Phlebitis and thrombophlebitis of other deep vessels of lower extremities, drug-induced

PHLEBI_THROMBOP_OTHER_DEEP_VESSE_LOWER_EXTREMITI

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ATC codes for adverse effects of Drugs ANY
  • Hospital discharge: ICD-10 I80.29#

1 out of 7 registries used, show all original rules.

125

4. Check minimum number of events

None

125

5. Include endpoints

None

125

6. Filter based on genotype QC (FinnGen only)

112

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (not available in FinRegistry).

-FinnGen-

Key figures

All Female Male
Number of individuals 112 63 49
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 50.92 48.07 54.58

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
115
Matched controls
1150
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I80.29
ICD-10 Finland
Phlebitis and thrombophlebitis of other deep vessels of lower extremities
+∞
142.4
115
20
B01AA03
ATC
warfarin; systemic
18.2
53.0
87
168
I80.3
ICD-10 Finland
Phlebitis and thrombophlebitis of lower extremities, unspecified
16.7
33.8
32
26
B01AB04
ATC
dalteparin; parenteral
14.8
14.4
24
20
B01AB05
ATC
enoxaparin; parenteral
4.4
14.2
66
268
379
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the long-term prevention of recurrent deep veinthrombosis and pulmonary embolism
13.1
9.9
17
15
D68.8
ICD-10 Finland
Other specified coagulation defects
24.2
6.8
9
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
27
71
4.66
9.91
5.4
3.9
—
—
—
0
0
11
20
5.96
4.41
8.9
3.4
—
—
—
0
0
11
27
4.39
3.50
10.2
4.5
7.43
7.42
ph
0.11
11
27
0
86
0.00
3.49
0.0
3.8
—
7.37
—
0
54
19
78
2.72
3.43
7.5
4.5
1.23
1.22
mmol/l
0.20
14
69
10
23
4.66
3.40
8.9
3.6
4.86
4.97
kpa
—
10
23
10
23
4.66
3.40
8.9
3.6
8.36
8.82
kpa
—
10
23
37
222
1.98
2.77
6.4
5.5
—
—
—
0
0
58
405
1.87
2.76
4.6
4.0
0.00
0.00
estimate
-0.00
25
97
9
24
3.98
2.73
6.3
2.2
128.11
127.75
g/l
—
9
16
45
292
1.89
2.67
4.4
3.0
0.36
0.38
e6/l
0.04
40
205
7
16
4.58
2.51
2.3
2.1
6.39
5.53
e9/l
—
7
16
6
12
5.21
2.43
4.5
2.7
88.87
91.34
%
—
6
12
8
22
3.83
2.41
2.8
2.0
63.00
63.29
%
—
8
22
70
535
1.79
2.34
4.9
4.0
0.00
14.00
estimate
0.50
28
116
70
538
1.77
2.27
5.0
4.1
0.00
0.00
estimate
-0.00
24
106
46
314
1.77
2.25
5.4
4.1
0.00
0.00
estimate
-0.00
26
102
69
531
1.75
2.20
4.9
3.9
0.00
0.00
estimate
-0.00
28
114
35
228
1.77
1.97
2.4
1.8
1.97
1.26
mg/l
0.60
30
197
42
289
1.71
1.95
4.5
3.4
0.00
0.00
estimate
-0.00
25
86
20
113
1.93
1.74
2.0
1.6
—
—
—
0
0
40
282
1.64
1.66
4.5
2.9
—
—
estimate
—
0
0
5
15
3.43
1.54
9.2
5.6
—
—
—
0
0
58
454
1.56
1.54
8.6
4.8
33.94
35.25
g/l
0.68
49
434
45
335
1.56
1.47
3.8
3.5
—
—
—
0
0
46
347
1.54
1.41
4.4
3.2
23.26
216.07
e6/l
0.51
40
262
50
385
1.53
1.39
5.2
3.8
91.28
60.04
e6/l
0.17
42
272
44
331
1.53
1.36
11.0
4.1
7.40
7.39
ph
0.40
32
237
16
92
1.86
1.33
5.9
3.9
0.40
0.79
%
—
5
34
13
70
1.97
1.30
10.1
8.8
24.97
25.00
mmol/l
0.01
13
70
15
86
1.86
1.26
1.7
1.6
—
—
—
0
0
53
421
1.48
1.24
3.9
3.5
6.25
6.25
ph
0.01
32
235
5
19
2.70
1.23
7.0
3.7
15.46
12.29
pmol/l
—
5
19
30
214
1.54
1.16
2.4
1.7
611.40
488.82
pmol/l
0.50
20
182
23
154
1.62
1.15
1.4
1.3
1.12
12.83
u/ml
1.87
13
57
10
52
2.01
1.10
1.1
1.2
—
—
—
0
0
15
91
1.75
1.07
6.3
3.8
0.00
0.81
%
—
5
34
40
312
1.43
0.99
2.9
3.2
—
—
—
0
0
0
30
0.00
0.99
0.0
1.2
—
—
—
0
0
54
446
1.40
0.97
23.3
12.6
0.00
0.00
e9/l
0.50
45
359
9
155
0.55
0.97
8.0
7.6
103.00
103.79
mmol/l
—
9
155
52
427
1.40
0.96
5.2
4.1
35.87
41.10
ng/l
0.13
41
317
19
130
1.55
0.88
1.3
1.4
—
—
—
0
0
80
871
0.73
0.75
4.8
4.6
1.50
1.28
mmol/l
1.56
74
794
41
339
1.33
0.69
9.6
5.6
—
—
—
0
0
6
103
0.56
0.65
14.5
7.8
1.25
1.33
mmol/l
—
6
103
24
184
1.38
0.65
2.0
1.8
1362.73
1271.10
nmol/l
0.28
15
141
5
29
1.76
0.64
1.0
1.1
—
—
—
0
0
85
909
0.75
0.61
5.8
5.5
4.50
4.55
mmol/l
0.18
80
845
25
313
0.74
0.61
2.4
2.4
—
—
—
0
0
12
81
1.54
0.60
3.7
2.0
—
—
—
0
0
6
37
1.66
0.56
3.0
1.2
—
—
—
0
0
6
37
1.66
0.56
2.3
1.7
—
—
—
0
0
17
127
1.40
0.53
1.4
1.3
—
—
—
0
0
35
296
1.26
0.49
6.3
4.6
—
—
—
0
0
8
58
1.41
0.42
1.1
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
17
0.00
0.41
0.0
1.3
—
—
—
0
0
88
924
0.80
0.41
6.6
6.4
2.58
2.62
mmol/l
0.15
83
856
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
8
113
0.69
0.39
4.6
5.1
2.94
47.88
ug/l
—
8
95
86
904
0.81
0.39
5.5
5.5
1.41
1.49
mmol/l
0.98
81
831
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
13
100
1.34
0.35
1.6
1.3
—
—
—
0
0
17
137
1.28
0.34
12.4
5.2
0.97
1.05
mmol/l
0.56
17
130
60
553
1.18
0.34
15.0
11.0
4.48
3.96
e9/l
0.86
52
485
95
984
0.80
0.32
40.0
27.8
41.05
40.15
%
1.29
95
975
95
984
0.80
0.32
39.4
27.1
91.48
91.86
fl
0.27
95
977
95
984
0.80
0.32
39.3
27.0
30.21
30.50
pg
0.73
95
977
95
984
0.80
0.32
40.1
27.3
135.21
133.88
g/l
0.40
95
976
12
93
1.32
0.31
9.2
2.3
9.47
10.23
g/l
0.43
12
82
7
57
1.24
0.29
3.3
4.3
36.97
36.96
°c
—
7
57
90
933
0.84
0.27
25.2
16.2
—
—
—
0
0
21
179
1.21
0.27
1.5
1.3
12.78
35.72
iu/ml
—
9
61
12
96
1.28
0.25
4.1
2.1
68.16
66.47
g/l
0.34
12
87
9
75
1.22
0.25
2.0
1.5
1.01
1.14
g/l
—
9
65
27
239
1.17
0.24
4.4
4.3
1.02
1.02
kg/l
0.05
17
154
55
514
1.13
0.23
9.6
5.9
0.63
0.60
e9/l
0.35
49
438
48
445
1.13
0.23
2.8
2.8
—
—
estimate
—
0
0
55
515
1.13
0.22
9.7
6.0
0.04
0.04
e9/l
0.25
49
438
94
911
1.17
0.22
29.4
18.0
18.53
22.21
mg/l
0.86
87
783
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
3.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
52642.00
—
0
5
0
12
0.00
0.21
0.0
2.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
0.20
—
0
7
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
16
137
1.20
0.20
3.1
3.6
5.72
4.22
e9/l
0.62
16
117
30
272
1.14
0.19
3.0
2.9
—
0.22
—
0
9
95
974
0.86
0.19
34.1
23.7
81.17
79.58
umol/l
0.17
95
965
49
520
0.90
0.18
14.0
7.5
1.21
1.21
mmol/l
0.32
34
456
55
520
1.11
0.18
9.6
6.0
1.80
1.98
e9/l
0.54
49
457
5
65
0.76
0.17
11.8
2.8
24.20
24.48
mmol/l
—
5
65
8
69
1.17
0.17
1.6
1.5
—
—
—
0
0
8
69
1.17
0.17
2.6
2.3
11.51
13.45
nmol/l
—
8
63
8
70
1.15
0.16
8.9
4.5
—
—
—
0
0
6
77
0.77
0.16
1.0
1.2
—
—
—
0
0
25
227
1.13
0.16
1.6
1.2
0.81
1.38
u/ml
0.47
11
65
39
365
1.10
0.15
5.3
3.9
16.53
9.02
mg/mmol
0.26
23
224
12
139
0.85
0.15
1.6
1.4
—
—
—
0
0
44
465
0.91
0.14
2.0
2.2
108.66
96.50
pmol/l
1.55
24
237
55
525
1.09
0.14
10.7
6.2
0.20
0.20
e9/l
0.08
48
456
11
94
1.19
0.13
3.1
2.7
0.19
0.21
g/l
0.35
11
86
9
108
0.82
0.13
7.2
3.2
2.26
1.76
mmol/l
—
9
91
23
210
1.12
0.13
4.7
3.7
194.26
227.87
ng/l
0.06
17
168
22
240
0.90
0.12
1.6
1.4
—
—
—
0
0
38
401
0.92
0.11
2.8
2.1
—
—
—
0
0
5
43
1.17
0.10
3.8
1.2
—
—
—
0
0
43
411
1.07
0.10
2.5
2.0
1.40
1.34
mmol/l
0.16
34
345
38
363
1.07
0.08
3.9
3.1
6.62
7.34
mmol/l
0.66
33
300
5
62
0.80
0.08
1.2
2.7
1.35
1.36
g/l
—
5
55
22
206
1.08
0.07
1.5
1.3
2.58
2.59
g/l
0.01
16
114
17
157
1.10
0.07
2.9
1.8
—
—
—
0
0
9
84
1.08
0.07
4.9
3.2
—
—
—
0
0
10
89
1.14
0.07
21.4
5.4
11.33
10.03
mmol/l
—
10
83
13
141
0.91
0.05
11.4
8.1
5.58
5.15
kpa
0.44
13
136
13
141
0.91
0.05
11.4
8.1
12.05
12.13
kpa
0.02
13
136
30
311
0.95
0.04
14.8
7.3
—
—
—
0
0
12
128
0.93
0.03
2.3
1.9
—
—
—
0
0
48
472
1.03
0.02
14.0
6.5
1.21
1.21
mmol/l
0.18
42
437
35
356
0.98
0.00
4.0
3.3
105.69
57.47
mg/l
0.27
22
231
47
464
1.02
0.00
9.1
6.2
58.46
57.48
%
0.23
47
443
12
116
1.04
0.00
2.1
1.5
—
—
—
0
0
10
99
1.01
0.00
1.6
1.6
—
—
—
0
0
15
145
1.04
0.00
1.5
1.3
—
—
—
0
0
95
954
0.98
0.00
31.2
21.4
3.97
4.00
mmol/l
0.43
95
942
95
951
0.99
0.00
30.8
21.3
139.98
139.69
mmol/l
0.55
95
938
0
5
0.00
0.00
0.0
3.0
—
6.10
—
0
5
0
8
0.00
0.00
0.0
4.0
—
3.11
—
0
8
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
12.6
—
933.40
—
0
5
0
8
0.00
0.00
0.0
9.6
—
8.71
—
0
8
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
7
76
0.92
-0.00
9.0
9.4
23.81
24.79
mmol/l
—
7
76
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
10.8
—
0.65
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.8
—
0.67
—
0
6
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
7
78
0.89
-0.00
13.4
8.1
26.79
24.94
mmol/l
—
7
73
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
10.7
—
16.79
—
0
7

Mortality – FinRegistry

This endpoint is excluded (not available in FinRegistry).

Relationships between endpoints

Index endpoint: PHLEBI_THROMBOP_OTHER_DEEP_VESSE_LOWER_EXTREMITI – Phlebitis and thrombophlebitis of other deep vessels of lower extremities, drug-induced

GWS hits: -

This endpoint is excluded (not available in FinRegistry).