0
17.1
25
36
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.4
16.7
56
174
H35.7
ICD-10 Finland
Separation of retinal layers
28.0
16.5
22
9
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
33.4
14.2
18
6
XCK00
NOMESCO Finland
Perimetry
6.7
14.0
24
41
H35.9
ICD-10 Finland
Retinal disorder, unspecified
75.9
12.8
14
*
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
11.9
11.7
21
20
XCD20
NOMESCO Finland
Photoangiography of eye
22.0
11.4
16
8
ZXA10
NOMESCO Finland
Bilateral
3.6
10.9
43
146
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
4.4
10.8
30
79
S01EC01
ATC
acetazolamide; systemic
20.4
10.5
15
8
CJB10
NOMESCO Finland
Laser discission of secondary cataract
9.2
9.4
19
23
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
3.3
9.1
41
150
Z96.1
ICD-10 Finland
Presence of intraocular lens
4.1
8.7
26
72
3625A
ICD-9 Finland
Other retinal disorders, Degeneration of macula and posterior pole[DEGENERATIO MACULAE NONEXSUDATIVA]
+∞
8.4
8
*
CKC10
NOMESCO Finland
Local photocoagulation of retina
14.3
7.5
12
9
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
83.7
7.5
8
*
Z3229
NOMESCO Finland
Other healthcare associate professional
4.0
7.0
21
58
H26.4
ICD-10 Finland
After-cataract
5.5
6.4
18
36
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.0
6.1
30
114
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
89
584
2.15
5.43
6.6
6.1
1.22
1.21
mmol/l
0.71
82
549
88
580
2.12
5.25
5.6
5.2
35.64
36.70
g/l
1.10
80
560
53
296
2.17
4.78
2.8
2.0
2.53
2.86
mg/l
0.65
43
261
11
19
6.12
4.52
2.6
2.8
8.93
5.52
pmol/l
0.56
11
19
93
650
2.00
4.48
9.1
7.3
1.22
1.21
mmol/l
0.39
72
579
59
353
2.05
4.39
3.5
2.8
0.08
0.31
e6/l
2.28
46
244
68
431
1.99
4.30
5.8
3.8
7.65
5.78
mg/mmol
0.23
44
267
88
610
1.96
4.28
3.0
2.5
75.00
75.76
nmol/l
0.09
83
572
11
22
5.28
4.08
2.5
4.1
5.24
5.16
kpa
0.11
11
22
22
90
2.67
3.91
4.5
9.9
23.60
25.01
mmol/l
0.63
22
90
82
567
1.89
3.91
2.9
3.6
26.66
30.02
u/l
0.99
74
545
69
457
1.88
3.71
3.8
3.8
2.35
2.35
mmol/l
0.04
64
428
31
161
2.14
3.27
2.2
1.6
1366.42
1297.87
nmol/l
0.15
23
127
6
8
7.73
3.08
1.3
1.3
1.88
1.70
mmol/l
—
6
8
53
340
1.83
3.06
2.3
3.0
422.42
661.58
ng/l
0.94
40
283
12
37
3.42
3.00
2.2
1.5
—
—
—
0
0
58
393
1.74
2.74
4.7
3.4
0.00
0.00
estimate
-0.00
26
143
97
761
1.67
2.62
6.9
6.7
10.76
10.96
umol/l
0.08
92
737
12
45
2.80
2.51
1.2
1.4
365.00
302.73
ug/g
—
5
29
14
58
2.55
2.44
2.0
1.4
—
—
—
0
0
33
196
1.86
2.39
2.6
2.7
4.82
6.20
umol/l
0.71
28
177
5
8
6.40
2.39
4.8
5.4
484.20
622.50
u/ml
—
5
8
101
816
1.62
2.30
7.2
5.0
6.75
6.61
mmol/l
0.29
96
779
130
1131
1.72
2.10
6.1
4.4
14.85
14.58
pmol/l
0.66
121
1065
21
114
1.97
1.98
4.6
2.9
—
—
—
0
0
8
27
3.06
1.96
1.1
1.2
—
—
—
0
0
127
1108
1.65
1.92
10.4
8.2
75.28
78.22
u/l
0.42
121
1059
29
183
1.71
1.72
7.9
7.4
104.97
104.45
mmol/l
0.17
29
183
66
509
1.50
1.70
4.3
3.1
32.89
35.58
ng/l
0.07
48
307
16
84
2.00
1.66
11.2
10.3
15.91
16.40
%
0.29
16
78
9
38
2.45
1.48
2.1
2.0
25.21
24.88
mmol/l
—
9
38
7
28
2.56
1.47
1.3
1.3
—
—
—
0
0
47
347
1.50
1.47
1.8
1.6
22.58
21.28
nmol/l
0.20
41
310
91
764
1.43
1.44
5.1
3.4
0.00
0.00
estimate
-0.00
28
148
11
53
2.15
1.42
1.3
1.4
—
—
—
0
0
153
1434
2.00
1.42
4.9
4.3
1.42
1.32
mmol/l
0.78
143
1359
100
856
1.43
1.41
10.2
11.1
3.74
4.00
e9/l
0.84
92
740
23
146
1.67
1.35
8.8
9.7
4.75
5.16
kpa
1.27
23
135
23
146
1.67
1.35
8.8
9.7
13.08
13.14
kpa
0.02
23
137
36
256
1.52
1.33
4.9
3.8
18.15
813.04
ng/l
1.90
26
178
21
131
1.69
1.31
9.2
10.2
124.24
124.85
g/l
0.05
21
125
81
675
1.40
1.30
2.3
1.9
1.59
1.44
mmol/l
0.68
66
588
122
1093
1.45
1.27
5.9
4.2
12.11
9.28
mm/h
1.77
113
1041
6
25
2.45
1.25
2.2
1.6
—
—
—
0
0
43
322
1.45
1.24
5.2
3.5
1.02
1.02
kg/l
0.61
36
211
34
243
1.50
1.23
2.6
1.6
482.24
450.09
pmol/l
0.15
25
219
69
564
1.39
1.22
2.4
1.9
96.03
98.54
pmol/l
0.14
37
290
15
243
0.58
1.20
2.1
2.2
3.48
3.48
ratio
—
10
198
88
752
1.37
1.17
5.1
3.4
0.00
0.00
estimate
-0.00
27
146
33
239
1.48
1.12
3.3
2.8
2.43
2.43
mmol/l
0.04
27
217
48
376
1.39
1.08
1.5
1.4
0.45
1.70
u/ml
1.47
13
119
87
763
1.30
0.89
5.3
3.5
0.00
0.02
estimate
0.50
24
139
69
587
1.30
0.88
5.2
3.2
0.00
0.01
estimate
0.50
24
123
39
308
1.35
0.83
1.3
1.3
25.97
8.72
u/ml
0.43
15
123
41
331
1.32
0.75
1.7
1.7
0.92
1.06
mg/l
0.14
32
258
12
76
1.62
0.74
3.5
2.3
21.33
24.65
mmol/l
1.47
12
76
5
27
1.88
0.69
1.0
1.6
—
—
—
0
0
141
1340
1.37
0.68
7.5
5.2
1.96
1.87
mu/l
0.29
134
1266
12
176
0.66
0.66
1.4
2.0
—
—
—
0
0
30
374
0.76
0.66
3.6
3.9
17.92
20.97
%
0.44
11
140
17
121
1.45
0.65
1.6
1.3
65.39
151.87
u/ml
—
8
50
0
20
0.00
0.61
0.0
1.1
—
—
—
0
0
0
20
0.00
0.61
0.0
2.2
—
13.58
—
0
20
0
22
0.00
0.60
0.0
1.1
—
—
—
0
0
0
22
0.00
0.60
0.0
1.2
—
—
—
0
0
147
1413
1.39
0.58
6.1
4.5
6.12
5.85
mmol/l
1.42
135
1349
13
182
0.69
0.58
1.9
2.0
3.29
3.61
mmol/l
—
8
140
154
1493
1.52
0.56
6.2
5.1
4.78
4.82
mmol/l
0.18
147
1436
6
37
1.64
0.56
1.5
1.2
—
—
—
0
0
37
307
1.26
0.56
1.6
1.6
—
—
—
0
0
155
1507
1.52
0.54
6.8
5.5
2.86
2.87
mmol/l
0.06
147
1444
15
109
1.41
0.53
3.1
3.7
4.11
4.61
pmol/l
2.57
15
93
12
84
1.46
0.51
1.4
1.8
—
—
—
0
0
26
211
1.28
0.47
3.5
2.5
2.39
2.06
e6/l
0.08
15
96
45
390
1.21
0.46
2.3
2.4
320.90
336.15
umol/l
0.53
40
354
52
460
1.19
0.43
5.1
2.7
53.96
67.79
u/l
0.72
46
438
5
31
1.63
0.43
1.0
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
25
206
1.25
0.41
1.4
2.0
—
—
—
0
0
0
17
0.00
0.41
0.0
1.6
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
153
1492
1.38
0.41
6.2
5.0
1.44
1.47
mmol/l
0.34
146
1428
5
34
1.48
0.40
7.6
1.5
0.85
0.95
nmol/l
—
5
28
0
18
0.00
0.40
0.0
1.7
—
—
—
0
0
0
18
0.00
0.40
0.0
1.7
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.7
—
—
—
0
0
0
18
0.00
0.40
0.0
1.7
—
—
—
0
0
0
18
0.00
0.40
0.0
1.7
—
—
—
0
0
0
18
0.00
0.40
0.0
1.7
—
—
—
0
0
28
235
1.23
0.39
3.9
2.5
0.82
0.84
e6/l
0.03
17
120
50
447
1.17
0.37
5.3
2.7
0.00
0.02
estimate
0.80
23
115
15
118
1.30
0.35
1.9
2.1
47.43
74.13
ml/min/173m2
—
7
48
71
657
1.14
0.33
3.3
2.6
—
—
estimate
—
0
0
7
96
0.72
0.32
1.0
1.1
0.97
0.91
g/l
—
7
96
18
148
1.24
0.31
5.4
5.9
—
—
—
0
0
39
348
1.16
0.29
1.3
1.3
18.73
32.71
iu/ml
0.91
14
117
16
194
0.81
0.29
1.4
2.1
—
—
—
0
0
8
62
1.30
0.28
2.4
1.5
—
—
—
0
0
8
66
1.22
0.27
1.0
1.6
—
—
—
0
0
7
95
0.73
0.23
1.0
1.1
1.43
1.56
g/l
—
7
95
5
40
1.26
0.22
1.6
1.2
—
—
—
0
0
5
41
1.23
0.22
1.2
1.1
—
—
—
0
0
5
41
1.23
0.22
1.2
1.5
0.00
0.00
g/l
—
5
41
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
1.10
—
0
12
0
12
0.00
0.21
0.0
1.3
—
11.25
—
0
12
0
13
0.00
0.21
0.0
1.1
—
2.98
—
0
13
6
48
1.26
0.20
2.3
2.6
23.93
24.26
mmol/l
—
6
43
120
1167
1.11
0.19
3.4
3.4
44.13
46.50
u/l
0.20
112
1136
100
1034
0.92
0.18
3.0
3.4
—
—
—
0
0
145
1427
1.14
0.16
19.1
12.4
84.55
86.86
ml/min/173m2
0.75
137
1327
143
1450
0.89
0.13
21.2
13.5
21.66
21.00
mg/l
0.08
118
1150
5
46
1.09
0.09
1.4
1.2
—
—
—
0
0
6
58
1.04
0.08
1.3
1.4
—
—
—
0
0
27
256
1.07
0.06
1.1
1.5
—
—
—
0
0
45
466
0.95
0.06
5.5
4.2
1.43
1.63
ug/l
0.37
39
429
28
289
0.96
0.02
2.7
2.6
0.65
0.70
ug/l
0.19
19
151
16
152
1.06
0.02
1.3
1.9
—
—
—
0
0
17
163
1.05
0.01
1.2
1.9
—
—
—
0
0
12
126
0.95
0.00
1.6
1.5
—
—
—
0
0
34
335
1.02
0.00
2.9
2.1
—
—
—
0
0
5
52
0.96
0.00
1.2
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.2
—
156.20
—
0
5
7
77
0.91
-0.00
2.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
15.10
—
0
6
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
4.6
—
18.48
—
0
9
0
9
0.00
-0.00
0.0
2.6
—
98.33
—
0
9
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
7
76
0.92
-0.00
2.4
2.3
4.93
2.93
mg/l
—
7
58
0
9
0.00
-0.00
0.0
1.1
—
1316.44
—
0
9
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
9
0.00
-0.00
0.0
2.2
—
115.56
—
0
9
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
63.43
—
0
6
0
9
0.00
-0.00
0.0
1.1
—
110.00
—
0
9
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
8
0.00
-0.00
0.0
1.0
—
122.63
—
0
8
5
58
0.86
-0.00
1.2
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
7
79
0.88
-0.00
1.3
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: DRY_AMD_EARLY – Dry age-related macular degeneration (includes geographic atrophy), under 50 years
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).