primary biliary cirrhosis: Primary biliary cholangitis (PBC) is a chronic and slowly progressive cholestatic liver disease of autoimmune etiology characterized by injury of the intrahepatic bile ducts that may eventually lead to liver failure.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
924 |
4. Check minimum number of eventsNone |
924 |
5. Include endpointsNone |
924 |
6. Filter based on genotype QC (FinnGen only) |
826 |
Control definitions (FinnGen only)
- Control exclude
- AUTOIMMUNE
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- K74
- Name in latin
- Cirrhosis biliaris [primaria]
Similar endpoints
↥List of similar endpoints to
Primary biliary cholangitis (PBC)
based on the number of shared cases.
Similar with more cases:
- Fibrosis and cirrhosis of liver
- Diseases of liver
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Gastrointestinal diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4570 | 3617 | 916 |
| Only index persons | 3977 | 3212 | 765 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.10 | 0.03 |
| Only index persons | 0.10 | 0.12 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 60.86 | 60.40 | 62.52 |
| Only index persons | 59.55 | 59.08 | 61.56 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 826 | 677 | 149 |
| Unadjusted period prevalence (%) | 0.21 | 0.24 | 0.07 |
| Median age at first event (years) | 57.99 | 56.73 | 63.72 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 864
- Matched controls
- 8640
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
115.3
312.8
160
17
A05AA02
ATC
ursodeoxycholic acid; oral
2491.6
307.7
772
29
K74.3
ICD-10 Finland
Primary biliary cirrhosis
+∞
307.7
864
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
228.1
307.7
669
128
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
86.7
307.7
349
67
A07EA06
ATC
budesonide; oral, local oral
49.9
306.9
182
46
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
13.8
298.3
349
405
L04AX01
ATC
azathioprine; systemic
73.6
270.0
147
24
K76.9
ICD-10 Finland
Liver disease, unspecified
38.5
230.0
145
45
K83.0
ICD-10 Finland
Cholangitis
30.9
175.8
118
44
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
34.9
158.7
102
33
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
57.3
146.4
83
16
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
15.5
140.3
129
97
H03AA01
ATC
levothyroxine sodium; systemic
8.3
139.0
214
331
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
6.1
121.1
268
595
L04AA06
ATC
mycophenolic acid; systemic
38.4
119.0
74
21
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
58.5
115.2
65
12
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.8
114.2
461
1673
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
47.6
112.0
66
15
127
Kela drug reimbursment
Transplant complication
36.2
110.7
70
21
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
7.1
106.3
183
315
A07EC02
ATC
mesalazine; oral, rectal
20.0
104.1
82
45
L04AD01
ATC
ciclosporin; systemic
36.4
96.8
61
18
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
12.1
89.9
94
86
P01BA02
ATC
hydroxychloroquine; oral
9.8
89.4
110
127
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
323.6
87.4
87
*
C10AC01
ATC
colestyramine; oral
11.8
84.9
90
84
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.9
84.8
501
2261
L04AD02
ATC
tacrolimus; systemic
46.1
80.9
48
11
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
15.5
77.5
69
48
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
+∞
77.3
73
*
D97
ICPC
Liver disease NOS
41.4
77.2
47
12
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
10.5
75.7
87
91
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
12.0
72.8
76
69
Z94.4
ICD-10 Finland
Liver transplant status
190.1
68.1
70
*
K74.5
ICD-10 Finland
Biliary cirrhosis, unspecified
353.1
66.5
66
*
K51.5
ICD-10 Finland
Left sided colitis
342.5
63.3
63
*
R94.5
ICD-10 Finland
Abnormal results of liver function studies
14.7
59.2
54
39
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
214.6
58.8
60
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
7.6
58.2
87
126
JJC00
NOMESCO Finland
Allogenic transplantation of liver
210.8
57.8
59
*
UJF32
NOMESCO Finland
Coloscopy
3.2
57.0
332
1406
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
21.5
56.9
43
21
K73.9
ICD-10 Finland
Chronic hepatitis, unspecified
203.1
55.7
57
*
UJK02
NOMESCO Finland
ERCP
9.1
54.3
69
82
UJF30
NOMESCO Finland
Ileoscopy through colon
4.1
53.1
168
477
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
8.4
53.0
72
93
R74.8
ICD-10 Finland
Abnormal levels of other serum enzymes
6.9
50.4
82
130
K75.4
ICD-10 Finland
Autoimmune hepatitis
+∞
48.4
46
*
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
108.3
47.3
51
5
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
9.2
46.6
58
67
C03DA01
ATC
spironolactone; oral
3.6
44.8
176
576
TJJ00
NOMESCO Finland
Percutaneous needle biopsy of liver
75.5
44.5
50
7
5716A
ICD-9 Finland
Chronic liver disease and cirrhosis, Biliary cirrhosis[CIRRHOSIS BILIARIS PRIMARIA]
+∞
44.1
42
*
C10AB05
ATC
fenofibrate; oral
10.0
43.7
51
54
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
449.3
43.6
43
*
JL5SB
NOMESCO Finland
Endoscopic retrograd cholangiopancreaticography
10.1
40.7
47
49
E03
ICD-10 Finland
Other hypothyroidism
9.8
36.5
43
46
JN1BG
NOMESCO Finland
MRI examination of upper part of abodmen with high intensity magnet
12.0
36.3
37
32
M34.1
ICD-10 Finland
CR(E)ST syndrome
+∞
35.7
34
*
H02AB06
ATC
prednisolone; systemic
2.4
34.8
467
2839
M05BA04
ATC
alendronic acid; oral
3.4
34.3
143
481
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.4
33.7
476
2944
104
Kela drug reimbursment
Thyroid insufficiency
6.1
33.6
60
104
A10AB05
ATC
insulin aspart; parenteral
5.0
33.1
74
158
K50.8
ICD-10 Finland
Other Crohn disease
+∞
32.5
31
*
T89
ICPC
Diabetes insulin dependent
10.4
32.0
36
36
ZX120
NOMESCO Finland
Intravenous
3.4
30.3
121
395
L88
ICPC
Rheumatoid/seropositive arthritis
10.7
29.9
33
32
TPH04
NOMESCO Finland
Cathetrisation of vein
2.5
29.8
245
1181
JJ5AT, ,
NOMESCO Finland
301.7
28.9
29
*
K51.8
ICD-10 Finland
Other ulcerative colitis
301.7
28.9
29
*
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
57.1
28.3
33
6
C03CA01
ATC
furosemide; systemic
2.3
28.1
302
1631
K51.3
ICD-10 Finland
Ulcerative (chronic) rectosigmoiditis
+∞
27.2
26
*
N02AX02
ATC
tramadol; systemic, rectal
2.2
26.7
423
2658
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
+∞
26.2
25
*
I73.0
ICD-10 Finland
Raynaud syndrome
7.7
26.0
37
50
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
3.4
26.0
103
334
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
4.6
25.5
63
146
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
9.1
25.2
31
35
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
4.4
25.0
66
161
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
72.1
24.9
28
*
TK800
NOMESCO Finland
Hemodialysis
9.6
24.5
29
31
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
22.7
24.5
35
16
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
6.3
24.4
42
70
L04AA01
ATC
[U] ciclosporin
32.1
23.8
31
10
L01BB02
ATC
mercaptopurine; oral
89.3
23.8
26
*
R18
ICD-10 Finland
Ascites
5.7
22.9
43
78
JJA20
NOMESCO Finland
Open biopsy of liver
41.3
22.8
28
7
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
236.0
22.7
23
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
46.3
22.5
27
6
D64.9
ICD-10 Finland
Anaemia, unspecified
2.9
22.3
115
434
L04AX03
ATC
methotrexate; systemic
4.8
22.2
51
111
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
53.5
22.2
26
5
A10AC01
ATC
insulin (human); parenteral
4.2
22.2
62
158
J01MA02
ATC
ciprofloxacin; systemic
2.0
21.6
362
2273
JCA22
NOMESCO Finland
Endoscopic ligature of oesophageal varices
28.9
21.0
28
10
K51.0
ICD-10 Finland
Ulcerative (chronic) pancolitis
+∞
20.9
20
*
JKE02
NOMESCO Finland
Transduodenal endoscopic incision of common bile duct orifice
7.4
20.5
30
42
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
2.5
20.3
149
671
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
3.6
20.0
69
204
K50.1
ICD-10 Finland
Crohn disease of large intestine
+∞
19.9
19
*
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
+∞
19.9
19
*
K83.8
ICD-10 Finland
Other specified diseases of biliary tract
107.5
19.6
21
*
A07EC01
ATC
sulfasalazine; oral, rectal
4.9
19.6
44
94
K83.9
ICD-10 Finland
Disease of biliary tract, unspecified
20.6
19.2
28
14
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
6.0
19.0
34
59
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
3.4
18.6
68
209
K90.0
ICD-10 Finland
Coeliac disease
15.5
18.5
30
20
JN3AD
NOMESCO Finland
Abdominal CT examination
2.4
18.5
140
638
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.4
18.3
147
687
H02AB04
ATC
methylprednisolone; systemic
2.3
17.8
147
695
K74.2
ICD-10 Finland
Hepatic fibrosis with hepatic sclerosis
+∞
17.8
17
*
K74.4
ICD-10 Finland
Secondary biliary cirrhosis
+∞
17.8
17
*
107
Kela drug reimbursment
Pernicious anaemia
+∞
17.8
17
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.6
17.5
111
464
E03.89
ICD-10 Finland
Other specified hypothyroidism
7.5
17.5
25
34
A07AA11
ATC
rifaximin; oral
42.9
17.3
21
5
J01MA12
ATC
levofloxacin; systemic
2.2
17.3
178
921
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
4.2
17.3
47
117
A06AD11
ATC
lactulose; oral
2.3
16.6
149
729
UJK12
NOMESCO Finland
Peroral cholangioscopy
173.2
16.5
17
*
A10AE04
ATC
insulin glargine; parenteral
3.0
16.4
78
280
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.7
16.3
95
381
A02BC02
ATC
pantoprazole; systemic
1.9
16.3
631
5037
H02AB07
ATC
prednisone; oral
2.4
16.2
128
593
5761C
ICD-9 Finland
Other disorders of biliary tract, Cholangitis[CHOLANGITIS SCLEROSIVA]
+∞
15.7
15
*
K50.9
ICD-10 Finland
Crohn disease, unspecified
57.7
14.8
17
*
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
14.8
219
1287
XW000
NOMESCO Finland
Bone marrow biopsy
3.7
14.8
48
136
R50.9
ICD-10 Finland
Fever, unspecified
2.2
14.7
135
664
K74.0
ICD-10 Finland
Hepatic fibrosis
25.5
14.7
20
8
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.4
14.6
110
497
A10AB01
ATC
insulin (human); parenteral
12.1
14.6
26
22
K50.0
ICD-10 Finland
Crohn disease of small intestine
+∞
14.6
14
*
I85.0
ICD-10 Finland
Oesophageal varices with bleeding
27.7
14.3
19
7
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.2
14.3
58
190
R17
ICD-10 Finland
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
6.5
14.2
23
36
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.6
14.1
89
371
R4190
NOMESCO Finland
Nutritional therapy
3.7
14.0
45
127
JKE32
NOMESCO Finland
Endoscopic dilatation of bile duct
30.6
13.9
18
6
WX002
NOMESCO Finland
Sedation and analgesia
2.0
13.9
188
1069
C08CA05
ATC
nifedipine; systemic
3.0
13.8
61
210
JA2AT
NOMESCO Finland
Abdominal puncture with ultrasound guidance
10.7
13.8
26
25
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.3
13.8
52
163
M34.9
ICD-10 Finland
Systemic sclerosis, unspecified
+∞
13.6
13
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.0
13.5
63
224
XQ841
NOMESCO Finland
Examination of dermatosis with microscope
142.2
13.5
14
*
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
142.2
13.5
14
*
Z2221
NOMESCO Finland
Medical doctor
1.8
13.4
255
1617
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.8
13.4
263
1685
JL5CG
NOMESCO Finland
Extensive MRI examinaiton of bile and pancreas ducts with high intesity magnet
10.7
13.3
25
24
M81.9
ICD-10 Finland
Osteoporosis, unspecified
2.8
13.2
66
244
K72.9
ICD-10 Finland
Hepatic failure, unspecified
15.3
13.1
21
14
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
3.1
13.0
55
185
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.9
13.0
211
1273
TGC00
NOMESCO Finland
Bronchial lavation
4.8
12.9
29
62
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
50.8
12.9
15
*
JJ3AT
NOMESCO Finland
Cytology of liver with ultrasound guidance
50.8
12.9
15
*
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
50.8
12.9
15
*
E0000UV, ,
ATC
1.7
12.9
362
2562
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.9
12.8
209
1263
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
12.7
234
1465
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
12.7
327
2257
L04AA05
ATC
[U] tacrolimus
70.9
12.6
14
*
L01BA01
ATC
methotrexate; systemic
32.6
12.6
16
5
J01FF01
ATC
clindamycin; systemic
1.8
12.5
239
1512
K75.3
ICD-10 Finland
Granulomatous hepatitis, not elsewhere classified
+∞
12.5
12
*
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.6
12.5
42
122
A07EA02
ATC
hydrocortisone; rectal
13.4
12.5
21
16
6611
FHL
Needle biopsy in the operating room
131.9
12.5
13
*
A41.9
ICD-10 Finland
Sepsis, unspecified
3.8
12.3
38
104
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.2
12.2
48
154
A10AE05
ATC
insulin detemir; parenteral
3.8
12.2
37
100
E10
ICD-10 Finland
Type 1 diabetes mellitus
27.1
12.1
16
6
A10AA01, ,
ATC
21.6
12.0
17
8
H02AB09
ATC
hydrocortisone; systemic
4.9
12.0
26
54
JN4AD
NOMESCO Finland
Body CT examination
2.2
11.8
113
564
A06AC01
ATC
ispaghula (psylla seeds); oral
1.7
11.7
258
1698
K73.0
ICD-10 Finland
Chronic persistent hepatitis, not elsewhere classified
65.9
11.6
13
*
A10AB04
ATC
insulin lispro; parenteral
10.2
11.5
22
22
1300
FHL
Esophagogastroduodenoscopy (also includes staining)
13.8
11.5
19
14
PC2DE
NOMESCO Finland
Ultrasound examination of liver vasculature with Doppler method
+∞
11.5
11
*
K51.2
ICD-10 Finland
Ulcerative (chronic) proctitis
+∞
11.5
11
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.0
11.5
148
824
K29.3
ICD-10 Finland
Chronic superficial gastritis
3.4
11.3
40
120
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
15.3
11.3
18
12
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.9
11.3
164
949
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
2.1
11.3
121
631
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.9
11.1
164
955
A46
ICD-10 Finland
Erysipelas
2.0
11.0
121
636
K51
ICD-10 Finland
Ulcerative colitis
43.9
10.9
13
*
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
9.0
10.8
22
25
K83.1
ICD-10 Finland
Obstruction of bile duct
4.5
10.8
26
59
A07AA09
ATC
vancomycin; oral
5.7
10.7
20
36
XPX08
NOMESCO Finland
Intraoperative flow measurement
11.4
10.6
19
17
B03BA03
ATC
hydroxocobalamin; parenteral
3.3
10.5
40
126
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
3.0
10.5
46
158
5714X
ICD-9 Finland
Chronic liver disease and cirrhosis, Chronic hepatitis[HEPATITIS CHRONICA ALIA SEU NUD]
+∞
10.4
10
*
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
+∞
10.4
10
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
7.8
10.4
23
30
A10AA02, ,
ATC
8.3
10.4
22
27
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.1
10.3
42
138
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.3
10.3
81
373
O99.6
ICD-10 Finland
Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
23.7
10.3
14
6
K72.1
ICD-10 Finland
Chronic hepatic failure
23.7
10.3
14
6
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
4.2
10.2
27
66
ZXE00
NOMESCO Finland
One hour or less
1.6
10.2
331
2393
XG410
NOMESCO Finland
Flow-volume spirometry
3.1
10.1
43
145
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
10.1
406
3088
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.9
10.0
135
761
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
3.2
9.8
38
121
M81.4
ICD-10 Finland
Drug-induced osteoporosis
26.4
9.8
13
5
JKE22
NOMESCO Finland
Endoscopic extraction of foreign body from bile duct
20.3
9.8
14
7
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.3
9.8
36
111
Z3231
NOMESCO Finland
Registered nurse
1.7
9.8
228
1513
B81
ICPC
Anaemia vit B12/folate deficiency
3.7
9.6
30
83
M05BX04
ATC
denosumab; parenteral
2.3
9.5
72
326
5719X
ICD-9 Finland
Chronic liver disease and cirrhosis, Unspecified chronic liver disease without mention of alcohol
101.1
9.4
10
*
L04AB04
ATC
adalimumab; parenteral
30.4
9.4
12
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.6
9.4
342
2529
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
+∞
9.4
9
*
JX1XE
NOMESCO Finland
Other ultrasound examinaton of alimentary organs
+∞
9.4
9
*
H20.1
ICD-10 Finland
Chronic iridocyclitis
+∞
9.4
9
*
56310
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Ulcerative colitis
+∞
9.4
9
*
B07.9
ICD-10 Finland
Verruca simplex
3.2
9.3
37
120
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.7
9.3
48
181
WX892
NOMESCO Finland
Monitored bed care
2.4
9.2
65
285
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.5
9.2
56
229
Z94.0
ICD-10 Finland
Kidney transplant status
13.9
9.2
15
11
M13.9
ICD-10 Finland
Arthritis, unspecified
2.4
9.1
61
261
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.1
9.1
90
454
K52.88
ICD-10 Finland
Other specified noninfective gastroenteritis and colitis
4.1
9.1
25
63
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
15.8
9.0
14
9
JJA21
NOMESCO Finland
Laparoscopic biopsy of liver
37.1
9.0
11
*
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
3.3
9.0
33
102
57309
ICD-8 Finland
Other diseases of liver, Unspecified
24.3
8.9
12
5
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
6.9
8.9
21
31
M81.8
ICD-10 Finland
Other osteoporosis
5.0
8.9
19
39
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
3.2
8.8
35
114
5739X
ICD-9 Finland
Other disorders of liver, Unspecified disorder of liver
50.5
8.7
10
*
K92.0
ICD-10 Finland
Haematemesis
3.8
8.7
26
70
XX9XE
NOMESCO Finland
Other ultrasound examination
16.5
8.6
13
8
C22.0
ICD-10 Finland
Malignant neoplasm: Liver cell carcinoma
10.2
8.5
16
16
TPH07
NOMESCO Finland
Cathetrisation of artery
2.0
8.5
98
523
ZXE40
NOMESCO Finland
More than seven and less than nine hours
3.7
8.5
26
71
JKD20
NOMESCO Finland
Anastomosis of bile duct to jejunum
90.9
8.4
9
*
JJC60
NOMESCO Finland
Total excision of transplanted liver
90.9
8.4
9
*
K80.5
ICD-10 Finland
Calculus of bile duct without cholangitis or cholecystitis
3.4
8.4
30
91
R06.0
ICD-10 Finland
Dyspnoea
1.6
8.4
230
1582
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
12.9
8.4
14
11
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.8
8.4
153
945
N02AA05
ATC
oxycodone; systemic
1.7
8.4
159
994
M34.0
ICD-10 Finland
Progressive systemic sclerosis
+∞
8.3
8
*
H3600, E103,
ICD-10 Finland
+∞
8.3
8
*
391
Kela drug reimbursment
Obeticholic acid
+∞
8.3
8
*
5562A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) proctitis
+∞
8.3
8
*
WX872
NOMESCO Finland
Intensive care
2.7
8.3
43
162
D07AC01
ATC
betamethasone; topical
1.6
8.3
295
2157
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
2.1
8.2
78
387
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
14.6
8.2
13
9
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.0
8.1
86
445
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
22.3
8.0
11
5
A63.0
ICD-10 Finland
Anogenital (venereal) warts
3.2
8.0
31
99
A10AE06
ATC
insulin degludec; parenteral
4.0
7.9
22
56
L40.0
ICD-10 Finland
Psoriasis vulgaris
7.9
7.9
17
22
M79.0
ICD-10 Finland
Rheumatism, unspecified
2.8
7.9
38
138
WX882
NOMESCO Finland
High dependency care
3.6
7.9
25
70
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
2.6
7.8
46
186
K72.0
ICD-10 Finland
Acute and subacute hepatic failure
15.2
7.7
12
8
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.8
7.7
127
761
D07AD01
ATC
clobetasol; topical
1.7
7.7
144
895
1370
FHL
Colonoscopy, whole colon
18.5
7.6
11
6
M05BB03
ATC
alendronic acid and colecalciferol; oral
3.2
7.6
29
92
UJF14
NOMESCO Finland
Enteroscopy of ileoanal anastomosis
25.3
7.6
10
*
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
4.2
7.6
20
49
I50.9
ICD-10 Finland
Heart failure, unspecified
1.9
7.5
101
567
M05BA07
ATC
risedronic acid; oral
2.8
7.5
37
136
WVA20
NOMESCO Finland
Medicine administration
3.1
7.5
31
103
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
4.3
7.5
19
45
A11CC03
ATC
alfacalcidol; systemic
4.0
7.5
21
54
M01CB01
ATC
sodium aurothiomalate; parenteral
80.8
7.4
8
*
L95
ICPC
Osteoporosis
2.4
7.3
49
210
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
3.7
7.3
23
64
A05AA04
ATC
obeticholic acid; oral
+∞
7.3
7
*
H3603, E103,
ICD-10 Finland
+∞
7.3
7
*
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
3.0
7.2
32
111
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.6
7.2
40
157
K75.2
ICD-10 Finland
Nonspecific reactive hepatitis
30.3
7.2
9
*
H04.10
ICD-10 Finland
Dry eye syndrome
1.8
7.2
113
668
K80.3
ICD-10 Finland
Calculus of bile duct with cholangitis
8.0
7.1
15
19
NH3EA
NOMESCO Finland
Feet X-ray examination with load
5.7
7.1
19
34
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.6
7.1
168
1111
K29.7
ICD-10 Finland
Gastritis, unspecified
2.7
7.0
38
147
JKE18
NOMESCO Finland
Endoscopic internal drainage of bile duct
7.1
7.0
16
23
Z2446
NOMESCO Finland
Social worker
2.2
7.0
56
260
R04.0
ICD-10 Finland
Epistaxis
2.1
7.0
64
314
A02BC03
ATC
lansoprazole; oral
1.5
6.9
244
1767
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.6
6.9
171
1143
A07AA02
ATC
nystatin; oral
2.2
6.8
56
263
ZX108
NOMESCO Finland
Inhalation
9.4
6.8
13
14
WX419
NOMESCO Finland
Other general anesthesy
6.2
6.8
17
28
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
2.5
6.8
40
162
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
40.4
6.8
8
*
Z94.9
ICD-10 Finland
Transplanted organ and tissue status, unspecified
40.4
6.8
8
*
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
40.4
6.8
8
*
A41.8
ICD-10 Finland
Other specified sepsis
3.9
6.7
19
49
ZXE20
NOMESCO Finland
More than three and less than five hours
1.8
6.7
106
627
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
3.1
6.7
27
89
K11.71
ICD-10 Finland
Xerostomy (dry mouth)
6.5
6.7
16
25
K86.2
ICD-10 Finland
Cyst of pancreas
4.1
6.6
18
45
N18.8
ICD-10 Finland
Other chronic renal failure
4.1
6.6
18
45
M81.0
ICD-10 Finland
Postmenopausal osteoporosis
2.4
6.5
45
196
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
3.7
6.5
20
55
R4110
NOMESCO Finland
Physiotherapy
1.5
6.5
239
1744
C07AG02
ATC
carvedilol; oral
2.3
6.5
50
229
Z3226
NOMESCO Finland
Physiotherapist
1.6
6.4
150
986
QC6S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in hand
70.4
6.4
7
*
57198
ICD-8 Finland
Cirrhosis of liver, Alia definita, alcoholismo non indicato
70.4
6.4
7
*
57308
ICD-8 Finland
Other diseases of liver, Alii definiti
70.4
6.4
7
*
T86
ICPC
Hypothyroidism/myxoedema
3.8
6.4
19
51
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
6.6
6.4
15
23
SBA10
NOMESCO Finland
Measurement of salivary flow rate
6.6
6.4
15
23
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
6.0
6.3
16
27
WW200
NOMESCO Finland
Immunization
3.4
6.3
22
66
5BA08, ,
NOMESCO Finland
11.1
6.3
11
10
P01AB01
ATC
metronidazole; oral, rectal
1.4
6.3
351
2777
D51.9
ICD-10 Finland
Vitamin B12deficiency anaemia, unspecified
18.2
6.3
9
5
5561A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) ileocolitis
+∞
6.3
6
*
K74.1
ICD-10 Finland
Hepatic sclerosis
+∞
6.3
6
*
D59.1
ICD-10 Finland
Other autoimmune haemolytic anaemias
+∞
6.3
6
*
57199
ICD-8 Finland
Cirrhosis of liver, Unspecified
+∞
6.3
6
*
M35.1
ICD-10 Finland
Other overlap syndromes
+∞
6.3
6
*
L40.5
ICD-10 Finland
Arthropathic psoriasis
+∞
6.3
6
*
I86.4
ICD-10 Finland
Gastric varices
+∞
6.3
6
*
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
+∞
6.3
6
*
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
+∞
6.3
6
*
L04AC05
ATC
ustekinumab; parenteral
+∞
6.3
6
*
ZXD05
NOMESCO Finland
Urgent procedure
1.5
6.2
227
1651
R53
ICD-10 Finland
Malaise and fatigue
1.5
6.2
199
1408
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.7
6.2
132
847
D70.89
ICD-10 Finland
Neutropenic splenomegaly
5.1
6.2
18
36
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.3
6.2
45
201
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.6
6.2
144
946
RD210, ,
NOMESCO Finland
5.4
6.2
17
32
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.7
6.2
114
705
ZXD10
NOMESCO Finland
Scheduled procedure
1.5
6.1
309
2397
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.6
6.1
180
1250
M79.7
ICD-10 Finland
Fibromyalgia
2.6
6.1
35
140
H26.3
ICD-10 Finland
Drug-induced cataract
12.6
6.1
10
8
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.8
6.1
98
583
J01DB01
ATC
cefalexin; oral
1.5
6.1
680
6110
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
3.2
6.1
23
73
K29.4
ICD-10 Finland
Chronic atrophic gastritis
3.5
6.0
20
58
I35.0
ICD-10 Finland
Aortic (valve) stenosis
2.2
6.0
48
223
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
549
703
19.68
307.65
5.5
2.0
0.20
0.22
g/l
3.46
528
669
494
335
33.10
307.65
2.6
1.8
2.71
1.47
g/l
9.04
463
297
505
422
27.39
307.65
4.0
2.6
12.51
10.58
g/l
9.04
474
377
382
156
43.10
307.65
1.6
1.2
130.00
82.00
titre
0.77
22
20
176
46
47.79
294.01
1.6
1.0
—
—
titre
—
0
0
475
866
10.96
285.26
1.8
1.2
1509.36
368.80
titre
16.06
188
150
207
113
23.78
269.08
1.5
1.2
—
—
—
0
0
146
64
27.25
206.03
1.4
1.0
45.78
52.19
u/l
0.66
135
56
401
850
7.94
200.49
7.4
2.5
8.19
7.30
umol/l
0.44
363
735
694
2534
9.84
198.84
11.4
2.9
39.09
31.42
u/l
3.22
680
2401
786
3364
15.80
188.86
13.4
4.1
35.30
35.90
g/l
3.17
777
3157
144
90
19.00
173.53
1.1
1.1
1.52
1.49
g/l
0.29
130
84
474
1390
6.34
163.64
2.0
1.4
2.56
2.36
g/l
1.40
398
797
141
96
17.36
162.42
1.9
1.9
0.58
0.97
g/l
1.38
117
83
391
981
6.45
159.62
3.1
2.3
23.90
21.94
%
1.65
372
917
397
1074
5.99
147.43
3.1
2.3
2.42
2.35
g/l
1.16
377
995
410
1149
5.89
146.07
3.2
2.3
13.69
12.86
umol/l
1.29
388
1072
95
32
33.23
145.81
1.5
1.1
131.07
73.59
u/l
4.08
87
27
94
31
33.90
145.21
1.5
1.1
29.36
15.00
u/l
1.04
85
25
542
1941
5.81
144.34
12.6
3.7
98.63
92.45
%
6.28
527
1903
725
3402
8.03
138.81
18.6
14.5
1.11
1.23
inr
11.32
651
2763
86
36
26.42
122.26
1.9
1.4
5.17
3.00
u/l
0.78
74
25
90
49
20.39
114.79
1.1
1.1
323.63
300.60
mg/l
1.38
78
43
706
3562
6.37
114.10
5.0
2.3
79.40
79.25
nmol/l
0.05
689
3210
125
128
11.25
111.37
5.3
2.7
33.22
33.24
umol/l
0.00
120
110
63
17
39.89
102.46
3.4
2.2
0.58
0.61
mmol/l
1.19
63
17
146
214
8.01
97.90
2.4
1.2
5.08
8.38
iu/ml
0.47
40
43
71
37
20.82
92.02
1.2
1.0
120.74
101.78
u/l
0.56
66
32
71
38
20.27
90.93
1.2
1.0
28.17
33.60
u/l
0.23
66
33
703
3905
5.29
90.42
11.0
6.1
1.22
1.22
mmol/l
0.23
628
3400
52
11
50.24
89.37
1.8
1.2
9.65
8.39
ug/l
0.43
52
11
650
3496
4.47
84.92
10.2
5.5
1.22
1.22
mmol/l
0.59
626
3219
124
185
7.66
81.39
1.5
1.2
27.34
1.30
u/ml
—
11
5
117
168
7.90
79.38
1.6
1.2
6.95
2.40
u/ml
0.63
32
21
100
122
9.14
77.61
1.5
1.1
25.14
2.12
u/ml
—
14
5
705
4162
4.77
77.35
14.7
8.3
3.77
3.99
e9/l
1.61
653
3554
503
2379
3.67
77.05
4.2
2.3
63.01
63.08
u/l
0.01
473
2185
115
169
7.70
76.37
1.5
1.2
30.59
2.01
u/ml
0.78
26
14
74
60
13.39
76.15
2.3
2.5
32.53
6.25
umol/l
3.98
67
38
102
136
8.37
73.58
2.0
1.2
0.21
0.25
g/l
4.37
97
128
135
246
6.32
73.01
1.5
1.6
0.27
0.38
mg/l
0.74
34
113
399
1683
3.55
72.10
1.5
1.2
0.68
1.37
u/ml
1.28
97
437
88
101
9.59
71.49
7.7
4.8
1077.59
509.30
iu/ml
—
22
10
100
138
8.06
70.00
1.4
1.2
—
—
—
0
0
115
186
6.98
69.79
4.9
2.3
1.71
1.50
mg/l
1.51
110
166
77
76
11.03
69.73
1.4
1.3
360.50
242.10
u/ml
1.22
42
40
759
4989
5.29
65.73
12.5
3.0
122.22
45.76
u/l
23.92
745
4669
295
1085
3.61
64.98
2.7
1.9
30.26
29.11
s
2.99
285
1055
270
939
3.73
64.75
7.4
4.2
1.04
1.04
mmol/l
0.02
260
855
98
147
7.39
63.63
1.5
1.1
59.99
33.11
u/ml
0.76
20
13
45
20
23.68
61.94
3.9
3.1
4.07
6.24
ug/l
1.04
45
20
146
335
5.04
60.91
4.1
3.5
29.94
1061.02
u/ml
1.31
116
293
233
764
3.81
60.57
1.9
1.6
1.48
1.42
%
0.65
187
667
394
1793
3.20
60.46
3.7
2.2
2.98
2.82
mg/l
0.54
364
1536
590
3454
3.23
56.97
4.5
2.9
121.04
106.56
ug/l
0.86
562
3222
233
813
3.55
54.59
3.1
1.3
144.46
95.29
ug/g
2.26
207
609
69
82
9.06
54.34
1.3
1.4
161.57
163.23
au/ml
0.03
12
26
188
586
3.82
51.99
13.3
6.2
10.31
9.33
mmol/l
1.12
182
562
778
5609
4.89
49.89
10.0
3.5
24.94
12.34
mm/h
59.69
762
5209
90
173
5.69
45.46
4.2
3.4
45.09
2199.83
u/ml
0.82
78
159
79
134
6.39
45.38
1.4
1.1
—
—
—
0
0
207
754
3.30
44.42
3.4
4.7
243.24
249.16
u/l
0.15
198
710
63
88
7.64
43.30
1.7
1.4
0.06
0.17
iu/ml
—
10
19
274
1243
2.76
39.11
4.7
3.0
0.80
0.82
mmol/l
3.95
265
1174
104
257
4.46
39.02
1.7
1.5
1.24
1.50
g/l
2.03
88
219
41
41
10.45
36.50
1.0
1.0
—
—
—
0
0
163
576
3.26
36.23
2.8
2.1
70.23
71.28
e9/l
0.12
114
421
42
44
9.98
36.18
1.1
1.1
—
—
—
0
0
167
612
3.14
34.83
2.2
2.1
355.69
400.09
nmol/l
1.80
154
561
217
920
2.81
34.79
4.2
4.3
9.08
22.60
ug/l
0.67
171
745
158
562
3.22
34.65
1.8
2.8
68.17
67.40
g/l
0.45
143
520
137
457
3.37
33.30
1.9
1.5
—
—
—
0
0
98
262
4.09
33.01
2.3
2.2
45.43
40.45
u/l
1.31
92
238
162
610
3.04
32.07
4.1
3.0
83.89
79.67
ng/l
0.25
147
526
185
754
2.85
31.69
4.5
2.2
46.02
37.35
u/l
0.84
172
625
35
35
10.38
31.11
1.1
1.1
—
—
—
0
0
35
35
10.38
31.11
1.1
1.1
—
—
—
0
0
34
35
10.07
29.60
1.1
1.1
—
—
—
0
0
35
38
9.56
29.32
1.1
1.1
—
—
—
0
0
333
1858
2.29
28.85
3.7
2.4
343.09
326.45
umol/l
1.82
303
1633
33
34
10.05
28.70
1.1
1.1
—
—
—
0
0
611
4374
2.36
28.59
9.9
4.3
6.72
6.53
mmol/l
1.22
585
4131
42
62
7.07
27.37
2.6
1.2
—
—
—
0
0
37
55
6.98
23.94
1.3
1.1
65.67
—
u/ml
—
12
0
223
1126
2.32
23.75
1.9
1.7
1043.74
1195.48
nmol/l
1.86
178
818
111
401
3.03
23.29
13.9
8.1
15.12
15.78
%
1.28
103
383
334
2036
2.04
21.67
4.1
2.9
0.26
0.43
e6/l
1.97
261
1409
353
2226
1.99
20.56
2.0
1.6
17.96
20.92
nmol/l
3.97
327
1849
135
578
2.58
20.42
5.4
3.6
1.23
1.23
mmol/l
0.92
130
501
369
2368
1.97
20.39
4.2
3.0
59.93
74.12
e6/l
0.16
297
1732
270
1566
2.05
19.74
3.3
2.4
6.38
7.34
e6/l
0.39
251
1400
85
292
3.12
19.37
1.7
2.0
3.80
3.72
g/l
0.20
74
268
85
292
3.12
19.37
1.7
2.0
7.60
7.38
g/l
0.56
74
268
85
292
3.12
19.37
1.7
2.0
4.42
4.23
g/l
0.81
73
268
535
3960
1.92
18.63
4.7
3.7
0.00
6.40
estimate
1.07
133
768
97
367
2.85
18.62
1.1
1.1
—
—
—
0
0
71
224
3.36
18.60
1.9
3.6
45.36
86.90
mg/l
0.73
62
199
477
3407
1.89
18.48
2.4
2.1
98.99
97.96
pmol/l
0.17
280
1668
71
226
3.33
18.33
1.9
3.6
62.88
67.45
mg/l
0.06
62
200
529
3922
1.90
18.09
4.7
3.7
0.00
0.00
estimate
0.50
125
741
75
250
3.19
17.97
1.8
2.3
0.70
1.41
g/l
0.76
60
222
76
256
3.16
17.89
1.7
2.0
13.33
10.11
g/l
4.24
65
230
536
3999
1.90
17.88
4.8
3.7
0.00
0.43
estimate
0.53
124
733
221
1229
2.07
17.86
2.3
1.8
—
—
—
0
0
77
269
3.04
17.03
1.7
2.1
2.96
2.99
g/l
0.09
66
245
51
137
3.89
16.95
1.8
1.4
—
—
—
0
0
91
353
2.76
16.64
4.3
3.2
0.99
1.87
mmol/l
1.15
69
275
408
2844
1.82
16.40
3.4
3.5
2.36
2.37
mmol/l
0.55
384
2590
62
197
3.31
16.05
1.9
3.3
1.14
4.10
ratio
0.90
42
110
623
4976
1.90
15.73
6.3
4.7
13.67
3227.32
e6/l
—
9
66
145
717
2.23
15.68
14.1
7.1
95.74
95.52
%
0.15
135
695
826
7390
3.68
15.59
34.6
13.5
14.86
24.21
mg/l
29.28
776
5943
65
217
3.16
15.52
1.8
2.0
0.05
0.01
g/l
0.57
53
201
64
215
3.13
15.12
2.9
2.7
—
—
—
0
0
331
2213
1.80
14.89
3.7
3.0
1808.41
1142.03
ng/l
1.38
297
1889
63
212
3.13
14.84
1.3
1.4
294.26
304.98
ug/g
0.13
36
123
64
218
3.09
14.77
1.8
2.1
0.00
0.00
g/l
-0.00
51
195
24
17
14.48
14.60
1.0
1.0
—
—
—
0
0
481
3604
1.75
14.44
3.9
2.6
—
—
estimate
—
0
0
23
36
6.54
14.16
3.4
2.0
487.14
903.52
e6/l
0.59
14
31
138
697
2.17
14.08
14.2
7.3
115.84
119.89
g/l
1.27
130
679
182
1021
1.99
14.01
12.6
6.0
104.38
104.17
mmol/l
0.23
182
1021
24
19
12.96
13.95
1.1
1.1
—
—
—
0
0
344
2364
1.76
13.84
2.4
2.0
127.86
209.49
u/l
1.92
331
2234
169
927
2.02
13.84
2.2
1.7
—
—
—
0
0
207
1225
1.91
13.57
3.4
2.7
4.32
3.29
e6/l
0.40
111
549
72
275
2.77
13.53
2.6
1.2
0.89
0.91
g/l
0.33
72
275
288
1892
1.78
13.46
3.3
2.2
—
—
—
0
0
25
46
5.57
13.12
2.6
2.3
56.00
67.36
%
2.03
20
39
152
818
2.04
13.07
13.8
6.7
-0.10
0.98
mmol/l
2.00
125
693
58
201
3.02
13.00
1.8
2.1
0.00
0.00
g/l
-0.00
51
194
214
1315
1.83
12.33
3.4
2.6
2.69
1.15
e6/l
0.42
121
633
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
53
180
3.07
12.30
2.9
3.8
0.26
0.44
iu/ml
3.15
28
105
130
680
2.07
12.03
5.8
2.8
1.49
1.99
mmol/l
0.70
119
594
56
199
2.94
12.02
1.3
1.2
—
—
—
0
0
149
830
1.96
11.54
14.1
6.7
11.50
12.64
kpa
2.88
142
806
149
830
1.96
11.54
14.2
6.7
4.89
5.14
kpa
3.11
141
804
154
888
1.89
10.72
2.3
1.7
—
—
—
0
0
226
1470
1.73
10.52
4.4
3.5
220.81
282.06
ng/l
0.32
177
1130
61
245
2.60
10.40
2.3
1.8
1.06
1.22
ug/l
0.14
51
215
27
66
4.19
10.21
1.5
1.2
1755.21
2011.51
e6/l
0.15
19
37
48
173
2.88
10.06
1.9
1.7
—
—
—
0
0
21
27
7.94
9.66
1.4
1.5
7.08
12.56
g/l
1.40
13
22
21
44
4.87
9.57
1.7
1.4
—
—
—
0
0
293
2083
1.62
9.54
3.9
3.2
4.66
0.08
estimate
0.79
108
565
93
470
2.10
9.37
2.3
1.7
—
—
—
0
0
52
205
2.63
9.22
1.5
1.2
—
—
—
0
0
23
55
4.27
8.96
1.3
1.3
8167.00
55035.32
e6/l
—
10
22
109
597
1.95
8.79
3.0
2.3
65.37
68.11
ml/min/173m2
0.24
49
250
21
32
6.70
8.69
2.5
2.2
2113.00
50606.23
e6/l
—
10
22
216
1454
1.65
8.63
1.4
1.3
40.21
21.97
iu/ml
0.77
72
422
126
732
1.84
8.48
3.5
3.1
—
—
—
0
0
38
133
2.94
8.42
6.7
5.4
104.97
105.62
mmol/l
0.37
32
116
45
174
2.67
8.30
1.1
1.4
—
—
—
0
0
28
83
3.45
8.13
2.5
2.2
33.50
31.78
pg
1.15
28
83
238
1664
1.59
8.08
2.7
2.9
2.50
2.46
mmol/l
4.45
211
1504
288
2113
1.54
7.88
5.0
3.7
0.00
0.01
estimate
1.34
126
691
380
2961
1.51
7.83
4.6
3.6
1.84
0.05
estimate
0.77
109
582
368
2850
1.51
7.80
4.5
3.5
61.24
42.58
ng/l
0.38
256
1957
672
5920
1.61
7.64
5.3
3.3
15.05
14.58
pmol/l
5.46
632
5394
195
1316
1.62
7.61
1.4
1.3
10.87
3.25
u/ml
0.72
61
486
791
7304
1.98
7.38
30.8
13.8
77.90
79.33
ml/min/173m2
1.05
756
6764
46
192
2.47
7.30
5.1
3.8
2.32
2.43
index
0.05
28
101
42
168
2.58
7.27
3.0
2.0
113.37
127.32
g/l
2.74
30
130
34
122
2.86
7.24
1.4
1.3
—
—
—
0
0
19
48
4.02
6.92
1.3
1.3
0.28
1.23
promille
2.87
19
35
528
4465
1.47
6.84
3.0
2.8
—
—
—
0
0
18
45
4.06
6.65
1.3
1.5
—
—
—
0
0
43
186
2.38
6.34
1.1
1.4
—
—
—
0
0
9
5
18.17
6.27
1.6
1.6
—
—
—
0
0
6
0
+∞
6.26
1.2
0.0
—
—
—
0
0
32
121
2.71
6.21
1.1
1.5
—
—
—
0
0
21
63
3.39
6.03
1.1
1.2
—
—
—
0
0
94
554
1.78
6.01
2.9
3.1
249.99
179.79
ng/l
0.64
85
505
9
6
15.13
5.91
1.8
1.3
—
—
—
0
0
318
2496
1.43
5.84
4.0
3.0
6.23
6.97
mmol/l
2.76
278
2098
49
233
2.17
5.82
1.9
1.9
164.17
329.61
ug/l
1.48
43
221
18
50
3.66
5.78
1.3
1.5
1.68
1.57
nmol/l
0.09
13
44
763
7066
1.68
5.70
6.6
4.4
2.09
1.88
mu/l
2.73
724
6497
53
264
2.07
5.60
2.5
1.9
—
—
—
0
0
61
322
1.96
5.50
5.7
3.7
1.73
1.51
%
0.90
54
301
310
2446
1.42
5.45
4.7
3.7
15.08
6.49
mg/mmol
1.61
200
1426
36
155
2.38
5.40
4.2
2.7
8.79
7.91
kpa
1.92
36
155
77
443
1.81
5.34
1.3
1.2
189.30
80.80
u/ml
1.56
26
144
209
1540
1.47
5.29
1.9
1.6
149143330.57
38073114.78
pmol/l
0.60
175
1266
31
126
2.51
5.26
1.1
1.3
—
—
—
0
0
5
0
+∞
5.21
2.4
0.0
—
—
—
0
0
26
97
2.73
5.21
1.1
1.3
—
—
—
0
0
73
417
1.82
5.19
11.2
5.9
24.34
24.65
mmol/l
0.28
65
396
680
6177
1.47
5.10
42.2
17.5
14.13
13.61
%
15.58
680
6084
30
122
2.51
5.09
3.6
2.4
15.04
15.90
%
0.88
30
122
48
240
2.06
5.04
2.3
1.8
—
—
—
0
0
35
154
2.33
5.02
4.7
2.8
9.24
8.13
pmol/l
0.24
35
154
23
82
2.85
5.01
1.2
1.5
—
—
—
0
0
229
1733
1.44
5.01
2.1
1.8
1.90
1.14
mg/l
2.41
187
1363
15
33
4.61
4.88
2.5
1.6
—
—
—
0
0
12
21
5.78
4.76
1.0
1.6
—
—
—
0
0
23
85
2.75
4.71
1.4
1.3
—
—
—
0
0
23
86
2.72
4.61
1.4
1.3
—
—
—
0
0
8
8
10.08
4.52
1.1
1.0
100.50
114.13
%
—
8
8
13
28
4.70
4.38
1.2
1.1
—
—
—
0
0
13
28
4.70
4.38
1.2
1.1
—
—
—
0
0
33
152
2.22
4.29
1.2
1.3
—
—
—
0
0
33
152
2.22
4.29
4.1
1.6
58.49
58.98
%
0.04
33
152
22
84
2.66
4.26
1.5
1.3
—
—
—
0
0
23
91
2.57
4.16
1.5
1.3
—
—
—
0
0
93
607
1.60
4.09
4.1
2.4
4.31
4.30
kpa
0.01
88
587
32
149
2.19
4.07
1.4
1.3
—
—
—
0
0
32
149
2.19
4.07
1.4
1.3
—
—
—
0
0
399
3402
1.32
3.94
2.4
1.9
1.35
1.34
mmol/l
0.16
347
2895
67
407
1.70
3.90
2.6
3.2
4.41
4.54
pmol/l
0.40
61
369
77
486
1.64
3.89
1.3
1.3
141.66
178.60
u/ml
0.25
67
445
33
159
2.12
3.87
1.6
1.5
—
—
—
0
0
12
28
4.33
3.82
1.2
1.1
—
—
—
0
0
12
28
4.33
3.82
1.2
1.1
—
—
—
0
0
22
90
2.48
3.74
1.5
1.3
—
—
—
0
0
22
90
2.48
3.74
1.5
1.3
—
—
—
0
0
14
39
3.63
3.71
1.0
1.4
—
—
—
0
0
8
12
6.72
3.68
1.0
1.3
—
—
—
0
0
8
12
6.72
3.68
1.1
1.0
1226.38
1188.75
miu/ml
—
8
12
8
12
6.72
3.68
1.3
1.0
—
—
—
0
0
21
85
2.51
3.65
1.2
1.5
—
—
—
0
0
22
92
2.43
3.58
1.5
1.2
3.38
5.57
u/ml
—
8
35
7
9
7.83
3.56
1.0
1.1
—
—
—
0
0
757
7146
1.48
3.54
5.5
4.2
1.24
1.26
mmol/l
0.52
722
6538
85
567
1.55
3.43
2.0
2.4
12.07
5.96
ug/l
0.60
70
499
7
10
7.04
3.37
1.1
1.4
—
—
—
0
0
22
95
2.35
3.36
1.7
1.3
—
—
—
0
0
13
38
3.46
3.32
1.2
1.2
—
—
—
0
0
13
38
3.46
3.32
1.2
1.2
—
—
—
0
0
6
7
8.62
3.26
2.0
1.7
2.24
1.92
ratio
—
6
7
38
207
1.87
3.22
1.2
1.2
201.31
201.39
miu/ml
0.00
16
99
27
130
2.11
3.21
1.1
1.3
—
—
—
0
0
6
8
7.54
3.06
1.0
2.1
—
—
—
0
0
8
16
5.04
3.05
1.8
3.1
4.40
4.84
kpa
—
8
16
8
16
5.04
3.05
1.8
3.1
9.01
9.79
kpa
—
8
16
787
7528
1.51
3.01
6.8
5.1
4.74
4.80
mmol/l
0.98
757
7006
9
21
4.32
3.00
1.0
1.9
—
—
—
0
0
21
94
2.26
2.98
1.6
1.2
2.90
2.92
u/ml
—
10
24
38
213
1.82
2.96
1.3
1.3
—
—
—
0
0
56
352
1.63
2.92
1.7
1.5
—
—
—
0
0
9
22
4.12
2.88
3.6
1.7
0.70
0.69
e9/l
—
9
22
10
27
3.73
2.88
1.0
1.6
—
—
—
0
0
10
27
3.73
2.88
1.0
1.6
—
—
—
0
0
10
27
3.73
2.88
1.0
1.6
—
—
—
0
0
11
33
3.36
2.82
2.5
1.2
4.52
6.44
u/l
0.48
11
27
10
28
3.60
2.79
4.2
4.5
3954.60
1200.21
u/ml
—
10
28
10
28
3.60
2.79
1.5
2.6
1.30
1.73
%
—
10
28
12
39
3.11
2.78
1.3
1.1
—
—
—
0
0
88
623
1.46
2.71
1.5
1.5
—
—
—
0
0
772
7383
1.43
2.69
5.9
5.1
5.94
5.85
mmol/l
1.01
723
6770
17
73
2.36
2.66
6.1
3.6
11.33
11.18
index
0.04
12
44
12
44
2.75
2.55
6.9
3.5
0.92
0.89
index
0.05
12
44
12
42
2.88
2.55
1.1
1.1
—
24.00
—
0
5
5
7
7.18
2.55
4.4
12.1
—
—
—
0
0
5
7
7.18
2.55
1.2
1.0
—
—
—
0
0
10
31
3.25
2.52
1.9
1.1
—
—
—
0
0
158
1253
1.32
2.47
1.5
1.5
—
—
—
0
0
36
578
0.61
2.30
1.7
1.9
3.66
3.56
mmol/l
0.16
24
418
10
35
2.88
2.21
1.0
1.4
—
—
—
0
0
10
35
2.88
2.21
1.0
1.4
—
—
—
0
0
10
35
2.88
2.21
1.0
1.4
—
—
—
0
0
10
35
2.88
2.21
1.0
1.4
—
—
—
0
0
54
778
0.67
2.12
1.8
2.1
3.23
3.37
ratio
0.42
44
625
32
193
1.68
2.02
2.3
1.6
10.16
2.63
iu/l
1.05
12
73
19
97
1.98
2.01
1.1
1.3
0.15
0.37
nmol/l
0.61
11
77
776
7487
1.36
2.00
6.6
5.0
1.59
1.55
mmol/l
1.61
746
6928
34
211
1.64
1.94
1.1
1.1
—
—
—
0
0
34
211
1.64
1.94
1.1
1.1
—
—
—
0
0
6
16
3.77
1.93
1.0
1.1
—
—
—
0
0
206
1745
1.24
1.89
5.2
3.8
1.02
1.91
kg/l
0.50
154
1134
750
7212
1.30
1.89
8.0
6.0
39.26
38.67
mmol/mol
1.05
729
6733
14
65
2.17
1.89
1.1
1.2
101.14
102.78
pmol/l
0.05
14
65
5
12
4.18
1.82
1.2
1.2
—
—
—
0
0
48
329
1.49
1.81
3.9
2.5
25.47
25.69
mmol/l
0.13
42
315
46
313
1.50
1.79
1.5
1.6
8.34
15.20
u/ml
—
5
61
788
7643
1.35
1.75
7.3
5.8
2.67
2.79
mmol/l
3.92
759
7096
6
18
3.35
1.75
1.0
1.8
—
—
—
0
0
57
408
1.43
1.73
3.4
3.5
1.02
1.02
ratio
0.39
50
374
8
30
2.68
1.72
4.1
4.5
—
—
—
0
0
7
24
2.93
1.72
1.1
2.6
38.41
40.24
g/l
—
7
24
25
405
0.61
1.71
1.2
1.1
—
—
—
0
0
12
55
2.20
1.68
1.7
1.2
—
—
—
0
0
23
134
1.74
1.67
2.8
2.3
20.30
85.02
ug/min
1.16
13
69
39
261
1.52
1.66
1.4
1.6
—
—
—
0
0
16
83
1.95
1.65
1.4
1.2
—
—
—
0
0
14
69
2.05
1.65
1.0
1.4
—
—
—
0
0
51
370
1.40
1.47
1.5
1.4
—
—
—
0
0
5
17
2.95
1.36
1.0
1.0
—
—
—
0
0
14
75
1.88
1.35
1.0
1.4
—
—
—
0
0
16
90
1.79
1.33
4.3
4.0
—
—
—
0
0
16
269
0.59
1.31
1.4
1.2
1.65
1.60
g/l
0.52
16
269
25
161
1.57
1.30
2.6
2.0
93.24
4721.21
u/l
—
5
70
25
162
1.56
1.27
1.7
1.6
11327.50
10813.58
e6/l
0.03
14
108
10
49
2.05
1.22
1.0
1.6
—
—
—
0
0
62
481
1.31
1.21
2.6
2.4
34.43
22.01
au/ml
—
7
44
12
64
1.89
1.18
1.0
1.3
—
—
—
0
0
12
64
1.89
1.18
1.0
1.3
—
—
—
0
0
12
64
1.89
1.18
1.0
1.3
—
—
—
0
0
25
166
1.52
1.16
1.4
1.3
—
—
—
0
0
825
8113
1.37
1.15
51.1
21.1
91.59
91.14
fl
1.94
825
8020
116
978
1.21
1.14
5.3
5.1
34.27
32.64
%
0.95
100
619
825
8114
1.37
1.13
52.8
21.5
39.02
39.89
%
6.06
825
8018
825
8114
1.37
1.13
51.2
21.1
4.31
4.44
e12/l
11.46
819
7903
8
40
2.01
1.12
1.1
1.1
—
—
—
0
0
825
8117
1.36
1.10
51.9
21.3
128.68
133.47
g/l
17.29
825
8023
14
81
1.74
1.09
1.1
1.2
—
—
—
0
0
5
21
2.39
1.09
1.2
1.0
—
—
—
0
0
8
41
1.96
1.09
2.3
2.3
—
—
—
0
0
51
648
0.77
1.00
2.9
3.2
0.82
0.75
ug/l
0.22
32
425
74
604
1.25
1.00
2.1
3.7
114.90
85.50
u/ml
0.16
68
587
5
23
2.18
0.98
1.2
1.2
—
—
—
0
0
7
37
1.90
0.94
1.1
1.1
213.43
213.19
mg/l
—
7
32
8
46
1.75
0.82
1.6
1.4
82.88
77.07
umol/l
—
8
46
8
47
1.71
0.81
1.3
1.2
—
—
—
0
0
10
58
1.73
0.80
1.1
1.8
63.30
99.80
ng/l
—
10
58
8
48
1.67
0.79
1.3
1.2
—
—
—
0
0
14
91
1.55
0.75
1.4
1.3
48.91
29.71
u/l
—
9
74
16
109
1.48
0.71
1.8
1.5
—
—
—
0
0
15
102
1.48
0.68
1.0
1.0
0.54
1.43
eliau/ml
—
5
47
6
40
1.50
0.51
2.0
1.3
—
—
—
0
0
43
363
1.19
0.49
1.6
1.4
—
—
—
0
0
13
93
1.40
0.48
1.1
1.1
—
—
—
0
0
11
76
1.45
0.48
2.0
2.1
—
—
—
0
0
12
162
0.74
0.42
1.2
1.6
857.57
805.72
e6/l
—
7
128
5
33
1.52
0.41
1.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
17
0.00
0.40
0.0
1.3
—
—
—
0
0
0
17
0.00
0.40
0.0
1.2
—
—
—
0
0
12
160
0.75
0.40
1.2
1.5
1.40
43.08
e6/l
—
5
121
5
35
1.43
0.39
1.2
1.3
—
—
—
0
0
77
850
0.90
0.38
3.5
4.8
20.95
21.05
%
0.01
31
417
5
36
1.39
0.38
1.2
1.4
—
—
—
0
0
5
77
0.65
0.36
1.2
1.1
—
—
—
0
0
6
43
1.40
0.35
1.2
1.3
—
—
—
0
0
17
203
0.83
0.26
1.4
1.6
436.41
294.11
mu/l
0.65
17
189
15
181
0.83
0.25
1.1
1.3
468.20
524.56
mg/l
0.27
15
170
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
14
166
0.84
0.20
1.1
1.2
3.59
3.64
mmol/l
0.17
14
157
35
317
1.11
0.20
1.8
1.8
—
—
—
0
0
15
174
0.86
0.18
3.9
3.5
36.40
24.43
mg/l
—
10
115
5
69
0.72
0.17
2.0
1.6
—
—
—
0
0
162
1571
1.04
0.15
1.5
1.4
—
—
—
0
0
7
86
0.81
0.14
4.7
2.0
13.66
13.18
%
—
7
86
51
485
1.05
0.11
1.6
1.8
—
—
—
0
0
20
185
1.08
0.08
10.2
3.8
3.98
3.81
mmol/l
0.35
20
185
5
64
0.78
0.08
1.0
1.1
—
—
—
0
0
6
72
0.83
0.07
2.0
1.7
—
—
—
0
0
25
237
1.06
0.05
1.4
1.3
—
—
—
0
0
52
535
0.97
0.05
1.8
1.9
—
—
—
0
0
86
877
0.98
0.04
7.7
6.2
—
—
—
0
0
29
301
0.96
0.04
1.4
1.5
—
—
—
0
0
106
1051
1.01
0.01
4.8
5.7
1.67
2.74
ug/l
1.62
98
937
25
257
0.97
0.01
2.0
1.7
—
—
—
0
0
11
105
1.05
0.00
1.1
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
8.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
1.00
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
0.01
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
0.00
—
0
5
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint CHIRBIL_PRIM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHIRBIL_PRIM | 2.18 [1.95, 2.44] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.801 |
During the follow-up period (1.1.1998 — 31.12.2019), 822 out of 3020 females with CHIRBIL_PRIM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHIRBIL_PRIM | 2.489 [2.04, 3.04] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 293 out of 744 males with CHIRBIL_PRIM died.
Mortality risk
Mortality risk for people of age
years, who have CHIRBIL_PRIM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.199% | 0.429% |
| 5 | 1.305% | 2.574% |
| 10 | 3.684% | 6.805% |
| 15 | 7.08% | 12.789% |
| 20 | 12.048% | 21.548% |
Relationships between endpoints
↥Index endpoint: CHIRBIL_PRIM – Primary biliary cholangitis (PBC)
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data