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Other nutritional anaemias

DOID EFO Endpoint Browser PheWeb

D3_NUTRIANAEMIAOTHER

anemia (phenotype): ['A reduction in the number of circulating erythrocytes or in the quantity of hemoglobin.']

Suggest a new description

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D53
  • Hospital discharge: ICD-9 — 281[8-9]
  • Hospital discharge: ICD-8 — 281[3-9]
  • Cause of death: ICD-10 — D53
  • Cause of death: ICD-9 — 281[8-9]
  • Cause of death: ICD-8 — 281[3-9]

2 out of 7 registries used, show all original rules.

472

4. Check minimum number of events

None

472

5. Include endpoints

None

472

6. Filter based on genotype QC (FinnGen only)

388

Control definitions (FinnGen only)

Control exclude
D3_NUTRIANAEMIA

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D50-D53
Name in latin
Aliae anaemiae nutritionales

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6137 3333 2692
Only index persons 3304 1855 1449
Unadjusted period prevalence (%)
Whole population 0.09 0.10 0.08
Only index persons 0.06 0.07 0.06
Median age at first event (years)
Whole population 68.88 69.46 68.16
Only index persons 62.81 61.05 65.05

-FinnGen-

Key figures

All Female Male
Number of individuals 388 186 202
Unadjusted period prevalence (%) 0.08 0.07 0.09
Median age at first event (years) 64.46 59.50 69.02

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
402
Matched controls
4015
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D53.1
ICD-10 Finland
Other megaloblastic anaemias, not elsewhere classified
7451.9
296.0
248
*
D64.9
ICD-10 Finland
Anaemia, unspecified
9.5
103.1
162
267
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
23.6
91.5
69
35
B03BA03
ATC
hydroxocobalamin; parenteral
12.5
89.8
100
104
D53.9
ICD-10 Finland
Nutritional anaemia, unspecified
+∞
70.9
66
*
107
Kela drug reimbursment
Pernicious anaemia
+∞
62.1
58
*
B81
ICPC
Anaemia vit B12/folate deficiency
13.1
56.3
57
50
K29.4
ICD-10 Finland
Chronic atrophic gastritis
15.4
47.4
43
31
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.8
37.9
181
708
28199
ICD-8 Finland
Other vitamin B12 deficiency anaemia, Other and unspecified deficiency anaemia
+∞
36.0
34
*
XW000
NOMESCO Finland
Bone marrow biopsy
7.7
34.3
51
74
D51.0
ICD-10 Finland
Vitamin B12deficiency anaemia due to intrinsic factor deficiency
325.2
30.2
30
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
10.3
23.4
27
28
2819X
ICD-9 Finland
Other deficiency anaemias, Unspecified deficiency anaemia
+∞
18.9
18
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.9
17.6
57
164
D51.9
ICD-10 Finland
Vitamin B12deficiency anaemia, unspecified
41.9
16.5
20
5
WW500
NOMESCO Finland
Blood transfusion
4.9
16.4
38
84
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
17.8
14.4
22
13
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
4.1
13.9
40
105
D53.8
ICD-10 Finland
Other specified nutritional anaemias
+∞
13.6
13
*
C03CA01
ATC
furosemide; systemic
2.2
13.6
201
1251
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.7
12.1
74
310
D46.9
ICD-10 Finland
Myelodysplastic syndrome, unspecified
23.7
11.6
16
7
M04AA01
ATC
allopurinol; systemic
2.5
11.2
85
394
N18.8
ICD-10 Finland
Other chronic renal failure
6.0
11.1
20
35
B82
ICPC
Anaemia other/unspecified
5.1
10.8
23
47
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
3.6
10.4
36
108
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.5
9.8
67
295
WVA30, ,
SPAT
3.5
9.8
34
102
B80
ICPC
Iron deficiency anaemia
7.6
9.3
21
29
UJF32
NOMESCO Finland
Coloscopy
2.1
9.2
114
643
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.5
9.2
32
96
E87.6
ICD-10 Finland
Hypokalaemia
3.8
9.1
28
77
B03XA02
ATC
darbepoetin alfa; parenteral
7.1
8.9
21
31
SPAT1254
SPAT
Administration of medicine
2.3
8.8
79
392
D64.8
ICD-10 Finland
Other specified anaemias
7.9
8.7
19
25
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.3
8.7
71
339
R53
ICD-10 Finland
Malaise and fatigue
2.0
8.5
121
716
UJF30
NOMESCO Finland
Ileoscopy through colon
2.7
8.4
46
181
28198
ICD-8 Finland
Other vitamin B12 deficiency anaemia, Alia definita
+∞
8.4
8
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.9
8.2
151
973
SPAT1255
SPAT
Intravenous administration of medicine
3.1
8.1
34
115
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.2
8.0
80
414
L04AA01
ATC
[U] ciclosporin
13.4
7.9
13
10
Z01.8
ICD-10 Finland
Other specified special examinations
2.1
7.8
92
507
D52.9
ICD-10 Finland
Folate deficiency anaemia, unspecified
45.8
7.7
9
*
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
4.5
7.0
17
39
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
4.2
6.9
18
44
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
6.8
154
1043
L04AX01
ATC
azathioprine; systemic
3.8
6.7
20
54
B03BA02
ATC
cyanocobalamin tannin complex; parenteral
22.9
6.7
9
*
L04AD02
ATC
tacrolimus; systemic
22.9
6.7
9
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.8
6.7
140
927
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
5.9
6.5
17
30
A46
ICD-10 Finland
Erysipelas
2.0
6.3
73
397
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
6.3
93
550
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.8
6.3
31
115
R56.8
ICD-10 Finland
Other and unspecified convulsions
2.9
6.3
29
104
D50.8
ICD-10 Finland
Other iron deficiency anaemias
18.3
6.3
9
5
D59.9
ICD-10 Finland
Acquired haemolytic anaemia, unspecified
+∞
6.3
6
*
28110
ICD-8 Finland
Other vitamin B12 deficiency anaemia, Other vitamin B12 deficiency
+∞
6.3
6
*
R50.9
ICD-10 Finland
Fever, unspecified
2.0
6.2
68
364
L01BA01
ATC
methotrexate; systemic
3.9
6.1
18
48
127
Kela drug reimbursment
Transplant complication
12.8
6.1
10
8
N19
ICD-10 Finland
Unspecified kidney failure
3.0
6.1
27
95

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
91
146
7.75
56.91
3.4
2.0
1.37
1.51
g/l
0.74
73
132
144
387
5.23
52.18
6.1
2.5
2.17
1.73
%
1.66
128
355
121
295
5.43
48.84
6.1
2.5
67.84
66.09
e9/l
0.13
96
225
191
822
3.52
33.68
3.3
2.0
3.04
2.89
mg/l
0.30
161
693
137
485
3.76
32.53
4.1
2.4
2.17
2.23
g/l
0.44
128
452
141
520
3.63
31.31
4.2
2.4
13.03
12.77
umol/l
0.12
130
486
127
454
3.62
29.35
4.3
2.4
25.64
22.72
%
0.81
119
425
144
594
3.21
26.01
2.2
1.7
1339.71
1190.64
nmol/l
0.99
107
443
108
411
3.22
21.91
8.9
5.4
1.06
1.04
mmol/l
0.23
103
376
49
109
4.97
21.14
2.0
3.3
1.64
3.59
ratio
1.28
28
60
51
121
4.68
20.36
2.0
3.5
48.06
108.52
mg/l
0.62
40
101
51
121
4.68
20.36
2.0
3.5
38.99
30.74
mg/l
0.80
40
101
34
57
6.42
19.80
1.4
1.5
—
—
—
0
0
220
1277
2.59
19.45
5.3
2.7
221.48
130.96
ug/l
2.93
201
1170
71
234
3.47
17.94
2.0
2.3
—
—
—
0
0
78
287
3.13
16.40
2.0
2.8
65.65
65.99
g/l
0.14
73
260
23
32
7.55
15.81
1.0
1.2
—
—
—
0
0
27
45
6.35
15.77
4.4
1.7
0.85
0.89
%
0.17
21
32
173
971
2.37
15.50
2.7
1.8
20.49
21.05
nmol/l
0.17
159
807
222
1419
2.26
14.25
3.2
2.2
89.78
94.27
pmol/l
0.80
138
717
170
978
2.28
14.05
6.2
4.4
—
—
—
0
0
24
29
8.72
11.45
1.3
1.1
—
—
—
0
0
208
1396
2.01
10.66
10.7
6.0
9.15
8.89
%
0.50
193
1314
210
1420
2.00
10.47
8.5
4.7
33.85
35.11
g/l
2.13
200
1322
69
301
2.56
10.32
2.2
2.3
0.20
0.21
g/l
1.01
62
280
206
1389
1.99
10.30
10.6
5.9
2.92
2.78
%
0.35
192
1305
206
1392
1.98
10.21
10.6
6.0
0.64
0.66
%
0.23
192
1306
219
1513
1.98
10.16
10.1
5.9
0.03
0.04
e9/l
3.12
192
1298
221
1535
1.97
10.06
10.1
6.0
1.75
1.94
e9/l
0.93
195
1363
218
1509
1.97
10.00
10.1
5.9
0.60
0.60
e9/l
0.05
192
1294
103
544
2.20
9.96
3.7
3.0
0.79
0.82
mmol/l
1.34
97
512
223
1563
1.95
9.78
10.4
6.1
0.20
0.19
e9/l
0.36
198
1366
207
1419
1.94
9.66
10.7
6.0
26.13
26.53
%
0.18
196
1352
59
251
2.58
9.25
6.4
3.6
109.34
82.07
ng/l
0.99
50
221
82
408
2.27
9.10
6.9
7.8
0.96
1.20
mmol/l
0.16
65
337
64
288
2.45
8.91
11.2
8.3
—
—
—
0
0
20
43
4.84
8.90
1.9
1.4
—
—
—
0
0
229
1651
1.90
8.90
9.4
6.1
12.05
12.15
umol/l
0.04
213
1566
54
226
2.60
8.74
3.2
3.4
7.41
7.42
ph
0.44
46
186
75
366
2.29
8.70
1.4
1.2
—
—
—
0
0
41
151
2.91
8.46
3.4
3.6
—
—
—
0
0
34
113
3.19
8.36
1.4
1.3
0.31
0.31
mg/l
0.01
20
43
80
409
2.19
8.27
6.8
7.8
7.40
7.42
ph
0.59
38
256
199
1399
1.83
8.12
10.5
6.0
58.28
58.46
%
0.07
188
1336
26
74
3.68
8.09
1.0
1.4
—
—
—
0
0
116
688
1.96
8.02
2.1
1.8
516.89
28086295.86
pmol/l
0.69
93
559
205
1460
1.82
7.97
11.1
6.4
1.20
1.21
mmol/l
0.99
190
1326
222
1624
1.82
7.85
12.9
7.1
1.20
1.21
mmol/l
0.93
195
1398
149
966
1.86
7.83
4.4
2.6
—
—
—
0
0
124
759
1.91
7.78
4.0
2.9
387.33
350.49
umol/l
2.50
110
648
45
184
2.62
7.62
9.6
10.5
14.64
15.85
%
1.95
45
178
95
538
2.00
7.44
1.8
1.6
3.00
2.43
g/l
1.24
53
315
72
368
2.16
7.41
7.8
3.8
7.38
7.38
ph
0.72
49
227
84
466
2.01
6.93
2.7
2.1
—
—
—
0
0
50
225
2.39
6.93
2.2
2.6
11.00
10.48
g/l
0.29
44
205
225
1694
1.74
6.84
14.3
9.3
4.08
4.22
e9/l
0.47
200
1476
147
982
1.78
6.81
3.1
2.6
474.46
67.44
u/l
0.50
133
909
17
41
4.28
6.60
7.2
1.4
34.59
33.20
pg
0.54
17
41
26
86
3.16
6.45
1.4
1.4
224.28
286.12
ug/g
0.75
19
53
67
351
2.09
6.44
8.0
3.7
1.83
1.91
mmol/l
0.06
58
285
17
42
4.18
6.40
1.5
1.3
183.75
287.63
u/ml
0.49
12
16
61
309
2.15
6.39
8.3
6.8
1.36
1.38
mmol/l
0.02
61
300
62
317
2.13
6.34
4.7
3.0
4.28
4.37
kpa
0.16
62
305
148
1009
1.74
6.29
7.6
4.0
7.39
7.40
ph
0.31
112
722
67
358
2.04
6.10
2.1
1.8
—
—
—
0
0
33
133
2.61
5.76
1.1
1.1
—
—
—
0
0
98
609
1.80
5.65
1.5
1.3
3.90
1.67
u/ml
0.38
23
165
120
795
1.72
5.53
3.6
2.7
8.03
5.33
e6/l
0.63
111
723
44
208
2.25
5.45
1.3
1.2
—
—
—
0
0
16
43
3.83
5.41
3.3
2.4
4.37
4.74
e9/l
0.20
16
43
43
205
2.23
5.23
8.4
8.5
24.15
24.50
mmol/l
0.29
43
199
65
363
1.94
5.20
2.1
1.7
—
—
—
0
0
26
98
2.76
5.17
2.5
2.7
2.14
1.58
mg/l
1.71
21
82
20
65
3.18
5.13
1.6
1.4
—
—
—
0
0
206
1591
1.60
5.10
18.7
16.6
1.27
1.31
inr
0.51
176
1344
151
1100
1.59
4.68
4.7
3.5
52.90
127.86
e6/l
0.64
131
857
180
1371
1.56
4.58
5.0
2.9
—
—
estimate
—
0
0
25
102
2.54
4.29
1.2
1.4
—
—
—
0
0
161
1209
1.55
4.29
5.4
4.3
97.63
112.29
e6/l
0.17
134
885
61
358
1.83
4.19
3.2
2.7
8.71
7.92
umol/l
0.09
55
321
143
1057
1.55
4.04
3.9
3.8
—
—
—
0
0
174
1343
1.52
4.02
3.4
2.4
80.56
78.21
nmol/l
0.40
150
1180
62
373
1.78
3.92
1.5
1.4
408.57
528.54
titre
0.27
14
89
167
1289
1.50
3.81
4.6
4.0
6.24
6.26
ph
0.07
92
732
6
5
12.14
3.77
2.5
1.2
—
—
—
0
0
6
5
12.14
3.77
5.2
9.6
5.93
5.52
mmol/l
—
6
5
49
278
1.87
3.74
7.0
4.9
1.00
0.85
%
0.24
27
97
59
356
1.77
3.70
2.1
1.5
—
—
—
0
0
136
1020
1.50
3.51
2.4
2.1
206.61
203.41
u/l
0.02
129
968
93
643
1.58
3.47
8.4
5.6
—
—
—
0
0
17
64
2.73
3.43
4.0
2.3
55.65
60.15
%
0.56
17
64
13
37
3.59
3.43
1.2
1.2
—
—
—
0
0
41
228
1.89
3.34
4.1
6.1
—
—
—
0
0
56
343
1.73
3.33
2.4
2.1
209.45
141.53
ug/g
0.91
44
268
147
1130
1.47
3.32
4.4
3.1
2.33
2.36
mmol/l
1.98
136
1016
11
28
4.00
3.30
1.8
1.1
—
—
—
0
0
45
263
1.80
3.14
6.2
4.9
0.59
0.52
%
0.10
23
86
96
684
1.53
3.11
2.8
3.2
497.43
538.59
mosm/kgh2o
1.06
82
595
124
932
1.48
3.11
4.5
3.4
0.24
0.46
e6/l
2.02
102
701
165
1310
1.44
3.10
18.6
11.9
0.00
0.00
e9/l
0.47
130
1062
16
62
2.64
3.07
1.2
1.5
—
—
—
0
0
12
36
3.40
3.04
1.4
2.6
0.28
0.89
g/24h
—
6
22
16
63
2.60
2.98
1.2
1.5
—
—
—
0
0
56
354
1.67
2.98
4.6
3.3
3.87
5.03
e9/l
0.92
45
310
92
656
1.52
2.96
5.4
4.1
105.97
199.36
ng/l
0.52
76
553
16
64
2.56
2.90
1.2
1.5
—
—
—
0
0
121
916
1.46
2.90
8.1
6.1
—
—
—
0
0
52
325
1.69
2.89
2.1
1.5
—
—
—
0
0
12
38
3.22
2.87
1.5
1.8
87.63
90.03
%
0.55
12
38
16
65
2.52
2.82
1.2
1.5
—
—
—
0
0
47
290
1.70
2.74
3.2
2.6
77.27
35.59
u/l
0.65
41
229
10
29
3.50
2.70
1.2
2.8
—
—
—
0
0
6
10
6.06
2.70
1.0
1.0
41.65
41.87
g/l
—
6
10
163
1316
1.40
2.70
5.1
4.2
69.56
42.65
ng/l
0.43
123
1006
39
229
1.78
2.70
6.5
3.1
103.54
127.38
g/l
8.64
39
222
44
268
1.72
2.69
2.0
1.5
—
—
—
0
0
8
19
4.27
2.69
1.3
1.2
—
—
—
0
0
44
269
1.71
2.66
8.3
5.6
0.05
0.09
%
0.27
22
78
196
1638
1.38
2.62
5.6
4.5
0.00
0.88
estimate
0.51
36
347
10
30
3.39
2.61
2.5
2.0
10.37
10.18
%
—
10
30
7
15
4.72
2.60
2.0
1.5
125.57
131.27
nmol/l
—
7
15
9
25
3.65
2.58
3.4
1.4
784.22
968.70
e6/l
—
9
20
259
2270
1.39
2.56
13.8
8.0
82.55
79.28
u/l
0.60
247
2135
194
1626
1.37
2.51
5.6
4.5
0.00
9.42
estimate
0.80
38
372
29
159
1.89
2.50
2.8
1.8
1.11
1.25
ug/l
0.09
24
139
94
696
1.46
2.50
2.2
1.8
1.93
1.51
mg/l
0.44
81
548
42
259
1.69
2.47
7.7
5.1
0.05
0.13
%
0.59
20
78
5
8
6.30
2.37
4.2
1.8
34.40
29.13
%
—
5
8
7
17
4.17
2.36
3.9
1.2
120.57
69.75
ng/l
—
7
17
15
65
2.36
2.33
1.2
1.5
—
—
—
0
0
97
733
1.42
2.30
5.1
4.3
—
0.31
—
0
16
41
257
1.66
2.28
3.7
3.8
1.22
1.22
mmol/l
0.07
36
220
70
499
1.49
2.25
1.3
1.3
59.86
35.07
iu/ml
0.45
25
167
234
2048
1.34
2.16
7.1
5.3
5255.57
3232.85
e6/l
—
7
41
42
269
1.62
2.16
6.0
4.0
7.30
7.35
ph
0.47
26
176
9
30
3.04
2.15
6.0
3.6
—
—
—
0
0
13
55
2.41
2.14
2.8
2.5
8.48
9.41
pmol/l
0.19
13
55
12
49
2.49
2.12
1.2
1.4
—
—
—
0
0
64
456
1.48
2.06
1.3
1.3
1.25
13.91
u/ml
2.84
14
168
189
1612
1.32
2.05
5.5
4.4
0.00
0.00
estimate
-0.00
36
352
27
155
1.79
2.05
1.5
1.3
—
—
—
0
0
42
277
1.57
1.93
3.1
2.2
0.00
0.00
estimate
—
6
57
13
58
2.28
1.92
2.2
2.6
—
—
—
0
0
206
1792
1.30
1.89
5.4
3.3
74.63
49.73
u/l
2.71
191
1669
11
46
2.43
1.86
1.8
1.5
—
—
—
0
0
11
46
2.43
1.86
1.8
1.5
—
—
—
0
0
11
46
2.43
1.86
1.8
1.5
—
—
—
0
0
11
46
2.43
1.86
1.8
1.5
—
—
—
0
0
21
115
1.87
1.86
2.3
2.8
270.45
274.76
mg/l
0.01
11
42
18
95
1.93
1.77
7.3
10.1
1.13
1.22
mmol/l
0.38
18
87
9
194
0.45
1.77
2.3
1.4
—
—
—
0
0
12
54
2.26
1.75
1.8
1.2
—
—
—
0
0
7
24
2.95
1.72
4.1
1.9
33.19
36.76
%
—
7
24
125
1027
1.31
1.72
4.7
4.0
15.68
9.10
mg/mmol
1.00
89
639
126
1037
1.31
1.71
4.0
3.2
6.74
7.42
mmol/l
1.11
117
873
18
97
1.89
1.68
1.6
1.2
—
—
—
0
0
7
25
2.83
1.65
4.3
2.8
—
—
—
0
0
28
174
1.65
1.65
1.6
1.4
—
—
—
0
0
16
84
1.94
1.61
1.5
1.2
—
—
—
0
0
7
26
2.72
1.58
1.6
1.6
—
—
—
0
0
23
137
1.72
1.58
1.8
2.0
448.09
325.09
ug/l
0.21
23
128
121
1000
1.30
1.58
4.0
3.3
72.19
54.11
mg/l
0.41
90
655
11
50
2.23
1.58
4.3
2.7
—
—
—
0
0
75
950
0.74
1.56
3.3
3.5
—
—
—
0
0
135
1137
1.28
1.52
4.3
3.3
2745.73
1779.96
ng/l
1.35
125
972
7
27
2.62
1.52
2.7
1.3
—
—
—
0
0
68
520
1.37
1.50
4.3
3.3
3.25
2.30
e6/l
0.40
37
273
14
72
1.98
1.50
7.4
11.5
11.00
11.25
mmol/l
0.11
14
67
14
72
1.98
1.50
7.4
11.5
104.71
104.79
mmol/l
0.01
14
67
9
38
2.40
1.46
1.0
1.0
—
—
—
0
0
45
326
1.43
1.37
1.5
1.3
—
—
—
0
0
6
23
2.63
1.37
1.0
1.2
—
—
—
0
0
47
345
1.41
1.33
3.3
4.2
14.49
24.89
ug/l
0.27
42
292
91
742
1.29
1.31
5.8
4.7
1.02
1.02
kg/l
1.69
67
517
8
34
2.38
1.29
1.6
1.1
—
—
—
0
0
10
48
2.11
1.28
1.5
1.9
—
—
—
0
0
5
19
2.65
1.21
4.4
1.3
573.40
478.00
e6/l
—
5
13
9
169
0.52
1.21
1.0
1.4
—
—
—
0
0
26
173
1.54
1.20
5.3
3.2
25.73
24.93
mmol/l
0.43
26
168
6
26
2.32
1.19
1.2
3.1
623.50
938.92
mg
—
6
26
6
26
2.32
1.19
1.2
1.1
—
—
—
0
0
6
26
2.32
1.19
1.2
1.5
17.17
32.00
ng/l
—
6
26
19
118
1.64
1.16
1.5
2.1
1.22
8.70
iu/ml
—
5
36
24
159
1.54
1.14
3.5
2.5
—
—
—
0
0
23
151
1.55
1.14
2.0
1.6
—
—
—
0
0
128
1106
1.23
1.12
2.1
2.3
—
—
—
0
0
7
32
2.21
1.08
1.3
1.2
—
—
—
0
0
9
45
2.02
1.05
1.0
1.1
—
—
—
0
0
9
48
1.89
1.01
1.3
2.0
12.74
10.98
mmol/l
—
9
48
7
35
2.01
1.00
1.1
1.7
—
—
—
0
0
233
2155
1.19
0.95
5.2
4.3
14.94
14.97
pmol/l
0.05
214
1929
22
150
1.49
0.94
2.5
1.9
—
—
—
0
0
98
1127
0.83
0.89
2.3
2.0
1.42
1.32
mmol/l
0.45
86
926
259
2740
0.84
0.88
6.1
6.1
2.43
2.58
mmol/l
1.76
239
2504
20
136
1.49
0.88
2.8
2.3
0.00
0.00
estimate
—
5
44
6
31
1.95
0.84
1.3
1.4
—
—
—
0
0
12
73
1.66
0.82
5.1
3.1
—
—
—
0
0
6
32
1.89
0.82
1.7
1.1
—
—
—
0
0
53
644
0.79
0.81
3.3
3.4
0.74
0.80
ug/l
0.23
36
421
32
242
1.35
0.81
5.3
3.9
—
—
—
0
0
107
939
1.19
0.78
5.5
4.4
0.00
0.01
estimate
0.50
33
327
0
26
0.00
0.78
0.0
1.0
—
0.58
—
0
10
32
244
1.34
0.78
1.3
1.5
—
—
—
0
0
0
27
0.00
0.77
0.0
1.3
—
0.08
—
0
16
83
713
1.20
0.77
3.2
3.0
2.44
2.46
mmol/l
1.31
73
640
6
34
1.77
0.76
1.5
1.2
—
—
—
0
0
9
53
1.71
0.76
2.7
1.4
—
—
—
0
0
5
25
2.01
0.73
1.2
1.5
6.36
6.86
mmol/l
—
5
25
7
39
1.81
0.72
1.4
1.1
—
—
—
0
0
7
39
1.81
0.72
1.4
1.1
—
—
—
0
0
21
151
1.41
0.72
1.1
1.2
—
—
—
0
0
254
2671
0.86
0.71
5.3
5.3
4.36
4.49
mmol/l
1.06
233
2449
253
2658
0.87
0.68
5.3
5.2
1.44
1.46
mmol/l
0.26
233
2418
5
91
0.54
0.68
3.6
1.8
62.00
41.98
nmol/l
—
5
86
137
1246
1.15
0.64
5.5
4.5
0.06
0.04
estimate
0.13
31
308
38
307
1.26
0.63
2.4
2.6
6.00
5.11
ug/l
0.18
29
266
256
2679
0.87
0.62
6.0
5.4
5.96
6.03
mmol/l
0.41
237
2422
21
157
1.35
0.60
1.2
1.3
—
—
—
0
0
8
54
1.49
0.57
2.0
1.4
0.85
0.90
nmol/l
—
8
45
291
3009
0.88
0.54
52.9
27.0
3.84
4.41
e12/l
34.89
284
2937
291
3007
0.88
0.53
53.0
27.1
240.87
243.00
e9/l
0.18
285
2946
10
66
1.53
0.52
2.7
1.3
777.90
16.11
e6/l
—
10
53
292
3009
0.89
0.47
52.8
27.1
7.04
6.87
e9/l
0.24
286
2938
12
85
1.42
0.47
1.3
2.1
120.71
128.61
g/l
—
7
69
12
85
1.42
0.47
19.3
9.7
—
—
—
0
0
10
68
1.48
0.47
2.9
1.4
395.50
177.20
e6/l
—
10
56
244
2535
0.90
0.44
4.4
4.4
1.32
1.27
mmol/l
0.49
217
2289
8
56
1.44
0.42
1.5
1.5
—
—
—
0
0
8
58
1.39
0.41
1.4
1.8
8.54
27.35
iu/l
—
8
49
119
1102
1.11
0.41
4.2
3.8
—
1.00
—
0
5
0
16
0.00
0.41
0.0
1.1
—
0.49
—
0
10
0
17
0.00
0.40
0.0
1.2
—
179.75
—
0
17
99
1072
0.90
0.40
6.0
5.9
2.24
3.50
ug/l
1.02
90
945
289
2801
1.11
0.39
34.7
18.3
30.73
25.74
mg/l
1.61
266
2359
0
19
0.00
0.39
0.0
3.0
—
21.40
—
0
5
10
134
0.74
0.35
1.9
2.8
—
—
—
0
0
6
43
1.40
0.35
2.7
1.6
—
—
—
0
0
7
56
1.25
0.29
1.3
1.8
7.76
7.97
u/l
—
7
46
8
64
1.25
0.27
1.4
1.1
—
—
—
0
0
266
2590
1.08
0.27
6.4
5.3
2.06
1.99
mu/l
0.34
242
2329
5
72
0.69
0.26
3.4
1.8
204.80
232.52
pmol/l
—
5
65
95
892
1.08
0.25
5.1
3.9
0.00
0.10
estimate
0.55
31
283
257
2627
0.94
0.23
7.7
6.8
38.86
40.13
mmol/mol
1.23
240
2433
5
38
1.32
0.23
1.2
1.4
—
—
—
0
0
10
79
1.27
0.22
1.4
1.5
3366.00
8200.87
e6/l
—
5
53
201
2067
0.94
0.22
4.9
4.5
—
0.40
—
0
5
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
8
69
1.16
0.16
1.3
1.4
—
—
—
0
0
78
741
1.06
0.16
1.7
1.3
—
—
—
0
0
6
76
0.79
0.15
1.0
1.1
—
—
—
0
0
283
2865
0.95
0.14
30.0
16.1
—
—
—
0
0
5
65
0.77
0.08
1.8
1.1
0.98
0.87
g/l
—
5
65
7
65
1.08
0.08
1.4
1.2
3.84
3.69
mmol/l
—
7
60
7
85
0.82
0.07
1.0
1.1
—
—
—
0
0
26
247
1.05
0.05
4.9
3.2
6.03
6.08
ph
0.10
19
180
10
109
0.91
0.04
1.1
1.1
—
—
—
0
0
24
250
0.96
0.03
2.1
1.5
—
—
—
0
0
25
256
0.97
0.01
1.6
1.5
—
—
—
0
0
37
371
1.00
0.00
1.2
1.4
—
—
—
0
0
10
101
0.99
0.00
3.8
5.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
2.60
—
0
5
0
6
0.00
0.00
0.0
1.2
—
0.00
—
0
6
0
5
0.00
0.00
0.0
1.0
—
0.03
—
0
5
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
19.18
—
0
6
0
8
0.00
0.00
0.0
1.0
—
40.09
—
0
8
0
6
0.00
0.00
0.0
5.3
—
6.70
—
0
6
5
58
0.86
-0.00
1.0
1.4
—
247.14
—
0
28
0
7
0.00
-0.00
0.0
1.6
—
8.86
—
0
7
9
94
0.96
-0.00
2.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint D3_NUTRIANAEMIAOTHER and mortality.

Females

Parameter HR [95% CI] p-value
D3_NUTRIANAEMIAOTHER 2.436 [2.09, 2.84] < 0.001
Birth year 0.992 [0.98, 1.0] 0.076

During the follow-up period (1.1.1998 — 31.12.2019), 1095 out of 1787 females with D3_NUTRIANAEMIAOTHER died.

Males

Parameter HR [95% CI] p-value
D3_NUTRIANAEMIAOTHER 2.566 [2.12, 3.1] < 0.001
Birth year 0.987 [0.98, 1.0] 0.009

During the follow-up period (1.1.1998 — 31.12.2019), 1049 out of 1608 males with D3_NUTRIANAEMIAOTHER died.

Mortality risk

Mortality risk for people of age

years, who have D3_NUTRIANAEMIAOTHER.

N-year risk Females Males
1 0.188% 0.502%
5 1.359% 3.048%
10 3.342% 7.784%
15 6.272% 14.518%
20 10.55% 24.067%

Relationships between endpoints

↥

Index endpoint: D3_NUTRIANAEMIAOTHER – Other nutritional anaemias

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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