Benign neoplasm: Larynx

CD2_BENIGN_LARYNX

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D14.1&
  • Hospital discharge: ICD-9 2121
  • Hospital discharge: ICD-8 2121
  • Cause of death: ICD-10 D14.1&
  • Cause of death: ICD-9 2121
  • Cause of death: ICD-8 2121

2 out of 7 registries used, show all original rules.

1311

4. Check minimum number of events

None

1311

5. Include endpoints

None

1311

6. Filter based on genotype QC (FinnGen only)

1205

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D14
Name in latin
Neoplasma benignum laryngis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7637 2657 4895
Only index persons 6316 2327 3989
Unadjusted period prevalence (%)
Whole population 0.12 0.08 0.14
Only index persons 0.13 0.09 0.15
Median age at first event (years)
Whole population 55.93 55.72 55.94
Only index persons 54.31 54.47 54.22

-FinnGen-

Key figures

All Female Male
Number of individuals 1205 397 808
Unadjusted period prevalence (%) 0.29 0.14 0.37
Median age at first event (years) 56.69 52.51 58.74

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1239
Matched controls
12390
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
UDQ22
NOMESCO Finland
Microlaryngoscopy
105.7
307.7
304
38
D14.1
ICD-10 Finland
Benign neoplasm: Larynx
4503599627370496.0
307.7
1053
*
UDQ12
NOMESCO Finland
Flexible laryngoscopy
15.4
307.7
384
350
DQA10
NOMESCO Finland
Biopsy of larynx
109.2
307.7
224
25
DQB10
NOMESCO Finland
Endoscopic excision of lesion of larynx
245.9
307.7
482
32
C32.0
ICD-10 Finland
Malignant neoplasm: Glottis
114.5
295.5
151
15
ZXC10
NOMESCO Finland
Use of laser
22.8
281.6
215
113
D38.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Larynx
76.8
276.7
149
22
J38.3
ICD-10 Finland
Other diseases of vocal cords
33.0
242.8
159
55
J38.1
ICD-10 Finland
Polyp of vocal cord and larynx
55.7
228.2
130
26
J37.0
ICD-10 Finland
Chronic laryngitis
13.0
188.6
193
173
1420
FHL
Laryngomicroscopy
26.2
174.4
123
52
UDQ02
NOMESCO Finland
Direct laryngoscopy
32.4
147.3
96
32
21210
ICD-8 Finland
Benign neoplasm of respiratory system, Larynx
+∞
126.2
119
*
UJC01
NOMESCO Finland
Scopy of lower throat
21.2
125.6
96
49
B97.7
ICD-10 Finland
Papillomavirus as the cause of diseases classified to other chapters
235.5
125.3
127
6
2121A
ICD-9 Finland
Benign neoplasm of respiratory and intrathoracic organs, Larynx
+∞
112.2
106
*
QA1S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in head
34.9
99.1
63
19
8070/3-C32.0
ICD-O-3
Squamous cell carcinoma, NOS, of glottis
102.6
70.8
77
8
R49.0
ICD-10 Finland
Dysphonia
9.9
70.5
83
89
D14.0
ICD-10 Finland
Benign neoplasm: Middle ear, nasal cavity and accessory sinuses
15.5
70.3
62
42
R49.08
ICD-10 Finland
Other specified dysphonia
9.5
69.1
84
94
GDA98
NOMESCO Finland
Other bronchoscopic incision, excision of lesion or repair of lung
17.3
63.7
53
32
J38.2
ICD-10 Finland
Nodules of vocal cords
26.2
61.7
43
17
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
9.3
58.4
72
82
8070/3-C32.9
ICD-O-3
Squamous cell carcinoma, NOS, of larynx, NOS
106.9
56.4
61
6
UDH02
NOMESCO Finland
Rhinopharyngoscopy
4.2
54.6
161
428
WX408
NOMESCO Finland
General anesthesy, balanced
2.6
51.4
435
2146
UJC02
NOMESCO Finland
Rigid oesophagoscopy
14.9
51.3
46
32
J38.7
ICD-10 Finland
Other diseases of larynx
15.7
50.5
44
29
C32.9
ICD-10 Finland
Malignant neoplasm: Larynx, unspecified
475.0
46.6
46
*
R49.8
ICD-10 Finland
Other and unspecified voice disturbances
12.6
44.6
44
36
R49.09
ICD-10 Finland
Unspecified dysphonia
11.6
44.2
46
41
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.6
43.8
318
1441
R07.0
ICD-10 Finland
Pain in throat
4.1
42.5
125
330
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.3
41.9
182
623
R49.01
ICD-10 Finland
Functional dysphonia
5.8
41.5
79
145
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
7.7
41.4
59
80
A02BC05
ATC
esomeprazole; systemic
2.2
41.0
575
3463
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
9.3
40.9
50
56
WX734
NOMESCO Finland
JET-ventilation
54.2
39.8
47
9
EP1AE
NOMESCO Finland
Neck ultrasound examination
3.8
39.6
130
371
C32.1
ICD-10 Finland
Malignant neoplasm: Supraglottis
89.1
39.0
43
5
B977, D141,
ICD-10 Finland
+∞
37.7
36
*
ZXE00
NOMESCO Finland
One hour or less
2.1
36.4
549
3359
DQB30
NOMESCO Finland
Laryngectomy
190.5
36.0
37
*
JDB10
NOMESCO Finland
Percutaneous gastrostomy
7.8
35.0
49
65
C32.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of larynx
92.7
32.9
36
*
DQE00
NOMESCO Finland
Implantation of prosthetic replacement for larynx
120.0
32.8
35
*
WX402
NOMESCO Finland
General anaesthesia
2.3
32.3
325
1680
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.9
30.9
165
631
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
8.0
30.8
42
54
R13
ICD-10 Finland
Dysphagia
3.0
30.1
142
507
ZXD10
NOMESCO Finland
Scheduled procedure
2.0
29.8
518
3274
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.4
28.0
218
1003
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
6.6
27.9
45
70
DQB70
NOMESCO Finland
Total excision of vocal cord
102.4
27.8
30
*
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
4.3
26.7
71
173
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
26.7
415
2501
GBB00
NOMESCO Finland
Tracheostomy
6.2
24.8
43
72
GB3AV, ,
NOMESCO Finland
88.5
23.7
26
*
H02AB06
ATC
prednisolone; systemic
1.8
23.0
629
4489
A02BC02
ATC
pantoprazole; systemic
1.9
22.3
863
6814
WF002
NOMESCO Finland
Radical radiotherapy
2.8
22.2
115
431
R03BB04
ATC
tiotropium bromide; inhalant
2.2
19.3
181
893
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
19.2
431
2861
1430
FHL
Laryngoscopy (direct)
96.5
17.6
19
*
ZXE10
NOMESCO Finland
More than one and less than three hours
1.7
17.0
452
3122
ZXD20
NOMESCO Finland
Day surgery
2.1
16.3
168
857
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
2.6
16.3
98
396
Z50.5
ICD-10 Finland
Speech therapy
5.9
16.2
29
50
UDC00
NOMESCO Finland
Ear microscopy
2.5
16.1
111
478
A07AA02
ATC
nystatin; oral
2.7
16.1
89
345
R03AC02
ATC
salbutamol; inhalant
1.6
15.7
638
4885
8070/3-C32.1
ICD-O-3
Squamous cell carcinoma, NOS, of supraglottis
162.0
15.5
16
*
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
2.9
15.1
71
252
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.9
15.1
200
1116
R21
ICPC
Throat symptom/complaint
1.9
14.7
204
1157
4509
FHL
Other measure in this category
151.7
14.5
15
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
2.5
14.4
91
376
N07BA03
ATC
varenicline; oral
2.9
14.3
70
254
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.7
14.2
344
2295
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
2.6
14.2
87
355
J01DA01
ATC
[U] cefalexin
1.6
14.0
734
5907
R4130
NOMESCO Finland
Speech therapy
3.5
13.9
49
146
J39.2
ICD-10 Finland
Other diseases of pharynx
6.1
13.9
24
40
A02BC03
ATC
lansoprazole; oral
1.7
13.8
361
2455
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
13.8
619
4796
UJC12
NOMESCO Finland
Flexible oesophagoscopy
5.8
13.7
25
44
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
4.3
13.7
35
83
GD1AD
NOMESCO Finland
Thorax CT examination
2.3
13.5
103
464
A02BC01
ATC
omeprazole; systemic
1.7
13.5
339
2280
J02AC01
ATC
fluconazole; systemic
1.6
13.5
366
2511
R23
ICPC
Voice symptom/complaint
3.9
13.4
39
102
130
Kela drug reimbursment
Malignant tumour
2.0
13.3
147
769
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.6
13.2
604
4685
J04.0
ICD-10 Finland
Acute laryngitis
3.5
13.1
45
132
R95
ICPC
Chron obstructive pulmonary disease
3.0
12.9
59
206
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
4.9
12.9
28
58
WZC00
NOMESCO Finland
Treatment plan or consultation
1.6
12.9
427
3071
ZXB10
NOMESCO Finland
Medial
10.6
12.8
24
23
R04.2
ICD-10 Finland
Haemoptysis
2.8
12.7
64
236
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.1
12.7
131
668
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
2.4
12.6
91
400
DQE10
NOMESCO Finland
Injection of foreign material into vocal cord
15.6
12.6
20
13
JCA55
NOMESCO Finland
Endoscopic dilatation of oesophagus
5.5
12.6
24
44
JCW98
NOMESCO Finland
Other transluminal endoscopic procedure on oesophagus
70.6
12.6
14
*
UJF32
NOMESCO Finland
Coloscopy
1.6
12.6
332
2255
EBA15
NOMESCO Finland
Extraction of multiple teeth
2.7
12.5
69
267
C14.1
ICD-10 Finland
Malignant neoplasm of laryngopharynx unspecified
+∞
12.5
12
*
EP1DG
NOMESCO Finland
Very extensive examination of soft tissue of neck with high intesity magnet
9.1
12.3
25
28
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.6
12.3
468
3468
JC2AB
NOMESCO Finland
Oesophagus X-ray examination with contrast
4.8
12.2
27
57
UGB02
NOMESCO Finland
Tracheoscopy
27.0
12.1
16
6
J01AA02
ATC
doxycycline; systemic
1.6
11.7
923
7991
GBB13
NOMESCO Finland
Revision of tracheostomy
65.6
11.6
13
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
1.9
11.6
153
850
C320, 8077, 2
ICD-O-3
+∞
11.5
11
*
ENA10
NOMESCO Finland
Biopsy of pharynx
13.8
11.5
19
14
50808
ICD-8 Finland
Other diseases of upper respiratory tract, Alii definiti
11.9
11.3
20
17
D10.7
ICD-10 Finland
Benign neoplasm: Hypopharynx
20.2
11.1
16
8
XX9BW
NOMESCO Finland
Submitting image material and/or investigation material to authority or other institution
4.3
11.1
28
66
H02AB04
ATC
methylprednisolone; systemic
1.8
10.9
177
1048
R01AD08
ATC
fluticasone; nasal
1.6
10.7
299
2051
DQW99
NOMESCO Finland
Other operation on larynx
60.5
10.6
12
*
J45.9
ICD-10 Finland
Asthma, unspecified
1.7
10.6
221
1406
R06.0
ICD-10 Finland
Dyspnoea
1.6
10.6
346
2459
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
4.9
10.5
23
48
GD6AD
NOMESCO Finland
CT of chest and neck
14.3
10.5
17
12
A03FA01
ATC
metoclopramide; systemic, rectal
1.6
10.4
258
1715
D02.0
ICD-10 Finland
Carcinoma in situ: Larynx
+∞
10.4
10
*
J01MA12
ATC
levofloxacin; systemic
1.6
10.1
247
1638
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.6
10.0
237
1556
J38.4
ICD-10 Finland
Oedema of larynx
10.1
10.0
19
19
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.7
10.0
221
1427
N02AA05
ATC
oxycodone; systemic
1.6
10.0
251
1674
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
10.0
263
1775
J01FA10
ATC
azithromycin; systemic
1.5
9.9
587
4708
4784A
ICD-9 Finland
Other diseases of upper respiratory tract, Polyp of vocal cord or larynx[POLYPUS PLICAE VOCALIS]
12.3
9.9
17
14
4760A
ICD-9 Finland
Chronic laryngitis and laryngotracheitis, Chronic laryngitis
9.6
9.8
19
20
YA1VG
NOMESCO Finland
MRI examination of head and neck with high intesity magnet for dose design of radiotherapy
10.1
9.5
18
18
8070/2-C32.0
ICD-O-3
Squamous cell carcinoma in situ, NOS, of glottis
+∞
9.4
9
*
N02AX02
ATC
tramadol; systemic, rectal
1.5
9.4
522
4123
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.5
9.3
56
227
H02AB07
ATC
prednisone; oral
1.7
9.3
167
1019
D11.0
ICD-10 Finland
Benign neoplasm: Parotid gland
3.4
9.2
33
100
R49.03
ICD-10 Finland
Atrophic dysphonia
4.2
9.2
24
58
J01FA06
ATC
roxithromycin; oral
1.5
9.2
441
3380
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
4.6
9.1
21
46
R02
ICPC
Shortness of breath/dyspnoea
1.7
9.1
165
1009
D10.5
ICD-10 Finland
Benign neoplasm: Other parts of oropharynx
15.7
9.0
14
9
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
2.5
9.0
55
225
N05BA01
ATC
diazepam; systemic, rectal
1.7
8.9
157
951
ZXA10
NOMESCO Finland
Bilateral
1.6
8.9
212
1392
ZXA05
NOMESCO Finland
Left side
1.5
8.9
288
2034
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
8.7
8.8
18
21
F17.29
ICD-10 Finland
Addiction caused by tobacco UNS
3.5
8.8
30
88
R03AK03
ATC
[U] fenoterol and ipratropium bromide
2.1
8.7
86
431
C13.9
ICD-10 Finland
Malignant neoplasm: Hypopharynx, unspecified
50.3
8.7
10
*
JN4KR
NOMESCO Finland
Whole body very extensive metabolic PET with CT
6.7
8.7
21
32
J01DB01
ATC
cefalexin; oral
1.5
8.6
949
8470
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.8
8.5
126
725
C32.2
ICD-10 Finland
Malignant neoplasm: Subglottis
90.7
8.4
9
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.5
8.4
356
2653
DQB00
NOMESCO Finland
Excision of lesion of larynx
+∞
8.3
8
*
A02BA02
ATC
ranitidine; systemic
1.6
8.3
229
1558
R03BA05
ATC
fluticasone; inhalant
1.6
8.2
192
1254
R03AL08
ATC
vilanterol, umeclidinium bromide and fluticasone furoate; inhalant
3.2
8.1
32
103
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
2.7
8.1
42
158
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.3
7.9
56
245
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.6
7.9
225
1538
Z72.0
ICD-10 Finland
Tobacco use
2.9
7.9
37
132
H03AA01
ATC
levothyroxine sodium; systemic
1.6
7.9
220
1499
N06AX16
ATC
venlafaxine; oral
1.7
7.8
140
851
EP1BG
NOMESCO Finland
MRI examination of soft tissue of neck with high intesity magnet
10.9
7.8
14
13
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
2.4
7.6
50
212
JN4JR
NOMESCO Finland
Whole body extensive metabolic PET with CT
4.1
7.6
20
49
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
1.7
7.5
146
909
N05CF01
ATC
zopiclone; oral
1.4
7.5
370
2831
C32
ICD-10 Finland
Malignant neoplasm of larynx
+∞
7.3
7
*
SPAT1301
SPAT
No procedures
1.4
7.3
338
2553
N03AX16
ATC
[U] pregabalin
1.5
7.3
252
1797
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
3.0
7.3
31
105
K08.3
ICD-10 Finland
Retained dental root
1.8
7.2
101
571
YA1CD
NOMESCO Finland
Very extensive CT examination of head and neck for dose design of radiotherapy
15.8
7.2
11
7
WX400
NOMESCO Finland
Inhalation anesthesy
2.4
7.2
48
205
R03DC03
ATC
montelukast; oral
1.6
7.1
162
1049
M54.5
ICD-10 Finland
Low back pain
1.4
7.1
386
2997
M01AE03
ATC
ketoprofen; systemic, rectal
1.4
7.0
414
3259
78559
ICD-8 Finland
Symptoms referable to abdomen and lower gastro-intestinal tract, Colica abdominalis NUD
2.7
7.0
35
130
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.7
6.9
134
832
J31.0
ICD-10 Finland
Chronic rhinitis
1.9
6.9
92
512
A01AB09
ATC
miconazole; local oral
1.8
6.9
94
527
ZX070
NOMESCO Finland
Intensity modified radiotherapy
3.0
6.9
30
103
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.5
6.9
201
1381
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.6
6.9
163
1067
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.6
6.8
165
1084
J05.1
ICD-10 Finland
Acute epiglottitis
11.0
6.8
12
11
WX002
NOMESCO Finland
Sedation and analgesia
1.5
6.8
219
1538
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.8
6.8
98
561
M02AA07
ATC
piroxicam; topical
1.4
6.7
391
3067
N02AJ06
ATC
codeine and paracetamol; systemic
1.4
6.7
464
3746
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.4
6.7
318
2406
J01FA09
ATC
clarithromycin; systemic
1.4
6.7
309
2326
XX3DW
NOMESCO Finland
Time consuming IT work
1.7
6.6
129
803
J01CE02
ATC
phenoxymethylpenicillin; oral
1.4
6.6
734
6387
GD6BD
NOMESCO Finland
Extensive CT of chest and neck
10.1
6.5
12
12
J20
ICD-10 Finland
Acute bronchitis
1.7
6.5
113
681
EJA10
NOMESCO Finland
Biopsy of tongue or floor of mouth
3.0
6.5
27
90
ZXA00
NOMESCO Finland
Right side
1.4
6.4
299
2252
J01CA04
ATC
amoxicillin; systemic
1.4
6.4
905
8162
M54.4
ICD-10 Finland
Lumbago with sciatica
1.5
6.4
189
1301
M48.0
ICD-10 Finland
Spinal stenosis
1.6
6.3
153
1005
SPAT1263
SPAT
Sampling
1.4
6.3
434
3492
C01
ICD-10 Finland
Malignant neoplasm of base of tongue
18.1
6.3
9
5
P01AB01
ATC
metronidazole; oral, rectal
1.4
6.2
401
3191
R03BA02
ATC
budesonide; inhalant
1.5
6.2
186
1286
R01AD09
ATC
mometasone; nasal
1.4
6.1
445
3608
E0000UV, ,
ATC
1.4
6.1
427
3440
UJD02
NOMESCO Finland
Gastroscopy
2.0
6.1
61
308
R05
ICD-10 Finland
Cough
1.5
6.1
219
1568
J45
ICD-10 Finland
Asthma
1.7
6.1
103
618
M70.6
ICD-10 Finland
Trochanteric bursitis
1.6
6.1
128
814
ZXE40
NOMESCO Finland
More than seven and less than nine hours
2.7
6.0
30
111

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
615
3931
2.12
36.32
3.0
2.2
—
—
—
0
0
736
5920
1.60
14.12
9.6
10.1
4.42
4.24
e9/l
0.72
651
5111
167
927
1.93
12.71
1.5
1.4
—
—
—
0
0
292
1925
1.68
12.42
4.7
3.6
0.80
0.82
mmol/l
2.67
281
1819
616
4858
1.53
12.11
5.5
5.5
35.15
35.16
g/l
0.03
577
4573
671
5416
1.52
11.66
6.9
6.6
2.05
1.93
e9/l
0.37
599
4753
700
5718
1.52
11.37
7.3
7.1
12.42
12.15
umol/l
0.10
668
5480
660
5329
1.51
11.30
15.8
16.9
1.27
1.30
inr
0.67
568
4451
657
5321
1.50
10.94
6.8
6.5
0.63
0.61
e9/l
0.76
570
4529
481
3665
1.51
10.71
3.9
3.6
31.69
104.72
e6/l
2.46
383
2846
657
5336
1.49
10.69
6.9
6.5
0.04
0.04
e9/l
0.35
572
4542
674
5507
1.49
10.62
7.1
6.8
0.19
0.20
e9/l
1.28
598
4793
910
7957
1.54
9.99
10.0
8.8
83.67
80.72
u/l
0.42
871
7556
221
1436
1.66
9.72
1.4
1.3
—
—
—
0
0
352
2566
1.52
9.42
3.1
2.8
4.09
4.38
e6/l
0.23
315
2342
606
4938
1.44
9.13
7.2
6.7
2.71
2.87
%
1.08
572
4625
605
4939
1.44
8.96
7.3
6.7
0.62
0.67
%
1.43
571
4622
605
4940
1.44
8.95
7.0
6.6
58.74
57.99
%
0.76
580
4715
601
4906
1.44
8.88
3.0
3.0
—
—
estimate
—
0
0
603
4947
1.43
8.55
7.2
6.8
9.14
9.11
%
0.10
572
4633
411
3142
1.46
8.54
3.6
3.5
0.28
0.47
e6/l
2.29
312
2350
611
5033
1.42
8.42
7.3
6.7
26.09
26.60
%
0.50
583
4772
203
1341
1.61
8.29
1.9
1.8
—
—
—
0
0
752
6440
1.43
8.26
6.1
5.7
6.66
6.81
mmol/l
1.56
735
6152
503
4069
1.40
7.38
4.4
4.2
42.47
121.42
e6/l
2.49
389
2963
431
3428
1.39
6.86
2.9
2.8
55.91
83.98
u/l
0.64
403
3194
452
3627
1.39
6.82
6.9
6.5
—
—
—
0
0
769
6725
1.38
6.76
5.9
4.7
345.00
843.92
e6/l
0.53
15
104
645
5490
1.36
6.69
8.3
7.9
1.21
1.21
mmol/l
0.12
544
4733
200
1385
1.53
6.58
1.4
1.3
—
—
—
0
0
372
2903
1.40
6.57
2.5
2.3
2.86
2.92
mg/l
0.14
333
2495
829
7398
1.36
6.04
4.8
4.0
15.03
14.86
pmol/l
1.18
752
6713
450
3684
1.35
5.75
3.4
3.6
2.35
2.35
mmol/l
0.48
415
3333
584
4984
1.32
5.56
7.3
7.2
1.20
1.21
mmol/l
0.04
547
4606
169
1170
1.51
5.55
3.2
2.4
164.56
132.80
ug/g
0.35
132
942
284
2175
1.40
5.47
3.0
3.2
2.46
2.45
mmol/l
1.09
254
1958
227
1676
1.43
5.37
2.6
2.8
20.66
22.88
%
1.56
217
1576
241
1805
1.42
5.26
2.5
2.7
2.35
2.25
g/l
1.66
233
1686
412
3364
1.34
5.25
4.7
4.7
—
—
—
0
0
183
1304
1.47
5.21
1.6
1.5
—
—
—
0
0
565
4833
1.31
5.16
2.2
2.2
95.21
94.15
pmol/l
0.19
313
2641
254
1931
1.40
5.08
2.6
2.8
11.79
12.85
umol/l
1.53
243
1818
423
3496
1.32
4.89
2.5
2.7
—
—
—
0
0
92
573
1.65
4.76
5.2
3.9
—
—
—
0
0
38
177
2.18
4.75
2.4
2.5
—
—
—
0
0
144
998
1.50
4.70
3.0
2.6
5.52
7.27
ug/l
1.01
132
893
343
2768
1.33
4.64
4.2
4.4
86.57
86.17
%
0.10
338
2723
177
1285
1.44
4.57
2.8
3.0
11.08
8.54
umol/l
0.30
157
1159
192
1417
1.42
4.53
2.3
2.7
1.84
1.81
%
0.17
179
1287
220
1663
1.39
4.52
1.9
2.2
—
—
—
0
0
331
2669
1.33
4.49
2.7
2.6
—
—
—
0
0
294
2330
1.34
4.48
1.8
1.7
1.07
1.40
mg/l
1.75
235
1835
1044
9822
1.40
4.43
23.6
18.2
25.66
26.76
mg/l
0.53
932
8241
536
4625
1.28
4.33
3.4
3.1
158.12
152.81
ug/l
0.10
509
4293
154
1100
1.46
4.33
2.7
2.8
73.78
69.28
e9/l
0.85
119
826
966
8992
1.34
4.28
6.1
5.0
1.99
1.97
mu/l
0.09
891
8227
281
2229
1.34
4.24
4.6
4.2
332.74
348.22
ng/l
0.06
220
1862
120
821
1.51
4.18
5.3
3.9
7.41
7.42
ph
0.61
108
694
56
316
1.81
4.13
1.7
1.6
22.01
14.20
u/ml
0.46
13
64
45
239
1.92
4.01
4.7
5.3
2.93
2.48
mmol/l
0.37
30
162
49
270
1.85
3.92
4.2
4.3
—
—
—
0
0
56
325
1.76
3.79
5.4
3.4
7.31
7.98
kpa
2.37
56
319
282
2280
1.31
3.68
4.6
4.9
—
—
—
0
0
49
276
1.81
3.67
3.8
3.2
87.31
89.09
%
0.85
49
267
243
1936
1.32
3.51
1.5
1.5
2.81
2.62
g/l
0.35
166
1200
119
844
1.45
3.50
4.1
4.0
—
—
—
0
0
112
788
1.46
3.43
9.7
9.9
25.50
24.81
mmol/l
1.24
112
783
80
524
1.56
3.43
2.4
2.4
—
—
—
0
0
69
439
1.61
3.35
4.0
3.0
25.72
24.75
mmol/l
1.12
69
433
127
922
1.42
3.30
3.6
4.5
0.58
0.73
%
0.41
48
306
495
4331
1.24
3.29
5.2
4.1
38.43
84.48
ng/l
1.31
365
3262
203
1591
1.33
3.29
6.0
6.4
1.06
1.04
mmol/l
0.39
189
1479
419
3602
1.25
3.27
3.5
3.3
1191.09
1636.47
ng/l
2.22
361
3103
99
687
1.48
3.26
1.8
1.8
1.37
1.46
g/l
0.16
90
641
767
7036
1.24
3.24
5.5
4.5
—
2.46
—
0
11
405
3472
1.25
3.23
2.5
2.3
214.41
235.89
u/l
0.25
388
3301
387
3303
1.25
3.21
4.7
4.4
7.40
7.40
ph
0.32
289
2392
240
1932
1.30
3.21
1.8
1.8
1250.29
1155.28
nmol/l
0.77
190
1445
34
179
1.92
3.16
3.5
3.1
4.38
4.45
e9/l
0.05
34
179
370
3147
1.25
3.15
7.4
6.4
—
—
—
0
0
24
111
2.19
3.14
1.3
1.2
—
—
—
0
0
78
523
1.52
3.04
1.7
1.9
2.45
1.97
ug/l
0.16
70
470
118
860
1.41
3.02
2.3
2.9
10.08
10.98
g/l
1.27
109
794
359
3058
1.24
3.00
3.9
3.3
—
—
—
0
0
136
1022
1.37
2.91
4.9
4.5
7.36
7.35
ph
0.16
112
760
226
1834
1.28
2.83
3.6
3.3
1.80
1.42
e6/l
0.27
113
949
240
1966
1.27
2.79
3.4
3.2
1.04
0.91
e6/l
0.20
130
1079
1060
10150
1.31
2.79
26.3
21.8
139.51
139.69
mmol/l
1.56
1045
9952
504
4477
1.21
2.77
2.5
2.4
75.83
76.58
nmol/l
0.24
464
3996
24
118
2.05
2.72
1.8
1.2
0.22
0.19
nmol/l
0.69
19
93
124
929
1.37
2.71
3.3
3.2
386.80
224.18
ng/l
0.43
112
848
204
1650
1.28
2.62
1.3
1.3
13.88
10.65
u/ml
0.20
73
596
221
1808
1.27
2.59
1.9
2.1
29.40
29.79
s
0.50
215
1756
145
1122
1.33
2.58
2.7
2.3
0.20
0.21
g/l
0.49
137
1039
175
1393
1.30
2.55
1.4
1.3
488.00
440.77
titre
0.13
45
313
15
62
2.44
2.54
1.9
1.6
142.67
109.34
ng/l
0.33
15
62
122
923
1.36
2.52
3.9
5.1
0.02
0.12
%
1.33
45
257
1059
10167
1.29
2.52
26.7
22.0
4.00
4.00
mmol/l
0.20
1045
9954
128
977
1.35
2.50
2.1
2.1
0.10
0.03
estimate
0.32
20
193
725
6702
1.20
2.50
4.1
3.5
62.84
55.59
u/l
0.59
680
6298
156
1228
1.31
2.47
1.5
1.4
—
—
—
0
0
1074
10340
1.29
2.42
14.6
12.7
27.29
27.25
u/l
0.02
1049
10045
262
2203
1.24
2.42
3.2
3.0
529.83
548.67
mosm/kgh2o
0.79
228
1926
54
354
1.55
2.39
4.0
7.5
1.09
1.35
mmol/l
2.60
48
309
402
3543
1.20
2.31
3.9
3.5
32.60
34.79
u/l
0.51
381
3355
1084
10462
1.29
2.30
29.1
23.6
83.17
83.36
umol/l
0.05
1074
10330
33
193
1.73
2.28
5.2
2.9
—
—
—
0
0
212
1761
1.25
2.19
1.3
1.3
46.08
33.00
iu/ml
0.33
63
540
29
166
1.76
2.16
2.6
2.7
—
—
—
0
0
59
404
1.48
2.16
1.2
1.2
—
—
—
0
0
339
2966
1.20
2.09
3.3
3.0
351.18
358.78
umol/l
0.57
297
2598
74
534
1.41
2.07
1.5
1.2
—
—
—
0
0
600
5513
1.17
2.06
4.4
3.9
0.03
0.29
estimate
0.44
125
1082
348
3056
1.19
2.05
4.5
4.1
0.00
0.01
estimate
0.96
121
1055
150
1206
1.28
2.04
3.8
4.0
1.66
1.87
mmol/l
0.26
133
1027
28
162
1.75
2.03
3.9
2.2
345.93
9141.14
u/l
—
10
55
481
4347
1.17
2.02
3.9
3.5
6.22
6.20
ph
0.15
263
2459
37
232
1.61
2.01
3.6
3.1
60.71
58.19
%
0.57
37
232
19
97
1.97
2.01
1.1
1.2
—
—
—
0
0
184
1521
1.25
1.99
1.8
1.8
—
—
—
0
0
84
626
1.37
1.96
1.2
1.3
41.90
52.93
au/ml
—
6
53
78
577
1.38
1.91
1.5
1.9
1.64
1.50
g/l
0.65
68
516
85
638
1.36
1.90
1.3
1.3
223.18
271.81
u/ml
0.20
80
588
455
4111
1.17
1.89
4.2
3.8
4.44
0.02
estimate
0.49
113
969
21
114
1.86
1.88
2.0
1.3
—
—
nmol/l
—
0
0
594
5485
1.16
1.84
4.2
3.9
0.00
4.46
estimate
1.08
136
1177
116
918
1.29
1.81
3.6
4.8
0.13
0.12
%
0.03
40
276
21
363
0.57
1.80
1.7
1.7
—
—
—
0
0
587
5423
1.16
1.80
4.3
3.8
0.00
0.00
estimate
-0.00
134
1157
175
1456
1.24
1.79
7.8
8.8
5.14
5.12
kpa
0.10
170
1402
173
1438
1.24
1.79
7.7
8.9
1.30
0.91
mmol/l
0.69
144
1183
175
1457
1.23
1.78
7.8
8.8
11.97
11.94
kpa
0.02
169
1407
174
1450
1.23
1.76
7.9
8.9
7.42
7.41
ph
1.24
106
826
101
788
1.31
1.76
2.6
2.5
6.11
6.05
ph
0.28
74
543
135
1094
1.26
1.75
8.5
9.9
—
—
—
0
0
89
683
1.33
1.74
2.4
2.5
18.76
20.18
au/ml
0.06
11
68
247
2134
1.20
1.74
1.4
1.3
1.39
1.57
u/ml
0.15
69
587
121
972
1.27
1.69
3.6
4.7
0.67
0.93
%
0.83
43
329
104
820
1.29
1.68
2.3
2.7
—
—
—
0
0
45
309
1.47
1.68
3.9
3.6
2.34
1.92
index
0.17
27
177
19
104
1.84
1.68
3.0
3.8
13.00
11.52
index
0.38
14
67
41
277
1.50
1.65
1.1
1.2
—
—
—
0
0
5
14
3.58
1.61
1.0
1.2
—
—
—
0
0
59
430
1.39
1.61
2.7
2.7
9.91
10.95
g/l
1.03
52
387
151
1253
1.23
1.60
3.7
4.0
7.38
7.38
ph
0.03
90
739
7
26
2.70
1.58
1.9
1.2
—
—
—
0
0
37
248
1.51
1.56
3.6
2.9
15.59
16.17
%
0.52
37
242
10
44
2.28
1.55
1.0
1.3
191.70
182.29
mmol/24h
—
10
44
41
284
1.46
1.49
2.2
2.5
105.95
105.46
ug/min
0.00
21
169
53
386
1.39
1.47
2.8
3.8
5.09
2.49
ratio
0.44
27
220
9
38
2.38
1.45
2.8
2.8
0.57
0.61
mmol/l
—
9
38
1091
10635
1.22
1.45
33.9
27.1
245.53
241.83
e9/l
0.97
1074
10415
1091
10635
1.22
1.45
33.7
27.0
91.37
91.44
fl
0.21
1080
10509
990
9573
1.17
1.43
6.0
5.4
6.05
6.05
mmol/l
0.01
909
8734
1091
10638
1.21
1.43
34.5
27.8
40.17
40.51
%
1.16
1081
10504
1091
10638
1.21
1.43
33.7
27.0
30.38
30.46
pg
0.77
1080
10510
1091
10638
1.21
1.43
33.8
27.1
4.46
4.50
e12/l
1.37
1070
10379
1091
10640
1.21
1.41
33.8
27.2
7.09
6.85
e9/l
2.01
1071
10382
1091
10640
1.21
1.41
34.1
27.3
134.45
135.88
g/l
2.17
1081
10515
125
1033
1.23
1.40
1.7
1.5
—
—
—
0
0
1034
10041
1.18
1.38
19.4
16.2
—
—
—
0
0
21
127
1.66
1.37
5.7
2.6
—
—
—
0
0
29
192
1.52
1.33
2.5
2.0
1.78
1.69
mmol/l
0.22
29
186
323
2913
1.15
1.32
3.5
3.3
2.27
0.05
estimate
0.48
110
905
493
4573
1.13
1.31
14.9
12.2
0.00
0.00
e9/l
0.68
412
3705
100
814
1.25
1.30
3.2
4.0
84.29
95.99
ng/l
0.79
89
713
56
422
1.34
1.29
2.9
4.0
30.98
76.78
mg/l
1.00
46
360
56
423
1.34
1.28
2.9
4.0
47.65
67.18
mg/l
0.66
45
360
21
130
1.63
1.27
1.1
1.1
0.19
1.06
u/ml
—
8
63
150
1277
1.20
1.27
1.7
1.6
—
—
—
0
0
146
1241
1.20
1.25
3.7
3.9
5.82
5.85
kpa
0.15
141
1210
5
116
0.43
1.25
1.8
2.2
—
—
—
0
0
67
523
1.30
1.22
3.1
3.7
4.31
4.48
pmol/l
0.74
62
461
61
470
1.31
1.22
1.3
1.3
—
—
—
0
0
135
1143
1.20
1.21
8.3
7.9
9.62
10.50
mmol/l
0.82
130
1101
419
3864
1.13
1.21
4.2
3.5
7.37
7.90
mmol/l
1.79
358
3237
21
132
1.60
1.21
1.1
1.1
3.33
4.43
u/ml
—
10
76
66
518
1.29
1.17
3.1
2.8
—
—
—
0
0
972
9429
1.14
1.16
7.5
6.9
39.88
39.89
mmol/mol
0.01
908
8774
23
150
1.54
1.15
1.1
1.1
0.37
1.96
u/ml
—
10
90
20
126
1.60
1.15
1.1
1.1
—
—
—
0
0
151
1301
1.18
1.13
4.2
3.5
5.37
5.06
e9/l
0.14
128
1126
29
200
1.46
1.13
1.0
1.4
—
10.68
—
0
5
100
829
1.22
1.12
9.7
10.8
1.66
1.30
%
2.41
100
824
7
30
2.34
1.12
2.1
1.4
90.57
83.63
nmol/24h
—
7
30
19
119
1.61
1.12
1.2
1.2
—
—
—
0
0
30
209
1.45
1.11
1.2
1.8
—
—
—
0
0
125
1062
1.20
1.10
2.5
2.6
31.17
37.69
u/l
0.71
93
891
22
144
1.54
1.09
1.9
2.4
0.97
1.45
g/24h
0.46
12
85
400
3700
1.12
1.09
3.7
3.5
48.23
53.27
mg/l
0.24
272
2477
5
22
2.28
1.03
1.0
1.0
—
—
—
0
0
837
8070
1.11
1.03
27.4
23.4
332.38
332.67
g/l
0.37
832
8022
7
34
2.06
1.03
1.9
2.1
—
—
—
0
0
24
163
1.48
1.02
1.7
1.6
—
—
—
0
0
24
163
1.48
1.02
1.7
1.6
—
—
—
0
0
24
163
1.48
1.02
1.7
1.6
—
—
—
0
0
24
163
1.48
1.02
1.7
1.6
—
—
—
0
0
92
766
1.22
1.01
1.7
1.4
—
—
—
0
0
22
147
1.51
1.01
1.2
1.3
—
—
—
0
0
15
91
1.66
1.00
1.6
1.2
—
—
—
0
0
836
8070
1.11
0.98
25.2
22.3
13.92
13.73
%
3.03
829
7966
102
863
1.20
0.96
4.7
4.0
1.21
1.22
mmol/l
0.72
93
746
13
77
1.70
0.95
1.2
1.6
75.62
84.52
umol/l
0.99
13
77
14
85
1.65
0.94
1.6
1.5
—
—
—
0
0
6
27
2.23
0.93
1.7
1.1
—
—
—
0
0
62
759
0.81
0.89
1.3
1.4
—
—
—
0
0
34
254
1.35
0.89
6.0
2.2
—
—
—
0
0
29
212
1.38
0.87
6.4
2.1
—
—
—
0
0
124
1079
1.17
0.86
1.6
1.6
—
—
—
0
0
404
3782
1.10
0.86
4.5
4.2
9.82
9.48
mg/mmol
0.05
268
2447
33
247
1.35
0.86
3.4
3.3
0.74
0.85
nmol/l
0.98
26
202
40
310
1.30
0.83
1.3
1.2
40.00
95.81
titre
—
5
31
18
121
1.49
0.83
1.7
4.2
—
—
—
0
0
8
46
1.74
0.82
1.6
1.9
40.77
39.93
g/l
—
8
46
34
258
1.33
0.82
1.4
1.7
—
—
—
0
0
54
663
0.81
0.81
2.1
1.8
3.66
3.53
mmol/l
0.29
38
501
18
122
1.48
0.80
1.4
1.5
24.56
34.59
ng/l
0.48
18
122
8
48
1.67
0.79
1.0
1.1
520.78
242.43
iu/ml
—
8
48
18
123
1.47
0.77
1.1
1.1
0.57
2.58
u/ml
1.41
11
72
58
476
1.23
0.77
2.7
1.7
0.35
0.34
mg/l
0.04
31
238
6
34
1.77
0.76
3.0
2.8
11.05
264.21
ug/l
—
6
28
346
3234
1.10
0.76
1.8
1.8
18.37
19.83
nmol/l
1.20
310
2746
5
25
2.00
0.72
2.6
1.7
—
—
—
0
0
7
39
1.80
0.72
1.0
1.4
—
—
—
0
0
7
39
1.80
0.72
4.6
3.2
—
—
—
0
0
51
417
1.23
0.71
1.2
1.1
—
43.60
—
0
10
7
40
1.75
0.71
1.4
1.6
0.14
0.08
estimate
—
7
40
9
57
1.58
0.71
1.3
1.3
137.56
456.79
u/l
—
9
52
5
26
1.93
0.70
1.4
2.1
—
—
—
0
0
5
26
1.93
0.70
1.0
1.3
26.00
28.04
s
—
5
26
532
5081
1.08
0.70
5.7
5.6
3.20
3.57
ug/l
0.14
479
4577
15
101
1.49
0.70
1.1
1.1
0.90
4.12
u/ml
—
7
51
114
1005
1.15
0.70
2.4
3.0
66.28
66.35
g/l
0.04
103
926
9
58
1.56
0.70
1.1
1.1
—
—
—
0
0
13
85
1.54
0.69
1.6
1.4
191.82
155.14
pmol/l
1.07
13
85
58
484
1.21
0.68
2.4
1.8
—
—
—
0
0
35
276
1.28
0.67
6.0
2.1
—
—
—
0
0
35
276
1.28
0.67
6.1
2.1
—
—
—
0
0
37
294
1.27
0.67
1.2
1.2
—
—
—
0
0
5
28
1.79
0.66
1.2
1.0
—
—
—
0
0
5
28
1.79
0.66
1.4
1.1
—
—
—
0
0
5
28
1.79
0.66
5.2
3.7
6.20
5.14
ug/l
—
5
28
13
86
1.52
0.66
2.2
2.1
37.42
38.01
%
0.04
13
86
13
86
1.52
0.66
1.3
2.0
4.60
1.62
u/field
—
5
47
67
569
1.19
0.66
1.2
1.2
55.96
141.62
u/ml
2.91
23
219
246
2282
1.10
0.64
1.7
1.8
48756648.71
31124497.21
pmol/l
0.14
201
1886
14
95
1.48
0.64
1.1
1.1
0.28
0.44
u/ml
—
7
41
28
216
1.30
0.63
3.3
3.7
24.85
29.00
mg/l
0.25
21
148
260
2420
1.09
0.63
5.1
4.1
1.02
1.02
kg/l
0.57
173
1644
22
291
0.75
0.63
1.1
1.2
1.38
1.50
g/l
1.33
22
291
5
30
1.67
0.61
1.0
1.4
10.16
8.17
mmol/l
—
5
30
984
9659
1.09
0.60
5.5
5.2
1.36
1.40
mmol/l
2.30
913
8906
9
141
0.64
0.60
1.1
1.4
—
—
—
0
0
15
105
1.43
0.60
1.3
1.2
—
—
—
0
0
0
21
0.00
0.60
0.0
1.0
—
8.69
—
0
13
133
1200
1.12
0.59
3.4
4.4
11.79
24.11
ug/l
0.62
110
1003
24
309
0.77
0.58
1.4
1.2
0.85
0.90
g/l
0.47
24
309
6
35
1.72
0.57
3.5
4.4
—
—
—
0
0
34
275
1.24
0.55
6.2
2.0
—
—
—
0
0
28
221
1.27
0.55
1.1
1.2
73.45
46.13
u/l
0.36
21
191
944
9262
1.08
0.55
4.7
4.5
1.41
1.32
mmol/l
2.96
875
8468
14
99
1.42
0.54
1.1
1.2
—
—
—
0
0
73
638
1.15
0.53
1.2
1.3
—
—
—
0
0
40
332
1.21
0.52
1.7
1.5
250.57
270.58
ug/g
0.25
24
195
21
271
0.77
0.52
1.1
1.1
—
0.70
—
0
38
10
66
1.52
0.52
3.8
2.3
74.70
72.10
%
—
10
61
1003
9871
1.08
0.52
6.5
6.1
2.60
2.63
mmol/l
0.43
928
9111
24
303
0.79
0.51
20.0
12.6
—
—
—
0
0
19
144
1.32
0.50
1.4
1.2
1.91
5.40
u/ml
1.47
11
65
9
65
1.39
0.50
2.0
1.7
—
—
—
0
0
7
46
1.52
0.48
4.6
3.1
—
—
—
0
0
13
93
1.40
0.48
1.0
1.2
—
—
—
0
0
5
81
0.62
0.46
1.6
1.5
—
—
—
0
0
5
83
0.60
0.45
2.6
1.9
—
—
—
0
0
5
84
0.59
0.45
1.6
1.6
—
—
—
0
0
14
103
1.36
0.45
2.3
2.3
—
—
—
0
0
27
330
0.81
0.45
1.1
1.2
—
—
—
0
0
21
166
1.27
0.43
1.1
1.1
—
—
—
0
0
21
166
1.27
0.43
1.1
1.1
—
—
—
0
0
986
9719
1.07
0.43
5.7
5.3
4.46
4.50
mmol/l
0.47
924
9028
5
31
1.62
0.43
1.2
1.0
—
7.33
—
0
7
22
273
0.80
0.42
4.0
3.2
1.37
1.56
mmol/l
0.86
22
264
5
32
1.56
0.42
1.0
1.6
—
—
—
0
0
5
32
1.56
0.42
2.8
2.2
38.20
32.47
%
—
5
32
6
95
0.63
0.42
1.2
1.1
287.50
279.17
mg/l
—
6
87
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
5
34
1.47
0.40
1.0
1.1
—
—
—
0
0
5
34
1.47
0.40
1.0
1.1
—
—
—
0
0
5
34
1.47
0.40
1.0
1.1
—
—
—
0
0
11
149
0.74
0.40
1.4
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
7
101
0.69
0.39
3.7
2.6
—
—
—
0
0
5
35
1.43
0.39
1.6
1.1
—
25.40
—
0
5
5
35
1.43
0.39
1.4
1.7
—
—
—
0
0
14
106
1.32
0.39
1.7
1.1
—
—
—
0
0
32
270
1.19
0.38
6.5
2.2
—
—
—
0
0
13
169
0.77
0.37
1.1
1.4
7790.50
1562.77
e6/l
—
8
116
17
134
1.27
0.37
1.4
1.2
—
—
—
0
0
25
207
1.21
0.36
1.1
1.2
198.93
281.05
u/ml
1.23
15
114
6
43
1.40
0.35
1.0
1.0
1153.50
1480.21
miu/ml
—
6
43
6
44
1.37
0.34
2.2
1.3
—
—
—
0
0
14
109
1.29
0.33
1.1
1.1
3.31
3.52
u/ml
—
7
59
21
253
0.83
0.33
3.2
4.4
—
—
—
0
0
6
46
1.31
0.33
1.0
1.1
—
—
—
0
0
11
143
0.77
0.32
1.2
1.4
6.38
6.30
mmol/l
0.04
11
135
15
119
1.26
0.32
1.1
1.2
1.28
1.52
nmol/l
0.79
15
109
7
53
1.32
0.31
2.9
3.2
743.43
1332.62
u/ml
—
7
53
22
260
0.84
0.29
1.8
1.7
—
—
—
0
0
77
709
1.09
0.28
1.4
1.5
—
—
—
0
0
29
251
1.16
0.28
3.8
3.7
75.43
1260.10
u/ml
0.65
24
236
13
103
1.26
0.28
1.8
1.3
—
—
—
0
0
10
76
1.32
0.28
1.0
1.9
16.99
19.82
nmol/l
—
10
68
9
117
0.77
0.27
1.2
1.4
—
—
—
0
0
23
196
1.18
0.27
1.3
1.4
122.33
158.09
au/ml
—
6
57
25
215
1.17
0.26
1.2
1.2
—
—
—
0
0
8
66
1.21
0.26
1.1
1.2
25.63
33.65
mmol/l
—
8
60
8
67
1.20
0.26
3.3
2.6
—
—
—
0
0
293
3029
0.96
0.26
3.2
3.3
0.71
0.78
ug/l
1.04
192
1985
126
1192
1.06
0.25
2.5
2.4
12.52
13.49
nmol/l
0.74
112
1070
46
417
1.11
0.24
3.3
3.7
1.34
1.42
mmol/l
0.31
46
412
31
275
1.13
0.23
1.4
1.4
10.82
7.71
u/l
0.52
25
223
5
40
1.25
0.22
2.4
1.8
46.80
57.93
ug/l
—
5
40
27
305
0.88
0.22
1.1
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
177.80
—
0
5
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
52
479
1.09
0.21
1.1
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
5.2
—
14.92
—
0
13
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
10
123
0.81
0.20
1.0
1.2
—
—
—
0
0
360
3683
0.97
0.19
3.3
3.3
—
—
—
0
0
77
725
1.07
0.19
1.2
1.2
—
—
—
0
0
109
1038
1.05
0.19
3.2
3.3
4.52
4.49
kpa
0.06
104
1010
16
137
1.17
0.19
1.7
2.3
0.57
0.45
mmol/l
0.04
16
132
10
81
1.24
0.18
1.0
1.1
108.40
101.95
pmol/l
—
10
81
15
128
1.17
0.18
1.9
2.4
—
—
—
0
0
20
176
1.14
0.17
1.2
1.3
—
—
—
0
0
24
215
1.12
0.16
1.3
1.4
—
—
—
0
0
289
2823
1.03
0.16
3.3
2.9
0.00
0.08
—
8
64
8
72
1.11
0.16
1.4
1.8
—
—
—
0
0
10
83
1.21
0.15
3.6
2.9
34.40
39.65
%
—
5
44
31
286
1.09
0.13
1.4
1.5
34.34
26.94
iu/l
0.55
24
245
13
148
0.88
0.12
1.2
1.5
—
—
—
0
0
11
127
0.86
0.12
3.3
2.5
—
—
—
0
0
24
220
1.09
0.12
1.3
1.3
296.00
230.41
miu/ml
—
7
92
26
281
0.92
0.11
1.2
1.2
—
—
—
0
0
21
192
1.10
0.11
1.1
1.1
—
—
—
0
0
19
173
1.10
0.10
1.1
1.1
9.00
69.31
iu/ml
—
5
33
22
238
0.92
0.09
2.7
1.9
4.49
4.81
iu/l
—
10
88
40
422
0.95
0.09
1.4
1.9
11.25
7.12
iu/ml
—
10
105
25
233
1.07
0.09
1.4
1.4
22.20
46.57
e6/l
0.40
20
173
14
126
1.11
0.09
1.1
1.1
—
—
—
0
0
6
57
1.05
0.08
1.3
1.2
—
—
—
0
0
6
57
1.05
0.08
1.8
1.4
16.70
7.82
ug/l
—
6
50
8
78
1.03
0.07
1.4
1.3
—
—
—
0
0
7
84
0.83
0.07
2.1
2.5
8.26
8.14
mmol/l
—
7
84
9
87
1.03
0.07
1.1
1.1
—
—
titre
—
0
0
58
596
0.97
0.05
1.5
1.6
—
—
—
0
0
14
130
1.08
0.04
2.6
2.8
10.86
10.48
%
0.12
14
130
47
459
1.02
0.03
2.4
3.6
90.83
8869.87
u/ml
0.84
41
393
11
102
1.08
0.03
1.5
1.9
—
—
—
0
0
53
519
1.02
0.03
1.8
2.1
0.00
1.66
estimate
0.51
12
153
22
229
0.96
0.03
3.9
3.4
7.36
7.55
mmol/l
0.15
22
222
22
228
0.96
0.02
1.4
1.4
3.82
3.77
mmol/l
0.09
22
215
10
107
0.93
0.02
1.5
1.6
—
—
—
0
0
284
2850
1.00
0.01
1.4
1.4
—
—
—
0
0
422
4212
1.00
0.00
2.1
2.0
1.43
1.38
mmol/l
0.51
349
3523
19
184
1.03
0.00
1.1
1.1
—
—
—
0
0
18
176
1.02
0.00
1.7
1.6
0.71
0.77
g/l
0.16
12
141
21
212
0.99
0.00
1.4
1.4
—
—
—
0
0
21
211
1.00
0.00
4.6
3.9
9.30
9.72
pmol/l
0.06
21
211
104
1038
1.00
0.00
1.6
1.5
—
—
—
0
0
30
301
1.00
0.00
1.1
1.1
—
—
—
0
0
30
299
1.00
0.00
1.7
1.5
11033.53
12436.93
e6/l
0.10
19
213
14
135
1.04
0.00
1.2
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
6
65
0.92
0.00
1.2
1.6
4.12
7.41
u/l
—
6
52
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
3.70
—
0
5
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
3.68
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
78.20
—
0
5
41
410
1.00
-0.00
2.7
3.8
3596.87
443.46
mg/l
0.47
23
179
8
79
1.01
-0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
320.39
—
0
7
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
95
0.95
-0.00
1.0
1.2
—
—
—
0
0
7
79
0.89
-0.00
5.4
2.7
16.10
16.43
%
—
7
79
0
5
0.00
-0.00
0.0
1.2
—
182.20
—
0
5
0
6
0.00
-0.00
0.0
2.2
—
362.33
—
0
6
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
60.00
—
0
5
0
8
0.00
-0.00
0.0
1.0
—
0.06
—
0
8
8
83
0.96
-0.00
1.8
1.6
400.38
317.24
mu/l
—
8
63
0
6
0.00
-0.00
0.0
5.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
391.60
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_LARYNX and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_LARYNX 1.44 [1.24, 1.67] < 0.001
Birth year 0.999 [0.99, 1.01] 0.792

During the follow-up period (1.1.1998 — 31.12.2019), 365 out of 1646 females with CD2_BENIGN_LARYNX died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_LARYNX 1.766 [1.57, 1.99] < 0.001
Birth year 0.985 [0.97, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 973 out of 3146 males with CD2_BENIGN_LARYNX died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_LARYNX.

N-year risk Females Males
1 0.172% 0.328%
5 1.02% 1.903%
10 2.305% 4.549%
15 4.399% 8.697%
20 7.596% 14.442%

Relationships between endpoints

Index endpoint: CD2_BENIGN_LARYNX – Benign neoplasm: Larynx

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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