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Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx, including Hilmo

Endpoint Browser

C3_LIP_ORAL_PHARYNX_NAS_WIDE

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — C14
  • Hospital discharge: ICD-9 — 149
  • Hospital discharge: ICD-8 — 149
  • Cause of death: ICD-10 — C14
  • Cause of death: ICD-9 — 149
  • Cause of death: ICD-8 — 149
  • Cancer registry: Topography ICD-O-3 — C14
  • Cancer registry: Morphology ICD-O-3 — ANY
  • Cancer registry: Behaviour codes — 3

3 out of 7 registries used, show all original rules.

106

4. Check minimum number of events

None

106

5. Include endpoints

None

106

6. Filter based on genotype QC (FinnGen only)

97

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

First used in FinnGen datafreeze
DF12

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 97 20 77
Unadjusted period prevalence (%) 0.03 0.01 0.04
Median age at first event (years) 67.43 65.36 67.96

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
101
Matched controls
1010
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
130
Kela drug reimbursment
Malignant tumour
+∞
44.0
39
*
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
252.4
35.2
34
*
A03FA01
ATC
metoclopramide; systemic, rectal
13.4
34.9
42
51
WF002
NOMESCO Finland
Radical radiotherapy
+∞
34.3
31
*
JDB10
NOMESCO Finland
Percutaneous gastrostomy
463.2
34.0
32
*
C14.0
ICD-10 Finland
Malignant neoplasm: Pharynx, unspecified
+∞
29.6
27
*
WZC00
NOMESCO Finland
Treatment plan or consultation
9.3
29.2
61
142
UJC01
NOMESCO Finland
Scopy of lower throat
76.3
25.6
28
5
C14.1
ICD-10 Finland
Malignant neoplasm of laryngopharynx unspecified
+∞
25.0
23
*
UDQ12
NOMESCO Finland
Flexible laryngoscopy
10.8
23.5
30
38
N02AA05
ATC
oxycodone; systemic
7.9
22.3
41
80
H02AB02
ATC
dexamethasone; systemic
97.9
21.7
23
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
21.6
20
*
R13
ICD-10 Finland
Dysphagia
9.5
20.2
28
39
XX3DW
NOMESCO Finland
Time consuming IT work
21.0
18.9
28
18
8070/3-C14.0
ICD-O-3
Squamous cell carcinoma, NOS, of pharynx, NOS
+∞
18.3
17
*
GBB00
NOMESCO Finland
Tracheostomy
61.5
17.7
20
*
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
77.0
17.4
19
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
24.3
16.5
23
12
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
16.1
15
*
A04AA02
ATC
granisetron; systemic, transdermal
+∞
16.1
15
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
35.1
15.9
20
7
UDQ22
NOMESCO Finland
Microlaryngoscopy
67.3
15.3
17
*
ENA10
NOMESCO Finland
Biopsy of pharynx
+∞
15.0
14
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
13.9
13
*
C14.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of lip, oral cavity and pharynx
+∞
13.9
13
*
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
+∞
13.9
13
*
DQB10
NOMESCO Finland
Endoscopic excision of lesion of larynx
160.7
13.8
14
*
C32.0
ICD-10 Finland
Malignant neoplasm: Glottis
+∞
12.8
12
*
A04AA01
ATC
ondansetron; systemic, rectal
31.2
12.5
16
6
R4190
NOMESCO Finland
Nutritional therapy
34.8
12.0
15
5
JN4AD
NOMESCO Finland
Body CT examination
12.9
12.0
21
20
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
73.7
11.9
13
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
4.2
11.6
56
231
D14.1
ICD-10 Finland
Benign neoplasm: Larynx
67.3
10.9
12
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
+∞
10.6
10
*
DQA10
NOMESCO Finland
Biopsy of larynx
+∞
10.6
10
*
ZX095
NOMESCO Finland
Combined chemoradiotherapy
+∞
10.6
10
*
C13.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of hypopharynx
+∞
10.6
10
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
10.6
10
*
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
+∞
10.6
10
*
WX408
NOMESCO Finland
General anesthesy, balanced
4.2
10.4
37
121
Z51.5
ICD-10 Finland
Palliative care
12.6
10.3
18
17
SAA03
NOMESCO Finland
Extended examination of mouth
3.9
10.1
48
192
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
61.0
9.9
11
*
EBA15
NOMESCO Finland
Extraction of multiple teeth
12.5
9.7
17
16
C13.9
ICD-10 Finland
Malignant neoplasm: Hypopharynx, unspecified
+∞
9.5
9
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
9.5
9
*
C32.9
ICD-10 Finland
Malignant neoplasm: Larynx, unspecified
+∞
9.5
9
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
9.5
9
*
DQB30
NOMESCO Finland
Laryngectomy
+∞
9.5
9
*
TJD20
NOMESCO Finland
Change of gastrostomy tube
+∞
9.5
9
*
UJC12
NOMESCO Finland
Flexible oesophagoscopy
+∞
9.5
9
*
8070/3-C32.9
ICD-O-3
Squamous cell carcinoma, NOS, of larynx, NOS
+∞
9.5
9
*
EJA10
NOMESCO Finland
Biopsy of tongue or floor of mouth
40.7
9.2
11
*
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
4.6
9.0
25
67
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.6
8.8
42
166
SCA02
NOMESCO Finland
Preventive oral health care
5.7
8.7
18
37
UGC12
NOMESCO Finland
Flexible bronchoscopy
7.8
8.7
20
31
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
97.9
8.6
9
*
R21
ICPC
Throat symptom/complaint
4.3
8.5
26
75
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
+∞
8.4
8
*
PJD81
NOMESCO Finland
Excision of lymph nodes from upper part of neck
+∞
8.4
8
*
YA1VG
NOMESCO Finland
MRI examination of head and neck with high intesity magnet for dose design of radiotherapy
+∞
8.4
8
*
D38.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Larynx
+∞
8.4
8
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
8.4
8
*
C77.0
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Lymph nodes of head, face and neck
+∞
8.4
8
*
UDH02
NOMESCO Finland
Rhinopharyngoscopy
7.8
8.4
19
29
WZC30
NOMESCO Finland
Teaching
4.3
8.3
26
76
EBA10
NOMESCO Finland
Operative extraction of tooth
4.9
8.2
20
48
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
13.3
7.8
13
11
UDQ02
NOMESCO Finland
Direct laryngoscopy
27.4
7.7
10
*
SXA10
NOMESCO Finland
Oral mucosal sampling
86.1
7.5
8
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
86.1
7.5
8
*
WW500
NOMESCO Finland
Blood transfusion
17.4
7.4
11
7
116
Kela drug reimbursment
Prostate cancer
+∞
7.4
7
*
C32.1
ICD-10 Finland
Malignant neoplasm: Supraglottis
+∞
7.4
7
*
L03AA02
ATC
filgrastim; parenteral
+∞
7.4
7
*
D10.9
ICD-10 Finland
Benign neoplasm: Pharynx, unspecified
+∞
7.4
7
*
DQE00
NOMESCO Finland
Implantation of prosthetic replacement for larynx
+∞
7.4
7
*
GD1AD
NOMESCO Finland
Thorax CT examination
6.8
7.3
18
31
H03AA01
ATC
levothyroxine sodium; systemic
3.5
7.0
30
109
K05.31
ICD-10 Finland
Periodontitis pronounced
4.1
6.6
20
57
OAB73
NOMESCO Finland
Prevention and treatment of malnutrition
74.3
6.5
7
*
GD6AD
NOMESCO Finland
CT of chest and neck
74.3
6.5
7
*
A07AA02
ATC
nystatin; oral
6.6
6.5
16
28
C09.0
ICD-10 Finland
Malignant neoplasm: Tonsillar fossa
+∞
6.3
6
*
Z51.0
ICD-10 Finland
Radiotherapy session
+∞
6.3
6
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
6.3
6
*
JN4KR
NOMESCO Finland
Whole body very extensive metabolic PET with CT
+∞
6.3
6
*
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
+∞
6.3
6
*
C32.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of larynx
+∞
6.3
6
*
JCA55
NOMESCO Finland
Endoscopic dilatation of oesophagus
+∞
6.3
6
*
A04AD12
ATC
aprepitant; systemic
+∞
6.3
6
*
JDB00
NOMESCO Finland
Gastrostomy
+∞
6.3
6
*
D37.08
ICD-10 Finland
Tumor of uncertain or unknown nature in other part of lip, oral cavity and pharynx
+∞
6.3
6
*
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
+∞
6.3
6
*
8070/3-C13.9
ICD-O-3
Squamous cell carcinoma, NOS, of hypopharynx, NOS
+∞
6.3
6
*
TGB20
NOMESCO Finland
Tracheostomy tube replacement
+∞
6.3
6
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
6.3
6
*
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
11.0
6.2
11
11
R07.0
ICD-10 Finland
Pain in throat
8.9
6.0
12
15

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
29
20
19.80
19.11
1.8
1.3
—
—
—
0
0
43
121
5.45
15.32
6.0
2.8
0.77
0.84
mmol/l
4.60
43
115
29
60
6.38
14.37
3.1
1.6
0.21
0.23
g/l
0.52
29
49
69
300
5.10
14.02
4.5
2.4
—
—
estimate
—
0
0
55
219
4.32
12.11
3.5
1.5
—
—
—
0
0
75
389
4.61
11.10
12.9
5.4
4.53
4.18
e9/l
0.76
67
333
30
93
4.17
8.95
2.5
1.8
—
—
—
0
0
46
207
3.24
7.67
4.2
3.9
—
—
—
0
0
47
215
3.22
7.61
4.3
2.1
—
—
—
0
0
21
56
4.47
7.54
1.7
1.1
—
—
—
0
0
62
374
2.70
5.53
12.2
6.5
1.21
1.21
mmol/l
0.18
57
329
45
237
2.62
5.22
6.4
5.1
—
—
—
0
0
61
375
2.58
5.08
16.7
14.8
1.21
1.30
inr
0.61
51
304
61
376
2.57
5.04
6.9
5.3
1.61
1.80
e9/l
1.00
54
325
60
372
2.51
4.83
6.3
5.2
0.67
0.59
e9/l
1.01
51
314
61
382
2.51
4.79
6.8
5.2
0.18
0.20
e9/l
0.28
53
329
60
373
2.50
4.79
7.0
5.2
0.05
0.04
e9/l
1.35
51
318
29
135
2.61
4.20
2.3
2.2
2.47
2.43
mmol/l
0.68
23
108
8
10
8.57
4.14
1.0
1.1
—
—
—
0
0
25
117
2.51
3.54
2.4
1.8
—
—
—
0
0
22
98
2.59
3.43
15.8
7.8
7.42
7.42
ph
0.06
12
62
37
210
2.20
3.37
6.4
4.0
7.41
7.40
ph
0.62
28
150
24
113
2.47
3.34
13.4
7.3
103.00
103.82
mmol/l
0.25
24
113
21
94
2.56
3.24
16.1
8.1
1.37
1.31
mmol/l
0.02
15
82
13
47
3.03
2.94
1.2
1.6
11.17
10.46
g/l
0.22
13
42
28
152
2.17
2.79
4.0
3.8
—
—
—
0
0
5
6
8.68
2.78
1.0
1.0
—
—
—
0
0
38
239
1.95
2.53
3.5
2.2
66.67
75.35
u/l
0.17
33
223
31
182
2.01
2.50
1.5
1.3
—
—
—
0
0
14
58
2.64
2.50
2.9
3.2
—
—
—
0
0
11
40
2.96
2.36
21.4
11.9
24.68
24.22
mmol/l
0.17
11
40
11
42
2.81
2.22
3.7
3.8
1.26
1.21
mmol/l
0.94
11
34
14
62
2.46
2.19
6.5
3.5
—
—
—
0
0
62
475
1.79
2.09
4.5
3.8
—
35.67
—
0
6
18
93
2.14
2.00
1.3
1.6
—
—
—
0
0
18
94
2.11
1.95
1.3
1.8
—
—
—
0
0
29
181
1.84
1.92
3.7
2.9
—
—
—
0
0
5
14
3.70
1.63
6.4
2.1
9.80
10.71
mmol/l
—
5
14
85
742
1.92
1.59
29.2
13.7
27.71
26.12
mg/l
0.21
78
595
14
72
2.10
1.58
1.3
1.4
—
—
—
0
0
11
51
2.30
1.57
21.8
11.6
95.86
92.12
%
2.38
11
51
11
51
2.30
1.57
21.8
11.5
0.54
0.70
%
0.69
11
51
27
175
1.74
1.56
2.1
2.1
7.88
3.76
e6/l
0.57
21
157
13
66
2.11
1.51
20.3
10.8
—
—
—
0
0
11
52
2.25
1.50
21.5
11.4
1.63
1.65
%
0.02
11
52
35
247
1.64
1.47
2.9
2.8
88.06
286.87
e6/l
0.33
26
186
17
97
1.90
1.46
1.8
3.6
7.41
7.38
ph
—
7
60
66
546
1.60
1.41
5.6
3.9
14.17
14.99
pmol/l
1.55
58
490
29
199
1.64
1.35
2.8
2.6
—
0.00
estimate
—
0
5
31
217
1.62
1.34
2.9
2.7
1.20
0.23
e6/l
0.75
23
156
16
96
1.79
1.19
3.1
3.6
2.38
1.91
mmol/l
0.18
16
82
43
334
1.50
1.16
11.8
10.2
0.00
0.00
e9/l
0.49
36
275
8
40
2.08
1.15
3.3
2.3
—
—
—
0
0
29
207
1.56
1.14
9.3
4.3
—
—
—
0
0
8
41
2.03
1.11
1.0
1.5
—
—
—
0
0
22
148
1.62
1.10
1.7
2.6
476.82
557.68
mosm/kgh2o
1.19
17
127
9
49
1.92
1.02
4.4
2.4
2.28
1.12
%
—
9
49
9
49
1.92
1.02
4.4
2.4
0.67
0.52
%
—
9
49
0
28
0.00
0.99
0.0
1.5
—
—
—
0
0
0
28
0.00
0.99
0.0
1.1
—
1.43
—
0
28
7
36
2.01
0.99
1.1
1.2
—
—
—
0
0
12
71
1.78
0.93
1.1
1.6
—
—
—
0
0
6
28
2.21
0.93
2.7
1.5
—
—
—
0
0
16
104
1.64
0.91
1.3
1.3
—
—
—
0
0
35
275
1.42
0.85
3.2
3.4
234.24
105.72
e6/l
0.42
26
195
23
167
1.49
0.83
4.5
3.5
279.39
320.37
ng/l
0.05
18
142
0
26
0.00
0.79
0.0
1.2
—
0.82
—
0
5
5
28
1.83
0.67
3.8
4.2
4.06
3.96
mmol/l
—
5
28
70
762
0.73
0.66
5.6
6.4
2.61
2.60
mmol/l
0.02
63
698
8
49
1.69
0.64
2.8
2.3
—
—
—
0
0
75
689
1.34
0.59
7.1
4.8
3.24
1.97
mu/l
2.81
68
608
69
745
0.77
0.54
4.8
5.5
1.38
1.39
mmol/l
0.02
61
680
69
744
0.77
0.52
5.6
7.1
38.91
40.82
mmol/mol
1.47
62
694
83
780
1.36
0.51
22.9
12.7
—
—
—
0
0
70
752
0.77
0.50
5.2
5.6
4.47
4.48
mmol/l
0.01
63
690
67
613
1.28
0.50
29.8
16.2
14.10
13.57
%
2.12
67
607
27
322
0.78
0.47
4.0
4.4
12.61
9.15
mg/mmol
0.18
16
207
27
223
1.29
0.46
3.4
3.3
0.00
0.00
estimate
—
6
75
7
50
1.43
0.46
3.7
2.8
—
—
—
0
0
8
56
1.46
0.44
3.3
2.4
7.41
7.42
ph
—
8
42
8
56
1.46
0.44
2.5
1.3
—
—
—
0
0
5
31
1.64
0.43
4.2
4.0
4.32
1.14
mmol/l
—
5
31
42
370
1.23
0.42
4.1
4.0
21.44
42.00
ng/l
2.42
35
274
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
23
273
0.80
0.38
3.1
2.7
0.67
0.75
ug/l
0.18
15
171
25
293
0.80
0.37
3.2
3.7
—
—
—
0
0
16
127
1.31
0.36
1.1
1.2
21.20
33.06
iu/ml
—
5
39
27
312
0.82
0.34
3.1
3.7
52.86
60.45
mg/l
0.09
16
207
8
65
1.25
0.28
3.6
3.9
717.13
166.29
ng/l
—
8
58
8
103
0.76
0.22
1.8
2.3
10.44
16.02
nmol/l
—
8
95
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
-0.52
—
0
10
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
2.4
—
4.16
—
0
14
0
14
0.00
0.20
0.0
2.4
—
105.36
—
0
14
0
14
0.00
0.20
0.0
2.4
—
1.19
—
0
14
32
348
0.88
0.19
2.2
2.1
104.61
93.77
pmol/l
0.58
16
172
7
62
1.14
0.17
1.0
1.2
—
—
—
0
0
5
68
0.72
0.17
1.2
1.4
—
—
—
0
0
70
722
0.90
0.14
4.1
4.6
1.31
1.34
mmol/l
0.14
61
655
20
218
0.90
0.11
4.3
2.7
0.00
0.00
estimate
—
6
62
7
80
0.87
0.07
1.4
1.3
—
—
—
0
0
7
82
0.84
0.07
1.1
1.4
—
—
—
0
0
73
737
0.97
0.01
5.1
5.2
5.92
6.16
mmol/l
1.31
66
667
31
304
1.03
0.00
4.5
3.3
7.15
6.15
ph
4.11
20
175
39
391
1.00
0.00
4.8
3.3
0.00
0.00
estimate
—
8
81
31
305
1.02
0.00
6.1
3.3
0.00
0.00
estimate
—
6
70
40
396
1.02
0.00
4.4
3.3
0.00
0.00
estimate
—
7
76
39
386
1.02
0.00
4.9
3.3
0.00
0.00
estimate
—
8
81
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
81.20
—
0
5
5
53
0.94
-0.00
2.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.7
—
0.59
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
275.00
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
1231.67
—
0
6
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0

Mortality – FinRegistry

↥

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

↥

Index endpoint: C3_LIP_ORAL_PHARYNX_NAS_WIDE – Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx, including Hilmo

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).