Vaginal neoplasm: Tumors or cancer of the VAGINA.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
141 |
4. Check minimum number of eventsNone |
141 |
5. Include endpointsNone |
141 |
6. Filter based on genotype QC (FinnGen only) |
116 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D15
- Name in latin
- Neoplasma benignum cordis
Similar endpoints
↥List of similar endpoints to
Benign neoplasm: Heart
based on the number of shared cases.
Similar with more cases:
- Benign neoplasm of other and unspecified intrathoracic organs
- Benign neoplasms
- Neoplasms
- Any operation in hilmo
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 719 | 436 | 281 |
| Only index persons | 621 | 389 | 232 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 61.80 | 64.15 | 58.30 |
| Only index persons | 63.25 | 64.79 | 60.65 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 116 | 68 | 48 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 63.01 | 62.51 | 63.70 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 125
- Matched controls
- 1250
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D15.1
ICD-10 Finland
Benign neoplasm: Heart
+∞
174.6
123
*
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
32.8
83.2
65
40
FFA10
NOMESCO Finland
Excision of lesion of atrium
+∞
82.7
70
*
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
44.7
78.4
51
19
WX872
NOMESCO Finland
Intensive care
18.5
43.9
40
31
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
6.9
25.7
59
143
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
6.3
24.0
69
204
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
5.7
20.5
57
160
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
5.0
18.1
68
241
B01AA03
ATC
warfarin; systemic
5.2
17.6
52
151
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
7.8
16.1
25
39
D48.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other specified sites
91.1
14.9
16
*
AJX
HP
Other surgery on the heart or aorta
143.8
12.7
13
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.3
12.3
92
495
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
4.0
11.5
43
144
AMX
HP
Other surgical procedure for a demanding cardiac patient
+∞
10.6
10
*
C07AB07
ATC
bisoprolol; oral
3.6
9.9
88
501
C03CA01
ATC
furosemide; systemic
3.1
9.1
62
298
B01AF02
ATC
apixaban; oral
3.7
8.6
33
111
I48
ICD-10 Finland
Atrial fibrillation and flutter
3.2
8.5
47
199
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
4.9
8.3
20
47
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
4.2
8.2
25
71
B01AB05
ATC
enoxaparin; parenteral
2.9
7.7
60
304
207
Kela drug reimbursment
Chronic arrhythmias
3.3
7.7
36
137
51
HP
Other heart surgery
+∞
7.4
7
*
R06.0
ICD-10 Finland
Dyspnoea
2.9
7.3
51
242
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
3.3
7.3
34
128
TFP20
NOMESCO Finland
Cardiodefibrillation
4.2
7.3
21
57
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
4.1
7.2
22
62
XF404
NOMESCO Finland
Ambulatory ECG
4.0
7.1
22
63
I48.4
ICD-10 Finland
Atypical atrial flutter
42.4
6.8
8
*
AN1
HP
Coronary angiography
3.6
6.8
26
86
WX408
NOMESCO Finland
General anesthesy, balanced
2.8
6.7
47
223
D15.9
ICD-10 Finland
Benign neoplasm: Intrathoracic organ, unspecified
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
75
388
3.33
9.90
4.0
3.4
1063.73
1442.75
ng/l
0.70
70
329
56
272
2.92
7.80
2.3
2.4
—
—
—
0
0
39
155
3.20
7.72
13.7
7.7
1.27
1.27
mmol/l
0.00
33
126
86
527
3.03
7.72
2.9
2.7
—
—
estimate
—
0
0
39
159
3.11
7.36
14.0
7.5
5.32
5.14
kpa
0.39
39
152
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
17
29
6.61
6.90
5.2
2.6
0.36
0.46
iu/ml
—
10
12
24
81
3.43
6.08
15.6
10.8
96.12
94.07
%
2.16
24
81
38
183
2.55
5.06
12.6
7.0
106.58
104.25
mmol/l
2.93
38
183
55
323
2.25
4.63
3.8
2.1
2.97
2.92
mg/l
0.06
49
283
84
615
2.12
3.74
11.3
7.8
1.18
1.21
mmol/l
2.74
73
536
77
564
1.95
3.22
13.8
6.8
1.18
1.21
mmol/l
3.55
72
517
31
165
2.17
3.18
2.9
1.8
—
—
—
0
0
12
37
3.48
3.03
6.6
2.9
89.17
100.19
%
1.01
12
37
40
241
1.97
2.93
3.1
1.9
1.55
1.15
mg/l
0.26
34
205
66
470
1.86
2.90
6.8
4.2
70.09
30.84
ng/l
1.35
50
354
16
66
2.63
2.84
2.6
1.3
—
—
—
0
0
84
649
1.90
2.82
12.1
10.8
4.19
4.11
e9/l
0.14
70
559
36
219
1.90
2.53
3.2
2.0
—
—
—
0
0
28
156
2.02
2.52
3.1
1.9
—
—
—
0
0
101
844
2.02
2.50
5.3
4.5
19.96
12.69
mm/h
2.39
96
776
5
10
5.16
2.09
1.6
1.3
—
—
—
0
0
77
616
1.65
1.95
3.0
2.9
—
—
—
0
0
17
88
2.08
1.85
2.5
3.4
76.17
57.95
ml/min/173m2
—
6
37
9
36
2.61
1.78
2.2
1.3
—
—
—
0
0
29
188
1.71
1.62
1.2
1.3
14.62
8.81
u/ml
—
8
58
12
57
2.22
1.61
1.5
1.9
8.23
7.17
g/l
0.88
12
52
12
57
2.22
1.61
1.5
1.9
4.43
4.41
g/l
0.03
12
52
12
57
2.22
1.61
1.5
1.9
3.98
3.48
g/l
0.44
12
52
7
26
2.79
1.60
1.6
1.8
—
—
—
0
0
6
20
3.10
1.60
1.0
1.5
—
—
—
0
0
6
20
3.10
1.60
1.0
1.5
—
—
—
0
0
8
33
2.52
1.56
1.5
1.5
—
—
—
0
0
111
1007
1.91
1.48
5.8
5.5
1.90
1.99
mu/l
0.42
103
915
65
522
1.51
1.46
2.3
2.1
97.17
96.89
pmol/l
0.02
44
257
77
642
1.52
1.44
8.4
6.8
10.22
11.36
umol/l
0.92
72
609
11
53
2.18
1.43
1.5
1.9
12.34
9.62
g/l
0.61
11
47
113
1036
1.95
1.38
5.5
5.4
6.02
5.99
mmol/l
0.09
104
948
55
433
1.48
1.33
4.6
3.4
—
—
—
0
0
6
24
2.57
1.32
1.0
1.2
1.52
1.62
g/l
—
6
24
6
24
2.57
1.32
1.7
1.7
—
—
—
0
0
51
396
1.49
1.32
4.2
3.5
2.36
2.36
mmol/l
0.05
44
364
5
18
2.85
1.29
1.2
1.2
—
—
—
0
0
8
36
2.30
1.27
1.5
1.6
—
—
—
0
0
6
25
2.47
1.26
1.0
1.2
0.80
0.93
g/l
—
6
25
111
1020
1.79
1.23
6.8
6.9
38.93
40.07
mmol/mol
0.81
102
950
45
346
1.47
1.20
4.5
3.2
0.65
0.55
e6/l
0.11
32
241
6
26
2.37
1.20
1.3
1.6
—
—
—
0
0
96
855
1.53
1.18
3.7
4.4
15.00
14.88
pmol/l
0.21
87
774
12
65
1.94
1.18
6.5
2.5
0.69
0.64
%
0.32
12
65
30
213
1.54
1.16
3.7
2.9
1.80
1.31
e6/l
0.29
16
109
22
147
1.60
1.10
2.3
4.4
3.26
36.05
ug/l
0.63
16
126
5
21
2.44
1.10
3.6
1.6
—
—
—
0
0
12
67
1.88
1.09
6.5
2.5
1.15
1.26
%
0.17
12
67
10
53
1.96
1.04
1.6
2.0
3.00
2.89
g/l
—
10
48
18
116
1.64
1.03
4.7
3.8
—
—
—
0
0
28
203
1.49
0.99
3.8
3.0
2.38
2.82
e6/l
0.16
14
99
7
36
2.00
0.98
1.4
2.0
—
—
—
0
0
7
36
2.00
0.98
2.4
1.4
—
2.19
—
0
10
7
37
1.94
0.95
1.3
1.3
—
—
—
0
0
6
27
2.28
0.95
1.5
1.1
—
—
—
0
0
31
233
1.44
0.92
3.1
2.7
2.50
2.46
mmol/l
0.63
25
209
6
30
2.05
0.88
2.2
1.8
—
—
—
0
0
29
217
1.44
0.88
1.2
1.2
148.84
35.51
iu/ml
—
5
78
14
89
1.65
0.85
1.4
1.4
—
—
—
0
0
0
27
0.00
0.78
0.0
1.1
—
12.33
—
0
6
5
24
2.13
0.75
7.4
2.0
10.40
10.79
mmol/l
—
5
24
7
40
1.79
0.72
2.9
1.7
—
—
—
0
0
7
42
1.71
0.69
2.7
1.7
—
—
—
0
0
5
27
1.89
0.69
3.6
1.7
—
—
—
0
0
5
28
1.82
0.67
2.4
1.8
—
—
—
0
0
29
230
1.34
0.63
1.5
1.9
380.07
491.68
pmol/l
1.95
21
191
13
89
1.51
0.61
1.5
1.4
—
—
—
0
0
114
1090
1.52
0.60
38.7
20.7
139.66
139.72
mmol/l
0.12
114
1075
10
65
1.59
0.57
13.6
4.1
43.00
45.25
%
—
10
65
114
1093
1.49
0.55
38.6
20.8
3.99
3.97
mmol/l
0.26
114
1076
116
1118
1.52
0.55
37.3
22.7
76.24
78.12
umol/l
0.36
116
1110
68
613
1.24
0.53
5.4
4.1
0.00
0.00
estimate
-0.00
14
119
105
999
1.32
0.48
4.6
4.4
1.19
1.27
mmol/l
1.17
97
903
16
123
1.34
0.43
7.0
8.4
—
—
—
0
0
5
32
1.59
0.42
1.0
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.4
—
—
—
0
0
43
378
1.21
0.41
2.9
2.4
50.53
67.42
u/l
0.73
36
345
5
35
1.45
0.40
1.8
1.5
1.16
1.09
g/l
—
5
35
5
35
1.45
0.40
1.0
1.2
—
—
—
0
0
5
35
1.45
0.40
1.6
1.4
0.27
0.23
g/l
—
5
35
5
36
1.40
0.38
1.0
1.2
—
—
—
0
0
66
608
1.18
0.37
5.5
4.1
0.00
12.21
estimate
0.50
15
133
32
367
0.83
0.36
6.4
4.0
0.00
0.00
estimate
-0.00
15
113
110
1065
1.27
0.32
6.7
6.2
2.54
2.65
mmol/l
0.58
104
972
65
604
1.16
0.31
5.4
4.0
0.00
0.00
estimate
-0.00
15
125
11
84
1.34
0.31
2.5
1.7
—
—
—
0
0
55
508
1.15
0.28
3.1
2.5
71.45
77.78
nmol/l
0.99
46
454
13
159
0.80
0.26
1.5
1.5
—
—
—
0
0
5
37
1.37
0.24
1.2
1.5
—
—
—
0
0
5
37
1.37
0.24
4.2
1.9
—
—
—
0
0
117
1150
1.27
0.22
43.9
26.0
4.33
4.45
e12/l
2.10
117
1122
117
1150
1.27
0.22
46.5
26.5
38.60
39.98
%
2.90
117
1138
117
1150
1.27
0.22
43.9
26.0
90.98
91.31
fl
0.33
117
1140
117
1150
1.27
0.22
44.6
26.2
127.08
133.72
g/l
5.11
117
1138
117
1150
1.27
0.22
44.0
26.0
254.57
249.16
e9/l
0.33
117
1129
0
10
0.00
0.21
0.0
3.8
—
0.90
—
0
10
0
10
0.00
0.21
0.0
5.3
—
1013.20
—
0
10
108
1053
1.19
0.21
5.7
5.3
4.37
4.59
mmol/l
1.28
103
970
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
43
398
1.12
0.20
4.1
4.1
13.52
11.30
mg/mmol
0.08
30
248
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
7
61
1.16
0.18
1.0
2.0
—
—
—
0
0
50
471
1.10
0.17
2.2
1.9
1.34
1.32
mmol/l
0.10
42
380
107
1047
1.15
0.16
5.7
5.2
1.40
1.49
mmol/l
1.68
102
951
25
271
0.90
0.13
4.5
4.7
29.80
22.42
%
1.23
11
137
47
450
1.07
0.10
5.5
4.1
0.00
0.00
estimate
-0.00
12
102
5
45
1.12
0.10
1.0
2.1
—
—
—
0
0
5
46
1.09
0.09
1.0
1.8
—
—
—
0
0
5
46
1.09
0.09
1.6
2.7
—
—
—
0
0
31
294
1.07
0.08
1.7
1.4
1.44
1.84
u/ml
—
9
65
34
324
1.07
0.08
5.1
3.5
0.00
0.00
estimate
-0.00
13
102
15
161
0.92
0.05
1.5
1.5
—
—
—
0
0
21
203
1.04
0.01
3.3
3.2
1.98
0.74
ug/l
0.77
15
139
15
144
1.05
0.00
5.6
4.7
36.22
32.32
%
—
9
85
27
273
0.99
0.00
5.6
4.1
1.01
1.02
kg/l
1.34
20
188
34
345
0.98
0.00
5.4
5.7
2.45
2.04
ug/l
0.15
28
302
11
105
1.05
0.00
2.5
2.8
0.46
1.05
e6/l
0.29
11
100
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
66.04
—
0
8
0
8
0.00
0.00
0.0
1.3
—
66.19
—
0
8
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
88.00
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
48.17
—
0
6
5
54
0.92
-0.00
1.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
971.33
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
1720.17
—
0
6
0
5
0.00
-0.00
0.0
1.6
—
6.92
—
0
5
6
68
0.88
-0.00
1.0
2.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.9
—
63.00
—
0
9
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_HEART and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_HEART | 1.784 [1.25, 2.54] | 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.247 |
During the follow-up period (1.1.1998 — 31.12.2019), 79 out of 322 females with CD2_BENIGN_HEART died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_HEART.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.171% | No data |
| 5 | 1.002% | No data |
| 10 | 2.657% | No data |
| 15 | 5.205% | No data |
| 20 | 9.086% | No data |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_HEART – Benign neoplasm: Heart
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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