No definition available.
Congenital malformations of spine and bony thorax
DOID EFO Endpoint Browser PheWeb
Q17_CONGEN_MALFO_SPINE_BONY_THORAX
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
233 |
4. Check minimum number of eventsNone |
233 |
5. Include endpointsNone |
233 |
6. Filter based on genotype QC (FinnGen only) |
212 |
Control definitions (FinnGen only)
- Control exclude
- Q17_CONGEN_MALFO_DEFORMAT_MUSCULOS_SYSTEM
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- Q6[5-9]|Q7
- Name in latin
- Malformationes congenitae columnae vertebralis et ossium thoracis
Similar endpoints
↥List of similar endpoints to
Congenital malformations of spine and bony thorax
based on the number of shared cases.
Similar with more cases:
- Congenital malformations and deformations of the musculoskeletal system
- Congenital malformations and deformations of the musculoskeletal system, including avohilmo
- Vertebral, anorectal, cardiavascular, thracheoesophagial, renal and limb anomaly
- Vertebral, anorectal, cardiavascular, thracheoesophagial, renal and limb anomaly, including avohilmo
- Congenital malformations, deformations and chromosomal abnormalities
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2337 | 1195 | 1137 |
| Only index persons | 2038 | 1078 | 960 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 14.46 | 15.32 | 13.42 |
| Only index persons | 15.67 | 16.60 | 14.63 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 212 | 135 | 77 |
| Unadjusted period prevalence (%) | 0.04 | 0.05 | 0.04 |
| Median age at first event (years) | 27.05 | 31.16 | 19.83 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 222
- Matched controls
- 2220
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
38.4
82.2
53
18
Q76.30
ICD-10 Finland
Hemivertebra fusion or failure of segmentation with scoliosis
+∞
63.7
58
*
Q76.48
ICD-10 Finland
Congenital anomalies of other vertebrae, not associated with scoliosis
+∞
45.4
42
*
Q76.38
ICD-10 Finland
Congenital scoliosis due to other specified congenital bony malformation
+∞
33.2
31
*
Q76.1
ICD-10 Finland
Klippel-Feil syndrome
+∞
29.9
28
*
Q76.9
ICD-10 Finland
Congenital malformation of bony thorax, unspecified
+∞
26.6
25
*
N03AX12
ATC
[U] gabapentin; oral
4.8
21.2
59
157
Q76.3
ICD-10 Finland
Congenital scoliosis due to congenital bony malformation
+∞
19.0
18
*
Z31.5
ICD-10 Finland
Genetic counselling
5.2
18.2
42
95
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
5.5
18.1
39
83
N06AX21
ATC
duloxetine; oral
4.5
17.1
49
132
M41.1
ICD-10 Finland
Juvenile idiopathic scoliosis
19.9
16.9
25
14
Q79.6
ICD-10 Finland
Ehlers-Danlos syndrome
+∞
16.9
16
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
5.1
16.7
39
89
WX408
NOMESCO Finland
General anesthesy, balanced
3.3
16.0
89
375
NA1AD
NOMESCO Finland
Cervical spine CT examination
7.9
16.0
23
32
ZXE20
NOMESCO Finland
More than three and less than five hours
4.2
15.5
48
137
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.9
15.1
54
171
TPH07
NOMESCO Finland
Cathetrisation of artery
4.6
14.8
39
98
N02BF01
ATC
gabapentin; oral
4.5
14.7
40
103
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
5.0
14.6
34
77
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
5.7
14.0
28
55
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
5.5
14.0
29
59
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
11.6
13.6
25
24
N02AX02
ATC
tramadol; systemic, rectal
2.9
13.6
101
493
UKC02
NOMESCO Finland
Cystoscopy
4.3
13.5
39
105
Z3226
NOMESCO Finland
Physiotherapist
3.2
13.1
69
277
NAG53
NOMESCO Finland
Posterior or lateral fusion of thoracic spine with fixation, more than 3 vertebraea
74.2
12.7
14
*
Q76.68
ICD-10 Finland
Other congenital malformations of ribs
+∞
12.6
12
*
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
4.0
12.5
40
116
ZXD10
NOMESCO Finland
Scheduled procedure
2.8
12.3
103
530
M41.9
ICD-10 Finland
Scoliosis, unspecified
15.8
12.0
19
13
ZXE30
NOMESCO Finland
More than five and less than seven hours
5.4
12.0
25
51
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
13.6
11.9
20
16
Q76.0
ICD-10 Finland
Spina bifida occulta
+∞
11.6
11
*
N03AX16
ATC
[U] pregabalin
3.1
11.5
58
226
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.3
11.0
47
165
R4120
NOMESCO Finland
Occupational therapy
4.4
10.7
29
74
N03AE01
ATC
clonazepam; systemic
5.3
10.5
22
45
M41.5
ICD-10 Finland
Other secondary scoliosis
+∞
10.5
10
*
Q87.26
ICD-10 Finland
VATER association
+∞
10.5
10
*
L82
ICPC
Congenital anomaly musculoskeletal
+∞
10.5
10
*
R4110
NOMESCO Finland
Physiotherapy
2.6
10.1
81
400
M54.2
ICD-10 Finland
Cervicalgia
3.9
10.1
32
92
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
9.9
104
582
N06AA09
ATC
amitriptyline; systemic
4.3
9.9
27
69
ZXE10
NOMESCO Finland
More than one and less than three hours
2.5
9.8
91
482
TPH04
NOMESCO Finland
Cathetrisation of vein
2.8
9.2
58
252
WX882
NOMESCO Finland
High dependency care
4.5
9.2
23
55
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
13.3
9.0
15
12
M35.7
ICD-10 Finland
Hypermobility syndrome
13.3
9.0
15
12
J45.9
ICD-10 Finland
Asthma, unspecified
2.7
8.7
55
239
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.8
8.5
49
203
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.7
8.5
57
256
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
4.2
8.4
23
59
Q76.42
ICD-10 Finland
Congenital anomalies of sacral vetebrae
+∞
8.4
8
*
Q76.2
ICD-10 Finland
Congenital spondylolisthesis
+∞
8.4
8
*
ZXA05
NOMESCO Finland
Left side
2.7
8.3
53
231
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.5
8.3
30
94
M54.6
ICD-10 Finland
Pain in thoracic spine
3.6
8.3
29
89
Z01.8
ICD-10 Finland
Other specified special examinations
2.5
8.1
64
310
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.5
8.0
62
297
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.8
8.0
25
71
UGC12
NOMESCO Finland
Flexible bronchoscopy
4.5
7.9
20
48
Q76.5
ICD-10 Finland
Cervical rib
46.6
7.8
9
*
Z3229
NOMESCO Finland
Other healthcare associate professional
3.2
7.7
33
115
N03AX09
ATC
lamotrigine; oral
4.0
7.7
23
63
A03FA02
ATC
cisapride; oral, rectal
4.5
7.6
19
45
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
26.0
7.6
10
*
UJF32
NOMESCO Finland
Coloscopy
2.6
7.5
53
242
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
3.6
7.5
26
79
WX892
NOMESCO Finland
Monitored bed care
3.7
7.5
25
74
ZXD05
NOMESCO Finland
Urgent procedure
2.3
7.5
81
449
M79.0
ICD-10 Finland
Rheumatism, unspecified
7.3
7.5
17
25
ZX120
NOMESCO Finland
Intravenous
3.3
7.4
30
101
Q76.40
ICD-10 Finland
Congenital absence of vertebrae without scoliosis
+∞
7.3
7
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.4
7.3
28
91
M41.2
ICD-10 Finland
Other idiopathic scoliosis
16.4
7.3
11
7
Q25.0
ICD-10 Finland
Patent ductus arteriosus
16.4
7.3
11
7
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.7
7.2
44
187
M41.8
ICD-10 Finland
Other forms of scoliosis
20.8
7.2
10
5
XKC03
NOMESCO Finland
Water cystometry
7.4
7.1
16
23
J45.1
ICD-10 Finland
Nonallergic asthma
3.1
7.1
31
109
M54.5
ICD-10 Finland
Low back pain
2.2
7.1
91
537
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.7
7.1
44
188
B02AA02
ATC
tranexamic acid; systemic
2.8
7.1
40
163
WX725
NOMESCO Finland
Noninvasive ventilation
4.6
7.1
17
39
A28
ICPC
Limited function/disability NOS
2.9
7.0
35
133
N04BC05
ATC
pramipexole; oral
4.0
7.0
20
53
N06AX16
ATC
venlafaxine; oral
2.7
6.9
43
184
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
17.4
6.8
10
6
NAG63
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, more than 3 vertebraea
41.4
6.8
8
*
G44.2
ICD-10 Finland
Tension-type headache
2.7
6.8
41
173
Q21.00
ICD-10 Finland
Multiple ventricular septal defect
12.8
6.7
11
9
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
9.1
6.6
13
15
R03AC13
ATC
formoterol; inhalant
6.5
6.6
16
26
M01AH01
ATC
celecoxib; oral
2.8
6.5
34
133
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.3
6.4
61
318
NAT20
NOMESCO Finland
Reinsertion and tuning of internal fixation device
+∞
6.3
6
*
Q76.78
ICD-10 Finland
Other specified congenital malformation of sternum
+∞
6.3
6
*
Q66.0
ICD-10 Finland
Talipes equinovarus
+∞
6.3
6
*
NAK30
NOMESCO Finland
Osteotomy of spine
+∞
6.3
6
*
Q87.88
ICD-10 Finland
Other specified congenital malformation syndromes, not elsewhere classified
27.5
6.3
8
*
UDQ12
NOMESCO Finland
Flexible laryngoscopy
4.3
6.2
16
39
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
9.0
6.1
12
14
WX402
NOMESCO Finland
General anaesthesia
2.2
6.1
62
331
Z3231
NOMESCO Finland
Registered nurse
2.1
6.1
80
472
ZXA00
NOMESCO Finland
Right side
2.3
6.1
51
251
N06CA01
ATC
amitriptyline and psycholeptics; systemic
3.2
6.0
24
80
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
4.2
6.0
16
40
XX9AW
NOMESCO Finland
Production of copy from X-ray picture
4.2
6.0
16
40
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
82
464
2.22
7.14
2.7
2.3
145.33
161.32
u/l
0.21
82
443
78
439
2.20
6.83
2.8
2.6
—
—
—
0
0
37
156
2.65
6.12
10.9
13.4
14.98
13.61
kpa
0.49
37
150
37
156
2.65
6.12
10.9
13.4
5.43
5.29
kpa
0.48
37
150
67
398
1.98
4.85
4.2
2.8
1.65
0.98
mg/l
0.56
53
303
119
855
1.84
4.78
3.9
3.2
73.13
72.05
nmol/l
0.16
114
795
28
118
2.57
4.62
2.1
1.6
—
—
—
0
0
48
262
2.06
4.36
1.8
1.6
133333774.71
51092169.73
pmol/l
0.25
48
229
117
859
1.77
4.18
17.2
9.8
1.21
1.22
mmol/l
0.52
110
761
77
500
1.83
4.17
3.2
2.8
2.98
2.60
mg/l
0.70
69
441
41
215
2.11
4.12
18.9
9.4
105.73
104.48
mmol/l
1.33
41
215
35
174
2.20
4.02
13.8
7.8
2.20
1.28
mmol/l
1.00
30
132
135
1053
1.72
3.72
11.5
6.6
6.48
6.38
mmol/l
0.17
128
961
36
194
2.02
3.36
2.4
1.7
—
—
—
0
0
20
84
2.52
3.34
14.6
12.0
25.79
25.54
mmol/l
0.09
20
79
26
124
2.24
3.30
1.7
2.1
7.77
8.89
u/l
0.18
20
90
36
197
1.99
3.22
2.4
1.6
—
—
—
0
0
35
190
2.00
3.20
19.6
8.5
24.33
23.78
mmol/l
0.82
35
190
81
571
1.66
3.14
3.1
2.9
2.35
2.36
mmol/l
0.28
76
524
10
25
4.14
3.12
1.7
5.4
—
—
—
0
0
87
626
1.64
3.10
7.9
4.0
—
—
—
0
0
110
843
1.60
3.01
3.6
3.0
—
—
estimate
—
0
0
36
203
1.92
2.96
1.5
1.6
1166.40
1143.79
nmol/l
0.05
30
156
14
52
2.81
2.95
3.7
2.4
0.86
3.21
index
—
7
28
18
77
2.46
2.90
3.1
1.5
—
—
—
0
0
63
427
1.66
2.80
2.0
1.5
19.39
21.22
nmol/l
0.36
58
373
13
48
2.81
2.77
2.8
1.6
—
—
—
0
0
5
6
8.49
2.76
4.6
3.0
84.60
104.50
%
—
5
6
142
1173
1.58
2.71
11.2
11.3
4.16
3.90
e9/l
0.62
133
1017
126
1020
1.54
2.58
5.0
3.8
0.00
0.00
estimate
-0.00
23
194
155
1316
1.59
2.55
10.1
7.5
86.37
88.32
u/l
0.17
150
1240
18
82
2.30
2.55
2.5
1.6
—
—
—
0
0
45
285
1.73
2.55
4.1
3.3
1482.48
426.08
ng/l
0.82
27
166
125
1015
1.53
2.49
5.1
3.7
0.00
0.00
estimate
-0.00
23
201
11
38
2.99
2.45
2.3
1.3
—
—
—
0
0
11
38
2.99
2.45
2.3
1.3
—
—
—
0
0
124
1008
1.52
2.44
5.1
3.7
0.00
0.00
estimate
-0.00
22
203
88
667
1.53
2.39
2.4
1.9
95.75
94.32
pmol/l
0.11
55
338
5
8
6.36
2.38
1.6
1.0
90.60
83.88
%
—
5
8
50
332
1.65
2.38
6.6
3.3
2.37
0.69
e6/l
0.97
30
181
72
525
1.55
2.32
7.5
3.7
0.46
0.23
e6/l
0.26
54
376
72
527
1.54
2.28
4.7
3.7
0.00
0.01
estimate
0.50
20
194
66
474
1.56
2.27
4.6
3.3
1.02
1.02
kg/l
0.52
41
313
26
145
1.90
2.22
6.7
6.4
49.67
62.71
ng/l
1.02
26
135
8
24
3.42
2.20
1.3
1.1
—
—
—
0
0
95
744
1.48
2.16
4.3
3.4
0.00
0.01
estimate
0.50
19
172
41
265
1.67
2.15
2.5
1.8
—
—
—
0
0
47
315
1.62
2.15
6.6
3.6
3.13
2.61
e6/l
0.19
27
166
8
25
3.28
2.11
1.3
1.1
—
—
—
0
0
15
69
2.26
2.10
17.3
11.3
1.93
1.54
%
0.75
15
64
5
10
5.09
2.08
4.0
2.5
406.60
1138.10
u/ml
—
5
10
5
10
5.09
2.08
3.0
1.4
4.70
6.21
u/l
—
5
10
5
13
3.91
1.72
1.0
1.0
880.40
1606.62
miu/ml
—
5
13
13
242
0.51
1.59
1.5
2.0
3.43
3.39
ratio
—
7
190
8
33
2.48
1.55
1.4
1.2
—
—
—
0
0
5
15
3.38
1.53
1.4
1.1
—
—
—
0
0
7
27
2.64
1.52
1.1
1.1
—
—
—
0
0
6
22
2.77
1.44
1.0
1.1
—
—
—
0
0
16
89
1.86
1.41
34.2
7.3
0.73
0.64
%
0.38
16
89
11
53
2.13
1.41
1.2
3.6
1.18
16.29
e6/l
0.59
11
38
11
54
2.09
1.35
1.4
3.6
198.09
343.74
e6/l
0.29
11
39
206
1955
1.75
1.34
23.7
15.1
65.00
69.23
umol/l
2.79
206
1930
5
18
2.82
1.29
1.0
1.1
—
—
—
0
0
46
344
1.43
1.27
1.3
1.3
5.24
6.41
u/ml
0.10
21
121
49
371
1.41
1.27
1.4
1.3
35.06
30.82
iu/ml
0.09
12
91
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
5
19
2.67
1.22
1.4
1.1
—
—
—
0
0
10
50
2.05
1.18
1.3
1.4
—
—
—
0
0
20
130
1.59
1.07
1.2
1.3
—
—
—
0
0
22
147
1.55
1.05
3.7
6.3
—
—
—
0
0
0
30
0.00
0.98
0.0
2.9
—
15.35
—
0
15
6
117
0.50
0.97
2.2
1.7
—
—
—
0
0
171
1592
1.32
0.97
16.1
11.5
96.36
92.38
ml/min/173m2
1.59
158
1417
17
111
1.58
0.90
1.8
3.5
83.22
74.67
ml/min/173m2
—
9
46
26
187
1.44
0.90
1.3
1.3
36.80
144.28
u/ml
—
6
73
10
56
1.82
0.89
1.2
1.4
—
—
—
0
0
6
30
2.03
0.87
1.0
1.3
—
—
—
0
0
14
88
1.63
0.86
2.9
2.4
49.57
39.54
u/l
1.07
14
80
80
690
1.25
0.82
1.3
1.7
0.52
1.80
u/ml
2.13
21
161
6
32
1.90
0.82
1.2
1.5
—
—
—
0
0
13
83
1.60
0.77
6.8
5.9
46.75
50.57
%
0.25
13
83
9
53
1.73
0.76
1.2
1.2
—
—
—
0
0
63
534
1.25
0.75
4.7
3.4
24.13
29.25
ng/l
0.21
39
292
28
212
1.37
0.75
3.3
4.0
19.92
21.72
%
0.28
12
85
6
109
0.54
0.74
1.7
2.2
—
—
—
0
0
10
60
1.70
0.73
2.3
1.6
0.20
0.30
nmol/l
—
10
49
9
56
1.63
0.73
1.4
2.0
—
—
—
0
0
7
40
1.77
0.72
1.6
3.1
—
—
—
0
0
178
1690
1.27
0.69
4.6
4.8
2.63
2.77
mmol/l
1.44
173
1600
5
93
0.53
0.68
1.0
1.2
0.76
0.93
g/l
—
5
93
5
30
1.68
0.62
2.0
1.2
—
—
—
0
0
5
30
1.68
0.62
1.6
1.6
—
—
—
0
0
199
1924
1.33
0.60
23.7
13.5
22.64
21.32
mg/l
0.26
170
1501
5
90
0.55
0.57
1.0
1.1
1.66
1.56
g/l
—
5
90
37
305
1.26
0.56
1.9
1.9
1.64
1.41
%
0.97
32
272
50
428
1.22
0.55
4.3
4.1
4.64
48.16
mg/mmol
0.60
35
293
6
38
1.59
0.54
1.2
2.4
0.00
0.00
g/l
—
6
38
41
483
0.81
0.53
2.4
2.3
—
—
—
0
0
6
39
1.55
0.53
1.2
2.4
0.00
0.00
g/l
—
6
39
11
75
1.49
0.51
1.0
1.1
—
12.22
—
0
10
175
1676
1.21
0.51
4.1
4.4
1.45
1.47
mmol/l
0.24
168
1577
17
127
1.37
0.51
4.0
3.0
—
—
—
0
0
10
68
1.49
0.48
1.1
1.1
—
—
—
0
0
7
48
1.47
0.47
1.3
1.5
—
—
—
0
0
165
1578
1.18
0.46
3.6
3.8
1.22
1.23
mmol/l
0.14
160
1478
181
1745
1.20
0.45
26.0
17.2
333.45
333.90
g/l
0.27
181
1735
18
139
1.32
0.45
1.3
1.4
—
—
—
0
0
39
453
0.83
0.44
2.4
2.1
—
—
—
0
0
5
31
1.63
0.43
1.2
1.6
—
—
—
0
0
10
70
1.45
0.42
1.2
1.1
—
—
—
0
0
8
59
1.37
0.41
1.5
1.8
—
—
—
0
0
8
59
1.37
0.41
3.1
2.0
64.97
1.41
ug/l
—
8
54
0
15
0.00
0.41
0.0
2.0
—
0.46
—
0
5
0
16
0.00
0.41
0.0
3.9
—
—
—
0
0
0
16
0.00
0.41
0.0
3.9
—
—
—
0
0
0
18
0.00
0.40
0.0
4.4
—
99.37
—
0
18
6
41
1.48
0.36
1.3
2.6
—
—
—
0
0
6
42
1.44
0.36
1.2
2.3
0.00
0.17
g/l
—
6
42
169
1634
1.14
0.34
4.6
4.0
5.66
5.68
mmol/l
0.07
164
1509
21
249
0.83
0.31
2.0
2.0
—
—
—
0
0
75
695
1.12
0.31
1.8
2.0
—
—
—
0
0
8
63
1.28
0.28
1.6
1.8
—
—
—
0
0
13
159
0.81
0.25
1.4
1.5
—
—
—
0
0
20
170
1.19
0.25
2.6
2.6
6776.64
4896.78
u/l
0.11
14
70
19
162
1.19
0.23
2.8
2.5
0.50
0.76
ug/l
1.90
13
83
7
95
0.73
0.22
1.1
1.4
—
—
—
0
0
5
40
1.26
0.22
1.2
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
38.66
—
0
5
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
4.6
—
0.60
—
0
10
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
1.90
—
0
10
0
12
0.00
0.21
0.0
1.1
—
2.00
—
0
5
0
13
0.00
0.21
0.0
2.0
—
4.24
—
0
13
6
48
1.26
0.20
3.7
11.0
—
3715.71
—
0
7
42
386
1.11
0.20
2.2
3.9
301.86
323.32
umol/l
0.77
37
349
158
1618
0.92
0.19
3.6
3.8
—
—
—
0
0
6
51
1.18
0.19
1.7
1.5
—
—
—
0
0
61
573
1.09
0.19
2.9
3.1
0.00
0.00
estimate
-0.00
20
160
7
58
1.21
0.18
1.3
1.3
—
—
—
0
0
7
59
1.19
0.18
1.1
1.3
—
53.30
—
0
5
20
176
1.15
0.18
1.0
1.1
—
—
—
0
0
5
66
0.75
0.17
1.4
1.3
—
—
—
0
0
8
71
1.13
0.16
1.1
1.3
—
7.81
—
0
14
198
1955
1.12
0.16
14.0
11.0
24.91
26.33
u/l
0.68
198
1901
9
78
1.16
0.15
2.2
1.7
—
—
—
0
0
14
123
1.15
0.13
1.8
1.6
—
—
—
0
0
11
127
0.86
0.12
2.1
1.6
0.24
0.27
mg/l
—
5
51
37
348
1.08
0.11
2.1
1.6
—
—
—
0
0
28
300
0.92
0.10
2.0
2.2
—
—
—
0
0
11
124
0.88
0.09
1.4
1.6
—
—
—
0
0
8
92
0.86
0.07
1.8
1.4
—
—
—
0
0
8
93
0.86
0.07
1.5
1.9
—
—
—
0
0
9
102
0.88
0.06
1.9
1.8
—
—
—
0
0
10
91
1.10
0.04
1.4
1.5
57.32
51.06
ug/l
—
10
91
212
2122
0.98
0.00
32.7
20.3
4.53
4.55
e12/l
0.27
212
2081
212
2122
0.98
0.00
34.1
21.0
40.20
40.45
%
0.33
212
2103
11
112
0.98
0.00
1.4
1.3
—
—
—
0
0
212
2121
0.99
0.00
32.5
20.3
89.58
89.34
fl
0.29
212
2103
212
2123
0.97
0.00
33.0
20.6
134.62
135.44
g/l
0.38
212
2105
5
55
0.91
0.00
3.2
2.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.3
—
10.61
—
0
9
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
5
59
0.84
-0.00
2.6
2.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
50
1.00
-0.00
1.2
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
100.53
—
0
7
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
25.14
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
212
2120
1.00
-0.00
32.7
20.4
261.36
261.13
e9/l
0.02
212
2084
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.3
—
4.60
—
0
9
5
54
0.92
-0.00
1.2
1.7
0.89
0.62
nmol/l
—
5
47
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
11.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_CONGEN_MALFO_SPINE_BONY_THORAX and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_CONGEN_MALFO_SPINE_BONY_THORAX | 1.972 [1.38, 2.82] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.883 |
During the follow-up period (1.1.1998 — 31.12.2019), 54 out of 1044 females with Q17_CONGEN_MALFO_SPINE_BONY_THORAX died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have Q17_CONGEN_MALFO_SPINE_BONY_THORAX.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.158% | No data |
| 5 | 1.134% | No data |
| 10 | 2.98% | No data |
| 15 | 6.321% | No data |
| 20 | 11.558% | No data |
Relationships between endpoints
↥Index endpoint: Q17_CONGEN_MALFO_SPINE_BONY_THORAX – Congenital malformations of spine and bony thorax
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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