Plasmodium falciparum malaria, including avohilmo

AB1_MALARIA_FALCIPARIUM_WIDE

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Primary healthcare outpatient: ICD-10 B50
  • Hospital discharge: ICD-10 B50
  • Hospital discharge: ICD-9 084[0]
  • Hospital discharge: ICD-8 084[0]
  • Cause of death: ICD-10 B50
  • Cause of death: ICD-9 084[0]
  • Cause of death: ICD-8 084[0]

3 out of 7 registries used, show all original rules.

100

4. Check minimum number of events

None

100

5. Include endpoints

None

100

6. Filter based on genotype QC (FinnGen only)

83

Control definitions (FinnGen only)

Control exclude
AB1_PROTOZOAL

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 83 49 34
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 37.95 34.81 42.48

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
93
Matched controls
930
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
B50.9
ICD-10 Finland
Plasmodium falciparum malaria, unspecified
+∞
69.8
58
*
0840A
ICD-9 Finland
Malaria, Falciparum malaria [malignant tertian]
+∞
17.2
16
*
08400
ICD-8 Finland
Falicparum malaria (malignant tertian)
+∞
8.5
8
*
B50.0
ICD-10 Finland
Plasmodium falciparum malaria with cerebral complications
+∞
8.5
8
*
B54
ICD-10 Finland
Unspecified malaria
+∞
7.4
7
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
46
306
2.00
2.70
3.5
3.5
18.95
47.26
e6/l
1.03
33
213
29
176
1.94
2.13
2.3
2.0
—
—
—
0
0
13
61
2.31
1.81
1.9
1.8
—
—
—
0
0
18
99
2.01
1.72
2.2
1.7
—
—
—
0
0
48
359
1.70
1.71
10.3
11.8
0.00
0.01
e9/l
0.53
37
285
37
258
1.72
1.70
6.8
5.7
—
—
—
0
0
54
422
1.67
1.59
7.3
6.6
0.04
0.04
e9/l
0.14
42
360
50
384
1.65
1.57
7.2
6.3
0.64
0.68
%
0.19
45
355
54
423
1.66
1.57
7.3
6.7
2.19
1.86
e9/l
0.52
43
376
50
386
1.64
1.52
7.2
6.2
2.07
2.92
%
2.25
45
360
50
387
1.63
1.50
7.2
6.2
8.98
8.44
%
0.70
45
363
13
67
2.09
1.47
1.0
1.2
—
—
—
0
0
50
390
1.61
1.43
7.3
6.2
30.12
27.82
%
0.55
45
370
55
440
1.61
1.41
8.1
6.9
0.15
0.21
e9/l
2.25
44
387
32
224
1.65
1.41
2.4
3.1
—
0.00
—
0
6
53
422
1.60
1.38
7.4
6.6
0.55
0.58
e9/l
0.38
41
364
5
17
3.05
1.37
2.0
1.6
—
—
—
0
0
58
473
1.60
1.35
10.7
10.6
3.81
4.10
e9/l
0.50
47
412
17
100
1.86
1.35
1.9
1.8
—
—
—
0
0
37
274
1.58
1.29
2.9
2.8
14.92
39.08
e6/l
1.30
29
209
6
25
2.49
1.26
3.7
2.2
—
—
—
0
0
0
36
0.00
1.17
0.0
1.2
—
—
—
0
0
33
243
1.55
1.16
7.2
6.1
—
—
—
0
0
77
689
1.68
1.07
18.8
17.7
13.75
13.52
%
0.87
77
681
10
54
1.95
1.01
1.3
1.4
24.01
22.29
iu/l
—
10
44
16
102
1.69
0.98
1.4
1.7
—
—
—
0
0
15
95
1.69
0.94
1.8
1.7
—
—
—
0
0
15
99
1.61
0.82
3.7
2.8
123.50
98.81
ug/g
—
10
82
21
151
1.50
0.80
1.7
1.6
—
—
—
0
0
29
226
1.41
0.74
3.0
2.7
—
—
estimate
—
0
0
40
330
1.37
0.73
2.0
2.0
91.77
98.67
pmol/l
0.52
24
171
30
237
1.39
0.71
3.0
2.8
0.33
0.26
e6/l
0.13
24
173
20
147
1.46
0.69
2.8
2.8
45.79
249.84
ng/l
0.52
14
107
5
29
1.76
0.65
1.4
1.5
—
—
—
0
0
5
29
1.76
0.65
1.4
1.4
1.52
1.18
mm
—
5
21
5
29
1.76
0.65
1.4
1.4
—
—
—
0
0
12
80
1.57
0.63
1.6
1.4
—
—
—
0
0
29
232
1.36
0.63
1.7
1.6
—
—
—
0
0
15
106
1.49
0.62
1.3
1.3
—
—
—
0
0
0
21
0.00
0.61
0.0
1.4
—
—
—
0
0
26
206
1.36
0.60
2.6
2.0
2.65
2.76
mg/l
0.05
20
182
8
125
0.61
0.59
1.6
1.4
—
—
—
0
0
6
37
1.66
0.57
1.5
1.2
—
—
—
0
0
14
101
1.45
0.53
1.5
1.2
—
—
—
0
0
79
745
1.40
0.49
5.8
5.4
1.71
1.86
mu/l
0.55
72
693
67
619
1.29
0.47
8.8
8.3
74.07
75.90
u/l
0.19
60
584
7
49
1.46
0.47
1.3
1.2
—
—
—
0
0
6
92
0.63
0.45
1.2
1.3
—
—
—
0
0
39
340
1.25
0.44
2.3
1.9
1.27
1.37
mmol/l
0.35
31
283
0
16
0.00
0.41
0.0
1.9
—
—
—
0
0
5
34
1.50
0.41
1.0
3.8
—
—
—
0
0
5
34
1.50
0.41
1.4
1.9
—
—
—
0
0
36
318
1.22
0.35
2.5
2.0
—
—
—
0
0
42
377
1.21
0.35
4.0
7.2
1.23
1.21
mmol/l
1.21
36
331
66
620
1.22
0.33
5.1
4.6
14.09
14.74
pmol/l
1.60
58
578
46
419
1.19
0.32
3.0
3.9
0.00
0.00
estimate
—
8
94
26
224
1.22
0.32
4.1
4.4
—
—
—
0
0
7
54
1.32
0.31
2.0
2.8
—
—
—
0
0
46
420
1.19
0.31
3.0
4.0
0.00
0.00
estimate
—
8
91
28
244
1.21
0.31
2.2
3.2
0.00
0.00
estimate
—
7
75
25
219
1.19
0.26
2.3
2.4
—
—
—
0
0
78
752
1.23
0.24
4.2
4.0
1.22
1.29
mmol/l
0.40
73
696
86
838
1.35
0.24
19.5
18.5
76.64
76.43
umol/l
0.03
86
829
22
249
0.85
0.22
4.0
3.3
—
—
—
0
0
5
42
1.20
0.22
1.2
5.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
79.30
—
0
10
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
0.16
—
0
7
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
3.4
—
2.62
—
0
13
6
52
1.16
0.19
1.7
1.2
—
—
—
0
0
36
332
1.14
0.19
2.8
3.4
6.13
6.18
ph
0.08
19
184
74
763
0.85
0.18
5.7
4.6
6.14
5.89
mmol/l
0.47
68
707
46
432
1.13
0.18
3.1
4.0
0.00
0.00
estimate
—
7
85
22
245
0.87
0.18
2.9
3.9
0.00
0.01
estimate
—
8
82
7
62
1.14
0.18
2.1
3.8
71.86
82.73
ng/l
—
7
55
81
829
0.82
0.17
12.5
12.6
—
—
—
0
0
36
386
0.89
0.17
3.1
2.8
—
—
estimate
—
0
0
10
119
0.82
0.16
2.5
2.1
—
—
—
0
0
30
322
0.90
0.14
2.8
3.9
0.00
0.00
estimate
—
6
80
34
362
0.90
0.13
4.6
3.0
—
—
—
0
0
80
785
1.14
0.10
5.2
4.7
1.49
1.46
mmol/l
0.23
74
730
5
44
1.14
0.10
1.0
1.1
—
—
—
0
0
5
46
1.09
0.10
1.6
5.7
24.30
25.33
mmol/l
—
5
46
6
55
1.10
0.09
1.0
2.7
2.45
5.90
ug/l
—
6
49
5
61
0.81
0.08
1.2
1.3
—
—
—
0
0
88
869
1.24
0.08
23.9
22.7
134.55
136.26
g/l
0.55
88
859
88
868
1.26
0.08
23.8
22.8
40.55
40.71
%
0.14
88
858
88
868
1.26
0.08
23.8
22.6
4.51
4.52
e12/l
0.06
88
853
88
868
1.26
0.08
23.7
22.5
30.12
30.33
pg
0.43
88
860
88
868
1.26
0.08
23.8
22.6
6.74
6.77
e9/l
0.04
88
854
88
867
1.28
0.08
23.7
22.6
90.24
90.96
fl
0.60
88
859
88
867
1.28
0.08
23.9
22.6
247.36
253.75
e9/l
0.54
88
853
7
67
1.05
0.08
3.3
3.6
—
—
—
0
0
12
108
1.13
0.07
1.5
3.4
4.04
6.46
e9/l
0.56
12
95
82
808
1.13
0.07
15.8
16.2
139.73
139.73
mmol/l
0.00
82
794
26
246
1.08
0.07
3.1
3.8
7.40
7.39
ph
0.62
14
177
18
193
0.92
0.07
5.8
6.2
—
—
—
0
0
36
346
1.07
0.06
18.1
10.5
1.43
1.18
inr
1.29
28
288
10
111
0.89
0.06
5.0
6.6
103.70
103.98
mmol/l
—
10
111
18
168
1.09
0.06
1.8
1.4
1.85
2.25
g/l
—
9
106
24
228
1.07
0.05
4.8
3.3
12.69
58.07
mg/l
2.83
19
153
29
302
0.94
0.05
3.4
3.7
93.35
39.15
ng/l
0.32
17
202
25
241
1.05
0.03
4.8
3.2
7.84
8.17
mmol/l
0.12
20
203
27
277
0.96
0.01
2.6
2.2
—
—
—
0
0
23
234
0.98
0.00
6.3
3.9
2.41
11.39
mg/mmol
2.17
15
152
80
801
0.99
0.00
14.9
15.0
22.42
22.88
mg/l
0.04
62
651
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
130.20
—
0
5
0
5
0.00
0.00
0.0
2.2
—
16.64
—
0
5
0
5
0.00
0.00
0.0
1.0
—
76.80
—
0
5
0
5
0.00
0.00
0.0
1.4
—
95.00
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
90.08
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
121.98
—
0
6
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
7
75
0.93
-0.00
1.3
3.4
1.31
1.68
mmol/l
—
7
62
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
7.5
—
—
—
0
0
6
62
0.97
-0.00
1.7
7.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
263.33
—
0
6
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
9
95
0.94
-0.00
1.6
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
5.7
—
0.60
—
0
6
0
7
0.00
-0.00
0.0
2.0
—
9.16
—
0
7
11
110
1.00
-0.00
1.5
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
6.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
10.00
—
0
8

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: AB1_MALARIA_FALCIPARIUM_WIDE – Plasmodium falciparum malaria, including avohilmo

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).