This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Type 1 diabetes, wide definition, subgroup 2
T1D_WIDE2
type I diabetes mellitus: A chronic condition characterized by minimal or absent production of insulin by the pancreas.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditions
|
1366 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
813 |
6. Filter based on genotype QC (FinnGen only) |
656 |
Control definitions (FinnGen only)
- Control exclude
- DIABETES_FG
- Control conditions
- not PANCREATITIS
and not INSULIN_INTER_AND_LONG
and not KELA_DIAB_INSUL
and not INSULIN_SHORTFAST
Extra metadata
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Type 1 diabetes, wide definition, subgroup 2
based on the number of shared cases.
Similar with more cases:
- Type 1 diabetes, wide definition
- Sub-endpoint used in defining T1D endpoints
- Insulin, fast-acting or short human
- Insulin, combination of fast acting with intermediate-acting or long-acting
- Insulin medication
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8193 | 3476 | 4409 |
| Only index persons | 2249 | 991 | 1258 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.10 | 0.12 |
| Only index persons | 0.04 | 0.04 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 53.87 | 58.28 | 50.15 |
| Only index persons | 48.96 | 53.50 | 45.38 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 656 | 287 | 369 |
| Unadjusted period prevalence (%) | 0.14 | 0.10 | 0.17 |
| Median age at first event (years) | 56.58 | 57.46 | 55.89 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 679
- Matched controls
- 6790
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A10AA02, ,
ATC
+∞
307.7
476
*
A10BA02
ATC
metformin; oral
93.2
307.7
253
43
103
Kela drug reimbursment
Diabetes, insulin-treated
+∞
307.7
679
*
A10AA01, ,
ATC
+∞
307.7
343
*
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
288.3
307.7
397
33
2500A
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE,TYYPPI II]
+∞
307.7
320
*
A10AC01
ATC
insulin (human); parenteral
4495.3
307.7
613
14
A10AB01
ATC
insulin (human); parenteral
16384.0
307.7
528
*
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
+∞
307.4
271
*
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
+∞
282.7
251
*
A10AB05
ATC
insulin aspart; parenteral
572.2
269.7
251
7
A10AD01
ATC
insulin (human); parenteral
+∞
259.5
232
*
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
3174.8
256.0
231
*
A10BB01
ATC
glibenclamide; oral
814.5
239.6
222
*
A10AB04
ATC
insulin lispro; parenteral
2920.4
213.2
195
*
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
96.4
189.4
99
12
215
Kela drug reimbursment
Diabetes, non-insulin-treated
+∞
182.8
167
*
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
+∞
179.3
164
*
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
+∞
164.4
151
*
A10BX01
ATC
guar gum; oral
24.3
156.3
116
57
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
+∞
129.4
120
*
H04AA01
ATC
glucagon; nasal, parenteral
+∞
120.5
112
*
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
+∞
118.3
110
*
A10AD05
ATC
insulin aspart; parenteral
+∞
114.9
107
*
A10AA03, ,
ATC
+∞
111.6
104
*
E11.2
ICD-10 Finland
Type 2 diabetes mellitus, with renal complications
1114.2
100.8
96
*
A98
ICPC
Health maint/preventive medicine
0.2
99.3
168
4495
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
17.2
94.6
81
53
CKC10
NOMESCO Finland
Local photocoagulation of retina
21.0
90.4
70
37
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
5.8
86.7
198
450
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
+∞
86.3
81
*
T89
ICPC
Diabetes insulin dependent
242.4
84.5
85
*
NHQ40
NOMESCO Finland
Amputation of toe
19.5
83.7
67
38
4019X
ICD-9 Finland
Essential hypertension, Unspecified
8.7
81.7
113
152
T90
ICPC
Diabetes non-insulin dependent
11.1
80.1
90
92
C02EA02, ,
ATC
7.7
79.8
125
194
C09AA02
ATC
enalapril; systemic
4.6
79.8
284
923
A12AA04
ATC
calcium carbonate; oral
21.1
78.1
60
31
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
14.8
77.8
72
54
XCK10
NOMESCO Finland
Photography of fundus of eye
7.4
77.8
127
206
A10AE04
ATC
insulin glargine; parenteral
416.9
76.4
75
*
A10BB12
ATC
glimepiride; oral
170.8
73.6
76
5
201
Kela drug reimbursment
Chronic cardiac insufficiency
5.9
69.8
146
302
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
739.9
69.3
67
*
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
715.4
67.2
65
*
C09AA01
ATC
captopril; oral
11.4
65.2
71
69
H36.00
ICD-10 Finland
Diabetic background retinopathy
+∞
64.6
61
*
H3601, E113,
ICD-10 Finland
+∞
63.5
60
*
A11CC03
ATC
alfacalcidol; systemic
12.3
62.2
64
57
205
Kela drug reimbursment
Chronic hypertension
3.7
61.6
341
1458
2507A
ICD-9 Finland
Diabetes mellitus, Diabetes with peripheral circulatory disorders[DIABETES MELLITUS CUM COMPLICAT ALIA ,TYYPPI II]
+∞
59.2
56
*
H3603, E113,
ICD-10 Finland
+∞
59.2
56
*
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
606.9
57.5
56
*
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
+∞
57.1
54
*
E11.4
ICD-10 Finland
Type 2 diabetes mellitus, with neurological complications
+∞
56.0
53
*
E10
ICD-10 Finland
Type 1 diabetes mellitus
+∞
53.9
51
*
A10AE05
ATC
insulin detemir; parenteral
199.1
53.8
55
*
H3600, E113,
ICD-10 Finland
+∞
52.8
50
*
H36.01
ICD-10 Finland
Diabetic maculopathy
+∞
52.8
50
*
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
548.0
52.2
51
*
B03XA01
ATC
erythropoietin; parenteral
15.3
51.5
46
32
C03CA01
ATC
furosemide; systemic
3.2
47.2
406
2166
N02BE01
ATC
paracetamol; systemic, rectal
0.3
47.2
268
4582
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
+∞
46.4
44
*
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
+∞
46.4
44
*
4148X
ICD-9 Finland
Other forms of chronic ischaemic heart disease, Other specified forms of chronic ischaemic heart disease[MORBUS CORDIS ISCHAEMICUS ALIA,MÄÄRITTELEMÄT]
12.2
46.0
47
41
E14.9
ICD-10 Finland
Unspecified diabetes mellitus, without complications
478.4
45.8
45
*
A10BB07
ATC
glipizide; oral
164.2
44.4
46
*
I50.1
ICD-10 Finland
Left ventricular failure
5.2
44.3
100
218
H43.1
ICD-10 Finland
Vitreous haemorrhage
11.7
43.7
46
42
2505A
ICD-9 Finland
Diabetes mellitus, Diabetes with ophthalmic manifestations[NEUROPATHIA DIABETICA,TYYPPI II]
+∞
43.2
41
*
81
HP
Angiography of the heart and coronary arteries
4.6
43.1
116
292
C10AB02
ATC
bezafibrate; oral
14.7
42.8
39
28
2500X
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,NUD]
+∞
42.1
40
*
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
+∞
42.1
40
*
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
+∞
40.0
38
*
H3600, E103,
ICD-10 Finland
+∞
40.0
38
*
NGQ20
NOMESCO Finland
Amputation of lower leg
54.7
39.1
46
9
CKC15
NOMESCO Finland
Panretinal photocoagulation
54.7
39.1
46
9
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
+∞
38.9
37
*
4402A
ICD-9 Finland
Atherosclerosis, Of native arteries of the extremities
8.8
38.5
50
61
2507B
ICD-9 Finland
Diabetes mellitus, Diabetes with peripheral circulatory disorders[DIABETES MELLITUS CUM COMPLICAT ALIA ,TYYPPI I]
+∞
37.9
36
*
E11.6
ICD-10 Finland
Type 2 diabetes mellitus, with other specified complications
387.6
37.4
37
*
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
6.9
36.8
59
92
H3603, E103,
ICD-10 Finland
+∞
36.8
35
*
B01AC06
ATC
acetylsalicylic acid; oral
4.6
36.5
96
236
E11
ICD-10 Finland
Type 2 diabetes mellitus
9.5
36.3
44
49
C01DA14
ATC
isosorbide mononitrate; oral
2.8
34.9
249
1154
TK800
NOMESCO Finland
Hemodialysis
11.5
34.9
37
34
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
2.7
34.4
304
1570
NFQ20
NOMESCO Finland
Amputation of femur
13.9
34.2
32
24
A12BA01
ATC
potassium chloride; oral
3.9
33.6
110
318
25002
ICD-8 Finland
Diabetes mellitus, Retinopathia diabetica
+∞
33.6
32
*
J01DA01
ATC
[U] cefalexin
2.8
33.0
471
3052
V03AE01
ATC
polystyrene sulfonate; oral
10.5
33.0
37
37
H36.09*E11.3
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic retinopathy
+∞
32.6
31
*
J01FF01
ATC
clindamycin; systemic
2.8
31.6
204
891
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
+∞
31.5
30
*
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
2.7
31.1
247
1198
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
167.6
30.9
32
*
WX110
NOMESCO Finland
Infiltration anesthesia
0.3
30.9
125
2818
C01AA05
ATC
digoxin; systemic
3.0
30.3
166
661
Z13.1
ICD-10 Finland
Special screening examination for diabetes mellitus
71.4
30.2
34
5
B01AC07
ATC
dipyridamole; systemic
3.5
29.9
116
375
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
52.6
29.6
35
7
C02EA01, ,
ATC
9.9
29.1
34
36
40199
ICD-8 Finland
Essential benign hypertension
5.9
28.9
54
98
SAA01
NOMESCO Finland
Simple examination of mouth
0.3
28.8
115
2644
4120X
ICD-9 Finland
Old myocardial infarction[STATUS POST INFARCTUM CORDIS,MÄÄRITTELEMÄT]
6.3
28.6
50
85
M01AH05
ATC
etoricoxib; oral
0.3
28.6
76
2176
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
+∞
28.3
27
*
I50.0
ICD-10 Finland
Congestive heart failure
3.1
28.0
134
492
11
HP
Coronary artery bypass surgery
6.0
27.8
51
91
C02DE04, ,
ATC
4.6
27.6
69
162
I25.1
ICD-10 Finland
Atherosclerotic heart disease
2.5
27.2
262
1375
NHQ30
NOMESCO Finland
Amputation of foot, transmetatarsal
64.8
27.2
31
5
137
Kela drug reimbursment
Uraemia requiring dialysis
26.0
26.8
37
15
C08DB01
ATC
diltiazem; oral
3.5
26.5
100
317
25008
ICD-8 Finland
Diabetes mellitus, Complicatio alia definita
+∞
26.2
25
*
I79.2*E11.5
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic peripheral angiopathy
+∞
26.2
25
*
4130B
ICD-9 Finland
Angina pectoris, Angina decubitus[ANGINA PECTORIS (""""EFFORT ANGINA""""),AHTAUTUNUT]
6.0
25.9
47
83
40299
ICD-8 Finland
Hypertensive heart disease
10.4
25.8
29
29
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
2.8
25.8
165
709
CL2S4
NOMESCO Finland
Ocular fundus photography for diabetic retinopathy screening
52.2
25.4
30
6
E11.1
ICD-10 Finland
Type 2 diabetes mellitus, with ketoacidosis
+∞
25.2
24
*
SAA02
NOMESCO Finland
Basic examination of mouth
0.3
25.1
98
2332
P20
ICPC
Memory disturbance
0.1
25.1
8
822
4130X
ICD-9 Finland
Angina pectoris, Angina decubitus[ANGINA PECTORIS (""""EFFORT ANGINA""""),MÄÄRITTELEMÄT]
5.2
24.8
53
109
N083, E112,
ICD-10 Finland
+∞
24.1
23
*
2501B
ICD-9 Finland
Diabetes mellitus, Diabetes with ketoacidosis[DIABETES MELLITUS CUM KETOACIDOSI ,TYYPPI I]
+∞
24.1
23
*
I25.2
ICD-10 Finland
Old myocardial infarction
3.1
24.1
115
420
SPAT1053
SPAT
Memory test
0.1
23.8
8
791
5315
FHL
Bypass surgery using a mammary artery
6.9
23.6
37
56
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
20.3
22.3
33
17
D01AC02
ATC
miconazole; topical
3.4
22.2
89
292
B05DA
ATC
Isotonic solutions
30.2
22.0
29
10
2504A
ICD-9 Finland
Diabetes mellitus, Diabetes with renal manifestations[DIABETES MELLITUS CUM COMPLICATIONE OCULI ,TYP II]
+∞
22.0
21
*
B05DB
ATC
Hypertonic solutions
44.9
21.5
26
6
4289X
ICD-9 Finland
Heart failure, unspecified
8.7
21.1
27
32
2506A
ICD-9 Finland
Diabetes mellitus, Diabetes with neurological manifestations[MICROANGIOPATHIA DIABETICA,TYYPPI II]
+∞
20.9
20
*
A10AD04
ATC
insulin lispro; parenteral
+∞
20.9
20
*
A10BH01
ATC
sitagliptin; oral
216.4
20.7
21
*
I70.9
ICD-10 Finland
Generalized and unspecified atherosclerosis
5.2
20.7
44
90
R73.9
ICD-10 Finland
Hyperglycaemia, unspecified
8.5
20.6
27
33
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
19.0
20.6
31
17
K85
ICPC
Elevated blood pressure
0.1
20.5
6
662
J01DA09
ATC
[U] cefadroxil
2.3
20.1
189
961
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
3.1
20.1
91
321
J01MA01
ATC
ofloxacin; systemic
2.9
20.0
102
385
A10AC30
ATC
insulins and analogues for injection, intermediate-acting - combinations; parenteral
+∞
19.9
19
*
2504B
ICD-9 Finland
Diabetes mellitus, Diabetes with renal manifestations[DIABETES MELLITUS CUM COMPLICATIONE OCULI ,TYYPPI I]
+∞
19.9
19
*
H3601, E103,
ICD-10 Finland
+∞
19.9
19
*
C03EB01
ATC
furosemide and potassium-sparing agents; systemic
3.2
19.9
88
306
Z95.1
ICD-10 Finland
Presence of aortocoronary bypass graft
4.0
19.4
58
156
G04AA01, ,
ATC
6.9
19.3
30
45
42700
ICD-8 Finland
Symptomatic heart disease, Congestive heart failure
18.9
19.2
29
16
Z49.1
ICD-10 Finland
Extracorporeal dialysis
15.4
19.1
31
21
I21.9
ICD-10 Finland
Acute myocardial infarction, unspecified
4.1
19.0
55
144
N083, E102,
ICD-10 Finland
+∞
18.8
18
*
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
+∞
18.8
18
*
4100X
ICD-9 Finland
Acute myocardial infarction, Of anterolateral wall[INFARCTUS MYOCARDII ACUTUS DEFINITUS,MÄÄRITTELEMÄT]
4.2
18.8
52
132
S18
ICPC
Laceration/cut
0.3
18.7
75
1830
G63.2*E11.4
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic polyneuropathy
195.2
18.6
19
*
SFA20
NOMESCO Finland
Two-surface restoration
0.3
18.6
80
1888
I25.5
ICD-10 Finland
Ischaemic cardiomyopathy
5.6
18.2
35
65
N18.8
ICD-10 Finland
Other chronic renal failure
5.2
18.0
38
77
SPAT1262
SPAT
Handing over of treatment supplies
2.9
17.9
93
354
SFA10
NOMESCO Finland
One-surface restoration
0.4
17.9
81
1872
3620B
ICD-9 Finland
Other retinal disorders, Diabetic retinopathy[RETINOPATHIA DIABETICA PROLIFERATIVA]
+∞
17.8
17
*
H36.09
ICD-10 Finland
Diabetic retinopathy (E10-E14+ with common fourth character .3)
184.6
17.6
18
*
E13.9
ICD-10 Finland
Other specified diabetes mellitus, without complications
+∞
16.7
16
*
2503B
ICD-9 Finland
Diabetes mellitus, Diabetes with other coma[SOKERITAUDIN AIHEUTTAMA MUNUAISSAIRAUS,TYYPPI I]
+∞
16.7
16
*
XCK20, ,
NOMESCO Finland
+∞
16.7
16
*
J01DB01
ATC
cefalexin; oral
0.5
16.7
281
3965
C09BA02
ATC
enalapril and diuretics; systemic
3.1
16.6
75
263
N06AA09
ATC
amitriptyline; systemic
3.0
16.5
80
292
C07AG02
ATC
carvedilol; oral
3.3
16.5
65
210
E87.5
ICD-10 Finland
Hyperkalaemia
6.5
16.4
27
43
D03BA52
ATC
collagenase, combinations; topical
12.1
16.2
29
25
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
0.4
16.1
81
1804
AA1AD
NOMESCO Finland
CT of head and brain
0.3
16.1
52
1433
GD1AA
NOMESCO Finland
Thorax X-ray examination
0.4
16.0
111
2158
SPAT1256
SPAT
Intramuscular and subcutaneous injection
0.3
15.8
63
1565
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
+∞
15.7
15
*
2506B
ICD-9 Finland
Diabetes mellitus, Diabetes with neurological manifestations[MICROANGIOPATHIA DIABETICA,TYYPPI I]
+∞
15.7
15
*
25009
ICD-8 Finland
Diabetes mellitus, Unspecified
+∞
15.7
15
*
G63.2*E10.4
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic polyneuropathy
+∞
15.7
15
*
Z02.4
ICD-10 Finland
Examination for driving licence
0.2
15.7
27
1070
M04AA01
ATC
allopurinol; systemic
2.3
15.6
131
628
J01CF02
ATC
cloxacillin; systemic
5.6
15.5
30
56
N17
ICPC
Vertigo/dizziness
0.1
15.5
6
542
SPAT1263
SPAT
Sampling
0.4
15.5
72
1670
K86
ICPC
Hypertension uncomplicated
0.1
15.5
*
467
4120B
ICD-9 Finland
Old myocardial infarction[STATUS POST INFARCTUM CORDIS,AHTAUTUNUT]
5.2
15.4
32
64
OAB50, ,
SPAT
4.7
15.3
36
80
C09AA03
ATC
lisinopril; oral
3.7
15.3
50
143
27799
ICD-8 Finland
Obesity not specified as of endocrine origin
29.4
15.3
20
7
C03DA01
ATC
spironolactone; oral
2.4
15.1
112
507
M79.6
ICD-10 Finland
Pain in limb
0.4
15.1
70
1628
B03XA02
ATC
darbepoetin alfa; parenteral
5.6
15.1
29
54
5314
FHL
Bypass surgery for four or more vessels
5.7
14.9
28
51
N18.0
ICD-10 Finland
End-stage renal disease
11.7
14.9
27
24
C07AB08
ATC
celiprolol; oral
4.3
14.8
39
95
J01DA06
ATC
[U] cefuroxime
2.5
14.8
104
460
I79.2*E10.5
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic peripheral angiopathy
+∞
14.6
14
*
2505B
ICD-9 Finland
Diabetes mellitus, Diabetes with ophthalmic manifestations[NEUROPATHIA DIABETICA,TYYPPI I]
+∞
14.6
14
*
H28.0*E11.3
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic cataract
+∞
14.6
14
*
B06AA55
ATC
streptokinase, combinations; systemic, topical
36.9
14.5
18
5
SPAT1153
SPAT
Removal of sutures
0.3
14.5
36
1154
N02AJ06
ATC
codeine and paracetamol; systemic
0.3
14.5
52
1371
K02.1
ICD-10 Finland
Caries of dentine
0.4
14.3
101
1974
213
Kela drug reimbursment
Fat metabolism disorder associated with chronic coronary artery disease
2.5
14.2
95
409
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
0.3
14.2
45
1267
A28
ICPC
Limited function/disability NOS
0.3
14.0
31
1065
G04AC01, ,
ATC
3.6
14.0
48
142
SPAT1325
SPAT
Vaccination
0.4
13.9
65
1518
C08CA02
ATC
felodipine; oral
2.5
13.9
97
427
Z49.2
ICD-10 Finland
Other dialysis
24.4
13.8
19
8
XFP96
NOMESCO Finland
Other intraoperative electrophysiological investigation in arhythmia or disturbance of impulse propagation
4.3
13.8
36
87
SPAT1301
SPAT
No procedures
0.3
13.7
48
1288
KMAK, ,
NOMESCO Finland
0.4
13.7
79
1684
G04AB05, ,
ATC
4.2
13.7
37
92
J01MA02
ATC
ciprofloxacin; systemic
1.9
13.6
279
1845
25004
ICD-8 Finland
Diabetes mellitus, Nephropathia diabetica. Polyneuritis diabetica
+∞
13.6
13
*
E14.8
ICD-10 Finland
Unspecified diabetes mellitus, with unspecified complications
+∞
13.6
13
*
E10.0
ICD-10 Finland
Type 1 diabetes mellitus, With coma
+∞
13.6
13
*
E11.01
ICD-10 Finland
Non-insulin dependent diabetes diabetic coma with hyperglycaemia
+∞
13.6
13
*
2503A
ICD-9 Finland
Diabetes mellitus, Diabetes with other coma[SOKERITAUDIN AIHEUTTAMA MUNUAISSAIRAUS,TYYPPI II]
+∞
13.6
13
*
H360, E113,
ICD-10 Finland
+∞
13.6
13
*
3626
FHL
Extracapsular cataract surgery and implantation of an artificial lens
3.7
13.6
44
125
C07AB02
ATC
metoprolol; systemic
1.9
13.0
198
1184
M25.5
ICD-10 Finland
Pain in joint
0.3
12.8
32
1030
Z01.2
ICD-10 Finland
Dental examination
0.4
12.8
67
1494
4273A
ICD-9 Finland
Cardiac dysrhythmias, Atrial fibrillation and flutter
3.7
12.7
41
116
A02BC02
ATC
pantoprazole; systemic
0.5
12.7
218
3187
280
Kela drug reimbursment
Clopidogrel
4.6
12.7
30
67
I20.00
ICD-10 Finland
Unstable angina
3.6
12.7
43
126
315
Kela drug reimbursment
Clopidogrel
6.1
12.7
22
37
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
0.4
12.6
71
1539
SPAT1216
SPAT
Assessment of functional ability
0.2
12.6
14
751
2507X
ICD-9 Finland
Diabetes mellitus, Diabetes with peripheral circulatory disorders[DIABETES MELLITUS CUM COMPLICATIONE ALIA ,NUD]
+∞
12.5
12
*
M14.6*E11.6
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic neuropathic
+∞
12.5
12
*
N08.3
ICD-10 Finland
Glomerular disorders in diabetes mellitus
+∞
12.5
12
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.8
12.5
67
258
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
0.4
12.5
83
1681
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
0.2
12.4
13
727
A08.4
ICD-10 Finland
Viral intestinal infection, unspecified
3.9
12.3
36
95
L03
ICPC
Low back symptom/complaint
0.2
12.3
24
894
J01XX05
ATC
methenamine; oral
4.7
12.2
28
61
J01XE01
ATC
nitrofurantoin; oral
4.3
12.2
32
78
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
4.3
12.1
31
74
2780A
ICD-9 Finland
Obesity and other hyperalimentation, Obesity
27.3
12.1
16
6
C10AB04
ATC
gemfibrozil; oral
10.3
12.1
23
23
C02DE02, ,
ATC
4.1
12.1
33
83
I25.0
ICD-10 Finland
Atherosclerotic cardiovascular disease, so described
2.6
12.0
75
312
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
4.2
12.0
32
79
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
0.3
12.0
37
1066
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
0.3
12.0
35
1038
M54.5
ICD-10 Finland
Low back pain
0.4
11.9
54
1292
N03AF01
ATC
carbamazepine; oral, rectal
3.1
11.9
52
179
0093A
ICD-9 Finland
Ill-defined intestinal infections, Diarrhoea of presumed infectious origin
10.8
11.8
22
21
I21.99
ICD-10 Finland
Myocardial infarction (acute) UNS unspecified coronary artery status
3.2
11.8
48
158
S82
ICPC
Naevus/mole
0.1
11.8
*
400
SDA03
NOMESCO Finland
Periodontal treatment
0.3
11.7
43
1135
H13
ICPC
Plugged feeling ear
0.2
11.7
21
823
C03BA08
ATC
metolazone; oral
66.1
11.6
13
*
B04AC02, ,
ATC
19.3
11.6
17
9
SPAT1008
SPAT
Photography of fundus of the eye or interpretation of photograph
23.4
11.6
16
7
A10BK01
ATC
dapagliflozin; oral
23.4
11.6
16
7
I20.99
ICD-10 Finland
Angina pectoris, unspecified
2.5
11.6
76
324
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
0.3
11.6
25
879
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
0.3
11.5
43
1129
25005
ICD-8 Finland
Diabetes mellitus, Neuropathia diabetica. Polyneuritis diabetica
+∞
11.5
11
*
N02AC04
ATC
dextropropoxyphene; oral
2.9
11.5
57
211
61
HP
Catheterization and pressure measurement of the left side of the heart
4.3
11.4
29
69
Z49.0
ICD-10 Finland
Preparatory care for dialysis
15.4
11.4
18
12
H29
ICPC
Ear symptom/complaint other
0.1
11.3
6
435
C02AC05
ATC
moxonidine; oral
3.7
11.3
36
101
WVC10
NOMESCO Finland
Subcutaneous infusion of drugs
35.7
11.3
14
*
A12AA12
ATC
[U] calcium acetate
35.7
11.3
14
*
Z71.8
ICD-10 Finland
Other specified counselling
0.3
11.3
44
1131
C02CA01
ATC
prazosin; oral
4.1
11.1
31
79
7804A
ICD-9 Finland
General symptoms, Dizziness and giddiness
4.1
11.0
30
75
H81
ICPC
Excessive ear wax
0.2
11.0
21
798
I20.89
ICD-10 Finland
Other angina pectoris unspecified coronary artery status
3.1
10.9
47
160
D03BA02
ATC
collagenase; topical
15.8
10.9
17
11
L28
ICPC
Limited function/disability (L)
0.3
10.9
32
950
104
Kela drug reimbursment
Thyroid insufficiency
2.8
10.9
58
223
SPAT1310
SPAT
Counselling related to known health issue
0.3
10.9
40
1060
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
18.2
10.8
16
9
B04AB02, ,
ATC
3.6
10.7
35
100
Z94.0
ICD-10 Finland
Kidney transplant status
13.2
10.7
18
14
WW200, ,
SPAT
0.3
10.7
29
900
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.8
10.7
230
1519
I21.40
ICD-10 Finland
Acute subendocardial infarction no detected stenosis of the coronary artery
3.3
10.6
41
131
127
Kela drug reimbursment
Transplant complication
9.4
10.6
21
23
5253
FHL
Cardiac lung machine
4.9
10.5
23
48
R23.8
ICD-10 Finland
Other and unspecified skin changes
0.2
10.5
18
732
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
0.1
10.5
*
370
SPAT1312
SPAT
General health counselling
0.4
10.5
43
1086
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
0.2
10.5
13
653
I50.9
ICD-10 Finland
Heart failure, unspecified
1.9
10.5
177
1085
I20.01
ICD-10 Finland
Unstable angina
3.7
10.5
33
92
2500C
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,MODY]
+∞
10.4
10
*
A10BX02
ATC
repaglinide; oral
+∞
10.4
10
*
A10BD07
ATC
metformin and sitagliptin; systemic
+∞
10.4
10
*
G63.2
ICD-10 Finland
Diabetic polyneuropathy
+∞
10.4
10
*
K40.9
ICD-10 Finland
Unilateral or unspecified inguinal hernia, without obstruction or gangrene
0.2
10.4
15
680
I20.09
ICD-10 Finland
Unstable angina
2.6
10.2
62
254
D06AX01
ATC
fusidic acid; topical
2.4
10.2
74
330
B01AF01
ATC
rivaroxaban; oral
0.2
10.2
8
446
4340A
ICD-9 Finland
Occlusion of cerebral arteries, Cerebral thrombosis
4.3
10.2
26
62
SPAT1249
SPAT
Treatment-related counselling outside office
0.4
10.1
64
1340
4029A
ICD-9 Finland
Hypertensive heart disease, Unspecified[DECOMPENSATIO CORDIS NON INDICATA (WHO II)]
8.6
10.1
21
25
3661A
ICD-9 Finland
Cataract, Senile cataract
3.3
10.0
38
120
M01AE01
ATC
ibuprofen; systemic, rectal
0.6
9.8
332
4179
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
0.1
9.7
*
345
N06DX01
ATC
memantine; oral
0.2
9.7
15
650
PBL09
NOMESCO Finland
Construction of arteriovenous fistula from brachial artery
55.8
9.7
11
*
FNA01
NOMESCO Finland
Anastomosis to coronary artery from internal mammary artery, one distal anastamosis
2.9
9.7
47
172
M01AB05
ATC
diclofenac; systemic, rectal
0.6
9.6
194
2794
L15
ICPC
Knee symptom/complaint
0.3
9.6
21
737
WZC00
NOMESCO Finland
Treatment plan or consultation
0.4
9.6
59
1252
0088X
ICD-9 Finland
Intestinal infections due to other organisms, Other organism, not elsewhere classified
15.3
9.5
15
10
SPAT1254
SPAT
Administration of medicine
0.2
9.5
19
705
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
0.4
9.5
64
1311
NHS99
NOMESCO Finland
Other operation for infection of tendon, joint or bone of ankle or foot
101.4
9.4
10
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
0.4
9.4
51
1143
N02AX02
ATC
tramadol; systemic, rectal
1.7
9.4
267
1889
I20.90
ICD-10 Finland
Angina pectoris, unspecified
2.9
9.4
45
163
EBA00
NOMESCO Finland
Extraction of tooth
0.4
9.4
58
1232
SAA03
NOMESCO Finland
Extended examination of mouth
0.4
9.4
58
1232
4111X
ICD-9 Finland
Other acute and subacute forms of ischaemic heart disease, Intermediate coronary syndrome[PITKITTYNYT ANGINA PECTORIS -KOHTAUS,MÄÄRITTELEMÄT]
4.5
9.4
23
53
B01AB05
ATC
enoxaparin; parenteral
0.4
9.4
55
1193
ZPB22
NOMESCO Finland
Autograft of vein
12.6
9.4
16
13
H28.0*E10.3
ICD-10 Finland
Other specified diabetes mellitus - Diabetic cataract
+∞
9.4
9
*
N0830, E112,
ICD-10 Finland
+∞
9.4
9
*
H3602, E113,
ICD-10 Finland
+∞
9.4
9
*
CK2S4, ,
SPAT
+∞
9.4
9
*
2508A
ICD-9 Finland
Diabetes mellitus, Diabetes with other specified manifestations[DIABETES MELLITUS CUM COMPLICAT NON DESCR,TYP II]
+∞
9.4
9
*
QXA20
NOMESCO Finland
Skin abrasion, unspecified location
+∞
9.4
9
*
SFA30
NOMESCO Finland
Three-surface restoration
0.4
9.4
61
1268
L13
ICPC
Hip symptom/complaint
0.2
9.3
16
651
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
0.4
9.3
65
1316
SDA02
NOMESCO Finland
Periodontal treatment, brief
0.4
9.3
48
1096
N05CD07
ATC
temazepam; oral
1.9
9.2
128
734
-1, ,
NOMESCO Finland
0.4
9.2
45
1054
C03BA11
ATC
indapamide; oral
3.7
9.2
29
81
B01AF02
ATC
apixaban; oral
0.2
9.2
10
550
SPAT1304
SPAT
Counselling and guidance related to ageing
0.1
9.1
5
353
B04AC04, ,
ATC
8.5
9.1
19
23
G04BX05, ,
ATC
8.5
9.1
19
23
V03AE02
ATC
sevelamer; oral
37.2
9.0
11
*
Z51.5
ICD-10 Finland
Palliative care
0.2
9.0
9
432
41399
ICD-8 Finland
Angina pectoris, Without mention of hypertensive disease
4.0
8.9
25
64
C08CA05
ATC
nifedipine; systemic
2.3
8.8
66
299
Z76.0
ICD-10 Finland
Issue of repeat prescription
0.3
8.8
24
747
82
HP
Single vessel balloon catheter extension
3.7
8.8
28
79
A10BK03
ATC
empagliflozin; oral
14.3
8.7
14
10
A04
ICPC
Weakness/tiredness general
0.3
8.7
23
728
R05
ICPC
Cough
0.3
8.7
31
841
K03.64
ICD-10 Finland
Dental calculus supragingival
0.4
8.6
35
895
D19
ICPC
Teeth/gum symptom/complaint
0.4
8.6
35
894
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
16.5
8.6
13
8
I21.49
ICD-10 Finland
Acute subendocardial infarction unspecified coronary artery status
2.3
8.5
64
290
PFH59
NOMESCO Finland
Bypass from femoral or popliteal artery to distal anterior tibial artery
27.9
8.5
11
*
SPAT1222
SPAT
Counselling/guidance promoting independent living
0.3
8.5
22
705
WX320
NOMESCO Finland
Spinalanesthesy
0.4
8.4
39
938
C02LM02, ,
ATC
4.7
8.4
19
41
D82
ICPC
Teeth/gum disease
0.4
8.4
50
1081
6480A
ICD-9 Finland
Other current conditions in the mother classifiable elsewhere but complicating pregnancy, childbirth and the puerperium, Diabetes mellitus
+∞
8.3
8
*
M14.6*E10.6
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic neuropathic
+∞
8.3
8
*
O24.1
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, non-insulin-dependent
+∞
8.3
8
*
N0830, E102,
ICD-10 Finland
+∞
8.3
8
*
A10BH05
ATC
linagliptin; oral
+∞
8.3
8
*
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
+∞
8.3
8
*
SPAT1100
SPAT
Long-term monitoring of blood pressure
0.1
8.3
*
290
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
0.5
8.3
114
1851
L82
ICD-10 Finland
Seborrhoeic keratosis
0.2
8.3
15
593
JAB30
NOMESCO Finland
Repair of inguinal hernia using prosthetic material
0.2
8.3
10
514
L04AA01
ATC
[U] ciclosporin
9.6
8.3
16
17
R05FB02
ATC
cough suppressants and expectorants; systemic
1.6
8.3
247
1758
Z01.1
ICD-10 Finland
Examination of ears and hearing
0.2
8.2
16
605
C02EA03, ,
ATC
4.6
8.2
19
42
C03AA03
ATC
hydrochlorothiazide; oral
2.1
8.1
77
385
A03FA02
ATC
cisapride; oral, rectal
2.2
8.1
73
358
SDA01
NOMESCO Finland
Periodontal treatment, very brief
0.4
8.0
31
813
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
0.3
8.0
29
782
A29
ICPC
General symptom/complaint other
0.2
8.0
13
547
CKC12
NOMESCO Finland
Photocoagulation of retina
3.7
7.9
25
70
L17
ICPC
Foot/toe symptom/complaint
0.4
7.9
45
993
K78
ICPC
Atrial fibrillation/flutter
0.2
7.9
7
362
WX290
NOMESCO Finland
Other blockage of nerve
0.5
7.9
72
1331
C10AA02
ATC
lovastatin; oral
2.5
7.8
48
198
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
0.2
7.8
6
342
H02
ICPC
Hearing complaint
0.3
7.8
18
616
R74
ICPC
Upper respiratory infection acute
0.4
7.8
40
923
4140X
ICD-9 Finland
Other forms of chronic ischaemic heart disease, Coronary atherosclerosis[ATHEROSCLEROSIS ARTER CORON CORDIS,MÄÄRITTELEMÄT]
6.5
7.8
19
30
M01AC06
ATC
meloxicam; systemic, rectal
0.5
7.7
81
1434
V03AE03
ATC
lanthanum carbonate; oral
45.5
7.7
9
*
M09AA72
ATC
quinine, combinations with psycholeptics; systemic
2.5
7.7
49
206
42792
ICD-8 Finland
Symptomatic heart disease, Fibrillatio auricularis
4.6
7.7
18
40
A11
ICPC
Chest pain NOS
0.1
7.7
*
273
N06DA02
ATC
donepezil; oral
0.2
7.6
11
502
G30.1
ICD-10 Finland
Alzheimer disease with late onset
0.3
7.6
19
624
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
8.2
7.6
16
20
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
18.6
7.6
11
6
D03AX01
ATC
cadexomer iodine; topical
18.6
7.6
11
6
7870A
ICD-9 Finland
Symptoms involving digestive system, Nausea and vomiting
18.6
7.6
11
6
M01AX05
ATC
glucosamine; oral
0.4
7.6
34
833
TBW99
NOMESCO Finland
Other minor procedure in endocrine surgery
25.3
7.6
10
*
9571
FHL
Amputation of toe or toes
25.3
7.6
10
*
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
3.9
7.6
22
58
204
Kela drug reimbursment
Leukemia lymphatica
3.1
7.6
31
103
C07AB05
ATC
betaxolol; oral
3.3
7.5
28
88
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
0.6
7.4
108
1734
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
6.1
7.4
19
32
N39.4
ICD-10 Finland
Other specified urinary incontinence
0.2
7.4
6
326
A01
ICPC
Pain general/multiple sites
0.2
7.4
6
327
K03.82
ICD-10 Finland
Split tooth for reasons other than trauma
0.3
7.3
25
697
BEF00, ,
SPAT
+∞
7.3
7
*
3620A
ICD-9 Finland
Other retinal disorders, Diabetic retinopathy[RETINOPATHIA DIABETICA NON PROLIFERATIVA]
+∞
7.3
7
*
A10BJ06
ATC
semaglutide; parenteral
+∞
7.3
7
*
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
+∞
7.3
7
*
5901A
ICD-9 Finland
Infections of kidney, Acute pyelonephritis
6.3
7.3
18
29
I21.3
ICD-10 Finland
Acute transmural myocardial infarction of unspecified site
15.9
7.2
11
7
A97
ICPC
No disease
0.3
7.2
27
719
4140B
ICD-9 Finland
Other forms of chronic ischaemic heart disease, Coronary atherosclerosis[ATHEROSCLEROSIS ARTER CORON CORDIS,AHTAUTUNUT]
4.0
7.2
20
51
E78.0
ICD-10 Finland
Pure hypercholesterolaemia
0.3
7.2
20
619
R01AD09
ATC
mometasone; nasal
0.5
7.2
89
1500
C08CA07
ATC
nisoldipine; oral
3.5
7.2
24
70
R96
ICPC
Asthma
0.1
7.2
*
258
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.7
7.2
39
152
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
0.5
7.1
83
1427
C07AA07
ATC
sotalol; systemic
2.4
7.1
47
201
L57.0
ICD-10 Finland
Actinic keratosis
0.3
7.1
15
541
4380A
ICD-9 Finland
Late effects of cerebrovascular disease[SEQUELAE MORBI CEREBROVASCULARIS]
8.9
7.1
14
16
M16.9
ICD-10 Finland
Coxarthrosis, unspecified
0.1
7.1
*
230
00920
ICD-8 Finland
Diarrhoeal disease, Gastroenteritis (acuta) (infectiosa)
4.4
7.0
17
39
Z01.7
ICD-10 Finland
Laboratory examination
0.2
6.9
13
501
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.6
6.9
182
1248
M03BX02
ATC
tizanidine; oral
0.6
6.9
145
2117
C10AA01
ATC
simvastatin; oral
1.5
6.8
263
1968
N05AA02
ATC
levomepromazine; systemic
3.0
6.8
29
99
3792A
ICD-9 Finland
Other disorders of eye, Disorders of vitreous body
40.5
6.8
8
*
7071A
ICD-9 Finland
Chronic ulcer of skin, Ulcer of lower limbs, except decubitus
40.5
6.8
8
*
K04.5
ICD-10 Finland
Chronic apical periodontitis
0.4
6.7
34
793
Z00.0
ICD-10 Finland
General medical examination
0.4
6.7
31
751
SCA01
NOMESCO Finland
Preventive oral health care, short
0.4
6.7
43
909
M70.6
ICD-10 Finland
Trochanteric bursitis
0.2
6.7
9
360
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
0.2
6.6
10
443
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
0.3
6.6
13
489
E78.29
ICD-10 Finland
Other mixed hyperlipidaemia
12.4
6.6
11
9
0092A
ICD-9 Finland
Ill-defined intestinal infections, Infectious diarrhoea
12.4
6.6
11
9
I22.99
ICD-10 Finland
Recurrent infarction with unspecified location unspecified coronary artery status
12.4
6.6
11
9
4110X
ICD-9 Finland
Other acute and subacute forms of ischaemic heart disease, Postmyocardial infarction syndrome[EPÄSTABIILI ANGINA PECTORIS,MÄÄRITTELEMÄT]
6.9
6.5
15
22
PF1AT
NOMESCO Finland
Intravascular dilatation of arteries of knee, lower leg and ankle (PTA)
6.9
6.5
15
22
G04CB02
ATC
dutasteride; oral
0.2
6.5
8
343
Z34.8
ICD-10 Finland
Supervision of other normal pregnancy
0.1
6.5
*
220
S29
ICPC
Skin symptom/complaint other
0.3
6.5
23
631
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
6.3
6.5
16
26
C02DE10, ,
ATC
3.6
6.5
21
60
SFA40
NOMESCO Finland
Restoration involving the entire crown of the tooth
0.3
6.4
23
628
R02
ICPC
Shortness of breath/dyspnoea
0.2
6.4
11
450
Z96.4
ICD-10 Finland
Presence of endocrine implants
70.5
6.4
7
*
I20.80
ICD-10 Finland
Other angina pectoris no detected stenosis of coronary artery
4.1
6.4
17
42
S12
ICPC
Insect bite/sting
0.2
6.3
*
257
A10BG02
ATC
rosiglitazone; oral
+∞
6.3
6
*
CL2S4, ,
SPAT
+∞
6.3
6
*
E11.09
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - With coma
+∞
6.3
6
*
37700
ICD-8 Finland
Other diseases of retina and optic nerve, Haemorrhagia corporis vitrei
+∞
6.3
6
*
2508B
ICD-9 Finland
Diabetes mellitus, Diabetes with other specified manifestations[DIABETES MELLITUS CUM COMPLICAT NON DESCR,TYP I]
+∞
6.3
6
*
2506X
ICD-9 Finland
Diabetes mellitus, Diabetes with neurological manifestations[MICROANGIOPATHIA DIABETICA,NUD]
+∞
6.3
6
*
25007
ICD-8 Finland
Diabetes mellitus, Coma diabeticum
+∞
6.3
6
*
N08.30
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
+∞
6.3
6
*
A10AB06
ATC
insulin glulisine; parenteral
+∞
6.3
6
*
N0832, E102,
ICD-10 Finland
+∞
6.3
6
*
0350X
ICD-9 Finland
Erysipelas[ERYSIPELAS ALIA DEFINITA SEU NUD]
7.1
6.2
14
20
QDG00
NOMESCO Finland
Debridement of bedsore of lower limb
26.9
6.2
8
*
4120C
ICD-9 Finland
Old myocardial infarction[STATUS POST INFARCTUM CORDIS,TROMBI]
26.9
6.2
8
*
XX3DW
NOMESCO Finland
Time consuming IT work
0.2
6.2
8
334
A44
ICPC
General and Unspecified, Preventive immunization/medic
0.2
6.2
5
274
5313
FHL
Bypass surgery for three vessels
6.4
6.2
15
24
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
0.5
6.2
54
1023
U04
ICPC
Incontinence urine
0.2
6.2
*
251
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
0.3
6.2
16
514
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
0.2
6.1
6
290
3643
FHL
Vitrectomy through pars Plana
12.7
6.1
10
8
I20.19
ICD-10 Finland
Angina angiospastic
12.7
6.1
10
8
A02BA03
ATC
famotidine; systemic
2.4
6.1
39
165
41099
ICD-8 Finland
Acute myocardial infarction, Without mention of hypertensive disease
3.7
6.1
19
53
G04BD12
ATC
mirabegron; oral
0.2
6.1
11
434
L04AA06
ATC
mycophenolic acid; systemic
6.8
6.1
14
21
41300
ICD-8 Finland
Angina pectoris, Cum hypertonia
6.8
6.1
14
21
WZA90
NOMESCO Finland
Other medical or dental certificate
0.4
6.1
27
665
G04BE01
ATC
alprostadil; parenteral, urethral
3.5
6.0
20
58
SPAT1260
SPAT
Consultation of another employee
0.3
6.0
21
581
J81
ICD-10 Finland
Pulmonary oedema
6.1
6.0
15
25
R53
ICD-10 Finland
Malaise and fatigue
0.5
6.0
76
1281
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
169
4601
0.16
107.79
39.2
25.5
7.17
6.88
e9/l
0.77
159
4462
169
4600
0.16
107.70
39.0
25.5
4.38
4.37
e12/l
0.10
159
4464
169
4599
0.16
107.61
39.3
25.5
255.04
238.91
e9/l
2.03
161
4472
156
4358
0.17
96.24
15.6
10.6
24.54
24.47
u/l
0.02
147
4182
151
4313
0.16
96.04
28.9
17.7
24.04
28.76
mg/l
1.41
122
3614
111
3849
0.15
88.61
5.3
4.2
8.22
5.60
mmol/l
9.22
94
3405
168
4351
0.18
87.84
35.9
20.8
4.07
4.00
mmol/l
2.24
163
4225
143
3808
0.21
67.02
25.4
16.7
75.70
74.36
ml/min/173m2
0.19
128
3525
158
3873
0.23
62.56
7.5
4.8
2.20
2.66
mmol/l
11.57
150
3464
151
3771
0.23
60.63
7.3
4.6
2.09
2.00
mu/l
0.13
143
3381
157
3764
0.24
57.14
6.8
4.3
4.08
4.52
mmol/l
8.18
150
3387
121
3380
0.22
56.00
10.8
7.2
95.86
85.04
u/l
0.74
115
3148
157
3727
0.25
55.21
6.8
4.2
1.48
1.46
mmol/l
0.22
149
3329
109
3191
0.22
53.05
6.0
4.1
16.55
13.24
mm/h
1.10
103
2905
148
3539
0.26
50.32
5.4
3.6
1.13
1.15
mmol/l
0.16
139
3129
161
3640
0.27
48.95
13.8
4.2
54.59
36.55
mmol/mol
40.73
152
3278
131
3080
0.29
38.15
5.8
3.7
14.90
14.95
pmol/l
0.09
123
2745
100
2514
0.29
30.25
12.9
8.7
4.37
4.23
e9/l
0.23
86
2155
87
2359
0.28
30.22
7.3
5.9
11.99
13.72
umol/l
0.58
81
2227
34
1670
0.16
30.13
2.8
5.9
3.39
3.73
ug/l
0.08
28
1460
65
2046
0.25
28.88
2.3
2.2
90.47
93.14
pmol/l
0.14
35
1097
89
2337
0.29
28.70
5.9
4.3
0.22
0.58
estimate
0.26
23
514
89
2334
0.29
28.60
5.9
4.2
0.00
3.16
estimate
0.50
24
516
88
2289
0.29
27.54
5.9
4.2
0.00
0.00
estimate
0.50
26
498
104
2428
0.32
25.93
19.4
6.8
1.20
1.21
mmol/l
1.04
95
2053
64
1920
0.26
25.33
6.5
4.0
96.96
44.74
ng/l
0.65
55
1416
104
2366
0.34
24.02
3.5
3.0
—
—
—
0
0
26
1339
0.16
23.54
2.9
4.8
24.30
22.16
%
0.33
12
707
83
2034
0.33
21.65
3.6
2.8
—
—
estimate
—
0
0
36
1415
0.21
21.55
1.9
1.7
23.71
19.58
nmol/l
0.63
28
1191
24
7
35.46
19.00
1.4
1.0
100.43
—
iu/ml
—
7
0
71
1754
0.34
18.03
6.0
4.3
0.00
0.05
estimate
2.54
22
415
80
1850
0.36
17.60
5.8
3.6
—
—
—
0
0
17
967
0.15
16.96
1.8
3.5
0.77
0.86
ug/l
0.31
12
661
92
1912
0.40
15.43
3.8
2.4
71.07
77.36
nmol/l
1.96
85
1687
58
1450
0.34
14.49
6.7
3.6
0.54
0.48
e6/l
0.08
44
1100
54
1386
0.34
14.19
2.6
2.3
2.95
2.88
mg/l
0.09
48
1160
22
15
15.11
13.65
3.0
3.1
9.40
66.50
ug/min
—
10
6
31
1021
0.27
12.93
7.9
4.2
387.03
333.52
ng/l
0.08
26
871
48
1213
0.35
11.92
5.6
3.8
0.00
0.09
estimate
0.74
22
388
59
1333
0.39
11.38
6.4
4.3
0.00
0.01
estimate
0.69
24
444
33
969
0.31
10.98
1.8
1.7
492.11
7566651.53
pmol/l
0.50
27
793
41
1069
0.34
10.75
5.9
4.4
1.02
1.02
kg/l
0.15
28
706
138
788
1.94
10.13
7.0
2.3
12.75
35.83
mg/mmol
0.44
107
443
31
900
0.31
10.02
3.9
3.3
0.71
1.19
e6/l
0.56
12
509
49
1139
0.39
9.92
3.2
2.5
—
—
—
0
0
38
976
0.35
9.55
1.6
1.9
—
—
—
0
0
30
861
0.32
9.44
3.7
3.5
3.57
2.11
e6/l
0.51
11
471
38
923
0.38
8.37
1.7
2.1
1.40
1.49
mg/l
0.09
32
723
25
741
0.31
8.32
1.7
1.8
—
—
—
0
0
25
714
0.33
7.72
1.7
1.8
—
—
—
0
0
9
381
0.23
7.25
1.0
1.7
—
—
—
0
0
17
554
0.29
6.73
16.5
8.1
—
—
—
0
0
135
870
1.69
6.44
6.0
2.6
7.30
7.64
mmol/l
0.46
125
733
23
613
0.35
6.13
1.3
1.3
12.97
26.22
iu/ml
—
9
187
21
568
0.35
5.77
1.5
1.3
1.40
12.32
u/ml
—
8
213
26
601
0.41
5.02
1.7
1.7
—
—
—
0
0
85
1324
0.59
4.93
3.2
1.8
1.08
1.19
mmol/l
1.16
80
1124
17
470
0.35
4.90
4.6
3.2
848.51
320.63
ng/l
1.51
17
434
9
291
0.30
4.46
1.6
1.6
—
—
—
0
0
0
106
0.00
4.24
0.0
1.3
—
—
—
0
0
9
281
0.31
4.19
1.2
1.4
—
—
—
0
0
17
424
0.39
3.94
7.1
2.3
25.44
31.53
u/l
—
9
356
12
340
0.34
3.67
2.4
2.3
—
—
—
0
0
45
760
0.56
3.49
3.2
2.6
29.58
30.01
s
0.30
45
739
5
194
0.25
3.42
1.2
1.7
—
—
—
0
0
11
312
0.34
3.39
2.2
2.2
—
—
—
0
0
19
408
0.45
3.09
2.6
2.3
0.21
0.65
e6/l
2.15
19
389
24
461
0.50
2.86
15.4
7.1
1.28
1.40
mmol/l
0.41
24
448
34
582
0.56
2.78
10.8
6.3
-0.22
1.21
mmol/l
0.87
26
469
5
6
8.38
2.75
4.0
2.0
0.66
0.59
mmol/l
—
5
6
0
69
0.00
2.61
0.0
1.1
—
11.56
—
0
19
6
180
0.33
2.57
1.3
2.1
—
—
—
0
0
0
67
0.00
2.40
0.0
1.1
—
2.53
—
0
10
18
349
0.50
2.25
1.6
1.5
—
—
—
0
0
9
212
0.42
2.22
1.2
1.9
—
—
—
0
0
7
182
0.38
2.18
1.0
1.1
—
—
—
0
0
15
302
0.49
2.11
14.5
8.5
22.67
24.61
mmol/l
0.99
15
290
8
190
0.41
2.08
1.3
1.3
—
—
—
0
0
7
178
0.39
2.05
2.9
2.8
19.14
59.17
u/ml
—
7
172
33
520
0.62
2.00
4.6
3.9
—
—
—
0
0
17
312
0.53
1.83
12.2
8.9
94.49
93.72
%
0.34
17
312
6
151
0.39
1.78
1.0
2.0
—
—
—
0
0
5
137
0.36
1.76
1.0
1.2
—
—
—
0
0
0
46
0.00
1.71
0.0
1.6
—
—
—
0
0
29
449
0.63
1.66
12.0
6.9
118.10
119.92
g/l
0.18
29
437
6
146
0.41
1.66
1.2
1.4
—
—
—
0
0
6
146
0.41
1.66
1.2
1.4
—
—
—
0
0
11
221
0.49
1.58
1.7
1.9
0.78
2.71
ug/l
0.78
11
187
24
380
0.62
1.53
2.0
1.7
—
—
—
0
0
0
44
0.00
1.51
0.0
1.3
—
—
—
0
0
5
16
3.14
1.44
2.2
1.4
6.72
8.11
mmol/l
—
5
16
5
121
0.41
1.38
2.6
1.7
—
—
—
0
0
18
293
0.60
1.31
9.8
3.1
122.44
124.96
g/l
0.15
18
284
6
127
0.47
1.17
2.7
1.9
1.44
3.82
mg/l
—
6
88
10
184
0.54
1.15
2.5
2.1
125.80
660.11
ug/l
—
10
172
0
36
0.00
1.14
0.0
1.3
—
—
—
0
0
5
113
0.44
1.13
1.6
1.5
309.80
300.36
mu/l
—
5
104
7
140
0.49
1.10
1.4
1.7
—
—
—
0
0
11
188
0.58
1.00
2.9
2.9
—
—
—
0
0
13
211
0.61
0.98
12.7
3.5
24.77
25.08
mmol/l
0.08
13
202
0
29
0.00
0.98
0.0
1.0
—
38.91
—
0
14
0
29
0.00
0.98
0.0
1.0
—
504.60
—
0
15
0
30
0.00
0.97
0.0
2.3
—
13.35
—
0
30
0
31
0.00
0.96
0.0
3.3
—
63.14
—
0
31
0
31
0.00
0.96
0.0
1.6
—
6.86
—
0
24
21
305
0.68
0.96
8.1
6.3
0.59
2.18
mmol/l
1.13
14
231
0
32
0.00
0.95
0.0
1.2
—
9.04
—
0
11
0
32
0.00
0.95
0.0
1.1
—
—
—
0
0
11
182
0.60
0.90
1.6
1.3
—
—
—
0
0
5
101
0.49
0.90
1.6
1.2
—
—
—
0
0
17
249
0.67
0.83
14.6
9.0
15.95
15.64
%
0.16
17
237
25
341
0.72
0.83
14.0
4.4
196.08
83.38
ng/l
2.40
25
287
35
450
0.77
0.79
10.1
4.5
5.24
4.67
kpa
0.57
35
444
5
98
0.51
0.78
1.0
1.1
—
10.87
—
0
11
6
107
0.56
0.73
1.0
1.9
545.83
459.65
mg/l
—
6
101
13
194
0.66
0.72
7.2
7.3
23.94
24.94
mmol/l
1.33
13
179
15
216
0.69
0.70
1.4
1.3
—
44.49
—
0
17
7
121
0.57
0.67
2.0
1.6
—
—
—
0
0
5
95
0.52
0.66
2.8
1.6
—
—
—
0
0
8
131
0.61
0.64
1.4
1.7
—
—
—
0
0
6
103
0.58
0.62
1.3
1.3
—
—
—
0
0
0
22
0.00
0.59
0.0
1.0
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
22
0.00
0.59
0.0
1.1
—
—
—
0
0
0
23
0.00
0.58
0.0
2.1
—
—
—
0
0
0
23
0.00
0.58
0.0
1.2
—
169.76
—
0
23
0
23
0.00
0.58
0.0
1.6
—
—
—
0
0
52
612
0.84
0.57
20.6
6.0
1.19
1.06
mmol/l
1.82
52
557
10
147
0.68
0.54
3.8
4.4
2.58
3.50
g/l
—
10
142
18
135
1.34
0.51
2.7
1.6
—
—
—
0
0
14
191
0.73
0.51
1.4
1.3
240.51
103.51
u/ml
—
7
68
7
108
0.64
0.49
1.4
1.7
—
—
—
0
0
45
526
0.85
0.48
10.9
4.5
5.95
5.84
kpa
0.35
45
515
8
119
0.67
0.46
1.8
1.4
—
—
—
0
0
6
91
0.66
0.42
1.0
1.9
4.40
3.47
mmol/l
—
6
85
0
15
0.00
0.41
0.0
1.1
—
71.11
—
0
9
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
16
0.00
0.41
0.0
2.8
—
136.63
—
0
16
0
16
0.00
0.41
0.0
2.1
—
7.63
—
0
16
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
0
17
0.00
0.40
0.0
1.1
—
158.04
—
0
17
7
102
0.68
0.40
1.7
1.3
—
—
—
0
0
15
193
0.77
0.39
7.2
3.7
1.47
1.56
%
0.23
15
177
0
19
0.00
0.39
0.0
1.4
—
—
—
0
0
0
19
0.00
0.39
0.0
2.6
—
231.37
—
0
19
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
9
66
1.37
0.38
1.1
1.8
—
—
—
0
0
11
86
1.28
0.26
2.1
1.8
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
15
180
0.83
0.24
3.4
3.6
0.37
0.37
iu/ml
—
9
102
80
855
0.93
0.23
2.4
1.3
3.80
1.37
u/ml
0.47
24
207
5
39
1.28
0.23
1.6
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
2.5
—
1.81
—
0
11
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
40.27
—
0
12
0
12
0.00
0.21
0.0
1.0
—
93.08
—
0
12
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
13
0.00
0.21
0.0
1.3
—
96.54
—
0
13
0
13
0.00
0.21
0.0
1.0
—
1420.77
—
0
13
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
343.86
—
0
7
0
13
0.00
0.21
0.0
3.5
—
172.08
—
0
13
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
16.67
—
0
9
38
408
0.93
0.14
23.4
7.2
14.52
10.43
mmol/l
1.98
38
392
10
84
1.19
0.14
8.6
3.2
19.92
9.75
pmol/l
—
10
84
13
146
0.89
0.10
21.3
10.8
2.24
1.47
mg/l
1.06
13
130
6
74
0.81
0.07
1.5
1.7
—
—
—
0
0
6
74
0.81
0.07
1.5
1.6
—
—
—
0
0
7
84
0.83
0.07
3.3
3.6
44533.57
560.31
u/ml
—
7
78
6
63
0.95
0.00
1.2
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
4.48
—
0
9
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
7.18
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
25.22
—
0
9
5
52
0.96
-0.00
3.0
3.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
10.06
—
0
9
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
60.40
—
0
5
5
49
1.02
-0.00
1.6
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
0.20
—
0
7
0
8
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint T1D_WIDE2 and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| T1D_WIDE2 | 6.681 [5.35, 8.35] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.368 |
During the follow-up period (1.1.1998 — 31.12.2019), 331 out of 651 females with T1D_WIDE2 died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| T1D_WIDE2 | 7.376 [6.0, 9.07] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 592 out of 1001 males with T1D_WIDE2 died.
Mortality risk
Mortality risk for people of age
years, who have T1D_WIDE2.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.619% | 1.217% |
| 5 | 4.152% | 8.264% |
| 10 | 9.596% | 19.66% |
| 15 | 17.983% | 34.211% |
| 20 | 28.735% | 51.143% |
Relationships between endpoints
↥Index endpoint: T1D_WIDE2 – Type 1 diabetes, wide definition, subgroup 2
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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