Typhoid and paratyphoid fevers, including avohilmo

AB1_TYPHOIDPARATHYPHOID_WIDE

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Primary healthcare outpatient: ICD-10 A01
  • Hospital discharge: ICD-10 A01
  • Hospital discharge: ICD-9 002.
  • Hospital discharge: ICD-8 00[1-2]
  • Cause of death: ICD-10 A01
  • Cause of death: ICD-9 002.
  • Cause of death: ICD-8 00[1-2]

3 out of 7 registries used, show all original rules.

264

4. Check minimum number of events

None

264

5. Include endpoints

None

264

6. Filter based on genotype QC (FinnGen only)

231

Control definitions (FinnGen only)

Control exclude
AB1_INTESTINAL_INFECTIONS

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF13

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 231 148 83
Unadjusted period prevalence (%) 0.05 0.05 0.04
Median age at first event (years) 44.74 42.79 48.22

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
246
Matched controls
2460
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A01
ICD-10 Finland
Typhoid and paratyphoid fevers
+∞
59.9
55
*
A01.0
ICD-10 Finland
Typhoid fever
+∞
38.6
36
*
00210
ICD-8 Finland
Paratyphoid fever B
+∞
29.8
28
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
4.4
18.9
55
150
A01.4
ICD-10 Finland
Paratyphoid fever, unspecified
+∞
17.9
17
*
SPAT1336
SPAT
Request for examination
5.9
13.4
25
46
00299
ICD-8 Finland
Paratyphoid fever unspecified
+∞
12.6
12
*
I39.8*A01.0
ICD-10 Finland
Endocarditis in typhoid fever
+∞
11.5
11
*
M01.3*A01.4
ICD-10 Finland
Arthritis in typhoid or paratyphoid fever
+∞
11.5
11
*
A60
ICPC
General and Unspecified, Result test/procedure
4.9
10.8
25
56
R05
ICPC
Cough
2.5
9.7
83
418
A98
ICD-10 Finland
Other viral haemorrhagic fevers, not elsewhere classified
15.9
9.6
15
10
L28
ICPC
Limited function/disability (L)
2.6
9.5
67
307
00199
ICD-8 Finland
Typhoid fever, Unspecified
+∞
9.4
9
*
EB1AA, ,
SPAT
3.8
9.3
30
87
Z2221
NOMESCO Finland
Medical doctor
2.4
8.8
86
456
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.8
8.7
49
200
R4110
NOMESCO Finland
Physiotherapy
2.3
8.6
84
446
A01.1
ICD-10 Finland
Paratyphoid fever A
+∞
8.4
8
*
R50.9
ICD-10 Finland
Fever, unspecified
2.7
7.9
49
210
N02AX02
ATC
tramadol; systemic, rectal
2.1
7.7
119
752
SPAT1342
SPAT
Referral to specialised care
13.9
7.5
12
9
0029X
ICD-9 Finland
Typhoid and paratyphoid fevers, Paratyphoid fever, unspecified
+∞
7.3
7
*
00220
ICD-8 Finland
Paratyphoid fever C
+∞
7.3
7
*
0022A
ICD-9 Finland
Typhoid and paratyphoid fevers, Paratyphoid fever B
+∞
7.3
7
*
0020A
ICD-9 Finland
Typhoid and paratyphoid fevers, Typhoid fever
+∞
7.3
7
*
M54.8
ICD-10 Finland
Other dorsalgia
4.0
7.2
21
56
J01MA02
ATC
ciprofloxacin; systemic
2.1
7.0
104
642
A01
ICPC
Pain general/multiple sites
2.7
6.9
39
159
Z3231
NOMESCO Finland
Registered nurse
2.2
6.8
77
429
T45
ICPC
Metabolic, Observ/health educat/advice/diet
14.8
6.5
10
7
N03AX16
ATC
[U] pregabalin
2.2
6.4
67
361
L02
ICPC
Back symptom/complaint
2.6
6.4
39
165
A02.1
ICD-10 Finland
Salmonella sepsis
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
74
332
2.76
11.14
3.6
2.9
4.01
3.38
e6/l
0.08
19
153
113
709
2.10
7.40
6.6
5.1
—
—
—
0
0
72
404
2.11
6.15
4.4
3.6
1313.37
254.82
ng/l
0.41
52
315
136
958
1.94
6.04
6.8
5.4
1.20
1.21
mmol/l
1.49
128
890
147
1063
1.95
6.04
8.2
6.0
1.20
1.21
mmol/l
0.94
139
912
141
1009
1.93
5.94
8.3
5.6
0.65
0.68
%
0.29
135
946
162
1217
1.97
5.87
11.7
9.8
3.83
4.01
e9/l
0.45
133
1073
88
543
1.97
5.73
5.1
4.0
—
—
—
0
0
51
260
2.21
5.50
2.8
2.5
112.91
98.54
ug/g
0.19
42
206
53
279
2.15
5.27
8.8
5.9
104.43
104.05
mmol/l
0.23
53
279
41
196
2.31
5.13
3.6
3.0
7.38
7.39
ph
0.18
26
116
54
290
2.10
5.09
2.5
1.9
—
—
—
0
0
36
167
2.35
4.82
1.2
1.2
—
—
—
0
0
146
1103
1.80
4.74
8.4
5.7
0.57
0.57
e9/l
0.02
116
945
146
1104
1.79
4.72
8.4
5.7
0.04
0.04
e9/l
0.40
115
946
148
1129
1.78
4.59
8.4
5.7
1.94
1.99
e9/l
0.14
118
992
150
1150
1.78
4.56
6.2
6.0
10.55
11.38
umol/l
0.82
143
1092
126
924
1.75
4.43
2.3
2.1
94.41
96.84
pmol/l
0.23
71
500
15
45
3.48
4.40
2.0
3.2
8.83
1.46
index
—
6
28
95
644
1.77
4.38
4.4
2.9
—
—
—
0
0
97
662
1.77
4.37
3.5
3.7
7.40
7.40
ph
0.58
56
478
132
984
1.74
4.35
10.3
10.9
0.00
0.00
e9/l
1.10
89
805
124
916
1.71
4.16
4.2
3.4
6.33
6.17
ph
0.82
66
520
147
1140
1.72
4.11
8.8
6.0
0.18
0.18
e9/l
0.01
118
995
14
36
4.06
4.07
1.2
1.1
—
—
—
0
0
134
1021
1.69
3.93
3.3
3.1
130.53
108.07
ug/l
0.24
126
960
76
496
1.77
3.93
1.3
1.3
0.58
1.43
u/ml
1.67
14
140
20
77
2.74
3.91
3.5
3.5
0.84
0.93
%
0.60
20
70
156
1239
1.71
3.91
7.0
4.3
6.37
6.54
mmol/l
0.52
148
1159
112
821
1.67
3.76
5.6
3.7
73.57
105.15
e6/l
0.28
67
562
191
1614
1.82
3.75
9.3
7.6
78.32
79.00
u/l
0.09
185
1532
28
130
2.30
3.75
1.3
1.2
—
—
—
0
0
41
222
2.02
3.74
10.4
6.9
7.43
7.42
ph
0.92
19
134
41
222
2.02
3.74
10.4
6.8
5.13
5.17
kpa
0.11
41
215
41
222
2.02
3.74
10.4
6.8
11.58
12.43
kpa
0.71
41
215
88
606
1.70
3.73
4.2
2.9
0.14
0.44
e6/l
2.49
55
440
34
175
2.09
3.55
12.0
7.6
—
—
—
0
0
94
667
1.66
3.53
7.5
6.2
—
—
—
0
0
37
199
2.01
3.44
10.9
7.3
96.41
95.41
%
0.75
37
194
95
681
1.64
3.40
3.7
2.2
—
—
—
0
0
8
15
5.47
3.21
1.5
2.3
13.26
10.95
%
—
8
15
90
644
1.63
3.21
1.6
1.6
20.06
21.16
nmol/l
0.35
85
544
20
87
2.41
3.10
3.6
3.4
1.72
1.51
%
0.53
20
81
25
121
2.19
3.05
3.8
3.1
24.57
24.56
mmol/l
0.01
25
121
41
240
1.85
2.98
2.1
1.5
—
—
—
0
0
14
52
2.79
2.94
6.9
4.3
—
—
—
0
0
96
710
1.58
2.94
4.3
3.1
18.91
149.78
e6/l
0.80
63
538
18
77
2.44
2.89
1.6
1.6
19.89
21.41
s
0.82
18
69
67
463
1.61
2.69
1.4
1.3
2.04
2.48
g/l
1.28
33
301
60
407
1.63
2.59
1.5
1.3
8.87
11.00
u/ml
0.12
19
157
70
495
1.58
2.55
2.0
1.7
0.98
1.21
mg/l
0.41
57
402
111
873
1.49
2.46
2.7
2.1
—
—
—
0
0
22
111
2.08
2.44
1.3
1.2
—
—
—
0
0
64
450
1.57
2.37
1.6
1.3
36.69
26.09
iu/ml
0.16
12
135
196
1743
1.61
2.36
29.2
19.1
331.79
331.98
g/l
0.10
196
1737
48
316
1.64
2.32
1.6
1.4
292.00
426.09
titre
—
10
69
122
992
1.46
2.22
3.8
2.6
—
—
estimate
—
0
0
12
48
2.58
2.22
1.1
1.1
—
—
—
0
0
9
30
3.07
2.17
1.1
1.3
—
—
—
0
0
121
987
1.44
2.14
13.5
14.1
1.30
1.25
inr
0.46
105
809
139
1168
1.44
2.07
4.7
3.7
0.00
0.00
estimate
-0.00
24
262
26
149
1.83
2.04
1.5
1.4
—
—
—
0
0
12
51
2.42
1.98
1.4
2.5
73.31
55.72
%
1.74
12
51
6
16
3.82
1.94
2.3
1.4
38.67
39.15
%
—
6
16
0
54
0.00
1.87
0.0
2.9
—
58.78
—
0
54
54
386
1.51
1.84
2.0
2.0
—
—
—
0
0
8
178
0.43
1.78
3.4
3.6
—
—
—
0
0
136
1159
1.39
1.76
4.8
3.7
0.00
0.00
estimate
-0.00
23
257
11
226
0.46
1.76
1.4
1.4
—
—
—
0
0
51
365
1.50
1.73
3.9
2.7
0.81
0.82
mmol/l
0.46
45
350
70
534
1.43
1.72
2.6
2.1
2.58
2.96
mg/l
0.58
65
464
138
1182
1.38
1.72
4.7
3.8
0.17
0.02
estimate
0.43
23
252
10
41
2.50
1.66
1.8
1.8
—
—
—
0
0
12
57
2.16
1.58
1.0
1.2
—
—
—
0
0
12
57
2.16
1.58
1.4
1.2
—
—
—
0
0
166
1483
1.37
1.49
4.2
4.0
—
16836.17
—
0
6
0
39
0.00
1.35
0.0
3.3
—
4.14
—
0
39
11
54
2.09
1.35
1.4
1.1
—
—
—
0
0
19
114
1.72
1.32
4.0
3.7
—
—
—
0
0
9
43
2.13
1.31
1.7
1.4
—
—
—
0
0
28
188
1.55
1.28
4.7
4.1
0.44
0.65
%
—
9
52
9
44
2.08
1.28
1.8
1.6
—
—
—
0
0
29
197
1.54
1.26
3.0
2.4
0.20
0.22
g/l
1.21
24
184
13
70
1.90
1.26
2.8
1.8
—
—
—
0
0
18
108
1.72
1.26
1.4
1.3
22.62
26.23
iu/l
0.20
13
86
189
1742
1.37
1.26
30.0
18.6
13.69
13.58
%
0.48
189
1727
41
300
1.44
1.25
1.4
1.2
—
—
—
0
0
5
19
2.66
1.22
1.2
1.1
—
—
—
0
0
14
81
1.77
1.11
4.4
3.2
—
—
—
0
0
8
41
1.98
1.10
1.0
1.3
83.88
55.79
mmol/l
—
8
34
7
33
2.15
1.06
1.1
1.4
—
—
—
0
0
5
22
2.30
1.04
1.0
2.1
—
—
—
0
0
10
54
1.89
0.98
2.0
1.5
—
—
—
0
0
13
77
1.73
0.97
1.4
1.3
—
—
—
0
0
35
262
1.39
0.96
2.0
1.4
—
—
—
0
0
11
62
1.81
0.96
2.1
1.8
—
—
—
0
0
62
510
1.29
0.92
3.6
3.9
1.02
1.02
kg/l
0.98
42
340
54
657
0.77
0.91
4.2
3.9
0.00
0.01
estimate
0.74
24
239
12
71
1.73
0.90
1.1
1.3
—
—
—
0
0
27
197
1.42
0.87
5.1
4.3
0.63
0.68
%
—
8
57
32
241
1.38
0.86
1.6
1.5
—
—
—
0
0
17
113
1.54
0.84
1.5
1.7
0.32
0.27
mg/l
—
5
46
82
707
1.24
0.82
3.1
3.0
7.27
7.64
mmol/l
0.36
71
602
6
32
1.90
0.82
1.0
1.1
—
—
—
0
0
26
191
1.40
0.81
5.2
4.3
0.00
0.18
%
—
7
49
0
25
0.00
0.79
0.0
1.5
—
—
—
0
0
5
24
2.11
0.75
1.4
1.3
6.21
6.65
g/l
—
5
17
5
24
2.11
0.75
1.4
1.3
2.48
3.13
g/l
—
5
16
5
24
2.11
0.75
1.4
1.3
0.56
0.32
g/l
—
5
17
210
2011
1.30
0.73
5.3
5.0
6.00
5.88
mmol/l
0.56
203
1862
14
93
1.54
0.71
2.4
1.6
—
—
—
0
0
5
26
1.94
0.71
1.2
1.1
—
—
—
0
0
5
26
1.94
0.71
1.4
1.3
—
—
—
0
0
15
102
1.50
0.69
1.3
1.2
—
1.92
—
0
5
16
111
1.47
0.68
1.0
1.1
—
14.20
—
0
5
16
111
1.47
0.68
1.3
1.1
—
—
—
0
0
7
44
1.61
0.65
1.7
1.3
1.06
0.95
nmol/l
—
7
37
215
2077
1.28
0.59
23.3
14.6
26.78
22.93
mg/l
0.85
188
1696
203
1949
1.24
0.59
6.3
6.0
38.46
38.93
mmol/mol
0.38
198
1844
14
195
0.70
0.59
1.3
1.4
—
—
—
0
0
6
35
1.73
0.58
1.2
1.0
—
—
—
0
0
41
341
1.24
0.57
1.5
1.6
—
—
—
0
0
6
36
1.68
0.57
1.0
1.1
—
—
—
0
0
13
90
1.47
0.56
2.1
2.5
—
—
—
0
0
9
61
1.49
0.54
1.2
1.1
—
104.29
—
0
7
6
39
1.55
0.53
1.0
1.1
—
—
—
0
0
6
39
1.55
0.53
1.0
1.1
—
—
—
0
0
11
157
0.69
0.53
4.2
3.1
—
—
—
0
0
25
198
1.29
0.52
5.6
4.8
0.00
0.13
%
—
6
47
80
885
0.86
0.50
3.8
3.1
—
—
—
0
0
12
84
1.45
0.50
2.2
1.4
565.17
318.00
mu/l
0.52
12
77
73
652
1.17
0.50
3.5
3.8
7.85
8.88
mg/mmol
0.07
40
411
16
119
1.37
0.49
7.8
5.6
25.09
24.78
mmol/l
0.11
16
114
35
292
1.23
0.48
1.4
1.3
—
—
—
0
0
7
48
1.47
0.47
9.7
4.9
1.13
1.19
mmol/l
—
7
41
39
452
0.84
0.43
1.5
1.8
437.94
13021282.37
pmol/l
0.50
33
384
69
621
1.15
0.43
1.5
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.4
—
15.81
—
0
15
0
17
0.00
0.41
0.0
1.4
—
6.72
—
0
17
17
133
1.30
0.40
3.2
1.7
—
—
—
0
0
0
19
0.00
0.39
0.0
1.0
—
382.40
—
0
10
22
179
1.25
0.39
3.5
2.5
0.24
0.22
e6/l
0.03
22
166
5
37
1.36
0.37
1.0
1.1
—
—
—
0
0
12
90
1.35
0.36
1.2
1.1
—
—
—
0
0
6
42
1.44
0.36
3.3
1.2
—
—
—
0
0
6
42
1.44
0.36
1.2
1.2
—
—
—
0
0
22
182
1.23
0.34
3.2
2.4
6.23
6.16
ph
0.14
15
119
94
876
1.12
0.34
2.1
1.9
1.38
1.37
mmol/l
0.08
87
737
28
239
1.19
0.33
1.2
1.4
—
—
—
0
0
47
518
0.89
0.28
6.4
5.1
—
—
—
0
0
10
128
0.77
0.27
1.5
1.8
—
—
—
0
0
19
224
0.84
0.26
2.6
1.4
—
—
—
0
0
229
2258
1.21
0.26
32.7
22.7
252.43
250.31
e9/l
0.20
224
2223
70
653
1.10
0.25
3.2
2.4
52.44
72.97
u/l
1.24
63
594
229
2259
1.20
0.24
32.7
22.7
6.74
6.70
e9/l
0.12
224
2216
229
2259
1.20
0.24
32.6
22.6
4.43
4.49
e12/l
0.92
224
2219
79
742
1.10
0.24
3.6
3.2
2.36
2.35
mmol/l
0.24
74
685
16
134
1.21
0.23
3.6
2.9
83.06
62.85
u/ml
0.17
16
128
93
884
1.08
0.22
4.5
3.7
0.00
0.03
estimate
1.15
14
221
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
1733.90
—
0
10
0
12
0.00
0.21
0.0
1.7
—
67.58
—
0
12
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
70
659
1.09
0.20
4.4
3.2
0.00
0.01
estimate
0.74
16
201
12
99
1.22
0.20
1.0
1.1
—
—
—
0
0
6
53
1.14
0.19
1.3
2.2
178.00
251.76
pmol/l
—
6
46
84
802
1.07
0.17
3.7
3.5
27.69
36.22
ng/l
0.43
58
552
10
82
1.23
0.17
2.1
1.4
—
—
—
0
0
7
63
1.11
0.17
1.7
2.7
1.41
1.41
mg/l
—
7
52
217
2142
1.11
0.17
16.6
13.1
—
—
—
0
0
8
70
1.15
0.16
2.0
2.8
—
—
—
0
0
6
77
0.77
0.16
1.0
1.1
1.59
1.60
g/l
—
6
77
6
78
0.76
0.16
1.0
1.2
0.94
0.90
g/l
—
6
78
15
171
0.87
0.15
1.8
1.9
3.28
3.51
mmol/l
—
10
129
19
169
1.13
0.15
1.6
3.0
67.02
67.85
e9/l
—
9
124
211
2083
1.09
0.15
6.0
5.7
2.75
2.74
mmol/l
0.06
201
1945
10
85
1.18
0.12
5.7
3.0
2931.90
2221.75
u/ml
—
10
79
193
1954
0.94
0.11
4.2
4.2
1.45
1.27
mmol/l
2.12
183
1807
23
212
1.09
0.10
2.0
1.8
—
—
—
0
0
67
645
1.05
0.10
2.8
3.1
42.45
55.43
mg/l
0.25
41
414
22
204
1.09
0.09
1.5
2.0
0.00
0.00
estimate
—
6
44
148
1458
1.04
0.08
3.7
3.2
52.78
44.16
u/l
0.63
140
1372
207
2057
1.04
0.04
5.1
5.0
4.74
4.67
mmol/l
0.41
199
1925
203
2043
0.96
0.04
5.0
4.9
1.49
1.49
mmol/l
0.05
194
1900
10
92
1.09
0.03
3.2
1.5
—
—
—
0
0
33
338
0.97
0.02
2.9
3.1
0.86
0.84
ug/l
0.03
23
202
24
247
0.97
0.01
1.5
1.5
—
—
—
0
0
10
98
1.02
0.00
3.2
1.5
—
—
—
0
0
10
101
0.99
0.00
3.2
1.4
—
—
—
0
0
34
335
1.02
0.00
1.4
1.8
857.89
1209.76
nmol/l
1.86
28
252
5
58
0.86
0.00
1.6
2.3
37.80
24.84
mg/l
—
5
49
5
58
0.86
0.00
1.6
2.3
45.56
162.80
mg/l
—
5
49
10
100
1.00
-0.00
3.2
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
184.67
—
0
7
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
6
66
0.91
-0.00
1.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
0.03
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
139.40
—
0
5
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
62.00
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
58.67
—
0
6
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
0.00
—
0
7
10
100
1.00
-0.00
3.2
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: AB1_TYPHOIDPARATHYPHOID_WIDE – Typhoid and paratyphoid fevers, including avohilmo

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).