Drug-induced osteoporosis

DRUGADVERS_OSTEOPO

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M81.4#

1 out of 7 registries used, show all original rules.

535

4. Check minimum number of events

None

535

5. Include endpoints

None

535

6. Filter based on genotype QC (FinnGen only)

477

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2113 1359 743
Only index persons 1899 1226 673
Unadjusted period prevalence (%)
Whole population 0.03 0.04 0.02
Only index persons 0.04 0.05 0.03
Median age at first event (years)
Whole population 64.57 67.51 59.16
Only index persons 63.70 66.76 58.12

-FinnGen-

Key figures

All Female Male
Number of individuals 477 325 152
Unadjusted period prevalence (%) 0.10 0.12 0.07
Median age at first event (years) 64.20 64.91 62.69

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
497
Matched controls
4970
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M81.4
ICD-10 Finland
Drug-induced osteoporosis
+∞
307.7
497
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
20.9
253.1
244
219
L04AX01
ATC
azathioprine; systemic
28.9
215.8
158
79
M05BA04
ATC
alendronic acid; oral
15.2
205.1
243
294
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
13.0
134.7
418
1434
318
Kela drug reimbursment
Teriparatide
81.3
130.6
70
10
M05BX04
ATC
denosumab; parenteral
11.3
127.5
161
202
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
67.7
126.7
70
12
M81.9
ICD-10 Finland
Osteoporosis, unspecified
12.7
118.6
132
138
H05AA02
ATC
teriparatide; parenteral
68.1
108.8
60
10
L01BA01
ATC
methotrexate; systemic
15.6
104.7
98
77
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
7.7
98.7
181
345
L04AA06
ATC
mycophenolic acid; systemic
24.2
96.2
71
34
H02AB06
ATC
prednisolone; systemic
8.8
88.3
418
1868
H02AB09
ATC
hydrocortisone; systemic
17.4
88.0
76
51
L04AX03
ATC
methotrexate; systemic
7.2
86.2
161
309
M05BA07
ATC
risedronic acid; oral
12.8
81.4
85
79
H02AB07
ATC
prednisone; oral
6.2
80.3
183
424
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
8.3
78.0
118
179
P01BA02
ATC
hydroxychloroquine; oral
6.4
66.3
133
269
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
7.0
64.8
114
202
L04AA01
ATC
[U] ciclosporin
30.5
62.8
42
15
ZX120
NOMESCO Finland
Intravenous
6.1
60.9
128
269
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
5.5
58.6
140
330
L95
ICPC
Osteoporosis
7.7
58.3
91
141
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
7.1
57.3
97
164
127
Kela drug reimbursment
Transplant complication
22.8
56.4
42
20
L04AD01
ATC
ciclosporin; systemic
17.8
56.3
47
29
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
10.8
56.0
64
67
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.9
54.7
377
1951
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
7.4
54.5
88
141
H02AB04
ATC
methylprednisolone; systemic
4.5
50.2
159
467
M05BB03
ATC
alendronic acid and colecalciferol; oral
10.6
48.6
56
59
TPH04
NOMESCO Finland
Cathetrisation of vein
4.0
47.8
208
765
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.8
46.8
225
883
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
12.2
46.4
48
43
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.6
43.2
249
1088
A07EC01
ATC
sulfasalazine; oral, rectal
5.3
41.5
96
216
M81.8
ICD-10 Finland
Other osteoporosis
16.1
41.2
36
24
J01MA12
ATC
levofloxacin; systemic
3.8
40.3
168
590
L04AA13
ATC
[U] leflunomide
10.1
39.8
47
51
UGC12
NOMESCO Finland
Flexible bronchoscopy
5.3
39.6
90
199
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.1
37.7
130
399
L04AB04
ATC
adalimumab; parenteral
11.1
37.4
41
40
K50.8
ICD-10 Finland
Other Crohn disease
12.8
37.2
37
31
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
8.2
36.7
51
68
L88
ICPC
Rheumatoid/seropositive arthritis
6.4
36.0
64
112
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
7.2
35.7
56
86
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.7
35.7
147
508
M05BA06
ATC
ibandronic acid; systemic
8.7
35.6
47
59
R03AK08
ATC
formoterol and beclometasone; inhalant
6.4
35.2
63
111
R03DA04
ATC
theophylline; systemic, rectal
6.1
35.1
66
122
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
6.5
34.9
61
105
XG410
NOMESCO Finland
Flow-volume spirometry
6.8
34.8
58
95
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.2
34.5
109
312
J45.0
ICD-10 Finland
Predominantly allergic asthma
4.5
34.5
98
259
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
3.4
34.0
170
662
J01MA14
ATC
moxifloxacin; systemic
4.4
33.4
98
265
TGC00
NOMESCO Finland
Bronchial lavation
7.7
33.2
49
70
J46
ICD-10 Finland
Status asthmaticus
8.8
33.0
43
53
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
8.1
32.8
46
62
A07EA06
ATC
budesonide; oral, local oral
6.6
32.7
56
94
K50.0
ICD-10 Finland
Crohn disease of small intestine
13.1
32.7
32
26
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.3
32.1
160
619
M80.0
ICD-10 Finland
Postmenopausal osteoporosis with pathological fracture
8.1
31.5
44
59
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.1
31.1
98
279
UJF32
NOMESCO Finland
Coloscopy
3.0
30.4
204
933
C03CA01
ATC
furosemide; systemic
3.0
30.3
224
1080
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
72.7
30.3
34
5
D86.0
ICD-10 Finland
Sarcoidosis of lung
12.7
30.1
30
25
J45.1
ICD-10 Finland
Nonallergic asthma
4.5
29.9
82
210
R50.9
ICD-10 Finland
Fever, unspecified
3.5
29.8
131
467
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
7.8
29.7
43
60
R03BB04
ATC
tiotropium bromide; inhalant
4.0
29.7
96
278
K50.9
ICD-10 Finland
Crohn disease, unspecified
11.7
29.6
31
28
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
4.3
28.7
83
221
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
5.7
28.6
57
111
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
3.9
28.0
97
294
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.9
27.4
191
883
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
7.4
27.1
41
60
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
6.4
26.1
45
76
A07EC02
ATC
mesalazine; oral, rectal
5.0
25.7
60
134
J45.9
ICD-10 Finland
Asthma, unspecified
2.9
25.3
157
677
J96.1
ICD-10 Finland
Chronic respiratory failure
9.4
25.3
31
35
GD1AD
NOMESCO Finland
Thorax CT examination
4.4
24.8
68
173
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
8.3
24.5
33
42
WZC30
NOMESCO Finland
Teaching
3.0
24.1
134
542
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
7.9
24.0
34
46
A41.9
ICD-10 Finland
Sepsis, unspecified
6.6
24.0
40
65
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.4
23.7
98
332
TDM10
NOMESCO Finland
Puncture of maxillary antrum
5.7
23.2
45
85
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
6.5
23.2
39
64
M81.0
ICD-10 Finland
Postmenopausal osteoporosis
5.7
22.9
45
86
J01MA02
ATC
ciprofloxacin; systemic
2.5
22.8
249
1409
NH3EA
NOMESCO Finland
Feet X-ray examination with load
7.9
22.7
32
43
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
4.6
22.5
57
136
NF1AA
NOMESCO Finland
Hip X-ray examination
3.5
22.3
86
278
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
27.9
21.6
29
11
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
3.6
21.3
78
244
WX882
NOMESCO Finland
High dependency care
6.5
20.9
35
57
N02AX02
ATC
tramadol; systemic, rectal
2.4
20.6
275
1681
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
3.4
20.5
85
287
UJF30
NOMESCO Finland
Ileoscopy through colon
3.2
20.5
92
327
A07AA02
ATC
nystatin; oral
4.0
20.4
63
175
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
8.8
20.3
26
31
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
4.1
19.9
59
159
R03BB01
ATC
ipratropium bromide; inhalant
5.1
19.8
43
90
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.7
19.6
129
565
N17.9
ICD-10 Finland
Acute renal failure, unspecified
5.2
19.1
41
85
WZC00
NOMESCO Finland
Treatment plan or consultation
2.3
19.0
233
1358
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.0
19.0
96
364
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
5.6
19.0
37
70
R03DC03
ATC
montelukast; oral
2.7
19.0
125
547
K51.8
ICD-10 Finland
Other ulcerative colitis
8.4
18.9
25
31
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
8.0
18.9
26
34
XW000
NOMESCO Finland
Bone marrow biopsy
4.9
18.8
43
94
J01FF01
ATC
clindamycin; systemic
2.4
18.5
181
954
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.2
18.3
84
301
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
6.6
18.2
30
48
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
4.8
18.1
42
93
R03AC13
ATC
formoterol; inhalant
4.0
18.0
55
151
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
7.9
18.0
25
33
B07.9
ICD-10 Finland
Verruca simplex
5.3
17.9
37
74
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.0
17.8
53
143
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
6.6
17.7
29
46
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
5.1
17.6
38
79
J47
ICD-10 Finland
Bronchiectasis
6.3
17.5
30
50
ZXE20
NOMESCO Finland
More than three and less than five hours
2.8
17.5
100
405
TK800
NOMESCO Finland
Hemodialysis
7.8
17.1
24
32
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.2
16.9
248
1537
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
4.1
16.9
48
125
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
15.8
16.8
27
18
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.7
16.7
107
459
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.3
16.6
68
227
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
4.1
16.5
48
127
JN3AD
NOMESCO Finland
Abdominal CT examination
2.8
16.5
96
392
Z01.8
ICD-10 Finland
Other specified special examinations
2.4
16.5
153
782
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
3.8
16.5
53
151
JN4BD
NOMESCO Finland
Extensive body CT
3.0
16.4
80
296
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
7.4
16.2
24
34
WX892
NOMESCO Finland
Monitored bed care
3.4
16.0
63
205
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.9
15.9
85
331
A02BC02
ATC
pantoprazole; systemic
2.5
15.8
387
2921
WW200
NOMESCO Finland
Immunization
5.6
15.6
30
56
A02BC05
ATC
esomeprazole; systemic
2.2
15.6
252
1607
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.6
15.6
108
481
R03DC01
ATC
zafirlukast; oral
6.7
15.5
25
39
WZA10
NOMESCO Finland
Extensive medical or dental certificate
11.8
15.5
28
25
Z2446
NOMESCO Finland
Social worker
3.5
15.4
57
178
A11CC03
ATC
alfacalcidol; systemic
7.0
15.4
24
36
N02AA05
ATC
oxycodone; systemic
2.4
15.4
130
634
R03BA02
ATC
budesonide; inhalant
2.4
15.4
129
627
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
16.7
15.4
24
15
M35.3
ICD-10 Finland
Polymyalgia rheumatica
4.1
15.4
44
115
D64.9
ICD-10 Finland
Anaemia, unspecified
3.0
15.3
77
290
M05BA01
ATC
etidronic acid; systemic
20.9
15.2
22
11
A02BC01
ATC
omeprazole; systemic
2.2
15.2
173
959
H26.3
ICD-10 Finland
Drug-induced cataract
14.6
15.2
25
18
L28
ICPC
Limited function/disability (L)
2.4
15.0
134
669
A02BC03
ATC
lansoprazole; oral
2.2
15.0
186
1065
R03AC12
ATC
salmeterol; inhalant
3.8
14.9
47
132
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
19.1
14.8
22
12
5BA08, ,
NOMESCO Finland
19.1
14.8
22
12
K51.5
ICD-10 Finland
Left sided colitis
5.3
14.8
30
59
XF400
NOMESCO Finland
ECG with 12 standard connections
2.5
14.7
105
473
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
11.4
14.7
27
25
M01CB01
ATC
sodium aurothiomalate; parenteral
11.4
14.7
27
25
J01FA06
ATC
roxithromycin; oral
2.1
14.4
237
1507
WX002
NOMESCO Finland
Sedation and analgesia
2.4
14.4
130
651
M05BX03
ATC
strontium ranelate; oral
23.1
14.3
20
9
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
4.9
14.2
32
69
L04AD02
ATC
tacrolimus; systemic
15.0
14.2
23
16
ZXD05
NOMESCO Finland
Urgent procedure
2.2
14.2
173
981
ZXA10
NOMESCO Finland
Bilateral
2.3
14.0
127
637
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.5
14.0
105
484
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.6
13.9
49
148
A01AB09
ATC
miconazole; local oral
3.0
13.8
68
253
TPH07
NOMESCO Finland
Cathetrisation of artery
2.7
13.7
84
350
R03BA08
ATC
ciclesonide; inhalant
2.9
13.6
68
255
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
5.1
13.5
29
60
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.6
13.4
46
137
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.8
13.4
75
299
NE1AA
NOMESCO Finland
Pelvis X-ray examination
2.9
13.3
66
246
UJD02
NOMESCO Finland
Gastroscopy
3.7
13.2
43
123
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
4.3
13.2
35
86
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.0
13.2
61
218
R03AC03
ATC
terbutaline; inhalant
2.5
13.2
95
429
S97
ICPC
Chronic ulcer skin
3.2
13.0
56
192
SPAT1254
SPAT
Administration of medicine
2.5
13.0
93
418
Z94.0
ICD-10 Finland
Kidney transplant status
19.7
13.0
19
10
R03AK03
ATC
[U] fenoterol and ipratropium bromide
3.7
12.9
43
125
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
3.1
12.9
58
204
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.5
12.9
91
406
UDH02
NOMESCO Finland
Rhinopharyngoscopy
3.1
12.9
56
193
SPAT1256
SPAT
Intramuscular and subcutaneous injection
2.0
12.9
237
1552
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
10.9
12.9
24
23
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
4.1
12.8
36
93
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
3.0
12.7
61
223
A46
ICD-10 Finland
Erysipelas
2.5
12.6
95
437
NF3AA
NOMESCO Finland
Femur X-ray examination
5.2
12.6
26
52
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.1
12.3
55
193
N03AX12
ATC
[U] gabapentin; oral
2.3
12.3
112
560
Z3226
NOMESCO Finland
Physiotherapist
2.2
12.3
120
618
D86.8
ICD-10 Finland
Sarcoidosis of other and combined sites
12.8
12.2
21
17
J45.8
ICD-10 Finland
Mixed asthma
4.3
12.0
31
75
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.0
11.9
191
1183
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.2
11.9
114
582
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.7
11.8
69
280
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
4.7
11.8
28
63
R06.0
ICD-10 Finland
Dyspnoea
2.0
11.8
172
1030
49300
ICD-8 Finland
Asthma, bronchiale
5.1
11.8
25
51
X59
ICD-10 Finland
Exposure to unspecified factor
2.2
11.8
120
627
ZX108
NOMESCO Finland
Inhalation
16.9
11.7
18
11
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
13.0
11.7
20
16
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
11.7
151
865
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
3.2
11.6
49
166
K50.1
ICD-10 Finland
Crohn disease of large intestine
9.6
11.6
23
25
SPAT1255
SPAT
Intravenous administration of medicine
3.3
11.6
46
150
J45
ICD-10 Finland
Asthma
2.6
11.5
72
303
E86
ICD-10 Finland
Volume depletion
5.6
11.4
22
41
R03BA05
ATC
fluticasone; inhalant
2.2
11.4
116
606
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
3.6
11.3
39
116
6BA02, ,
NOMESCO Finland
35.9
11.3
14
*
NDU20
NOMESCO Finland
Removal of internal fixation device from wrist or hand
5.7
11.3
21
38
N03AX16
ATC
[U] pregabalin
2.1
11.2
147
845
J82
ICD-10 Finland
Pulmonary eosinophilia, not elsewhere classified
25.7
11.2
15
6
UJF92
NOMESCO Finland
Capsular endoscopy
5.4
11.2
22
42
ZX112
NOMESCO Finland
Subcutaneous
4.5
11.1
27
62
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
5.9
11.1
20
35
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.9
11.1
288
2083
S22.0
ICD-10 Finland
Fracture of thoracic vertebra
5.0
11.1
24
50
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
4.8
11.1
25
54
NHG77
NOMESCO Finland
Arthroplasty of interphalangeal tarsal joint(s)
4.8
11.1
25
54
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
4.8
11.1
25
54
ZXE00
NOMESCO Finland
One hour or less
1.9
11.1
214
1406
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
5.6
11.0
21
39
C10AC01
ATC
colestyramine; oral
4.6
10.9
26
59
A28
ICPC
Limited function/disability NOS
2.1
10.8
117
624
AA1AD
NOMESCO Finland
CT of head and brain
2.0
10.8
175
1081
NK6PA
NOMESCO Finland
Measurement of bone density from one location with X-ray
28.7
10.8
14
5
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
2.9
10.8
54
202
R4190
NOMESCO Finland
Nutritional therapy
3.9
10.8
32
86
3AC01, ,
NOMESCO Finland
22.0
10.7
15
7
TPX10
NOMESCO Finland
Implantation of vascular injection port
4.4
10.7
27
64
R03AK07
ATC
formoterol and budesonide; inhalant
2.1
10.7
126
695
S32.0
ICD-10 Finland
Fracture of lumbar vertebra
3.7
10.7
34
96
N05CF01
ATC
zopiclone; oral
1.9
10.6
193
1238
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.9
10.6
32
87
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
5.0
10.6
23
48
B01AB05
ATC
enoxaparin; parenteral
1.9
10.6
190
1214
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
14.6
10.6
17
12
SPAT1262
SPAT
Handing over of treatment supplies
2.2
10.4
104
537
J01DB01
ATC
cefalexin; oral
2.4
10.4
427
3583
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.3
10.2
91
449
L01BB02
ATC
mercaptopurine; oral
9.4
10.1
20
22
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.6
10.1
33
95
A02BA03
ATC
famotidine; systemic
3.9
10.0
30
81
A01AB04
ATC
amphotericin B; local oral
3.2
10.0
40
131
XG466
NOMESCO Finland
Sleep oxymetry
4.3
10.0
26
63
JN4AD
NOMESCO Finland
Body CT examination
2.4
10.0
78
363
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
3.7
9.9
32
91
NG4AA
NOMESCO Finland
Lower leg X-ray examination
3.6
9.9
33
96
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
3.4
9.9
36
111
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
12.5
9.9
17
14
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
26.6
9.9
13
5
D86.9
ICD-10 Finland
Sarcoidosis, unspecified
10.9
9.9
18
17
L01AA01
ATC
cyclophosphamide; systemic
20.5
9.8
14
7
J01FA15
ATC
telithromycin; oral
2.5
9.8
65
280
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.9
9.8
197
1297
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
2.7
9.8
55
219
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
3.2
9.7
39
128
Z3231
NOMESCO Finland
Registered nurse
1.9
9.7
156
955
R60.0
ICD-10 Finland
Localized oedema
2.3
9.7
86
422
132
Kela drug reimbursment
Sarcoidosis
13.7
9.7
16
12
L04AB01
ATC
etanercept; parenteral
8.1
9.7
21
27
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
4.6
9.6
23
52
I26.0
ICD-10 Finland
Pulmonary embolism with mention of acute cor pulmonale
4.9
9.6
21
44
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
7.4
9.6
22
31
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
2.8
9.6
51
197
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.0
9.6
121
682
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.8
9.5
253
1813
E27.1
ICD-10 Finland
Primary adrenocortical insufficiency
101.9
9.4
10
*
L01BB01, ,
ATC
101.9
9.4
10
*
M08.4
ICD-10 Finland
Pauciarticular juvenile arthritis
+∞
9.4
9
*
N06AA09
ATC
amitriptyline; systemic
2.4
9.3
68
307
Y83.9
ICD-10 Finland
Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.8
9.3
28
76
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.6
9.3
57
237
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.5
9.2
63
276
R03AK11
ATC
formoterol and fluticasone; inhalant
4.1
9.2
25
63
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
4.7
9.1
21
46
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.9
9.1
163
1030
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.2
9.1
81
398
R03BA01
ATC
beclometasone; inhalant
2.2
9.1
83
412
TNX32
NOMESCO Finland
Custom moulded splint, unspecified region
3.3
9.1
35
112
71238
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides alia definita
10.3
9.1
17
17
XQ858
NOMESCO Finland
Oxygen partial pressure measurement
10.3
9.1
17
17
J05AB01
ATC
aciclovir; systemic
1.9
9.1
134
796
M08.0
ICD-10 Finland
Juvenile rheumatoid arthritis
37.4
9.0
11
*
SPAT1229
SPAT
Assessment of need for aid
2.7
9.0
50
197
R4110
NOMESCO Finland
Physiotherapy
1.9
9.0
163
1034
I50.9
ICD-10 Finland
Heart failure, unspecified
2.2
9.0
82
407
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
4.5
9.0
22
51
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.3
8.9
74
353
H26.2
ICD-10 Finland
Complicated cataract
8.8
8.9
18
21
D86.2
ICD-10 Finland
Sarcoidosis of lung with sarcoidosis of lymph nodes
9.7
8.8
17
18
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.1
8.8
90
467
ZXE10
NOMESCO Finland
More than one and less than three hours
1.8
8.8
199
1348
EBA10
NOMESCO Finland
Operative extraction of tooth
2.3
8.8
69
321
C03DA01
ATC
spironolactone; oral
2.2
8.8
79
390
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
3.5
8.8
30
89
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
2.9
8.8
43
159
NDG30
NOMESCO Finland
Fusion of wrist, total
14.4
8.7
14
10
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.8
8.7
46
177
SPAT1263
SPAT
Sampling
1.8
8.7
222
1558
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
3.4
8.6
32
100
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
3.4
8.6
31
95
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
16.6
8.6
13
8
B01AB04
ATC
dalteparin; parenteral
3.2
8.6
34
111
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
3.3
8.5
33
106
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
3.7
8.5
27
76
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
4.0
8.5
24
62
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
28.1
8.5
11
*
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
3.3
8.5
32
101
Z94.4
ICD-10 Finland
Liver transplant status
20.4
8.5
12
6
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
20.4
8.5
12
6
A03
ICPC
Fever
2.1
8.5
95
511
B01AA03
ATC
warfarin; systemic
2.0
8.4
99
541
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
91.6
8.4
9
*
NA6BG
NOMESCO Finland
Sacro-iliac joint MRI examination with high intensity magnet
8.1
8.4
18
23
UJG02
NOMESCO Finland
Proctoscopy
4.8
8.4
19
41
TQW11
NOMESCO Finland
Vacuum treatment of wound
4.8
8.4
19
41
4930A
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA SINE EXACERBATIONE]
13.1
8.4
14
11
297, ,
Kela drug reimbursment
+∞
8.4
8
*
R03DX09
ATC
mepolizumab; parenteral
+∞
8.4
8
*
3028
Kela drug reimbursment
Mepolizumab
+∞
8.4
8
*
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
3.6
8.3
28
82
A02BA02
ATC
ranitidine; systemic
1.9
8.3
114
659
XF600
NOMESCO Finland
Bloodpressure measurement
2.7
8.3
44
170
A03CA02
ATC
clidinium and psycholeptics; oral
2.9
8.2
40
147
ZXE40
NOMESCO Finland
More than seven and less than nine hours
4.5
8.2
20
46
R11
ICD-10 Finland
Nausea and vomiting
2.4
8.2
58
258
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
8.3
8.1
17
21
S18
ICPC
Laceration/cut
1.7
8.1
259
1922
A05AA02
ATC
ursodeoxycholic acid; oral
7.0
8.1
19
28
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
3.2
8.1
32
104
NDG74
NOMESCO Finland
Fusion of first IP joint
17.5
8.1
12
7
L76
ICPC
Fracture: other
3.7
8.1
26
74
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.4
8.0
55
241
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
3.2
8.0
31
100
N02AC04
ATC
dextropropoxyphene; oral
3.7
8.0
25
70
B02.9
ICD-10 Finland
Zoster without complication
2.6
7.9
49
204
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
2.8
7.9
40
150
G43.9
ICD-10 Finland
Migraine, unspecified
2.9
7.9
37
133
K92.1
ICD-10 Finland
Melaena
2.9
7.9
37
133
K51.0
ICD-10 Finland
Ulcerative (chronic) pancolitis
13.3
7.9
13
10
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
3.5
7.9
27
80
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
4.2
7.9
21
52
TAB00
NOMESCO Finland
Lumbar puncture
3.0
7.9
36
128
Y84
ICD-10 Finland
Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
11.0
7.8
14
13
WVA30, ,
SPAT
2.7
7.8
43
169
WVA20, ,
SPAT
3.3
7.8
30
96
SPAT1325
SPAT
Vaccination
1.7
7.8
182
1236
EBA15
NOMESCO Finland
Extraction of multiple teeth
3.6
7.8
26
76
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
2.9
7.8
36
129
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
6.1
7.8
20
34
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.5
7.7
52
226
K51.3
ICD-10 Finland
Ulcerative (chronic) rectosigmoiditis
4.6
7.7
18
40
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
3.7
7.7
24
67
J05AB11
ATC
valaciclovir; oral
2.0
7.7
96
536
UJF14
NOMESCO Finland
Enteroscopy of ileoanal anastomosis
18.7
7.6
11
6
E27.4
ICD-10 Finland
Other and unspecified adrenocortical insufficiency
18.7
7.6
11
6
Z94.1
ICD-10 Finland
Heart transplant status
18.7
7.6
11
6
Y83.1
ICD-10 Finland
Surgical operation with implant of artificial internal device as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
6.3
7.6
19
31
L99
ICPC
Musculoskeletal disease other
3.9
7.6
22
58
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
25.4
7.6
10
*
JF1DG
NOMESCO Finland
Small bowel very extensive MRI with with high intensity magnet
25.4
7.6
10
*
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
9.1
7.6
15
17
M80
ICD-10 Finland
Osteoporosis with pathological fracture
10.3
7.6
14
14
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.1
7.5
83
442
NH1AD
NOMESCO Finland
Ankle and foot CT
4.4
7.5
19
45
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.9
7.5
118
710
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.2
7.5
69
343
B03BA03
ATC
hydroxocobalamin; parenteral
2.9
7.5
35
126
E0000UV, ,
ATC
1.7
7.5
225
1633
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
2.9
7.5
36
132
A12AA04
ATC
calcium carbonate; oral
7.8
7.4
16
21
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
2.9
7.4
34
121
NFJ60
NOMESCO Finland
Internal fixation of fracture of other parts of femur with intramedullary nail
13.6
7.4
12
9
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.0
7.4
94
528
W17
ICD-10 Finland
Other fall from one level to another
3.5
7.3
25
74
B35.3
ICD-10 Finland
Tinea pedis
3.0
7.3
32
111
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
5.9
7.3
19
33
N05AB04
ATC
prochlorperazine; systemic, rectal
4.4
7.3
18
42
7140B
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SERONEGATIVA]
16.0
7.3
11
7
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
3.1
7.3
31
106
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
3.1
7.2
30
101
WX872
NOMESCO Finland
Intensive care
3.0
7.2
32
112
H26.4
ICD-10 Finland
After-cataract
2.2
7.2
66
328
CJB10
NOMESCO Finland
Laser discission of secondary cataract
2.3
7.2
56
260
R01AD08
ATC
fluticasone; nasal
1.8
7.2
150
983
M33.1
ICD-10 Finland
Other dermatomyositis
30.5
7.2
9
*
Z94.2
ICD-10 Finland
Lung transplant status
30.5
7.2
9
*
JJC00
NOMESCO Finland
Allogenic transplantation of liver
30.5
7.2
9
*
A03FA01
ATC
metoclopramide; systemic, rectal
1.8
7.2
130
817
SPAT1216
SPAT
Assessment of functional ability
2.0
7.2
89
495
H20.1
ICD-10 Finland
Chronic iridocyclitis
8.1
7.1
15
19
SPAT1231
SPAT
Assessment of adjustments needed in living environment
5.8
7.1
19
34
S72.2
ICD-10 Finland
Subtrochanteric fracture
12.3
7.1
12
10
ZZA00
NOMESCO Finland
Split skin graft
3.7
7.1
22
61
R81
ICPC
Pneumonia
3.3
7.1
27
86
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
3.0
7.1
32
113
ZXA05
NOMESCO Finland
Left side
1.8
7.1
136
869
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
4.3
7.1
18
43
N20.1
ICD-10 Finland
Calculus of ureter
3.5
7.1
24
71
RS221, ,
NOMESCO Finland
7.2
7.0
16
23
RD210, ,
NOMESCO Finland
6.5
7.0
17
27
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
6.5
7.0
17
27
N02AJ06
ATC
codeine and paracetamol; systemic
1.7
7.0
229
1691
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.6
7.0
42
173
ZYC01
NOMESCO Finland
Remote contact by phone
2.6
7.0
42
173
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.0
6.9
77
412
T93.2
ICD-10 Finland
Sequelae of other fractures of lower limb
11.1
6.8
12
11
4930B
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA CUM EXACERBATIONE]
9.5
6.8
13
14
A07EA02
ATC
hydrocortisone; rectal
4.4
6.8
17
40
105
Kela drug reimbursment
Adrenal cortical hypofunction
40.6
6.8
8
*
M30.1
ICD-10 Finland
Polyarteritis with lung involvement [Churg-Strauss]
40.6
6.8
8
*
M32
ICD-10 Finland
Systemic lupus erythematosus
40.6
6.8
8
*
E23.03
ICD-10 Finland
Lack of ACTH
40.6
6.8
8
*
M15.0
ICD-10 Finland
Primary generalized (osteo)arthrosis
3.1
6.8
28
94
H25.8
ICD-10 Finland
Other senile cataract
2.1
6.7
67
343
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
22.9
6.7
9
*
D47.2
ICD-10 Finland
Monoclonal gammopathy of undetermined significance (MGUS)
6.6
6.7
16
25
M84.3
ICD-10 Finland
Stress fracture, not elsewhere classified
5.6
6.7
18
33
J10.1
ICD-10 Finland
Influenza with other respiratory manifestations, seasonal influenza virus identified
6.0
6.7
17
29
D86.1
ICD-10 Finland
Sarcoidosis of lymph nodes
12.5
6.6
11
9
137
Kela drug reimbursment
Uraemia requiring dialysis
12.5
6.6
11
9
SPAT1153
SPAT
Removal of sutures
1.7
6.6
168
1158
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
2.8
6.6
32
118
RK110, ,
NOMESCO Finland
10.2
6.6
12
12
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
10.2
6.6
12
12
R5140
NOMESCO Finland
Monitoring the use of the aid
2.1
6.6
69
361
K83.0
ICD-10 Finland
Cholangitis
7.0
6.6
15
22
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
7.0
6.6
15
22
B99
ICD-10 Finland
Other and unspecified infectious diseases
5.5
6.5
18
34
Z2221
NOMESCO Finland
Medical doctor
1.7
6.5
140
921
WX402
NOMESCO Finland
General anaesthesia
1.8
6.5
122
773
ZXA00
NOMESCO Finland
Right side
1.7
6.5
145
965
F1246, ,
NOMESCO Finland
70.7
6.4
7
*
X58
ICD-10 Finland
Exposure to other specified factors
1.9
6.4
81
452
NG1DA
NOMESCO Finland
X-ray of knees
3.8
6.4
19
51
PAW37
NOMESCO Finland
Biopsy of temporal artery
14.5
6.4
10
7
L50.0
ICD-10 Finland
Allergic urticaria
3.7
6.4
20
56
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
3.3
6.4
24
76
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
3.3
6.4
24
76
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
8.3
6.4
13
16
A01AB10
ATC
natamycin; local oral
3.4
6.3
22
66
R03AC02
ATC
salbutamol; inhalant
1.6
6.3
285
2256
K74.3
ICD-10 Finland
Primary biliary cirrhosis
9.4
6.3
12
13
J93.1
ICD-10 Finland
Other spontaneous pneumothorax
18.3
6.3
9
5
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
3.2
6.3
25
82
JN4CD
NOMESCO Finland
Very extensive body CT
3.2
6.3
25
82
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
3.0
6.3
27
93
L04AA17
ATC
[U] adalimumab
27.0
6.2
8
*
A06AC01
ATC
ispaghula (psylla seeds); oral
1.7
6.2
152
1034
ND1AA
NOMESCO Finland
Wrist X-ray examination
2.3
6.2
48
222
R96
ICPC
Asthma
2.1
6.2
64
333
NA1BA
NOMESCO Finland
Cervical spine extensive X-ray examination without contrast
7.8
6.2
13
17
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.2
6.1
50
237
M31.3
ICD-10 Finland
Wegener granulomatosis
12.7
6.1
10
8
1370
FHL
Colonoscopy, whole colon
12.7
6.1
10
8
TGD04
NOMESCO Finland
Needle biopsy of the lungs in bronchoscopy
12.7
6.1
10
8
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.0
6.1
73
400
Z50.1
ICD-10 Finland
Other physical therapy
2.6
6.1
36
147
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
3.7
6.1
19
53
TQW40
NOMESCO Finland
Remowal of suture of skin
2.3
6.1
45
204
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.6
6.1
35
141
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
6.1
185
1329
B37.0
ICD-10 Finland
Candidal stomatitis
6.8
6.1
14
21
FB1AD
NOMESCO Finland
CT examination of arteria pulmonalis
3.3
6.1
22
68
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
2.8
6.0
30
112
M45
ICD-10 Finland
Ankylosing spondylitis
4.0
6.0
17
44
H65.3
ICD-10 Finland
Chronic mucoid otitis media
4.0
6.0
17
44
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.0
6.0
74
409
WX302
NOMESCO Finland
Thoracal epidural anesthesy
2.7
6.0
32
124

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
417
2145
6.86
66.39
5.6
2.5
84.94
78.43
nmol/l
5.85
400
1916
180
483
5.27
65.44
3.0
2.0
300.95
375.24
nmol/l
2.13
168
448
350
1586
5.08
64.59
18.1
6.1
—
—
—
0
0
154
385
5.35
60.37
6.0
3.0
9.74
10.62
g/l
1.29
148
354
158
415
5.12
58.22
7.1
4.5
0.61
0.69
%
0.18
77
126
426
2373
6.57
57.58
20.7
6.3
0.05
0.04
e9/l
0.78
407
2025
424
2362
6.41
57.03
20.8
6.3
0.68
0.58
e9/l
1.90
406
2014
429
2414
6.68
56.98
19.2
7.0
1.22
1.21
mmol/l
0.10
379
2084
160
432
4.99
56.89
7.7
4.4
0.86
1.06
%
0.45
80
136
404
2174
5.59
56.48
21.9
6.4
0.69
0.72
%
0.44
399
2030
153
404
5.03
55.80
7.9
4.5
0.06
0.14
%
0.99
71
107
403
2177
5.50
55.70
21.5
6.3
2.50
2.87
%
2.63
397
2037
403
2178
5.50
55.64
22.0
6.4
8.78
8.89
%
0.34
398
2043
204
680
4.39
55.06
3.6
2.4
20.53
22.11
%
0.85
194
637
424
2403
6.20
54.65
21.0
6.3
1.80
1.92
e9/l
0.69
407
2111
428
2447
6.40
54.50
21.5
6.5
0.18
0.19
e9/l
0.34
410
2128
218
779
4.20
53.16
3.7
2.4
11.36
12.86
umol/l
2.28
208
717
401
2210
5.22
52.55
17.1
6.1
1.21
1.21
mmol/l
0.05
390
2029
441
2629
7.01
52.14
24.2
9.8
4.76
4.00
e9/l
6.59
424
2287
206
728
4.12
50.62
3.7
2.4
2.27
2.32
g/l
0.69
195
674
149
420
4.64
49.54
8.2
4.9
0.03
0.22
%
1.16
64
104
196
684
4.08
48.74
3.5
2.0
—
—
—
0
0
134
360
4.73
47.15
1.6
2.5
—
—
—
0
0
123
310
4.94
46.81
3.1
1.7
1.21
1.39
g/l
0.49
113
282
147
429
4.45
46.44
2.0
3.1
64.01
67.18
g/l
4.72
138
400
283
1301
3.73
46.06
7.0
4.1
—
—
—
0
0
266
1176
3.72
45.97
3.7
2.2
3.28
3.00
mg/l
1.09
248
1003
210
798
3.83
45.65
7.2
3.1
0.80
0.81
mmol/l
1.42
204
755
374
2094
4.18
44.41
11.9
4.8
33.65
35.79
g/l
9.09
363
1963
294
1479
3.42
39.62
8.9
3.9
7.40
7.40
ph
0.29
235
1047
54
74
8.06
38.05
4.5
3.2
4.78
4.43
e9/l
0.35
54
74
154
555
3.57
34.96
2.7
1.7
—
—
—
0
0
149
529
3.59
34.57
5.3
2.6
1.87
1.83
%
0.17
135
472
160
601
3.45
33.91
2.7
1.4
—
—
—
0
0
51
75
7.46
33.73
2.2
1.8
0.54
0.77
g/l
0.56
39
62
40
45
9.58
32.88
2.3
1.4
5.79
7.10
g/l
0.72
29
35
40
45
9.58
32.88
2.3
1.4
2.43
2.65
g/l
0.28
29
35
40
45
9.58
32.88
2.3
1.4
0.34
0.37
g/l
0.16
29
34
47
65
7.88
32.77
6.4
2.4
—
—
—
0
0
75
169
5.05
32.03
1.9
1.2
—
—
—
0
0
39
47
8.92
30.39
2.4
1.4
—
—
—
0
0
298
1681
2.93
29.94
5.3
3.5
2.32
2.36
mmol/l
6.79
277
1512
56
104
5.94
29.53
4.7
3.0
61.80
58.36
%
0.97
56
104
160
671
3.04
27.42
1.9
1.4
537.14
497.00
titre
0.12
35
160
35
42
8.89
27.32
4.1
3.5
—
—
—
0
0
117
416
3.37
26.43
4.5
2.8
71.95
71.53
e9/l
0.04
83
306
191
901
2.82
26.16
6.0
2.9
496.07
512.68
mosm/kgh2o
0.53
174
789
76
204
4.22
25.90
2.7
2.1
1.61
1.51
g/l
0.37
64
181
31
35
9.38
25.31
1.4
1.2
0.19
2.98
u/ml
0.56
24
19
78
221
4.00
24.66
5.9
1.8
23.82
6.31
iu/ml
1.10
26
52
339
2172
2.76
24.63
22.9
13.5
1.24
1.21
inr
0.37
307
1795
96
315
3.54
24.48
5.7
3.4
7.42
7.42
ph
0.33
83
256
208
1058
2.66
24.18
5.6
2.6
4.75
6.36
e6/l
0.76
194
965
203
1028
2.65
23.72
15.0
5.0
—
—
—
0
0
370
2510
2.86
23.46
12.9
6.5
11.15
11.31
umol/l
0.06
362
2390
28
31
9.51
23.17
1.5
1.8
44.08
40.73
%
0.33
28
31
70
193
4.06
22.92
2.8
1.8
1.24
2.67
ug/l
0.46
63
176
391
2755
2.97
22.58
12.3
4.8
6.51
6.61
mmol/l
0.53
384
2611
108
400
3.17
22.54
4.4
3.5
77.63
81.81
ng/l
0.26
103
351
137
582
2.87
22.39
4.1
3.2
4.61
4.86
e9/l
0.19
115
509
133
564
2.85
21.74
11.4
7.2
10.74
12.10
kpa
3.67
128
544
63
168
4.15
21.54
1.5
4.1
28.75
84.88
mg/l
0.94
50
146
132
562
2.84
21.38
11.6
7.3
7.43
7.42
ph
1.46
70
307
130
551
2.84
21.22
11.7
7.3
0.52
0.98
mmol/l
0.46
115
470
121
497
2.90
20.91
11.7
7.6
94.29
95.44
%
0.71
116
482
320
2087
2.50
20.85
5.8
3.0
193.13
114.99
ug/l
1.48
304
1928
190
980
2.52
20.83
2.6
1.5
2.19
2.47
g/l
1.00
146
559
62
168
4.07
20.73
1.5
4.1
24.51
52.91
mg/l
1.02
48
145
38
68
5.97
20.71
6.1
2.3
—
—
—
0
0
113
452
2.94
20.46
8.1
4.3
7.37
7.37
ph
0.08
95
313
111
449
2.90
19.63
3.6
2.2
0.21
0.22
g/l
0.06
104
422
88
312
3.21
19.60
2.0
1.3
121.06
289.75
u/ml
0.90
83
285
250
1492
2.36
19.45
6.0
3.2
1707.45
1099.31
ng/l
1.09
234
1260
56
156
3.92
17.97
1.5
3.7
1.33
5.55
ratio
1.03
33
86
41
91
4.82
17.61
3.8
2.9
—
—
—
0
0
132
621
2.53
17.12
5.6
2.4
216.11
120.61
ug/g
2.36
112
488
247
1527
2.23
16.96
7.7
3.3
18.44
94.35
e6/l
1.07
212
1162
240
1471
2.22
16.79
4.3
2.4
—
—
—
0
0
28
22
13.41
16.35
4.5
4.0
605.64
1335.45
u/ml
0.65
28
22
68
230
3.27
16.25
6.2
3.4
—
—
—
0
0
240
1494
2.17
15.89
3.6
2.1
235.41
193.73
u/l
0.12
234
1420
291
1974
2.14
15.18
5.3
3.6
6.28
6.23
ph
0.27
156
1076
83
327
2.85
15.18
1.6
1.5
—
—
—
0
0
236
1485
2.12
14.93
4.4
2.4
58.10
65.87
u/l
0.78
220
1359
266
1764
2.09
14.49
9.1
4.0
50.30
118.37
e6/l
1.65
215
1219
216
1328
2.11
14.39
7.5
3.2
0.28
0.53
e6/l
1.48
179
962
148
785
2.26
14.34
2.0
1.8
1304.24
1225.25
nmol/l
0.24
113
578
341
2492
2.17
14.24
7.2
4.0
27.27
3.11
estimate
0.66
96
522
33
74
4.71
13.98
1.4
1.3
147.29
166.87
au/ml
—
7
27
24
40
6.25
13.98
1.9
1.3
—
—
—
0
0
106
492
2.47
13.89
1.8
1.5
—
—
—
0
0
19
8
24.62
13.88
1.6
2.1
24.95
30.00
%
—
19
8
35
83
4.46
13.85
4.0
2.7
2.59
2.54
mmol/l
0.03
29
54
342
2517
2.15
13.82
7.4
4.1
0.00
0.01
estimate
0.97
93
492
295
2062
2.06
13.60
32.8
11.7
0.00
0.00
e9/l
0.01
272
1694
270
1831
2.04
13.50
6.8
3.9
37.68
85.50
ng/l
0.72
227
1340
121
604
2.33
13.44
1.9
1.5
—
—
—
0
0
34
81
4.43
13.38
1.5
1.3
—
—
—
0
0
388
3020
2.30
13.34
9.2
4.8
119.92
2550.19
e6/l
0.94
12
43
27
53
5.33
13.30
1.2
1.2
—
—
—
0
0
335
2470
2.09
13.14
7.2
4.0
0.00
0.00
estimate
-0.00
92
510
37
96
4.08
13.04
2.7
1.8
5.28
4.42
mmol/24h
0.91
31
83
94
427
2.48
12.84
23.3
7.5
—
—
—
0
0
104
495
2.39
12.82
14.3
3.3
7.37
7.39
ph
2.15
62
275
52
173
3.24
12.71
5.8
1.8
21.53
21.07
s
0.24
43
161
178
1059
2.06
12.58
3.8
1.7
1.52
1.23
mg/l
0.53
149
840
17
7
25.06
12.54
3.8
1.4
—
—
—
0
0
53
180
3.18
12.52
1.7
1.3
4.48
2.57
u/ml
—
6
11
25
29
9.02
12.15
2.0
2.0
402.40
506.68
e6/l
0.43
20
22
113
570
2.27
12.13
1.8
1.3
—
—
—
0
0
24
46
5.43
12.13
1.9
1.8
59.56
64.80
%
0.23
16
30
296
2140
1.95
11.62
4.6
2.7
—
—
estimate
—
0
0
125
668
2.16
11.60
19.5
6.4
103.81
104.20
mmol/l
0.40
125
668
42
130
3.44
11.50
2.1
1.5
28835.44
19191.21
e6/l
0.35
36
85
98
477
2.31
11.39
14.9
3.2
1.44
1.91
mmol/l
0.64
88
411
126
680
2.14
11.38
2.0
1.8
—
—
—
0
0
25
53
4.91
11.30
1.8
1.4
26.15
27.36
ng/l
0.05
25
53
39
118
3.50
11.05
5.0
2.9
1.80
1.62
index
0.08
25
68
24
51
4.89
10.82
3.4
2.1
1.94
0.27
mmol/l
1.00
24
51
227
1529
1.89
10.79
8.3
3.2
35.32
31.15
u/l
0.54
216
1442
38
116
3.46
10.63
1.3
1.8
—
—
—
0
0
23
48
4.98
10.58
1.0
1.1
—
—
u/ml
—
0
0
30
80
3.93
10.19
1.5
1.2
261.55
290.59
u/ml
0.18
20
41
178
1124
1.91
10.19
3.9
2.3
—
—
—
0
0
60
245
2.65
10.13
1.5
1.2
—
—
—
0
0
36
110
3.45
10.05
2.9
2.1
118.12
129.10
g/l
1.74
26
83
73
330
2.42
9.97
4.5
3.5
228.85
191.02
ng/l
0.19
65
303
25
60
4.33
9.75
1.2
1.1
—
—
—
0
0
17
15
11.69
9.63
3.0
3.1
0.60
0.60
mmol/l
0.09
17
15
209
1413
1.83
9.49
2.3
1.7
19.30
20.98
nmol/l
1.00
191
1171
102
543
2.11
9.39
6.1
2.7
6.11
7.20
umol/l
0.48
91
485
32
95
3.53
9.34
1.3
1.3
13.49
10.46
u/l
0.40
27
77
175
1127
1.85
9.25
1.4
1.3
0.58
1.76
u/ml
2.24
57
288
180
1173
1.84
9.14
5.2
2.7
356.23
338.26
umol/l
1.21
159
1009
160
1005
1.87
9.13
3.7
2.9
2.45
2.46
mmol/l
0.25
149
904
86
433
2.19
9.11
1.7
1.4
—
—
—
0
0
26
68
3.98
9.07
1.3
1.2
1.33
4.00
u/ml
—
6
30
35
114
3.23
8.85
1.4
1.3
—
—
—
0
0
196
1325
1.79
8.73
7.4
3.4
0.24
0.00
estimate
0.49
85
421
20
44
4.69
8.66
1.5
1.3
—
—
—
0
0
44
168
2.78
8.45
5.1
3.3
434.55
186.64
mg/l
0.68
22
58
14
11
13.05
8.42
1.2
1.6
—
—
—
0
0
26
72
3.76
8.39
2.5
1.5
—
—
—
0
0
26
72
3.76
8.39
2.5
1.5
—
—
—
0
0
26
72
3.76
8.39
2.5
1.5
—
—
—
0
0
26
72
3.76
8.39
2.5
1.5
—
—
—
0
0
145
905
1.85
8.33
6.3
4.1
1001.13
420.98
ng/l
0.32
119
712
76
378
2.19
8.27
7.6
3.8
—
—
—
0
0
202
1395
1.75
8.25
7.8
4.1
0.00
0.01
estimate
0.74
91
487
41
155
2.79
8.02
1.8
1.3
19.93
3.11
u/ml
—
10
28
46
185
2.64
8.00
1.7
2.2
9.54
10.71
g/l
0.76
41
169
41
156
2.77
7.93
1.9
1.3
2.83
2.60
u/ml
—
7
21
38
140
2.86
7.80
1.3
1.2
298.00
95.63
titre
—
5
16
55
246
2.39
7.66
3.0
2.2
0.00
0.01
estimate
0.49
12
75
202
1420
1.71
7.58
16.3
6.6
—
—
—
0
0
19
45
4.35
7.54
1.3
1.2
—
—
—
0
0
84
452
2.03
7.42
2.3
1.5
—
—
—
0
0
121
741
1.84
7.27
6.5
3.1
1.97
2.65
e6/l
0.63
70
346
18
42
4.41
7.27
1.9
1.3
196604.00
212959.11
e6/l
0.03
13
28
113
686
1.84
6.96
1.4
1.2
—
—
—
0
0
20
53
3.89
6.87
1.7
1.3
4945.46
1792.28
e6/l
0.65
13
36
27
88
3.19
6.84
3.0
3.6
0.97
0.78
nmol/l
0.97
20
71
17
41
4.26
6.60
1.8
1.2
—
—
—
0
0
268
2098
1.60
6.19
2.7
2.1
97.87
98.57
pmol/l
0.08
165
1026
143
962
1.68
6.08
1.8
1.8
435.88
14885947.43
pmol/l
0.50
117
786
22
68
3.34
6.07
2.5
2.0
1.01
0.90
%
0.44
16
42
16
29
5.66
6.04
1.7
1.7
46.71
27.75
%
—
10
16
17
44
3.97
6.03
1.2
1.2
—
—
—
0
0
241
1848
1.59
6.01
7.4
3.9
0.00
0.02
estimate
1.60
81
424
26
90
2.99
5.98
1.9
1.4
—
—
—
0
0
469
4305
2.59
5.97
52.8
16.2
21.32
23.54
mg/l
1.00
452
3556
31
119
2.71
5.92
1.9
1.2
72.11
31.79
u/ml
—
8
15
9
6
15.24
5.92
1.0
1.0
—
—
—
0
0
9
6
15.24
5.92
1.0
1.2
—
—
—
0
0
17
45
3.88
5.86
1.4
1.1
112.12
106.47
pmol/l
0.18
17
45
10
9
11.31
5.81
2.2
1.3
—
—
—
0
0
18
51
3.62
5.65
1.6
1.5
—
—
—
0
0
19
56
3.49
5.64
1.5
1.2
—
—
—
0
0
28
105
2.77
5.60
1.5
1.3
65.45
60.82
mmol/l
0.18
20
90
17
47
3.71
5.53
1.5
1.3
3386.63
20636.96
e6/l
—
8
27
22
73
3.11
5.44
1.7
1.7
—
—
—
0
0
21
68
3.18
5.40
1.3
1.3
—
—
—
0
0
10
11
9.25
5.31
4.3
3.2
44.15
48.64
%
—
10
11
24
86
2.88
5.22
10.9
6.8
104.75
104.81
mmol/l
0.02
24
77
24
86
2.88
5.22
10.9
6.8
11.29
10.47
mmol/l
0.73
24
77
8
6
13.52
5.09
1.0
1.0
—
—
—
0
0
19
60
3.25
5.09
2.8
1.8
32.58
32.33
pg
0.09
19
60
122
832
1.62
4.79
1.4
1.3
16.86
11.93
u/ml
0.28
48
308
128
884
1.60
4.77
1.4
1.3
50.58
31.41
iu/ml
0.57
37
277
77
465
1.78
4.74
2.9
2.2
0.00
0.06
estimate
0.78
17
89
66
382
1.84
4.67
2.2
2.6
10.05
6.34
ug/l
0.58
57
333
16
49
3.34
4.50
3.9
1.7
10.53
10.71
%
0.06
16
49
91
587
1.67
4.42
1.4
1.3
—
—
—
0
0
210
1645
1.48
4.31
4.9
3.3
5.95
7.25
mmol/l
4.85
187
1367
9
13
7.03
4.18
2.8
1.3
—
—
—
0
0
43
224
2.01
4.16
1.4
1.2
—
—
—
0
0
34
163
2.17
4.08
1.6
1.4
225.71
288.50
ug/g
1.02
18
101
8
10
8.11
4.07
1.0
3.1
—
—
—
0
0
8
10
8.11
4.07
4.5
2.7
—
—
—
0
0
8
10
8.11
4.07
2.3
1.6
—
—
—
0
0
15
48
3.19
3.96
1.7
2.6
1.79
0.90
g/24h
—
9
31
11
23
4.87
3.89
1.0
1.8
—
—
—
0
0
15
49
3.13
3.83
2.5
2.1
—
—
—
0
0
23
97
2.44
3.70
1.7
1.2
—
—
—
0
0
336
2932
1.45
3.64
6.8
3.3
79.03
49.22
u/l
1.70
317
2734
16
57
2.87
3.55
1.4
1.5
278.27
273.84
mosm/kgh2o
0.30
11
45
13
344
0.36
3.51
1.2
1.4
—
—
—
0
0
8
13
6.23
3.51
4.3
2.2
13007.38
4.22
ug/l
—
8
13
15
52
2.94
3.49
1.5
1.0
—
—
—
0
0
13
42
3.15
3.39
1.2
1.2
—
—
—
0
0
78
519
1.60
3.34
3.9
4.3
318.04
29.10
ug/l
0.45
68
437
13
39
3.39
3.24
1.2
1.2
—
—
—
0
0
11
29
3.85
3.20
1.2
1.0
—
—
—
0
0
9
20
4.56
3.12
1.6
1.2
—
—
—
0
0
127
1644
0.69
3.12
3.9
3.4
—
—
—
0
0
70
462
1.60
3.10
3.7
2.5
35.09
33.41
u/l
0.16
65
382
6
8
7.57
3.06
1.2
1.0
—
—
—
0
0
388
3524
1.46
3.05
5.6
4.5
15.32
14.86
pmol/l
2.85
355
3212
204
1668
1.38
3.02
5.4
3.6
—
0.67
—
0
6
14
51
2.80
3.01
1.8
1.7
—
—
—
0
0
55
349
1.65
2.86
5.9
3.5
—
—
—
0
0
147
1149
1.40
2.82
5.6
3.9
—
0.25
—
0
12
24
117
2.10
2.82
2.2
1.9
1.62
4.42
iu/l
2.62
13
48
14
53
2.69
2.81
1.6
1.3
—
—
—
0
0
7
14
5.05
2.73
1.0
1.2
153.43
103.74
iu/ml
—
7
14
10
29
3.50
2.70
2.5
3.5
1087.60
767.76
mg
—
10
29
14
55
2.59
2.63
1.8
1.2
—
—
—
0
0
217
1821
1.34
2.62
2.6
2.2
—
—
—
0
0
5
7
7.20
2.55
1.2
1.1
—
—
—
0
0
6
11
5.50
2.55
2.0
1.8
—
—
—
0
0
9
26
3.51
2.49
8.8
2.5
1.44
0.88
index
—
9
26
9
27
3.38
2.40
1.3
4.1
14.56
16.55
%
—
9
27
5
8
6.30
2.37
1.2
1.0
6.50
6.56
mg/g
—
5
8
22
113
1.99
2.29
1.2
1.2
—
—
—
0
0
325
3548
0.76
2.23
58.6
21.3
327.20
331.57
g/l
12.89
325
3534
9
30
3.04
2.15
1.6
1.9
6.62
6.65
mmol/l
—
9
21
461
4409
1.63
2.13
37.2
14.6
—
—
—
0
0
10
39
2.60
1.95
1.3
1.2
—
—
—
0
0
8
27
2.99
1.94
1.0
1.0
1232.25
1473.56
miu/ml
—
8
27
11
45
2.48
1.94
1.3
1.1
—
—
—
0
0
24
137
1.79
1.87
14.1
10.4
—
—
—
0
0
35
223
1.61
1.85
1.0
1.1
—
48.00
—
0
5
30
467
0.62
1.79
1.9
1.6
—
—
—
0
0
9
36
2.53
1.74
9.6
2.5
22.00
14.81
index
—
9
26
8
30
2.69
1.73
1.4
1.4
85.25
74.27
umol/l
—
8
30
7
24
2.94
1.73
1.0
1.2
—
—
—
0
0
5
13
3.87
1.72
1.2
1.2
—
—
—
0
0
27
165
1.67
1.68
2.5
2.7
—
—
—
0
0
6
19
3.18
1.66
1.2
1.2
173.50
183.67
mmol/24h
—
6
19
14
70
2.03
1.60
1.2
1.2
0.52
2.08
u/ml
—
9
38
183
1582
1.25
1.58
5.0
3.3
55.73
38.54
mg/l
0.50
125
971
186
1614
1.24
1.54
6.0
4.1
14.85
6.70
mg/mmol
1.40
123
963
44
610
0.69
1.52
3.1
3.1
0.49
0.75
ug/l
3.46
32
380
7
27
2.61
1.52
2.1
2.6
—
—
—
0
0
6
21
2.88
1.51
1.0
1.0
—
—
—
0
0
6
21
2.88
1.51
1.0
1.0
—
—
—
0
0
6
21
2.88
1.51
1.0
1.0
—
—
—
0
0
14
72
1.97
1.50
1.4
1.1
—
—
—
0
0
21
124
1.72
1.49
1.8
1.9
42.00
38.82
nmol/l
0.32
21
119
20
117
1.74
1.47
1.4
1.4
173.11
278.74
miu/ml
—
8
50
9
41
2.22
1.37
1.2
3.1
—
—
—
0
0
24
151
1.62
1.37
1.5
1.2
—
—
—
0
0
19
112
1.72
1.37
3.6
4.5
—
—
—
0
0
6
23
2.63
1.37
1.7
1.5
—
—
—
0
0
126
1060
1.25
1.36
7.2
4.2
1.02
1.02
kg/l
1.72
88
707
54
406
1.37
1.32
1.3
1.2
—
—
—
0
0
426
4079
1.31
1.31
7.1
5.7
1.96
1.94
mu/l
0.09
399
3754
413
4294
0.77
1.30
5.7
5.3
1.58
1.52
mmol/l
1.91
381
3949
19
114
1.69
1.30
1.1
1.2
—
—
—
0
0
38
270
1.44
1.28
1.2
1.1
—
—
—
0
0
44
323
1.40
1.25
3.0
2.6
28.52
23.42
au/ml
—
5
25
11
56
1.99
1.23
1.2
1.1
2.36
1.05
u/ml
—
6
27
13
72
1.83
1.16
1.4
1.1
—
—
—
0
0
5
20
2.51
1.15
1.0
2.0
—
—
—
0
0
5
113
0.44
1.14
1.0
1.1
—
0.74
—
0
19
7
30
2.35
1.12
1.0
1.0
—
—
—
0
0
7
30
2.35
1.12
1.4
3.6
7.61
7.64
mmol/l
—
7
30
10
51
1.98
1.12
2.0
2.8
—
—
—
0
0
6
121
0.49
1.06
1.0
1.1
1.55
1.57
g/l
—
6
121
14
83
1.71
1.02
3.9
2.0
79.67
9765.85
u/l
—
6
36
138
1210
1.19
0.99
1.5
1.4
—
—
—
0
0
5
23
2.19
0.98
1.0
1.3
140.40
154.83
nmol/l
—
5
23
418
4314
0.80
0.97
5.8
5.4
4.70
4.69
mmol/l
0.12
391
3986
425
4378
0.80
0.96
6.2
6.2
2.61
2.72
mmol/l
1.73
394
4030
14
220
0.63
0.94
1.3
1.1
—
—
—
0
0
47
370
1.30
0.89
4.2
2.4
6.17
6.17
ph
0.01
30
240
397
4108
0.83
0.86
5.0
4.5
1.38
1.28
mmol/l
1.60
366
3744
12
190
0.62
0.84
1.3
1.8
—
—
—
0
0
6
32
1.89
0.82
1.3
1.1
—
—
—
0
0
475
4666
1.41
0.81
68.7
25.0
4.25
4.46
e12/l
15.13
470
4558
6
33
1.83
0.79
1.0
1.3
—
—
—
0
0
13
84
1.56
0.72
1.2
1.0
—
—
—
0
0
30
386
0.76
0.71
1.5
1.4
—
—
—
0
0
5
27
1.86
0.68
1.2
1.2
—
—
—
0
0
9
141
0.63
0.61
1.0
1.1
—
—
—
0
0
7
113
0.61
0.58
1.1
1.4
—
—
—
0
0
0
23
0.00
0.58
0.0
12.2
—
930.57
—
0
23
185
1978
0.90
0.55
2.1
2.0
1.51
1.34
mmol/l
1.54
159
1645
14
99
1.43
0.54
1.9
1.8
189.50
223.27
pmol/l
0.72
14
90
37
305
1.23
0.53
1.5
1.2
158.69
122.23
u/ml
0.14
11
121
10
66
1.53
0.53
1.2
1.3
—
—
nmol/l
—
0
0
28
225
1.26
0.50
5.1
3.6
1.02
1.02
ratio
0.27
28
214
20
154
1.31
0.49
1.0
1.1
—
—
—
0
0
329
3176
1.11
0.48
6.2
4.3
—
0.14
—
0
7
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
8
60
1.34
0.40
1.0
1.2
—
—
—
0
0
26
214
1.23
0.40
2.2
2.5
—
—
—
0
0
7
105
0.66
0.39
1.1
1.4
—
—
—
0
0
8
112
0.71
0.37
1.1
1.4
—
—
—
0
0
8
112
0.71
0.37
1.1
1.4
—
—
—
0
0
8
111
0.72
0.37
1.1
1.4
—
—
—
0
0
6
86
0.69
0.33
1.0
1.2
—
—
—
0
0
16
129
1.25
0.30
2.1
1.2
0.88
0.93
g/l
0.56
16
129
35
307
1.15
0.29
1.9
1.6
—
—
—
0
0
11
85
1.30
0.28
1.4
1.3
194.83
19.82
u/l
0.49
11
70
19
159
1.20
0.27
1.2
1.3
—
—
—
0
0
429
4235
1.09
0.26
5.7
5.4
5.62
5.96
mmol/l
7.02
389
3886
96
1017
0.93
0.23
5.9
5.3
1.43
2.28
ug/l
1.82
86
906
367
3612
1.06
0.21
59.9
20.3
14.43
13.67
%
17.14
367
3577
0
10
0.00
0.21
0.0
1.2
—
1.73
—
0
10
0
10
0.00
0.21
0.0
1.0
—
8.21
—
0
5
0
10
0.00
0.21
0.0
2.3
—
5557.40
—
0
10
6
49
1.23
0.20
1.2
1.4
—
—
—
0
0
10
81
1.24
0.19
1.2
1.0
—
—
—
0
0
6
53
1.13
0.18
1.0
1.1
—
—
—
0
0
420
4157
1.07
0.18
7.5
6.8
39.44
39.37
mmol/mol
0.05
392
3884
7
59
1.19
0.18
1.1
1.1
—
—
—
0
0
9
108
0.83
0.13
1.4
1.6
388.44
308.58
mu/l
—
9
101
24
223
1.08
0.09
1.7
1.9
—
—
—
0
0
6
55
1.09
0.09
1.0
1.2
—
—
—
0
0
33
315
1.05
0.06
1.2
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
4.5
—
7.58
—
0
8
0
8
0.00
-0.00
0.0
1.0
—
0.02
—
0
8
0
6
0.00
-0.00
0.0
1.5
—
0.50
—
0
6
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
52.00
—
0
8
6
67
0.89
-0.00
1.2
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
6
64
0.94
-0.00
1.2
1.9
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
19.18
—
0
6
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint DRUGADVERS_OSTEOPO and mortality.

Females

Parameter HR [95% CI] p-value
DRUGADVERS_OSTEOPO 2.759 [2.28, 3.34] < 0.001
Birth year 0.999 [0.99, 1.01] 0.848

During the follow-up period (1.1.1998 — 31.12.2019), 395 out of 1151 females with DRUGADVERS_OSTEOPO died.

Males

Parameter HR [95% CI] p-value
DRUGADVERS_OSTEOPO 3.158 [2.41, 4.14] < 0.001
Birth year 0.986 [0.98, 1.0] 0.011

During the follow-up period (1.1.1998 — 31.12.2019), 217 out of 617 males with DRUGADVERS_OSTEOPO died.

Mortality risk

Mortality risk for people of age

years, who have DRUGADVERS_OSTEOPO.

N-year risk Females Males
1 0.322% 0.638%
5 1.866% 4.02%
10 4.474% 9.482%
15 8.094% 17.051%
20 15.429% 26.671%

Relationships between endpoints

Index endpoint: DRUGADVERS_OSTEOPO – Drug-induced osteoporosis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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