No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
858 |
4. Check minimum number of eventsNone |
858 |
5. Include endpointsNone |
858 |
6. Filter based on genotype QC (FinnGen only) |
742 |
Control definitions (FinnGen only)
- Control exclude
- AB1_SEQULEAE_OF_INFECTIONS_AND_PARASITES
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Sequelae of tuberculosis
based on the number of shared cases.
Similar with more cases:
- Sequelae of tuberculosis, including avohilmo
- Sequelae of infectious and parasitic diseases
- Sequelae of infectious and parasitic diseases, including avohilmo
- Certain infectious and parasitic diseases
- Certain infectious and parasitic diseases, including avohilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 12957 | 5086 | 7338 |
| Only index persons | 5957 | 2950 | 3007 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.20 | 0.15 | 0.21 |
| Only index persons | 0.11 | 0.11 | 0.11 |
| Median age at first event (years) | |||
| Whole population | 67.14 | 68.05 | 66.71 |
| Only index persons | 66.85 | 67.27 | 66.43 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 742 | 275 | 467 |
| Unadjusted period prevalence (%) | 0.17 | 0.10 | 0.21 |
| Median age at first event (years) | 66.57 | 63.64 | 68.29 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 772
- Matched controls
- 7720
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
B90.9
ICD-10 Finland
Sequelae of respiratory and unspecified tuberculosis
+∞
307.7
529
*
Y3409
ICD-8 Finland
Follow-up examination of illness, accident or surgery, Treated inactive pulmonary tuberculosis
59.1
97.6
55
10
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
4.1
78.9
321
1131
1370A
ICD-9 Finland
Late effects of tuberculosis, Late effects of respiratory or unspecified tuberculosis[HENGITYSELINTUBERKUL JÄLKITILA,TUBERKULOOSIARPI]
+∞
75.3
71
*
A15.0
ICD-10 Finland
Tuberculosis of lung, confirmed by sputum microscopy with or without culture
37.9
69.0
43
12
J96.1
ICD-10 Finland
Chronic respiratory failure
7.9
62.7
91
128
UGC12
NOMESCO Finland
Flexible bronchoscopy
4.4
56.7
169
463
1370X
ICD-9 Finland
Late effects of tuberculosis, Late effects of respiratory or unspecified tuberculosis[HENGITYSELINTUBERKUL JÄLKITILA,MUU JÄLKITILA]
+∞
53.8
51
*
J47
ICD-10 Finland
Bronchiectasis
9.2
53.2
67
79
01908
ICD-8 Finland
Late effects of tuberculosis, Sequelae aliae o tuberculosis organorum respirationis
+∞
52.7
50
*
R03AK06
ATC
salmeterol and fluticasone; inhalant
3.6
51.7
227
810
B90.0
ICD-10 Finland
Sequelae of central nervous system tuberculosis
+∞
51.6
49
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.8
51.4
193
621
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
3.4
51.3
250
953
01102
ICD-8 Finland
Pulmonary tuberculosis, Non cavernosa
21.5
49.0
37
18
R03BB01
ATC
ipratropium bromide; inhalant
4.1
44.2
141
402
R03DA04
ATC
theophylline; systemic, rectal
3.7
43.6
166
535
R03AC02
ATC
salbutamol; inhalant
2.8
41.8
458
2655
R03BB04
ATC
tiotropium bromide; inhalant
3.3
40.5
193
714
R03AK03
ATC
[U] fenoterol and ipratropium bromide
3.4
37.3
161
558
B90.2
ICD-10 Finland
Sequelae of tuberculosis of bones and joints
+∞
35.7
34
*
J45.9
ICD-10 Finland
Asthma, unspecified
2.9
34.4
210
886
J45.1
ICD-10 Finland
Nonallergic asthma
4.0
34.3
106
293
R03AC12
ATC
salmeterol; inhalant
3.8
32.5
108
314
R03BA01
ATC
beclometasone; inhalant
3.0
32.1
173
680
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.8
31.1
188
785
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
29.0
393
2378
A15.1
ICD-10 Finland
Tuberculosis of lung, confirmed by culture only
66.6
28.1
32
5
R03BA05
ATC
fluticasone; inhalant
2.7
26.5
173
746
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
3.3
26.4
108
358
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
6.6
26.3
43
68
4912B
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS OBSTRUCTIVA CUM EMPHYSEMATE]
5.7
25.5
49
91
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
4.2
24.8
70
180
H02AB06
ATC
prednisolone; systemic
2.2
23.9
417
2722
R04.2
ICD-10 Finland
Haemoptysis
3.9
22.0
67
182
4912A
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS CHRONICA OBSTRUCTIVA]
7.5
21.3
31
43
R03BA02
ATC
budesonide; inhalant
2.4
20.4
167
793
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
2.9
20.1
106
406
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
3.4
19.7
74
232
J45.8
ICD-10 Finland
Mixed asthma
4.7
19.1
45
100
4939X
ICD-9 Finland
Asthma, unspecified[ASTHMA BRONCHIALE NUD]
5.5
18.4
36
68
R03AC13
ATC
formoterol; inhalant
3.3
17.9
72
235
H02AB04
ATC
methylprednisolone; systemic
2.3
16.9
141
672
01904
ICD-8 Finland
Late effects of tuberculosis, Adhaesiones pleurae
+∞
16.7
16
*
TGC00
NOMESCO Finland
Bronchial lavation
4.7
16.3
38
84
J01AA02
ATC
doxycycline; systemic
2.0
16.2
583
4641
01909
ICD-8 Finland
Late effects of tuberculosis, Sequelae NUD o tuberculosis organorum respirationis
+∞
15.7
15
*
R03AK07
ATC
formoterol and budesonide; inhalant
2.2
14.9
137
678
A16.0
ICD-10 Finland
Tuberculosis of lung, bacteriologically and histologically negative
21.5
14.7
21
10
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.9
14.5
69
249
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.0
13.9
177
991
R03AC03
ATC
terbutaline; inhalant
2.3
13.9
115
544
R03DC03
ATC
montelukast; oral
2.3
13.8
110
511
B90.1
ICD-10 Finland
Sequelae of genitourinary tuberculosis
+∞
13.6
13
*
R03BB02
ATC
oxitropium bromide; inhalant
4.7
13.4
31
68
J01FA06
ATC
roxithromycin; oral
1.8
13.3
312
2123
0110A
ICD-9 Finland
Pulmonary tuberculosis, Tuberculosis of lung, infiltrative[TUBERCULOSIS PULMONUM INFILTRATIVA, BAKTER.VARMA]
40.8
13.2
16
*
B90.8
ICD-10 Finland
Sequelae of tuberculosis of other organs
+∞
12.5
12
*
J01MA14
ATC
moxifloxacin; systemic
2.4
12.5
93
419
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.1
12.4
54
185
49300
ICD-8 Finland
Asthma, bronchiale
3.7
12.3
39
109
R06.0
ICD-10 Finland
Dyspnoea
1.8
11.8
249
1631
01930
ICD-8 Finland
Late effects of tuberculosis, Columnae vertebralis
+∞
11.5
11
*
01901
ICD-8 Finland
Late effects of tuberculosis, Emphysema
+∞
11.5
11
*
A16.2
ICD-10 Finland
Tuberculosis of lung, without mention of bacteriological or histological confirmation
121.8
11.5
12
*
XG410
NOMESCO Finland
Flow-volume spirometry
3.2
11.4
45
145
R95
ICPC
Chron obstructive pulmonary disease
3.3
11.4
44
140
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
3.6
11.3
37
106
R05CB01
ATC
acetylcysteine; inhalant, oral
3.5
10.8
37
109
1370D
ICD-9 Finland
Late effects of tuberculosis, Late effects of respiratory or unspecified tuberculosis[HENGITYSELINTUBERKUL JÄLKITILA,PLEURAFIBROOSI]
+∞
10.4
10
*
1373X
ICD-9 Finland
Late effects of tuberculosis of bones and joints
+∞
10.4
10
*
A15.3
ICD-10 Finland
Tuberculosis of lung, confirmed by unspecified means
+∞
10.4
10
*
01107
ICD-8 Finland
Pulmonary tuberculosis, Suspecta
12.3
10.4
18
15
01101
ICD-8 Finland
Pulmonary tuberculosis, Cavernosa
23.7
10.3
14
6
J01MA12
ATC
levofloxacin; systemic
1.8
10.1
180
1113
7863A
ICD-9 Finland
Symptoms involving respiratory system and other chest symptoms, Haemoptysis
9.3
10.1
20
22
01210
ICD-8 Finland
Other respiratory tuberculosis, Tuberculosis pleurae, pleuritis exsudativa tuberculosa
40.6
10.0
12
*
49104
ICD-8 Finland
Chronic bronchitis, Cum emphysemate
4.9
9.6
21
44
H02AB07
ATC
prednisone; oral
1.9
9.6
139
806
78310
ICD-8 Finland
Symptoms referable to respiratory system, Haemoptysis
10.2
9.6
18
18
R03AK08
ATC
formoterol and beclometasone; inhalant
3.3
9.5
35
108
01903
ICD-8 Finland
Late effects of tuberculosis, Fibrosis pulmonum
+∞
9.4
9
*
01106
ICD-8 Finland
Pulmonary tuberculosis, Pulmonum alia sive NUD
+∞
9.4
9
*
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
3.6
9.3
30
85
1240
FHL
Bronchoscopy
3.5
9.1
31
91
A15.2
ICD-10 Finland
Tuberculosis of lung, confirmed histologically
50.6
8.7
10
*
01931
ICD-8 Finland
Late effects of tuberculosis, Coxae
+∞
8.3
8
*
01900
ICD-8 Finland
Late effects of tuberculosis, Bronchiectasia
+∞
8.3
8
*
01510
ICD-8 Finland
Tuberculosis of bones and joints, Of hip
+∞
8.3
8
*
J46
ICD-10 Finland
Status asthmaticus
3.2
7.9
30
95
Z03.0
ICD-10 Finland
Observation for suspected tuberculosis
10.2
7.6
14
14
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
3.0
7.5
33
114
4940A
ICD-9 Finland
Bronchiectasis[BRONCHIECTASIAE]
13.5
7.4
12
9
1370C
ICD-9 Finland
Late effects of tuberculosis, Late effects of respiratory or unspecified tuberculosis[HENGITYSELINTUBERKUL JÄLKITILA,BRONKIEKTASIAT]
+∞
7.3
7
*
01220
ICD-8 Finland
Other respiratory tuberculosis, Pleurisy with effusion without mention of cause
10.1
7.0
13
13
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
7.0
141
895
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
7.0
289
2178
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
2.7
6.9
36
137
R96
ICPC
Asthma
2.0
6.8
70
359
Y3429
ICD-8 Finland
Follow-up examination of illness, accident or surgery, Other inactive tuberculosis cases
40.4
6.8
8
*
0310A
ICD-9 Finland
Diseases due to other mycobacteria, Pulmonary
40.4
6.8
8
*
0110K, ,
ICD-8 Finland
40.4
6.8
8
*
R05
ICD-10 Finland
Cough
1.7
6.7
124
770
R03BA08
ATC
ciclesonide; inhalant
2.3
6.6
50
227
GD1AD
NOMESCO Finland
Thorax CT examination
2.3
6.6
50
228
J01CA04
ATC
amoxicillin; systemic
1.5
6.6
500
4251
J96.0
ICD-10 Finland
Acute respiratory failure
3.4
6.5
23
70
A15.9
ICD-10 Finland
Respiratory tuberculosis unspecified, confirmed bacteriologically and histologically
70.4
6.4
7
*
I27.9
ICD-10 Finland
Pulmonary heart disease, unspecified
6.0
6.3
16
27
Z02.4
ICD-10 Finland
Examination for driving licence
0.6
6.3
96
1545
51899
ICD-8 Finland
Bronchiectasis
11.1
6.3
11
10
J42
ICD-10 Finland
Unspecified chronic bronchitis
3.9
6.3
18
47
J01FA10
ATC
azithromycin; systemic
1.5
6.3
274
2081
1374X
ICD-9 Finland
Late effects of tuberculosis of other specified organs
+∞
6.3
6
*
A70
ICPC
Tuberculosis
26.9
6.2
8
*
L04AA13
ATC
[U] leflunomide
3.7
6.2
19
52
TPW99
NOMESCO Finland
Other minor surgical procedure on peripheral vessel or lymphatic system
4.0
6.2
17
43
A31.0
ICD-10 Finland
Pulmonary mycobacterial infection
8.7
6.1
12
14
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
2.3
6.1
47
216
R02
ICPC
Shortness of breath/dyspnoea
1.7
6.1
107
655
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
120
247
5.57
56.82
4.8
2.8
—
—
—
0
0
40
77
5.42
20.04
6.5
3.7
—
—
—
0
0
55
156
3.72
16.97
2.3
1.4
—
—
—
0
0
20
35
5.84
11.05
5.6
5.0
—
—
—
0
0
41
131
3.25
10.57
1.5
1.5
34.98
33.48
iu/ml
0.01
14
36
26
78
3.41
7.44
1.1
1.2
—
—
—
0
0
34
122
2.87
7.25
1.4
1.4
—
—
—
0
0
62
322
2.01
5.87
1.5
1.4
—
—
—
0
0
29
111
2.68
5.53
1.4
1.4
—
—
—
0
0
34
143
2.44
5.37
1.5
1.5
—
—
—
0
0
14
29
4.90
4.82
1.2
1.3
8.65
0.10
u/ml
—
9
19
33
145
2.33
4.77
1.4
1.5
—
—
—
0
0
119
803
1.57
4.59
6.7
6.1
2.88
1.13
mmol/l
3.83
106
639
26
105
2.53
4.50
1.4
1.5
—
—
—
0
0
55
318
1.79
3.83
1.8
1.8
2.50
2.61
ug/l
0.02
48
262
356
4112
0.75
3.76
4.9
5.0
1.45
1.43
mmol/l
0.24
322
3603
362
4162
0.75
3.65
4.9
5.1
4.24
4.29
mmol/l
0.34
329
3689
22
93
2.41
3.51
1.5
1.5
—
—
—
0
0
8
13
6.21
3.50
2.5
1.2
—
—
—
0
0
128
931
1.45
3.44
2.2
1.9
—
—
—
0
0
375
4263
0.77
3.33
7.8
7.3
41.06
41.16
mmol/mol
0.08
342
3833
163
1247
1.39
3.30
2.4
1.9
—
—
—
0
0
278
2316
1.31
3.20
4.1
3.6
2031.65
2331.65
ng/l
0.53
255
2028
345
3949
0.77
3.15
4.2
4.3
1.19
1.23
mmol/l
0.56
310
3412
13
45
2.92
3.03
1.2
1.6
—
—
—
0
0
13
45
2.92
3.03
1.5
1.5
—
—
—
0
0
13
45
2.92
3.03
1.5
1.5
—
—
—
0
0
13
45
2.92
3.03
1.5
1.5
—
—
—
0
0
121
892
1.42
3.03
2.2
1.9
—
—
—
0
0
58
370
1.61
2.87
4.7
4.0
3.20
2.04
mmol/l
0.95
46
271
383
4297
0.78
2.84
5.5
6.0
2.36
2.41
mmol/l
0.52
348
3784
29
154
1.92
2.69
1.4
1.4
—
—
—
0
0
444
4864
0.79
2.52
44.9
32.2
126.40
128.26
g/l
1.89
436
4755
444
4863
0.80
2.51
45.1
31.9
243.49
234.69
e9/l
1.96
436
4717
444
4863
0.80
2.51
44.7
31.9
4.21
4.26
e12/l
1.24
432
4700
444
4863
0.80
2.51
45.5
32.4
38.27
38.35
%
0.10
435
4750
444
4862
0.80
2.50
44.6
31.8
92.25
92.12
fl
0.21
437
4755
73
1021
0.69
2.46
4.6
3.6
3.18
2.52
e6/l
0.20
39
551
443
4848
0.80
2.46
38.9
29.0
88.18
89.31
umol/l
0.18
436
4734
121
1549
0.74
2.40
1.9
1.9
1.23
1.23
mmol/l
0.00
105
1238
440
4813
0.80
2.40
36.8
27.1
4.04
4.03
mmol/l
0.19
433
4673
440
4811
0.80
2.38
36.4
26.8
138.95
139.43
mmol/l
2.69
434
4677
5
8
6.28
2.37
1.0
1.5
—
—
—
0
0
325
2842
1.25
2.37
12.5
8.3
4.60
4.49
e9/l
0.32
298
2425
7
17
4.15
2.36
1.1
1.1
—
—
—
0
0
78
1067
0.70
2.33
4.5
3.4
1.80
1.31
e6/l
0.31
45
597
79
573
1.42
2.19
8.7
5.7
11.92
12.60
mmol/l
0.33
68
538
128
1010
1.32
2.11
3.4
2.6
20.37
20.73
%
0.11
123
930
24
131
1.86
2.10
4.9
5.0
101.79
104.87
mmol/l
1.90
24
119
16
75
2.16
2.09
1.5
1.5
—
—
—
0
0
135
1077
1.31
2.06
3.3
2.5
2.28
2.20
g/l
0.88
128
982
7
20
3.52
2.06
1.0
1.1
—
—
—
0
0
431
4685
0.82
2.02
16.2
12.4
21.43
22.74
u/l
1.32
417
4479
11
44
2.52
2.02
1.3
1.6
—
—
—
0
0
30
178
1.71
2.01
2.4
1.5
—
—
—
0
0
86
644
1.38
2.00
7.9
6.9
120.78
118.48
g/l
0.48
86
630
385
4225
0.82
1.96
5.5
5.2
2.03
2.08
mu/l
0.35
354
3727
14
64
2.21
1.95
1.4
1.4
13.00
13.51
u/l
0.16
14
59
35
220
1.62
1.91
3.1
3.3
4.33
2.61
ratio
0.48
27
133
142
1154
1.28
1.89
3.4
2.5
11.17
11.27
umol/l
0.06
133
1058
0
52
0.00
1.88
0.0
1.6
—
—
—
0
0
390
4261
0.83
1.85
28.3
22.0
68.86
66.73
ml/min/173m2
1.20
362
4002
400
4350
0.83
1.76
5.4
5.6
6.10
6.18
mmol/l
0.51
356
3792
6
19
3.17
1.66
2.3
1.7
—
—
—
0
0
13
62
2.12
1.66
1.7
1.7
—
—
—
0
0
21
121
1.76
1.59
1.4
1.3
1.13
1.15
g/l
0.12
21
116
10
43
2.34
1.59
1.4
1.3
—
—
—
0
0
10
43
2.34
1.59
1.4
1.3
—
—
—
0
0
105
843
1.28
1.55
6.8
4.7
1.07
1.04
mmol/l
0.52
94
758
36
241
1.52
1.55
3.0
3.5
60.18
78.13
mg/l
0.30
30
209
39
266
1.49
1.54
2.0
1.9
—
—
—
0
0
8
33
2.44
1.54
3.1
3.5
1.25
0.58
%
—
8
33
197
1701
1.21
1.52
2.8
2.5
64.14
62.54
u/l
0.07
185
1569
36
242
1.51
1.52
3.0
3.5
34.58
50.52
mg/l
0.75
30
211
78
604
1.32
1.50
3.4
2.5
65.71
65.44
g/l
0.10
69
537
118
968
1.26
1.47
4.6
2.7
0.80
0.82
mmol/l
0.62
109
899
317
3482
0.85
1.46
4.5
4.0
15.67
15.24
pmol/l
2.04
292
3039
11
52
2.13
1.45
1.9
1.4
—
—
—
0
0
14
73
1.93
1.44
1.7
1.5
—
—
—
0
0
435
4654
0.85
1.44
32.5
21.7
30.13
29.58
mg/l
0.13
404
4083
48
349
1.40
1.38
11.2
7.9
15.31
15.42
%
0.10
48
335
5
17
2.95
1.36
1.2
1.3
0.96
0.95
nmol/l
—
5
12
89
1098
0.79
1.35
3.7
3.5
0.76
0.89
ug/l
0.94
65
785
100
815
1.26
1.33
4.9
3.5
241.39
251.42
u/l
0.51
95
764
115
1375
0.81
1.32
3.1
3.2
2.46
2.47
mmol/l
0.36
100
1211
173
1496
1.20
1.31
3.1
2.9
29.68
35.02
u/l
1.27
167
1403
17
99
1.73
1.28
1.5
1.6
—
—
—
0
0
79
631
1.28
1.24
1.4
1.3
17.25
8.80
u/ml
0.44
35
209
6
25
2.41
1.24
1.0
3.6
77.67
175.96
nmol/l
—
6
25
22
139
1.60
1.24
1.2
1.6
9505.86
16674.57
e6/l
0.61
14
92
34
238
1.45
1.22
1.8
1.7
—
—
—
0
0
5
19
2.64
1.21
1.6
1.4
0.32
0.11
nmol/l
—
5
11
173
1972
0.84
1.21
5.3
6.1
3.28
6.38
ug/l
0.70
154
1703
6
26
2.32
1.19
1.8
1.5
—
—
—
0
0
6
26
2.32
1.19
1.8
1.5
—
—
—
0
0
6
26
2.32
1.19
1.8
1.5
—
—
—
0
0
6
26
2.32
1.19
1.8
1.5
—
—
—
0
0
78
628
1.27
1.16
5.1
3.4
284.18
316.37
ng/l
0.33
71
579
22
142
1.57
1.15
6.6
4.6
5.15
5.07
kpa
0.16
22
137
5
20
2.51
1.15
2.0
1.5
—
—
—
0
0
5
20
2.51
1.15
2.0
1.5
—
—
—
0
0
5
20
2.51
1.15
1.0
1.1
—
—
—
0
0
42
310
1.38
1.14
5.3
4.1
1.75
1.55
%
0.72
42
291
25
167
1.51
1.13
1.4
1.4
—
—
—
0
0
25
167
1.51
1.13
1.4
1.4
—
—
—
0
0
5
21
2.39
1.09
3.2
1.6
—
—
—
0
0
51
654
0.76
1.07
13.2
9.9
—
—
—
0
0
154
1751
0.85
1.04
4.5
3.8
0.81
0.48
e6/l
0.47
133
1358
16
98
1.65
1.04
1.4
1.6
—
—
—
0
0
198
2203
0.86
1.01
5.0
4.5
126.14
139.25
e6/l
0.08
161
1654
182
2037
0.86
1.01
4.5
3.8
19.46
132.65
e6/l
2.75
159
1616
15
93
1.63
0.94
1.1
1.1
—
—
—
0
0
163
1828
0.86
0.92
2.4
2.1
212.81
278.65
u/l
0.47
156
1705
9
52
1.74
0.92
1.4
1.2
—
—
—
0
0
20
134
1.51
0.92
2.7
2.5
54.00
90.48
ug/min
0.60
14
81
136
1546
0.85
0.92
4.7
5.1
21.21
22.38
%
0.36
72
839
83
695
1.22
0.91
1.3
1.3
31.73
35.75
iu/ml
0.17
31
228
12
71
1.70
0.89
1.4
1.4
—
—
—
0
0
8
45
1.79
0.84
1.8
1.4
—
—
—
0
0
174
1927
0.87
0.83
2.0
1.9
20.87
19.91
nmol/l
0.29
152
1608
35
267
1.33
0.82
1.3
1.3
—
—
—
0
0
6
32
1.88
0.82
1.3
1.3
106.00
92.88
pmol/l
—
6
32
47
375
1.27
0.80
1.7
1.5
—
—
—
0
0
10
59
1.70
0.76
1.0
1.2
—
—
—
0
0
15
100
1.51
0.73
1.0
1.1
—
28.15
—
0
6
5
25
2.01
0.72
1.0
1.2
—
—
—
0
0
31
399
0.77
0.72
4.4
3.4
25.68
24.00
mmol/l
2.15
31
393
24
178
1.36
0.69
1.3
1.5
—
—
—
0
0
326
3077
1.10
0.67
9.5
6.7
1.21
1.21
mmol/l
0.07
288
2604
7
44
1.60
0.65
1.0
1.2
58.57
74.60
u/l
—
7
35
45
369
1.23
0.64
1.9
1.7
1.45
1.53
g/l
0.21
39
334
13
87
1.50
0.63
1.5
1.6
—
—
—
0
0
60
508
1.20
0.63
3.0
3.7
89.55
97.02
ng/l
0.30
45
428
10
63
1.60
0.62
1.2
1.0
—
—
u/ml
—
0
0
52
436
1.21
0.61
4.7
2.9
119.85
124.03
g/l
0.78
52
423
309
2923
1.10
0.60
7.6
5.9
10.86
12.87
umol/l
3.06
299
2760
191
2059
0.90
0.58
3.4
3.3
2.31
2.35
mmol/l
3.69
171
1821
6
35
1.72
0.57
2.0
1.5
—
—
—
0
0
52
610
0.84
0.55
3.8
5.1
37.48
33.33
%
1.06
31
355
6
37
1.63
0.55
2.0
1.5
—
—
—
0
0
258
2736
0.91
0.55
2.5
2.4
89.52
92.43
pmol/l
0.42
139
1448
167
1805
0.90
0.53
4.4
4.0
10.68
9.21
mg/mmol
0.15
121
1162
6
39
1.54
0.53
2.5
2.4
—
—
—
0
0
97
870
1.13
0.51
1.3
1.2
1.07
1.08
u/ml
0.01
27
203
11
156
0.70
0.50
2.5
2.1
2.17
1.94
mg/l
0.32
11
128
10
67
1.50
0.50
1.5
1.2
—
—
—
0
0
20
257
0.77
0.50
1.4
3.2
297.64
12173.08
u/ml
0.61
14
216
19
146
1.31
0.47
1.4
1.3
—
—
—
0
0
24
298
0.80
0.46
1.3
2.2
9.50
11.12
nmol/l
0.40
19
256
355
3690
0.93
0.45
6.7
5.9
32.50
3216.79
e6/l
—
8
78
21
166
1.27
0.43
1.2
1.0
—
—
—
0
0
131
1211
1.10
0.42
5.4
5.2
1.02
1.02
kg/l
0.56
95
832
5
32
1.57
0.42
12.0
3.8
1.20
0.84
index
—
5
32
23
185
1.25
0.42
1.1
1.1
214.46
118.03
u/ml
—
7
59
51
445
1.16
0.42
2.2
1.8
389.22
401.72
nmol/l
0.15
45
398
69
616
1.13
0.41
3.1
2.7
10.92
6.18
ug/l
0.35
56
514
11
79
1.40
0.41
1.0
1.3
—
—
—
0
0
264
2518
1.07
0.40
5.7
4.7
73.15
86.67
ng/l
0.16
231
2037
220
2085
1.08
0.40
3.0
2.4
—
—
—
0
0
164
1747
0.92
0.39
3.5
3.3
6.48
6.79
mmol/l
0.49
140
1424
122
1314
0.92
0.38
3.4
2.5
—
—
—
0
0
29
243
1.20
0.38
4.4
3.4
1.63
1.45
mmol/l
0.31
29
238
58
516
1.13
0.37
2.2
1.7
—
—
—
0
0
5
37
1.35
0.37
1.2
1.8
—
—
—
0
0
244
2329
1.07
0.37
2.9
2.4
84.19
79.93
nmol/l
1.23
213
2011
168
1582
1.08
0.36
5.2
4.7
0.00
0.00
estimate
0.50
63
535
192
1818
1.07
0.36
2.5
2.4
3.25
3.12
mg/l
0.29
170
1541
11
82
1.35
0.34
1.3
1.1
—
—
—
0
0
11
83
1.33
0.32
6.2
5.5
12.99
13.43
mg/l
0.12
11
75
7
96
0.73
0.31
2.1
1.2
347.71
527.60
mg/l
—
7
91
7
53
1.32
0.31
2.0
1.6
—
—
—
0
0
7
54
1.30
0.30
1.1
1.0
—
—
—
0
0
213
2040
1.06
0.29
5.8
5.0
0.04
0.07
estimate
0.38
56
511
8
108
0.74
0.29
1.8
1.6
—
—
—
0
0
76
700
1.10
0.29
3.8
3.9
73.28
29.94
ug/l
0.41
70
600
9
116
0.77
0.27
1.0
1.3
—
—
—
0
0
20
169
1.19
0.26
6.9
4.1
1.08
1.51
index
0.31
12
91
46
507
0.90
0.25
2.4
2.4
29.10
33.08
u/l
0.64
40
420
235
2271
1.05
0.24
3.9
3.1
166.97
148.84
ug/l
0.43
221
2041
372
3635
1.05
0.23
7.1
4.3
19.62
16.65
mm/h
2.13
353
3289
5
40
1.25
0.22
1.0
1.1
—
—
—
0
0
15
178
0.84
0.22
5.5
3.5
9.10
7.98
mmol/l
0.99
15
173
5
41
1.22
0.22
5.6
3.6
85.40
112.52
u/ml
—
5
41
0
11
0.00
0.21
0.0
1.1
—
132.57
—
0
11
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
100.09
—
0
11
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
27
239
1.13
0.21
3.3
2.3
0.22
0.36
iu/ml
3.01
17
141
0
12
0.00
0.21
0.0
1.7
—
1.44
—
0
5
0
14
0.00
0.20
0.0
1.1
—
102.96
—
0
14
16
136
1.18
0.20
1.9
1.5
—
—
—
0
0
52
481
1.09
0.20
1.9
1.8
—
—
—
0
0
66
617
1.08
0.20
4.4
2.9
4.14
4.27
kpa
0.28
61
595
115
1098
1.06
0.19
2.4
1.7
1.72
1.60
mg/l
0.15
100
890
230
2365
0.96
0.18
3.6
2.9
—
—
estimate
—
0
0
62
660
0.93
0.17
4.5
4.1
—
—
—
0
0
18
157
1.15
0.17
1.6
1.4
5.42
10.55
iu/ml
—
5
40
316
3099
1.03
0.16
21.6
21.9
1.39
1.44
inr
0.67
276
2646
148
1433
1.04
0.15
5.4
4.4
0.00
0.11
estimate
1.19
54
471
36
386
0.93
0.13
1.5
1.4
—
—
—
0
0
143
1389
1.04
0.12
1.9
1.8
472.25
5163490.98
pmol/l
0.50
118
1104
41
387
1.06
0.11
3.4
3.1
57.67
54.88
ml/min/173m2
0.16
15
183
33
352
0.93
0.10
1.3
1.4
—
—
—
0
0
151
1474
1.03
0.10
3.3
2.8
6.77
5.25
e6/l
0.51
144
1343
274
2698
1.02
0.10
5.6
4.7
0.00
0.00
estimate
-0.00
72
612
5
44
1.14
0.10
1.2
1.4
—
—
—
0
0
5
44
1.14
0.10
1.2
1.4
—
—
—
0
0
278
2745
1.02
0.08
5.6
4.8
0.00
0.50
estimate
0.51
73
606
7
64
1.09
0.08
1.6
1.4
—
—
—
0
0
73
707
1.04
0.08
5.0
3.4
3.23
1.93
mmol/l
2.10
68
580
7
65
1.08
0.08
1.3
1.6
—
20.83
—
0
12
141
1382
1.02
0.08
4.3
2.9
354.44
369.75
umol/l
0.83
125
1153
16
174
0.92
0.07
1.1
1.2
—
—
—
0
0
8
75
1.07
0.07
1.5
1.7
23.76
4.64
mg/l
—
8
59
12
108
1.11
0.07
1.3
1.2
27.74
42.11
u/l
0.50
12
95
12
108
1.11
0.07
5.1
2.2
186.83
214.10
%
0.75
12
103
41
393
1.05
0.07
8.8
7.1
25.87
24.82
mmol/l
0.96
41
388
9
100
0.90
0.06
7.6
2.7
17.87
12.82
pmol/l
—
9
100
273
2704
1.01
0.05
5.6
4.7
33.08
34.01
g/l
1.94
254
2486
26
247
1.05
0.05
2.8
2.0
279.40
416.77
ug/l
0.46
26
234
278
2755
1.01
0.05
9.4
6.1
1.21
1.21
mmol/l
0.43
261
2493
275
2731
1.01
0.03
5.6
4.8
0.00
5.48
estimate
0.80
77
640
14
131
1.07
0.03
4.8
2.0
3.01
3.67
g/l
1.49
14
122
143
1446
0.99
0.03
1.9
1.8
1171.89
1159.16
nmol/l
0.06
112
1074
263
2641
0.99
0.01
3.6
3.1
44.19
58.69
u/l
2.08
247
2394
25
257
0.97
0.01
3.2
2.6
1.90
0.79
g/l
0.25
20
218
15
154
0.97
0.00
1.1
1.2
—
—
—
0
0
15
153
0.98
0.00
1.1
1.2
—
—
—
0
0
129
1285
1.00
0.00
6.5
4.4
125.69
243.23
ng/l
0.67
117
1160
15
149
1.01
0.00
2.2
1.4
253.22
272.67
ug/g
—
9
88
330
3298
1.00
0.00
7.4
5.0
6.95
6.93
mmol/l
0.06
320
3159
391
3911
1.00
0.00
10.9
7.9
79.90
84.47
u/l
1.40
375
3653
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
94.00
—
0
8
0
6
0.00
-0.00
0.0
1.2
—
75.00
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
6
62
0.97
-0.00
1.7
1.4
—
—
—
0
0
6
60
1.00
-0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
7.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
1.16
—
0
7
0
6
0.00
-0.00
0.0
3.7
—
105.42
—
0
6
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
6
61
0.98
-0.00
1.7
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
13.94
—
0
5
6
61
0.98
-0.00
1.7
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
53
0.94
-0.00
1.4
1.5
—
57.14
—
0
7
6
63
0.95
-0.00
1.7
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
7
0.00
-0.00
0.0
1.6
—
94.14
—
0
7
0
7
0.00
-0.00
0.0
8.4
—
5.54
—
0
7
6
66
0.91
-0.00
2.3
2.8
—
—
—
0
0
5
56
0.89
-0.00
1.4
1.6
—
344.44
—
0
9
6
62
0.97
-0.00
1.7
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint AB1_SEQULAE_TUBERCU and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_SEQULAE_TUBERCU | 1.853 [1.65, 2.08] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.197 |
During the follow-up period (1.1.1998 — 31.12.2019), 1167 out of 2052 females with AB1_SEQULAE_TUBERCU died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_SEQULAE_TUBERCU | 1.985 [1.74, 2.26] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 1711 out of 2517 males with AB1_SEQULAE_TUBERCU died.
Mortality risk
Mortality risk for people of age
years, who have AB1_SEQULAE_TUBERCU.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.13% | 0.327% |
| 5 | 0.906% | 2.259% |
| 10 | 2.454% | 5.349% |
| 15 | 4.857% | 10.109% |
| 20 | 8.247% | 17.206% |
Relationships between endpoints
↥Index endpoint: AB1_SEQULAE_TUBERCU – Sequelae of tuberculosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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