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Fetus and newborn affected by maternal factors and by complications of pregnancy, labour and delivery

EFO Endpoint Browser PheWeb

P16_FET_NEWB_MATERN_FACTO_COMPLICATIO_PREGNAC_LABOUR_DELIV

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — P00-P04
  • Cause of death: ICD-10 — P00-P04

2 out of 7 registries used, show all original rules.

545

4. Check minimum number of events

None

545

5. Include endpoints

545

6. Filter based on genotype QC (FinnGen only)

462

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
P
Name in latin
Fetus et neonatus factoribus maternis atque complicationibus graviditatis, laborum et partus affectus

Similar endpoints

↥

List of similar endpoints to Fetus and newborn affected by maternal factors and by complications of pregnancy, labour and delivery based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 43198 19780 23410
Only index persons 16855 7854 9001
Unadjusted period prevalence (%)
Whole population 0.61 0.57 0.65
Only index persons 0.32 0.29 0.34
Median age at first event (years)
Whole population 0.01 0.00 0.00
Only index persons 0.00 0.00 0.00

-FinnGen-

Key figures

All Female Male
Number of individuals 462 251 211
Unadjusted period prevalence (%) 0.09 0.09 0.10
Median age at first event (years) 0.00 0.00 0.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
510
Matched controls
5039
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
P07.3
ICD-10 Finland
Other preterm infants
24.6
250.1
208
137
Z87.6
ICD-10 Finland
Personal history of certain conditions arising in the perinatal period
13.9
146.9
160
161
P01.5
ICD-10 Finland
Fetus and newborn affected by multiple pregnancy
+∞
112.3
104
*
P00.0
ICD-10 Finland
Fetus and newborn affected by maternal hypertensive disorders
+∞
107.8
100
*
P01.10
ICD-10 Finland
Fetus and newborn affected by premature rupture of membranes 1-7 days before delivery
+∞
100.0
93
*
P07.12
ICD-10 Finland
Other low birth weight 2000-2499 g
14.2
62.5
60
47
P59.0
ICD-10 Finland
Neonatal jaundice associated with preterm delivery
11.6
51.6
56
53
P07.11
ICD-10 Finland
Other low birth weight 1500-1999 g
18.8
51.4
42
24
P03.4
ICD-10 Finland
Fetus and newborn affected by caesarean delivery
+∞
45.3
43
*
P70.4
ICD-10 Finland
Other neonatal hypoglycaemia
7.8
42.7
63
89
P39.9
ICD-10 Finland
Infection specific to the perinatal period, unspecified
14.4
40.7
38
28
WX722
NOMESCO Finland
PEEP
7.5
40.6
62
91
P05.1
ICD-10 Finland
Small for gestational age
10.9
32.3
36
35
P22.1
ICD-10 Finland
Transient tachypnoea of newborn
6.5
30.4
53
89
P22.0
ICD-10 Finland
Respiratory distress syndrome of newborn
11.2
28.5
31
29
P00.8
ICD-10 Finland
Fetus and newborn affected by other maternal conditions
+∞
26.2
25
*
P02.1
ICD-10 Finland
Fetus and newborn affected by other forms of placental separation and haemorrhage
+∞
26.2
25
*
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
4.2
25.7
77
207
P70.0
ICD-10 Finland
Syndrome of infant of mother with gestational diabetes
7.8
24.5
35
47
P07.1
ICD-10 Finland
Other low birth weight
108.0
19.6
21
*
602
Kela drug reimbursment
Children's severe malnutrition
3.7
17.4
58
167
P05.0
ICD-10 Finland
Light for gestational age
14.8
16.4
27
19
P07.2
ICD-10 Finland
Extreme immaturity
19.1
16.0
24
13
P03.3
ICD-10 Finland
Fetus and newborn affected by delivery by vacuum extractor [ventouse]
+∞
14.6
14
*
P02.7
ICD-10 Finland
Fetus and newborn affected by chorioamnionitis
+∞
14.6
14
*
WW805
NOMESCO Finland
Transfer from treating institution to lower-Level care, accompanied by paramedic/nurse
27.8
14.3
19
7
P22.9
ICD-10 Finland
Respiratory distress of newborn, unspecified
5.9
13.6
25
44
P03.0
ICD-10 Finland
Fetus and newborn affected by breech delivery and extraction
+∞
12.5
12
*
P07.10
ICD-10 Finland
Other low birth weight 1000-1499 g
20.4
12.5
18
9
H35.1
ICD-10 Finland
Retinopathy of prematurity
27.1
12.0
16
6
P36.90
ICD-10 Finland
Suspected bacterial sepsis of newborn
5.4
11.9
24
46
P04.1
ICD-10 Finland
Fetus and newborn affected by other maternal medication
+∞
11.4
11
*
P00.2
ICD-10 Finland
Fetus and newborn affected by maternal infectious and parasitic diseases
+∞
11.4
11
*
A11JC
ATC
Vitamins, other combinations
10.8
10.8
20
19
P27.1
ICD-10 Finland
Bronchopulmonary dysplasia originating in the perinatal period
10.8
10.8
20
19
P01.11
ICD-10 Finland
Fetus and newborn affected by premature rupture of membranes more than 7 days before delivery
+∞
10.4
10
*
P03.1
ICD-10 Finland
Fetus and newborn affected by other malpresentation, malposition and disproportion during labour and delivery
+∞
10.4
10
*
P21.0
ICD-10 Finland
Severe birth asphyxia
12.2
10.3
18
15
WX882
NOMESCO Finland
High dependency care
2.2
9.7
87
424
P04.2
ICD-10 Finland
Fetus and newborn affected by maternal use of tobacco
+∞
9.4
9
*
P04.4
ICD-10 Finland
Fetus and newborn affected by maternal use of drugs of addiction
+∞
9.4
9
*
Z76.2
ICD-10 Finland
Health supervision and care of other healthy infant and child
5.0
9.2
20
41
R4110
NOMESCO Finland
Physiotherapy
1.8
8.6
154
959
P70.1
ICD-10 Finland
Syndrome of infant of a diabetic mother
7.5
8.4
19
26
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.0
8.2
101
553
K40.9
ICD-10 Finland
Unilateral or unspecified inguinal hernia, without obstruction or gangrene
3.2
7.9
32
104
J45.1
ICD-10 Finland
Nonallergic asthma
2.1
7.8
77
388
Z2446
NOMESCO Finland
Social worker
1.9
7.8
112
647
RK312, ,
NOMESCO Finland
9.5
7.8
15
16
JAB00
NOMESCO Finland
Division and ligature of inguinal hernia sac
3.4
7.6
27
81
WX730
NOMESCO Finland
Conventional respirator
4.5
7.4
18
41
P22.8
ICD-10 Finland
Other respiratory distress of newborn
7.4
7.2
16
22
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.9
6.7
100
582
J45.8
ICD-10 Finland
Mixed asthma
3.7
6.4
20
55
P29.31
ICD-10 Finland
Persistent fetal circulation
14.4
6.4
10
7
P29.30
ICD-10 Finland
Delayed closure of the ductus arteriosus
9.3
6.3
12
13
P01.8
ICD-10 Finland
Fetus and newborn affected by other maternal complications of pregnancy
+∞
6.2
6
*
P02.6
ICD-10 Finland
Fetus and newborn affected by other and unspecified conditions of umbilical cord
+∞
6.2
6
*

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
18
55
3.32
4.97
1.0
1.0
—
—
—
0
0
13
26
5.04
4.61
1.0
1.0
162.77
163.19
g/l
0.01
13
26
13
40
3.27
3.11
1.1
1.1
—
—
—
0
0
16
65
2.48
2.74
1.0
1.1
—
—
—
0
0
17
76
2.25
2.40
1.0
1.0
—
—
—
0
0
126
972
1.37
2.38
3.4
2.7
—
—
—
0
0
18
83
2.18
2.37
1.1
1.4
6.50
4.20
u/ml
—
8
56
257
2204
1.31
2.34
3.9
3.6
34.87
35.47
mmol/mol
0.46
242
2094
75
999
0.70
2.20
2.3
3.3
74.11
81.80
ug/g
0.16
62
822
85
638
1.38
1.90
1.5
1.5
245.82
443.50
u/ml
0.68
80
599
258
2255
1.26
1.88
8.3
10.5
5.94
5.93
mmol/l
0.05
244
2126
38
244
1.58
1.85
2.2
2.1
0.00
0.00
estimate
—
6
68
141
1149
1.29
1.80
17.4
12.4
7.40
7.41
ph
2.84
122
920
10
214
0.45
1.76
1.1
1.0
—
—
—
0
0
11
227
0.47
1.76
2.2
1.6
—
—
—
0
0
129
1043
1.30
1.75
12.1
14.4
1.45
1.36
mmol/l
1.93
123
996
0
47
0.00
1.71
0.0
1.2
—
18.33
—
0
12
0
47
0.00
1.71
0.0
1.2
—
29.52
—
0
9
7
159
0.43
1.70
2.0
5.7
—
—
—
0
0
126
1021
1.29
1.67
17.5
12.1
—
—
—
0
0
129
1050
1.29
1.65
17.6
11.7
24.16
23.92
mmol/l
0.68
129
1045
138
1134
1.28
1.64
2.7
4.2
—
—
—
0
0
257
2273
1.24
1.60
5.8
6.3
145.11
129.32
u/l
1.72
251
2144
243
2137
1.24
1.59
17.1
16.2
1.23
1.23
mmol/l
0.04
230
2011
176
1495
1.25
1.58
5.9
5.5
12.15
23.13
e6/l
2.09
129
1095
0
42
0.00
1.53
0.0
1.2
—
—
—
0
0
164
1388
1.25
1.51
5.6
5.2
0.21
0.20
e6/l
0.04
117
986
52
374
1.42
1.51
2.2
2.0
—
—
—
0
0
29
185
1.58
1.48
1.8
1.9
—
—
—
0
0
43
300
1.45
1.47
1.7
1.3
—
—
—
0
0
114
931
1.27
1.42
4.9
4.6
2.11
2.38
e6/l
0.17
67
492
0
37
0.00
1.35
0.0
1.0
—
—
—
0
0
5
17
2.92
1.34
1.2
1.2
—
—
—
0
0
10
189
0.51
1.29
1.5
4.9
3.60
3.27
mmol/l
—
10
182
20
121
1.66
1.27
1.2
1.3
448.00
374.85
ug/g
—
9
70
127
1075
1.22
1.15
18.0
12.2
9.47
9.75
kpa
0.91
122
1044
113
945
1.23
1.15
4.6
4.3
6.22
7.35
e6/l
0.52
92
848
40
528
0.73
1.14
1.8
1.8
—
—
—
0
0
47
605
0.74
1.14
1.7
1.7
—
—
—
0
0
15
88
1.70
1.08
4.8
9.4
7.39
7.39
ph
0.18
15
88
5
21
2.37
1.07
1.2
8.4
45.10
38.02
%
—
5
21
226
2030
1.18
1.07
18.3
18.4
1.23
1.23
mmol/l
0.16
220
1952
10
176
0.55
1.05
2.5
4.2
36.41
37.22
%
—
10
176
19
120
1.59
1.05
6.0
5.9
2.10
2.43
ug/l
0.30
19
120
51
638
0.77
1.02
1.7
1.7
—
—
—
0
0
93
772
1.23
1.02
4.4
4.5
—
—
—
0
0
19
123
1.55
0.96
1.7
1.6
—
—
—
0
0
52
643
0.78
0.96
1.6
1.7
—
—
—
0
0
7
128
0.53
0.89
1.9
4.6
—
—
—
0
0
106
907
1.20
0.87
3.8
4.0
580.72
587.96
mosm/kgh2o
0.09
81
801
79
657
1.22
0.86
4.0
4.0
2.62
2.55
g/l
0.48
74
625
53
644
0.79
0.86
1.7
1.8
—
—
—
0
0
81
677
1.22
0.85
11.5
16.7
0.80
0.81
mmol/l
0.36
76
660
35
265
1.33
0.81
1.0
1.0
-3.59
-2.36
mmol/l
—
9
69
35
265
1.33
0.81
1.0
1.0
7.58
7.25
kpa
0.40
26
222
35
265
1.33
0.81
1.0
1.0
—
—
—
0
0
197
1782
1.15
0.81
7.7
6.5
51.14
52.69
e6/l
0.02
132
1142
53
638
0.80
0.80
1.6
1.7
—
—
—
0
0
18
121
1.49
0.80
1.6
1.5
—
—
—
0
0
10
58
1.72
0.77
2.2
2.6
—
—
—
0
0
22
297
0.72
0.76
1.3
1.2
—
—
—
0
0
35
440
0.77
0.76
1.3
1.2
1.07
6.14
u/ml
1.40
11
131
54
644
0.81
0.75
2.2
1.7
—
—
—
0
0
38
470
0.78
0.73
1.3
1.2
13.24
18.80
iu/ml
—
10
96
28
209
1.34
0.72
1.2
1.3
202.10
237.86
miu/ml
—
10
96
46
555
0.80
0.72
2.5
4.9
8.65
8.57
g/l
0.06
46
538
20
271
0.72
0.71
4.4
2.6
161.57
94.85
au/ml
—
7
120
7
40
1.74
0.71
1.9
1.8
—
—
—
0
0
9
140
0.63
0.70
15.9
26.5
11.32
11.30
%
—
9
140
34
263
1.30
0.70
1.0
1.0
2.65
3.38
kpa
2.45
25
220
18
125
1.44
0.70
1.2
1.8
7.96
4.46
ug/l
0.42
18
117
28
212
1.32
0.67
4.9
4.6
0.47
0.15
e6/l
0.48
28
200
37
452
0.79
0.65
2.1
2.1
—
—
—
0
0
17
229
0.72
0.60
1.9
1.9
—
—
—
0
0
158
1435
1.13
0.59
6.7
10.3
38.64
26.46
umol/l
1.62
142
1331
13
183
0.69
0.59
1.8
5.2
—
—
—
0
0
182
1668
1.12
0.59
2.2
2.3
—
—
—
0
0
6
35
1.70
0.57
1.5
1.2
—
—
—
0
0
73
630
1.17
0.57
2.1
1.9
—
—
—
0
0
21
270
0.76
0.56
4.4
2.5
—
—
—
0
0
83
924
0.87
0.56
2.3
1.8
—
—
—
0
0
60
685
0.85
0.56
1.3
1.3
—
66.82
—
0
5
10
146
0.67
0.55
1.2
1.2
60.80
258.76
iu/ml
—
5
37
6
37
1.61
0.55
1.8
1.3
31.43
38.75
nmol/l
—
6
32
400
3842
1.13
0.53
8.7
10.7
24.86
24.74
u/l
0.03
387
3727
9
61
1.47
0.53
5.9
5.1
25.87
25.52
ug/l
—
9
61
13
90
1.44
0.53
1.2
1.4
—
—
—
0
0
229
2137
1.11
0.52
8.9
12.0
—
—
—
0
0
93
824
1.14
0.52
2.0
1.9
—
—
—
0
0
42
349
1.21
0.51
1.0
1.0
9.15
8.62
mu/l
0.13
35
301
13
91
1.42
0.50
7.8
8.2
—
—
—
0
0
24
187
1.28
0.50
1.2
1.2
—
—
—
0
0
140
1276
1.12
0.50
3.9
3.4
—
0.29
—
0
7
7
107
0.64
0.49
1.1
2.1
165.57
138.27
ng/l
—
7
102
7
45
1.54
0.48
6.3
8.5
0.90
0.88
%
—
7
40
39
324
1.20
0.48
1.6
1.4
—
—
—
0
0
15
110
1.36
0.46
2.2
2.0
3.42
3.96
iu/l
—
5
46
11
151
0.71
0.46
1.5
1.2
—
—
—
0
0
90
981
0.89
0.46
3.8
3.2
1.02
1.02
kg/l
1.13
65
598
16
206
0.76
0.45
1.1
1.2
—
—
—
0
0
336
3212
1.10
0.44
4.1
3.8
14.60
14.46
pmol/l
0.48
306
2906
52
587
0.86
0.44
5.9
9.1
4.62
6.17
umol/l
1.18
39
480
50
429
1.17
0.44
2.3
2.0
—
—
—
0
0
36
301
1.20
0.42
10.9
9.4
287.07
338.47
mg/l
0.19
29
247
8
56
1.42
0.42
7.4
8.1
1.35
1.30
%
—
8
51
12
86
1.39
0.42
1.0
1.1
—
—
—
0
0
44
375
1.17
0.42
3.8
4.1
63.40
146.25
mg/l
0.86
39
296
177
1647
1.09
0.42
4.5
3.7
6.28
6.37
ph
0.54
85
736
33
274
1.20
0.42
10.0
5.8
1.00
0.41
%
0.55
18
107
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
20
157
1.27
0.41
1.1
1.1
4.62
10.71
u/ml
—
5
23
5
34
1.46
0.40
1.2
1.1
—
—
—
0
0
300
2862
1.09
0.39
9.7
13.2
3.39
3.46
e9/l
0.23
238
2336
206
1936
1.09
0.39
4.9
4.2
0.00
0.00
estimate
-0.00
27
327
10
135
0.73
0.39
3.7
2.7
—
—
—
0
0
5
35
1.42
0.39
1.0
1.2
0.16
0.15
nmol/l
—
5
30
26
308
0.83
0.38
1.3
1.6
—
—
—
0
0
99
899
1.11
0.38
4.5
4.0
0.00
0.00
estimate
-0.00
25
316
32
371
0.84
0.38
1.7
2.5
26.65
30.93
u/l
0.39
23
298
275
2617
1.08
0.38
8.7
11.5
8.37
8.43
%
0.17
263
2510
46
517
0.87
0.38
2.8
4.2
2695.50
1127.81
ng/l
0.50
24
290
17
132
1.28
0.38
2.1
2.2
—
—
—
0
0
31
360
0.84
0.38
2.7
2.2
221.61
159.98
u/ml
0.52
18
169
112
1026
1.10
0.37
3.4
3.2
2.42
2.41
mmol/l
0.54
105
960
367
3536
1.09
0.37
4.7
4.3
2.10
2.01
mu/l
0.80
347
3366
9
69
1.29
0.37
1.1
1.1
33.62
31.37
iu/ml
—
9
69
9
69
1.29
0.37
2.4
2.9
—
—
—
0
0
11
144
0.75
0.36
1.5
1.3
—
—
—
0
0
5
76
0.65
0.36
1.6
1.4
—
178.82
—
0
17
53
466
1.14
0.35
3.3
2.4
12038.31
7117.04
u/l
0.29
15
124
6
42
1.42
0.35
1.0
1.2
—
—
—
0
0
59
523
1.13
0.35
2.7
2.3
48.86
38.58
ng/l
0.10
29
199
12
90
1.33
0.34
1.2
1.4
—
—
—
0
0
6
45
1.32
0.33
4.7
4.4
2.00
1.69
mmol/l
—
6
45
6
86
0.69
0.33
1.7
2.3
—
—
—
0
0
203
1919
1.08
0.32
4.8
4.1
0.00
0.00
estimate
-0.00
26
337
13
100
1.29
0.31
1.1
1.0
1.36
1.54
g/l
1.94
13
100
42
367
1.14
0.31
4.4
4.6
6.15
48.10
mg/mmol
0.56
37
289
32
274
1.16
0.31
10.4
6.6
0.06
0.00
%
0.48
17
95
87
927
0.91
0.31
3.2
6.5
1.07
1.18
inr
1.05
68
770
95
873
1.09
0.30
4.7
4.5
7.38
7.38
ph
0.45
64
586
17
204
0.82
0.30
1.0
1.3
—
—
—
0
0
93
855
1.09
0.29
2.2
2.0
—
—
—
0
0
13
101
1.28
0.29
1.1
1.1
0.86
0.81
g/l
0.42
13
101
204
1935
1.07
0.29
4.9
4.1
45.93
0.00
estimate
0.49
27
327
15
182
0.81
0.29
10.7
22.3
71.27
69.66
%
0.11
15
182
53
577
0.90
0.28
1.6
1.6
297.14
510.62
titre
—
7
81
8
61
1.30
0.28
3.4
4.3
—
—
—
0
0
12
93
1.28
0.28
2.4
2.7
—
10.35
—
0
6
9
118
0.75
0.27
1.6
5.0
—
—
—
0
0
420
4209
0.92
0.27
14.5
13.3
21.50
23.49
mg/l
0.65
318
3027
8
64
1.24
0.27
1.1
1.0
—
—
—
0
0
12
148
0.80
0.27
2.3
2.0
3.32
4.88
u/ml
0.20
12
148
5
74
0.66
0.26
1.2
1.8
—
—
—
0
0
413
4139
0.93
0.26
19.0
19.1
13.26
13.14
%
1.22
406
4087
29
251
1.15
0.25
1.1
1.2
—
36.24
—
0
10
50
450
1.11
0.25
12.4
10.4
59.16
50.64
ng/l
0.62
50
445
47
422
1.11
0.24
1.6
1.3
152.12
140.88
u/ml
0.07
16
127
11
86
1.27
0.24
4.1
3.2
28.55
35.73
mmol/l
0.66
11
86
248
2381
1.06
0.23
3.2
3.3
4.26
4.28
mmol/l
0.17
236
2282
222
2126
1.06
0.23
2.9
3.0
1.07
1.07
mmol/l
0.00
212
2016
25
216
1.15
0.23
1.2
1.1
—
—
—
0
0
244
2343
1.06
0.23
3.2
3.2
2.57
2.56
mmol/l
0.10
232
2228
5
40
1.24
0.22
1.0
1.3
—
—
—
0
0
271
2612
1.05
0.22
8.8
11.5
2.84
3.33
%
3.03
262
2507
19
161
1.17
0.22
1.3
1.3
4.44
21.67
u/ml
0.61
13
132
256
2464
1.05
0.22
2.7
2.5
5.26
5.31
mmol/l
0.34
235
2262
0
10
0.00
0.21
0.0
13.8
—
34.00
—
0
10
0
10
0.00
0.21
0.0
1.9
—
411.50
—
0
10
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
0.00
—
0
10
86
900
0.93
0.21
5.8
5.9
—
—
—
0
0
422
4119
1.07
0.21
10.3
9.2
—
—
—
0
0
0
12
0.00
0.21
0.0
2.5
—
10.45
—
0
12
0
12
0.00
0.21
0.0
4.3
—
14.33
—
0
12
0
13
0.00
0.20
0.0
12.2
—
13.60
—
0
13
0
13
0.00
0.20
0.0
4.2
—
28.38
—
0
13
270
2605
1.05
0.20
8.9
11.5
0.64
0.62
%
0.18
262
2509
75
696
1.08
0.20
3.1
6.3
1.39
2.03
mg/l
0.80
50
509
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
6
48
1.24
0.20
1.2
1.3
129.00
119.77
pmol/l
—
6
48
122
1259
0.94
0.20
3.9
3.4
0.00
0.00
estimate
0.50
21
271
42
452
0.91
0.20
10.8
18.8
106.14
105.78
mmol/l
0.21
42
452
32
285
1.12
0.20
10.4
6.6
0.82
0.42
%
0.46
17
107
289
2795
1.05
0.20
9.2
12.2
0.19
0.22
e9/l
1.99
237
2339
13
107
1.21
0.19
3.3
3.4
21.32
20.42
mmol/l
0.07
13
99
407
3973
1.06
0.18
11.3
12.0
55.59
56.98
umol/l
0.63
400
3900
73
764
0.93
0.18
1.8
3.3
57.30
55.33
u/l
0.15
67
720
14
162
0.85
0.18
1.5
1.3
0.87
2.33
u/ml
—
8
117
54
497
1.08
0.18
1.1
1.3
3.76
5.67
u/ml
0.43
41
383
94
974
0.94
0.18
2.0
1.7
98.87
96.86
pmol/l
0.15
43
512
19
213
0.88
0.17
1.8
1.5
0.20
0.20
g/l
0.01
19
206
53
489
1.08
0.17
1.1
1.3
0.61
0.95
u/ml
0.40
37
357
81
842
0.94
0.17
1.8
1.6
—
—
—
0
0
25
222
1.12
0.16
1.0
1.1
—
—
—
0
0
23
253
0.89
0.16
1.4
1.4
—
—
—
0
0
110
1130
0.95
0.16
3.8
6.1
30.85
33.65
u/l
0.57
103
1085
198
2004
0.96
0.15
1.9
2.0
1.68
3.71
u/ml
1.68
33
348
206
1988
1.04
0.15
3.7
5.4
24.08
26.35
u/l
0.57
197
1914
36
329
1.09
0.15
1.2
1.5
499.27
22559382.57
pmol/l
0.50
30
297
16
179
0.88
0.14
2.5
3.8
61.52
63.09
g/l
0.29
16
171
124
1267
0.96
0.14
2.7
3.6
2.43
2.48
mg/l
0.11
109
1146
154
1478
1.04
0.14
3.3
4.0
—
—
estimate
—
0
0
28
253
1.10
0.14
4.5
3.1
5.14
5.09
pmol/l
0.09
28
234
248
2405
1.04
0.13
4.1
4.1
40.74
47.97
ug/l
1.25
236
2310
276
2772
0.96
0.13
8.9
11.2
2.62
2.43
e9/l
1.29
227
2341
52
485
1.07
0.13
1.1
1.2
1.60
3.14
u/ml
1.18
40
360
13
147
0.87
0.13
12.2
4.0
—
—
—
0
0
273
2653
1.04
0.13
8.6
11.2
47.10
48.42
%
0.92
267
2583
9
104
0.85
0.13
1.3
1.3
—
—
—
0
0
23
249
0.91
0.13
10.0
18.4
0.61
0.61
%
0.02
23
249
112
1143
0.96
0.12
9.5
13.0
0.56
0.85
mmol/l
0.42
95
917
31
284
1.08
0.12
11.0
6.5
0.00
0.11
%
0.74
15
96
21
228
0.91
0.12
3.0
2.6
47.01
52.15
%
1.06
21
228
28
299
0.92
0.12
1.9
2.1
—
—
—
0
0
30
275
1.08
0.12
10.2
21.2
-1.00
-0.47
mmol/l
0.28
24
229
240
2331
1.03
0.12
3.1
3.1
1.41
1.42
mmol/l
0.18
228
2217
45
420
1.06
0.11
2.2
2.4
6.12
5.62
u/l
0.16
27
247
59
556
1.05
0.11
22.1
24.2
1.08
1.05
mg/l
0.22
59
550
21
189
1.10
0.11
1.9
2.3
—
—
—
0
0
21
189
1.10
0.11
1.9
2.3
—
—
—
0
0
21
189
1.10
0.11
1.9
2.3
—
—
—
0
0
21
189
1.10
0.11
1.9
2.3
—
—
—
0
0
19
206
0.91
0.11
1.3
1.7
1.18
13.84
u/ml
1.18
12
146
23
209
1.09
0.11
10.3
12.3
22.34
23.14
mmol/l
1.02
23
200
12
104
1.14
0.10
6.1
5.3
470.33
443.21
umol/l
0.21
12
99
63
649
0.95
0.10
2.1
1.9
—
—
—
0
0
27
248
1.08
0.10
1.3
1.3
3.24
2.96
mmol/l
0.85
11
148
30
277
1.07
0.10
10.2
21.1
7.39
7.38
ph
0.34
11
82
11
95
1.15
0.10
1.3
1.4
16.86
14.13
u/ml
0.06
11
90
190
1843
1.03
0.10
4.5
4.3
70.83
67.31
nmol/l
1.01
182
1758
20
215
0.92
0.10
1.4
1.3
—
—
—
0
0
23
210
1.09
0.10
11.8
26.3
0.64
0.71
%
0.51
23
210
478
4703
1.07
0.09
20.1
20.2
277.70
274.69
e9/l
0.43
461
4485
113
1146
0.97
0.09
9.4
13.1
7.37
7.37
ph
0.19
77
787
5
47
1.05
0.09
1.2
1.1
—
—
—
0
0
94
902
1.04
0.09
1.3
1.3
—
—
—
0
0
5
48
1.03
0.09
11.4
8.4
—
—
—
0
0
20
214
0.92
0.09
1.4
1.3
—
—
—
0
0
20
214
0.92
0.09
1.7
1.5
1.18
1.12
g/l
0.58
20
206
478
4705
1.06
0.08
20.0
20.1
85.80
85.87
fl
0.11
472
4647
5
64
0.77
0.08
1.0
1.1
—
—
—
0
0
17
154
1.09
0.08
1.5
1.3
—
—
—
0
0
23
212
1.08
0.08
12.0
26.1
94.80
96.07
%
0.23
23
212
10
87
1.14
0.08
2.3
1.6
429.10
400.78
mu/l
—
10
69
126
1271
0.97
0.08
2.9
2.3
—
—
—
0
0
7
67
1.03
0.08
1.3
1.0
—
—
—
0
0
380
3780
0.97
0.07
17.5
16.6
139.22
139.39
mmol/l
0.84
371
3685
6
74
0.80
0.07
1.3
1.6
—
—
—
0
0
478
4706
1.06
0.07
20.0
20.1
4.64
4.61
e12/l
0.90
459
4473
478
4706
1.06
0.07
20.0
20.1
28.91
28.85
pg
0.27
472
4649
478
4706
1.06
0.07
20.8
22.0
39.73
40.13
%
0.23
471
4650
43
407
1.05
0.07
2.3
2.3
6.93
6.77
iu/l
0.03
29
258
11
97
1.12
0.07
1.2
1.2
—
—
—
0
0
29
271
1.06
0.07
4.0
4.2
—
—
—
0
0
8
77
1.03
0.07
2.5
1.5
3.28
15.38
u/ml
—
8
68
31
322
0.95
0.07
1.0
1.2
13.82
12.37
u/ml
0.09
20
209
21
194
1.07
0.07
1.9
1.7
0.19
0.18
mg/l
—
6
75
21
221
0.94
0.06
1.6
1.7
4.31
3.46
u/ml
0.08
13
163
9
101
0.88
0.06
1.8
1.4
—
—
—
0
0
9
101
0.88
0.06
2.6
2.3
—
—
—
0
0
277
2712
1.02
0.06
8.8
11.3
37.45
36.14
%
0.97
270
2627
27
281
0.95
0.06
10.3
18.5
124.93
125.59
g/l
0.06
27
275
11
98
1.11
0.06
2.6
1.7
286.80
294.88
mosm/kgh2o
—
5
69
277
2713
1.02
0.06
8.8
11.3
0.59
0.57
e9/l
0.58
222
2213
15
160
0.92
0.06
1.3
1.3
—
—
—
0
0
380
3775
0.98
0.05
17.5
16.5
4.00
3.94
mmol/l
2.88
371
3658
33
340
0.96
0.05
1.0
1.2
6.24
8.05
u/ml
0.22
22
233
478
4709
1.05
0.05
20.3
20.6
133.43
132.28
g/l
1.06
472
4653
55
528
1.03
0.05
1.1
1.3
1.47
3.55
u/ml
1.04
40
382
17
157
1.07
0.05
2.9
3.9
8.60
8.40
index
—
10
99
277
2716
1.02
0.05
8.8
11.3
0.04
0.04
e9/l
0.33
221
2217
34
323
1.04
0.05
1.7
2.3
7.52
8.21
nmol/l
0.16
29
292
478
4710
1.04
0.05
20.1
20.2
7.16
7.08
e9/l
0.22
459
4480
192
1916
0.98
0.04
1.7
1.9
1.51
1.46
g/l
0.22
90
1006
24
248
0.95
0.04
2.3
1.8
5.97
6.35
ph
1.65
17
154
14
129
1.07
0.04
1.0
1.2
—
—
—
0
0
264
2593
1.01
0.03
11.0
13.4
0.00
0.01
e9/l
0.56
191
1949
30
305
0.97
0.02
1.0
1.2
0.15
0.97
u/ml
0.97
16
168
143
1402
1.01
0.02
1.7
1.6
—
—
—
0
0
93
909
1.01
0.02
3.7
3.3
0.00
0.00
estimate
-0.00
20
268
52
505
1.02
0.02
3.9
6.4
58.36
63.28
e9/l
0.33
32
302
106
1038
1.01
0.01
10.3
15.2
—
—
—
0
0
12
112
1.06
0.01
1.8
4.1
212.42
390.39
ug/l
0.60
12
105
35
352
0.98
0.00
2.2
1.5
—
—
—
0
0
66
658
0.99
0.00
1.7
1.5
21.04
20.13
nmol/l
0.21
58
584
52
510
1.01
0.00
2.5
2.4
—
—
—
0
0
48
478
0.99
0.00
2.2
2.0
—
—
—
0
0
173
1713
1.00
0.00
6.8
9.3
—
—
—
0
0
103
1013
1.01
0.00
1.8
2.1
1.13
1.21
mmol/l
0.53
95
944
9
92
0.97
0.00
1.1
1.2
—
0.27
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
88.50
—
0
6
0
7
0.00
-0.00
0.0
1.4
—
8.41
—
0
7
5
53
0.93
-0.00
1.4
2.9
0.94
1.44
ug/l
—
5
42
7
70
0.99
-0.00
8.1
9.8
9.54
9.18
kpa
—
7
70
7
69
1.00
-0.00
1.3
1.1
—
305.94
—
0
16
0
8
0.00
-0.00
0.0
3.9
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
25.57
—
0
7
0
9
0.00
-0.00
0.0
1.0
—
4.70
—
0
9
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
7
70
0.99
-0.00
8.0
10.4
5.16
4.85
kpa
—
7
70
7
72
0.96
-0.00
11.3
11.3
8.40
5.51
pmol/l
—
7
72
0
5
0.00
-0.00
0.0
1.2
—
36.94
—
0
5
7
77
0.90
-0.00
4.1
5.1
0.29
0.75
index
—
7
77
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.6
—
14.50
—
0
7
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.2
—
1.80
—
0
5
5
55
0.90
-0.00
1.0
2.7
17.20
23.19
u/ml
—
5
47
0
5
0.00
-0.00
0.0
1.0
—
89.60
—
0
5
9
97
0.92
-0.00
5.3
3.7
3.33
3.17
e9/l
—
9
97

Mortality – FinRegistry

↥

Association

Association between endpoint P16_FET_NEWB_MATERN_FACTO_COMPLICATIO_PREGNAC_LABOUR_DELIV and mortality.

Females

Parameter HR [95% CI] p-value
P16_FET_NEWB_MATERN_FACTO_COMPLICATIO_PREGNAC_LABOUR_DELIV 1.511 [1.16, 1.97] 0.002
Birth year 0.998 [0.99, 1.01] 0.664

During the follow-up period (1.1.1998 — 31.12.2019), 74 out of 18172 females with P16_FET_NEWB_MATERN_FACTO_COMPLICATIO_PREGNAC_LABOUR_DELIV died.

Males

Parameter HR [95% CI] p-value
P16_FET_NEWB_MATERN_FACTO_COMPLICATIO_PREGNAC_LABOUR_DELIV 1.458 [1.19, 1.79] < 0.001
Birth year 0.991 [0.98, 1.0] 0.065

During the follow-up period (1.1.1998 — 31.12.2019), 107 out of 21554 males with P16_FET_NEWB_MATERN_FACTO_COMPLICATIO_PREGNAC_LABOUR_DELIV died.

Mortality risk

Mortality risk for people of age

years, who have P16_FET_NEWB_MATERN_FACTO_COMPLICATIO_PREGNAC_LABOUR_DELIV.

N-year risk Females Males
1 0.105% 0.363%
5 0.922% 1.99%
10 2.39% 4.812%
15 4.726% 9.086%
20 8.271% 14.988%

Relationships between endpoints

↥

Index endpoint: P16_FET_NEWB_MATERN_FACTO_COMPLICATIO_PREGNAC_LABOUR_DELIV – Fetus and newborn affected by maternal factors and by complications of pregnancy, labour and delivery

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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