No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
258 |
4. Check minimum number of eventsNone |
258 |
5. Include endpointsNone |
258 |
6. Filter based on genotype QC (FinnGen only) |
229 |
Control definitions (FinnGen only)
- Control exclude
- RHEUMA_CHRYSTAL
Extra metadata
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other/unspecified crystal arthropathies
based on the number of shared cases.
Similar with more cases:
- Other crystal arthropathies
- Crystal arthropathies, rheuma endpoint
- Polyarthropathies
- Finngen Rheumatological endpoints
- Arthropathies
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1547 | 864 | 670 |
| Only index persons | 1294 | 716 | 578 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 73.60 | 75.80 | 70.78 |
| Only index persons | 72.74 | 74.85 | 70.12 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 229 | 123 | 106 |
| Unadjusted period prevalence (%) | 0.05 | 0.04 | 0.05 |
| Median age at first event (years) | 72.06 | 71.38 | 72.85 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 237
- Matched controls
- 2370
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M11.9
ICD-10 Finland
Crystal arthropathy, unspecified
+∞
137.2
118
*
M11.8
ICD-10 Finland
Other specified crystal arthropathies
2279.4
133.8
117
*
M13.9
ICD-10 Finland
Arthritis, unspecified
15.3
84.6
90
91
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
5.5
31.5
80
202
M10.9
ICD-10 Finland
Gout, unspecified
6.5
29.3
56
108
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
7.2
27.0
45
75
M11.2
ICD-10 Finland
Other chondrocalcinosis
105.4
26.3
28
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
6.6
20.5
36
63
N02AX02
ATC
tramadol; systemic, rectal
3.6
20.1
153
797
M00.9
ICD-10 Finland
Pyogenic arthritis, unspecified
29.0
19.6
26
10
H02AB06
ATC
prednisolone; systemic
3.6
19.5
162
885
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.1
18.9
65
201
M17.1
ICD-10 Finland
Other primary gonarthrosis
3.2
16.0
97
427
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
3.6
15.8
65
225
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
4.2
15.6
48
136
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.1
14.5
165
1010
X59
ICD-10 Finland
Exposure to unspecified factor
3.2
14.2
72
283
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
4.7
13.5
34
82
NF1AA
NOMESCO Finland
Hip X-ray examination
3.6
13.3
50
162
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
3.1
12.8
70
286
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.4
12.7
53
184
M79.6
ICD-10 Finland
Pain in limb
2.7
12.4
136
794
A46
ICD-10 Finland
Erysipelas
3.0
11.7
64
260
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.7
11.5
85
405
N03AX16
ATC
[U] pregabalin
2.8
11.5
80
370
L15
ICPC
Knee symptom/complaint
2.7
11.4
84
399
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
5.2
11.2
24
50
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
3.6
11.1
40
125
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.9
11.1
68
293
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
4.1
11.0
32
86
L28
ICPC
Limited function/disability (L)
2.7
10.9
83
400
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
5.3
10.0
21
43
N02AJ06
ATC
codeine and paracetamol; systemic
2.4
9.9
124
745
UKC02
NOMESCO Finland
Cystoscopy
2.7
9.6
66
300
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
3.5
9.5
36
116
M10.0
ICD-10 Finland
Idiopathic gout
5.0
9.5
21
45
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.6
9.3
33
102
SPAT1211
SPAT
Application of soft bandage
3.4
9.0
36
120
J01DB01
ATC
cefalexin; oral
3.3
8.9
208
1627
J01FF01
ATC
clindamycin; systemic
2.4
8.9
86
457
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.8
8.8
49
199
L90
ICPC
Osteoarthrosis of knee
3.5
8.8
33
106
NGC00
NOMESCO Finland
Exchange of a loose part of prosthesis in knee joint
52.0
8.7
10
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
8.7
75
378
M19.0
ICD-10 Finland
Primary arthrosis of other joints
2.9
8.3
43
167
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.9
8.3
44
174
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.7
8.1
48
201
AA1AD
NOMESCO Finland
CT of head and brain
2.2
7.9
102
605
L04AX03
ATC
methotrexate; systemic
3.1
7.9
36
130
C03CA01
ATC
furosemide; systemic
2.2
7.9
120
760
NK4AT
NOMESCO Finland
Puncture of joint with ultrasound guidance not elsewher classified
15.7
7.8
12
8
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
4.7
7.6
18
41
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
2.7
7.5
47
202
T84.5
ICD-10 Finland
Infection and inflammatory reaction due to internal joint prosthesis
9.8
7.4
14
15
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.5
7.4
56
264
M25.5
ICD-10 Finland
Pain in joint
2.2
7.4
90
520
M03BX02
ATC
tizanidine; oral
2.1
7.3
144
998
I50.9
ICD-10 Finland
Heart failure, unspecified
2.3
7.0
68
356
ACC51
NOMESCO Finland
Release of median nerve
3.3
7.0
28
93
M54.2
ICD-10 Finland
Cervicalgia
3.2
7.0
30
104
R50.9
ICD-10 Finland
Fever, unspecified
2.5
7.0
50
229
P01BA02
ATC
hydroxychloroquine; oral
3.0
6.9
33
122
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.4
6.9
57
279
NG1AE
NOMESCO Finland
Knee joint ultrasound exmination
9.7
6.9
13
14
J01MA12
ATC
levofloxacin; systemic
2.3
6.9
67
352
A02BC02
ATC
pantoprazole; systemic
2.3
6.8
180
1379
M35.3
ICD-10 Finland
Polymyalgia rheumatica
3.4
6.8
25
79
JN4AD
NOMESCO Finland
Body CT examination
2.6
6.8
42
179
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.5
6.8
47
212
X58
ICD-10 Finland
Exposure to other specified factors
2.6
6.7
44
193
JN3AD
NOMESCO Finland
Abdominal CT examination
2.6
6.7
44
193
H02AB04
ATC
methylprednisolone; systemic
2.5
6.7
48
220
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.0
6.7
105
663
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
3.1
6.6
29
102
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
6.5
90
540
L12
ICPC
Hand/finger symptom/complaint
2.4
6.5
53
257
N11.9
ICD-10 Finland
Chronic tubulo-interstitial nephritis, unspecified
71.7
6.5
7
*
M04AA01
ATC
allopurinol; systemic
2.4
6.5
52
251
N02AA05
ATC
oxycodone; systemic
2.2
6.4
70
384
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.1
6.3
85
504
N19
ICD-10 Finland
Unspecified kidney failure
3.5
6.3
22
67
G56.0
ICD-10 Finland
Carpal tunnel syndrome
2.5
6.3
46
212
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
2.5
6.3
43
192
A11CC03
ATC
alfacalcidol; systemic
6.6
6.3
15
24
NK5AT
NOMESCO Finland
Joint injection with ultrasound guidance not elsewhere classified
27.5
6.3
8
*
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.6
6.3
40
173
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
7.0
6.1
14
21
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.2
6.1
58
301
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.6
6.0
38
163
TK800
NOMESCO Finland
Hemodialysis
7.6
6.0
13
18
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
107
66
28.73
135.53
2.0
1.2
—
—
—
0
0
79
64
18.02
84.80
2.3
1.3
31658.41
24631.24
e6/l
0.19
54
41
156
586
5.86
39.60
3.9
2.8
333.37
353.19
umol/l
1.47
139
503
49
61
9.87
38.18
1.9
1.5
—
—
—
0
0
99
322
4.56
28.15
1.5
1.3
5.18
11.06
u/ml
0.71
40
115
38
53
8.35
26.69
2.2
1.5
—
—
—
0
0
31
18
19.62
20.67
1.5
1.0
69380.26
490562.50
e6/l
0.45
19
12
92
354
3.61
19.52
1.6
1.3
18.53
31.21
iu/ml
1.58
27
118
64
197
4.08
18.76
5.2
3.4
89.49
86.11
ng/l
0.11
52
170
93
382
3.36
17.50
3.4
2.5
19.50
21.50
%
0.93
88
350
35
76
5.23
15.75
2.7
3.3
1.17
3.74
ratio
1.28
21
41
94
413
3.11
15.48
2.7
1.9
—
—
—
0
0
97
434
3.09
15.47
3.6
2.5
10.29
12.29
umol/l
2.66
90
401
59
207
3.46
13.95
2.8
3.1
65.46
66.25
g/l
0.36
54
188
75
309
3.09
13.56
2.2
1.8
—
—
—
0
0
44
132
3.87
13.09
1.9
1.6
—
—
—
0
0
179
1193
3.04
12.66
13.4
6.9
1.22
1.21
mmol/l
0.33
155
1021
167
1088
2.81
12.05
12.0
6.2
1.21
1.21
mmol/l
0.09
156
994
114
632
2.55
11.24
3.0
2.3
3.49
3.06
mg/l
0.52
95
545
73
330
2.75
10.86
10.7
4.9
1.05
1.03
mmol/l
0.17
67
301
172
1202
2.57
9.69
14.1
9.3
4.65
4.28
e9/l
1.12
148
1052
200
1511
3.07
9.54
8.8
4.7
20.91
14.10
mm/h
5.19
192
1398
147
965
2.38
9.40
3.5
2.5
77.59
78.77
nmol/l
0.21
130
847
64
292
2.63
9.19
2.3
1.9
—
—
—
0
0
143
934
2.34
9.16
4.4
3.0
144.16
127.42
ug/l
0.66
129
851
36
120
3.36
9.04
1.5
1.3
—
—
—
0
0
165
1157
2.40
8.81
7.5
4.6
0.00
6.11
estimate
0.50
43
266
118
724
2.25
8.62
2.8
2.2
147.93
217.36
u/l
0.87
113
685
168
1199
2.38
8.43
9.1
6.5
10.97
11.69
umol/l
0.40
161
1131
162
1141
2.33
8.35
7.6
4.5
0.00
0.00
estimate
-0.00
42
254
141
945
2.21
8.11
7.6
4.5
38.82
99.54
ng/l
0.57
124
736
116
733
2.14
7.60
2.1
1.8
19.16
20.97
nmol/l
0.63
98
607
32
111
3.18
7.51
2.3
1.7
0.34
3.81
ug/l
0.75
27
96
106
651
2.14
7.43
8.2
4.7
0.00
0.01
estimate
0.50
42
235
84
471
2.21
7.42
1.8
1.7
1.41
1.34
mg/l
0.11
70
377
90
522
2.17
7.28
3.2
2.4
—
—
—
0
0
202
1610
2.72
7.28
15.3
8.4
82.24
81.82
u/l
0.04
195
1517
148
1039
2.13
7.22
8.7
4.9
33.52
34.89
g/l
2.37
143
971
43
181
2.68
7.13
2.3
1.6
—
—
—
0
0
161
1171
2.17
7.11
7.7
4.5
0.00
0.02
estimate
0.50
41
247
147
1036
2.10
7.01
2.6
2.2
100.53
94.60
pmol/l
0.59
80
533
26
84
3.35
6.82
1.8
1.5
3.98
10.13
iu/ml
—
6
23
19
50
4.04
6.68
1.5
1.2
—
—
—
0
0
22
65
3.63
6.60
1.6
1.5
—
—
—
0
0
138
969
2.02
6.43
3.5
2.6
—
—
—
0
0
31
118
2.87
6.19
1.7
1.8
1.60
1.57
g/l
0.04
25
104
119
809
1.95
5.92
4.7
3.5
2.35
2.36
mmol/l
0.16
111
726
16
41
4.11
5.81
1.7
1.6
—
—
—
0
0
24
82
3.14
5.76
1.8
2.7
—
—
—
0
0
21
66
3.39
5.75
1.7
1.5
—
—
—
0
0
109
725
1.93
5.74
3.8
2.5
70.15
69.88
u/l
0.01
103
675
137
986
1.92
5.66
3.6
2.9
—
—
estimate
—
0
0
104
688
1.91
5.51
6.4
3.5
0.31
0.37
e6/l
0.27
85
518
16
43
3.92
5.46
1.6
1.6
—
—
—
0
0
157
1192
1.94
5.41
4.9
3.3
69.73
51.60
u/l
0.96
147
1104
49
251
2.20
5.23
4.9
3.8
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
21
71
3.15
5.13
2.0
2.3
0.47
0.41
iu/ml
—
10
42
83
520
1.92
5.11
3.3
3.2
2.50
2.47
mmol/l
1.35
72
462
16
46
3.66
4.99
1.6
1.5
—
—
—
0
0
17
52
3.44
4.85
1.5
1.6
—
—
—
0
0
214
1855
2.58
4.72
36.1
19.4
69.63
73.39
ml/min/173m2
1.53
201
1748
119
853
1.79
4.66
5.0
3.5
1606.75
1598.75
ng/l
0.01
106
746
219
1924
2.82
4.61
42.3
19.3
30.17
25.64
mg/l
1.38
211
1644
22
82
2.86
4.56
1.3
1.2
—
—
—
0
0
22
82
2.86
4.56
2.0
2.3
36.72
39.92
u/l
0.34
22
73
109
769
1.77
4.45
4.9
4.1
16.12
9.37
mg/mmol
0.48
73
493
21
78
2.86
4.38
4.8
2.4
1.66
1.73
mg/l
0.18
21
66
73
461
1.84
4.28
2.2
1.7
1428.12
1233.34
nmol/l
0.73
53
352
20
74
2.86
4.20
1.8
2.1
0.00
0.00
g/l
-0.00
20
68
9
13
7.15
4.20
1.6
1.4
—
—
—
0
0
8
10
8.23
4.09
1.6
1.3
—
—
—
0
0
8
10
8.23
4.09
1.6
1.3
—
—
—
0
0
7
7
10.25
4.03
1.3
1.3
273.03
126.86
iu/ml
—
7
7
14
37
3.96
3.97
1.4
1.6
—
—
—
0
0
19
71
2.82
3.93
2.3
1.7
—
—
—
0
0
39
204
2.09
3.92
3.0
2.7
32.47
29.08
u/l
0.26
30
165
21
83
2.68
3.92
2.2
2.0
—
—
—
0
0
49
279
1.95
3.91
6.2
5.3
32.24
32.44
%
0.04
34
173
77
507
1.77
3.88
2.0
1.8
436.81
28676922.95
pmol/l
0.50
58
408
15
49
3.20
3.88
1.7
2.4
13.47
12.01
mg/l
0.35
15
44
20
79
2.67
3.74
1.9
1.9
—
—
—
0
0
27
124
2.33
3.71
4.5
3.0
1.14
1.51
mmol/l
0.23
21
91
20
81
2.60
3.57
4.2
2.5
23.24
24.58
mmol/l
0.74
20
81
43
242
1.95
3.53
7.0
3.3
1.48
1.80
mmol/l
0.29
38
200
12
32
3.89
3.44
1.8
1.3
—
—
—
0
0
13
43
3.14
3.30
1.8
2.1
32.69
32.47
pg
0.07
13
43
49
296
1.83
3.24
9.3
6.6
0.71
0.88
mmol/l
0.11
41
250
58
373
1.73
3.11
2.5
1.9
30.36
29.66
s
0.25
58
363
42
245
1.87
3.10
3.7
2.6
7.12
7.72
umol/l
0.09
33
212
6
8
7.66
3.07
3.2
1.4
94.33
101.63
%
—
6
8
12
36
3.46
3.06
1.9
1.3
—
—
—
0
0
7
12
5.97
3.04
1.7
2.3
—
—
—
0
0
9
22
4.21
2.91
8.2
3.6
807.00
952.18
mg
—
9
22
8
18
4.56
2.82
2.3
1.3
—
—
—
0
0
61
415
1.63
2.62
6.2
3.2
1.85
1.09
e6/l
0.39
35
229
36
212
1.82
2.58
5.1
2.9
4.43
4.17
kpa
0.36
36
202
41
252
1.76
2.55
7.3
3.3
5.82
5.76
kpa
0.16
41
241
10
31
3.32
2.55
2.2
4.2
—
—
—
0
0
9
27
3.42
2.42
1.3
1.3
—
—
—
0
0
9
27
3.42
2.42
1.3
1.3
—
—
—
0
0
217
1998
2.02
2.41
23.1
13.2
23.55
24.12
u/l
0.21
210
1933
5
8
6.35
2.38
1.2
2.8
36.12
42.55
g/l
—
5
8
7
17
4.21
2.38
1.3
1.4
—
—
—
0
0
14
60
2.42
2.26
2.9
2.6
7.48
8.01
kpa
0.61
14
60
172
1504
1.52
2.19
4.9
4.5
15.56
15.09
pmol/l
1.39
154
1339
7
19
3.76
2.16
1.3
1.8
—
—
—
0
0
7
19
3.76
2.16
1.3
1.8
—
—
—
0
0
7
19
3.76
2.16
1.3
1.8
—
—
—
0
0
12
49
2.53
2.14
1.3
1.4
—
—
—
0
0
14
62
2.34
2.12
1.4
1.3
—
—
—
0
0
13
56
2.40
2.09
1.1
1.1
—
—
—
0
0
219
2044
1.94
1.99
57.7
29.0
92.28
91.64
fl
1.25
219
2021
7
21
3.40
1.98
4.3
1.6
1.63
0.97
mmol/l
—
7
21
219
2045
1.93
1.98
57.9
29.0
4.24
4.39
e12/l
3.94
214
1995
219
2045
1.93
1.98
58.3
29.3
127.17
132.45
g/l
5.81
219
2020
219
2045
1.93
1.98
59.4
29.5
38.76
39.74
%
2.75
219
2020
15
71
2.19
1.97
4.9
3.3
24.26
24.87
mmol/l
0.45
15
64
8
27
3.03
1.95
1.3
1.3
—
—
—
0
0
8
27
3.03
1.95
1.4
1.3
—
—
—
0
0
8
27
3.03
1.95
1.4
1.3
—
—
—
0
0
5
11
4.62
1.95
3.2
2.0
82.88
61.57
ug/l
—
5
11
61
443
1.51
1.95
1.3
1.3
0.68
1.45
u/ml
1.34
14
118
107
867
1.43
1.94
8.8
4.7
0.08
0.02
estimate
0.30
39
215
7
22
3.25
1.89
1.1
1.7
—
—
—
0
0
8
28
2.92
1.88
1.4
1.3
—
—
—
0
0
6
17
3.59
1.85
1.5
1.4
120.33
92.82
pmol/l
—
6
17
12
53
2.33
1.84
2.0
1.6
—
—
—
0
0
5
12
4.23
1.83
1.0
1.0
—
—
—
0
0
35
228
1.63
1.78
3.3
2.7
4.40
7.72
ug/l
0.93
30
197
6
18
3.39
1.76
1.2
1.4
—
—
—
0
0
14
68
2.13
1.74
1.4
1.3
—
—
—
0
0
7
24
2.97
1.73
1.1
1.7
—
—
—
0
0
5
13
3.90
1.72
1.2
2.0
—
—
—
0
0
5
13
3.90
1.72
1.2
2.0
—
—
—
0
0
54
394
1.48
1.68
6.7
3.3
2.19
2.14
e6/l
0.02
29
211
6
19
3.21
1.67
2.0
1.7
—
—
—
0
0
6
19
3.21
1.67
1.2
1.4
—
—
—
0
0
6
19
3.21
1.67
1.2
1.3
—
—
—
0
0
6
19
3.21
1.67
1.2
1.4
—
—
—
0
0
6
19
3.21
1.67
7.8
2.2
—
—
—
0
0
197
1811
1.52
1.62
6.6
5.7
2.01
2.05
mu/l
0.15
184
1634
81
646
1.39
1.54
7.5
3.8
0.00
0.00
estimate
-0.00
33
207
27
171
1.65
1.54
4.3
3.3
61.58
58.81
ml/min/173m2
0.09
12
79
201
1861
1.53
1.54
9.6
7.3
41.51
40.25
mmol/mol
0.95
189
1725
38
262
1.54
1.54
11.0
8.7
—
—
—
0
0
5
16
3.17
1.44
1.4
1.3
—
—
—
0
0
10
46
2.23
1.42
2.2
1.5
—
—
—
0
0
10
46
2.23
1.42
2.2
1.5
—
—
—
0
0
13
67
1.99
1.41
1.5
1.5
267.67
272.32
ug/g
—
6
38
133
1496
0.75
1.40
53.1
25.8
326.79
330.95
g/l
4.69
133
1486
6
23
2.65
1.37
1.2
1.3
—
—
—
0
0
6
24
2.54
1.31
1.2
1.3
—
—
—
0
0
6
25
2.44
1.25
1.3
1.6
—
—
—
0
0
5
19
2.67
1.22
2.2
4.3
0.80
0.74
%
—
5
19
21
135
1.61
1.16
5.4
2.6
0.56
0.66
%
0.80
21
135
7
31
2.30
1.11
1.0
1.5
—
—
—
0
0
7
32
2.22
1.09
2.1
1.3
0.79
0.87
g/l
—
7
32
19
122
1.61
1.06
5.8
3.3
24.53
24.88
mmol/l
0.19
19
117
9
46
1.99
1.05
3.7
2.7
8.59
9.85
pmol/l
—
9
46
7
34
2.09
1.03
1.6
1.2
—
—
—
0
0
202
1910
1.39
1.00
7.0
6.5
2.45
2.54
mmol/l
0.81
182
1740
199
1878
1.37
0.99
6.8
5.8
6.12
6.09
mmol/l
0.10
181
1702
21
141
1.54
0.99
6.8
3.8
51.17
45.36
%
0.49
21
135
7
36
1.97
0.98
1.6
1.2
—
—
—
0
0
8
42
1.94
0.89
1.4
1.3
—
—
—
0
0
8
45
1.80
0.85
1.3
1.2
13.01
21.09
u/l
—
8
38
18
123
1.50
0.80
2.5
4.1
1.75
1.48
%
0.34
18
117
5
24
2.11
0.75
1.0
1.8
—
—
—
0
0
5
24
2.11
0.75
1.0
1.1
—
—
—
0
0
7
39
1.82
0.73
2.1
1.9
—
—
—
0
0
86
757
1.21
0.71
7.6
6.1
3.39
2.68
ug/l
0.21
77
669
7
117
0.59
0.70
3.3
2.1
3.40
3.41
ratio
—
7
99
5
94
0.52
0.68
1.0
1.1
—
—
—
0
0
194
1853
1.26
0.66
6.5
5.5
1.44
1.46
mmol/l
0.28
177
1680
195
1865
1.26
0.64
6.5
5.6
4.32
4.45
mmol/l
0.98
177
1701
53
450
1.23
0.62
3.8
3.4
0.60
0.87
ug/l
2.33
40
309
5
30
1.68
0.62
1.4
1.2
1.30
1.57
g/l
—
5
30
24
186
1.32
0.57
1.6
1.4
—
—
—
0
0
6
36
1.68
0.57
1.7
1.7
—
—
—
0
0
12
84
1.45
0.50
1.3
1.2
—
—
—
0
0
15
112
1.36
0.46
1.1
1.3
164.69
547.41
u/ml
0.83
15
104
163
1553
1.16
0.46
44.4
24.5
14.41
13.91
%
3.61
163
1539
10
70
1.45
0.42
1.3
1.1
—
—
—
0
0
10
70
1.45
0.42
1.3
1.1
—
—
—
0
0
12
88
1.38
0.41
1.7
1.6
—
—
—
0
0
183
1769
1.15
0.37
5.6
4.6
1.36
1.27
mmol/l
0.90
163
1591
5
80
0.62
0.36
3.2
1.9
3.24
3.50
mmol/l
—
5
60
24
200
1.22
0.35
2.5
3.2
154.16
221.01
ng/l
0.91
19
185
66
601
1.14
0.35
4.2
5.1
19.22
21.51
%
0.91
36
308
11
82
1.36
0.34
1.5
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
53
492
1.10
0.21
9.5
5.3
1.02
1.02
kg/l
1.25
36
342
14
164
0.84
0.19
3.9
2.3
10.32
12.96
nmol/l
0.55
14
149
7
60
1.17
0.18
1.6
1.6
—
—
—
0
0
86
826
1.06
0.15
1.9
2.0
1.31
1.31
mmol/l
0.01
70
666
13
124
1.05
0.00
5.7
4.4
1.02
1.02
ratio
0.07
13
119
22
226
0.97
0.00
1.4
1.4
—
—
—
0
0
23
234
0.98
0.00
1.6
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
2.4
—
13.81
—
0
7
0
6
0.00
-0.00
0.0
1.5
—
13.00
—
0
6
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
9.56
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
38.58
—
0
8
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint CHRYSTAL_NOS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHRYSTAL_NOS | 1.612 [1.3, 2.0] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.049 |
During the follow-up period (1.1.1998 — 31.12.2019), 301 out of 641 females with CHRYSTAL_NOS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHRYSTAL_NOS | 1.755 [1.31, 2.36] | < 0.001 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 218 out of 482 males with CHRYSTAL_NOS died.
Mortality risk
Mortality risk for people of age
years, who have CHRYSTAL_NOS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.143% | 0.325% |
| 5 | 0.84% | 1.923% |
| 10 | 2.169% | 4.736% |
| 15 | 4.007% | 8.626% |
| 20 | 7.146% | 14.061% |
Relationships between endpoints
↥Index endpoint: CHRYSTAL_NOS – Other/unspecified crystal arthropathies
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data