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Benign neoplasm: other/unspecified salivary gland

DOID Endpoint Browser PheWeb

CD2_BENIGN_SALIVARY_NOS

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D11.7, D11.9&
  • Hospital discharge: ICD-9 — 2102
  • Hospital discharge: ICD-8 — 2102
  • Cause of death: ICD-10 — D11.7, D11.9&
  • Cause of death: ICD-9 — 2102
  • Cause of death: ICD-8 — 2102

2 out of 7 registries used, show all original rules.

1110

4. Check minimum number of events

None

1110

5. Include endpoints

None

1110

6. Filter based on genotype QC (FinnGen only)

1008

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7909 4345 3466
Only index persons 6218 3614 2604
Unadjusted period prevalence (%)
Whole population 0.11 0.12 0.10
Only index persons 0.12 0.13 0.10
Median age at first event (years)
Whole population 53.29 53.09 53.34
Only index persons 49.87 49.80 49.95

-FinnGen-

Key figures

All Female Male
Number of individuals 1008 548 460
Unadjusted period prevalence (%) 0.20 0.19 0.21
Median age at first event (years) 52.51 49.96 55.54

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1027
Matched controls
10270
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
ELB30
NOMESCO Finland
Excision of submandibular gland
218.4
307.7
273
17
D11.70
ICD-10 Finland
Gland sublingual
6219.4
307.7
404
*
2102A
ICD-9 Finland
Benign neoplasm of lip, oral cavity and pharynx, Major salivary glands
+∞
258.6
237
*
21020
ICD-8 Finland
Benign neoplasm of buccal cavity and pharynx, Salivary gland
+∞
247.1
227
*
D11.0
ICD-10 Finland
Benign neoplasm: Parotid gland
24.9
226.5
166
79
4405
FHL
Partial removal of the parotid gland
916.1
163.4
156
*
D11.9
ICD-10 Finland
Benign neoplasm: Major salivary gland, unspecified
+∞
157.4
147
*
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
9.5
125.1
161
198
ELB40
NOMESCO Finland
Partial parotidectomy
18.2
92.7
76
45
EL4AT
NOMESCO Finland
Salivary gland cytology with ultrasound guidance
39.4
91.0
56
15
EP1AE
NOMESCO Finland
Neck ultrasound examination
5.7
81.8
172
353
K11.2
ICD-10 Finland
Sialoadenitis
6.8
50.7
83
132
D11.7
ICD-10 Finland
Benign neoplasm: Other major salivary glands
+∞
46.2
44
*
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
10.9
41.3
45
43
EL3AE
NOMESCO Finland
Salivary gland ultrasound examination
15.5
41.0
36
24
4404
FHL
Complete removal of the parotid gland
+∞
39.8
38
*
D37.00
ICD-10 Finland
Aryepiglottic fold marginal zone
36.8
30.8
39
11
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
7.4
26.0
38
53
PJD91
NOMESCO Finland
Excision of lymph nodes in neck, 1 to 2 areas in total
88.9
23.8
26
*
4403
FHL
Submandibular gland removal
55.4
23.1
27
5
XW1AT
NOMESCO Finland
Biopsy from other organ close to skin with ultrasound quidance
8.9
20.7
26
30
ELB00
NOMESCO Finland
Excision or exploration of lesion of salivary gland
30.8
20.6
27
9
D11.71
ICD-10 Finland
Gland submandibular
+∞
19.9
19
*
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
4.0
18.4
54
142
PJD81
NOMESCO Finland
Excision of lymph nodes from upper part of neck
14.4
16.9
28
20
C08.09
ICD-10 Finland
Malignant tumor of the submandibular or submaxillary gland, other or unspecified histology
61.0
15.8
18
*
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
6.3
15.5
26
42
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
14.4
280
1777
EP1DG
NOMESCO Finland
Very extensive examination of soft tissue of neck with high intesity magnet
11.1
14.0
26
24
WX402
NOMESCO Finland
General anaesthesia
1.8
13.5
229
1389
ELB50
NOMESCO Finland
Total parotidectomy
22.9
12.9
18
8
EP1AE, ,
SPAT
4.5
12.7
31
71
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
15.7
12.6
20
13
K11.9
ICD-10 Finland
Disease of salivary gland, unspecified
12.5
12.6
22
18
4704
FHL
Neck tumor removal
70.8
12.6
14
*
ZXE10
NOMESCO Finland
More than one and less than three hours
1.6
11.1
377
2736
EP2AT
NOMESCO Finland
Neck soft tissue cytology with ultrasound guidance
14.4
10.5
17
12
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
4.3
9.9
25
59
K11.70
ICD-10 Finland
Hypoptyalism
12.3
9.9
17
14
K11.5
ICD-10 Finland
Sialolithiasis
3.9
9.4
27
70
WF003
NOMESCO Finland
Adjuvant radiotherapy
2.8
9.2
44
159
C08.02
ICD-10 Finland
Cystic adenocarcinoma of the submandibular or submaxillary glands
37.0
9.0
11
*
C08.00
ICD-10 Finland
Malignant tumor of submandibular or submaxillary gland, not histology
37.0
9.0
11
*
4701
FHL
Neck lymph node removal
37.0
9.0
11
*
EP1CM
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with 3 Tesla magnet
24.2
8.9
12
5
S04
ICPC
Lump/swelling localized
1.9
8.8
114
630
ZXD10
NOMESCO Finland
Scheduled procedure
1.5
8.5
377
2866
4402
FHL
Removal or exploration of a salivary change (eg ranula)
90.8
8.4
9
*
4409
FHL
Other measure in this category
+∞
8.3
8
*
8200/3-C08.0
ICD-O-3
Adenoid cystic carcinoma of submandibular gland
33.6
8.1
10
*
C07.70
ICD-10 Finland
Malignant tumor of the superficial part of the parotid gland
33.6
8.1
10
*
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
4.5
7.9
19
43
ZXA05
NOMESCO Finland
Left side
1.5
7.7
262
1877
C82.1
ICD-10 Finland
Follicular lymphoma grade II
7.2
7.5
17
24
PJ3AT
NOMESCO Finland
Cytology of lymphnode with ultrasound guidance
4.1
7.4
20
50
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.5
7.3
267
1936
ELB99
NOMESCO Finland
Other excision of salivary gland
+∞
7.3
7
*
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.8
7.2
112
656
C83.80
ICD-10 Finland
B-cell lymphoma in marginal zone
10.1
7.0
13
13
ZXA00
NOMESCO Finland
Right side
1.5
7.0
280
2069
C85.9
ICD-10 Finland
Non-Hodgkin lymphoma, unspecified
5.7
6.8
18
32
EL3AT
NOMESCO Finland
Salivary gland biopsy with ultrasound guidance
22.7
6.7
9
*
QX4AT
NOMESCO Finland
Ultrsound guided needle biopsy of skin
8.8
6.6
13
15
C82.01
ICD-10 Finland
Follicular nodular lymphoma, grade I
10.1
6.5
12
12
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
2.4
6.5
44
190
R22.0
ICD-10 Finland
Localized swelling, mass and lump, head
2.6
6.4
37
148
8430/3-C08.0
ICD-O-3
Mucoepidermoid carcinoma of submandibular gland
+∞
6.3
6
*
C08.90
ICD-10 Finland
Malignant tumor in unspecified large salivary gland without histology
+∞
6.3
6
*
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
5.1
6.2
18
36
UDQ12
NOMESCO Finland
Flexible laryngoscopy
2.0
6.2
61
308
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
3.5
6.0
20
58

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
156
240
7.49
99.62
1.4
1.2
—
—
—
0
0
147
818
1.93
11.23
1.5
1.4
—
—
—
0
0
40
138
2.98
9.05
3.2
1.7
1.24
0.81
g/l
0.87
35
111
431
3484
1.41
6.54
2.3
2.2
—
—
—
0
0
508
4254
1.38
6.12
5.6
5.1
35.42
35.15
g/l
0.49
483
3985
590
5066
1.39
6.08
10.3
9.7
4.30
4.20
e9/l
0.45
519
4403
169
1204
1.48
4.92
1.4
1.3
—
—
—
0
0
23
84
2.78
4.80
1.8
1.3
—
—
—
0
0
243
1860
1.40
4.80
5.3
5.1
—
—
—
0
0
536
4648
1.32
4.61
7.1
6.3
0.20
0.19
e9/l
0.28
460
4039
521
4513
1.31
4.46
7.0
6.1
0.04
0.04
e9/l
0.04
448
3852
485
4170
1.31
4.34
7.5
6.3
9.10
8.99
%
0.32
459
3897
484
4164
1.31
4.30
7.4
6.2
2.99
2.84
%
0.76
460
3887
518
4499
1.31
4.28
7.0
6.1
0.61
0.60
e9/l
0.52
446
3835
482
4160
1.30
4.12
7.5
6.3
0.75
0.68
%
1.87
458
3881
524
4576
1.30
4.08
7.2
6.2
2.13
1.88
e9/l
0.43
462
4007
481
4157
1.30
4.05
7.2
6.2
57.46
57.99
%
0.40
463
3961
175
1305
1.41
3.97
6.6
5.5
1.01
1.03
mmol/l
0.52
166
1203
488
4236
1.29
3.93
7.5
6.3
26.92
26.82
%
0.06
472
4003
15
49
3.09
3.81
1.7
1.6
39.13
38.77
%
0.03
15
49
366
3076
1.29
3.73
3.5
3.6
27.13
89.24
e6/l
1.96
291
2405
320
2647
1.30
3.67
3.3
3.4
0.35
0.47
e6/l
0.68
243
1996
404
3450
1.28
3.61
4.0
4.2
58.72
109.18
e6/l
1.33
299
2494
210
1642
1.35
3.56
3.0
3.1
1.05
1.10
e6/l
0.12
128
902
14
47
3.01
3.42
6.3
6.2
1.37
24.78
ug/l
—
6
30
19
77
2.50
3.31
5.5
4.7
12.10
31.24
u/ml
—
5
25
144
1073
1.40
3.28
2.0
1.8
—
—
—
0
0
358
3040
1.27
3.28
6.4
6.0
—
—
—
0
0
154
1164
1.38
3.23
1.4
1.3
513.51
496.26
titre
0.04
37
278
202
1606
1.32
3.04
3.3
3.2
0.81
0.82
mmol/l
0.66
189
1507
342
2915
1.26
2.99
2.9
2.6
57.48
90.14
u/l
0.62
320
2699
194
1543
1.32
2.91
3.0
2.6
2.26
2.29
g/l
0.29
179
1431
176
1382
1.33
2.88
2.1
2.1
—
—
—
0
0
264
2192
1.28
2.85
2.8
2.7
6.68
5.45
e6/l
0.71
231
2015
38
216
1.79
2.83
4.3
2.8
89.13
89.45
%
0.09
38
209
543
4892
1.23
2.82
7.0
6.6
11.89
11.68
umol/l
0.10
519
4673
205
1650
1.30
2.81
1.4
1.5
2.33
2.58
g/l
1.25
125
964
114
842
1.40
2.75
2.3
2.6
5.55
7.02
ug/l
0.65
102
744
109
800
1.41
2.73
1.6
1.5
—
—
—
0
0
20
92
2.20
2.68
1.5
1.1
—
—
—
0
0
204
1657
1.29
2.61
3.1
2.6
11.83
12.52
umol/l
0.68
187
1552
35
200
1.78
2.59
1.2
1.2
70.18
57.77
u/ml
—
5
25
188
1515
1.29
2.55
3.0
3.3
2.35
2.31
e6/l
0.02
104
771
69
471
1.50
2.54
2.4
2.4
—
—
—
0
0
534
4837
1.22
2.52
8.8
7.4
1.21
1.21
mmol/l
0.03
467
4176
488
4385
1.22
2.48
7.2
6.7
1.21
1.21
mmol/l
0.04
450
4041
384
3372
1.22
2.46
3.8
3.6
2.34
2.36
mmol/l
1.33
353
3041
468
4200
1.21
2.38
3.0
2.8
—
—
estimate
—
0
0
224
1870
1.25
2.28
5.0
4.1
211.32
359.03
ng/l
0.90
191
1546
15
66
2.29
2.25
2.4
3.0
7.91
8.22
mmol/l
0.14
15
66
0
60
0.00
2.25
0.0
1.1
—
292.96
—
0
53
176
1432
1.28
2.22
3.2
2.6
19.64
22.14
%
1.95
163
1341
430
3850
1.20
2.19
13.4
12.0
0.00
0.00
e9/l
0.26
344
3149
638
5933
1.20
2.11
5.4
5.1
974.23
2204.50
e6/l
0.65
13
98
661
6168
1.20
2.10
4.8
4.4
—
5942.47
—
0
17
724
6816
1.21
2.09
9.4
8.5
82.69
80.82
u/l
0.36
688
6452
94
707
1.36
2.08
3.1
3.1
10.12
10.76
g/l
0.76
87
655
224
1894
1.23
2.02
1.3
1.3
0.91
1.35
u/ml
0.92
51
500
11
44
2.52
2.01
1.6
1.3
—
—
—
0
0
127
1008
1.30
1.95
2.0
2.2
135.35
130.87
ug/g
0.04
98
811
336
2968
1.20
1.94
2.5
2.2
178.04
230.47
u/l
0.87
317
2819
125
992
1.30
1.93
4.4
3.4
2.16
1.90
mmol/l
0.35
112
841
101
783
1.32
1.85
4.5
3.7
96.20
91.34
ng/l
0.21
83
685
129
1034
1.28
1.85
4.6
3.4
7.38
7.38
ph
0.09
87
607
241
2074
1.21
1.83
5.2
4.4
1.02
1.02
kg/l
0.09
153
1405
133
1072
1.28
1.83
1.7
1.7
—
—
—
0
0
19
101
1.90
1.81
1.1
1.5
72.02
63.38
%
—
9
66
15
73
2.07
1.81
1.1
1.4
31.59
30.52
%
—
8
46
139
1128
1.27
1.81
1.7
1.4
—
—
—
0
0
336
2985
1.19
1.80
2.6
2.5
—
—
—
0
0
39
257
1.54
1.76
4.5
2.7
7.88
8.03
kpa
0.24
39
252
36
233
1.56
1.75
1.6
1.3
—
—
—
0
0
110
871
1.29
1.74
9.7
6.9
10.23
10.59
mmol/l
0.21
104
835
39
258
1.53
1.73
5.1
3.0
1.74
1.58
mmol/l
0.23
39
253
441
4019
1.17
1.72
3.6
3.0
134.52
135.02
ug/l
0.02
404
3707
582
5422
1.17
1.72
5.5
5.2
7.02
6.73
mmol/l
2.41
557
5170
33
212
1.58
1.67
5.6
3.2
7.33
7.63
mmol/l
0.26
33
207
15
76
1.99
1.65
2.1
2.1
1.86
1.92
u/field
—
7
37
217
1869
1.20
1.63
3.2
3.0
518.17
529.99
mosm/kgh2o
0.36
187
1654
19
106
1.81
1.59
1.3
1.2
—
—
nmol/l
—
0
0
258
2265
1.19
1.57
2.3
2.4
—
—
—
0
0
101
803
1.29
1.57
3.0
2.6
0.26
0.58
e6/l
1.50
96
764
53
383
1.40
1.54
1.5
2.5
8.64
10.54
g/l
3.32
48
340
312
2787
1.17
1.54
5.1
4.4
—
—
—
0
0
511
4739
1.16
1.53
4.8
4.2
0.01
0.33
estimate
0.51
98
962
130
1069
1.25
1.53
3.2
4.2
10.52
25.86
ug/l
0.99
110
891
33
217
1.54
1.53
2.9
2.5
90.47
86.34
ug/min
0.04
22
125
24
146
1.66
1.51
1.2
1.4
—
—
—
0
0
145
1209
1.23
1.51
2.7
2.5
1.90
1.81
%
0.49
127
1086
42
293
1.45
1.48
1.7
1.6
12.76
12.50
u/ml
—
7
55
501
4648
1.15
1.48
4.7
4.2
0.00
0.00
estimate
-0.00
101
995
9
38
2.38
1.46
1.0
1.2
—
2.00
%
—
0
7
18
102
1.78
1.45
1.2
1.3
—
—
—
0
0
6
22
2.74
1.43
2.2
1.4
41.17
28.91
%
—
6
22
60
449
1.36
1.43
2.4
1.8
4.00
2.06
ug/l
0.34
55
404
50
363
1.40
1.43
2.6
4.0
33.17
54.62
mg/l
1.14
44
314
323
2908
1.16
1.43
3.6
3.2
35.19
32.62
u/l
0.30
306
2744
305
2734
1.16
1.43
6.8
6.3
—
—
—
0
0
9
39
2.32
1.43
3.0
3.3
1249.78
1267.33
u/ml
—
9
39
50
364
1.39
1.41
2.6
4.0
78.89
68.25
mg/l
0.12
44
313
505
4699
1.15
1.41
4.8
4.2
0.00
3.44
estimate
0.80
104
1018
325
2934
1.16
1.38
4.9
4.3
7.40
7.40
ph
0.33
250
2140
142
1194
1.22
1.37
6.6
7.8
7.42
7.42
ph
0.53
85
692
38
265
1.45
1.36
2.5
2.8
1.63
1.68
mg/l
0.13
33
235
152
1289
1.21
1.35
1.3
1.2
—
—
—
0
0
109
893
1.25
1.35
1.9
3.0
65.84
66.54
g/l
0.46
103
823
71
551
1.31
1.34
2.8
2.6
32.35
22.20
au/ml
—
6
41
16
90
1.79
1.33
1.5
1.2
—
—
—
0
0
98
795
1.26
1.32
2.8
3.2
284.31
230.08
ng/l
0.39
85
734
20
121
1.67
1.31
1.4
1.2
0.71
15.68
nmol/l
0.49
20
113
440
4072
1.14
1.30
2.6
2.5
77.34
78.78
nmol/l
0.50
394
3643
45
327
1.39
1.30
2.8
3.8
3.68
3.82
ratio
0.02
31
194
46
336
1.39
1.29
1.3
1.2
—
—
—
0
0
24
154
1.57
1.26
1.3
1.2
7.85
10.21
u/l
0.52
17
120
704
6728
1.15
1.26
26.5
22.4
13.83
13.79
%
0.32
699
6638
91
740
1.25
1.22
1.6
2.7
—
—
—
0
0
5
19
2.64
1.21
5.0
6.0
11.40
8.05
mmol/l
—
5
19
60
463
1.31
1.20
4.5
3.9
—
—
—
0
0
268
2409
1.15
1.20
3.5
3.3
0.00
0.03
—
9
66
9
167
0.53
1.19
1.0
1.1
—
—
—
0
0
6
26
2.32
1.19
1.0
1.2
209.00
190.95
iu/ml
—
6
26
61
474
1.31
1.17
1.6
1.8
1.81
1.55
g/l
1.13
56
425
103
854
1.23
1.16
5.9
8.2
—
—
—
0
0
139
1189
1.20
1.15
6.9
7.7
1.51
1.08
mmol/l
0.56
113
984
23
150
1.55
1.15
1.8
2.3
1.23
0.87
%
2.29
17
109
33
233
1.43
1.14
5.0
5.0
—
—
—
0
0
481
4505
1.13
1.14
20.2
16.6
1.37
1.29
inr
0.65
394
3750
81
656
1.25
1.13
9.5
7.5
24.62
24.56
mmol/l
0.04
75
631
229
2044
1.15
1.13
3.5
3.1
2.46
2.46
mmol/l
0.21
209
1849
140
1201
1.19
1.12
6.8
7.7
4.97
5.11
kpa
0.96
132
1158
140
1202
1.19
1.12
6.8
7.7
11.80
11.94
kpa
0.10
133
1160
5
21
2.39
1.09
1.2
1.2
—
—
—
0
0
351
3232
1.13
1.09
4.3
4.1
12.48
9.06
mg/mmol
0.54
212
2024
329
3020
1.13
1.07
3.8
3.4
—
—
—
0
0
80
652
1.25
1.07
4.4
3.7
7.42
7.42
ph
0.07
71
553
25
170
1.48
1.05
1.3
1.6
—
—
—
0
0
265
2402
1.14
1.05
3.0
2.8
343.61
348.54
umol/l
0.33
233
2083
5
22
2.28
1.03
1.0
1.3
—
—
—
0
0
7
34
2.07
1.03
1.9
1.4
1.73
1.93
umol/l
—
7
29
350
3238
1.12
0.99
3.6
3.4
6.85
7.25
mmol/l
1.01
290
2729
683
6562
1.12
0.99
5.0
4.4
15.09
14.93
pmol/l
0.85
618
5972
61
487
1.27
0.98
4.3
4.5
36.79
36.90
°c
0.51
61
482
11
61
1.81
0.98
1.5
1.5
1.00
1.09
promille
—
6
50
21
140
1.51
0.98
7.7
6.0
11.82
12.38
mg/l
0.31
21
132
20
132
1.53
0.97
1.8
2.2
33.05
32.41
pg
0.38
20
132
7
36
1.95
0.97
1.6
1.8
—
—
—
0
0
18
117
1.55
0.94
1.3
1.3
—
—
—
0
0
6
27
2.23
0.93
1.0
1.7
18.67
16.23
pmol/l
—
6
20
375
3495
1.11
0.93
5.1
4.2
0.00
0.03
estimate
3.03
81
819
24
337
0.71
0.91
3.5
3.3
482.58
294.59
mg/l
0.45
12
136
27
193
1.41
0.91
1.4
1.2
28.14
40.41
e6/l
0.13
21
145
24
168
1.44
0.90
1.4
1.2
—
—
—
0
0
123
1067
1.17
0.90
6.8
8.1
94.31
95.37
%
0.63
115
1036
35
263
1.34
0.89
1.3
1.6
0.25
0.24
g/l
0.20
35
253
36
273
1.33
0.86
1.3
1.5
1.23
1.19
g/l
0.44
36
263
114
988
1.17
0.85
6.9
8.5
120.18
120.17
g/l
0.00
109
968
16
104
1.55
0.85
1.4
1.3
—
—
—
0
0
46
363
1.28
0.84
1.4
2.0
13.30
8.00
iu/ml
—
7
83
53
426
1.26
0.84
1.2
1.2
—
—
—
0
0
17
113
1.51
0.82
1.8
2.3
1.76
1.23
g/24h
—
7
65
339
3163
1.11
0.81
3.6
3.4
76.97
48.90
mg/l
0.88
214
2035
13
81
1.61
0.81
1.5
1.2
—
—
—
0
0
32
242
1.33
0.79
1.4
1.7
—
—
—
0
0
9
148
0.60
0.79
1.2
1.1
—
—
—
0
0
6
33
1.82
0.79
1.0
1.2
—
—
—
0
0
396
3732
1.10
0.77
4.4
3.7
6.29
6.24
ph
0.35
218
2082
15
99
1.52
0.76
1.3
1.4
18.00
25.05
ng/l
0.89
15
99
99
858
1.17
0.75
2.3
2.1
363.33
381.50
nmol/l
0.37
89
796
275
2551
1.11
0.74
2.7
2.3
3.06
2.94
mg/l
0.33
244
2179
14
92
1.53
0.72
1.2
1.1
—
—
—
0
0
21
151
1.40
0.71
2.1
1.8
1.74
1.63
mmol/l
0.22
21
146
16
109
1.48
0.71
1.2
1.1
—
—
—
0
0
16
109
1.48
0.71
1.2
1.1
—
—
—
0
0
25
186
1.35
0.70
4.1
4.5
3.85
2.76
mmol/l
0.51
14
132
26
195
1.34
0.70
1.4
1.3
1599.86
724.81
e6/l
0.30
21
150
9
144
0.62
0.70
1.1
1.0
—
—
—
0
0
793
7747
1.10
0.66
6.1
5.5
1.90
1.98
mu/l
1.05
732
7085
37
295
1.26
0.66
1.5
1.4
256.78
287.58
ug/g
0.45
24
184
17
120
1.42
0.65
1.4
1.4
—
—
—
0
0
99
871
1.15
0.64
2.1
2.5
33.04
36.61
u/l
0.46
84
729
390
3700
1.09
0.64
4.9
4.2
38.27
63.89
ng/l
0.83
291
2811
14
95
1.48
0.64
1.1
1.1
2.20
1.59
eliau/ml
—
5
31
175
1600
1.11
0.62
1.4
1.3
28.15
32.00
iu/ml
0.29
64
494
26
200
1.31
0.61
1.2
1.2
—
—
—
0
0
13
88
1.48
0.60
1.6
1.1
—
—
—
0
0
0
20
0.00
0.60
0.0
2.9
—
3791.50
—
0
20
15
105
1.43
0.60
2.7
2.1
-0.49
0.81
mmol/l
0.55
15
100
32
254
1.27
0.60
3.6
3.3
0.55
2.01
index
1.72
11
135
16
115
1.40
0.56
2.1
1.8
87.88
89.75
%
0.46
16
115
91
805
1.14
0.56
1.8
1.5
—
—
—
0
0
446
4273
1.08
0.56
2.4
2.3
95.32
95.37
pmol/l
0.01
255
2214
43
357
1.21
0.56
1.1
1.1
—
—
—
0
0
55
468
1.19
0.55
4.5
3.9
1.02
1.02
ratio
0.80
50
441
342
3599
0.93
0.55
1.8
2.0
1.37
1.34
mmol/l
0.27
278
2979
82
721
1.15
0.55
2.9
2.8
6.25
6.07
ph
1.05
62
508
12
82
1.47
0.54
1.7
1.2
—
—
—
0
0
26
327
0.79
0.53
1.5
1.5
0.46
0.31
mg/l
—
7
143
13
91
1.43
0.53
1.9
1.5
—
—
—
0
0
31
251
1.24
0.51
1.8
1.6
8632.88
14704.62
e6/l
0.81
26
175
840
8260
1.09
0.51
22.0
17.9
27.32
25.56
mg/l
0.71
733
6950
24
189
1.28
0.50
5.0
3.2
57.26
59.31
%
0.44
24
189
26
207
1.26
0.49
3.7
3.8
—
—
—
0
0
11
76
1.45
0.48
1.9
2.1
—
—
—
0
0
7
49
1.43
0.46
1.3
1.2
110.86
143.52
nmol/l
—
7
49
19
147
1.30
0.45
4.9
3.3
4.01
4.43
e9/l
0.34
19
147
12
86
1.40
0.44
1.2
1.0
0.19
2.76
u/ml
—
6
31
103
937
1.11
0.43
2.6
2.6
73.25
68.72
e9/l
0.82
82
707
52
453
1.16
0.42
1.9
2.1
—
—
—
0
0
8
56
1.43
0.42
1.6
1.8
—
—
—
0
0
96
872
1.11
0.42
1.8
1.6
—
—
—
0
0
60
529
1.14
0.42
1.3
1.4
—
—
—
0
0
22
176
1.26
0.42
1.8
1.5
—
—
—
0
0
30
249
1.21
0.42
2.8
3.4
0.77
0.82
nmol/l
0.25
21
211
822
8095
1.08
0.42
6.0
5.5
6.14
6.02
mmol/l
1.61
743
7378
39
455
0.85
0.41
2.3
2.1
0.00
0.01
estimate
0.50
11
133
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
0.54
—
0
8
19
150
1.27
0.40
3.6
2.5
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
5
35
1.43
0.39
1.2
1.4
165.20
167.45
mmol/24h
—
5
35
0
19
0.00
0.39
0.0
2.3
—
2.96
—
0
7
867
8562
1.08
0.39
25.1
21.6
139.66
139.66
mmol/l
0.00
853
8386
12
89
1.35
0.38
1.2
1.0
0.46
3.46
u/ml
—
5
39
12
89
1.35
0.38
1.0
1.1
—
—
—
0
0
280
2676
1.06
0.37
5.1
4.3
0.00
0.00
estimate
0.75
84
916
305
2923
1.06
0.37
3.7
3.4
—
—
—
0
0
303
2904
1.06
0.37
1.8
1.8
20.87
20.42
nmol/l
0.18
261
2435
181
1706
1.07
0.36
3.1
3.4
0.78
0.81
ug/l
0.09
121
1163
9
70
1.29
0.36
1.1
1.2
—
—
—
0
0
105
968
1.09
0.36
1.9
1.6
—
—
—
0
0
5
79
0.63
0.35
1.2
1.2
—
—
—
0
0
18
144
1.25
0.35
2.3
2.6
—
—
—
0
0
15
117
1.29
0.35
1.3
1.4
272900.00
91208.33
e6/l
—
9
61
257
2456
1.06
0.35
4.3
3.7
0.00
0.04
estimate
0.69
77
791
6
45
1.34
0.33
1.2
1.4
41.00
25.06
umol/l
—
6
39
27
228
1.19
0.33
1.1
1.2
527.11
511.25
mg/l
0.06
27
217
14
109
1.29
0.33
1.6
1.9
24291.52
3443.65
u/l
—
5
42
33
284
1.17
0.33
9.5
7.7
1.63
1.37
mmol/l
0.47
28
253
867
8574
1.07
0.33
25.7
21.8
3.98
3.99
mmol/l
0.54
852
8385
6
47
1.28
0.32
1.2
1.2
154.83
482.52
u/l
—
6
42
11
83
1.33
0.32
1.6
2.7
—
—
—
0
0
12
92
1.31
0.32
1.2
1.2
2.00
1.49
nmol/l
0.64
12
81
13
101
1.29
0.31
2.5
2.5
—
—
—
0
0
10
75
1.34
0.30
1.1
1.1
92.30
102.63
pmol/l
—
10
75
103
1105
0.92
0.30
3.4
3.3
4.45
5.35
e9/l
0.66
82
954
49
440
1.12
0.29
1.4
1.3
—
—
—
0
0
72
661
1.10
0.29
5.9
9.3
92.70
93.83
%
0.42
72
656
805
7954
1.06
0.28
8.1
7.0
40.20
39.84
mmol/mol
0.55
743
7394
86
797
1.09
0.28
5.4
4.4
1.13
0.58
%
1.53
30
255
38
428
0.88
0.28
1.6
1.6
—
—
—
0
0
23
196
1.18
0.27
1.2
1.2
—
—
—
0
0
97
906
1.08
0.27
6.3
4.5
7.37
7.35
ph
1.35
69
651
100
1068
0.93
0.27
2.9
2.8
11.30
7.88
umol/l
0.33
87
947
53
481
1.11
0.27
2.1
1.8
3.64
3.48
mmol/l
0.47
36
361
13
104
1.25
0.26
1.1
1.9
—
—
—
0
0
9
75
1.20
0.25
2.2
2.4
—
49.64
—
0
10
29
255
1.14
0.24
1.2
1.2
—
—
—
0
0
56
514
1.09
0.24
1.3
1.2
72.79
118.27
u/ml
1.13
17
199
35
313
1.12
0.23
1.6
1.7
—
—
—
0
0
15
125
1.20
0.22
1.6
1.6
—
—
—
0
0
324
3154
1.04
0.22
4.0
3.2
1740.02
1524.61
ng/l
0.35
278
2738
89
837
1.07
0.22
5.4
4.4
1.38
0.98
%
0.53
28
276
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
66.00
—
0
11
0
10
0.00
0.21
0.0
1.0
—
6.55
—
0
10
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
1.49
—
0
5
0
10
0.00
0.21
0.0
1.1
—
7.46
—
0
5
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
1.69
—
0
12
0
13
0.00
0.21
0.0
12.8
—
5.41
—
0
13
0
14
0.00
0.20
0.0
1.1
—
0.02
—
0
14
6
48
1.25
0.20
2.0
1.3
33.50
31.07
umol/l
—
6
43
70
655
1.07
0.20
1.2
1.2
—
—
—
0
0
11
133
0.83
0.19
2.7
1.3
—
—
—
0
0
14
118
1.19
0.19
1.1
1.1
—
—
—
0
0
6
52
1.15
0.19
3.3
2.5
519.83
494.65
min
—
6
34
224
2303
0.97
0.17
1.5
1.4
—
—
—
0
0
295
2883
1.03
0.16
5.8
5.8
2.54
3.31
ug/l
0.67
262
2567
85
808
1.06
0.16
6.0
4.8
0.22
0.12
%
0.31
27
221
552
5447
1.03
0.16
3.6
3.3
59.36
52.76
u/l
0.51
516
5075
155
1499
1.04
0.15
1.4
1.3
3.76
11.80
u/ml
3.49
59
549
182
1767
1.04
0.15
1.8
1.8
1182.06
1174.99
nmol/l
0.03
143
1338
25
226
1.11
0.15
1.2
1.8
2.34
4.10
iu/l
—
9
83
83
791
1.05
0.15
5.6
4.6
0.17
0.11
%
0.20
23
231
835
8297
1.03
0.14
6.6
6.2
2.59
2.64
mmol/l
0.68
770
7629
196
2012
0.97
0.14
1.7
1.8
455.66
20964298.57
pmol/l
1.46
167
1660
22
242
0.91
0.13
1.2
1.1
—
—
—
0
0
9
108
0.83
0.13
2.7
1.3
—
—
—
0
0
61
580
1.05
0.12
3.6
3.4
24.90
24.22
mmol/l
0.81
61
574
26
239
1.09
0.12
1.2
1.1
—
—
—
0
0
87
904
0.96
0.12
2.3
2.1
0.00
0.03
estimate
0.78
18
170
25
271
0.92
0.11
9.9
11.8
—
—
—
0
0
13
115
1.13
0.10
1.2
1.4
—
—
—
0
0
13
146
0.89
0.10
2.5
1.3
—
—
—
0
0
13
146
0.89
0.10
2.5
1.3
—
—
—
0
0
57
545
1.05
0.10
1.4
1.4
—
—
—
0
0
868
8645
1.03
0.09
14.7
12.9
25.31
25.00
u/l
0.21
843
8380
6
55
1.09
0.09
1.0
1.1
—
—
—
0
0
27
253
1.07
0.08
1.1
1.2
—
1223.33
—
0
9
82
795
1.03
0.08
5.4
3.8
1.21
1.23
mmol/l
0.97
76
685
13
144
0.90
0.08
2.5
1.3
—
—
—
0
0
5
61
0.82
0.08
1.8
1.6
—
—
—
0
0
5
61
0.82
0.08
1.8
1.8
—
—
—
0
0
20
185
1.08
0.08
1.2
1.2
1.57
1.58
g/l
0.02
20
185
13
117
1.11
0.08
1.2
1.2
—
—
—
0
0
7
65
1.08
0.08
2.1
3.1
13.61
16.34
%
—
7
65
73
707
1.04
0.08
4.7
4.0
—
—
—
0
0
6
71
0.84
0.07
3.5
1.3
—
—
—
0
0
6
75
0.80
0.07
1.0
1.1
—
—
—
0
0
13
143
0.91
0.07
2.5
1.3
—
—
—
0
0
8
94
0.85
0.06
1.5
1.2
—
—
—
0
0
9
103
0.87
0.06
2.0
2.5
—
—
—
0
0
812
8094
1.02
0.05
5.6
5.3
1.44
1.48
mmol/l
1.64
741
7427
13
141
0.92
0.05
1.8
1.7
—
—
—
0
0
876
8742
1.01
0.04
28.3
23.8
82.67
80.01
umol/l
1.01
866
8630
816
8141
1.01
0.04
5.7
5.4
4.51
4.58
mmol/l
1.02
750
7522
16
151
1.06
0.03
5.1
3.7
1.31
1.57
%
0.19
16
139
51
499
1.02
0.03
1.6
1.4
—
—
—
0
0
885
8863
0.99
0.02
32.9
27.1
91.40
91.55
fl
0.47
875
8747
199
2004
0.99
0.02
1.7
1.6
1.31
1.34
mg/l
0.06
155
1584
842
8407
1.01
0.02
19.6
16.1
—
—
—
0
0
58
590
0.98
0.02
1.2
1.3
—
—
—
0
0
776
7772
0.99
0.02
4.9
4.5
1.34
1.28
mmol/l
1.29
698
7075
13
123
1.06
0.01
1.4
1.5
—
—
—
0
0
13
123
1.06
0.01
1.4
1.5
—
—
—
0
0
13
123
1.06
0.01
1.4
1.5
—
—
—
0
0
13
123
1.06
0.01
1.4
1.5
—
—
—
0
0
328
3288
1.00
0.01
4.3
3.8
—
0.77
—
0
13
886
8867
0.99
0.00
33.3
27.4
132.55
133.23
g/l
0.66
878
8748
18
186
0.97
0.00
1.3
1.2
—
—
—
0
0
40
406
0.98
0.00
3.0
2.8
—
—
—
0
0
11
112
0.98
0.00
1.2
1.1
1.65
1.51
g/l
0.69
11
104
12
122
0.98
0.00
1.4
1.2
53.75
101.03
mu/l
0.46
12
110
886
8864
1.00
0.00
32.8
27.1
30.33
30.40
pg
0.53
876
8745
886
8864
1.00
0.00
33.0
27.2
4.40
4.42
e12/l
0.47
862
8639
886
8864
1.00
0.00
33.2
27.7
39.73
39.83
%
0.21
877
8740
886
8864
1.00
0.00
33.0
27.2
7.05
6.79
e9/l
0.90
865
8638
17
169
1.01
0.00
1.2
1.1
0.60
0.71
ratio
—
6
29
103
1027
1.00
0.00
1.3
1.3
—
—
—
0
0
7
79
0.89
0.00
1.7
1.2
—
—
—
0
0
6
63
0.95
0.00
2.8
1.7
139.83
104.42
ng/l
—
6
63
0
5
0.00
-0.00
0.0
6.2
—
—
—
0
0
8
88
0.91
-0.00
1.4
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.06
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
77.94
—
0
5
0
8
0.00
-0.00
0.0
1.0
—
64.00
—
0
8
0
5
0.00
-0.00
0.0
1.2
—
30.86
—
0
5
5
59
0.85
-0.00
3.4
2.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
366.67
—
0
6
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
0.02
—
0
6
0
8
0.00
-0.00
0.0
5.6
—
0.33
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
8.3
—
0.13
—
0
6
6
69
0.87
-0.00
1.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
73
0.96
-0.00
2.6
1.9
—
—
—
0
0
7
74
0.95
-0.00
1.3
1.2
—
—
—
0
0
5
59
0.85
-0.00
1.0
1.2
7.46
7.35
ph
—
5
39
0
5
0.00
-0.00
0.0
1.0
—
0.03
—
0
5
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
57
0.88
-0.00
3.2
1.4
95.20
84.16
umol/l
—
5
57
886
8860
1.00
-0.00
33.0
27.2
248.26
247.21
e9/l
0.18
871
8665
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
9
98
0.92
-0.00
4.7
3.7
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_SALIVARY_NOS and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_SALIVARY_NOS 1.304 [1.12, 1.52] < 0.001
Birth year 0.995 [0.99, 1.0] 0.225

During the follow-up period (1.1.1998 — 31.12.2019), 403 out of 1694 females with CD2_BENIGN_SALIVARY_NOS died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_SALIVARY_NOS 1.63 [1.38, 1.93] < 0.001
Birth year 0.988 [0.98, 1.0] 0.011

During the follow-up period (1.1.1998 — 31.12.2019), 407 out of 1374 males with CD2_BENIGN_SALIVARY_NOS died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_SALIVARY_NOS.

N-year risk Females Males
1 0.084% 0.371%
5 0.664% 1.865%
10 1.9% 4.564%
15 3.672% 8.531%
20 6.75% 14.404%

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_SALIVARY_NOS – Benign neoplasm: other/unspecified salivary gland

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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