Other bacterial agents as the cause of diseases classified to other chapters

AB1_OTHER_BACT_INOTHER

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 B96
  • Cause of death: ICD-10 B96

2 out of 7 registries used, show all original rules.

448

4. Check minimum number of events

None

448

5. Include endpoints

None

448

6. Filter based on genotype QC (FinnGen only)

385

Control definitions (FinnGen only)

Control exclude
AB1_BACT_BIR_OTHER_INF_AGENTS

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3169 1962 1175
Only index persons 2334 1415 919
Unadjusted period prevalence (%)
Whole population 0.05 0.06 0.03
Only index persons 0.05 0.05 0.04
Median age at first event (years)
Whole population 62.07 63.04 60.18
Only index persons 53.67 53.02 54.69

-FinnGen-

Key figures

All Female Male
Number of individuals 385 225 160
Unadjusted period prevalence (%) 0.08 0.08 0.07
Median age at first event (years) 59.14 55.22 64.66

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
396
Matched controls
3960
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
B96.2
ICD-10 Finland
Escherichia coli [E. coli] as the cause of diseases classified to other chapters
+∞
155.8
139
*
B96.5
ICD-10 Finland
Pseudomonas (aeruginosa) as the cause of diseases classified to other chapters
+∞
106.1
97
*
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
8.9
103.0
185
356
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
15.0
88.7
86
72
B96.1
ICD-10 Finland
Klebsiella pneumoniae [K. pneumoniae] as the cause of diseases classified to other chapters
+∞
57.7
54
*
A41.9
ICD-10 Finland
Sepsis, unspecified
10.7
52.4
61
66
A41.8
ICD-10 Finland
Other specified sepsis
15.7
50.1
45
32
J01MA02
ATC
ciprofloxacin; systemic
4.2
43.5
244
1092
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.2
43.1
111
278
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
15.7
40.4
36
25
J01MA12
ATC
levofloxacin; systemic
4.3
39.8
141
451
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
4.1
35.3
132
435
R50.9
ICD-10 Finland
Fever, unspecified
4.1
35.1
125
397
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
13.2
33.7
33
27
TK800
NOMESCO Finland
Hemodialysis
13.8
33.5
32
25
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.8
26.8
100
323
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
5.2
26.7
60
131
B03XA02
ATC
darbepoetin alfa; parenteral
11.1
26.5
29
28
B96.80
ICD-10 Finland
Campylo bacterial infection causing disease classified in other paragraph
+∞
26.3
25
*
A11CC03
ATC
alfacalcidol; systemic
8.8
24.7
32
39
J47
ICD-10 Finland
Bronchiectasis
9.5
24.5
30
34
B96.88
ICD-10 Finland
Other specified bacterial agents as the cause of diseases classified to other chapters
243.5
22.9
23
*
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
5.0
22.4
52
116
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
7.6
22.4
33
47
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.9
21.8
158
747
J01GB01
ATC
tobramycin; inhalant, parenteral
221.2
20.8
21
*
C03CA01
ATC
furosemide; systemic
2.7
20.6
178
916
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.1
19.8
104
409
127
Kela drug reimbursment
Transplant complication
17.9
19.5
30
18
TPH04
NOMESCO Finland
Cathetrisation of vein
2.8
19.5
127
563
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
4.5
19.2
51
127
B99
ICD-10 Finland
Other and unspecified infectious diseases
7.4
18.0
27
39
B96.0
ICD-10 Finland
Mycoplasma pneumoniae [M. pneumoniae] as the cause of diseases classified to other chapters
+∞
17.8
17
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.8
17.3
110
477
J01EA01
ATC
trimethoprim; systemic
2.6
17.3
147
738
J01MA14
ATC
moxifloxacin; systemic
3.6
17.1
63
198
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
6.5
16.6
28
46
ZX120
NOMESCO Finland
Intravenous
3.4
16.4
67
225
J01FF01
ATC
clindamycin; systemic
2.5
16.1
135
670
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
4.4
15.7
42
105
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
4.2
14.8
41
105
L04AA06
ATC
mycophenolic acid; systemic
11.5
14.7
27
25
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.5
14.6
54
170
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
4.4
14.5
38
93
UKC02
NOMESCO Finland
Cystoscopy
2.7
14.3
89
379
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.3
14.3
225
1451
TQW11
NOMESCO Finland
Vacuum treatment of wound
6.7
14.3
23
36
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.8
13.8
45
130
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.5
13.7
106
501
J01XB01
ATC
colistin; inhalant, parenteral
144.8
13.5
14
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.4
13.2
126
654
Z49.1
ICD-10 Finland
Extracorporeal dialysis
17.5
13.1
20
12
N30.9
ICD-10 Finland
Cystitis, unspecified
3.5
13.1
48
150
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.2
13.0
168
988
L04AA01
ATC
[U] ciclosporin
23.5
13.0
18
8
B96.7
ICD-10 Finland
Clostridium perfringens [C. perfringens] as the cause of diseases classified to other chapters
134.1
12.5
13
*
L04AX01
ATC
azathioprine; systemic
4.9
12.3
28
61
WX882
NOMESCO Finland
High dependency care
5.5
12.2
24
46
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
4.7
12.1
29
66
Z94.0
ICD-10 Finland
Kidney transplant status
22.1
12.1
17
8
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.4
12.1
46
147
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.9
12.1
63
243
J01MA06
ATC
norfloxacin; oral
2.7
12.0
76
324
GD1AD
NOMESCO Finland
Thorax CT examination
3.6
11.9
42
128
Z49.0
ICD-10 Finland
Preparatory care for dialysis
19.7
11.7
17
9
M04AA01
ATC
allopurinol; systemic
2.7
11.7
72
303
Z3231
NOMESCO Finland
Registered nurse
2.2
11.2
136
773
L04AD01
ATC
ciclosporin; systemic
10.5
11.1
21
21
H02AB07
ATC
prednisone; oral
2.6
11.0
72
312
N03AX16
ATC
[U] pregabalin
2.3
10.9
109
571
H02AB04
ATC
methylprednisolone; systemic
2.6
10.8
74
327
WW500
NOMESCO Finland
Blood transfusion
4.0
10.8
32
86
WX872
NOMESCO Finland
Intensive care
4.0
10.8
32
86
J01XE01
ATC
nitrofurantoin; oral
5.6
10.5
20
37
H02AB06
ATC
prednisolone; systemic
2.0
10.4
206
1389
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.9
10.3
52
196
L28
ICPC
Limited function/disability (L)
2.3
10.3
98
502
ZXE20
NOMESCO Finland
More than three and less than five hours
2.5
10.1
71
317
A12AA04
ATC
calcium carbonate; oral
10.4
10.1
19
19
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.0
10.1
222
1548
J01MA01
ATC
ofloxacin; systemic
2.9
10.0
50
188
TPX10
NOMESCO Finland
Implantation of vascular injection port
4.6
9.9
24
55
L89
ICD-10 Finland
Decubitus ulcer and pressure area
7.7
9.8
22
30
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.2
9.8
98
511
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
9.6
137
817
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.6
9.6
62
266
ZXD05
NOMESCO Finland
Urgent procedure
2.0
9.6
133
787
XF400
NOMESCO Finland
ECG with 12 standard connections
2.3
9.5
84
416
N18.0
ICD-10 Finland
End-stage renal disease
18.1
9.5
14
8
WW200
NOMESCO Finland
Immunization
5.3
9.5
19
37
A07AA09
ATC
vancomycin; oral
12.8
9.4
16
13
JN4BD
NOMESCO Finland
Extensive body CT
2.6
9.2
57
239
J01DC02
ATC
cefuroxime; systemic
3.6
9.1
31
92
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
16.1
9.1
14
9
TKC20
NOMESCO Finland
Catheterisation of bladder
3.0
9.1
42
151
JN3AD
NOMESCO Finland
Abdominal CT examination
2.4
9.0
65
294
137
Kela drug reimbursment
Uraemia requiring dialysis
19.1
9.0
13
7
Z49.2
ICD-10 Finland
Other dialysis
24.7
9.0
12
5
A46
ICD-10 Finland
Erysipelas
2.4
8.9
69
322
R03AK08
ATC
formoterol and beclometasone; inhalant
3.7
8.8
28
79
N18.8
ICD-10 Finland
Other chronic renal failure
6.9
8.8
21
32
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.8
8.7
47
184
3AC01, ,
NOMESCO Finland
16.7
8.6
13
8
WX892
NOMESCO Finland
Monitored bed care
2.9
8.6
42
156
J01DA01
ATC
[U] cefalexin
1.9
8.5
249
1866
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
20.6
8.5
12
6
J45.1
ICD-10 Finland
Nonallergic asthma
2.9
8.5
42
157
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
8.1
8.5
18
23
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
4.1
8.5
23
58
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
91.9
8.4
9
*
A10AB05
ATC
insulin aspart; parenteral
2.8
8.4
45
175
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.7
8.4
27
77
XW000
NOMESCO Finland
Bone marrow biopsy
3.6
8.4
28
82
A07AA02
ATC
nystatin; oral
3.2
8.4
34
113
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.9
8.2
39
142
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.1
8.2
89
477
KA1AE
NOMESCO Finland
Kidney ultrasound examination
4.9
8.2
18
38
TQW80
NOMESCO Finland
Local dermatologic skincare
4.9
8.2
18
38
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.9
8.2
159
1043
Z2446
NOMESCO Finland
Social worker
2.8
8.1
43
167
C03DA01
ATC
spironolactone; oral
2.3
8.0
65
309
TPH40
NOMESCO Finland
Insertion of a long peripheral venous catheter
13.4
7.9
13
10
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
8.7
7.9
16
19
N05CF01
ATC
zopiclone; oral
1.9
7.9
142
908
L04AD02
ATC
tacrolimus; systemic
11.1
7.9
14
13
ZXE10
NOMESCO Finland
More than one and less than three hours
1.9
7.8
149
969
N30.0
ICD-10 Finland
Acute cystitis
2.1
7.8
83
441
N18.5
ICD-10 Finland
Chronic kidney disease, stage 5
15.4
7.8
12
8
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.2
7.7
73
370
UJF32
NOMESCO Finland
Coloscopy
2.0
7.7
111
658
A10AC01
ATC
insulin (human); parenteral
2.6
7.7
45
184
N12
ICD-10 Finland
Tubulo-interstitial nephritis, not specified as acute or chronic
6.4
7.6
19
31
N02AX02
ATC
tramadol; systemic, rectal
1.8
7.6
175
1204
ZXE00
NOMESCO Finland
One hour or less
1.8
7.4
161
1086
TPH05
NOMESCO Finland
Open cannulation of peripheral vein
11.2
7.3
13
12
U88
ICD-10 Finland
Agent resistant to multiple antibiotics
+∞
7.3
7
*
QBG00
NOMESCO Finland
Debridement of bedsore of trunk
+∞
7.3
7
*
R32
ICD-10 Finland
Unspecified urinary incontinence
4.4
7.3
18
42
H02AB09
ATC
hydrocortisone; systemic
4.4
7.3
18
42
WZC00
NOMESCO Finland
Treatment plan or consultation
1.8
7.3
158
1065
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
4.1
7.2
20
51
N06AB04
ATC
citalopram; systemic
2.0
7.2
90
506
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
20.5
7.2
10
5
B05DA
ATC
Isotonic solutions
20.5
7.2
10
5
JN4AD
NOMESCO Finland
Body CT examination
2.3
7.1
56
262
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.5
7.1
47
203
K29.5
ICD-10 Finland
Chronic gastritis, unspecified
4.3
7.1
18
43
UDC00
NOMESCO Finland
Ear microscopy
2.6
7.0
42
173
R03AK11
ATC
formoterol and fluticasone; inhalant
5.6
7.0
19
35
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.4
7.0
51
231
J02AC01
ATC
fluconazole; systemic
1.8
6.9
152
1024
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.4
6.9
47
207
B03XA01
ATC
erythropoietin; parenteral
11.2
6.8
12
11
A02BC01
ATC
omeprazole; systemic
1.8
6.7
118
742
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
23.0
6.7
9
*
QBB99
NOMESCO Finland
Other procedure for wound of skin of trunk
23.0
6.7
9
*
K57.0
ICD-10 Finland
Diverticular disease of small intestine with perforation and abscess
23.0
6.7
9
*
Q61.2
ICD-10 Finland
Polycystic kidney, autosomal dominant
23.0
6.7
9
*
G04AC01, ,
ATC
3.6
6.7
22
64
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
12.5
6.6
11
9
J45.9
ICD-10 Finland
Asthma, unspecified
2.0
6.5
86
492
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
4.1
6.5
18
46
B01AB05
ATC
enoxaparin; parenteral
1.8
6.5
132
866
N05BA04
ATC
oxazepam; oral
1.8
6.5
116
732
J20.8
ICD-10 Finland
Acute bronchitis due to other specified organisms
70.9
6.4
7
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.2
6.4
55
267
N05CD07
ATC
temazepam; oral
2.2
6.4
59
295
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.3
6.4
24
76
J01DB01
ATC
cefalexin; oral
2.0
6.3
322
2733
Z3226
NOMESCO Finland
Physiotherapist
2.0
6.3
83
474
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
2.9
6.3
29
104
ZXD40
NOMESCO Finland
Procedure on patient requiring isolation
27.1
6.2
8
*
J41.1
ICD-10 Finland
Mucopurulent chronic bronchitis
27.1
6.2
8
*
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
3.3
6.2
23
72
L03AA02
ATC
filgrastim; parenteral
3.6
6.2
20
57
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.8
6.2
124
807
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
2.8
6.2
32
122
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.8
6.2
30
111
TKC10
NOMESCO Finland
Percutaneous puncture of bladder
7.9
6.2
13
17
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
12.8
6.1
10
8
D64.9
ICD-10 Finland
Anaemia, unspecified
2.2
6.1
53
259
R4110
NOMESCO Finland
Physiotherapy
1.8
6.1
118
762
L27.0
ICD-10 Finland
Generalized skin eruption due to drugs and medicaments
10.2
6.1
11
11
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.1
6.0
60
309
A03FA01
ATC
metoclopramide; systemic, rectal
1.9
6.0
96
583

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
218
964
3.81
38.16
13.2
4.3
—
—
—
0
0
36
54
7.23
23.35
10.5
2.5
—
—
—
0
0
103
411
3.04
19.09
3.3
1.8
—
—
—
0
0
121
533
2.83
18.67
3.8
2.0
—
—
—
0
0
127
574
2.79
18.66
8.7
4.0
0.81
0.82
mmol/l
0.33
118
547
123
549
2.80
18.49
5.2
2.4
2.12
2.32
g/l
3.11
112
505
117
516
2.80
17.93
5.5
2.4
17.82
22.37
%
3.77
112
487
197
1134
2.47
17.24
15.7
6.5
—
—
—
0
0
78
288
3.13
16.36
3.7
2.7
9.73
10.27
g/l
0.55
72
268
242
1587
2.35
15.02
16.1
6.7
0.62
0.66
%
0.72
231
1494
242
1592
2.34
14.84
16.0
6.8
8.83
8.79
%
0.07
231
1508
120
585
2.51
14.66
5.4
2.5
8.97
13.03
umol/l
12.22
115
545
97
429
2.67
14.47
3.8
3.1
1.97
1.81
%
0.42
83
391
241
1596
2.30
14.36
15.8
6.6
2.56
2.87
%
1.37
230
1504
232
1518
2.28
14.15
11.6
5.1
32.68
35.61
g/l
9.62
214
1436
65
235
3.11
14.03
2.8
1.7
1.42
1.69
g/l
0.27
58
215
241
1624
2.24
13.39
16.2
6.7
25.02
27.60
%
3.04
233
1550
239
1607
2.23
13.32
15.4
6.6
60.85
57.30
%
4.61
230
1544
79
329
2.75
13.16
4.2
2.9
73.38
71.53
e9/l
0.09
53
245
264
1867
2.24
12.72
14.0
6.9
10.16
11.59
umol/l
1.94
250
1772
70
280
2.82
12.56
9.8
3.7
130.49
78.79
ng/l
3.54
58
248
84
370
2.61
12.49
10.7
4.0
1.60
1.66
mmol/l
0.05
76
305
78
333
2.67
12.34
4.0
2.4
0.20
0.21
g/l
0.56
72
315
75
316
2.69
12.17
18.5
10.3
—
—
—
0
0
90
416
2.51
12.08
2.6
1.5
—
—
—
0
0
85
387
2.52
11.75
10.3
4.0
7.38
7.38
ph
0.12
67
234
182
1142
2.10
11.61
5.2
3.2
—
—
—
0
0
270
1966
2.17
11.54
19.1
10.1
4.58
4.17
e9/l
1.78
241
1711
246
1735
2.10
11.35
15.3
6.5
0.62
0.58
e9/l
1.99
222
1480
247
1745
2.10
11.35
15.3
6.5
0.04
0.04
e9/l
0.11
223
1491
251
1786
2.11
11.28
15.9
6.7
0.19
0.20
e9/l
0.39
226
1548
70
297
2.65
11.15
6.1
5.1
0.21
0.10
%
0.34
34
87
70
299
2.63
11.00
6.7
4.9
0.89
0.54
%
0.95
36
98
168
1042
2.06
10.88
7.2
3.2
0.52
0.48
e6/l
0.05
135
776
130
737
2.14
10.65
6.7
3.0
494.52
537.13
mosm/kgh2o
1.73
114
639
22
45
5.12
10.38
6.6
3.7
—
—
—
0
0
247
1778
2.03
10.37
15.8
6.5
1.70
1.86
e9/l
2.28
226
1559
244
1751
2.03
10.31
19.7
7.4
1.21
1.21
mmol/l
0.84
209
1505
30
80
3.98
10.24
2.3
1.7
—
—
—
0
0
185
1211
1.99
10.11
7.4
3.4
22.54
109.67
e6/l
0.98
150
942
37
116
3.42
10.00
2.6
4.2
191.06
46.05
mg/l
0.43
28
98
142
852
2.04
9.87
5.9
2.6
5.51
6.27
e6/l
0.25
127
775
70
315
2.48
9.83
6.1
5.0
0.79
0.83
%
0.07
35
107
64
277
2.56
9.74
10.5
4.7
5.06
5.12
kpa
0.23
64
272
63
271
2.58
9.71
10.1
4.8
7.41
7.42
ph
0.19
58
231
34
104
3.48
9.54
2.5
3.9
1.99
2.71
ratio
0.33
18
56
36
116
3.31
9.32
2.7
4.2
50.10
50.97
mg/l
0.02
28
98
227
1629
1.92
9.13
23.7
13.8
1.28
1.25
inr
0.41
198
1360
65
296
2.43
8.86
3.6
3.1
64.45
66.60
g/l
1.23
59
277
82
416
2.22
8.71
7.7
3.2
7.71
8.81
umol/l
0.24
67
370
168
1107
1.90
8.64
4.6
2.6
56.93
55.48
u/l
0.14
156
1031
43
161
2.87
8.64
2.1
2.0
1.62
1.49
g/l
0.41
37
143
26
71
3.85
8.59
2.0
1.5
—
—
—
0
0
195
1363
1.85
8.21
8.7
4.1
101.99
92.74
e6/l
0.08
154
972
266
2050
1.91
8.19
10.7
5.3
6.89
6.66
mmol/l
0.90
255
1929
131
808
1.93
8.14
1.8
1.4
2.34
2.39
g/l
0.12
90
485
168
1125
1.86
8.08
5.4
2.5
—
—
—
0
0
18
39
4.79
7.95
1.1
1.2
—
—
—
0
0
64
306
2.30
7.78
7.5
5.5
0.03
0.18
%
0.70
31
83
203
1454
1.81
7.75
5.2
3.7
6.31
6.25
ph
0.37
112
799
79
413
2.14
7.73
5.9
2.8
4.50
5.10
e9/l
0.40
58
361
221
1633
1.80
7.51
5.6
3.0
207.58
113.68
ug/l
2.38
196
1519
76
396
2.14
7.49
12.0
8.6
0.69
0.89
mmol/l
0.15
63
330
77
404
2.12
7.45
12.5
8.5
7.42
7.42
ph
0.10
45
238
26
79
3.45
7.38
1.5
1.2
—
—
—
0
0
102
595
1.96
7.38
5.6
3.1
1.83
2.35
e6/l
0.45
66
303
77
406
2.11
7.35
11.8
8.4
11.74
11.86
kpa
0.09
71
393
77
406
2.11
7.35
11.9
8.4
4.97
5.08
kpa
0.67
72
392
53
240
2.40
7.28
3.7
2.6
—
—
—
0
0
25
76
3.44
7.09
6.2
2.7
51.56
59.33
%
2.63
25
76
10
6
17.05
6.77
7.1
1.8
—
—
—
0
0
85
479
1.99
6.74
1.2
1.3
—
—
—
0
0
24
74
3.39
6.67
10.5
2.5
—
—
—
0
0
282
2291
1.80
6.47
9.3
4.9
6020.71
3225.02
e6/l
—
7
42
209
1564
1.71
6.41
4.6
2.6
79.84
77.48
nmol/l
0.54
188
1401
94
558
1.90
6.37
5.0
2.8
29.99
29.71
s
0.16
89
545
105
652
1.83
6.16
2.4
2.0
—
—
—
0
0
10
8
12.78
6.11
1.8
1.5
—
—
—
0
0
37
155
2.53
6.00
9.6
6.1
23.78
24.74
mmol/l
1.06
37
148
209
1586
1.67
5.91
18.3
6.9
1.20
1.21
mmol/l
1.55
195
1458
54
270
2.16
5.86
2.0
1.5
—
—
—
0
0
209
1589
1.67
5.85
4.7
2.9
—
—
estimate
—
0
0
11
12
9.39
5.82
3.7
2.3
0.65
0.58
mmol/l
1.25
11
12
43
196
2.34
5.82
9.6
5.4
—
—
—
0
0
65
350
2.03
5.81
5.2
2.4
48.02
31.64
u/l
0.39
55
289
306
2581
1.82
5.80
21.6
8.4
90.75
79.92
u/l
2.04
291
2443
59
307
2.08
5.78
2.2
1.4
—
—
—
0
0
16
31
5.33
5.76
1.3
1.3
—
—
—
0
0
96
594
1.81
5.65
2.0
1.7
979.46
1213.61
nmol/l
1.91
64
449
140
965
1.70
5.65
3.8
2.1
3.21
2.93
mg/l
0.57
124
835
124
828
1.72
5.61
4.7
2.9
374.03
344.27
umol/l
1.85
108
732
152
1073
1.68
5.60
12.6
4.0
7.40
7.40
ph
0.51
121
759
21
68
3.21
5.42
11.6
3.0
15.40
8.59
pmol/l
1.62
21
68
74
427
1.90
5.41
2.3
1.6
—
—
—
0
0
20
63
3.29
5.39
2.2
1.6
156.55
146.89
au/ml
0.13
11
24
156
1120
1.65
5.32
5.9
3.3
30.42
32.98
u/l
0.45
149
1062
60
324
2.00
5.31
3.5
2.2
0.00
0.04
estimate
0.49
11
73
16
35
4.72
5.23
1.2
1.3
—
—
—
0
0
40
190
2.23
4.93
1.4
1.3
—
—
—
0
0
228
1823
1.59
4.83
7.0
4.1
0.00
0.00
estimate
-0.00
55
410
8
7
11.63
4.80
15.4
3.4
—
—
—
0
0
53
284
2.00
4.79
9.9
3.9
1.22
1.22
mmol/l
0.24
48
244
116
794
1.65
4.67
4.4
2.0
1.33
1.37
mg/l
0.07
94
631
198
1542
1.57
4.63
2.7
2.1
87.85
96.53
pmol/l
2.01
105
783
228
1838
1.57
4.55
7.1
4.1
0.00
3.88
estimate
0.50
55
419
277
2337
1.62
4.54
9.5
4.8
—
2.71
—
0
5
88
566
1.71
4.46
2.5
1.6
—
—
—
0
0
15
45
3.43
4.37
3.3
3.1
—
—
—
0
0
53
294
1.93
4.34
2.4
2.3
16.27
7.33
ug/l
0.57
42
258
229
1862
1.55
4.29
7.1
4.2
0.00
0.02
estimate
0.79
55
389
143
1052
1.56
4.20
2.2
1.7
19.85
20.80
nmol/l
0.28
116
874
8
10
8.14
4.08
1.6
1.5
—
—
—
0
0
24
99
2.52
4.05
7.6
3.3
1.21
2.48
index
1.02
14
60
13
31
4.30
4.05
1.1
1.1
—
—
—
0
0
131
953
1.56
4.01
5.0
3.2
0.17
0.12
—
6
26
10
18
5.67
4.00
3.6
2.3
—
—
—
0
0
14
43
3.34
3.94
2.7
1.7
88.49
90.49
%
0.36
14
43
14
44
3.26
3.81
2.0
1.3
—
—
—
0
0
150
1140
1.51
3.70
5.2
3.5
2170.88
1288.07
ng/l
1.25
136
972
53
313
1.80
3.59
9.2
4.1
7.32
7.35
ph
0.24
38
230
27
125
2.24
3.57
1.5
1.4
—
—
—
0
0
14
46
3.12
3.56
1.9
2.3
33.29
32.76
pg
0.19
14
46
12
31
3.96
3.52
3.6
2.6
—
—
—
0
0
60
372
1.72
3.44
3.1
2.0
342.56
379.40
nmol/l
0.69
55
349
17
64
2.73
3.44
2.4
1.8
—
—
—
0
0
24
108
2.30
3.39
1.4
1.4
216.15
287.04
ug/g
0.86
13
63
7
10
7.10
3.37
1.6
2.3
—
—
—
0
0
70
455
1.65
3.37
3.6
2.4
147.37
128.48
ug/g
0.18
54
352
25
117
2.21
3.24
1.6
1.3
—
—
—
0
0
8
15
5.42
3.20
1.1
1.0
—
—
—
0
0
15
55
2.80
3.19
2.1
1.6
—
—
—
0
0
15
55
2.80
3.19
2.1
1.6
—
—
—
0
0
15
55
2.80
3.19
2.1
1.6
—
—
—
0
0
15
55
2.80
3.19
2.1
1.6
—
—
—
0
0
36
196
1.92
3.14
3.2
3.7
4.26
4.57
pmol/l
0.98
29
173
191
1559
1.43
3.13
30.0
12.2
0.00
0.00
e9/l
0.60
163
1272
32
168
1.98
3.10
4.0
2.2
0.00
0.02
estimate
—
7
59
154
1218
1.43
2.96
4.8
3.5
2.34
2.36
mmol/l
0.69
136
1100
106
782
1.49
2.92
9.0
5.2
—
—
—
0
0
29
151
1.99
2.88
3.0
1.9
—
—
—
0
0
162
1300
1.42
2.85
2.8
2.2
—
—
—
0
0
13
47
2.83
2.84
1.2
1.3
—
—
—
0
0
36
205
1.83
2.76
4.2
4.1
—
—
—
0
0
8
19
4.27
2.69
2.3
1.7
42.19
57.03
ug/l
—
8
19
140
1104
1.41
2.69
3.7
2.1
146.00
282.74
u/l
1.37
133
1040
7
15
4.73
2.61
5.4
1.9
1322.57
887.40
u/ml
—
7
15
9
25
3.66
2.59
3.4
1.8
1.33
2.00
u/field
—
9
12
166
1356
1.39
2.57
6.0
4.1
54.94
41.53
ng/l
0.28
136
993
14
56
2.55
2.56
1.1
1.1
—
17.51
—
0
20
39
236
1.72
2.46
4.1
4.3
284.12
229.44
ng/l
0.39
33
217
10
32
3.18
2.45
2.1
1.9
—
—
—
0
0
11
38
2.95
2.43
1.0
1.1
—
—
—
0
0
11
39
2.87
2.36
1.2
1.2
—
—
—
0
0
7
18
3.94
2.26
2.7
2.1
—
—
—
0
0
245
2159
1.35
2.23
6.0
3.4
71.00
47.16
u/l
1.44
228
2044
10
35
2.90
2.22
1.7
1.0
—
—
—
0
0
108
839
1.39
2.21
6.0
3.9
—
0.18
—
0
11
129
1033
1.37
2.19
13.6
6.8
—
—
—
0
0
9
30
3.05
2.16
8.2
2.5
0.33
0.90
index
—
9
30
21
109
1.98
2.14
1.5
1.2
—
—
—
0
0
8
25
3.24
2.10
2.5
3.6
1062.00
805.84
mg
—
8
25
166
1391
1.33
2.07
6.8
4.0
0.13
0.03
estimate
0.50
46
351
6
15
4.04
2.04
4.5
1.3
0.50
1.40
u/field
—
6
10
11
44
2.54
2.03
3.1
1.4
87.25
34.41
ng/l
0.34
11
44
88
671
1.40
1.99
4.9
4.1
129.73
362.35
ng/l
1.41
79
536
57
402
1.49
1.95
1.4
1.4
—
—
—
0
0
5
11
4.59
1.94
2.0
1.8
46.40
25.36
%
—
5
11
125
1014
1.34
1.92
6.4
3.5
0.04
0.01
estimate
0.32
46
331
44
295
1.55
1.90
10.1
3.6
—
—
—
0
0
6
17
3.57
1.84
1.3
1.4
—
—
—
0
0
53
373
1.49
1.84
4.8
4.4
53.64
42.59
ug/l
0.08
46
312
5
12
4.21
1.83
1.0
1.3
—
—
—
0
0
43
291
1.54
1.79
2.8
2.6
6.10
6.15
ph
0.12
29
196
11
48
2.33
1.72
2.4
2.9
1.21
1.19
mmol/l
0.47
11
48
131
1088
1.30
1.68
6.0
4.2
27.30
8.51
mg/mmol
1.66
77
692
11
49
2.28
1.65
2.4
2.8
4.03
4.06
mmol/l
0.08
11
49
11
49
2.28
1.65
2.4
2.8
105.00
105.76
mmol/l
0.28
11
49
13
63
2.10
1.61
1.6
1.4
—
—
—
0
0
60
445
1.41
1.60
1.3
1.3
—
—
—
0
0
5
15
3.36
1.53
1.4
2.2
—
—
—
0
0
17
94
1.84
1.49
8.9
4.5
—
—
—
0
0
22
133
1.69
1.46
3.3
2.6
—
—
—
0
0
61
462
1.38
1.45
1.5
1.4
670.77
566.85
titre
0.10
13
111
5
16
3.15
1.44
3.0
1.5
94.40
67.77
ng/l
—
5
16
6
22
2.75
1.44
1.3
1.3
—
—
—
0
0
7
29
2.44
1.40
2.0
1.5
14.43
16.53
%
—
7
29
7
29
2.44
1.40
1.3
1.1
—
—
—
0
0
136
1160
1.26
1.38
5.1
3.4
6.75
7.67
mmol/l
1.18
104
989
0
37
0.00
1.35
0.0
3.0
—
—
—
0
0
16
90
1.81
1.35
2.7
2.3
11.61
11.94
mg/l
0.07
16
84
10
47
2.16
1.34
1.3
1.3
—
—
—
0
0
9
42
2.17
1.34
1.0
1.0
—
—
—
0
0
125
1061
1.26
1.32
7.5
4.2
0.00
0.01
estimate
0.50
50
381
89
725
1.29
1.30
1.9
1.7
506.00
11148536.31
pmol/l
0.50
71
601
8
34
2.38
1.30
2.5
1.5
—
—
—
0
0
107
897
1.26
1.25
1.3
1.3
0.55
1.84
u/ml
2.18
24
254
5
19
2.65
1.22
1.0
2.0
—
—
—
0
0
21
133
1.61
1.20
5.6
4.2
656.08
215.52
mg/l
0.96
13
65
42
310
1.40
1.18
2.1
1.5
—
—
—
0
0
8
39
2.07
1.16
1.3
1.1
—
—
—
0
0
8
39
2.07
1.16
1.3
1.1
—
—
—
0
0
5
20
2.52
1.15
28.8
6.5
97.40
91.79
mg/l
—
5
14
11
58
1.92
1.13
2.1
1.6
—
—
—
0
0
15
88
1.73
1.13
4.3
2.3
97.56
58.29
ug/min
—
9
47
13
73
1.81
1.12
1.5
1.2
—
—
—
0
0
7
31
2.28
1.11
1.3
1.1
—
—
—
0
0
8
41
1.97
1.09
1.4
1.0
—
—
—
0
0
7
32
2.21
1.08
1.7
2.9
—
—
—
0
0
112
959
1.23
1.08
1.6
1.5
—
—
—
0
0
337
3226
1.30
1.07
53.6
16.8
31.62
23.50
mg/l
4.23
319
2668
123
1070
1.22
1.01
5.0
3.5
118.13
47.68
mg/l
1.45
77
700
74
612
1.26
0.97
1.3
1.3
30.43
32.75
iu/ml
0.11
32
194
32
236
1.39
0.93
1.3
1.2
—
—
—
0
0
6
30
2.01
0.87
1.0
1.2
102.17
99.07
pmol/l
—
6
30
8
45
1.79
0.84
1.1
1.3
—
—
—
0
0
294
3073
0.83
0.84
6.3
5.2
6.05
5.93
mmol/l
0.72
262
2804
85
728
1.21
0.82
3.9
2.9
2.45
2.45
mmol/l
0.03
70
659
6
32
1.89
0.82
1.0
1.2
—
—
—
0
0
6
33
1.83
0.79
1.7
1.5
6.75
8.48
mmol/l
—
6
33
104
1176
0.84
0.77
3.8
3.2
—
—
—
0
0
9
53
1.71
0.76
1.9
1.7
5.03
5.25
mmol/24h
—
9
46
7
38
1.86
0.74
3.1
1.9
—
—
—
0
0
17
241
0.69
0.74
1.3
1.3
—
—
—
0
0
9
57
1.59
0.71
1.8
1.3
—
—
—
0
0
5
26
1.93
0.71
1.4
1.1
—
—
—
0
0
5
28
1.80
0.66
1.6
1.3
—
—
—
0
0
0
23
0.00
0.58
0.0
1.5
—
69.87
—
0
23
6
35
1.73
0.58
2.8
1.4
—
—
—
0
0
6
39
1.55
0.53
5.7
4.1
1.60
3.50
nmol/l
—
6
39
6
39
1.55
0.53
1.8
2.7
12.72
10.94
%
—
6
39
11
75
1.48
0.51
1.3
1.9
—
—
—
0
0
16
118
1.37
0.51
1.0
1.2
—
—
—
0
0
65
573
1.16
0.48
1.3
1.3
7.72
10.74
u/ml
0.24
24
223
21
165
1.29
0.46
1.5
1.4
0.14
0.27
mg/l
—
10
72
11
152
0.72
0.45
1.0
1.1
—
—
—
0
0
5
32
1.57
0.42
1.8
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
3.7
—
—
—
0
0
0
17
0.00
0.40
0.0
3.4
—
—
—
0
0
5
34
1.48
0.40
1.0
1.0
—
—
—
0
0
17
215
0.78
0.40
1.8
1.9
3.57
3.43
mmol/l
0.14
12
160
7
102
0.68
0.40
1.9
1.8
35.43
43.53
nmol/l
—
7
96
10
137
0.72
0.39
2.1
1.7
—
—
—
0
0
0
19
0.00
0.39
0.0
10.7
—
0.64
—
0
19
0
19
0.00
0.39
0.0
1.8
—
198.33
—
0
19
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
5
76
0.65
0.36
1.8
1.4
—
—
—
0
0
219
2275
0.92
0.36
5.7
4.2
—
0.20
—
0
5
6
42
1.44
0.35
16.8
5.1
404.17
354.42
umol/l
—
6
36
6
45
1.34
0.34
1.5
1.9
—
—
—
0
0
20
164
1.23
0.33
1.3
1.3
—
—
—
0
0
17
141
1.21
0.26
1.2
1.6
—
—
—
0
0
17
141
1.21
0.26
1.2
1.6
—
—
—
0
0
17
142
1.21
0.25
1.2
1.6
—
—
—
0
0
88
829
1.08
0.23
5.5
4.3
1.02
1.02
kg/l
0.29
68
549
7
92
0.76
0.22
2.0
1.2
0.88
0.87
g/l
—
7
92
5
43
1.16
0.21
1.0
1.2
—
—
—
0
0
6
48
1.25
0.20
1.2
1.4
—
98.12
—
0
6
13
108
1.21
0.20
1.2
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
0.00
—
0
14
39
357
1.10
0.19
1.7
1.8
—
—
—
0
0
7
58
1.21
0.18
1.1
1.0
—
—
—
0
0
7
63
1.11
0.17
10.7
5.9
11.00
11.05
mmol/l
—
7
56
7
63
1.11
0.17
10.7
5.9
106.86
105.09
mmol/l
—
7
56
31
338
0.91
0.16
1.8
1.7
—
—
—
0
0
6
77
0.78
0.15
2.2
1.5
—
—
—
0
0
16
140
1.15
0.15
1.1
1.6
—
—
—
0
0
328
3313
0.94
0.14
38.2
14.7
—
—
—
0
0
36
334
1.09
0.14
2.0
1.6
—
—
—
0
0
12
103
1.17
0.14
1.3
1.9
—
—
—
0
0
19
171
1.12
0.12
2.4
2.4
—
—
—
0
0
261
2575
1.04
0.12
4.6
4.4
14.56
14.89
pmol/l
1.36
232
2325
33
308
1.08
0.11
1.2
1.2
—
—
—
0
0
303
3060
0.96
0.11
5.7
5.1
1.40
1.48
mmol/l
2.23
273
2821
56
586
0.95
0.11
3.4
3.4
1.24
0.76
ug/l
0.33
36
393
95
978
0.96
0.10
5.4
5.9
13.20
2.59
ug/l
0.58
82
872
20
184
1.09
0.09
1.2
1.1
—
—
—
0
0
7
67
1.05
0.08
2.1
3.6
35.29
27.46
u/ml
—
7
67
8
91
0.88
0.07
1.0
1.0
—
—
—
0
0
8
95
0.84
0.06
1.5
1.4
—
—
—
0
0
9
103
0.87
0.06
18.8
11.4
—
—
—
0
0
134
1320
1.02
0.05
2.2
1.9
1.32
1.30
mmol/l
0.14
110
1099
19
179
1.06
0.05
1.8
3.0
87.95
35.54
u/ml
0.72
19
173
18
191
0.94
0.04
1.1
1.1
—
38.50
—
0
6
306
3075
0.98
0.04
5.6
5.2
4.46
4.56
mmol/l
0.93
275
2849
311
3124
0.98
0.04
6.1
5.9
2.56
2.64
mmol/l
0.78
281
2886
293
2919
1.01
0.02
5.0
4.3
1.38
1.25
mmol/l
2.02
259
2672
23
238
0.96
0.02
1.4
1.3
23.18
135.38
u/ml
—
8
93
14
133
1.05
0.01
1.2
1.6
—
—
—
0
0
15
143
1.05
0.01
2.5
1.6
20.45
22.58
iu/l
—
10
120
336
3368
0.98
0.01
27.2
12.3
24.99
24.96
u/l
0.01
327
3269
297
2963
1.01
0.01
9.0
6.6
41.14
39.36
mmol/mol
1.80
274
2772
303
3031
1.00
0.00
6.0
5.4
1.83
1.91
mu/l
0.63
272
2777
0
7
0.00
0.00
0.0
1.0
—
3.46
—
0
7
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
9
97
0.93
0.00
1.4
2.0
—
—
—
0
0
5
52
0.96
0.00
1.8
1.8
17.83
17.08
ug/l
—
5
52
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
48.42
—
0
8
0
6
0.00
-0.00
0.0
3.5
—
49.00
—
0
6
0
5
0.00
-0.00
0.0
1.8
—
0.52
—
0
5
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
18.60
—
0
5
0
6
0.00
-0.00
0.0
1.8
—
58.33
—
0
6
0
5
0.00
-0.00
0.0
2.6
—
3721.00
—
0
5
7
70
1.00
-0.00
1.0
1.1
—
—
—
0
0
8
87
0.92
-0.00
1.4
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
53.33
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
60
1.00
-0.00
1.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint AB1_OTHER_BACT_INOTHER and mortality.

Females

Parameter HR [95% CI] p-value
AB1_OTHER_BACT_INOTHER 2.026 [1.66, 2.48] < 0.001
Birth year 0.995 [0.99, 1.0] 0.22

During the follow-up period (1.1.1998 — 31.12.2019), 562 out of 1325 females with AB1_OTHER_BACT_INOTHER died.

Males

Parameter HR [95% CI] p-value
AB1_OTHER_BACT_INOTHER 2.755 [2.11, 3.59] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 352 out of 852 males with AB1_OTHER_BACT_INOTHER died.

Mortality risk

Mortality risk for people of age

years, who have AB1_OTHER_BACT_INOTHER.

N-year risk Females Males
1 0.208% 0.509%
5 1.246% 2.961%
10 3.141% 7.155%
15 5.804% 13.554%
20 10.293% 21.955%

Relationships between endpoints

Index endpoint: AB1_OTHER_BACT_INOTHER – Other bacterial agents as the cause of diseases classified to other chapters

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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