Yaws, including avohilmo

AB1_YAWNS_WIDE

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Primary healthcare outpatient: ICD-10 — A66 Hospital discharge: ICD-10 — A66 Cause of death: ICD-10 — A66 3 out of 7 registries used, show all original rules.	167
4. Check minimum number of events None	167
5. Include endpoints None	167
6. Filter based on genotype QC (FinnGen only)	146

Control definitions (FinnGen only)

Control exclude: AB1_OTHER_SPIROCHAETAL

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF13

NAME	AB1_YAWNS_WIDE
CONTROL_EXCLUDE	AB1_OTHER_SPIROCHAETAL
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD	A66
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	A66
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	A66
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Yaws, including avohilmo based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	146	84	62
Unadjusted period prevalence (%)	0.03	0.03	0.03
Median age at first event (years)	55.67	51.78	60.93

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
154: Matched controls
1540

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

A66.1

ICD-10 Finland

Multiple papillomata and wet crab yaws

+∞

66.6

A66.3

ICD-10 Finland

Hyperkeratosis of yaws

+∞

30.2

A66.2

ICD-10 Finland

Other early skin lesions of yaws

+∞

24.6

A66.9

ICD-10 Finland

Yaws, unspecified

+∞

15.9

A66

ICD-10 Finland

Yaws

+∞

10.5

A66.0

ICD-10 Finland

Initial lesions of yaws

+∞

9.5

A69.2

ICD-10 Finland

Lyme disease

+∞

8.4

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(40768804) Tissue Pathology biopsy report

511

2.48

7.09

2.6

2.0

—

(3033658) Prothrombin time (PT) actual/Normal

308

2.22

5.02

4.1

3.7

91.62

91.45

0.02

303

(3049717) Cytology report of Urine Cyto stain

3.53

3.10

3.6

2.7

—

(4035726) Immunohistochemistry procedure

103

2.33

2.98

1.3

1.4

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

290

1.84

2.82

2.1

2.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

113

929

1.81

2.69

3.5

3.4

—

(46236952) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)/1.73 sq M

103

2.20

2.56

2.1

2.3

75.62

71.23

ml/min/173m2

0.20

(3014051) Protein [Presence] in Urine by Test strip

384

1.67

2.31

2.8

2.6

—

0.18

—

(3031040) Bacteria [#/volume] in Urine by Automated count

105

864

1.68

2.30

4.6

3.8

—

26.69

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

145

1331

2.53

2.29

15.8

14.2

25.29

21.66

mg/l

0.57

120

1084

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

539

1.59

2.09

2.6

1.9

88.76

93.74

pmol/l

0.49

288

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

563

1.56

1.98

3.1

2.5

73.39

73.23

nmol/l

0.02

506

(3044640) Blood type and Crossmatch panel - Blood

399

1.59

1.94

2.3

2.4

—

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

139

1260

2.06

1.93

15.9

13.8

85.17

85.60

ml/min/173m2

0.08

123

1153

(3024561) Albumin [Mass/volume] in Serum or Plasma

547

1.51

1.73

5.4

4.4

36.80

36.40

g/l

0.21

525

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

196

1.66

1.58

1.8

1.9

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

134

1221

1.75

1.53

6.7

6.0

38.43

38.79

mmol/mol

0.21

128

1159

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

142

1.73

1.49

1.7

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

2.39

1.45

1.6

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

184

1.64

1.45

4.0

2.7

7.56

2.49

e6/l

0.70

101

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

3.19

1.45

1.0

1.5

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

3.19

1.45

1.0

1.5

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

3.19

1.45

1.0

1.5

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

331

1.51

1.45

2.1

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

142

1322

1.95

1.42

5.9

5.5

2.76

2.75

mmol/l

0.05

135

1244

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

574

1.44

1.41

2.0

1.9

1.51

1.42

mmol/l

0.40

493

(3030467) Casts [#/volume] in Urine by Automated count

360

1.48

1.40

3.9

2.9

0.18

0.45

e6/l

1.39

273

(3043238) Trisomy 21 risk [Likelihood] in Fetus

2.27

1.39

1.7

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

774

1.43

1.35

10.9

10.3

4.70

4.10

e9/l

0.89

681

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

134

1233

1.67

1.32

5.5

5.3

1.81

1.94

mu/l

0.69

123

1151

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.82

1.31

1.1

1.5

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

173

1.61

1.29

1.9

2.0

3.82

3.54

ratio

0.62

135

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

147

1396

2.17

1.28

13.6

11.1

25.63

26.16

u/l

0.18

142

1371

(3000494) Fungus identified in Specimen by Culture

157

1.63

1.27

1.3

1.6

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

140

1306

1.79

1.26

5.2

4.9

4.65

mmol/l

0.01

131

1234

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

234

1.52

1.25

4.3

3.6

19.65

251.59

ng/l

1.08

166

(3022096) Basophils/Leukocytes in Blood

642

1.40

1.25

7.4

6.1

0.65

0.67

0.17

606

(3018010) Neutrophils/Leukocytes in Blood

652

1.40

1.24

6.9

5.9

56.84

57.84

0.35

624

(4195642) Thrombophilia screening test

2.68

1.22

1.4

1.2

—

(3002030) Lymphocytes/Leukocytes in Blood

664

1.39

1.21

6.9

5.9

29.66

27.67

0.90

635

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.16

1.20

1.0

1.2

—

(3002256) Pathology report gross observation

168

1.58

1.19

1.6

1.3

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

103

1.73

1.18

3.8

2.3

0.21

0.22

g/l

0.14

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

139

1299

1.72

1.18

5.0

4.8

1.43

1.45

mmol/l

0.28

130

1223

(3010421) pH of Blood

0.00

1.15

0.0

3.8

—

7.41

—

(3018095) Leukocytes [#/volume] in Urine

496

1.38

1.12

4.3

3.4

68.27

95.14

e6/l

0.18

356

(3032080) INR in Blood by Coagulation assay

573

1.37

1.11

14.1

11.7

1.28

1.19

inr

0.60

471

(40761536) Microorganisms panel - Urine sediment

121

0.48

1.11

5.3

3.1

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

141

1328

1.73

1.08

18.8

16.4

3.95

3.96

mmol/l

0.22

136

1300

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

2.06

1.07

1.6

—

(3009508) Creatinine [Moles/volume] in Urine

452

1.38

1.07

3.8

3.3

7.65

8.26

mmol/l

0.44

390

(3006504) Eosinophils/Leukocytes in Blood

644

1.36

1.07

7.1

5.9

3.23

2.81

0.64

610

(3002582) Erythrocytes [#/volume] in Urine

416

1.38

1.04

4.0

3.0

15.68

57.29

e6/l

1.70

330

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

2.11

1.04

1.3

1.2

—

(3019069) Monocytes/Leukocytes in Blood

647

1.34

1.02

7.5

6.1

8.11

8.58

1.05

615

(3029937) Albumin [Presence] in Urine by Test strip

410

0.69

1.01

5.1

3.6

0.00

estimate

—

154

(3013115) Eosinophils [#/volume] in Blood

727

1.34

1.01

7.8

6.3

0.22

0.19

e9/l

0.46

638

(3051387) C reactive protein [Mass/volume] in Capillary blood

0.00

0.98

0.0

4.8

—

28.55

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.78

0.94

2.2

2.0

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

161

1.50

0.93

3.3

8.6

104.57

104.55

mmol/l

0.00

161

(42868678) Cholesterol non HDL [Moles/volume] in Serum or Plasma

128

1.55

0.91

1.7

1.8

3.54

3.57

mmol/l

0.05

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

112

1.58

0.89

1.4

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

251

1.40

0.88

1.5

1.3

12.91

33.12

iu/ml

1.72

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.82

0.85

1.5

2.1

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.82

0.85

1.6

2.3

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

1.97

0.85

1.3

1.4

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

601

1.30

0.85

3.1

2.8

—

estimate

—

(3019198) Lymphocytes [#/volume] in Blood

720

1.30

0.84

6.7

6.0

1.98

1.92

e9/l

0.18

642

(3024928) Oxygen saturation in Venous blood

1.91

0.82

4.7

3.3

67.30

57.51

—

(3026008) Bacteria identified in Urine by Culture

346

1.34

0.82

3.9

2.5

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.77

0.82

1.3

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

319

1.34

0.81

3.2

2.0

2.20

2.81

mg/l

1.48

278

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

106

966

1.31

0.80

4.0

3.3

43.22

42.34

u/l

0.05

101

924

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.80

0.0

3.4

—

8.57

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.80

0.0

3.4

—

5.13

—

(3012501) Base excess in Blood by calculation

0.00

0.80

0.0

3.4

—

2.69

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

1.59

0.78

6.6

2.3

5.08

5.19

kpa

0.20

(3005322) IgE [Units/volume] in Serum or Plasma

100

1.55

0.76

1.2

1.3

254.05

590.14

u/ml

0.61

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

2.12

0.75

1.0

1.1

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

1.88

0.74

1.0

1.4

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.83

0.73

1.0

1.2

—

(40758558) Short blood count panel - Blood

418

1.29

0.72

9.1

5.8

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

1.61

0.72

1.0

1.1

1.54

1.59

g/l

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.68

0.70

1.1

1.5

—

(4034850) Laboratory test

1.70

0.69

4.7

11.7

—

(3020682) Albumin/Creatinine [Ratio] in Urine

411

1.28

0.69

4.8

4.2

10.56

12.37

mg/mmol

0.12

265

(3019225) pH of Specimen

103

1.51

0.68

2.7

3.7

7.39

7.34

—

(40768443) Skin Pathology biopsy report

1.66

0.67

1.1

1.2

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

347

1.29

0.66

3.7

3.3

1310.14

859.30

ng/l

0.35

288

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

138

1.43

0.66

2.0

1.8

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

130

1231

1.36

0.66

4.5

4.1

1.42

1.29

mmol/l

0.95

123

1150

(3000764) Benzodiazepines [Presence] in Urine

1.54

0.65

1.4

1.5

—

(3027008) Opiates [Presence] in Urine

1.52

0.63

1.4

—

(42870588) Differential panel, method unspecified - Blood

435

1.26

0.62

7.4

5.4

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

1.69

0.62

1.2

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

1.69

0.62

1.8

1.2

—

(3019230) Fractional oxyhemoglobin in Venous blood

1.69

0.62

1.8

2.3

66.00

57.34

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

258

1.30

0.60

1.8

1.7

—

(3027944) Amphetamines [Presence] in Urine

1.50

0.60

1.4

1.5

—

(3028300) Cannabinoids [Presence] in Urine

1.50

0.60

1.4

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

141

1.40

0.60

2.4

1.8

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.59

0.0

2.8

—

18.46

—

(3012516) Albumin [Mass/volume] in Urine

400

1.25

0.58

4.4

3.5

62.28

74.76

mg/l

0.15

277

(3001604) Monocytes [#/volume] in Blood

702

1.23

0.58

6.5

5.8

0.57

e9/l

0.04

607

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

232

1.31

0.58

1.5

1.3

1.22

11.90

u/ml

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

316

1.27

0.57

4.3

4.5

26.72

21.26

0.69

150

(3021879) Hepatitis B virus core Ab [Presence] in Serum

125

1.40

0.56

1.4

1.5

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

1.56

0.56

1.0

1.2

1.01

0.88

g/l

—

(3019832) Treponema pallidum Ab [Presence] in Serum

188

1.33

0.55

2.2

1.8

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

606

1.22

0.55

7.9

7.4

1.22

1.21

mmol/l

0.43

526

(3019150) Specific gravity of Urine by Refractometry

318

1.26

0.54

3.3

3.4

1.02

kg/l

0.48

208

(3006315) Basophils [#/volume] in Blood

706

1.21

0.54

6.5

5.9

0.04

e9/l

0.76

609

(3007853) Bacteria identified in Skin by Aerobe culture

153

1.35

0.53

1.8

1.6

—

(40768797) Stomach Pathology biopsy report

162

1.34

0.53

1.4

1.2

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

1.52

0.52

1.0

1.3

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.52

0.52

1.3

1.2

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

1.52

0.52

1.0

1.2

—

(3018418) pH of Serum or Plasma

377

1.23

0.51

4.9

3.7

7.40

0.47

273

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

106

0.64

0.50

3.3

4.3

1.23

mmol/l

—

(3003191) Choriogonadotropin [Presence] in Serum or Plasma

1.55

0.49

1.1

2.1

—

(3015736) pH of Urine

563

1.20

0.48

3.0

3.2

6.11

6.16

0.12

335

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

111

1046

1.22

0.48

4.5

4.4

14.30

14.66

pmol/l

0.74

103

969

(1002224) Polysomnography panel

0.59

0.47

1.2

1.0

—

(3019977) pH of Arterial blood

130

1.35

0.46

2.6

13.1

7.42

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

205

1.26

0.43

4.1

2.6

1.22

0.98

e6/l

0.13

121

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.58

0.42

1.8

1.9

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

1.58

0.42

1.8

1.2

—

(3036489) Thrombin time

1.38

0.41

5.3

1.9

20.00

22.53

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

0.41

0.0

1.5

—

43.00

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

124

1.32

0.40

3.1

2.3

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

292

1.21

0.39

2.5

1.8

0.66

1.43

mg/l

1.76

241

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.39

0.0

2.9

—

1.18

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.39

0.0

2.9

—

105.00

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.39

0.0

2.9

—

4.05

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

1.36

0.39

1.4

1.6

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

1.34

0.38

2.3

13.0

24.66

24.38

mmol/l

—

(3000492) Spirometry study

144

0.75

0.35

1.4

1.5

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

1.38

0.35

14.8

2.2

132.17

185.82

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.38

0.35

1.7

1.5

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.38

0.35

2.0

2.3

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

1.35

0.34

1.2

1.5

—

(3042936) Bacteria identified in Isolate by Culture

183

1.24

0.34

1.8

2.3

—

(3030366) Cystatin C [Mass/volume] in Serum or Plasma

1.32

0.33

7.2

4.3

1.39

1.41

mg/l

—

(1761868) Lipid panel - Serum or Plasma

570

1.15

0.32

2.7

2.9

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.34

0.31

1.7

2.2

—

(3016879) Cocaine [Presence] in Urine

1.33

0.31

1.4

—

(3009261) Glucose [Presence] in Urine by Test strip

730

1.14

0.31

4.1

3.5

0.00

estimate

—

152

(3003327) Ova and parasites identified in Stool by Light microscopy

1.29

0.30

2.7

1.6

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

234

1.19

0.29

2.8

3.0

0.95

0.77

ug/l

0.29

138

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.32

0.29

4.4

9.0

25.36

25.26

mmol/l

0.03

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

1.34

0.29

4.3

3.0

23.92

24.51

mmol/l

—

(3023368) Bacteria identified in Blood by Culture

340

1.16

0.28

3.9

4.2

—

(3019060) Gas panel - Arterial blood

1.24

0.27

2.3

11.6

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

189

1.19

0.26

2.0

1.5

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

450

1.13

0.25

3.1

2.9

2.37

2.35

mmol/l

0.59

420

(3001019) Free T4 and TSH panel - Serum or Plasma

1.20

0.25

1.6

1.9

—

(3022145) Colonoscopy Study observation

152

1.21

0.25

1.1

1.3

—

(40760892) CBC W Ordered Manual Differential panel - Blood

346

0.87

0.24

2.9

4.5

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

248

1.16

0.24

2.8

2.3

—

(3007566) Smooth muscle Ab [Titer] in Serum

1.36

0.24

1.6

1.2

—

93.33

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.26

0.22

1.0

1.2

—

(3023511) Choriogonadotropin [Units/volume] in Urine

1.23

0.22

1.2

1.4

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.21

0.0

1.0

—

(4027681) Cerebrospinal fluid IgG ratio and IgG index

0.00

0.21

0.0

1.2

—

0.46

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.21

0.0

1.1

—

8.12

—

(3003434) Protein [Mass/volume] in Pleural fluid

0.00

0.21

0.0

2.1

—

36.60

—

(3045788) Cell count panel - Pleural fluid

0.00

0.21

0.0

1.7

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.21

0.0

4.4

—

0.80

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.21

0.0

1.3

—

296.20

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.21

0.0

1.0

—

(3024474) Albumin [Mass/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

234.08

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

0.21

0.0

1.2

—

(44806420) Estimation of glomerular filtration rate

0.00

0.21

0.0

2.2

—

(3032700) Glomerular basement membrane Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

0.21

0.0

1.7

—

5.49

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.5

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.20

0.0

4.3

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.20

0.0

2.4

—

90.80

—

(3003694) ABO and Rh group [Type] in Blood

407

1.11

0.20

1.8

1.5

—

(3050129) First trimester maternal screen panel - Serum or Plasma

1.21

0.20

1.3

1.4

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

1.18

0.19

6.5

1.9

115.83

88.43

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

233

1.14

0.19

2.2

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

253

1.13

0.18

2.0

1.7

344.79

454.96

pmol/l

2.66

223

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

234

1.13

0.18

1.4

1.6

—

(36660697) Celiac disease serology panel - Serum

129

1.18

0.17

1.0

1.2

—

(3037522) Nuclear Ab [Titer] in Serum

196

1.14

0.17

1.5

1.4

793.33

531.20

titre

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.17

0.17

1.6

1.9

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.15

0.16

1.1

1.2

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

130

0.83

0.16

2.9

3.5

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.13

0.15

1.4

1.2

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.10

0.15

1.4

—

(3035350) Ketones [Presence] in Urine by Test strip

723

1.07

0.13

4.2

3.5

0.00

estimate

—

167

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

148

0.87

0.13

4.5

31.29

30.41

—

(3041096) Erythrocytes [Presence] in Urine by Automated

428

1.07

0.11

3.8

3.0

0.00

estimate

—

132

(3025941) Bacteria identified in Stool by Culture

1.17

0.11

1.2

1.3

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

222

1.10

0.11

4.3

3.7

0.84

0.82

mmol/l

0.37

213

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.17

0.10

1.0

1.3

—

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

1.17

0.10

1.4

1.1

—

20.96

—

(3028707) Methadone [Presence] in Urine by Screen method

1.14

0.10

1.4

1.7

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

204

1.09

0.09

1.5

1.6

—

(3011288) Drugs identified in Urine by Screen method Nominal

1.09

0.09

1.7

1.9

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

368

0.94

0.09

1.4

1.3

7.40

2.22

u/ml

—

104

(3000991) Gas panel - Venous blood

113

0.88

0.08

4.5

9.7

—

(3022313) Gas panel - Capillary blood

0.83

0.08

2.6

2.2

—

(3008898) HLA-B27 [Presence]

0.81

0.08

1.0

1.1

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

314

1.06

0.07

1.8

1.7

—

(3028026) IgM [Mass/volume] in Serum or Plasma

1.05

0.07

1.6

1.7

0.97

1.24

g/l

—

(3013512) EKG study

424

1.05

0.07

3.6

3.2

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

495

0.96

0.06

3.0

3.8

1513.04

156.41

ng/l

0.44

327

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

127

1257

1.06

0.05

5.7

4.8

5.90

5.88

mmol/l

0.11

121

1167

(40761511) CBC panel - Blood by Automated count

137

1381

0.93

0.05

12.8

12.6

—

(3021601) Nitrite [Presence] in Urine by Test strip

716

1.04

0.05

4.3

3.5

0.00

estimate

—

167

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

557

1.04

0.04

3.8

3.4

0.00

0.01

estimate

—

138

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

136

0.95

0.00

3.4

6.8

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

106

1.04

0.00

3.7

2.2

—

(3022621) pH of Urine by Test strip

119

1.01

0.00

2.4

1.8

6.14

6.02

—

(3007164) IgA [Mass/volume] in Serum or Plasma

335

1.02

0.00

1.3

1.4

3.07

2.31

g/l

0.50

201

(21494755) Public health laboratory ask at order entry panel

165

1.03

0.00

1.5

1.4

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

128

1.02

0.00

1.2

64.50

125.17

u/ml

—

(3021589) Normoblasts [#/volume] in Blood

631

1.00

0.00

10.6

11.1

0.00

e9/l

0.43

516

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.0

1.8

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

1.7

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

2.0

—

9.48

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.2

—

(3041806) Other cells [#/volume] in Blood by Manual count

0.00

0.0

1.0

—

0.42

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

5.6

—

205.50

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(3040370) OLANZapine [Moles/volume] in Serum or Plasma

0.00

0.0

2.7

—

134.17

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

5.5

—

10.37

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.4

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

5.5

—

4.53

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.4

—

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

1.5

—

3.46

—

(3020911) Cortisol [Moles/time] in 24 hour Urine

0.00

0.0

1.0

—

52.00

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.4

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.2

—

(3036432) Mycobacterium tuberculosis genotype [Identifier] in Isolate

0.00

0.0

10.2

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

1.9

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

-0.00

0.0

2.7

—

(3020650) Glucose [Presence] in Urine

0.00

-0.00

0.0

1.0

—

0.00

—

(3009306) Alpha-1-Fetoprotein [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.6

—

3.98

—

(42868766) Dientamoeba fragilis DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3012544) pH of Venous blood

130

1.00

-0.00

8.5

3.8

7.37

7.38

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

0.93

-0.00

1.9

3.3

0.41

0.59

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.96

-0.00

1.1

1.0

—

(40757494) Bilirubin.total [Moles/volume] in Blood

0.00

-0.00

0.0

1.6

—

(40758292) HTLV I+II Ab panel - Serum

0.00

-0.00

0.0

1.4

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.1

—

(3033306) Mononuclear cells/Leukocytes in Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

(3036428) Adenosine deaminase [Enzymatic activity/volume] in Pleural fluid

0.00

-0.00

0.0

1.1

—

10.29

—

(3043410) Blood group antigens tested for on Red Blood Cells

0.00

-0.00

0.0

1.0

—

(4198724) Urine methamphetamine measurement

0.00

-0.00

0.0

1.8

—

(3017569) Oxygen content in Arterial blood

0.00

-0.00

0.0

2.2

—

15.48

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

-0.00

0.0

1.1

—

(3020891) Body temperature

1.00

-0.00

1.7

5.0

36.93

36.95

°c

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

-0.00

0.0

1.1

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

-0.00

0.0

1.0

—

(3018658) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.1

—

(3052649) Adenosine deaminase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

12.43

—

(43055246) Days in therapeutic INR range/Days INR result determined [Ratio]

0.00

-0.00

0.0

3.8

—

71.60

—

(44817194) Complement alternate pathway AH50 actual/normal in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

90.40

—

(44813793) Dust mix specific IgE antibody measurement

0.00

-0.00

0.0

1.2

—

Mortality – FinRegistry

↥

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

↥

Index endpoint: AB1_YAWNS_WIDE – Yaws, including avohilmo

GWS hits: 1

This endpoint is excluded (different definition than used in FinnGen).

≡ Risteys

R14

FinnGen R13 + FinRegistry

FinnGen R12 + FinRegistry

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Yaws, including avohilmo

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Yaws, including avohilmo (AB1_YAWNS_WIDE)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Relationships between endpoints