Mesothelioma, including Hilmo

C3_MESOTHELIOMA_WIDE

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C45
  • Hospital discharge: ICD-9 158|163
  • Hospital discharge: ICD-8 158|163
  • Cause of death: ICD-10 C45
  • Cause of death: ICD-9 158|163
  • Cause of death: ICD-8 158|163
  • Cancer registry: Topography ICD-O-3 ANY
  • Cancer registry: Morphology ICD-O-3 905[0-3]
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

524

4. Check minimum number of events

None

524

5. Include endpoints

None

524

6. Filter based on genotype QC (FinnGen only)

475

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

First used in FinnGen datafreeze
DF12
Parent code in ICD-10
C45-C49
Name in latin
Mesothelioma

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 475 128 347
Unadjusted period prevalence (%) 0.13 0.05 0.16
Median age at first event (years) 70.99 66.73 72.57

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
491
Matched controls
4910
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
130
Kela drug reimbursment
Malignant tumour
+∞
321.4
272
*
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
69.7
307.7
260
78
C45.0
ICD-10 Finland
Mesothelioma of pleura
+∞
307.7
362
*
H02AB02
ATC
dexamethasone; systemic
193.6
307.7
217
20
A03FA01
ATC
metoclopramide; systemic, rectal
20.1
253.2
261
263
A04AA01
ATC
ondansetron; systemic, rectal
53.6
239.7
142
37
Z51.5
ICD-10 Finland
Palliative care
23.4
229.1
192
131
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
43.7
181.6
112
33
J94.8
ICD-10 Finland
Other specified pleural conditions
37.7
179.6
116
40
N02AA05
ATC
oxycodone; systemic
11.9
175.8
282
499
9050/3-C38.4
ICD-O-3
Mesothelioma, malignant of pleura, NOS
+∞
168.8
152
*
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
21.8
158.4
128
78
TGA30
NOMESCO Finland
Thoracocentesis
79.0
137.4
74
11
9052/3-C38.4
ICD-O-3
Epithelioid mesothelioma, malignant of pleura, NOS
+∞
132.4
121
*
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
25.7
122.1
89
42
GAC01
NOMESCO Finland
Endoscopic biopsy of pleura
743.9
121.8
115
*
JN4BD
NOMESCO Finland
Extensive body CT
13.4
113.4
120
116
WX302
NOMESCO Finland
Thoracal epidural anesthesy
22.9
100.2
76
39
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
34.0
92.3
60
20
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
979.4
86.4
82
*
GA4AT
NOMESCO Finland
Cathetrisation of pleural cavity with ultrasound guidance
49.4
83.4
49
11
C45.9
ICD-10 Finland
Mesothelioma, unspecified
+∞
78.3
73
*
JN4AD
NOMESCO Finland
Body CT examination
7.9
69.6
109
171
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
9.8
68.5
87
106
C45.1
ICD-10 Finland
Mesothelioma of peritoneum
+∞
67.3
63
*
A04AA02
ATC
granisetron; systemic, transdermal
731.5
66.6
64
*
GAC00
NOMESCO Finland
Biopsy of pleura
190.1
64.7
66
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
6.2
63.4
132
276
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
14.4
63.4
60
47
L01CA04
ATC
vinorelbine; systemic
+∞
58.5
55
*
GD1AD
NOMESCO Finland
Thorax CT examination
7.5
57.2
91
144
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
316.2
56.5
56
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
6.6
55.9
103
190
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
52.0
49
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
552.5
51.4
50
*
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
48.8
46
*
N02AA01
ATC
morphine; systemic, rectal
14.1
47.5
45
35
C61
ICD-10 Finland
Malignant neoplasm of prostate
503.4
47.1
46
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
45.5
43
*
1BA04, ,
NOMESCO Finland
+∞
42.3
40
*
9051/3-C38.4
ICD-O-3
Fibrous mesothelioma, malignant of pleura, NOS
+∞
39.1
37
*
J94.9
ICD-10 Finland
Pleural condition, unspecified
61.7
39.0
45
8
ZX120
NOMESCO Finland
Intravenous
5.8
38.6
78
155
D38.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pleura
+∞
38.0
36
*
GD1BA
NOMESCO Finland
Extensive X-ray examination of thorax
16.0
37.7
33
22
J92.0
ICD-10 Finland
Pleural plaque with presence of asbestos
7.4
36.0
55
82
B03BA03
ATC
hydroxocobalamin; parenteral
5.1
35.9
85
194
GAA96
NOMESCO Finland
Other open or percutaneous drainage of pleural cavity
129.2
34.2
36
*
C38.4
ICD-10 Finland
Malignant neoplasm: Pleura
+∞
32.7
31
*
R84
ICPC
Malignant neoplasm bronchus/lung
345.0
32.3
32
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
121.5
32.1
34
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.1
31.6
319
1837
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
6.4
31.3
55
95
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
30.5
29
*
WZC00
NOMESCO Finland
Treatment plan or consultation
3.1
29.8
176
749
XX3DW
NOMESCO Finland
Time consuming IT work
6.4
29.8
52
89
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.2
29.5
162
661
A06AH03
ATC
naloxegol; oral
43.1
29.4
36
9
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
309.4
29.1
29
*
GD1AT
NOMESCO Finland
Biopsy of the lung with ultrasound guidance
+∞
28.4
27
*
J01MA14
ATC
moxifloxacin; systemic
4.1
27.9
86
240
WX600
NOMESCO Finland
Single shot through catheter
56.9
27.5
32
6
L03AA13
ATC
pegfilgrastim; parenteral
148.1
26.9
28
*
116
Kela drug reimbursment
Prostate cancer
+∞
25.2
24
*
A79
ICPC
Malignancy NOS
+∞
25.2
24
*
WZC30
NOMESCO Finland
Teaching
3.5
25.0
101
338
J01MA12
ATC
levofloxacin; systemic
3.0
24.4
142
591
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
251.8
23.9
24
*
YG1AD
NOMESCO Finland
CT examination of thorax for dose design of radiotherapy
+∞
23.1
22
*
L03AA02
ATC
filgrastim; parenteral
240.8
22.8
23
*
GAA31
NOMESCO Finland
Thoracoscopy
120.4
21.8
23
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.5
21.6
56
136
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.2
21.6
103
380
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
8.7
21.6
28
34
GD5AD
NOMESCO Finland
Thorax and upper abdomen combined CT examination of
18.9
21.2
32
18
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
50.3
20.3
24
5
TK800
NOMESCO Finland
Hemodialysis
7.4
20.1
30
43
WW500
NOMESCO Finland
Blood transfusion
7.4
20.1
30
43
9053/3-C38.4
ICD-O-3
Mesothelioma, biphasic, malignant of pleura, NOS
+∞
19.9
19
*
A04AD12
ATC
aprepitant; systemic
+∞
18.9
18
*
R85
ICPC
Malignant neopl respiratory other
+∞
17.8
17
*
C45
ICD-10 Finland
Mesothelioma
+∞
17.8
17
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.6
17.7
136
641
JN4CD
NOMESCO Finland
Very extensive body CT
13.2
17.4
30
24
GA2AT
NOMESCO Finland
Pleural biopsy with ultrasound guidance
+∞
16.8
16
*
R18
ICD-10 Finland
Ascites
7.3
16.7
25
36
R82
ICPC
Pleurisy/pleural effusion
93.3
16.7
18
*
L02AE02
ATC
leuprorelin; implant, parenteral
93.3
16.7
18
*
QBC00
NOMESCO Finland
Removal of foreign body from skin of trunk or subcutaneous tissue
175.7
16.6
17
*
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
62.1
15.9
18
*
GDD20
NOMESCO Finland
Extended pneumonectomy
+∞
15.7
15
*
C45.7
ICD-10 Finland
Mesothelioma of other sites
+∞
15.7
15
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
15.7
15
*
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.4
14.9
57
182
GAC30
NOMESCO Finland
Artificial pneumothorax
+∞
14.7
14
*
WW200, ,
SPAT
0.3
14.4
33
1073
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
43.9
14.2
17
*
JAL30
NOMESCO Finland
Omentectomy
31.1
14.0
18
6
WF002
NOMESCO Finland
Radical radiotherapy
55.0
13.9
16
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.3
13.7
132
679
H02AB06
ATC
prednisolone; systemic
2.1
13.7
253
1673
GAC97
NOMESCO Finland
Other endoscopic operation on pleura
77.3
13.6
15
*
C78.6
ICD-10 Finland
Secondary malignant neoplasm of retroperitoneum and peritoneum
+∞
13.6
13
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
13.6
13
*
GAC43
NOMESCO Finland
Total decortication of pleura
143.8
13.5
14
*
WD325
NOMESCO Finland
Demanding therapy of methastized malignancy with biomodifiers
143.8
13.5
14
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.8
13.5
77
310
GDA11
NOMESCO Finland
Thoracoscopic biopsy of lung
29.3
13.0
17
6
B01AB10
ATC
tinzaparin; parenteral
3.1
12.8
57
200
Z2446
NOMESCO Finland
Social worker
3.6
12.6
44
132
9050/3-C48.2
ICD-O-3
Mesothelioma, malignant of peritoneum, NOS
+∞
12.6
12
*
ZX080
NOMESCO Finland
Image guided radiotherapy
+∞
12.6
12
*
C78.2
ICD-10 Finland
Secondary malignant neoplasm of pleura
+∞
12.6
12
*
ZXE40
NOMESCO Finland
More than seven and less than nine hours
6.2
12.2
21
35
J86.9
ICD-10 Finland
Pyothorax without fistula
11.5
12.1
22
20
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
4.6
12.1
29
66
N03AX16
ATC
[U] pregabalin
2.2
12.0
120
623
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.0
12.0
194
1209
D70.82
ICD-10 Finland
Drug-induced neutropenia
66.6
11.7
13
*
JAL20
NOMESCO Finland
Excision or destruction of lesion of peritoneum
66.6
11.7
13
*
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
9.0
11.6
24
28
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
+∞
11.5
11
*
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
+∞
11.5
11
*
GDD96
NOMESCO Finland
Other pneumonectomy
+∞
11.5
11
*
J18.0
ICD-10 Finland
Bronchopneumonia, unspecified
5.6
11.4
22
41
R4110
NOMESCO Finland
Physiotherapy
2.1
11.4
141
794
SPAT1109
SPAT
Analgesia with portable analgesic pump
35.9
11.3
14
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
44.4
11.0
13
*
XX1XW
NOMESCO Finland
Extensive written report from radiologist
5.6
11.0
21
39
N06DX01
ATC
memantine; oral
0.1
10.7
7
435
G30.1
ICD-10 Finland
Alzheimer disease with late onset
0.1
10.6
*
341
Y77
ICPC
Malignant neoplasm prostate
112.3
10.5
11
*
NK6AN
NOMESCO Finland
Total body bone isotope imaging
112.3
10.5
11
*
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
+∞
10.5
10
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
10.5
10
*
C34.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of bronchus and lung
+∞
10.5
10
*
AA1BD
NOMESCO Finland
Extensive CT of head and brain
8.5
10.4
22
27
WPA10
NOMESCO Finland
Proactive palliative care treatment plan
33.3
10.4
13
*
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.9
10.3
31
84
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
24.0
10.3
14
6
R06.0
ICD-10 Finland
Dyspnoea
1.9
10.0
169
1056
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
7.8
9.5
21
28
ZXE10
NOMESCO Finland
More than one and less than three hours
1.9
9.5
174
1113
GAC37
NOMESCO Finland
Endoscopic chemical pleurodesis
101.9
9.4
10
*
L03AA14
ATC
lipegfilgrastim; parenteral
+∞
9.4
9
*
GD2FN
NOMESCO Finland
Lung ventilation distribution isotope examination (radiospirometry)
+∞
9.4
9
*
GA2CT
NOMESCO Finland
Pleural biopsy with CT guidance
+∞
9.4
9
*
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
+∞
9.4
9
*
KEC00
NOMESCO Finland
Retropubic radical prostatectomy
+∞
9.4
9
*
WD315
NOMESCO Finland
Multiple therapy of methastized malignancy with biomodifiers
+∞
9.4
9
*
A04AA03
ATC
tropisetron; systemic
+∞
9.4
9
*
C34.90
ICD-10 Finland
Malignant tumor in unspecified location in bronchus and lung without histology
+∞
9.4
9
*
L02BB03
ATC
bicalutamide; oral
+∞
9.4
9
*
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
9.4
185
1209
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
3.1
9.4
41
142
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
8.2
8.9
19
24
XW4AT
NOMESCO Finland
Biopsy of other inner organ with ultrasound guidance
50.9
8.7
10
*
N05CF01
ATC
zopiclone; oral
1.8
8.6
173
1131
J93.9
ICD-10 Finland
Pneumothorax, unspecified
20.4
8.5
12
6
KE1AT
NOMESCO Finland
Biopsy of prostata with ultrasoudnguidance
3.7
8.4
27
77
1638X
ICD-9 Finland
Malignant neoplasm of pleura, Other specified sites of pleura
+∞
8.4
8
*
KE3AT
NOMESCO Finland
Transrectal gold marker implantation in prostate under ultrasound guidance
+∞
8.4
8
*
166
Kela drug reimbursment
Dalteparin and tinzaparin (treatment for more than 6 months)
+∞
8.4
8
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
8.4
8
*
1580A
ICD-9 Finland
Malignant neoplasm of retroperitoneum and peritoneum, Retroperitoneum
+∞
8.4
8
*
C34.99
ICD-10 Finland
Malignant tumor in unspecified localization in bronchial and pulmonary other or unspecified histology
+∞
8.4
8
*
C34.10
ICD-10 Finland
Malignant tumor of the upper lobe, bronchus or lung without histology
+∞
8.4
8
*
9052/3-C48.2
ICD-O-3
Epithelioid mesothelioma, malignant of peritoneum, NOS
+∞
8.4
8
*
N02AX02
ATC
tramadol; systemic, rectal
1.8
8.3
213
1491
B01AB05
ATC
enoxaparin; parenteral
1.8
8.1
150
954
Z57.2
ICD-10 Finland
Occupational exposure to dust
9.1
8.1
16
18
Z2221
NOMESCO Finland
Medical doctor
1.9
8.0
123
736
JAH01
NOMESCO Finland
Laparoscopy
4.6
8.0
19
43
308
Kela drug reimbursment
Alprostadil, sildenafil and combination product containing aviptadil and phentolamine
45.7
7.7
9
*
QX3AT
NOMESCO Finland
Ultrasound guided biopsy of subcutaneous tissue
45.7
7.7
9
*
GAC46
NOMESCO Finland
Partial decortication of pleura
45.7
7.7
9
*
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
3.8
7.7
23
62
GA3AT
NOMESCO Finland
Pleural cytology with ultrasound guidance
18.7
7.6
11
6
GAB10
NOMESCO Finland
Antero- or postero-lateral thoracotomy
18.7
7.6
11
6
R4190
NOMESCO Finland
Nutritional therapy
4.5
7.5
18
41
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
81.3
7.4
8
*
WPA16, ,
SPAT
81.3
7.4
8
*
P20
ICPC
Memory disturbance
0.4
7.4
30
756
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.1
7.4
72
367
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
+∞
7.3
7
*
WPA43, ,
SPAT
+∞
7.3
7
*
8140/3-C34.9
ICD-O-3
Adenocarcinoma, NOS, of lung, NOS
+∞
7.3
7
*
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
7.3
7
*
1990X
ICD-9 Finland
Malignant neoplasm without specification of site, Disseminated
+∞
7.3
7
*
C77.1
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Intrathoracic lymph nodes
+∞
7.3
7
*
115
Kela drug reimbursment
Breast cancer
+∞
7.3
7
*
WX402
NOMESCO Finland
General anaesthesia
2.0
7.2
85
464
JA2AT
NOMESCO Finland
Abdominal puncture with ultrasound guidance
20.4
7.2
10
5
WW200
NOMESCO Finland
Immunization
4.0
7.0
20
52
B01AB04
ATC
dalteparin; parenteral
3.2
7.0
28
92
A02BC02
ATC
pantoprazole; systemic
1.7
6.9
311
2489
SPAT1062
SPAT
Lung clearance therapy
17.0
6.8
10
6
6101
FHL
Exploratory laparotomy, includes possible biopases
17.0
6.8
10
6
TDA90, ,
SPAT
0.1
6.7
*
247
XW3AT
NOMESCO Finland
Biopsy of other superficial organ with ultrasound guidance
22.9
6.7
9
*
J93.8
ICD-10 Finland
Other pneumothorax
12.5
6.6
11
9
N06DA03
ATC
rivastigmine; oral, transdermal
0.1
6.6
*
219
C34.9
ICD-10 Finland
Malignant neoplasm: Bronchus or lung, unspecified
70.7
6.4
7
*
JN5KR
NOMESCO Finland
Very extensive PET-CT of upper body metabolism (eyebrows to thighs)
70.7
6.4
7
*
GAC36
NOMESCO Finland
Chemical pleurodesis
70.7
6.4
7
*
ZX112
NOMESCO Finland
Subcutaneous
11.2
6.3
11
10
OAB73
NOMESCO Finland
Prevention and treatment of malnutrition
11.2
6.3
11
10
8090/3-C44.5
ICD-O-3
Basal cell carcinoma, NOS, of skin of trunk
+∞
6.3
6
*
GDA96
NOMESCO Finland
Other incision, excision of lesion or repair of lung
+∞
6.3
6
*
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
+∞
6.3
6
*
C79.30
ICD-10 Finland
Secondary malignant tumor of the cerebrum
+∞
6.3
6
*
JAL01
NOMESCO Finland
Laparoscopic biopsy of peritoneum
+∞
6.3
6
*
C34.00
ICD-10 Finland
Malignant tumor of the main bronchus without histology
+∞
6.3
6
*
8000/3-C38.4
ICD-O-3
Neoplasm, malignant of pleura, NOS
+∞
6.3
6
*
GAC20
NOMESCO Finland
Excision or destruction of lesion of pleura
+∞
6.3
6
*
128
Kela drug reimbursment
Cancers of female genital organs
+∞
6.3
6
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
0.6
6.3
109
1640
Z3226
NOMESCO Finland
Physiotherapist
1.9
6.2
87
503
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
4.2
6.1
16
39

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
167
43
58.34
284.53
2.5
1.3
—
—
—
0
0
183
69
41.69
280.20
2.0
1.4
40.70
27.54
g/l
11.24
174
61
163
60
40.17
250.23
2.1
1.3
1616.78
2075.29
e6/l
0.39
130
42
154
50
44.42
245.41
2.0
1.3
—
—
—
0
0
154
52
42.69
242.48
2.0
1.3
41092.88
174328.14
e6/l
0.53
108
29
176
91
29.59
238.38
1.8
1.3
—
—
—
0
0
119
52
29.89
169.74
2.0
1.4
—
—
—
0
0
162
208
11.13
126.12
2.3
1.4
2.24
2.85
ug/l
2.39
126
152
72
30
27.95
103.10
1.6
1.4
7.36
7.37
ph
0.14
61
20
202
594
5.08
65.90
2.6
2.0
—
—
—
0
0
181
628
3.98
44.95
5.5
2.5
0.78
0.83
mmol/l
7.43
171
582
222
1019
3.15
33.66
2.9
1.7
—
—
—
0
0
240
1216
2.90
29.52
7.2
5.0
—
—
—
0
0
29
26
11.79
27.80
1.9
1.8
41.59
23.59
ng/l
0.39
29
26
243
1273
2.80
27.55
5.9
4.2
—
—
—
0
0
37
55
7.19
24.12
2.5
2.8
—
—
—
0
0
315
2014
2.57
22.04
17.0
5.7
5.25
4.52
e9/l
1.62
276
1710
304
1930
2.51
21.31
12.3
3.9
9.57
13.13
umol/l
4.99
299
1823
111
432
3.03
21.19
1.5
1.4
—
—
—
0
0
277
1716
2.41
20.06
8.2
5.3
20.38
25.35
%
11.85
272
1611
274
1692
2.40
19.95
8.3
5.3
9.55
9.14
%
1.51
268
1569
176
924
2.41
18.15
8.3
3.9
84.95
80.20
%
2.23
169
910
80
286
3.15
17.50
1.2
1.1
—
—
—
0
0
276
1778
2.26
17.31
7.7
4.0
30.60
35.06
g/l
22.06
270
1645
285
1875
2.24
16.78
7.9
5.1
0.74
0.62
e9/l
8.10
243
1567
265
3544
0.45
16.30
6.5
7.7
40.80
40.62
mmol/mol
0.11
235
3274
284
1882
2.21
16.21
7.9
5.1
0.04
0.04
e9/l
0.42
244
1578
285
1900
2.19
15.91
8.1
5.2
1.57
1.76
e9/l
3.47
248
1628
66
1541
0.34
15.76
1.7
1.9
1.41
1.26
mmol/l
0.77
56
1267
285
1941
2.12
14.55
8.3
5.2
0.19
0.21
e9/l
0.60
249
1643
274
1877
2.04
13.32
8.0
5.9
1.20
1.20
mmol/l
0.04
263
1700
296
2110
2.01
12.58
9.4
6.3
1.20
1.20
mmol/l
0.11
262
1809
21
17
12.85
12.22
1.3
1.1
—
—
—
0
0
192
1186
2.02
12.19
3.4
2.2
—
—
—
0
0
296
2124
1.99
12.18
10.1
20.4
1.13
1.40
inr
21.26
246
1791
77
328
2.60
12.00
4.5
4.0
7.42
7.41
ph
1.12
72
270
205
1305
1.98
11.87
6.3
2.1
2.34
2.35
mmol/l
0.25
190
1114
156
904
2.06
11.74
3.3
2.2
—
—
—
0
0
284
3580
0.51
11.61
4.2
5.6
4.29
4.27
mmol/l
0.14
239
3279
280
3545
0.51
11.59
4.2
5.5
1.39
1.39
mmol/l
0.02
237
3215
293
3655
0.51
11.53
4.5
6.6
2.48
2.44
mmol/l
0.33
245
3333
33
89
3.90
11.04
3.0
4.4
—
—
—
0
0
144
836
2.02
10.63
5.9
2.1
2.52
2.44
mmol/l
12.80
131
724
188
1208
1.90
10.24
4.9
3.4
7.41
7.40
ph
2.44
145
861
58
235
2.66
9.95
4.9
4.1
—
—
—
0
0
14
7
20.53
9.85
1.4
1.1
25.61
11.66
g/l
—
14
7
277
3398
0.58
8.03
3.8
4.7
1.22
1.25
mmol/l
0.38
229
3045
281
3422
0.58
7.72
6.3
4.8
2.13
2.01
mu/l
0.42
257
3082
305
3633
0.58
7.65
5.3
5.8
6.18
6.15
mmol/l
0.13
268
3268
99
1591
0.53
7.49
3.1
3.5
24.99
54.36
mg/l
3.55
63
1063
101
1609
0.53
7.40
3.1
3.5
7.74
7.67
mmol/l
0.05
83
1354
127
795
1.81
7.10
1.8
1.6
1.67
1.58
mg/l
0.14
105
634
177
1219
1.71
7.08
4.2
2.3
52.16
61.71
u/l
1.48
168
1127
158
1062
1.72
6.87
12.0
4.3
—
—
—
0
0
105
1627
0.55
6.86
4.2
4.2
6.20
9.38
mg/mmol
0.82
62
1056
167
1144
1.70
6.76
4.3
2.6
32.41
37.64
u/l
0.74
157
1076
146
2056
0.59
6.63
2.1
2.3
94.06
93.89
pmol/l
0.02
92
1113
127
837
1.70
5.81
2.5
2.8
535.48
549.71
mosm/kgh2o
0.33
115
727
223
1694
1.58
5.74
3.8
2.5
—
—
estimate
—
0
0
95
579
1.79
5.71
8.4
6.7
1.77
1.00
mmol/l
1.30
83
476
28
106
2.74
5.50
4.9
3.6
1.95
1.36
index
0.23
19
61
94
582
1.76
5.34
8.6
6.8
7.42
7.41
ph
0.44
50
338
10
11
9.25
5.31
1.2
1.9
—
—
—
0
0
5
0
+∞
5.22
5.4
0.0
41.20
—
u/l
—
5
0
95
1424
0.59
5.13
1.7
1.8
22.89
19.44
nmol/l
1.38
87
1190
16
36
4.56
5.10
1.0
1.2
—
—
—
0
0
120
1694
0.61
5.07
2.4
2.3
77.59
78.06
nmol/l
0.06
104
1465
9
9
10.16
5.04
2.8
1.1
—
—
—
0
0
15
32
4.80
5.03
1.6
1.8
2.58
10295.06
u/l
—
5
9
164
1192
1.56
4.95
2.7
3.1
0.82
0.40
e6/l
1.05
130
863
9
10
9.14
4.80
1.7
1.1
2.34
5.52
nmol/l
—
9
10
8
7
11.59
4.80
1.1
1.0
—
—
—
0
0
54
290
1.97
4.78
1.4
1.5
—
—
—
0
0
76
464
1.75
4.51
1.4
1.3
469.33
553.39
titre
0.23
15
115
70
422
1.77
4.34
10.8
7.7
—
—
—
0
0
230
2773
0.68
4.29
5.2
3.6
15.31
15.06
pmol/l
0.48
212
2475
33
158
2.17
3.98
1.1
1.2
—
—
—
0
0
88
579
1.63
3.95
5.4
5.6
1.05
1.03
mmol/l
0.21
83
522
8
11
7.37
3.87
1.4
3.3
—
—
—
0
0
289
2442
1.45
3.85
8.5
4.9
6.86
6.93
mmol/l
0.29
282
2326
206
1635
1.45
3.85
15.6
10.4
0.01
0.00
e9/l
0.80
155
1320
14
45
3.17
3.67
1.7
1.6
88.77
89.82
%
0.34
14
45
332
2896
1.45
3.62
15.9
5.6
90.93
79.39
u/l
2.83
323
2682
9
17
5.37
3.52
7.1
2.7
0.44
1.06
index
—
9
17
6
6
10.10
3.50
1.2
1.0
0.05
0.03
g/l
—
6
6
63
958
0.61
3.40
5.6
4.4
1.02
1.02
kg/l
1.45
47
630
77
1113
0.63
3.34
3.2
3.9
—
—
—
0
0
25
116
2.22
3.28
1.8
2.5
120.00
132.11
g/l
0.86
18
95
25
119
2.16
3.10
1.4
1.4
1.11
1.12
g/l
0.02
25
114
179
2181
0.72
3.08
5.0
4.6
2.80
2.15
ug/l
1.23
148
1951
169
2078
0.72
3.08
4.5
4.0
0.00
0.02
estimate
0.79
41
399
90
637
1.51
2.93
9.8
6.3
103.78
104.40
mmol/l
0.62
90
637
96
690
1.49
2.90
2.1
2.6
2.12
2.19
g/l
0.49
91
631
170
2075
0.72
2.90
4.4
4.0
36.36
0.00
estimate
0.49
44
429
10
27
3.76
2.89
3.1
4.2
—
—
—
0
0
103
752
1.47
2.88
2.2
2.6
8.72
12.38
umol/l
10.14
98
690
360
3907
0.71
2.84
51.0
25.2
124.46
135.07
g/l
26.54
353
3843
360
3907
0.71
2.84
50.8
25.0
8.33
6.92
e9/l
4.03
348
3794
60
390
1.61
2.84
2.5
2.3
7.58
8.47
umol/l
0.14
55
347
360
3906
0.71
2.82
50.7
25.0
4.28
4.45
e12/l
7.96
347
3789
360
3906
0.71
2.82
50.5
24.9
29.47
30.58
pg
19.92
353
3845
360
3906
0.71
2.82
50.8
25.0
295.02
232.69
e9/l
28.03
347
3810
360
3906
0.71
2.82
51.9
25.5
38.15
40.16
%
11.20
353
3844
360
3905
0.71
2.81
50.6
24.9
90.20
91.94
fl
9.07
353
3844
172
1390
1.37
2.68
3.1
3.2
41.16
137.04
e6/l
1.07
137
1058
168
2033
0.74
2.63
4.5
4.0
0.00
0.00
estimate
-0.00
44
417
359
3884
0.72
2.60
43.1
22.6
82.82
87.48
umol/l
1.52
353
3832
7
195
0.35
2.59
3.1
1.8
—
—
—
0
0
19
375
0.49
2.53
1.7
1.6
—
—
—
0
0
16
69
2.36
2.51
1.4
2.7
—
—
—
0
0
5
8
6.30
2.37
1.6
1.0
74.80
86.50
nmol/l
—
5
8
356
3841
0.73
2.36
38.8
21.5
4.01
4.03
mmol/l
0.39
348
3758
356
3839
0.74
2.33
38.7
21.4
138.42
139.79
mmol/l
13.11
348
3763
71
974
0.68
2.31
4.0
3.9
—
0.00
—
0
13
93
696
1.41
2.27
2.5
3.0
1.81
1.86
e6/l
0.03
51
346
352
3798
0.74
2.26
20.4
10.8
23.84
25.11
u/l
0.92
343
3638
9
30
3.04
2.15
1.6
1.3
—
—
—
0
0
181
1518
1.30
2.10
3.7
3.8
78.65
107.20
e6/l
0.32
142
1085
46
304
1.57
2.07
2.7
4.5
—
—
—
0
0
12
50
2.44
2.04
4.0
2.3
4.11
4.81
e9/l
0.59
12
50
343
3689
0.77
1.92
31.3
15.4
—
—
—
0
0
14
65
2.19
1.89
3.7
2.1
59.65
60.65
%
0.08
14
65
64
463
1.44
1.89
1.7
1.8
—
—
—
0
0
127
1542
0.76
1.88
4.8
4.1
0.00
0.01
estimate
0.50
41
352
8
28
2.89
1.87
2.8
2.8
—
—
—
0
0
138
1650
0.77
1.81
4.1
3.6
6.15
6.28
ph
0.75
79
893
5
135
0.36
1.78
2.6
1.5
—
—
—
0
0
78
1008
0.73
1.77
1.7
1.8
481.36
420.10
pmol/l
0.86
66
822
12
54
2.25
1.75
3.2
2.6
1.68
0.59
mmol/l
0.39
12
54
42
287
1.51
1.66
4.1
3.6
0.84
0.62
%
0.25
22
65
42
288
1.50
1.64
4.3
3.7
—
—
—
0
0
112
910
1.30
1.61
5.3
4.3
71.01
383.97
ng/l
3.99
97
796
16
85
1.91
1.56
1.6
1.5
87.44
57.91
mmol/l
—
9
70
7
27
2.61
1.52
3.0
3.9
7.84
7.38
mmol/l
—
7
15
10
45
2.25
1.47
1.4
1.3
—
—
—
0
0
10
45
2.25
1.47
1.4
1.3
—
—
—
0
0
10
45
2.25
1.47
1.4
1.3
—
—
—
0
0
10
45
2.25
1.47
1.4
1.3
—
—
—
0
0
113
946
1.25
1.28
1.3
1.3
—
—
—
0
0
16
93
1.74
1.22
5.7
5.8
10.94
11.59
mmol/l
0.42
16
88
16
93
1.74
1.22
5.7
5.8
103.75
105.13
mmol/l
0.36
16
88
5
19
2.65
1.22
1.8
3.5
36.16
46.06
%
—
5
19
25
367
0.66
1.19
4.5
2.4
0.32
0.38
e6/l
0.22
25
345
14
79
1.79
1.18
1.5
1.1
—
—
—
0
0
0
35
0.00
1.15
0.0
3.9
—
18.40
—
0
29
41
302
1.39
1.15
4.1
3.7
0.74
0.80
%
0.08
19
66
114
974
1.22
1.07
2.8
2.4
4.27
4.28
e6/l
0.00
104
880
21
309
0.67
1.03
2.2
2.9
6.17
6.05
ph
0.18
15
228
5
108
0.46
1.02
1.2
1.8
46.00
44.94
nmol/l
—
5
100
39
293
1.36
0.99
4.3
3.8
0.12
0.07
%
0.23
17
57
40
304
1.34
0.96
4.3
3.9
0.05
0.00
%
0.48
19
55
6
27
2.24
0.93
4.3
2.1
48.67
36.23
mg/l
—
6
22
103
1191
0.83
0.93
5.0
4.0
0.00
0.00
estimate
-0.00
41
372
6
29
2.08
0.89
1.0
1.1
—
—
—
0
0
5
105
0.47
0.89
1.2
1.3
1103.00
527.99
mg/l
—
5
100
14
217
0.63
0.89
1.0
1.3
—
—
—
0
0
8
44
1.83
0.86
1.1
1.1
—
—
—
0
0
0
24
0.00
0.79
0.0
1.3
—
94.13
—
0
24
57
687
0.81
0.79
1.4
1.3
0.85
1.65
u/ml
—
6
181
6
34
1.77
0.76
1.2
1.2
—
—
—
0
0
22
158
1.41
0.76
1.1
1.3
—
—
—
0
0
36
282
1.30
0.73
3.8
3.6
24.93
24.22
mmol/l
0.53
36
276
273
2886
0.88
0.72
43.2
20.3
14.60
13.77
%
13.84
273
2841
177
1623
1.14
0.71
3.9
3.3
1247.15
1786.97
ng/l
1.85
164
1427
6
103
0.58
0.62
1.3
1.1
—
—
—
0
0
52
614
0.83
0.61
1.5
1.3
2.02
2.84
g/l
1.56
28
356
0
20
0.00
0.60
0.0
1.2
—
0.49
—
0
15
0
21
0.00
0.60
0.0
3.7
—
29.71
—
0
14
0
23
0.00
0.58
0.0
1.3
—
—
—
0
0
6
35
1.72
0.58
1.0
1.1
—
—
—
0
0
15
107
1.41
0.56
1.1
1.2
—
—
—
0
0
10
65
1.55
0.56
3.2
2.8
1.18
1.18
mmol/l
—
10
65
81
912
0.87
0.55
1.6
1.8
1006.68
1139.52
nmol/l
0.66
53
692
29
359
0.80
0.54
2.2
2.2
105.79
191.48
ug/g
2.30
24
290
11
74
1.50
0.54
1.0
1.3
—
—
—
0
0
154
1656
0.90
0.50
2.9
3.1
365.08
150.28
ug/l
2.72
147
1519
7
45
1.56
0.49
1.0
1.2
—
—
—
0
0
10
68
1.48
0.47
3.2
2.7
105.00
104.62
mmol/l
—
10
68
10
68
1.48
0.47
3.2
2.7
4.34
4.13
mmol/l
—
10
68
29
352
0.81
0.47
2.2
2.0
0.00
0.00
estimate
—
5
59
95
1045
0.89
0.46
4.3
3.5
0.03
0.00
estimate
0.41
39
320
5
31
1.62
0.43
1.2
1.3
151.00
94.87
pmol/l
—
5
31
0
16
0.00
0.41
0.0
1.0
—
35.99
—
0
10
0
16
0.00
0.41
0.0
7.4
—
25.14
—
0
16
0
17
0.00
0.40
0.0
3.7
—
—
—
0
0
0
19
0.00
0.39
0.0
1.0
—
69.57
—
0
14
0
19
0.00
0.39
0.0
3.8
—
—
—
0
0
19
152
1.26
0.37
1.9
2.6
211.11
261.98
mg/l
—
9
51
113
1215
0.91
0.37
3.3
3.1
0.81
0.78
ug/l
0.17
88
873
44
386
1.15
0.36
1.7
1.6
—
—
—
0
0
65
587
1.12
0.35
3.1
2.0
1.75
1.75
%
0.01
59
520
21
172
1.23
0.35
1.1
1.4
—
—
—
0
0
355
3631
0.92
0.34
39.9
16.6
49.04
27.36
mg/l
15.90
340
2997
26
220
1.19
0.32
4.8
4.0
0.85
0.85
%
0.03
26
212
22
262
0.83
0.32
3.7
3.1
25.69
25.16
mmol/l
0.40
22
255
8
62
1.30
0.28
1.9
5.3
7.27
7.60
mmol/l
—
8
52
58
529
1.11
0.28
3.8
3.5
6.04
5.86
kpa
0.50
58
514
59
540
1.11
0.27
3.7
3.5
7.38
7.38
ph
0.29
35
337
118
1246
0.93
0.26
4.1
3.3
—
—
—
0
0
5
71
0.70
0.26
1.0
1.1
—
—
—
0
0
5
73
0.68
0.26
1.0
1.6
—
—
—
0
0
21
245
0.85
0.25
1.3
1.2
—
—
—
0
0
10
78
1.29
0.24
1.0
1.1
—
—
—
0
0
273
2662
1.06
0.23
5.0
4.6
—
3.43
—
0
6
28
316
0.88
0.23
1.3
1.4
—
—
—
0
0
67
623
1.09
0.23
1.5
1.3
28.37
36.46
iu/ml
0.37
15
179
61
566
1.09
0.22
1.3
1.3
27.34
12.42
u/ml
0.38
15
191
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
167.38
—
0
6
0
10
0.00
0.21
0.0
15.5
—
870.20
—
0
10
0
10
0.00
0.21
0.0
9.0
—
8.16
—
0
10
0
10
0.00
0.21
0.0
8.3
—
0.67
—
0
10
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
5
43
1.16
0.21
1.2
1.2
—
—
—
0
0
17
145
1.18
0.21
1.3
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
19.88
—
0
8
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
7.4
—
5.36
—
0
14
0
14
0.00
0.20
0.0
1.0
—
1811.43
—
0
14
48
443
1.09
0.20
4.7
2.5
12.59
4.95
e9/l
0.54
39
367
15
127
1.19
0.20
3.8
3.9
—
—
—
0
0
47
435
1.09
0.18
1.9
3.2
164.88
260.91
ng/l
1.66
41
404
32
351
0.91
0.17
1.5
1.3
—
—
—
0
0
49
458
1.08
0.16
2.3
1.9
65.90
66.92
e9/l
0.07
34
343
26
236
1.11
0.15
4.5
4.0
1.78
1.63
%
0.45
26
229
103
1070
0.95
0.14
2.9
2.7
344.03
369.25
umol/l
1.41
87
907
16
141
1.14
0.14
1.1
1.3
—
—
—
0
0
19
170
1.12
0.13
2.3
1.8
—
—
—
0
0
17
151
1.13
0.13
1.3
1.5
1.34
9.48
iu/ml
—
5
37
121
1175
1.04
0.12
2.2
2.3
3.42
2.84
mg/l
1.56
109
996
217
2202
0.97
0.09
5.2
3.2
58.74
53.03
u/l
0.39
202
2025
6
56
1.07
0.08
1.0
1.2
19.30
89.47
mu/l
—
6
50
6
57
1.05
0.08
1.0
1.2
—
0.40
—
0
5
5
60
0.83
0.08
2.0
4.2
11.60
11.85
pmol/l
—
5
60
5
62
0.80
0.08
1.0
1.0
—
—
—
0
0
52
501
1.04
0.07
1.2
1.2
—
—
—
0
0
33
315
1.05
0.06
1.5
1.5
—
—
—
0
0
183
1809
1.02
0.05
5.4
4.4
35.65
90.38
ng/l
1.28
161
1432
20
211
0.95
0.04
2.4
2.5
—
—
—
0
0
76
747
1.02
0.03
6.7
4.1
—
—
—
0
0
142
1429
0.99
0.01
2.6
2.2
295.54
287.10
u/l
0.04
136
1326
13
125
1.04
0.00
1.8
2.8
56.68
60.56
%
0.27
13
120
16
156
1.03
0.00
1.4
1.3
35.80
105.44
u/ml
—
6
63
28
282
0.99
0.00
1.4
1.5
—
—
—
0
0
11
111
0.99
0.00
1.3
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.0
—
72.88
—
0
8
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
15.16
—
0
5
5
53
0.94
-0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
78.60
—
0
5
7
71
0.99
-0.00
1.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
7
78
0.90
-0.00
1.3
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
88
0.91
-0.00
1.4
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
74.67
—
0
6
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
181.80
—
0
5
0
9
0.00
-0.00
0.0
1.7
—
7.51
—
0
9
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
54
0.93
-0.00
1.4
2.6
—
—
—
0
0
5
54
0.93
-0.00
1.4
1.2
0.98
0.94
g/l
—
5
54

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_MESOTHELIOMA_WIDE – Mesothelioma, including Hilmo

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).