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Toxoplasmosis, including avohilmo

Endpoint Browser PheWeb

AB1_TOXOPLASMOSIS_WIDE

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519870

1. Apply sex-specific rule

None

519870

2. Check conditions

None

519870

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Primary healthcare outpatient: ICD-10 — B58
  • Hospital discharge: ICD-10 — B58
  • Hospital discharge: ICD-9 — 130
  • Hospital discharge: ICD-8 — 130
  • Cause of death: ICD-10 — B58
  • Cause of death: ICD-9 — 130
  • Cause of death: ICD-8 — 130

3 out of 7 registries used, show all original rules.

215

4. Check minimum number of events

None

215

5. Include endpoints

None

215

6. Filter based on genotype QC (FinnGen only)

211

Control definitions (FinnGen only)

Control exclude
AB1_PROTOZOAL

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 211 137 74
Unadjusted period prevalence (%) 0.04 0.05 0.03
Median age at first event (years) 33.74 32.48 36.06

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
215
Matched controls
2150
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H32.0*B58.0
ICD-10 Finland
Toxoplasma chorioretinitis
+∞
75.6
68
*
B58.9
ICD-10 Finland
Toxoplasmosis, unspecified
+∞
33.2
31
*
B58.0
ICD-10 Finland
Toxoplasma oculopathy
+∞
33.2
31
*
13000
ICD-8 Finland
Toxoplasmosis, Acquired
+∞
29.9
28
*
13099
ICD-8 Finland
Toxoplasmosis, Unspecified
+∞
19.0
18
*
1302A
ICD-9 Finland
Toxoplasmosis, Chorioretinitis due to toxoplasmosis
+∞
19.0
18
*
H32.0
ICD-10 Finland
Chorioretinal inflammation in infectious and parasitic diseases classified elsewhere
+∞
18.0
17
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
6.5
13.4
23
39
H30.0
ICD-10 Finland
Focal chorioretinal inflammation
+∞
12.6
12
*
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic
21.5
11.3
16
8
1309X
ICD-9 Finland
Toxoplasmosis, unspecified
+∞
10.5
10
*
H30.9
ICD-10 Finland
Chorioretinal inflammation, unspecified
104.4
9.5
10
*
H02AB07
ATC
prednisone; oral
3.1
9.5
45
168
S01BA04
ATC
prednisolone; ophthalmic
9.7
9.2
18
20
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.8
9.2
56
240
XCK10
NOMESCO Finland
Photography of fundus of eye
3.4
8.6
33
108
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
4.6
8.1
20
47
J01FF01
ATC
clindamycin; systemic
2.4
7.8
75
398
H30.2
ICD-10 Finland
Posterior cyclitis
82.8
7.5
8
*
36504
ICD-8 Finland
Choroiditis, Retinis, Retino-chorioiditis
+∞
7.3
7
*
13020
ICD-8 Finland
Toxoplasmosis, Late effects of intra-utrine infection
+∞
7.3
7
*

TimeCodeWAS

↥

TODO / Current known limitations:

  • Only showing the top 500 codes, because showing all (sometimes 20k) makes the page too slow.
  • Legend / how to read the glyphs.
  • Proper column names.
  • Show details (e.g. Fisher or Chi-square test, N cases and N controls) when clicking on a row.
  • Explanation on the underlying data / how the TimeCodeWAS is done (e.g. matched cases / controls, eligibility).
  • Download CSV not working.
  • No filters and sorters.
  • Limited amount of endpoints with TimeCodeWAS data.
  • Cross-links to Risteys lab test pages for lab test codes.
OMOP Concept
ln(OR) -5y
ln(OR) -1y
ln(OR) -1m
ln(OR) d0
ln(OR) +1m
ln(OR) +1y
ln(OR) +5y
MCC -5y
MCC -1y
MCC -1m
MCC d0
MCC +1m
MCC +1y
MCC +5y
Toxoplasma chorioretinitis
H32.0*B58.0 (2000502311)
Toxoplasma oculopathy
B58.0 (45571475)
Toxoplasmosis, unspecified
B58.9 (45585965)
sulfadiazine and trimethoprim
J01EE02 (21602962)
clindamycin; oral, parenteral
J01FF01 (21602985)
Body height measure
50373000 (4177340)
Body mass index
60621009 (4245997)
Toxoplasmosis, Chorioretinitis due to toxoplasmosis
1302A (2000400924)
Internal Medicine
11 (38004456)
Ophthalmology
18 (38004463)
Infectious Disease
44 (38004484)
Inpatient Hospital
21 (8717)
Inpatient Visit
IP (9201)
Emergency Room Visit
ER (9203)
Outpatient Visit
OP (9202)
Supplier / Service Provider
OMOP5117446 (33004)
Pharmacy visit
OMOP4822462 (581458)

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
23
20
12.73
13.17
2.9
3.1
61.59
—
iu/ml
—
10
0
63
295
2.61
8.65
1.2
1.4
360.00
510.12
titre
0.60
15
81
10
9
11.58
5.85
3.5
1.2
1064.20
879.00
u/ml
—
10
9
94
631
1.87
4.73
11.0
5.7
—
—
—
0
0
143
1098
1.90
4.67
12.7
9.9
4.02
4.09
e9/l
0.13
124
961
11
18
6.38
4.66
1.2
1.2
—
—
—
0
0
133
1003
1.85
4.54
9.0
6.2
1.88
1.82
e9/l
0.38
117
881
130
985
1.81
4.26
9.1
6.2
0.57
0.57
e9/l
0.01
111
841
130
989
1.80
4.16
9.1
6.2
0.04
0.04
e9/l
0.44
111
842
122
917
1.76
4.01
9.4
6.2
29.27
28.05
%
0.64
115
872
14
43
3.41
3.98
1.2
1.4
—
—
—
0
0
11
23
4.98
3.93
1.2
1.3
—
—
—
0
0
132
1020
1.76
3.89
10.5
6.4
0.19
0.19
e9/l
0.09
115
885
119
895
1.74
3.85
9.9
6.2
0.77
0.70
%
0.53
111
833
119
900
1.72
3.73
9.8
6.2
2.70
2.80
%
0.20
112
845
13
36
3.78
3.56
1.5
1.3
277.80
243.82
u/ml
—
5
17
14
47
3.12
3.48
1.3
1.1
—
—
—
0
0
118
903
1.68
3.44
10.0
6.2
8.85
8.68
%
0.31
111
851
21
90
2.48
3.37
2.7
1.8
5.88
4.37
iu/ml
—
9
20
72
491
1.70
3.19
2.6
2.7
354.72
333.84
umol/l
0.92
65
437
86
617
1.66
3.14
3.9
3.3
25.05
146.28
e6/l
0.60
61
473
16
65
2.58
2.86
1.5
1.4
—
—
—
0
0
49
309
1.76
2.84
3.5
2.3
12.88
13.69
umol/l
0.32
43
289
64
435
1.67
2.83
3.4
2.6
6.57
5.65
e6/l
0.13
57
401
46
285
1.78
2.83
3.7
2.3
2.35
2.36
g/l
0.05
40
263
75
535
1.62
2.73
3.9
3.0
0.39
0.37
e6/l
0.04
52
395
5
7
7.28
2.56
1.0
1.0
—
—
—
0
0
67
475
1.60
2.47
7.7
4.2
—
—
—
0
0
80
595
1.55
2.39
6.9
4.1
7.40
7.40
ph
0.09
55
416
26
142
1.95
2.36
3.0
2.5
35.84
19.18
au/ml
—
5
15
94
729
1.51
2.30
4.8
3.9
72.36
62.27
e6/l
0.10
66
501
15
67
2.33
2.23
4.3
4.0
121.78
267.33
mg/l
—
9
24
31
185
1.79
2.16
5.3
3.3
1.72
1.91
%
0.65
24
172
41
267
1.66
2.10
3.9
2.4
20.71
23.02
%
0.50
36
251
8
26
3.15
2.03
1.3
1.2
—
—
—
0
0
55
389
1.56
2.02
1.8
2.1
—
—
—
0
0
41
272
1.63
1.96
1.3
2.2
53.10
99.57
ug/g
1.36
35
221
166
1475
1.55
1.95
10.4
7.8
83.43
78.33
u/l
0.60
160
1392
80
617
1.47
1.94
2.7
2.2
—
—
—
0
0
36
232
1.66
1.92
1.7
1.9
—
—
—
0
0
8
28
2.93
1.88
1.4
1.4
—
—
—
0
0
78
604
1.46
1.84
9.9
6.6
—
—
—
0
0
61
450
1.50
1.83
4.8
3.7
—
0.00
—
0
5
5
12
4.24
1.83
1.0
1.0
—
—
—
0
0
25
148
1.78
1.80
1.0
1.2
204.38
104.25
u/ml
—
9
57
103
844
1.42
1.78
4.1
3.4
6.12
6.19
ph
0.21
53
481
9
36
2.56
1.76
1.0
1.1
—
—
—
0
0
26
157
1.75
1.75
2.0
1.5
—
—
—
0
0
13
61
2.20
1.75
2.1
1.7
113.00
305.99
ug/l
1.71
13
55
21
119
1.85
1.73
1.6
2.5
—
—
—
0
0
0
46
0.00
1.73
0.0
5.0
—
24.11
—
0
32
36
242
1.59
1.64
2.9
2.5
11.07
7.44
umol/l
0.29
30
214
5
14
3.63
1.62
12.4
5.2
1897.80
919.36
mg
—
5
14
109
913
1.39
1.61
9.8
7.0
1.21
1.22
mmol/l
0.52
91
790
8
32
2.56
1.61
1.0
1.0
—
—
—
0
0
7
27
2.64
1.53
1.0
1.2
—
—
—
0
0
101
842
1.38
1.51
8.3
6.2
1.21
1.22
mmol/l
1.04
91
781
18
102
1.83
1.50
6.4
3.8
22.93
24.53
mmol/l
2.69
18
102
22
135
1.70
1.42
3.9
3.2
63.54
75.05
e9/l
0.85
17
97
58
447
1.41
1.37
5.5
3.9
1.02
1.02
kg/l
0.13
37
296
206
1978
1.99
1.36
25.9
18.7
77.68
74.47
umol/l
0.70
206
1951
28
186
1.58
1.35
6.6
8.7
7.42
7.41
ph
0.46
16
112
38
271
1.49
1.34
2.9
1.9
—
—
—
0
0
28
187
1.57
1.32
6.2
8.7
0.14
0.90
mmol/l
0.59
20
154
57
442
1.39
1.29
2.0
1.8
0.95
1.23
mg/l
0.54
44
358
121
1062
1.32
1.19
4.8
3.8
0.00
0.01
estimate
0.50
21
212
6
26
2.34
1.19
1.5
1.3
—
—
—
0
0
6
26
2.34
1.19
1.5
1.3
—
—
—
0
0
6
26
2.34
1.19
1.5
1.3
—
—
—
0
0
6
26
2.34
1.19
1.5
1.3
—
—
—
0
0
120
1054
1.31
1.17
4.9
3.7
0.00
7.12
estimate
0.50
21
228
5
20
2.53
1.15
1.2
1.1
269.40
261.53
mosm/kgh2o
—
5
15
53
415
1.37
1.13
1.3
1.3
21.68
24.65
iu/ml
0.14
13
128
14
81
1.78
1.12
1.0
1.1
—
—
—
0
0
198
1888
1.62
1.09
21.5
14.5
23.50
21.38
mg/l
0.32
161
1527
34
248
1.44
1.08
2.4
1.6
—
—
—
0
0
118
1045
1.29
1.04
4.8
3.7
0.00
0.00
estimate
-0.00
21
221
6
28
2.17
0.92
1.2
1.1
—
—
—
0
0
6
28
2.17
0.92
1.3
1.4
—
—
—
0
0
89
770
1.27
0.92
2.3
2.0
—
—
—
0
0
95
829
1.26
0.91
6.5
4.7
35.22
36.24
g/l
0.89
88
789
8
43
1.89
0.88
3.4
2.4
54.88
61.56
%
—
8
43
24
171
1.45
0.88
6.7
3.9
7.36
7.39
ph
1.27
17
98
6
30
2.03
0.87
4.0
2.3
3.48
5.17
e9/l
—
6
30
91
793
1.26
0.87
4.8
3.6
0.00
0.02
estimate
0.74
18
188
58
479
1.29
0.86
2.7
2.0
2.52
2.78
mg/l
0.59
50
415
8
45
1.81
0.85
8.0
3.5
7.42
7.41
ph
—
8
45
61
509
1.28
0.83
1.2
1.3
2.26
1.20
u/ml
0.34
11
149
189
1804
1.39
0.82
5.2
5.0
5.85
5.88
mmol/l
0.15
177
1687
6
32
1.90
0.82
7.3
2.9
9.23
8.73
kpa
—
6
32
6
32
1.90
0.82
7.3
2.9
4.65
4.98
kpa
—
6
32
8
47
1.73
0.81
3.9
2.4
58.58
58.59
%
—
8
47
6
34
1.79
0.77
7.7
2.5
—
—
—
0
0
44
356
1.30
0.76
4.3
3.3
224.29
284.83
ng/l
0.12
35
273
185
1765
1.35
0.76
5.9
5.6
1.90
1.86
mu/l
0.18
174
1642
42
338
1.30
0.76
1.9
1.7
—
—
—
0
0
67
572
1.25
0.76
3.9
3.0
—
—
—
0
0
5
24
2.11
0.75
1.6
1.7
33.00
32.42
pg
—
5
24
5
24
2.11
0.75
1.2
1.1
—
—
—
0
0
6
110
0.53
0.74
1.3
1.2
—
—
—
0
0
75
650
1.24
0.74
3.9
3.1
7.73
7.87
mmol/l
0.09
64
560
55
460
1.26
0.74
1.6
1.4
2.23
2.47
g/l
0.31
35
279
24
178
1.39
0.72
1.2
1.2
—
—
—
0
0
195
1878
1.41
0.72
5.2
5.1
4.61
4.71
mmol/l
0.56
183
1768
5
26
1.94
0.71
2.2
1.9
—
—
—
0
0
22
162
1.40
0.69
4.3
3.2
—
—
—
0
0
5
27
1.87
0.69
1.0
1.5
0.18
0.16
nmol/l
—
5
19
73
827
0.82
0.66
3.1
3.0
—
—
—
0
0
7
44
1.61
0.66
3.1
2.2
8.93
8.36
kpa
—
7
44
5
29
1.74
0.64
1.0
1.1
—
—
—
0
0
16
221
0.70
0.64
1.0
1.3
—
—
—
0
0
196
1898
1.37
0.60
5.7
5.7
2.68
2.76
mmol/l
0.65
182
1783
35
284
1.28
0.60
3.6
3.0
1.77
2.33
e6/l
0.32
13
130
74
653
1.20
0.60
3.4
3.4
2.37
2.36
mmol/l
0.13
66
596
13
89
1.49
0.59
3.5
4.4
—
—
—
0
0
79
704
1.19
0.58
3.7
3.6
23.45
26.39
ng/l
0.27
47
466
185
1782
1.27
0.56
4.5
4.2
1.31
1.29
mmol/l
0.08
169
1654
33
269
1.27
0.55
1.2
1.3
—
—
—
0
0
159
1511
1.20
0.53
4.8
4.6
14.67
14.76
pmol/l
0.17
148
1396
193
1871
1.31
0.53
5.1
5.0
1.47
1.48
mmol/l
0.11
178
1753
19
144
1.35
0.53
9.2
10.0
—
—
—
0
0
9
65
1.40
0.51
1.6
1.3
—
—
—
0
0
7
50
1.41
0.45
6.0
9.9
—
—
—
0
0
104
965
1.15
0.44
3.8
3.0
125.16
102.34
ug/l
0.69
95
913
97
896
1.15
0.44
19.4
10.8
0.00
0.00
e9/l
0.93
76
731
62
555
1.16
0.42
1.8
1.6
15.92
21.81
nmol/l
3.76
55
469
78
851
0.87
0.42
2.1
1.9
1.37
1.39
mmol/l
0.08
67
727
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
279.10
—
0
10
16
124
1.31
0.40
1.4
1.2
—
—
—
0
0
44
385
1.18
0.39
1.3
1.3
7.52
9.06
u/ml
0.11
19
151
5
35
1.44
0.39
8.6
3.1
9.10
8.70
pmol/l
—
5
35
16
125
1.30
0.38
4.9
3.4
—
—
—
0
0
6
45
1.34
0.34
2.8
2.1
21.15
24.88
mmol/l
—
6
45
199
1952
1.26
0.34
18.0
12.7
—
—
—
0
0
95
889
1.12
0.33
3.4
2.7
—
—
estimate
—
0
0
30
258
1.19
0.33
1.6
1.6
—
—
—
0
0
7
57
1.24
0.29
1.1
1.2
—
—
—
0
0
12
94
1.29
0.28
1.1
1.2
—
—
—
0
0
12
95
1.28
0.27
2.4
2.3
—
—
—
0
0
6
81
0.73
0.24
1.2
1.1
0.74
0.89
g/l
—
6
81
5
39
1.29
0.23
1.0
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
141.94
—
0
10
63
591
1.09
0.20
3.7
3.2
108.83
53.14
mg/l
0.78
41
378
6
49
1.23
0.20
1.2
1.2
—
—
—
0
0
7
59
1.19
0.18
1.4
1.2
—
—
—
0
0
22
196
1.14
0.17
1.5
4.4
2.13
31.01
ug/l
0.75
15
164
6
78
0.76
0.16
1.2
1.1
1.43
1.53
g/l
—
6
78
27
247
1.11
0.14
1.3
1.2
—
—
—
0
0
19
170
1.13
0.14
1.7
1.3
—
—
—
0
0
63
601
1.07
0.13
4.0
3.1
0.05
0.01
estimate
0.35
19
186
87
839
1.06
0.13
18.6
11.1
1.22
1.18
inr
0.34
72
679
24
219
1.11
0.13
2.2
1.6
—
—
—
0
0
85
822
1.06
0.12
2.4
2.1
105.43
96.77
pmol/l
0.81
45
426
39
368
1.07
0.11
2.6
2.6
2.42
2.45
mmol/l
1.04
33
335
10
115
0.86
0.11
1.3
1.8
—
—
—
0
0
5
65
0.76
0.08
2.4
2.2
—
—
—
0
0
11
98
1.13
0.08
3.2
1.4
—
—
—
0
0
59
571
1.05
0.07
5.5
3.8
0.00
0.00
estimate
-0.00
17
210
135
1370
0.96
0.07
4.1
3.3
58.21
44.69
u/l
0.65
130
1305
48
463
1.05
0.07
6.0
4.6
—
—
—
0
0
64
623
1.04
0.06
2.6
2.4
56.36
63.49
u/l
0.46
55
582
17
160
1.07
0.04
3.8
2.5
6.33
6.18
ph
—
9
105
62
607
1.03
0.04
4.3
3.9
24.83
8.91
mg/mmol
0.79
38
371
11
101
1.09
0.04
3.4
1.4
—
—
—
0
0
11
101
1.09
0.04
2.5
1.4
—
—
—
0
0
11
101
1.09
0.04
3.5
1.4
—
—
—
0
0
58
570
1.02
0.02
1.6
1.5
—
—
—
0
0
12
113
1.07
0.02
2.7
2.9
7.41
7.43
ph
0.53
12
90
25
243
1.03
0.01
7.3
7.4
105.00
104.14
mmol/l
0.81
25
243
10
94
1.07
0.01
1.8
1.8
—
—
—
0
0
11
109
1.01
0.00
1.0
1.1
—
—
—
0
0
25
246
1.02
0.00
1.4
1.4
—
—
—
0
0
28
284
0.98
0.00
2.4
2.9
0.44
0.77
ug/l
1.82
17
166
178
1776
1.01
0.00
5.8
6.1
38.32
38.99
mmol/mol
0.61
167
1688
29
285
1.02
0.00
2.3
1.7
1163.59
1193.15
nmol/l
0.07
20
218
0
5
0.00
0.00
0.0
1.4
—
1.67
—
0
5
0
5
0.00
0.00
0.0
2.2
—
3713.80
—
0
5
0
5
0.00
0.00
0.0
1.0
—
27.80
—
0
5
5
50
1.00
-0.00
3.8
1.5
—
—
—
0
0
8
82
0.97
-0.00
1.5
1.6
200.15
274.44
mu/l
—
8
77
8
83
0.96
-0.00
2.0
3.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
55
0.91
-0.00
2.0
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
54
0.92
-0.00
2.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
5.8
—
46.50
—
0
6
9
96
0.93
-0.00
3.7
1.4
—
—
—
0
0

Mortality – FinRegistry

↥

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

↥

Index endpoint: AB1_TOXOPLASMOSIS_WIDE – Toxoplasmosis, including avohilmo

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).