No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
239 |
4. Check minimum number of eventsNone |
239 |
5. Include endpointsNone |
239 |
6. Filter based on genotype QC (FinnGen only) |
206 |
Control definitions (FinnGen only)
- Control exclude
- AB1_PROTOZOAL
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Toxoplasmosis
based on the number of shared cases.
Similar with more cases:
- Toxoplasmosis, including avohilmo
- Protozoal diseases
- Protozoal diseases, including avohilmo
- Certain infectious and parasitic diseases
- Certain infectious and parasitic diseases, including avohilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1599 | 935 | 652 |
| Only index persons | 1392 | 844 | 548 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 31.42 | 32.08 | 30.30 |
| Only index persons | 30.26 | 31.16 | 28.88 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 206 | 134 | 72 |
| Unadjusted period prevalence (%) | 0.04 | 0.05 | 0.03 |
| Median age at first event (years) | 33.63 | 32.33 | 36.06 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 210
- Matched controls
- 2100
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H32.0*B58.0
ICD-10 Finland
Toxoplasma chorioretinitis
+∞
75.7
68
*
B58.9
ICD-10 Finland
Toxoplasmosis, unspecified
+∞
31.0
29
*
13000
ICD-8 Finland
Toxoplasmosis, Acquired
+∞
29.9
28
*
B58.0
ICD-10 Finland
Toxoplasma oculopathy
+∞
29.9
28
*
13099
ICD-8 Finland
Toxoplasmosis, Unspecified
+∞
19.0
18
*
1302A
ICD-9 Finland
Toxoplasmosis, Chorioretinitis due to toxoplasmosis
+∞
19.0
18
*
H32.0
ICD-10 Finland
Chorioretinal inflammation in infectious and parasitic diseases classified elsewhere
+∞
18.0
17
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
6.9
14.1
23
37
H30.0
ICD-10 Finland
Focal chorioretinal inflammation
+∞
12.6
12
*
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic
21.5
11.3
16
8
1309X
ICD-9 Finland
Toxoplasmosis, unspecified
+∞
10.5
10
*
H02AB07
ATC
prednisone; oral
3.2
10.0
45
163
S01BA04
ATC
prednisolone; ophthalmic
9.7
9.2
18
20
XCK10
NOMESCO Finland
Photography of fundus of eye
3.5
9.0
33
105
H30.9
ICD-10 Finland
Chorioretinal inflammation, unspecified
93.7
8.5
9
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.7
8.4
54
238
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
4.6
8.1
20
47
J01FF01
ATC
clindamycin; systemic
2.3
7.5
73
389
H30.2
ICD-10 Finland
Posterior cyclitis
82.9
7.5
8
*
36504
ICD-8 Finland
Choroiditis, Retinis, Retino-chorioiditis
+∞
7.3
7
*
13020
ICD-8 Finland
Toxoplasmosis, Late effects of intra-utrine infection
+∞
7.3
7
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
20
20
10.92
10.77
3.0
3.1
64.72
—
iu/ml
—
9
0
10
9
11.59
5.86
3.5
1.2
1064.20
879.00
u/ml
—
10
9
139
1080
1.85
4.22
12.9
10.0
4.07
4.09
e9/l
0.03
120
946
16
53
3.19
4.06
1.4
1.5
0.02
0.10
iu/ml
—
5
7
7
8
9.00
3.80
3.3
1.3
—
—
—
0
0
72
477
1.78
3.62
2.6
2.7
354.72
334.46
umol/l
0.87
65
424
21
88
2.54
3.52
2.7
1.8
5.88
4.37
iu/ml
—
9
20
12
32
3.91
3.45
1.0
1.2
—
—
—
0
0
12
36
3.47
3.07
1.4
1.3
277.80
243.82
u/ml
—
5
17
35
195
1.95
2.99
6.0
4.8
233.97
252.49
u/l
0.49
30
187
12
37
3.38
2.99
1.5
1.4
—
—
—
0
0
12
38
3.29
2.90
1.8
1.3
—
—
—
0
0
48
304
1.75
2.74
3.6
2.3
12.77
13.62
umol/l
0.32
42
284
45
280
1.77
2.73
3.7
2.3
2.35
2.36
g/l
0.02
39
258
8
19
4.33
2.70
1.0
1.1
—
—
—
0
0
12
41
3.04
2.67
1.4
1.3
—
—
—
0
0
15
62
2.53
2.60
2.1
2.5
—
—
—
0
0
8
20
4.11
2.59
1.0
1.2
—
—
—
0
0
5
7
7.28
2.56
16.0
2.4
—
—
—
0
0
5
7
7.28
2.56
16.0
2.4
—
—
—
0
0
5
7
7.28
2.56
1.0
1.0
—
—
—
0
0
8
21
3.92
2.49
1.0
1.1
—
—
—
0
0
72
525
1.57
2.36
3.9
3.0
0.40
0.37
e6/l
0.07
49
387
0
59
0.00
2.28
0.0
1.7
—
—
—
0
0
11
41
2.77
2.24
8.9
1.8
—
—
—
0
0
161
1409
1.61
2.23
5.3
4.2
13.54
11.13
mm/h
1.05
151
1307
5
9
5.66
2.22
1.0
1.0
—
—
—
0
0
5
9
5.66
2.22
1.2
1.3
12.60
13.89
u/l
—
5
9
7
20
3.58
2.07
3.0
4.1
—
—
—
0
0
40
264
1.64
1.96
3.9
2.4
20.67
22.99
%
0.49
35
248
5
12
4.24
1.83
1.6
1.3
—
—
—
0
0
13
60
2.24
1.82
2.1
1.7
113.00
310.12
ug/l
1.73
13
54
36
237
1.63
1.78
2.9
2.6
11.07
7.52
umol/l
0.28
30
210
162
1448
1.52
1.77
10.5
7.9
84.02
78.53
u/l
0.65
156
1367
58
430
1.48
1.70
5.5
4.0
1.02
1.02
kg/l
0.12
37
288
21
121
1.82
1.65
2.9
1.6
—
—
—
0
0
5
14
3.63
1.62
12.4
5.2
1897.80
919.36
mg
—
5
14
5
14
3.63
1.62
1.0
1.1
—
—
—
0
0
18
101
1.86
1.54
6.4
3.8
22.93
24.52
mmol/l
2.67
18
101
0
42
0.00
1.54
0.0
1.6
—
51.80
—
0
42
43
306
1.51
1.53
3.3
2.9
0.80
1.00
e6/l
0.30
20
152
5
15
3.39
1.53
1.6
2.6
—
—
—
0
0
106
893
1.38
1.50
9.9
7.1
1.21
1.22
mmol/l
0.60
88
771
28
183
1.61
1.44
6.2
8.8
0.13
0.96
mmol/l
0.65
20
150
7
29
2.46
1.40
1.1
1.5
—
—
—
0
0
6
23
2.65
1.37
1.5
2.0
—
—
—
0
0
41
296
1.48
1.37
3.0
1.8
—
—
—
0
0
98
826
1.35
1.34
8.4
6.2
1.21
1.22
mmol/l
1.13
88
765
12
63
1.96
1.25
1.7
1.2
—
—
—
0
0
201
1933
1.93
1.25
26.2
18.9
77.80
74.65
umol/l
0.66
201
1907
56
436
1.39
1.25
2.0
1.8
0.97
1.24
mg/l
0.48
43
355
11
57
1.98
1.19
2.3
1.8
—
—
—
0
0
52
403
1.39
1.19
1.3
1.3
21.68
24.65
iu/ml
0.14
13
128
0
33
0.00
1.17
0.0
1.7
—
—
—
0
0
22
143
1.60
1.17
1.0
1.2
228.67
102.98
u/ml
—
8
54
118
1036
1.32
1.17
4.9
3.8
0.00
0.01
estimate
0.50
18
209
5
20
2.54
1.16
1.0
1.1
—
—
—
0
0
117
1028
1.31
1.14
4.9
3.7
0.00
7.22
estimate
0.50
18
225
8
41
1.99
1.10
1.3
1.2
—
—
—
0
0
7
33
2.16
1.06
1.3
1.5
—
—
—
0
0
7
33
2.16
1.06
1.3
1.5
—
—
—
0
0
54
431
1.34
1.02
2.6
2.2
—
—
—
0
0
115
1019
1.28
1.01
4.8
3.7
0.00
0.00
estimate
-0.00
18
218
18
116
1.60
1.00
1.1
1.1
—
—
—
0
0
193
1845
1.57
0.98
21.8
14.6
23.89
21.50
mg/l
0.36
158
1494
21
142
1.53
0.97
2.1
2.3
76.57
68.38
ml/min/173m2
—
7
56
50
401
1.32
0.92
1.6
1.7
—
—
—
0
0
60
496
1.29
0.89
1.2
1.3
2.26
1.16
u/ml
0.35
11
144
15
96
1.61
0.87
2.3
1.6
—
—
—
0
0
57
470
1.29
0.86
2.7
2.0
2.51
2.78
mg/l
0.61
49
408
44
350
1.33
0.86
4.3
3.4
224.29
272.63
ng/l
0.09
35
268
185
1763
1.41
0.85
5.1
5.1
5.85
5.87
mmol/l
0.08
173
1647
6
31
1.96
0.85
1.0
1.1
—
—
—
0
0
88
774
1.24
0.77
4.8
3.6
0.00
0.02
estimate
0.74
15
185
92
815
1.23
0.74
6.7
4.8
35.05
36.21
g/l
1.02
85
778
21
152
1.42
0.72
1.3
1.4
—
—
—
0
0
28
214
1.36
0.71
2.8
1.7
—
—
—
0
0
5
26
1.94
0.71
1.2
1.0
—
—
—
0
0
7
41
1.73
0.70
2.0
1.4
—
—
—
0
0
35
278
1.31
0.70
3.6
3.0
1.77
2.15
e6/l
0.20
13
126
10
62
1.64
0.66
3.0
1.9
—
—
—
0
0
180
1724
1.31
0.65
5.8
5.6
1.89
1.87
mu/l
0.11
169
1603
190
1835
1.37
0.63
5.1
5.1
4.61
4.70
mmol/l
0.56
178
1725
8
49
1.66
0.63
2.1
1.5
—
—
—
0
0
8
51
1.59
0.61
2.3
1.6
—
—
—
0
0
8
54
1.50
0.58
1.3
1.3
—
—
—
0
0
17
124
1.40
0.58
1.6
2.1
—
—
—
0
0
11
73
1.53
0.57
1.8
1.6
—
—
—
0
0
17
225
0.73
0.54
1.7
2.0
2.90
3.52
ratio
1.82
12
189
44
373
1.23
0.53
1.3
1.3
7.52
9.22
u/ml
0.13
19
148
191
1855
1.33
0.51
5.6
5.7
2.67
2.76
mmol/l
0.69
177
1740
155
1476
1.19
0.49
4.7
4.6
14.70
14.75
pmol/l
0.09
144
1363
77
694
1.17
0.49
3.7
3.6
23.45
26.55
ng/l
0.29
47
461
7
46
1.54
0.49
1.6
1.4
—
—
—
0
0
5
81
0.61
0.47
1.2
1.1
0.70
0.89
g/l
—
5
81
27
221
1.25
0.45
2.8
1.7
—
—
—
0
0
188
1828
1.27
0.45
5.0
5.0
1.47
1.48
mmol/l
0.10
173
1710
180
1743
1.23
0.44
4.4
4.2
1.31
1.29
mmol/l
0.10
164
1616
8
56
1.45
0.43
1.3
1.4
—
—
—
0
0
19
150
1.29
0.42
1.7
2.2
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
5
34
1.48
0.40
2.6
1.8
—
—
—
0
0
5
34
1.48
0.40
8.6
3.1
9.10
8.89
pmol/l
—
5
34
5
34
1.48
0.40
1.2
2.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
547.20
—
0
10
0
18
0.00
0.40
0.0
1.1
—
35.30
—
0
10
70
638
1.15
0.38
3.4
3.5
2.37
2.36
mmol/l
0.28
63
582
5
37
1.36
0.37
1.8
1.5
—
—
—
0
0
5
78
0.63
0.36
1.2
1.1
1.38
1.53
g/l
—
5
78
6
43
1.41
0.35
2.8
2.1
21.15
24.95
mmol/l
—
6
43
77
832
0.88
0.35
2.1
1.9
1.38
1.38
mmol/l
0.00
66
709
6
44
1.37
0.34
2.2
1.4
—
—
—
0
0
10
74
1.37
0.33
1.4
1.5
—
—
—
0
0
100
942
1.12
0.31
3.9
3.0
127.31
102.66
ug/l
0.74
92
892
22
259
0.83
0.30
1.8
2.2
—
—
—
0
0
37
328
1.16
0.29
1.6
1.5
—
—
—
0
0
7
57
1.24
0.29
1.4
1.1
—
—
—
0
0
13
103
1.28
0.29
1.3
1.4
—
—
—
0
0
5
71
0.70
0.26
2.0
1.5
—
—
—
0
0
59
545
1.11
0.26
1.8
1.6
16.11
21.78
nmol/l
3.39
53
461
92
871
1.10
0.25
3.4
2.7
—
—
estimate
—
0
0
180
1763
1.15
0.24
21.1
14.5
82.54
83.25
ml/min/173m2
0.16
168
1626
5
39
1.29
0.23
1.6
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
141.94
—
0
10
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
3.8
—
0.92
—
0
12
7
58
1.21
0.18
1.4
1.1
—
—
—
0
0
22
195
1.14
0.18
1.5
4.3
2.13
31.19
ug/l
0.75
15
163
39
361
1.10
0.17
3.2
4.4
27.30
22.00
%
0.67
17
162
90
864
1.07
0.17
2.7
2.6
74.63
77.39
nmol/l
0.45
82
785
17
191
0.88
0.14
4.7
3.4
—
—
—
0
0
128
1253
1.06
0.11
3.6
3.3
—
—
—
0
0
52
541
0.95
0.09
3.1
3.1
1148.89
1025.39
ng/l
0.17
46
449
6
56
1.07
0.08
2.2
1.9
—
—
—
0
0
6
58
1.04
0.08
1.3
1.3
—
—
—
0
0
10
88
1.14
0.08
1.4
1.4
—
—
—
0
0
20
215
0.92
0.08
3.5
4.8
31.71
32.35
%
0.08
14
144
20
186
1.08
0.07
8.2
6.7
—
—
—
0
0
71
691
1.04
0.07
5.5
3.2
33.26
31.56
u/l
0.19
66
661
132
1338
0.96
0.06
4.2
3.3
58.98
44.74
u/l
0.68
127
1274
25
237
1.06
0.06
7.3
7.5
105.00
104.10
mmol/l
0.85
25
237
61
594
1.04
0.06
4.3
3.9
25.50
9.08
mg/mmol
0.80
37
362
82
805
1.03
0.05
2.4
2.1
103.35
97.02
pmol/l
0.56
44
418
60
587
1.03
0.04
4.0
3.1
0.06
0.01
estimate
0.37
16
183
26
271
0.95
0.04
1.7
1.8
1.38
1.37
%
0.01
21
238
37
361
1.03
0.02
2.7
2.7
2.42
2.45
mmol/l
0.84
31
329
29
282
1.03
0.02
2.3
1.7
1163.59
1200.48
nmol/l
0.09
20
216
23
234
0.98
0.00
1.6
2.1
—
—
—
0
0
28
281
1.00
0.00
2.4
2.9
0.44
0.77
ug/l
1.84
17
165
174
1739
1.00
0.00
5.8
6.1
38.44
38.96
mmol/mol
0.43
163
1651
61
612
1.00
0.00
2.7
2.5
56.42
63.69
u/l
0.45
52
571
56
563
0.99
0.00
5.6
3.8
0.00
0.00
estimate
-0.00
14
208
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
7
0.00
-0.00
0.0
1.0
—
108.00
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
7.13
—
0
6
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.9
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.6
—
67.04
—
0
5
0
6
0.00
-0.00
0.0
2.3
—
43.02
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
80
1.00
-0.00
1.5
1.6
200.15
273.74
mu/l
—
8
75
Mortality – FinRegistry
↥Association
Association between endpoint AB1_TOXOPLASMOSIS and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_TOXOPLASMOSIS | 2.45 [1.73, 3.47] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.053 |
During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 345 males with AB1_TOXOPLASMOSIS died.
Mortality risk
Mortality risk for people of age
years, who have AB1_TOXOPLASMOSIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.459% |
| 5 | No data | 2.845% |
| 10 | No data | 7.235% |
| 15 | No data | 13.855% |
| 20 | No data | 23.599% |
Relationships between endpoints
↥Index endpoint: AB1_TOXOPLASMOSIS – Toxoplasmosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data