aspergillosis: Aspergillosis is an infection, growth, or allergic response caused by the Aspergillus fungus. There are several different kinds of aspergillosis. One kind is allergic bronchopulmonary aspergillosis (also called ABPA), a condition where the fungus causes allergic respiratory symptoms similar to asthma, such as wheezing and coughing, but does not actually invade and destroy tissue. Another kind of aspergillosis is invasive aspergillosis. This infection usually affects people with weakened immune systems due to cancer, AIDS, leukemia, organ transplantation, chemotherapy, or other conditions or events that reduce the number of normal white blood cells. In this condition, the fungus invades and damages tissues in the body. Invasive aspergillosis most commonly affects the lungs, but can also cause infection in many other organs and can spread throughout the body (commonly affecting the kidneys and brain). Aspergilloma , a growth (fungus ball) that develops in an area of previous lung disease such as tuberculosis or lung abscess , is a third kind of aspergillosis. This type of aspergillosis is composed of a tangled mass of fungus fibers, blood clots, and white blood cells. The fungus ball gradually enlarges, destroying lung tissue in the process, but usually does not spread to other areas.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
188 |
4. Check minimum number of eventsNone |
188 |
5. Include endpointsNone |
188 |
6. Filter based on genotype QC (FinnGen only) |
149 |
Control definitions (FinnGen only)
- Control exclude
- ASTHMA_COMORB
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- B44
- Name in latin
- Aspergillosis pulmonalis
Similar endpoints
↥List of similar endpoints to
Allergic bronchopulmonary aspergillosis (ABPA)
based on the number of shared cases.
Similar with more cases:
- Aspergillosis
- Aspergillosis, including avohilmo
- Mycoses
- Mycoses, including avohilmo
- Certain infectious and parasitic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 699 | 250 | 439 |
| Only index persons | 549 | 205 | 344 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 65.91 | 66.25 | 65.77 |
| Only index persons | 65.36 | 65.64 | 65.20 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 149 | 53 | 96 |
| Unadjusted period prevalence (%) | 0.04 | 0.02 | 0.04 |
| Median age at first event (years) | 65.39 | 60.60 | 68.03 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 156
- Matched controls
- 1560
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
B44.1
ICD-10 Finland
Other pulmonary aspergillosis
+∞
198.0
145
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
40.1
121.8
92
54
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
49.6
100.4
63
21
J18.9
ICD-10 Finland
Pneumonia, unspecified
28.3
94.6
124
188
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
22.5
88.4
88
85
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
27.3
85.8
69
44
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
50.0
83.4
51
15
J01MA14
ATC
moxifloxacin; systemic
21.4
79.0
74
63
R03BB04
ATC
tiotropium bromide; inhalant
22.0
78.2
71
57
J02AC03
ATC
voriconazole; systemic
332.9
76.9
72
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
21.6
75.1
68
54
GD1AD
NOMESCO Finland
Thorax CT examination
23.8
72.3
60
40
J45.1
ICD-10 Finland
Nonallergic asthma
31.6
66.7
47
21
GD1AA
NOMESCO Finland
Thorax X-ray examination
23.6
64.4
136
349
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
22.4
62.7
52
34
J45.9
ICD-10 Finland
Asthma, unspecified
13.9
59.1
73
93
R04.2
ICD-10 Finland
Haemoptysis
28.4
57.9
42
20
H02AB06
ATC
prednisolone; systemic
18.9
57.7
133
366
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
31.3
57.5
40
17
TGC00
NOMESCO Finland
Bronchial lavation
130.2
56.6
58
7
J45.0
ICD-10 Finland
Predominantly allergic asthma
18.9
56.5
51
39
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
12.3
56.2
81
126
R03AK06
ATC
salmeterol and fluticasone; inhalant
13.2
53.4
65
80
J01MA12
ATC
levofloxacin; systemic
11.1
51.7
82
142
H25.1
ICD-10 Finland
Senile nuclear cataract
20.9
50.5
42
27
R03AC12
ATC
salmeterol; inhalant
24.3
47.2
36
19
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
18.3
42.2
37
26
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
17.0
41.5
38
29
R03DC03
ATC
montelukast; oral
9.9
40.4
60
93
R03BA05
ATC
fluticasone; inhalant
9.0
39.5
67
121
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
12.1
37.9
44
49
J47
ICD-10 Finland
Bronchiectasis
64.3
34.4
39
8
R03DA04
ATC
theophylline; systemic, rectal
13.4
33.5
35
33
R50.9
ICD-10 Finland
Fever, unspecified
8.2
32.8
56
100
A49.9
ICD-10 Finland
Bacterial infection, unspecified
9.7
31.9
44
61
R06.0
ICD-10 Finland
Dyspnoea
7.1
31.8
68
153
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
+∞
30.2
28
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
8.6
30.1
46
72
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
7.4
29.7
119
471
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
9.1
29.2
42
61
T90
ICPC
Diabetes non-insulin dependent
13.5
28.4
29
26
WX892
NOMESCO Finland
Monitored bed care
13.5
28.4
29
26
H02AB04
ATC
methylprednisolone; systemic
7.4
28.4
52
99
C03CA01
ATC
furosemide; systemic
6.8
28.3
59
128
H02AB07
ATC
prednisone; oral
9.1
28.2
40
57
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
6.0
28.0
87
272
R03AC02
ATC
salbutamol; inhalant
6.5
26.9
115
469
103
Kela drug reimbursment
Diabetes, insulin-treated
+∞
26.8
25
*
XF400
NOMESCO Finland
ECG with 12 standard connections
8.2
26.8
42
67
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
6.7
26.8
55
117
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
11.7
26.8
30
31
B44.0
ICD-10 Finland
Invasive pulmonary aspergillosis
309.5
26.6
26
*
B44.9
ICD-10 Finland
Aspergillosis, unspecified
+∞
25.7
24
*
I25.1
ICD-10 Finland
Atherosclerotic heart disease
58.8
25.3
29
6
J45
ICD-10 Finland
Asthma
9.4
25.3
34
45
M05BA04
ATC
alendronic acid; oral
11.3
25.2
29
31
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
8.7
24.9
36
52
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
9.8
24.8
32
40
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
6.8
24.7
48
96
215
Kela drug reimbursment
Diabetes, non-insulin-treated
+∞
24.6
23
*
TPH04
NOMESCO Finland
Cathetrisation of vein
6.0
24.5
58
140
R03BA08
ATC
ciclesonide; inhalant
9.6
24.4
32
41
R03BA01
ATC
beclometasone; inhalant
6.7
24.1
47
94
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
11.5
23.9
27
28
R03AK08
ATC
formoterol and beclometasone; inhalant
23.8
23.9
34
18
I48
ICD-10 Finland
Atrial fibrillation and flutter
77.3
23.6
26
*
B44.8
ICD-10 Finland
Other forms of aspergillosis
+∞
22.4
21
*
ZX120
NOMESCO Finland
Intravenous
7.9
21.9
34
53
ZXD05
NOMESCO Finland
Urgent procedure
5.2
21.6
62
175
B01AA03
ATC
warfarin; systemic
9.1
21.6
29
38
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
7.0
21.3
38
69
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
9.7
21.2
27
33
R03BA02
ATC
budesonide; inhalant
5.7
21.2
50
119
J01FA06
ATC
roxithromycin; oral
4.7
20.8
93
370
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
5.1
20.8
61
175
J17.2*B44.1
ICD-10 Finland
Pneumonia in other aspergillosis
+∞
20.2
19
*
A31.0
ICD-10 Finland
Pulmonary mycobacterial infection
227.7
20.0
20
*
J01FF01
ATC
clindamycin; systemic
4.8
19.6
64
199
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
32.7
19.4
25
9
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
+∞
19.1
18
*
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
21.0
19.1
28
16
R81
ICPC
Pneumonia
18.4
18.9
29
19
C07AB07
ATC
bisoprolol; oral
4.4
18.7
74
265
A02BC02
ATC
pantoprazole; systemic
5.4
18.6
124
649
XG410
NOMESCO Finland
Flow-volume spirometry
23.7
18.5
26
13
A10BA02
ATC
metformin; oral
42.3
18.2
22
6
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
+∞
18.1
17
*
TPH07
NOMESCO Finland
Cathetrisation of artery
6.6
18.0
33
61
WX302
NOMESCO Finland
Thoracal epidural anesthesy
8.7
17.5
24
32
WX408
NOMESCO Finland
General anesthesy, balanced
4.4
17.4
61
198
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
26.7
17.0
23
10
Z3231
NOMESCO Finland
Registered nurse
4.5
16.9
55
168
GDC00
NOMESCO Finland
Lobectomy of lung
189.4
16.8
17
*
207
Kela drug reimbursment
Chronic arrhythmias
189.4
16.8
17
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
19.6
16.7
25
15
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
34.3
16.6
21
7
127
Kela drug reimbursment
Transplant complication
67.3
16.1
18
*
R03AC13
ATC
formoterol; inhalant
14.6
16.1
27
22
A10AB05
ATC
insulin aspart; parenteral
94.8
15.9
17
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
4.1
15.6
59
200
J46
ICD-10 Finland
Status asthmaticus
35.7
15.2
19
6
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
5.1
15.1
37
89
R02
ICPC
Shortness of breath/dyspnoea
6.1
15.0
29
56
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
164.8
14.7
15
*
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
21.8
14.7
21
11
J01MA02
ATC
ciprofloxacin; systemic
3.7
14.5
78
334
R03AK07
ATC
formoterol and budesonide; inhalant
4.3
14.4
46
137
AA1AD
NOMESCO Finland
CT of head and brain
4.0
14.3
54
182
ZXA10
NOMESCO Finland
Bilateral
5.7
14.2
30
63
C01DA14
ATC
isosorbide mononitrate; oral
26.8
14.2
19
8
WX872
NOMESCO Finland
Intensive care
59.0
14.1
16
*
R4110
NOMESCO Finland
Physiotherapy
3.9
14.1
56
195
WX002
NOMESCO Finland
Sedation and analgesia
4.6
14.0
40
109
J01FA15
ATC
telithromycin; oral
5.6
14.0
30
64
JN4BD
NOMESCO Finland
Extensive body CT
4.8
13.9
37
95
J01AA02
ATC
doxycycline; systemic
6.4
13.9
140
901
H26.4
ICD-10 Finland
After-cataract
82.2
13.8
15
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
6.2
13.8
26
49
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
15.8
13.7
22
16
49300
ICD-8 Finland
Asthma, bronchiale
25.2
13.2
18
8
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
54.9
13.1
15
*
J01FA09
ATC
clarithromycin; systemic
3.5
13.0
65
262
ZXE00
NOMESCO Finland
One hour or less
3.5
12.9
66
269
Z2221
NOMESCO Finland
Medical doctor
3.9
12.9
50
170
R03AC03
ATC
terbutaline; inhalant
5.1
12.9
31
73
J45.8
ICD-10 Finland
Mixed asthma
22.4
12.8
18
9
WX100
NOMESCO Finland
Conjunctival surface anesthesia
22.4
12.8
18
9
WX404
NOMESCO Finland
Intravenous generell anesthesy
4.2
12.7
41
122
AN1
HP
Coronary angiography
+∞
12.7
12
*
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
140.9
12.6
13
*
J02AC05
ATC
isavuconazole; systemic
140.9
12.6
13
*
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
140.9
12.6
13
*
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
29.4
12.3
16
6
A02BC01
ATC
omeprazole; systemic
3.6
12.3
53
193
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
6.2
12.0
22
40
R06AE07
ATC
cetirizine; oral
3.3
11.9
76
352
A02BC05
ATC
esomeprazole; systemic
3.3
11.9
69
302
A10AC01
ATC
insulin (human); parenteral
70.4
11.8
13
*
J02AC04
ATC
posaconazole; systemic
70.4
11.8
13
*
R96
ICPC
Asthma
6.1
11.7
22
41
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
10.9
11.7
22
23
J01.0
ICD-10 Finland
Acute maxillary sinusitis
3.7
11.7
46
157
J01FA10
ATC
azithromycin; systemic
3.3
11.7
99
540
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
129.1
11.6
12
*
H25.8
ICD-10 Finland
Other senile cataract
129.1
11.6
12
*
A10AE04
ATC
insulin glargine; parenteral
129.1
11.6
12
*
Z3226
NOMESCO Finland
Physiotherapist
4.4
11.6
33
89
Z01.8
ICD-10 Finland
Other specified special examinations
3.6
11.4
47
165
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
27.4
11.4
15
6
L04AA06
ATC
mycophenolic acid; systemic
27.4
11.4
15
6
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
6.2
11.0
20
36
JN4AD
NOMESCO Finland
Body CT examination
4.1
10.9
35
103
ZXA05
NOMESCO Finland
Left side
3.5
10.9
47
170
N03AX16
ATC
[U] pregabalin
3.6
10.8
44
153
N02AX02
ATC
tramadol; systemic, rectal
3.1
10.7
76
369
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
17.6
10.6
16
10
J02AC01
ATC
fluconazole; systemic
3.2
10.6
60
256
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
117.6
10.6
11
*
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
117.6
10.6
11
*
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
35.2
10.5
13
*
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
14.5
10.4
17
13
I50.9
ICD-10 Finland
Heart failure, unspecified
9.8
10.1
20
23
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
5.3
10.1
22
47
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
10.6
10.1
19
20
B02AA02
ATC
tranexamic acid; systemic
4.5
10.1
27
69
N02AA05
ATC
oxycodone; systemic
3.4
10.0
45
166
J01CA04
ATC
amoxicillin; systemic
4.2
10.0
134
922
R03DC01
ATC
zafirlukast; oral
28.1
10.0
13
5
R01AD09
ATC
mometasone; nasal
2.9
9.9
76
382
SPAT1262
SPAT
Handing over of treatment supplies
5.2
9.9
22
48
A07AA02
ATC
nystatin; oral
10.1
9.9
19
21
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
12.6
9.8
17
15
UDH02
NOMESCO Finland
Rhinopharyngoscopy
7.8
9.7
22
32
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
3.2
9.7
50
200
D64.9
ICD-10 Finland
Anaemia, unspecified
4.9
9.7
23
53
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
5.1
9.6
22
49
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
19.0
9.6
14
8
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
11.8
9.6
17
16
GDB11
NOMESCO Finland
Thoracoscopic wedge resection of lung
106.2
9.5
10
*
TFP20
NOMESCO Finland
Cardiodefibrillation
+∞
9.5
9
*
TGD04
NOMESCO Finland
Needle biopsy of the lungs in bronchoscopy
+∞
9.5
9
*
XW000
NOMESCO Finland
Bone marrow biopsy
7.9
9.4
21
30
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
5.3
9.4
20
42
R03AK11
ATC
formoterol and fluticasone; inhalant
12.6
9.3
16
14
B01AC04
ATC
clopidogrel; oral
8.3
9.3
20
27
B01AB05
ATC
enoxaparin; parenteral
2.9
9.3
60
273
WW200
NOMESCO Finland
Immunization
16.9
9.2
14
9
E11
ICD-10 Finland
Type 2 diabetes mellitus
25.8
9.1
12
5
Z2446
NOMESCO Finland
Social worker
10.4
9.0
17
18
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
10.4
9.0
17
18
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
15.2
8.9
14
10
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
53.0
8.8
10
*
A28
ICPC
Limited function/disability NOS
3.7
8.7
32
103
ZXA00
NOMESCO Finland
Right side
3.1
8.7
46
186
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
8.7
8.6
18
23
J43.9
ICD-10 Finland
Emphysema, unspecified
21.5
8.6
12
6
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
5.1
8.6
19
41
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
13.8
8.6
14
11
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
2.7
8.6
74
389
TPX10
NOMESCO Finland
Implantation of vascular injection port
10.3
8.5
16
17
XG499
NOMESCO Finland
Other fysiological examination of respiatory function
95.0
8.5
9
*
H02AB09
ATC
hydrocortisone; systemic
11.7
8.5
15
14
N02BE01
ATC
paracetamol; systemic, rectal
5.0
8.5
143
1072
E66.8
ICD-10 Finland
Other obesity
+∞
8.4
8
*
J01GB01
ATC
tobramycin; inhalant, parenteral
+∞
8.4
8
*
A10BH01
ATC
sitagliptin; oral
+∞
8.4
8
*
J85.1
ICD-10 Finland
Abscess of lung with pneumonia
+∞
8.4
8
*
SPAT1255
SPAT
Intravenous administration of medicine
7.0
8.3
20
32
J02AC02
ATC
itraconazole; systemic
3.3
8.3
37
135
R07.4
ICD-10 Finland
Chest pain, unspecified
3.2
8.3
38
141
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
10.9
8.2
15
15
L04AD02
ATC
tacrolimus; systemic
35.4
8.2
10
*
JN4CD
NOMESCO Finland
Very extensive body CT
6.8
8.2
20
33
R03AL06
ATC
olodaterol and tiotropium bromide; inhalant
23.5
8.1
11
5
B01AF02
ATC
apixaban; oral
8.5
8.1
17
22
J01DB01
ATC
cefalexin; oral
3.4
8.1
129
916
XG474
NOMESCO Finland
Exhalation nntrogen oxide
14.0
8.0
13
10
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
16.1
7.9
12
8
R01AD08
ATC
fluticasone; nasal
2.8
7.8
50
223
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
12.8
7.7
13
11
WW500
NOMESCO Finland
Blood transfusion
7.8
7.7
17
24
ZXE40
NOMESCO Finland
More than seven and less than nine hours
19.6
7.7
11
6
ZXE30
NOMESCO Finland
More than five and less than seven hours
10.9
7.7
14
14
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
7.1
7.7
18
28
UJF32
NOMESCO Finland
Coloscopy
3.0
7.6
42
173
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
9.1
7.5
15
18
J85.2
ICD-10 Finland
Abscess of lung without pneumonia
83.9
7.5
8
*
J10.0
ICD-10 Finland
Influenza with pneumonia, seasonal influenza virus identified
83.9
7.5
8
*
M04AA01
ATC
allopurinol; systemic
3.8
7.5
25
75
R03BB01
ATC
ipratropium bromide; inhalant
8.0
7.4
16
22
J17.2*B44.0
ICD-10 Finland
Pneumonia in invasive aspergillosis
+∞
7.3
7
*
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
+∞
7.3
7
*
J15.1
ICD-10 Finland
Pneumonia due to Pseudomonas
+∞
7.3
7
*
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
+∞
7.3
7
*
R01AD01
ATC
beclometasone; nasal
3.4
7.3
30
103
TDM10
NOMESCO Finland
Puncture of maxillary antrum
8.6
7.3
15
19
WZC30
NOMESCO Finland
Teaching
3.1
7.3
35
133
L04AD01
ATC
ciclosporin; systemic
21.2
7.2
10
5
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
31.6
7.2
9
*
F17.29
ICD-10 Finland
Addiction caused by tobacco UNS
31.6
7.2
9
*
CJB10
NOMESCO Finland
Laser discission of secondary cataract
31.6
7.2
9
*
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
9.5
7.2
14
16
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.5
7.1
69
376
A01AB04
ATC
amphotericin B; local oral
8.2
7.1
15
20
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
7.3
7.0
16
24
SPAT1263
SPAT
Sampling
2.6
7.0
58
293
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
8.9
7.0
14
17
L03AA02
ATC
filgrastim; parenteral
6.4
6.8
17
29
GD5AD
NOMESCO Finland
Thorax and upper abdomen combined CT examination of
41.9
6.8
8
*
A10BB12
ATC
glimepiride; oral
41.9
6.8
8
*
ZX108
NOMESCO Finland
Inhalation
41.9
6.8
8
*
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
8.4
6.8
14
18
I26.0
ICD-10 Finland
Pulmonary embolism with mention of acute cor pulmonale
23.7
6.8
9
*
ZXE20
NOMESCO Finland
More than three and less than five hours
3.4
6.7
26
86
WX882
NOMESCO Finland
High dependency care
13.0
6.7
11
9
G47.3
ICD-10 Finland
Sleep apnoea
3.0
6.7
34
133
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
10.7
6.7
12
12
WZC00
NOMESCO Finland
Treatment plan or consultation
2.4
6.6
63
338
A02BC03
ATC
lansoprazole; oral
2.6
6.5
45
207
XQ800
NOMESCO Finland
Prick test
6.5
6.5
16
27
J96.0
ICD-10 Finland
Acute respiratory failure
72.7
6.5
7
*
A10BK01
ATC
dapagliflozin; oral
72.7
6.5
7
*
J17.3*B59
ICD-10 Finland
Pneumonia due to Pneumocystis carinii
72.7
6.5
7
*
UGC18
NOMESCO Finland
Flexible bronchoscopy with biopsy of lung
72.7
6.5
7
*
R24
ICPC
Haemoptysis
72.7
6.5
7
*
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
8.7
6.5
13
16
A07EC01
ATC
sulfasalazine; oral, rectal
8.7
6.5
13
16
P01BA02
ATC
hydroxychloroquine; oral
8.7
6.5
13
16
A03
ICPC
Fever
3.1
6.5
30
111
A04AA01
ATC
ondansetron; systemic, rectal
3.6
6.4
23
72
J40
ICD-10 Finland
Bronchitis, not specified as acute or chronic
9.9
6.4
12
13
U07.1
ICD-10 Finland
Emergency use of U07.1 | COVID-19, virus identified
3.0
6.4
33
130
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
6.2
6.3
16
28
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
6.2
6.3
16
28
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
3.4
6.3
25
84
A05AA02
ATC
ursodeoxycholic acid; oral
27.9
6.3
8
*
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
+∞
6.3
6
*
FN2BA
NOMESCO Finland
Percutaneous transluminal coronary angioplasty with stent (includes balloon pre-dilation)
+∞
6.3
6
*
J98.1
ICD-10 Finland
Pulmonary collapse
+∞
6.3
6
*
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
+∞
6.3
6
*
J82
ICD-10 Finland
Pulmonary eosinophilia, not elsewhere classified
+∞
6.3
6
*
A31.9
ICD-10 Finland
Mycobacterial infection, unspecified
+∞
6.3
6
*
A10BK03
ATC
empagliflozin; oral
+∞
6.3
6
*
Z94.2
ICD-10 Finland
Lung transplant status
+∞
6.3
6
*
XF600
NOMESCO Finland
Bloodpressure measurement
7.2
6.2
14
21
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
13.2
6.2
10
8
J96.1
ICD-10 Finland
Chronic respiratory failure
13.2
6.2
10
8
R49.01
ICD-10 Finland
Functional dysphonia
10.7
6.1
11
11
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.0
6.1
18
49
XCK10
NOMESCO Finland
Photography of fundus of eye
7.8
6.1
13
18
J33.0
ICD-10 Finland
Polyp of nasal cavity
6.9
6.0
14
22
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
88
37
53.27
132.91
7.3
2.9
—
—
—
0
0
55
24
34.85
79.44
2.9
1.1
—
—
—
0
0
48
14
49.08
78.43
2.6
1.6
—
—
—
0
0
44
11
55.32
74.52
2.5
1.5
—
—
—
0
0
43
13
45.28
69.22
7.3
2.8
—
—
—
0
0
80
96
16.05
68.42
3.9
1.6
—
—
—
0
0
48
24
28.44
65.22
3.9
1.5
—
—
—
0
0
48
25
27.29
64.10
4.1
1.8
—
—
—
0
0
90
140
13.83
63.39
5.0
1.8
—
—
—
0
0
74
92
14.40
61.10
4.0
1.6
—
—
—
0
0
36
21
21.99
45.08
1.4
1.0
—
—
—
0
0
57
78
10.94
42.56
9.7
5.2
1.82
0.96
mmol/l
0.72
48
68
40
8
66.53
35.51
2.8
1.3
—
—
—
0
0
40
44
11.88
34.59
3.2
1.8
—
—
—
0
0
121
493
7.48
29.03
17.0
5.1
1.20
1.22
mmol/l
1.71
112
410
35
11
40.48
28.31
2.1
1.7
—
—
—
0
0
36
13
35.47
28.22
2.2
1.7
—
—
—
0
0
72
197
5.93
26.77
2.8
1.5
3.26
2.37
mg/l
2.27
64
166
27
5
64.72
23.93
2.4
2.8
465.35
832.00
e6/l
—
17
5
34
18
23.76
23.90
4.2
1.6
—
—
—
0
0
28
9
37.48
22.39
2.9
1.2
—
—
—
0
0
26
6
51.57
22.20
3.5
3.0
193.89
188.17
e6/l
—
18
6
39
74
6.69
20.92
2.5
1.3
—
—
—
0
0
27
35
9.12
20.21
1.4
1.6
1.69
1.45
g/l
0.42
22
30
28
38
8.76
20.21
1.6
1.2
—
—
—
0
0
29
16
21.94
20.02
1.9
1.4
—
—
—
0
0
31
50
7.49
19.29
3.0
1.6
—
—
—
0
0
44
102
5.62
19.03
15.7
5.2
102.39
104.98
mmol/l
2.49
44
102
54
152
4.90
18.58
4.4
2.2
488.94
125.04
ng/l
0.93
48
111
27
40
7.95
18.05
12.0
5.0
25.41
24.84
mmol/l
0.26
27
40
26
38
8.01
17.56
3.7
2.1
25.00
24.32
mmol/l
0.28
26
38
74
284
4.05
16.59
5.4
2.8
0.64
0.33
e6/l
0.32
61
193
87
381
3.90
15.94
5.3
2.8
—
—
—
0
0
92
422
3.88
15.65
3.1
1.8
80.18
80.46
nmol/l
0.03
85
362
22
13
19.46
14.80
2.7
1.2
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
25
21
13.94
14.71
2.8
2.6
0.26
0.27
iu/ml
—
10
9
24
19
14.70
14.48
1.8
1.9
—
—
—
0
0
24
40
6.91
14.33
2.0
1.5
18.24
4.32
ug/l
1.32
19
34
23
18
14.77
13.94
4.9
2.6
24.80
25.41
mmol/l
0.20
23
18
21
13
18.43
13.91
5.3
1.8
—
—
—
0
0
21
13
18.43
13.91
5.3
1.8
—
—
—
0
0
17
6
31.51
13.27
1.9
1.2
—
—
—
0
0
18
10
20.13
12.38
1.4
1.0
—
—
u/ml
—
0
0
48
163
3.81
12.35
5.4
2.6
0.70
1.24
e6/l
0.31
30
74
22
22
11.44
11.96
1.6
1.5
117.21
132.14
g/l
0.94
14
14
48
173
3.56
11.20
5.1
2.4
0.57
0.78
e6/l
0.33
29
84
16
9
19.61
10.98
4.6
1.2
—
—
—
0
0
16
9
19.61
10.98
4.6
1.2
—
—
—
0
0
16
9
19.61
10.98
4.6
1.2
—
—
—
0
0
86
444
3.09
10.93
2.5
1.6
95.70
99.92
pmol/l
0.44
58
232
75
359
3.10
10.89
5.0
2.1
33.16
19.94
ng/l
0.64
62
229
19
18
11.84
10.62
1.7
1.2
—
—
—
0
0
19
18
11.84
10.62
1.7
1.2
—
—
—
0
0
10
0
+∞
10.53
1.4
0.0
—
—
—
0
0
10
0
+∞
10.53
2.9
0.0
—
—
—
0
0
14
6
25.42
10.44
2.2
1.2
—
—
—
0
0
93
513
3.01
10.31
5.6
2.7
—
—
estimate
—
0
0
20
24
9.39
9.92
1.4
2.8
2.28
16.42
ratio
—
9
16
15
10
16.43
9.73
5.3
2.2
7.75
9.36
kpa
—
15
10
59
260
3.04
9.72
5.7
2.3
—
—
—
0
0
20
41
5.45
9.61
16.8
6.6
1.23
1.11
%
0.28
20
41
21
29
8.19
9.60
2.3
2.4
4.39
3.33
g/l
1.06
21
29
21
29
8.19
9.60
2.3
2.4
8.38
7.08
g/l
1.86
21
29
21
29
8.19
9.60
2.3
2.4
3.98
4.33
g/l
0.35
21
29
19
38
5.55
9.36
16.8
6.8
0.63
0.63
%
0.03
19
38
14
9
16.92
9.22
1.8
2.1
14.89
15.79
%
—
14
9
101
606
2.89
9.19
4.4
2.3
—
—
—
0
0
13
7
20.07
9.10
5.2
1.3
—
—
—
0
0
13
7
20.07
9.10
5.2
1.3
—
—
—
0
0
13
7
20.07
9.10
5.2
1.3
—
—
—
0
0
13
7
20.07
9.10
5.2
1.3
—
—
—
0
0
55
243
2.95
8.91
7.3
2.7
346.42
345.25
umol/l
0.03
48
218
19
41
5.14
8.61
17.2
6.6
94.04
95.14
%
0.42
19
41
56
258
2.83
8.32
4.6
1.5
109.39
181.76
u/l
1.64
51
246
19
29
7.30
8.19
2.4
2.4
3.48
2.81
g/l
1.55
19
29
37
137
3.23
8.06
1.6
1.5
1032.24
1176.49
nmol/l
0.47
28
100
11
6
19.56
7.72
5.8
1.3
—
—
—
0
0
11
6
19.56
7.72
5.7
1.3
—
—
—
0
0
11
6
19.56
7.72
5.7
1.3
—
—
—
0
0
41
169
2.93
7.39
1.6
1.5
409.66
65468071.14
pmol/l
0.50
35
139
16
24
7.30
7.02
6.3
2.2
356.13
124.48
ug/l
0.57
16
24
51
247
2.58
6.68
4.7
2.3
16.45
8.27
mg/mmol
0.43
35
126
90
571
2.36
6.41
5.2
2.6
0.00
0.00
estimate
-0.00
21
114
14
20
7.57
6.38
2.7
2.1
0.00
0.00
g/l
-0.00
14
20
9
5
18.97
6.34
3.3
2.2
—
—
—
0
0
90
580
2.30
6.07
5.2
2.6
0.00
0.00
estimate
-0.00
21
115
90
583
2.29
5.95
5.2
2.6
0.00
0.00
estimate
-0.00
21
118
29
111
2.98
5.88
5.3
2.3
—
—
—
0
0
14
23
6.57
5.84
2.7
2.6
0.07
0.00
g/l
0.47
14
23
15
28
5.81
5.70
2.7
2.5
1.11
3.25
g/l
0.79
15
28
14
24
6.30
5.68
2.4
1.5
—
—
—
0
0
13
21
6.65
5.51
2.2
1.3
—
—
—
0
0
12
18
7.12
5.37
1.5
1.2
311.00
215.70
u/ml
—
5
10
13
22
6.34
5.35
2.8
1.4
—
—
—
0
0
8
6
13.95
5.13
1.5
1.7
—
—
—
0
0
9
9
10.52
5.09
3.4
2.0
—
—
—
0
0
9
9
10.52
5.09
3.4
1.9
—
—
—
0
0
9
9
10.52
5.09
3.4
2.0
—
—
—
0
0
9
9
10.52
5.09
3.4
2.0
—
—
—
0
0
9
9
10.52
5.09
3.4
2.0
—
—
—
0
0
9
9
10.52
5.09
3.4
2.0
—
—
—
0
0
12
20
6.40
5.02
1.5
2.4
—
—
—
0
0
8
7
11.95
4.84
1.4
1.4
499.00
582.29
u/l
—
8
7
15
36
4.50
4.66
7.4
2.1
—
—
—
0
0
32
151
2.41
4.28
1.3
1.2
21.25
32.33
iu/ml
—
8
47
10
17
6.20
4.20
1.3
1.1
—
—
—
0
0
22
87
2.78
4.18
3.2
2.7
0.08
0.22
e6/l
0.68
22
80
13
31
4.48
4.12
4.1
2.0
—
—
—
0
0
106
797
2.03
4.08
3.6
3.1
15.09
14.79
pmol/l
0.54
97
723
7
8
9.09
3.81
1.7
2.9
-1.16
3.51
mmol/l
—
7
8
6
5
12.40
3.79
1.0
2.0
11.50
9.00
u/l
—
6
5
28
133
2.35
3.67
1.3
1.2
1.20
7.34
u/ml
0.49
12
47
32
162
2.23
3.63
1.3
1.1
1.14
0.60
u/ml
0.97
12
49
7
10
7.27
3.40
2.6
1.6
10.31
8.90
mmol/l
—
7
10
8
16
5.21
3.09
1.1
1.1
—
—
—
0
0
5
5
10.27
3.00
1.2
2.2
105.40
135.60
%
—
5
5
5
6
8.55
2.77
1.4
1.2
—
—
—
0
0
64
450
1.72
2.68
4.4
2.4
0.00
0.00
estimate
-0.00
19
90
49
320
1.77
2.65
4.2
2.1
0.00
0.00
estimate
-0.00
19
90
11
36
3.21
2.62
4.7
1.6
1.02
0.66
%
0.42
11
36
141
1249
2.34
2.61
64.2
11.2
138.67
140.05
mmol/l
7.46
141
1215
18
83
2.32
2.52
6.7
2.6
44.91
71.33
ml/min/173m2
2.80
11
32
141
1253
2.30
2.52
65.7
11.4
4.05
3.97
mmol/l
3.52
141
1215
8
21
3.96
2.50
1.0
1.7
11.39
18.12
ug/l
—
8
21
37
243
1.69
1.92
4.6
2.7
1.02
1.02
kg/l
1.59
30
139
140
1286
1.86
1.57
37.6
8.4
23.80
24.88
u/l
0.60
140
1229
118
1041
1.55
1.53
4.8
3.7
1.84
2.20
mu/l
1.21
107
932
45
328
1.52
1.51
5.1
2.7
0.00
0.00
estimate
-0.00
20
111
141
1308
1.81
1.38
70.5
13.5
84.14
78.43
umol/l
0.91
141
1285
5
17
3.00
1.37
1.2
1.4
4.70
13.24
pmol/l
—
5
17
112
988
1.47
1.36
73.4
13.6
325.64
333.76
g/l
11.26
112
981
22
139
1.68
1.32
1.3
1.3
—
—
—
0
0
6
24
2.56
1.31
1.0
1.3
—
—
—
0
0
110
1192
0.74
0.91
4.8
4.3
1.47
1.51
mmol/l
0.32
101
1095
141
1340
1.54
0.82
84.9
15.3
4.16
4.56
e12/l
12.07
141
1294
141
1340
1.54
0.82
87.0
15.4
37.75
41.14
%
12.65
141
1311
141
1340
1.54
0.82
84.7
15.3
91.57
91.29
fl
0.23
141
1313
141
1340
1.54
0.82
85.4
15.3
279.45
241.73
e9/l
4.05
141
1299
0
24
0.00
0.80
0.0
1.1
—
—
—
0
0
141
1342
1.53
0.79
85.5
15.4
122.56
138.61
g/l
22.09
141
1313
5
27
1.88
0.69
1.8
1.9
29.00
41.48
nmol/l
—
5
27
5
27
1.88
0.69
1.2
1.1
—
—
—
0
0
113
1198
0.79
0.58
4.7
4.3
4.58
4.90
mmol/l
2.58
104
1103
9
63
1.45
0.53
1.7
1.8
—
—
—
0
0
45
511
0.83
0.44
2.1
1.7
1.31
1.24
mmol/l
0.34
37
432
8
57
1.42
0.43
1.5
1.7
—
—
—
0
0
72
658
1.17
0.42
5.2
6.0
1.59
4.09
ug/l
1.13
61
594
0
16
0.00
0.41
0.0
1.1
—
46.16
—
0
8
0
16
0.00
0.41
0.0
1.0
—
531.13
—
0
8
116
1211
0.84
0.39
5.2
4.8
2.63
2.97
mmol/l
3.43
106
1107
6
47
1.29
0.32
2.5
1.5
43.17
8.26
mg/l
—
6
36
120
1162
1.14
0.25
5.4
4.0
5.94
5.59
mmol/l
1.55
113
1049
40
439
0.88
0.25
3.7
3.3
0.64
0.75
ug/l
0.64
26
307
5
41
1.23
0.22
2.0
1.2
—
—
—
0
0
53
568
0.90
0.22
3.8
4.9
22.74
20.05
%
0.53
22
319
109
1122
0.91
0.18
4.3
3.6
1.34
1.20
mmol/l
1.23
102
1022
14
119
1.19
0.18
1.6
1.5
—
—
—
0
0
109
1117
0.92
0.14
6.2
3.8
40.59
36.58
mmol/mol
4.42
103
1020
12
128
0.93
0.02
8.7
4.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
66.67
—
0
6
0
8
0.00
-0.00
0.0
4.9
—
236.13
—
0
8
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint ABPA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ABPA | 3.293 [2.26, 4.8] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.603 |
During the follow-up period (1.1.1998 — 31.12.2019), 68 out of 184 females with ABPA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ABPA | 4.575 [3.14, 6.67] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.071 |
During the follow-up period (1.1.1998 — 31.12.2019), 146 out of 299 males with ABPA died.
Mortality risk
Mortality risk for people of age
years, who have ABPA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.361% | 0.785% |
| 5 | 2.115% | 5.488% |
| 10 | 5.29% | 13.321% |
| 15 | 10.035% | 24.056% |
| 20 | 16.778% | 38.985% |
Relationships between endpoints
↥Index endpoint: ABPA – Allergic bronchopulmonary aspergillosis (ABPA)
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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