No definition available.
Drug-induced headache, not elsewhere classified
DRUGADVERS_HEADA_NOT_ELSEW_CLASSIFIED
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519870 |
1. Apply sex-specific ruleNone |
519870 |
2. Check conditionsNone |
519870 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
216 |
4. Check minimum number of eventsNone |
216 |
5. Include endpointsNone |
216 |
6. Filter based on genotype QC (FinnGen only) |
206 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Drug-induced headache, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Other headache syndromes
- Episodal and paroxysmal disorders
- Neurological diseases
- Neurological diseases, wide definition
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1129 | 777 | 342 |
| Only index persons | 1067 | 749 | 318 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.03 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 46.97 | 46.58 | 48.11 |
| Only index persons | 46.83 | 46.39 | 47.85 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 206 | 165 | 41 |
| Unadjusted period prevalence (%) | 0.05 | 0.06 | 0.02 |
| Median age at first event (years) | 48.40 | 46.97 | 54.16 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 216
- Matched controls
- 2160
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G44.4
ICD-10 Finland
Drug-induced headache, not elsewhere classified
+∞
312.8
216
*
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
18.6
104.3
110
114
G43.3
ICD-10 Finland
Complicated migraine
33.3
93.0
64
27
N03AX11
ATC
topiramate; oral
22.7
82.3
67
42
3007
Kela drug reimbursment
Erenumab and fremanezumab
33.2
81.0
55
22
N02CD01
ATC
erenumab; parenteral
41.5
73.4
46
14
N02CC06
ATC
eletriptan; oral
15.7
63.2
62
54
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
9.5
62.6
118
244
G43.9
ICD-10 Finland
Migraine, unspecified
11.1
62.1
84
117
N02CD03
ATC
fremanezumab; systemic
32.5
59.5
40
15
G43
ICD-10 Finland
Migraine
11.7
56.5
69
83
N02CC04
ATC
rizatriptan; oral
11.0
54.5
70
90
N02CC07
ATC
frovatriptan; oral
12.1
53.9
63
71
R51.80
ICD-10 Finland
Headache
7.9
52.4
120
296
N06CA01
ATC
amitriptyline and psycholeptics; systemic
9.5
52.3
79
124
G44.2
ICD-10 Finland
Tension-type headache
7.8
50.6
107
242
N02CC05
ATC
almotriptan; oral
10.4
41.2
52
64
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
7.5
38.4
69
128
N03AG01
ATC
valproic acid; systemic, rectal
9.3
38.3
53
73
N02CC02
ATC
naratriptan; oral
15.4
35.6
33
25
N02CC03
ATC
zolmitriptan; nasal, oral
8.2
35.6
55
86
C09CA06
ATC
candesartan; oral
5.4
34.1
113
364
N89
ICPC
Migraine
8.1
30.8
47
72
N06AA09
ATC
amitriptyline; systemic
6.3
28.1
56
113
N01
ICPC
Headache
5.0
25.9
74
205
N06AX21
ATC
duloxetine; oral
5.0
25.3
71
193
N02CD06
ATC
rimegepant; oral
41.5
23.7
29
8
C07AA05
ATC
propranolol; systemic
4.2
23.5
96
346
N03AX16
ATC
[U] pregabalin
4.2
23.3
93
329
N03AX12
ATC
[U] gabapentin; oral
4.5
22.9
76
234
C08DA01
ATC
verapamil; systemic
8.4
22.7
32
44
R51
ICD-10 Finland
Headache
6.7
22.1
39
69
M01AG02
ATC
tolfenamic acid; oral, rectal
4.3
21.6
77
249
A02BC03
ATC
lansoprazole; oral
3.9
21.4
100
391
C07AB02
ATC
metoprolol; systemic
4.4
20.9
67
200
A03FA01
ATC
metoclopramide; systemic, rectal
3.9
20.8
94
358
M03AX01
ATC
botulinum toxin; parenteral
25.5
19.6
27
12
G43.8
ICD-10 Finland
Other migraine
16.2
19.3
31
22
G44.0
ICD-10 Finland
Cluster headache syndrome
23.5
19.2
27
13
N02AX02
ATC
tramadol; systemic, rectal
3.5
18.3
130
650
H02AB07
ATC
prednisone; oral
4.3
17.6
54
154
Z01.8
ICD-10 Finland
Other specified special examinations
3.6
17.6
79
295
H02AB06
ATC
prednisolone; systemic
3.4
17.1
140
753
N02CD07, ,
ATC
69.0
17.0
19
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.3
17.0
126
637
N06AX16
ATC
venlafaxine; oral
3.8
16.2
64
218
N02CD02
ATC
galcanezumab; parenteral
36.5
16.0
20
6
N05BA01
ATC
diazepam; systemic, rectal
4.0
16.0
56
175
A02BC05
ATC
esomeprazole; systemic
3.2
15.7
123
634
M03BX02
ATC
tizanidine; oral
3.8
14.6
175
1137
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.7
14.1
53
173
N03AX09
ATC
lamotrigine; oral
5.1
13.6
31
69
M79.1
ICD-10 Finland
Myalgia
3.3
13.4
66
256
A02BA02
ATC
ranitidine; systemic
3.3
13.1
62
234
N03AE01
ATC
clonazepam; systemic
5.5
12.8
26
52
M03BC51
ATC
orphenadrine, combinations; systemic
2.9
12.7
93
449
C07AB07
ATC
bisoprolol; oral
2.8
12.4
119
659
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.8
12.3
42
128
M01AE03
ATC
ketoprofen; systemic, rectal
2.8
12.2
102
525
N06AB03
ATC
fluoxetine; oral
3.6
12.2
47
155
AA1AD
NOMESCO Finland
CT of head and brain
2.9
12.2
81
370
A02BC02
ATC
pantoprazole; systemic
3.3
11.9
173
1184
N05CF02
ATC
zolpidem; oral
3.1
11.4
60
239
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.8
11.4
78
360
M01AE02
ATC
naproxen; oral, rectal
2.9
11.2
160
1064
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.7
11.2
39
120
N06AX11
ATC
mirtazapine; oral
2.7
11.2
104
560
N06AB04
ATC
citalopram; systemic
2.9
11.1
67
288
N06AX12
ATC
bupropion; oral
3.9
11.0
35
101
N05AH04
ATC
quetiapine; oral
2.9
10.7
65
280
D01
ICPC
Abdominal pain/cramps general
3.2
10.7
49
180
G44.8
ICD-10 Finland
Other specified headache syndromes
14.1
10.4
17
13
R53
ICD-10 Finland
Malaise and fatigue
2.6
10.2
87
444
R42
ICD-10 Finland
Dizziness and giddiness
2.8
10.2
69
314
A06AC01
ATC
ispaghula (psylla seeds); oral
2.7
10.1
78
379
D06
ICPC
Abdominal pain localized other
3.6
10.0
37
118
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.5
9.8
119
713
N02CA52
ATC
ergotamine, combinations excl. psycholeptics; oral
14.3
9.8
16
12
N05BA04
ATC
oxazepam; oral
2.6
9.8
82
414
N02CA01
ATC
dihydroergotamine; nasal, systemic
57.7
9.7
11
*
WZC00
NOMESCO Finland
Treatment plan or consultation
2.5
9.6
103
582
N02BE01
ATC
paracetamol; systemic, rectal
5.6
9.6
207
1736
L01
ICPC
Neck symptom/complaint
2.8
9.6
60
261
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
4.1
9.5
28
76
G43.2
ICD-10 Finland
Status migrainosus
31.6
9.5
12
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.2
9.4
42
151
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.1
8.9
41
150
H02AB04
ATC
methylprednisolone; systemic
2.9
8.8
47
187
N02AJ06
ATC
codeine and paracetamol; systemic
2.4
8.8
121
756
N02CX04, ,
ATC
9.6
8.7
17
19
N06AA10
ATC
nortriptyline; systemic
7.9
8.7
19
26
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.4
8.5
83
445
M03BC01
ATC
orphenadrine (citrate); systemic
2.4
8.4
77
400
Z76.0
ICD-10 Finland
Issue of repeat prescription
2.4
8.4
86
470
N02CD05
ATC
eptinezumab; parenteral
+∞
8.4
8
*
N06AB06
ATC
sertraline; oral
2.9
8.3
43
168
R11
ICD-10 Finland
Nausea and vomiting
3.2
8.2
35
122
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.5
8.2
62
295
R51.81
ICD-10 Finland
Facial pain NOS
7.8
8.2
18
25
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
2.8
8.1
47
195
N02BF02
ATC
pregabalin; oral
3.8
8.1
26
75
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.9
7.9
42
166
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
3.5
7.9
29
92
N05CD07
ATC
temazepam; oral
3.5
7.9
29
92
R03DC03
ATC
montelukast; oral
2.6
7.8
53
238
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.1
7.8
35
126
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.0
7.6
37
139
A02BC01
ATC
omeprazole; systemic
2.4
7.5
71
372
T78.4
ICD-10 Finland
Allergy, unspecified
4.1
7.4
21
55
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
2.2
7.4
86
491
M53.0
ICD-10 Finland
Cervicocranial syndrome
2.8
7.4
40
160
M01AB05
ATC
diclofenac; systemic, rectal
2.4
7.2
161
1193
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.4
7.1
59
291
Z71.8
ICD-10 Finland
Other specified counselling
2.2
7.1
99
607
A01
ICPC
Pain general/multiple sites
2.9
7.1
36
139
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
2.7
7.1
41
170
P01AB01
ATC
metronidazole; oral, rectal
2.1
7.0
108
687
J01MA02
ATC
ciprofloxacin; systemic
2.2
7.0
92
550
A06AD11
ATC
lactulose; oral
2.9
6.9
35
135
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
3.2
6.8
28
95
R4110
NOMESCO Finland
Physiotherapy
2.3
6.8
70
378
R07.4
ICD-10 Finland
Chest pain, unspecified
2.3
6.8
71
386
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.9
6.8
35
136
K59.0
ICD-10 Finland
Constipation
3.8
6.8
21
59
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
4.3
6.8
18
45
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
3.2
6.5
27
92
N06AB10
ATC
escitalopram; oral
2.2
6.5
66
354
SAA04
NOMESCO Finland
Special examination of mouth
3.8
6.5
20
56
N05AA02
ATC
levomepromazine; systemic
5.9
6.5
17
31
N05CF01
ATC
zopiclone; oral
2.1
6.4
78
450
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
2.6
6.3
40
173
N06AX03
ATC
mianserin; oral
4.2
6.3
17
43
UJF32
NOMESCO Finland
Coloscopy
2.3
6.3
60
313
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
3.3
6.3
24
78
S01GX01
ATC
cromoglicic acid; ophthalmic
2.2
6.2
64
344
A50
ICPC
General and Unspecified, Medication/prescr/renewal
4.4
6.2
16
39
A04
ICPC
Weakness/tiredness general
2.4
6.2
48
229
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.0
6.2
101
649
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
3.3
6.1
24
79
K07.60
ICD-10 Finland
Snapping jaw
3.1
6.1
26
90
L17
ICPC
Foot/toe symptom/complaint
2.1
6.1
81
481
R20.2
ICD-10 Finland
Paraesthesia of skin
3.1
6.1
27
96
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.9
6.0
30
114
R00.2
ICD-10 Finland
Palpitations
2.8
6.0
31
120
A03FA02
ATC
cisapride; oral, rectal
3.3
6.0
24
80
XF400
NOMESCO Finland
ECG with 12 standard connections
2.6
6.0
38
164
TimeCodeWAS
↥TODO / Current known limitations:
- Only showing the top 500 codes, because showing all (sometimes 20k) makes the page too slow.
- Legend / how to read the glyphs.
- Proper column names.
- Show details (e.g. Fisher or Chi-square test, N cases and N controls) when clicking on a row.
- Explanation on the underlying data / how the TimeCodeWAS is done (e.g. matched cases / controls, eligibility).
- Download CSV not working.
- No filters and sorters.
- Limited amount of endpoints with TimeCodeWAS data.
- Cross-links to Risteys lab test pages for lab test codes.
OMOP Concept
ln(OR) -5y
ln(OR) -1y
ln(OR) -1m
ln(OR) d0
ln(OR) +1m
ln(OR) +1y
ln(OR) +5y
MCC -5y
MCC -1y
MCC -1m
MCC d0
MCC +1m
MCC +1y
MCC +5y
LabWAS
↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
130
772
2.72
11.54
5.9
4.6
37.42
36.63
g/l
0.90
121
733
50
181
3.29
11.18
4.0
2.5
31.84
27.94
u/l
0.55
43
150
164
1111
2.98
11.01
12.6
10.0
3.76
4.00
e9/l
0.98
145
980
92
476
2.62
10.59
2.8
2.1
3.12
2.76
mg/l
0.54
78
415
136
859
2.57
10.14
10.7
6.2
1.21
1.21
mmol/l
0.00
121
739
192
1456
3.87
9.96
5.9
4.3
9.68
10.22
mm/h
0.24
187
1366
153
1029
2.67
9.89
5.0
3.3
69.07
84.32
ug/l
1.47
147
978
138
887
2.54
9.77
3.3
2.5
79.41
76.13
nmol/l
0.70
133
819
88
468
2.49
9.33
2.1
1.7
0.82
0.89
mg/l
0.10
67
369
98
560
2.37
8.73
3.7
2.1
131.48
305.35
u/l
0.83
93
541
124
786
2.36
8.67
2.4
2.0
93.74
98.04
pmol/l
0.51
61
414
26
75
3.80
8.11
1.7
1.5
—
—
—
0
0
121
778
2.26
7.93
7.9
5.6
1.21
1.21
mmol/l
0.19
116
717
107
668
2.19
7.39
3.5
3.5
16.80
40.53
ng/l
1.65
52
402
192
1544
3.19
7.22
6.6
4.7
14.47
14.54
pmol/l
0.15
187
1448
28
94
3.27
6.95
1.5
2.8
34.89
39.90
u/l
0.80
28
86
91
544
2.16
6.90
1.6
1.3
0.64
1.77
u/ml
1.67
22
166
39
161
2.74
6.75
2.9
2.4
14.14
19.47
au/ml
—
7
14
19
50
4.07
6.69
1.3
1.1
3.00
2.97
e6/l
0.01
11
38
20
55
3.91
6.64
1.3
1.4
—
—
—
0
0
19
51
3.99
6.52
1.3
1.2
336.85
188.80
e6/l
0.21
13
40
78
448
2.16
6.47
2.7
3.1
727.37
697.73
ng/l
0.03
64
372
31
120
2.85
6.03
2.8
1.6
—
—
—
0
0
65
356
2.18
6.02
2.7
2.5
2.41
2.44
mmol/l
1.15
59
315
54
274
2.29
6.02
4.9
2.7
6.10
3.36
e6/l
0.70
29
127
52
261
2.31
5.94
1.6
1.6
1120.58
1216.90
nmol/l
0.28
39
196
77
455
2.08
5.84
1.4
1.3
13.99
33.11
iu/ml
2.58
19
140
99
645
1.99
5.69
5.0
3.0
—
—
—
0
0
178
1437
2.36
5.57
11.5
7.8
74.01
76.42
u/l
0.48
171
1357
206
1795
4.19
5.41
8.1
5.6
1.62
1.82
mu/l
2.24
201
1687
43
207
2.35
5.37
10.3
5.4
103.93
104.07
mmol/l
0.06
43
207
8
6
13.77
5.12
1.5
1.2
—
—
—
0
0
60
339
2.07
5.03
1.6
1.7
460.48
39130871.63
pmol/l
0.50
54
299
25
95
2.85
5.02
3.8
2.8
23.85
24.26
mmol/l
0.19
25
95
82
518
1.94
5.02
1.9
1.6
22.19
21.22
nmol/l
0.29
72
452
81
521
1.89
4.63
4.4
2.8
0.07
0.37
e6/l
3.64
58
374
68
413
1.94
4.62
1.3
1.3
1.24
10.17
u/ml
3.00
28
174
54
307
2.01
4.41
4.7
2.6
1.45
0.88
e6/l
0.72
31
159
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
8
9
9.17
4.31
1.4
1.2
—
—
—
0
0
93
636
1.81
4.31
2.9
3.1
2.33
2.35
mmol/l
1.11
83
588
31
143
2.36
4.24
2.1
2.3
0.22
0.22
g/l
0.14
25
137
203
1804
3.08
4.11
21.0
12.7
87.26
86.84
ml/min/173m2
0.11
195
1658
8
10
8.25
4.09
1.3
1.0
2168.25
1972.60
miu/ml
—
8
10
136
1051
1.79
4.09
7.3
4.3
6.14
6.47
mmol/l
1.28
131
979
30
145
2.24
3.69
4.3
4.1
4.35
4.74
pmol/l
1.04
25
131
31
152
2.21
3.68
1.5
1.3
89.21
320.94
u/ml
0.78
31
138
23
99
2.48
3.65
1.6
1.9
3.61
4.73
iu/ml
—
9
27
47
271
1.94
3.64
2.4
1.9
—
—
—
0
0
207
1905
3.08
3.61
26.7
13.8
18.84
19.64
mg/l
0.14
178
1514
55
338
1.84
3.51
6.1
3.4
49.06
240.47
ng/l
1.09
32
222
15
53
2.97
3.43
1.5
1.2
288.40
323.05
ug/g
—
10
26
11
28
4.08
3.34
1.4
1.1
—
—
—
0
0
165
1390
1.79
3.29
4.4
3.5
—
—
—
0
0
14
51
2.87
3.05
1.4
1.1
1.55
2.01
u/ml
—
6
23
19
82
2.44
3.01
2.5
1.5
—
—
—
0
0
129
1032
1.62
2.98
5.5
3.7
0.00
0.00
estimate
0.50
39
216
91
669
1.62
2.98
4.1
3.1
24.49
27.21
u/l
1.81
86
642
130
1048
1.60
2.86
5.4
3.7
0.00
7.45
estimate
0.50
39
218
16
66
2.54
2.78
1.3
1.2
—
—
—
0
0
5
6
8.49
2.76
1.0
1.3
—
—
—
0
0
15
61
2.57
2.68
1.9
1.7
—
—
—
0
0
129
1052
1.56
2.59
5.6
3.8
0.00
0.01
estimate
0.50
38
207
14
56
2.60
2.59
1.2
1.2
—
—
—
0
0
8
21
3.91
2.49
1.3
1.1
—
—
—
0
0
19
90
2.22
2.47
3.8
2.6
0.62
0.60
%
0.08
19
90
193
1752
1.95
2.43
4.3
3.9
1.32
1.25
mmol/l
0.81
184
1634
8
22
3.73
2.39
1.4
1.2
—
72.20
—
0
5
19
92
2.17
2.35
3.8
2.6
1.45
1.26
%
0.22
19
92
196
1795
1.99
2.30
5.4
4.5
5.57
5.77
mmol/l
2.87
191
1685
15
66
2.37
2.30
1.3
1.2
—
—
—
0
0
6
13
4.71
2.28
2.7
4.1
310.33
721.15
u/ml
—
6
13
7
18
3.98
2.27
1.1
1.1
—
—
—
0
0
5
9
5.66
2.22
2.0
2.0
103.80
114.56
%
—
5
9
7
19
3.77
2.17
1.1
1.2
—
—
—
0
0
46
308
1.63
2.12
2.4
2.0
—
—
—
0
0
76
572
1.51
2.11
5.1
3.9
0.00
0.00
estimate
0.50
33
209
7
20
3.58
2.07
1.3
1.1
—
—
—
0
0
7
20
3.58
2.07
1.3
1.2
—
—
—
0
0
14
63
2.31
2.06
1.6
1.8
—
—
—
0
0
6
15
4.08
2.05
1.0
1.3
94.67
109.13
pmol/l
—
6
15
36
228
1.69
2.04
3.0
2.5
3.83
6.03
umol/l
1.99
29
201
209
1989
2.57
2.02
17.3
11.1
25.02
24.97
u/l
0.02
209
1948
189
1727
1.76
2.01
5.8
5.6
37.22
38.39
mmol/mol
1.41
183
1643
63
462
1.51
1.96
2.9
2.7
298.88
315.60
umol/l
0.83
57
416
30
183
1.74
1.95
1.3
1.3
41.70
145.03
u/ml
—
9
75
6
17
3.60
1.85
1.0
1.1
—
—
—
0
0
14
67
2.17
1.80
1.1
1.3
—
—
—
0
0
30
188
1.69
1.78
3.1
1.9
—
—
—
0
0
8
30
2.73
1.74
2.1
1.2
—
—
—
0
0
5
13
3.91
1.72
1.2
1.2
—
—
—
0
0
8
31
2.64
1.67
3.3
2.5
5.77
7.66
pmol/l
—
8
31
6
19
3.22
1.67
1.5
1.6
—
—
—
0
0
6
19
3.22
1.67
1.5
1.6
—
—
—
0
0
6
19
3.22
1.67
1.5
1.6
—
—
—
0
0
6
19
3.22
1.67
1.5
1.6
—
—
—
0
0
10
41
2.51
1.66
1.1
1.4
—
—
—
0
0
6
20
3.06
1.59
1.5
1.5
—
—
—
0
0
6
20
3.06
1.59
1.5
1.3
—
—
—
0
0
6
20
3.06
1.59
1.5
1.6
—
—
—
0
0
27
170
1.67
1.58
1.7
1.4
30.20
24.47
iu/l
0.37
21
149
16
86
1.93
1.55
2.0
1.3
—
—
—
0
0
21
124
1.77
1.54
1.2
1.1
—
—
—
0
0
5
15
3.39
1.53
2.2
1.7
—
—
—
0
0
65
502
1.42
1.52
1.9
1.6
—
—
—
0
0
47
341
1.48
1.52
2.4
2.1
—
—
—
0
0
6
21
2.91
1.51
1.0
1.2
—
—
—
0
0
5
16
3.17
1.44
1.2
1.1
—
—
—
0
0
5
16
3.17
1.44
1.6
1.3
—
—
—
0
0
96
799
1.36
1.43
5.3
3.6
0.00
0.03
estimate
1.08
31
181
22
135
1.70
1.42
1.5
1.4
—
—
—
0
0
7
29
2.46
1.40
2.0
1.3
—
—
—
0
0
7
29
2.46
1.40
1.4
1.9
—
—
—
0
0
9
43
2.14
1.32
1.4
1.4
—
—
—
0
0
6
24
2.54
1.31
1.8
1.3
—
—
—
0
0
6
24
2.54
1.31
2.2
1.3
—
—
—
0
0
6
24
2.54
1.31
1.8
1.3
—
—
—
0
0
5
18
2.82
1.29
2.2
1.7
—
—
—
0
0
32
223
1.51
1.26
4.5
4.2
21.10
21.88
%
0.12
15
86
199
1888
1.69
1.26
6.0
5.2
2.82
2.79
mmol/l
0.25
193
1778
6
25
2.44
1.25
1.3
1.6
—
—
—
0
0
56
436
1.38
1.24
5.0
2.2
—
—
—
0
0
196
1855
1.61
1.22
5.1
4.6
1.47
1.51
mmol/l
0.65
189
1744
6
26
2.34
1.19
1.8
1.2
—
—
—
0
0
29
202
1.50
1.15
3.1
1.8
—
—
—
0
0
17
104
1.69
1.13
14.9
5.2
22.81
24.59
mmol/l
0.90
17
104
20
128
1.62
1.13
4.3
2.2
1943.07
5899.03
u/l
—
9
46
13
74
1.81
1.09
1.8
1.8
—
—
—
0
0
9
46
2.00
1.05
1.3
1.2
—
—
—
0
0
11
60
1.88
1.05
1.7
1.4
—
—
—
0
0
5
22
2.30
1.04
1.8
1.3
—
—
—
0
0
27
190
1.48
1.03
7.0
6.5
—
—
—
0
0
176
1646
1.37
1.02
32.0
16.8
13.48
13.49
%
0.05
176
1634
12
69
1.78
0.98
2.0
1.4
—
—
—
0
0
5
23
2.20
0.98
1.0
1.2
—
—
—
0
0
0
30
0.00
0.98
0.0
3.8
—
52.36
—
0
30
19
125
1.57
0.98
1.3
1.4
—
—
—
0
0
7
37
1.92
0.95
1.6
1.2
282.43
297.53
mu/l
—
7
32
25
177
1.47
0.93
13.8
6.0
5.05
5.21
kpa
0.60
25
167
25
177
1.47
0.93
13.6
6.0
13.24
12.88
kpa
0.07
25
168
6
28
2.17
0.92
2.5
1.4
—
—
—
0
0
6
28
2.17
0.92
2.5
1.4
—
—
—
0
0
195
1865
1.47
0.89
5.4
4.7
4.78
4.74
mmol/l
0.18
190
1762
36
458
0.74
0.86
1.4
1.5
—
—
—
0
0
6
31
1.96
0.85
1.0
1.1
—
—
—
0
0
63
527
1.28
0.84
3.2
3.8
7.07
8.89
mg/mmol
0.12
42
320
72
613
1.26
0.84
4.3
2.9
0.00
0.02
estimate
0.99
30
179
5
26
1.94
0.71
1.2
1.2
0.16
0.16
nmol/l
—
5
16
11
69
1.63
0.70
6.8
4.5
1.57
1.52
%
0.06
11
62
5
27
1.87
0.69
1.6
1.3
—
—
—
0
0
211
2068
1.88
0.68
37.6
21.4
133.63
134.57
g/l
0.52
211
2047
211
2067
1.90
0.68
37.4
21.3
4.47
4.48
e12/l
0.16
211
2033
211
2067
1.90
0.68
38.9
21.5
40.08
40.40
%
0.49
211
2047
211
2066
1.92
0.68
37.3
21.2
90.61
90.70
fl
0.11
211
2047
211
2065
1.94
0.68
37.5
21.3
268.30
258.42
e9/l
1.46
211
2035
23
174
1.36
0.63
1.7
1.9
—
—
—
0
0
23
174
1.36
0.63
14.2
6.3
-0.31
1.27
mmol/l
1.32
18
142
20
148
1.39
0.62
4.8
2.8
72.29
74.93
ml/min/173m2
0.19
14
59
14
99
1.44
0.55
4.9
7.1
22.94
24.94
mmol/l
1.18
14
91
14
99
1.44
0.55
1.4
1.4
213.16
233.69
miu/ml
—
5
52
6
97
0.61
0.53
1.7
1.1
0.89
0.87
g/l
—
6
97
27
217
1.28
0.51
1.9
2.0
—
—
—
0
0
10
67
1.52
0.50
1.5
2.1
0.97
1.38
g/l
—
10
58
10
68
1.49
0.48
1.4
1.8
—
—
—
0
0
6
94
0.63
0.43
1.7
1.1
1.48
1.60
g/l
—
6
94
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
0
17
0.00
0.41
0.0
1.4
—
16.32
—
0
17
51
454
1.16
0.37
6.4
4.0
1.02
1.02
kg/l
0.05
28
293
25
209
1.22
0.36
3.9
4.6
33.28
32.22
%
0.15
18
145
6
43
1.41
0.35
1.0
1.7
—
—
—
0
0
21
173
1.24
0.34
3.4
2.8
0.55
0.69
ug/l
0.55
13
99
7
52
1.36
0.31
1.9
1.5
—
—
—
0
0
7
53
1.33
0.31
1.4
1.3
—
—
—
0
0
95
898
1.10
0.27
4.9
2.7
—
—
estimate
—
0
0
5
38
1.32
0.23
1.0
1.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
48.19
—
0
10
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
2.9
—
1.08
—
0
12
5
43
1.17
0.21
1.6
1.2
—
—
—
0
0
7
59
1.19
0.18
1.4
1.6
49.88
52.60
ug/l
—
7
59
14
163
0.85
0.18
2.1
3.2
—
—
—
0
0
28
256
1.11
0.15
2.1
2.1
3.28
3.27
ratio
0.01
22
206
11
96
1.15
0.10
1.0
1.6
—
—
—
0
0
5
48
1.04
0.09
3.6
2.7
—
—
—
0
0
12
107
1.13
0.08
1.9
1.4
—
—
—
0
0
8
75
1.07
0.07
1.5
1.9
—
—
—
0
0
85
842
1.02
0.01
2.1
1.9
1.36
1.37
mmol/l
0.05
73
733
0
8
0.00
0.00
0.0
1.4
—
188.00
—
0
8
0
8
0.00
0.00
0.0
2.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
5
49
1.02
-0.00
2.0
1.6
—
—
—
0
0
9
93
0.97
-0.00
1.4
1.7
63.48
61.77
ug/l
—
9
77
0
5
0.00
-0.00
0.0
8.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
52.93
—
0
7
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
5
51
0.98
-0.00
2.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
5.0
—
4.65
—
0
9
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
5.0
—
10.87
—
0
9
Mortality – FinRegistry
↥Association
Association between endpoint DRUGADVERS_HEADA_NOT_ELSEW_CLASSIFIED and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_HEADA_NOT_ELSEW_CLASSIFIED | 1.32 [1.0, 1.74] | 0.046 |
| Birth year | 0.995 [0.99, 1.0] | 0.258 |
During the follow-up period (1.1.1998 — 31.12.2019), 76 out of 665 females with DRUGADVERS_HEADA_NOT_ELSEW_CLASSIFIED died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_HEADA_NOT_ELSEW_CLASSIFIED | 1.614 [1.08, 2.4] | 0.019 |
| Birth year | 0.989 [0.98, 1.0] | 0.076 |
During the follow-up period (1.1.1998 — 31.12.2019), 56 out of 305 males with DRUGADVERS_HEADA_NOT_ELSEW_CLASSIFIED died.
Mortality risk
Mortality risk for people of age
years, who have DRUGADVERS_HEADA_NOT_ELSEW_CLASSIFIED.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.147% | 0.348% |
| 5 | 0.718% | 1.909% |
| 10 | 1.867% | 4.967% |
| 15 | 3.603% | 9.259% |
| 20 | 6.513% | 15.684% |
Relationships between endpoints
↥Index endpoint: DRUGADVERS_HEADA_NOT_ELSEW_CLASSIFIED – Drug-induced headache, not elsewhere classified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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