Benign neoplasm: Pelvic bones, sacrum and coccyx

CD2_BENIGN_PELVIC_BONES_SACRUM_COCCYX

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D16.8&
  • Hospital discharge: ICD-9 2136
  • Hospital discharge: ICD-8 21305
  • Cause of death: ICD-10 D16.8&
  • Cause of death: ICD-9 2136
  • Cause of death: ICD-8 21305

2 out of 7 registries used, show all original rules.

177

4. Check minimum number of events

None

177

5. Include endpoints

None

177

6. Filter based on genotype QC (FinnGen only)

160

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D16
Name in latin
Neoplasma benignum ossis coxae, ossis sacri sive ossis coccygis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 995 538 448
Only index persons 868 483 385
Unadjusted period prevalence (%)
Whole population 0.01 0.02 0.01
Only index persons 0.02 0.02 0.01
Median age at first event (years)
Whole population 40.90 43.81 37.09
Only index persons 39.57 42.49 35.90

-FinnGen-

Key figures

All Female Male
Number of individuals 160 100 60
Unadjusted period prevalence (%) 0.03 0.04 0.03
Median age at first event (years) 46.51 44.72 49.48

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
165
Matched controls
1650
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D16.8
ICD-10 Finland
Benign neoplasm: Pelvic bones, sacrum and coccyx
+∞
171.0
133
*
D48.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage
70.7
30.5
34
6
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
58.1
25.2
29
6
NER20
NOMESCO Finland
Incomplete excision of soft tissue tumour of pelvis
+∞
20.2
19
*
21305
ICD-8 Finland
Benign neoplasm of bone and cartilage, Pelvis, sacri, coccygis
+∞
20.2
19
*
NK6CT
NOMESCO Finland
Bone biopsy with CT guidance
71.0
17.1
19
*
NE1AA
NOMESCO Finland
Pelvis X-ray examination
5.8
16.8
35
73
NE1AD
NOMESCO Finland
Pelvis and hip bones CT examination
20.3
15.7
23
13
2136A
ICD-9 Finland
Benign neoplasm of bone and articular cartilage, Pelvic bones, sacrum and coccyx
+∞
14.8
14
*
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
11.0
12.7
24
25
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
9.7
10.1
20
23
D16.2
ICD-10 Finland
Benign neoplasm: Long bones of lower limb
39.0
9.1
11
*
NEA20
NOMESCO Finland
Exploration of soft tissue of pelvis,v
+∞
8.4
8
*
NE1DG
NOMESCO Finland
Pelvic, hip and femur very extensive MRI examination with high intensity magnet
23.4
8.1
11
5
9102
FHL
Trepanation or removal of the local bone process
47.3
7.8
9
*
NK6BN
NOMESCO Finland
Bone dynamic isotope examination
47.3
7.8
9
*
NER50
NOMESCO Finland
Other operation for tumour of pelvis
+∞
7.3
7
*
9101
FHL
Bone biopsy
+∞
7.3
7
*
D16.90
ICD-10 Finland
Bone and articular cartilage, unspecified
+∞
6.3
6
*
M16.1
ICD-10 Finland
Other primary coxarthrosis
3.1
6.3
28
101
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.3
6.1
73
427
B01AB05
ATC
enoxaparin; parenteral
2.3
6.1
60
324

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
117
853
2.28
5.45
8.4
10.1
3.88
4.10
e9/l
0.68
106
732
108
770
2.17
5.21
4.8
3.8
0.00
0.00
estimate
-0.00
14
153
99
685
2.11
5.14
6.8
7.0
1.22
1.21
mmol/l
0.03
87
597
107
766
2.13
5.03
6.2
5.8
1.98
2.00
e9/l
0.06
92
683
90
607
2.06
4.94
4.5
3.5
6.32
6.22
ph
0.35
57
344
106
762
2.09
4.86
4.9
3.8
0.00
9.72
estimate
0.50
16
167
105
755
2.07
4.77
4.9
3.7
0.00
0.00
estimate
-0.00
16
164
85
574
1.99
4.53
4.9
3.6
0.00
0.00
estimate
-0.00
14
137
103
750
1.99
4.35
6.4
5.8
0.04
0.04
e9/l
0.16
89
647
102
747
1.96
4.16
6.4
5.8
0.55
0.56
e9/l
0.25
89
648
31
149
2.33
3.95
1.8
2.0
417.71
390.35
nmol/l
0.33
31
141
104
778
1.91
3.86
6.4
6.2
0.20
0.18
e9/l
0.40
91
691
21
85
2.69
3.81
1.5
3.1
—
—
—
0
0
36
188
2.17
3.77
2.1
2.0
—
—
—
0
0
57
353
1.94
3.76
1.8
2.1
2.82
2.76
mg/l
0.10
47
307
55
341
1.92
3.59
2.6
2.6
300.50
339.45
umol/l
1.92
50
302
64
418
1.87
3.56
4.1
3.0
—
—
—
0
0
62
405
1.85
3.43
5.8
3.8
0.00
0.00
estimate
-0.00
15
156
25
119
2.30
3.25
4.0
4.2
7.33
7.31
ph
0.10
18
83
94
706
1.77
3.20
6.6
5.6
30.48
28.05
%
1.43
88
681
55
356
1.82
3.08
4.6
4.2
—
—
—
0
0
133
1119
1.97
3.01
4.6
4.4
15.05
14.76
pmol/l
0.85
127
1025
25
123
2.22
3.01
2.8
2.1
10.21
10.46
g/l
0.13
20
113
65
445
1.76
3.01
3.0
2.6
56.29
67.54
u/l
0.54
59
412
74
527
1.73
2.97
4.1
3.6
18.03
29.10
ng/l
1.45
52
345
5
6
8.54
2.76
1.0
1.0
1768.00
1434.17
miu/ml
—
5
6
129
1086
1.86
2.76
10.0
8.1
74.71
78.20
u/l
0.56
124
1029
98
769
1.68
2.65
7.0
6.5
9.68
10.91
umol/l
1.25
93
732
89
682
1.66
2.63
3.1
2.7
—
—
estimate
—
0
0
90
692
1.66
2.62
6.8
5.6
8.62
8.49
%
0.17
85
660
76
561
1.66
2.58
2.4
2.0
—
—
—
0
0
50
332
1.73
2.51
6.1
3.8
1.02
1.02
kg/l
0.14
36
217
7
17
4.25
2.38
1.4
1.2
0.32
0.39
g/l
—
7
12
7
17
4.25
2.38
1.4
1.2
5.38
5.75
g/l
—
7
12
7
17
4.25
2.38
1.3
1.2
—
—
—
0
0
66
479
1.63
2.35
6.5
5.5
—
—
—
0
0
80
609
1.61
2.34
16.6
12.2
1.29
1.20
inr
0.71
68
508
88
687
1.60
2.31
6.7
5.6
0.75
0.65
%
1.27
83
649
64
463
1.62
2.30
3.6
3.1
8.10
7.67
mmol/l
0.29
57
395
88
688
1.60
2.29
6.8
5.6
3.09
2.81
%
0.50
83
654
148
1328
2.11
2.28
6.0
5.4
1.75
1.88
mu/l
0.95
143
1236
52
359
1.65
2.24
6.8
4.7
—
—
—
0
0
90
712
1.58
2.20
3.4
3.0
155.19
104.96
ug/l
0.73
85
671
7
19
3.80
2.17
1.1
1.3
—
—
—
0
0
49
336
1.65
2.15
1.7
1.8
2.75
1.09
mg/l
0.42
38
262
11
44
2.61
2.06
1.5
1.4
296.80
328.39
ug/g
—
5
27
6
15
4.11
2.06
1.2
3.8
—
—
—
0
0
60
444
1.55
1.90
3.0
3.1
0.00
0.00
estimate
-0.00
14
131
9
34
2.74
1.89
1.3
1.2
1.35
0.56
g/l
—
9
29
34
220
1.69
1.84
1.6
1.6
1305.96
1182.63
nmol/l
0.35
28
161
62
465
1.53
1.84
2.7
2.1
—
—
—
0
0
5
12
4.26
1.83
2.2
2.3
1.01
0.47
e9/l
—
5
12
64
484
1.53
1.83
4.2
3.4
2.36
2.36
mmol/l
0.09
59
448
7
23
3.13
1.82
1.4
1.2
—
—
—
0
0
59
442
1.52
1.75
5.8
6.8
—
—
—
0
0
5
13
3.93
1.72
1.0
2.3
21.98
41.91
ng/l
—
5
13
157
1479
2.27
1.70
18.7
12.7
—
—
—
0
0
83
670
1.48
1.70
12.1
10.7
0.00
0.00
e9/l
0.29
67
538
13
63
2.15
1.64
1.0
1.3
—
—
—
0
0
13
63
2.15
1.64
3.0
2.2
—
—
—
0
0
5
14
3.65
1.62
1.2
1.2
—
—
—
0
0
54
404
1.50
1.59
1.4
1.3
0.61
1.44
u/ml
1.27
22
112
154
1437
2.08
1.56
19.7
14.2
22.70
21.94
mg/l
0.11
136
1164
12
58
2.15
1.53
3.2
2.4
59.86
5210.26
u/l
—
7
19
26
165
1.68
1.52
1.9
1.6
—
—
—
0
0
33
223
1.60
1.52
3.8
2.6
117.98
126.87
ug/g
0.07
28
183
20
119
1.77
1.45
1.4
1.3
—
—
—
0
0
7
29
2.47
1.41
1.3
2.8
4.63
9.60
pmol/l
—
7
29
27
177
1.63
1.40
1.2
1.3
—
—
—
0
0
10
47
2.20
1.36
1.2
1.1
—
—
—
0
0
54
416
1.44
1.35
4.0
3.3
15.85
62.65
mg/l
2.10
36
264
9
43
2.15
1.32
3.8
3.4
7.41
7.42
ph
—
9
43
54
419
1.43
1.29
4.7
4.0
1.74
10.12
mg/mmol
2.80
37
260
67
541
1.40
1.28
5.3
4.0
16.93
65.13
e6/l
1.82
50
364
142
1314
1.58
1.21
4.5
4.1
1.28
1.25
mmol/l
0.23
135
1227
6
26
2.36
1.19
1.0
1.9
—
—
—
0
0
10
50
2.06
1.19
2.9
3.4
—
—
—
0
0
0
33
0.00
1.17
0.0
2.8
—
57.03
—
0
33
5
20
2.54
1.16
1.0
1.2
—
—
—
0
0
5
20
2.54
1.16
1.2
1.1
—
—
—
0
0
47
363
1.41
1.15
1.8
1.4
1.87
2.37
g/l
2.47
35
213
7
31
2.31
1.12
3.1
2.8
—
—
—
0
0
7
33
2.17
1.07
4.0
2.9
9.50
8.21
kpa
—
7
33
7
33
2.17
1.07
4.0
2.9
5.16
5.00
kpa
—
7
33
11
60
1.89
1.05
4.9
3.6
36.94
36.98
°c
0.23
11
60
18
116
1.62
1.01
6.0
3.7
0.60
0.16
%
—
5
25
7
36
1.99
0.98
1.0
1.1
—
—
—
0
0
7
36
1.99
0.98
1.0
1.1
—
—
—
0
0
21
142
1.55
0.98
6.4
7.9
4.80
5.08
kpa
0.87
21
137
21
142
1.55
0.98
6.4
8.0
7.40
7.42
ph
0.23
11
82
39
300
1.39
0.97
1.5
1.3
20.91
26.47
iu/ml
—
10
98
13
78
1.72
0.94
1.4
1.7
—
—
—
0
0
21
144
1.53
0.93
1.7
2.0
—
—
—
0
0
20
136
1.54
0.92
1.6
1.9
2.84
3.39
mmol/l
1.18
15
104
53
434
1.33
0.89
4.8
4.2
7.40
7.39
ph
0.78
39
311
49
402
1.31
0.81
4.0
3.1
1.77
0.37
e6/l
0.47
36
281
18
124
1.51
0.79
6.6
3.6
0.60
0.85
%
—
5
34
56
470
1.29
0.78
4.4
3.2
12.95
44.99
e6/l
1.86
44
347
12
75
1.65
0.77
1.0
1.1
—
—
—
0
0
19
135
1.46
0.73
1.5
1.5
—
—
—
0
0
69
599
1.26
0.73
2.3
2.0
104.06
97.84
pmol/l
0.49
41
317
14
93
1.55
0.72
1.6
1.2
—
—
—
0
0
29
225
1.35
0.69
1.3
1.4
297.14
417.50
titre
—
7
48
51
430
1.27
0.68
2.7
2.9
—
0.00
—
0
8
7
43
1.66
0.67
11.0
11.9
—
—
—
0
0
13
87
1.54
0.65
8.0
7.0
24.36
24.66
mmol/l
0.10
13
87
138
1309
1.33
0.64
7.7
6.0
39.85
38.78
mmol/mol
0.68
133
1249
11
71
1.59
0.64
4.0
4.6
—
—
—
0
0
22
166
1.38
0.62
1.7
1.4
—
—
—
0
0
5
30
1.69
0.62
1.6
1.1
—
10.73
—
0
10
8
51
1.60
0.61
1.4
1.4
1.04
1.20
g/l
—
8
51
33
271
1.27
0.54
1.5
1.3
19.12
5.58
u/ml
0.62
18
105
16
118
1.39
0.52
6.7
7.6
—
—
—
0
0
37
312
1.24
0.49
3.2
2.6
4.43
6.10
e6/l
0.55
37
285
7
47
1.51
0.48
1.0
1.1
—
—
—
0
0
7
47
1.51
0.48
2.4
1.4
12.91
6.96
u/l
—
7
39
43
371
1.22
0.46
2.4
2.1
—
—
—
0
0
7
49
1.45
0.46
1.6
1.4
0.21
0.23
g/l
—
7
49
27
223
1.25
0.43
4.6
3.2
0.32
2.84
e6/l
2.55
13
97
5
32
1.58
0.42
1.4
1.4
—
—
—
0
0
51
452
1.19
0.42
1.5
1.5
—
—
—
0
0
5
33
1.53
0.41
5.0
3.1
55.00
60.57
%
—
5
33
5
33
1.53
0.41
1.4
1.1
0.90
0.94
nmol/l
—
5
28
18
142
1.30
0.40
3.4
3.5
7.38
7.39
ph
0.36
12
78
8
61
1.33
0.40
1.1
1.3
—
—
—
0
0
8
61
1.33
0.40
1.1
2.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
111
1050
1.17
0.40
4.1
3.2
38.29
45.69
u/l
0.76
102
1005
26
217
1.24
0.38
1.8
1.6
—
—
—
0
0
9
69
1.32
0.38
1.3
2.2
—
—
—
0
0
9
70
1.30
0.37
1.1
1.6
—
—
—
0
0
128
1229
1.19
0.36
20.1
18.2
13.50
13.52
%
0.08
122
1222
6
42
1.44
0.36
1.2
1.3
—
2.97
—
0
10
22
262
0.82
0.34
3.8
3.5
13.54
167.47
ng/l
1.53
13
186
68
626
1.15
0.34
3.2
3.0
—
—
—
0
0
11
83
1.35
0.33
1.2
1.6
—
—
—
0
0
7
52
1.36
0.31
1.9
2.6
—
—
—
0
0
25
213
1.20
0.31
3.2
2.8
0.61
0.76
ug/l
0.91
16
114
11
84
1.33
0.31
1.3
1.6
—
—
—
0
0
11
84
1.33
0.31
1.3
1.6
—
—
—
0
0
11
84
1.33
0.31
1.3
1.6
—
—
—
0
0
7
56
1.26
0.30
1.6
1.2
—
—
—
0
0
9
74
1.23
0.25
4.7
2.3
0.84
0.63
%
—
9
74
6
85
0.69
0.24
1.0
1.1
—
—
—
0
0
11
136
0.80
0.24
1.3
1.2
—
—
—
0
0
64
601
1.11
0.22
2.1
2.0
1.31
1.39
mmol/l
0.44
58
510
33
298
1.13
0.21
1.6
1.8
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
8.4
—
7.31
—
0
10
0
12
0.00
0.21
0.0
18.8
—
957.83
—
0
12
0
12
0.00
0.21
0.0
2.3
—
10.35
—
0
12
10
80
1.27
0.21
1.2
1.6
—
—
—
0
0
23
207
1.13
0.16
1.5
1.6
—
—
—
0
0
20
179
1.13
0.15
1.4
1.4
—
—
—
0
0
16
180
0.88
0.14
1.1
1.4
—
—
—
0
0
10
117
0.85
0.13
3.2
2.3
13.04
14.11
nmol/l
—
10
112
138
1363
1.08
0.09
5.7
4.7
5.99
5.84
mmol/l
0.55
128
1273
5
62
0.80
0.08
3.2
1.6
46.60
34.92
nmol/l
—
5
62
9
84
1.08
0.07
1.8
3.1
23.21
24.44
mmol/l
—
9
84
22
209
1.06
0.04
1.8
1.9
—
—
—
0
0
16
151
1.07
0.03
1.9
1.4
—
—
—
0
0
12
117
1.03
0.00
4.6
3.4
—
—
—
0
0
20
195
1.03
0.00
1.2
1.3
—
—
—
0
0
11
108
1.02
0.00
1.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
10.1
—
16.18
—
0
8
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.5
—
—
—
0
0
0
8
0.00
0.00
0.0
3.3
—
3.94
—
0
8
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.9
—
121.62
—
0
8
5
53
0.94
-0.00
1.4
1.6
—
—
—
0
0
5
50
1.00
-0.00
1.6
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
0.00
—
0
9
0
7
0.00
-0.00
0.0
1.0
—
0.02
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
44.60
—
0
5
6
67
0.89
-0.00
1.8
2.1
1.31
1.57
g/l
—
6
61
0
6
0.00
-0.00
0.0
2.3
—
0.63
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
61.17
—
0
6
0
6
0.00
-0.00
0.0
1.7
—
28.83
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
14.52
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
53
0.94
-0.00
1.4
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
61.40
—
0
5

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_PELVIC_BONES_SACRUM_COCCYX and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_PELVIC_BONES_SACRUM_COCCYX.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: CD2_BENIGN_PELVIC_BONES_SACRUM_COCCYX – Benign neoplasm: Pelvic bones, sacrum and coccyx

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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