hypospadias: Hypospadias is the displacement of the urethral meatus on the ventrum of the penis. This abnormality is associated with a varyingly bent, twisted penis and opened dorsal prepuce.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleonly males |
244368 |
2. Check conditionsNone |
244368 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
152 |
4. Check minimum number of eventsNone |
152 |
5. Include endpointsNone |
152 |
6. Filter based on genotype QC (FinnGen only) |
134 |
Control definitions (FinnGen only)
- Control exclude
- Q17_CONGEN_MALFO_GENITAL_ORGANS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF12
- Parent code in ICD-10
- Q5
- Name in latin
- Hypospadia
Similar endpoints
↥List of similar endpoints to
Hypospadias
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of genital organs
- Congenital malformations, deformations and chromosomal abnormalities
- Congenital malformations, deformations and chromosomal abnormalities, including avohilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded (different definition than used in FinnGen).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 134 | - | 134 |
| Unadjusted period prevalence (%) | 0.06 | - | 0.06 |
| Median age at first event (years) | 10.60 | - | 10.60 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 146
- Matched controls
- 1460
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q54.0
ICD-10 Finland
Hypospadias, balanic
+∞
92.9
79
*
XKD00
NOMESCO Finland
Uroflowmetry
11.1
46.7
69
109
Q54.9
ICD-10 Finland
Hypospadias, unspecified
+∞
45.2
41
*
Q54.1
ICD-10 Finland
Hypospadias, penile
+∞
41.7
38
*
KGH61
NOMESCO Finland
Correction of distal hypospadia
+∞
40.5
37
*
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
10.0
39.2
58
90
UKC02
NOMESCO Finland
Cystoscopy
8.2
29.2
48
82
Q54.2
ICD-10 Finland
Hypospadias, penoscrotal
+∞
21.4
20
*
Q54.4
ICD-10 Finland
Congenital chordee
+∞
18.1
17
*
J01EA01
ATC
trimethoprim; systemic
7.0
16.4
28
48
TKD00
NOMESCO Finland
Dilatation of urethra
89.3
14.9
16
*
7526B
ICD-9 Finland
Congenital anomalies of genital organs, Hypospadias and epispadias[HYPOSPADIA]
+∞
14.8
14
*
ZXE10
NOMESCO Finland
More than one and less than three hours
3.9
14.5
68
268
N35.9
ICD-10 Finland
Urethral stricture, unspecified
59.4
14.1
16
*
KGH62
NOMESCO Finland
Total correction of proximal hypospadia
+∞
11.6
11
*
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
5.8
10.7
21
41
KDH70
NOMESCO Finland
Plastic repair of stricture of urethra
+∞
10.5
10
*
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
5.5
9.6
20
41
KDH10
NOMESCO Finland
Meatoplasty of urethra
+∞
9.5
9
*
ZXD10
NOMESCO Finland
Scheduled procedure
2.9
9.0
65
316
N30.0
ICD-10 Finland
Acute cystitis
8.8
8.7
18
23
WX308
NOMESCO Finland
Sacral anesthesy
21.6
8.6
12
6
N35.8
ICD-10 Finland
Other urethral stricture
95.3
8.5
9
*
7421
FHL
Single-stage total correction, in distal hypospadia
+∞
8.4
8
*
KFH00
NOMESCO Finland
Operation for undescended or ectopic testis
+∞
8.4
8
*
75220
ICD-8 Finland
Congenital anomalies of genital organs, Hypospadia glandis
+∞
8.4
8
*
N99.1
ICD-10 Finland
Postprocedural urethral stricture
+∞
8.4
8
*
Q53.2
ICD-10 Finland
Undescended testicle, bilateral
+∞
7.3
7
*
KGH69
NOMESCO Finland
Other correction of hypospadia
+∞
7.3
7
*
KGH20
NOMESCO Finland
Correction of induration or curvature of penis
+∞
7.3
7
*
KDV12
NOMESCO Finland
Urethroscopic internal urethrotomy
31.7
7.2
9
*
121
Kela drug reimbursment
Severe hypofunction of sexual glands
31.7
7.2
9
*
J01MA02
ATC
ciprofloxacin; systemic
2.8
7.2
48
219
Q53.1
ICD-10 Finland
Undescended testicle, unilateral
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
7
16
4.54
2.50
9.7
4.9
7.77
10.06
pmol/l
—
7
16
46
310
1.71
2.22
2.0
1.9
91.63
94.26
pmol/l
0.16
29
167
41
268
1.74
2.20
4.9
2.5
0.00
0.00
estimate
-0.00
18
83
52
383
1.56
1.71
6.0
3.7
—
—
—
0
0
50
366
1.56
1.69
5.2
2.9
0.00
0.00
estimate
-0.00
16
93
45
322
1.57
1.67
6.3
3.5
0.27
0.22
e6/l
0.17
39
234
65
505
1.52
1.67
5.2
3.4
0.00
0.00
estimate
-0.00
20
103
65
509
1.50
1.59
5.2
3.4
0.00
0.00
estimate
-0.00
19
91
5
15
3.41
1.53
5.4
6.1
1.80
3.44
ug/l
—
5
15
63
501
1.45
1.39
5.3
3.3
0.00
0.00
estimate
-0.00
19
107
15
83
1.90
1.37
2.9
3.1
—
—
—
0
0
36
257
1.53
1.33
6.0
3.3
0.00
0.01
estimate
0.49
20
94
24
161
1.59
1.16
12.2
12.7
105.83
104.66
mmol/l
0.75
24
161
5
20
2.55
1.16
1.4
1.1
281.40
201.47
pmol/l
—
5
20
63
521
1.37
1.05
11.3
11.8
1.24
1.21
mmol/l
1.70
57
477
5
22
2.32
1.04
4.6
2.3
199.80
167.97
ug/min
—
5
14
0
29
0.00
0.99
0.0
1.2
—
27.00
—
0
5
20
134
1.57
0.98
2.1
2.1
372.15
341.77
nmol/l
0.29
20
126
89
783
1.35
0.97
3.7
3.1
14.66
15.02
pmol/l
0.74
79
714
11
63
1.81
0.93
22.5
20.8
25.18
23.79
mmol/l
1.57
11
63
0
24
0.00
0.80
0.0
1.5
—
1.23
—
0
12
0
28
0.00
0.77
0.0
1.4
—
—
—
0
0
5
24
2.12
0.75
2.0
1.7
—
—
—
0
0
26
196
1.40
0.74
1.7
2.1
1.36
1.47
%
0.32
20
178
12
76
1.63
0.74
21.3
18.2
0.52
0.68
%
1.14
12
76
12
77
1.61
0.71
21.3
18.0
0.90
1.56
%
2.71
12
77
103
948
1.29
0.69
4.1
3.8
2.02
2.02
mu/l
0.01
97
880
7
43
1.66
0.68
3.0
6.2
54.33
56.73
%
—
7
43
48
404
1.28
0.67
3.8
3.5
—
—
estimate
—
0
0
47
396
1.28
0.64
2.3
2.1
1.39
1.42
mmol/l
0.09
38
349
26
202
1.35
0.63
7.0
8.4
0.84
0.82
mmol/l
0.37
26
197
11
72
1.57
0.61
23.2
19.2
96.64
93.75
%
1.92
11
72
0
21
0.00
0.60
0.0
1.2
—
2.00
—
0
11
0
21
0.00
0.60
0.0
1.2
—
2.00
—
0
16
80
722
1.24
0.60
7.8
14.5
3.77
3.89
e9/l
0.21
68
616
0
22
0.00
0.60
0.0
2.9
—
0.00
—
0
22
0
22
0.00
0.60
0.0
1.1
—
—
—
0
0
0
23
0.00
0.59
0.0
1.4
—
—
—
0
0
9
59
1.56
0.56
4.8
14.6
1.06
1.53
%
—
9
59
26
208
1.30
0.53
5.4
3.2
0.55
0.69
e6/l
0.20
17
113
25
201
1.29
0.49
5.5
3.6
1.66
0.69
e6/l
0.41
16
107
83
896
0.83
0.48
4.6
3.9
5.96
5.84
mmol/l
0.30
68
834
24
193
1.29
0.47
16.5
17.3
25.13
24.59
mmol/l
0.32
24
193
7
50
1.42
0.45
2.1
2.2
—
—
—
0
0
5
31
1.63
0.43
1.4
2.1
—
—
—
0
0
11
79
1.42
0.42
1.4
1.8
—
—
—
0
0
5
33
1.53
0.41
1.4
2.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
17
0.00
0.41
0.0
1.2
—
92.12
—
0
17
0
17
0.00
0.41
0.0
7.4
—
—
—
0
0
0
17
0.00
0.41
0.0
7.4
—
—
—
0
0
0
19
0.00
0.39
0.0
3.1
—
0.00
—
0
19
30
255
1.22
0.38
4.5
4.3
14.76
66.04
mg/mmol
0.43
23
195
10
72
1.42
0.38
1.4
1.2
—
—
—
0
0
5
79
0.62
0.36
5.6
7.3
92.40
87.92
%
—
5
79
104
991
1.17
0.34
3.8
3.5
—
—
—
0
0
29
250
1.20
0.33
3.9
3.0
1.02
1.02
kg/l
0.12
19
162
35
390
0.87
0.27
2.5
1.9
—
—
—
0
0
95
992
0.88
0.27
5.5
4.5
2.71
2.70
mmol/l
0.04
87
943
89
933
0.88
0.27
4.2
3.6
1.42
1.30
mmol/l
0.93
82
886
9
75
1.21
0.25
4.3
2.3
5.84
7.16
ug/l
—
9
69
53
490
1.13
0.25
13.7
12.4
1.24
1.22
mmol/l
1.31
53
466
24
209
1.18
0.25
1.7
3.8
0.79
1.93
mg/l
1.58
18
166
5
38
1.33
0.23
1.0
1.1
—
—
—
0
0
5
38
1.33
0.23
8.8
11.2
—
741.71
—
0
7
5
39
1.29
0.23
1.0
1.1
—
—
—
0
0
8
104
0.76
0.22
1.1
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
10.63
—
0
11
0
11
0.00
0.21
0.0
2.3
—
—
—
0
0
0
11
0.00
0.21
0.0
2.3
—
—
—
0
0
0
11
0.00
0.21
0.0
5.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
—
—
0
0
0
12
0.00
0.21
0.0
4.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
3.6
—
1206.08
—
0
13
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
120
1170
1.14
0.20
17.5
13.9
26.45
25.09
mg/l
0.15
88
879
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
6
49
1.23
0.20
2.2
2.2
—
—
—
0
0
95
983
0.90
0.19
4.9
4.1
1.28
1.29
mmol/l
0.15
86
935
8
72
1.12
0.16
1.3
1.9
—
—
—
0
0
24
219
1.11
0.13
5.0
5.1
1181.61
1034.52
ng/l
0.14
18
184
26
241
1.10
0.11
2.8
2.3
—
—
—
0
0
45
428
1.07
0.11
5.2
4.7
1.80
2.46
ug/l
0.35
40
387
5
43
1.17
0.10
4.6
3.5
570.40
719.16
ug/l
—
5
43
24
223
1.09
0.10
2.8
2.3
—
—
—
0
0
5
46
1.09
0.09
9.6
5.3
23.60
23.94
mmol/l
—
5
46
26
243
1.09
0.09
3.8
3.6
—
—
—
0
0
33
312
1.07
0.09
4.4
3.5
19.31
23.71
ng/l
0.45
21
199
7
64
1.10
0.08
1.7
1.5
—
—
—
0
0
132
1332
0.91
0.07
22.8
20.8
4.84
4.78
e12/l
0.58
126
1289
8
94
0.84
0.07
1.4
1.6
—
—
—
0
0
132
1330
0.92
0.05
22.8
20.9
251.17
250.18
e9/l
0.06
127
1288
37
382
0.96
0.04
1.6
1.7
8.43
2.27
u/ml
—
9
87
98
991
0.97
0.03
4.9
4.2
4.44
4.42
mmol/l
0.10
90
949
12
128
0.93
0.02
2.2
1.9
—
—
—
0
0
14
132
1.07
0.02
2.2
2.0
—
—
—
0
0
17
166
1.03
0.00
2.6
2.1
—
—
—
0
0
34
336
1.02
0.00
4.2
4.2
19.31
21.91
%
0.43
16
143
26
255
1.02
0.00
2.8
2.8
0.75
0.77
ug/l
0.04
16
143
90
904
0.99
0.00
17.8
12.2
92.49
94.56
ml/min/173m2
0.29
77
790
0
5
0.00
0.00
0.0
1.0
—
96.60
—
0
5
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
2.74
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
148.71
—
0
7
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
37.40
—
0
5
0
5
0.00
0.00
0.0
1.4
—
53.00
—
0
5
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
481.50
—
0
8
0
7
0.00
0.00
0.0
4.4
—
221.13
—
0
7
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
(3002348) Coagulation factor XII activity actual/normal in Platelet poor plasma by Coagulation assay
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
16.75
—
0
8
0
8
0.00
0.00
0.0
1.4
—
98.88
—
0
8
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
27.30
—
0
5
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
57.14
—
0
7
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
25.82
—
0
9
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
6
0.00
-0.00
0.0
1.0
—
82.50
—
0
6
5
55
0.91
-0.00
1.8
1.4
266.20
341.57
mu/l
—
5
55
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
10.83
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
76
0.92
-0.00
2.6
2.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
1.79
—
0
6
8
81
0.99
-0.00
2.3
2.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
49
1.02
-0.00
2.0
1.9
—
—
—
0
0
8
82
0.97
-0.00
12.6
8.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥This endpoint is excluded (different definition than used in FinnGen).
Relationships between endpoints
↥Index endpoint: Q17_HYPOSPADIAS – Hypospadias
GWS hits: -
This endpoint is excluded (different definition than used in FinnGen).