Drug-induced dystonia

DRUGADVERS_DYSTON

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G24.0#

1 out of 7 registries used, show all original rules.

135

4. Check minimum number of events

None

135

5. Include endpoints

None

135

6. Filter based on genotype QC (FinnGen only)

116

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 816 453 361
Only index persons 739 416 323
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.02 0.01
Median age at first event (years)
Whole population 48.80 52.93 43.66
Only index persons 46.80 49.61 43.17

-FinnGen-

Key figures

All Female Male
Number of individuals 116 69 47
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 47.09 48.94 44.39

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
120
Matched controls
1200
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G24.0
ICD-10 Finland
Drug-induced dystonia
+∞
173.2
120
*
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
25.7
70.5
62
48
N04AA02
ATC
biperiden; systemic
42.5
64.9
42
15
N05AH03
ATC
olanzapine; systemic
19.7
57.3
56
51
N03AE01
ATC
clonazepam; systemic
21.1
49.4
43
31
N05AX12
ATC
aripiprazole; systemic
19.7
47.7
43
33
N03AG01
ATC
valproic acid; systemic, rectal
15.4
41.2
43
42
N05AX08
ATC
risperidone; systemic
12.5
39.4
50
65
N05AH04
ATC
quetiapine; oral
10.7
39.1
75
162
F29
ICD-10 Finland
Unspecified nonorganic psychosis
16.3
37.9
37
32
N05BA01
ATC
diazepam; systemic, rectal
7.0
22.9
47
101
N05BA06
ATC
lorazepam; systemic, sublingual
10.3
21.4
27
33
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
6.9
20.5
40
81
R56.8
ICD-10 Finland
Other and unspecified convulsions
10.3
20.0
25
30
N05BA04
ATC
oxazepam; oral
5.6
19.8
63
199
G24.9
ICD-10 Finland
Dystonia, unspecified
223.5
19.1
19
*
N05AH02
ATC
clozapine; systemic
22.2
17.4
25
14
F25.9
ICD-10 Finland
Schizoaffective disorder, unspecified
41.9
17.3
21
6
N06AB04
ATC
citalopram; systemic
5.0
16.2
50
150
T36
ICD-10 Finland
Poisoning by systemic antibiotics
8.1
16.0
24
36
N05AA02
ATC
levomepromazine; systemic
14.7
15.5
26
22
N06AB03
ATC
fluoxetine; oral
5.6
15.4
36
85
N05AD01
ATC
haloperidol; systemic
17.3
15.3
24
17
P72
ICPC
Schizophrenia
18.6
15.1
23
15
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
23.7
14.3
20
10
N05CD07
ATC
temazepam; oral
6.2
14.2
28
56
N05AN01
ATC
lithium; oral
19.3
14.1
21
13
SPAT1254
SPAT
Administration of medicine
5.2
13.5
34
85
N06AX11
ATC
mirtazapine; oral
4.1
13.0
73
330
N05AB03
ATC
perphenazine; systemic, rectal
13.9
13.0
22
19
N03AX09
ATC
lamotrigine; oral
7.3
13.0
21
34
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
6.7
12.5
22
39
N05AE05
ATC
lurasidone; oral
+∞
11.6
11
*
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
19.5
11.6
17
10
C07AA05
ATC
propranolol; systemic
3.9
11.2
48
177
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
5.5
11.0
24
52
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
13.0
11.0
19
17
N06AB06
ATC
sertraline; oral
4.4
10.8
33
95
G24.3
ICD-10 Finland
Spasmodic torticollis
36.1
10.6
13
*
F20.30
ICD-10 Finland
Undifferentiated schizophrenia continuous
21.2
10.6
15
8
F20.9
ICD-10 Finland
Schizophrenia, unspecified
13.0
10.5
18
16
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
11.6
10.5
19
19
N05BE01
ATC
buspirone; oral
11.6
10.5
19
19
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
9.5
10.4
21
26
IGY02
NOMESCO Finland
Psychiatric monitoring contact
10.2
10.3
20
23
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.7
10.0
44
164
N06AX16
ATC
venlafaxine; oral
3.9
9.9
37
123
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.2
9.9
31
91
F25.10
ICD-10 Finland
Schizoaffective syndrome, depressive type with only concomitant bipolar and schizophrenic symptoms
60.0
9.8
11
*
P99
ICPC
Psychological disorders other
10.0
9.7
19
22
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
19.6
9.7
14
8
N07BB01
ATC
disulfiram; oral
9.0
9.6
20
26
N05AC02
ATC
thioridazine; oral
33.0
9.6
12
*
G24.8
ICD-10 Finland
Other dystonia
108.2
9.6
10
*
AA1AD
NOMESCO Finland
CT of head and brain
3.4
9.4
50
209
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
9.2
9.3
19
24
N05AF03
ATC
chlorprothixene; systemic
10.8
9.1
17
18
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
4.8
9.0
23
57
ZYC01
NOMESCO Finland
Remote contact by phone
5.5
8.9
19
40
F31.5
ICD-10 Finland
Bipolar affective disorder, current episode severe depression with psychotic symptoms
54.0
8.8
10
*
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
5.0
8.8
21
49
IFA01
NOMESCO Finland
Psychiatric pharmacotherapy plan, not specified
18.0
8.8
13
8
N05AL01
ATC
sulpiride; systemic
18.0
8.8
13
8
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
8.1
8.7
19
27
N05AE04
ATC
ziprasidone; systemic
22.0
8.7
12
6
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
7.5
8.6
20
31
188
Kela drug reimbursment
Psychosis requiring demanding treatment
96.6
8.5
9
*
N05CF01
ATC
zopiclone; oral
3.1
8.4
52
235
A28
ICPC
Limited function/disability NOS
3.9
8.3
29
91
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
18.8
8.3
12
7
SPAT1240
SPAT
Therapeutic discussion
4.0
8.2
27
81
G25.9
ICD-10 Finland
Extrapyramidal and movement disorder, unspecified
36.0
8.2
10
*
IGY02, ,
SPAT
24.0
8.2
11
5
A29
ICPC
General symptom/complaint other
3.7
8.1
30
98
N03AX16
ATC
[U] pregabalin
3.2
7.9
41
166
A06AD11
ATC
lactulose; oral
4.3
7.9
23
63
IGY99
NOMESCO Finland
Other psychiatric treatment contact
12.0
7.5
13
12
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
3.7
7.5
28
92
F31.6
ICD-10 Finland
Bipolar affective disorder, current episode mixed
17.1
7.4
11
7
G72.8
ICD-10 Finland
Other specified myopathies
21.6
7.3
10
5
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
13.2
7.3
12
10
SPAT1222
SPAT
Counselling/guidance promoting independent living
3.7
7.2
26
83
N05BA12
ATC
alprazolam; oral
3.8
7.0
24
74
SPAT1229
SPAT
Assessment of need for aid
8.0
7.0
15
21
ICB02
NOMESCO Finland
Psychiatric treatment plan, extended/prolonged
18.0
6.9
10
6
N05AX15
ATC
cariprazine; oral
42.5
6.8
8
*
F19.1
ICD-10 Finland
Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances, harmful use
42.5
6.8
8
*
F20.39
ICD-10 Finland
Undifferentiated schizophrenia UNS
42.5
6.8
8
*
F25.20
ICD-10 Finland
Schizoaffective syndrome, mixed type with only concomitant bipolar and schizophrenic symptoms
24.1
6.8
9
*
N06AX03
ATC
mianserin; oral
6.9
6.7
16
26
Z2446
NOMESCO Finland
Social worker
4.4
6.7
18
46
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
3.1
6.7
34
135
P29
ICPC
Psychological sympt/compl other
3.8
6.7
23
71
T90
ICPC
Diabetes non-insulin dependent
3.0
6.6
37
156
F31.4
ICD-10 Finland
Bipolar affective disorder, current episode severe depression without psychotic symptoms
73.6
6.5
7
*
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
19.3
6.4
9
5
110
Kela drug reimbursment
Parkinson's disease and comparable movement disrorders
19.3
6.4
9
5
N05AA01
ATC
chlorpromazine; systemic, rectal
19.3
6.4
9
5
AA400
NOMESCO Finland
Electroconvulsive therapy
28.3
6.3
8
*
F19.21
ICD-10 Finland
Addiction caused by several drugs in combination and by other psychoactive substances currently independent but staying in a controlling environment
28.3
6.3
8
*
F11.22
ICD-10 Finland
Addiction-induced dependence is currently independent but uses substitute intermittent medication
+∞
6.3
6
*
SPAT1216
SPAT
Assessment of functional ability
3.6
6.3
23
74
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
3.4
6.3
26
91
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
7.4
6.2
14
21
F31.0
ICD-10 Finland
Bipolar affective disorder, current episode hypomanic
13.5
6.2
10
8
IGV01
NOMESCO Finland
Psychiatric network contact
13.5
6.2
10
8
F39
ICD-10 Finland
Unspecified mood [affective] disorder
10.9
6.2
11
11
ZXY51
NOMESCO Finland
2-person team, doctor-nurse
10.9
6.2
11
11
R51.80
ICD-10 Finland
Headache
2.9
6.1
35
148
R02
ICPC
Shortness of breath/dyspnoea
3.5
6.0
23
76
N05AF05
ATC
zuclopenthixol; systemic
16.1
6.0
9
6

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
18
13
16.04
11.40
14.5
30.5
1513.72
1446.15
nmol/l
0.08
18
13
17
13
15.00
10.54
8.2
20.3
789.65
821.23
nmol/l
0.06
17
13
31
90
4.30
10.01
3.5
2.9
7.37
7.39
ph
1.15
21
55
22
50
5.16
9.54
3.9
1.3
—
—
—
0
0
67
334
3.28
9.40
2.8
2.4
48.32
69.52
u/l
0.91
62
311
21
31
7.97
9.35
4.0
1.3
—
—
—
0
0
23
58
4.67
8.81
4.6
1.3
—
—
—
0
0
83
490
3.25
8.37
8.6
7.0
1.22
1.21
mmol/l
0.52
78
428
63
321
3.03
8.22
4.2
3.1
7.03
8.17
mmol/l
0.93
55
274
23
62
4.35
8.08
4.6
1.3
—
—
—
0
0
23
62
4.35
8.08
4.6
1.3
—
—
—
0
0
52
248
2.94
7.51
6.3
4.4
—
—
—
0
0
22
61
4.19
7.43
3.6
1.3
—
—
—
0
0
56
281
2.86
7.32
3.1
3.3
80.52
66.08
mg/l
0.09
37
178
73
424
2.84
7.17
4.2
4.4
35.32
36.41
g/l
0.74
68
409
17
40
4.79
7.01
7.3
1.5
—
—
—
0
0
21
59
4.10
6.95
4.9
1.3
—
—
—
0
0
55
288
2.68
6.45
3.7
3.9
14.07
8.78
mg/mmol
0.26
33
179
35
146
2.97
6.29
1.8
1.4
1265.68
1225.85
nmol/l
0.09
28
115
47
231
2.70
6.21
2.6
1.9
2.97
2.74
mg/l
0.33
42
205
46
226
2.68
6.06
1.6
1.7
1.00
1.30
mg/l
0.34
34
175
70
433
2.48
5.56
20.0
11.0
1.25
1.15
inr
0.65
54
355
23
81
3.28
5.45
3.3
7.1
—
—
—
0
0
19
59
3.64
5.44
3.1
2.2
25.89
24.06
mmol/l
1.27
19
59
12
18
7.27
5.41
1.3
1.3
—
—
—
0
0
28
122
2.69
4.54
3.8
7.1
103.29
104.43
mmol/l
0.53
28
122
7
7
10.52
4.06
1.9
1.0
—
—
—
0
0
57
357
2.14
4.00
6.1
5.8
—
—
—
0
0
43
241
2.22
3.99
5.6
3.4
1.02
1.02
kg/l
0.14
30
158
79
563
2.18
3.94
8.2
6.1
0.03
0.04
e9/l
0.91
72
501
65
435
2.08
3.77
2.7
1.9
94.46
99.44
pmol/l
0.36
42
218
78
560
2.12
3.73
8.1
6.1
0.57
0.56
e9/l
0.20
70
500
85
631
2.19
3.72
19.7
10.5
3.98
3.99
e9/l
0.02
79
565
80
585
2.10
3.58
12.4
6.4
0.16
0.19
e9/l
1.11
72
532
78
576
2.01
3.26
8.9
6.1
1.92
1.94
e9/l
0.08
72
528
47
292
2.00
3.23
4.5
3.8
7.39
7.40
ph
0.44
39
213
57
383
1.93
3.09
4.0
3.5
28.14
70.14
e6/l
0.88
39
266
24
118
2.29
2.97
1.3
2.8
4.78
10.38
umol/l
0.98
18
111
65
464
1.87
2.87
12.5
11.4
0.00
0.00
e9/l
0.27
55
391
27
142
2.16
2.85
2.4
2.0
113.33
93.09
ug/g
0.29
18
105
13
48
2.92
2.82
3.6
2.7
0.64
0.61
%
0.08
13
48
11
34
3.46
2.81
7.7
3.4
—
—
—
0
0
12
40
3.22
2.79
1.7
1.9
—
—
—
0
0
5
6
8.62
2.77
1.0
1.0
—
—
—
0
0
50
332
1.87
2.74
3.8
2.8
54.61
41.61
e6/l
0.14
38
254
6
11
5.67
2.57
1.7
1.2
586.67
220.45
mu/l
—
6
11
11
37
3.17
2.56
4.4
4.8
37.00
37.00
°c
0.02
11
37
9
26
3.66
2.54
3.7
1.9
25.30
24.85
mmol/l
—
9
26
115
1045
3.41
2.51
25.8
13.4
27.97
21.90
mg/l
0.95
103
841
27
151
2.02
2.42
3.3
2.6
1.45
2.48
e6/l
0.38
13
70
23
121
2.11
2.41
1.5
1.4
—
—
—
0
0
22
114
2.14
2.40
2.0
1.5
—
—
—
0
0
14
59
2.55
2.39
7.5
3.9
—
—
—
0
0
21
107
2.17
2.38
8.5
7.8
7.39
7.42
ph
0.97
13
71
111
994
2.55
2.37
7.3
4.5
6.01
5.81
mmol/l
0.87
104
923
16
74
2.34
2.26
1.7
1.3
0.07
0.29
mg/l
—
6
34
53
379
1.71
2.16
6.1
3.3
19.65
44.11
ng/l
0.99
37
238
41
273
1.76
2.14
4.7
2.8
—
—
—
0
0
9
31
3.05
2.12
1.6
1.1
—
—
—
0
0
42
283
1.74
2.10
3.8
2.6
0.35
0.28
e6/l
0.12
31
203
59
439
1.68
2.05
4.3
3.2
6.28
6.21
ph
0.21
34
250
108
962
2.23
1.90
9.1
5.5
38.77
38.41
mmol/mol
0.17
102
908
0
46
0.00
1.75
0.0
1.0
—
1.58
—
0
46
0
47
0.00
1.75
0.0
1.1
—
0.85
—
0
47
6
19
3.27
1.68
2.8
2.0
90.13
92.02
%
—
6
19
17
92
1.99
1.66
4.2
4.2
1.60
0.92
%
—
5
26
5
14
3.68
1.63
1.2
1.0
—
—
—
0
0
14
71
2.10
1.61
2.9
2.3
6.71
5.95
ug/l
—
9
63
32
450
0.61
1.61
2.9
2.9
—
—
—
0
0
27
172
1.74
1.61
6.1
3.8
34.50
171.87
ng/l
0.87
18
125
22
132
1.82
1.60
1.4
1.2
—
—
—
0
0
7
27
2.69
1.54
14.1
6.1
—
—
—
0
0
5
15
3.43
1.54
1.4
1.1
—
—
—
0
0
44
323
1.57
1.52
5.0
3.3
—
—
—
0
0
38
270
1.60
1.50
3.6
2.6
—
—
estimate
—
0
0
12
59
2.15
1.49
1.2
1.2
—
—
—
0
0
69
563
1.53
1.47
5.0
3.5
91.87
0.00
estimate
0.48
15
109
12
60
2.11
1.44
1.7
1.2
—
—
—
0
0
38
273
1.57
1.43
1.5
1.3
1.31
1.83
u/ml
0.23
11
76
44
328
1.54
1.40
13.6
6.4
—
—
—
0
0
13
69
1.99
1.34
2.2
2.6
—
—
—
0
0
8
34
2.45
1.32
1.3
1.4
8.28
7.47
u/l
—
8
28
15
85
1.87
1.30
6.8
5.3
7.34
7.32
ph
—
10
63
5
19
2.70
1.23
1.2
1.1
—
—
—
0
0
67
561
1.44
1.15
5.1
3.5
0.00
0.00
estimate
-0.00
14
110
7
30
2.41
1.14
1.0
1.3
—
—
—
0
0
7
32
2.26
1.10
1.0
1.3
—
92.86
—
0
7
34
252
1.49
1.09
2.0
2.0
—
—
—
0
0
40
307
1.45
1.08
4.9
3.4
0.00
0.00
estimate
-0.00
12
107
67
567
1.41
1.05
5.1
3.6
0.23
0.00
estimate
0.47
13
104
7
34
2.12
1.04
1.4
1.0
—
—
—
0
0
33
246
1.47
1.03
1.4
1.4
2.47
2.37
g/l
0.13
17
153
34
257
1.45
0.98
5.8
5.0
—
—
—
0
0
21
144
1.56
0.95
2.0
1.9
—
—
—
0
0
21
145
1.54
0.93
2.4
2.3
2.32
2.39
g/l
0.20
16
133
51
419
1.38
0.92
5.6
3.3
0.00
0.01
estimate
0.49
12
94
27
198
1.47
0.91
1.4
1.3
1.17
6.95
u/ml
—
8
81
26
337
0.71
0.79
1.2
1.5
—
—
—
0
0
11
67
1.71
0.78
2.1
6.6
27.01
25.18
mmol/l
0.95
11
67
5
24
2.13
0.75
2.6
2.2
127.00
132.94
g/l
—
5
18
5
24
2.13
0.75
1.4
1.3
9049.80
5162.60
e6/l
—
5
15
10
60
1.73
0.74
3.3
8.7
0.66
0.66
%
—
10
60
109
1032
1.61
0.74
6.7
4.8
4.42
4.70
mmol/l
2.26
103
970
10
155
0.61
0.72
1.1
1.5
—
—
—
0
0
10
61
1.70
0.71
3.3
8.7
1.39
1.43
%
—
10
61
5
27
1.89
0.69
1.2
1.4
—
—
—
0
0
21
155
1.43
0.69
1.8
1.6
—
—
—
0
0
5
28
1.82
0.67
3.0
3.6
4.12
3.96
mmol/l
—
5
28
53
456
1.29
0.66
2.0
1.9
1.67
1.41
mmol/l
0.97
47
393
12
79
1.58
0.65
1.3
1.2
9.10
181.24
u/ml
—
6
32
0
22
0.00
0.60
0.0
1.4
—
—
—
0
0
108
1030
1.49
0.58
6.5
4.8
1.34
1.47
mmol/l
3.03
101
962
109
1043
1.49
0.56
7.3
5.3
2.58
2.76
mmol/l
1.51
101
977
9
61
1.51
0.55
1.3
2.2
—
—
—
0
0
6
38
1.61
0.55
1.3
1.4
0.23
0.24
g/l
—
6
38
6
39
1.57
0.54
1.3
1.4
1.12
1.18
g/l
—
6
39
13
94
1.43
0.48
1.6
1.2
—
—
—
0
0
103
982
1.35
0.48
5.8
4.0
1.51
1.27
mmol/l
2.17
94
912
20
157
1.33
0.47
2.8
2.2
10.85
13.99
umol/l
1.18
15
147
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
1.88
—
0
6
0
19
0.00
0.39
0.0
1.0
—
0.79
—
0
10
95
904
1.24
0.39
34.9
16.8
13.70
13.45
%
1.10
95
899
6
42
1.45
0.36
3.5
1.7
—
—
—
0
0
6
43
1.42
0.35
1.0
1.2
—
—
—
0
0
6
87
0.67
0.34
8.7
3.3
—
—
—
0
0
6
45
1.35
0.34
1.0
1.2
—
—
—
0
0
6
46
1.32
0.33
2.2
1.5
—
—
—
0
0
14
110
1.31
0.33
1.6
1.4
—
—
—
0
0
112
1092
1.38
0.30
23.7
12.3
—
—
—
0
0
24
206
1.21
0.29
2.0
1.7
—
—
—
0
0
10
76
1.34
0.29
1.4
1.2
—
16.61
—
0
7
0
11
0.00
0.21
0.0
1.1
—
186.89
—
0
11
0
11
0.00
0.21
0.0
1.5
—
9.70
—
0
11
0
10
0.00
0.21
0.0
2.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
186.97
—
0
12
0
12
0.00
0.21
0.0
1.8
—
41.16
—
0
12
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
6
50
1.21
0.20
1.2
1.3
—
329.34
—
0
24
25
224
1.15
0.19
1.4
1.3
22.92
31.26
iu/ml
—
5
68
5
69
0.71
0.17
1.2
1.8
—
—
—
0
0
10
83
1.22
0.16
2.5
2.3
—
7.80
—
0
5
13
150
0.85
0.15
1.7
1.8
—
—
—
0
0
39
407
0.94
0.08
2.1
1.9
—
—
—
0
0
12
132
0.90
0.07
1.3
1.1
—
—
—
0
0
18
171
1.06
0.03
1.6
1.4
—
667.00
—
0
40
32
318
1.01
0.00
4.8
3.0
0.00
0.01
estimate
0.49
11
87
12
117
1.03
0.00
1.6
1.4
—
—
—
0
0
49
489
1.00
0.00
3.4
2.8
—
—
estimate
—
0
0
33
334
0.98
0.00
3.8
2.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.7
—
0.57
—
0
9
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.48
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.3
—
70.13
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
11
110
1.00
-0.00
1.6
1.9
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
34.46
—
0
7
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
62.60
—
0
5
9
98
0.91
-0.00
1.2
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
34.76
—
0
7
8
86
0.93
-0.00
1.5
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint DRUGADVERS_DYSTON and mortality.

Females

Parameter HR [95% CI] p-value
DRUGADVERS_DYSTON 2.337 [1.66, 3.29] < 0.001
Birth year 0.996 [0.99, 1.0] 0.327

During the follow-up period (1.1.1998 — 31.12.2019), 94 out of 404 females with DRUGADVERS_DYSTON died.

Males

Parameter HR [95% CI] p-value
DRUGADVERS_DYSTON 3.612 [2.33, 5.59] < 0.001
Birth year 0.987 [0.98, 1.0] 0.009

During the follow-up period (1.1.1998 — 31.12.2019), 88 out of 311 males with DRUGADVERS_DYSTON died.

Mortality risk

Mortality risk for people of age

years, who have DRUGADVERS_DYSTON.

N-year risk Females Males
1 0.25% 0.727%
5 1.384% 4.207%
10 3.357% 10.293%
15 6.468% 18.763%
20 11.315% 30.864%

Relationships between endpoints

Index endpoint: DRUGADVERS_DYSTON – Drug-induced dystonia

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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