Hepatitis, Alcoholic: INFLAMMATION of the LIVER due to ALCOHOL ABUSE. It is characterized by NECROSIS of HEPATOCYTES, infiltration by NEUTROPHILS, and deposit of MALLORY BODIES. Depending on its severity, the inflammatory lesion may be reversible or progress to LIVER CIRRHOSIS.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
382 |
4. Check minimum number of eventsNone |
382 |
5. Include endpointsNone |
382 |
6. Filter based on genotype QC (FinnGen only) |
335 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- K73
Similar endpoints
↥List of similar endpoints to
Nonalcoholic steatohepatitis
based on the number of shared cases.
Similar with more cases:
- Chronic hepatitis, not elsewhere classified
- Diseases of liver
- Gastrointestinal diseases
- Any operation in hilmo
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1036 | 555 | 476 |
| Only index persons | 1025 | 553 | 472 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 56.00 | 59.82 | 51.78 |
| Only index persons | 56.32 | 60.05 | 51.94 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 335 | 196 | 139 |
| Unadjusted period prevalence (%) | 0.07 | 0.07 | 0.06 |
| Median age at first event (years) | 59.21 | 59.01 | 59.48 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 354
- Matched controls
- 3540
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K73.80
ICD-10 Finland
Non-alcoholic fatty liver (NASH, Non Alcoholic Steatohepatitis)
+∞
307.7
354
7
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
56.0
252.2
154
48
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
62.6
199.8
115
27
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
44.1
111.1
68
19
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
10.8
92.9
125
171
A10BG03
ATC
pioglitazone; oral
28.8
77.9
54
22
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
10.7
76.4
97
121
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
6.5
69.0
179
479
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
10.0
67.4
88
113
A10BJ06
ATC
semaglutide; parenteral
9.7
63.2
84
110
215
Kela drug reimbursment
Diabetes, non-insulin-treated
5.9
62.4
187
561
103
Kela drug reimbursment
Diabetes, insulin-treated
5.8
60.4
187
574
A10BA02
ATC
metformin; oral
5.5
57.4
193
630
T90
ICPC
Diabetes non-insulin dependent
5.4
54.7
178
561
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
16.1
54.7
49
35
A10BH01
ATC
sitagliptin; oral
6.9
49.5
90
166
E66.00
ICD-10 Finland
Metabolic syndrome
8.2
47.2
70
103
E66.01
ICD-10 Finland
Obesity due to excess calories
6.0
45.8
100
219
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
5.5
36.9
85
193
A10AE04
ATC
insulin glargine; parenteral
5.6
35.1
78
171
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.7
32.1
162
655
A10BH05
ATC
linagliptin; oral
8.1
30.8
44
61
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.4
29.9
92
262
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
35.3
29.7
38
12
E66.8
ICD-10 Finland
Other obesity
5.8
28.9
58
115
C03DA01
ATC
spironolactone; oral
4.6
28.2
78
204
160
Kela drug reimbursment
exenatide
10.0
27.8
33
36
A10BK03
ATC
empagliflozin; oral
4.4
27.3
81
223
E11
ICD-10 Finland
Type 2 diabetes mellitus
3.8
26.7
102
337
A10BJ02
ATC
liraglutide; parenteral
7.9
26.4
38
53
A10BJ05
ATC
dulaglutide; parenteral
9.8
24.2
29
32
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
37.8
22.4
28
8
A10BK01
ATC
dapagliflozin; oral
4.5
22.3
60
152
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
8.7
22.1
29
36
K76.9
ICD-10 Finland
Liver disease, unspecified
19.0
21.8
33
19
E11.6
ICD-10 Finland
Type 2 diabetes mellitus, with other specified complications
8.8
20.8
27
33
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
7.8
20.2
29
40
SPAT1262
SPAT
Handing over of treatment supplies
3.4
20.2
90
324
A07AA11
ATC
rifaximin; oral
211.3
19.8
20
*
I10
ICD-10 Finland
Essential (primary) hypertension
2.8
18.4
245
1564
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.9
18.3
118
523
E11.2
ICD-10 Finland
Type 2 diabetes mellitus, with renal complications
7.8
17.6
25
34
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
23.3
17.1
24
11
C03CA01
ATC
furosemide; systemic
2.9
17.1
106
458
Z01.8
ICD-10 Finland
Other specified special examinations
2.8
16.8
115
523
G47.3
ICD-10 Finland
Sleep apnoea
2.7
16.5
128
618
A10AB05
ATC
insulin aspart; parenteral
4.2
16.5
48
128
R18
ICD-10 Finland
Ascites
13.1
16.1
28
23
205
Kela drug reimbursment
Chronic hypertension
2.8
16.1
100
431
JN3AD
NOMESCO Finland
Abdominal CT examination
3.2
16.0
74
270
T82
ICPC
Obesity
4.9
15.8
37
83
R94.5
ICD-10 Finland
Abnormal results of liver function studies
14.7
15.8
26
19
N02AX02
ATC
tramadol; systemic, rectal
2.4
14.5
189
1146
OAB50, ,
SPAT
3.6
13.4
49
153
A10AC01
ATC
insulin (human); parenteral
3.8
12.8
42
122
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
2.4
12.7
117
601
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.3
12.7
159
932
TPH04
NOMESCO Finland
Cathetrisation of vein
2.5
12.6
101
487
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
5.1
12.6
27
56
A10BX04
ATC
[U] exenatide
16.6
12.3
19
12
R03AC02
ATC
salbutamol; inhalant
2.3
11.9
228
1575
E66.9
ICD-10 Finland
Obesity, unspecified
4.7
11.7
28
64
J01MA02
ATC
ciprofloxacin; systemic
2.2
11.6
153
909
H02AB04
ATC
methylprednisolone; systemic
2.7
11.1
67
280
WX892
NOMESCO Finland
Monitored bed care
3.5
11.1
41
129
C22.0
ICD-10 Finland
Malignant neoplasm: Liver cell carcinoma
44.8
11.0
13
*
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.5
10.9
39
120
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
2.8
10.8
60
240
UJF30
NOMESCO Finland
Ileoscopy through colon
2.9
10.8
54
204
UJF32
NOMESCO Finland
Coloscopy
2.3
10.7
105
550
A10BD07
ATC
metformin and sitagliptin; systemic
4.4
10.6
27
65
R4190
NOMESCO Finland
Nutritional therapy
4.2
10.5
29
74
C07AG02
ATC
carvedilol; oral
4.1
10.4
30
79
XW000
NOMESCO Finland
Bone marrow biopsy
4.6
10.0
24
55
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.3
9.9
87
433
K74.0
ICD-10 Finland
Hepatic fibrosis
26.9
9.9
13
5
D64.9
ICD-10 Finland
Anaemia, unspecified
3.1
9.7
43
151
J45.9
ICD-10 Finland
Asthma, unspecified
2.3
9.7
86
430
C08CA13
ATC
lercanidipine; oral
2.6
9.6
63
273
JJC00
NOMESCO Finland
Allogenic transplantation of liver
102.7
9.5
10
*
JCA22
NOMESCO Finland
Endoscopic ligature of oesophageal varices
30.9
9.5
12
*
M01AB01
ATC
indometacin; systemic, rectal
3.6
9.4
32
95
D97
ICPC
Liver disease NOS
22.4
9.4
13
6
K73.89
ICD-10 Finland
Other long-term hepatitis, not classified differently
+∞
9.4
9
*
D07AC01
ATC
betamethasone; topical
2.0
9.2
148
929
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.8
9.1
50
198
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.6
9.1
58
248
Z94.4
ICD-10 Finland
Liver transplant status
37.7
9.1
11
*
JA2AT
NOMESCO Finland
Abdominal puncture with ultrasound guidance
24.8
9.0
12
5
E66
ICD-10 Finland
Obesity
3.2
8.9
37
125
J01FF01
ATC
clindamycin; systemic
2.1
8.8
111
635
D07XC01
ATC
betamethasone; topical
2.5
8.7
58
253
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.8
8.7
45
173
TPH07
NOMESCO Finland
Cathetrisation of artery
2.8
8.7
47
185
A10BX07
ATC
[U] liraglutide
9.3
8.6
17
19
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
10.4
8.6
16
16
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
2.6
8.6
55
236
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.5
8.5
62
282
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
5.1
8.5
18
37
C10AC01
ATC
colestyramine; oral
4.8
8.5
19
41
C08CA01
ATC
amlodipine; oral
2.0
8.4
137
858
L04AX01
ATC
azathioprine; systemic
4.3
8.4
22
54
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
+∞
8.4
8
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
8.2
178
1223
R4110
NOMESCO Finland
Physiotherapy
2.0
8.1
112
661
A06AD11
ATC
lactulose; oral
2.6
8.0
48
199
A02BC02
ATC
pantoprazole; systemic
2.0
8.0
253
1965
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
4.8
8.0
18
39
C07AB12
ATC
nebivolol; oral
4.7
7.7
18
40
J01DB01
ATC
cefalexin; oral
2.4
7.7
307
2578
C09AA02
ATC
enalapril; systemic
2.3
7.7
69
343
R29
ICPC
Respiratory symptom/complaint other
2.9
7.7
38
142
A10BB12
ATC
glimepiride; oral
3.7
7.7
25
72
A05AA02
ATC
ursodeoxycholic acid; oral
8.3
7.7
16
20
C09BA02
ATC
enalapril and diuretics; systemic
3.1
7.7
33
114
UJF92
NOMESCO Finland
Capsular endoscopy
6.4
7.7
19
31
K73.9
ICD-10 Finland
Chronic hepatitis, unspecified
18.9
7.6
11
6
K29.7
ICD-10 Finland
Gastritis, unspecified
4.3
7.6
20
49
C09DA01
ATC
losartan and diuretics; oral
2.6
7.6
47
198
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
3.0
7.6
35
126
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.4
7.6
28
88
UKC02
NOMESCO Finland
Cystoscopy
2.4
7.5
55
251
WX002
NOMESCO Finland
Sedation and analgesia
2.2
7.4
75
392
C10AA05
ATC
atorvastatin; oral
1.9
7.4
152
1018
N30.0
ICD-10 Finland
Acute cystitis
2.3
7.3
64
315
K72.1
ICD-10 Finland
Chronic hepatic failure
+∞
7.3
7
*
K73.8
ICD-10 Finland
Other chronic hepatitis, not elsewhere classified
+∞
7.3
7
*
M04AA01
ATC
allopurinol; systemic
2.5
7.3
47
202
QXB99, ,
SPAT
4.6
7.3
17
38
N17.9
ICD-10 Finland
Acute renal failure, unspecified
4.6
7.3
17
38
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
2.5
7.2
50
222
H02AB07
ATC
prednisone; oral
2.4
7.2
56
262
K72.9
ICD-10 Finland
Hepatic failure, unspecified
30.7
7.2
9
*
K76.7
ICD-10 Finland
Hepatorenal syndrome
30.7
7.2
9
*
162
Kela drug reimbursment
liraglutide
8.2
7.2
15
19
K70.0
ICD-10 Finland
Alcoholic fatty liver
20.5
7.2
10
5
P06
ICPC
Sleep disturbance
2.2
7.2
64
318
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
2.0
7.1
102
605
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.1
7.1
79
428
R5140
NOMESCO Finland
Monitoring the use of the aid
2.3
7.1
56
264
L02.2
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of trunk
3.3
7.0
27
87
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.5
7.0
45
193
M01AE03
ATC
ketoprofen; systemic, rectal
1.8
6.9
136
893
R50.9
ICD-10 Finland
Fever, unspecified
2.2
6.9
63
315
N03AX16
ATC
[U] pregabalin
2.0
6.9
90
516
D07AC13
ATC
mometasone; topical
1.9
6.8
113
703
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.0
6.8
19
49
I85.0
ICD-10 Finland
Oesophageal varices with bleeding
40.9
6.8
8
*
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
40.9
6.8
8
*
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
40.9
6.8
8
*
L40.0
ICD-10 Finland
Psoriasis vulgaris
3.6
6.7
22
64
N06AX11
ATC
mirtazapine; oral
1.8
6.6
133
878
N06AB10
ATC
escitalopram; oral
2.0
6.5
86
495
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.3
6.5
55
267
H02AB06
ATC
prednisolone; systemic
1.8
6.5
172
1231
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.4
6.5
48
220
WZC00
NOMESCO Finland
Treatment plan or consultation
1.8
6.4
141
954
A10AE05
ATC
insulin detemir; parenteral
3.2
6.3
25
82
JJA20
NOMESCO Finland
Open biopsy of liver
27.2
6.3
8
*
K29.3
ICD-10 Finland
Chronic superficial gastritis
4.1
6.2
17
43
K42.9
ICD-10 Finland
Umbilical hernia without obstruction or gangrene
3.0
6.2
27
94
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
3.7
6.1
19
53
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.0
6.1
72
397
E83.1
ICD-10 Finland
Disorders of iron metabolism
12.8
6.1
10
8
A10BJ01
ATC
exenatide; parenteral
8.8
6.1
12
14
C10AA07
ATC
rosuvastatin; oral
1.8
6.1
137
930
E14.9
ICD-10 Finland
Unspecified diabetes mellitus, without complications
6.9
6.1
14
21
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
189
102
38.61
257.88
1.3
1.2
176.32
118.82
titre
0.35
19
17
192
227
17.30
166.91
1.5
1.6
1.25
1.53
g/l
0.69
178
210
201
278
15.42
155.61
2.1
2.8
11.02
10.58
g/l
0.65
187
259
195
290
13.74
141.50
3.9
2.5
0.22
0.23
g/l
0.12
183
272
86
34
33.09
127.18
1.2
1.2
—
—
—
0
0
219
474
10.49
112.98
2.8
2.4
2.54
2.36
g/l
3.55
213
439
210
434
10.44
112.85
2.9
2.4
23.94
24.46
%
0.19
204
407
319
1182
18.18
95.82
8.2
3.2
49.79
30.98
u/l
14.00
313
1122
176
394
7.90
84.00
5.1
2.7
8.73
6.96
umol/l
0.55
165
353
310
1316
11.91
73.89
11.5
5.1
36.77
36.30
g/l
0.79
300
1247
105
178
7.96
63.45
2.3
1.5
0.38
0.30
mg/l
0.33
38
83
163
456
5.77
58.26
2.1
1.9
1.51
1.45
%
0.67
145
400
208
726
5.52
56.92
1.9
1.4
3.19
2.33
g/l
4.28
170
451
278
1393
5.64
44.70
14.8
9.7
1.12
1.14
inr
0.66
246
1133
282
1489
5.39
40.74
4.7
2.9
196.64
114.32
ug/l
5.09
270
1409
230
1095
4.14
36.95
5.0
3.3
7.67
7.85
mmol/l
0.25
205
935
221
1033
4.03
36.26
5.7
4.1
6.16
8.37
mg/mmol
0.52
160
632
191
811
3.94
36.10
1.5
1.3
0.93
1.82
u/ml
0.93
35
235
36
32
12.41
35.00
1.1
1.0
—
—
—
0
0
54
98
6.32
29.48
1.3
1.3
—
—
—
0
0
168
731
3.47
29.11
3.0
2.1
2.98
2.89
mg/l
0.16
151
635
205
1039
3.31
27.07
5.5
2.5
51.83
62.81
u/l
1.58
196
977
332
2336
7.78
25.88
10.9
3.3
132.39
48.33
u/l
11.62
323
2230
234
1324
3.26
24.84
2.7
2.0
96.13
98.63
pmol/l
0.29
132
669
282
1849
3.58
22.08
12.0
10.4
4.13
4.01
e9/l
0.36
244
1611
236
1411
3.02
21.43
3.4
2.5
69.74
75.64
nmol/l
2.78
216
1290
271
1789
3.20
19.83
7.6
5.1
7.97
6.60
mmol/l
8.92
266
1704
53
151
3.95
16.70
2.0
2.5
56.52
40.57
u/l
2.83
46
138
117
542
2.73
16.40
3.6
3.5
0.79
0.82
mmol/l
1.61
110
518
156
834
2.56
16.30
3.7
2.6
366.24
339.01
umol/l
2.33
143
750
233
1503
2.61
16.26
11.4
7.6
1.21
1.21
mmol/l
0.83
216
1316
218
1367
2.55
16.09
8.7
6.6
1.20
1.22
mmol/l
1.38
210
1272
140
740
2.48
14.66
3.2
2.3
—
—
—
0
0
28
54
5.54
14.15
1.3
1.6
—
—
—
0
0
164
956
2.33
13.52
2.9
2.1
195.46
265.66
u/l
0.39
158
912
348
3068
8.92
13.27
8.7
4.9
6.83
5.90
mmol/l
15.89
337
2874
41
115
3.90
13.13
2.5
2.0
1.20
1.47
g/l
1.05
33
103
58
206
3.17
12.96
2.5
1.7
—
—
—
0
0
29
64
4.85
12.60
1.2
1.2
336.44
243.97
u/ml
0.61
16
33
30
70
4.59
12.20
8.1
7.4
189.57
125.67
iu/ml
—
7
9
97
472
2.45
11.80
2.1
2.0
—
—
—
0
0
73
312
2.69
11.60
3.0
2.4
30.33
32.88
u/l
0.22
60
261
212
1436
2.19
11.47
4.5
2.8
—
—
estimate
—
0
0
26
57
4.84
11.37
2.4
3.2
—
1367.00
—
0
5
29
70
4.42
11.30
1.6
2.0
—
—
—
0
0
145
853
2.19
11.18
2.0
1.6
20.00
20.97
nmol/l
0.38
133
729
47
168
3.07
10.32
5.2
3.3
0.41
1.63
mmol/l
1.04
37
126
294
2338
2.52
9.98
7.5
4.3
14.91
10.39
mm/h
5.82
281
2193
76
358
2.43
9.77
2.0
1.8
—
—
—
0
0
57
243
2.60
9.00
2.0
2.9
67.29
67.86
g/l
0.20
51
233
33
104
3.40
8.88
3.2
2.7
24.65
25.03
mmol/l
0.22
33
104
226
1658
2.00
8.84
5.0
3.4
0.00
0.00
estimate
0.50
39
341
226
1673
1.97
8.43
5.1
3.4
0.00
0.00
estimate
-0.00
39
344
227
1688
1.96
8.29
5.1
3.4
0.03
0.01
estimate
0.29
33
321
100
562
2.09
8.27
1.7
1.6
360919983.24
39501486.66
pmol/l
0.93
87
481
31
99
3.34
8.17
1.7
1.5
—
—
—
0
0
348
3197
6.22
8.15
7.6
5.1
4.43
4.76
mmol/l
8.20
335
3023
336
2943
3.79
7.97
7.3
5.2
1.98
1.88
mu/l
0.93
323
2749
14
13
11.16
7.86
3.8
3.8
4.36
4.99
ug/l
0.26
14
13
36
129
2.99
7.85
3.3
3.4
159.81
1663.10
u/ml
0.76
31
111
76
395
2.18
7.64
7.1
7.6
104.01
104.47
mmol/l
0.40
76
395
130
822
1.92
7.60
3.0
3.1
807.58
725.78
ng/l
0.12
100
683
92
518
2.05
7.49
3.3
2.7
0.97
0.84
e6/l
0.12
46
260
346
3185
4.82
7.32
7.5
5.0
1.22
1.48
mmol/l
29.63
334
2998
297
2477
2.24
7.32
5.6
4.3
14.30
14.67
pmol/l
2.13
283
2296
87
484
2.06
7.30
3.6
2.7
2.85
2.06
e6/l
0.50
43
225
340
3034
4.05
7.11
6.1
4.2
1.81
1.32
mmol/l
11.77
327
2839
156
1068
1.82
6.96
3.3
3.6
2.36
2.36
mmol/l
0.13
141
983
130
842
1.86
6.93
4.1
3.0
0.39
0.36
e6/l
0.08
91
595
199
1470
1.81
6.86
2.6
2.0
1.86
1.41
mmol/l
6.60
178
1251
109
675
1.89
6.64
1.4
1.3
32.61
30.55
iu/ml
0.07
35
231
115
728
1.86
6.53
2.2
1.7
1.73
1.15
mg/l
0.60
93
584
340
3060
3.81
6.45
27.3
13.4
84.10
84.98
ml/min/173m2
0.28
313
2815
18
47
3.98
6.34
2.2
1.6
—
—
—
0
0
76
425
2.00
6.21
2.2
1.6
1056.23
1179.25
nmol/l
0.52
61
325
38
160
2.54
6.12
1.6
1.7
—
—
—
0
0
39
167
2.50
6.07
1.5
2.0
6.58
5.29
iu/ml
—
6
45
39
169
2.47
5.92
9.6
12.4
15.06
16.19
%
1.46
39
160
64
344
2.05
5.81
2.1
1.9
—
—
—
0
0
22
72
3.19
5.60
2.1
2.8
83.10
91.06
ug/min
0.06
15
41
60
323
2.03
5.42
8.8
10.3
0.49
0.92
mmol/l
0.32
50
271
47
231
2.19
5.37
1.4
1.2
144.60
171.42
u/ml
0.28
25
95
9
8
11.50
5.32
3.8
1.6
0.57
0.61
mmol/l
—
9
8
28
111
2.65
5.10
1.5
1.5
5.16
9.11
u/ml
—
5
24
52
274
2.05
4.97
9.7
11.3
116.79
123.06
g/l
1.20
52
267
66
382
1.89
4.82
7.0
4.5
27.54
32.16
%
2.21
54
248
59
329
1.95
4.81
9.2
10.1
5.05
5.15
kpa
0.42
59
316
59
329
1.95
4.81
9.1
10.1
11.88
12.50
kpa
0.44
59
317
12
22
5.61
4.64
4.7
1.7
66.42
103.09
%
2.93
12
22
94
617
1.71
4.51
1.4
1.3
8.74
8.19
u/ml
0.03
25
245
7
6
11.87
4.29
1.0
1.0
—
—
—
0
0
16
51
3.24
4.26
1.1
1.1
—
5.29
—
0
7
25
103
2.54
4.24
2.1
3.8
37.56
38.52
mg/l
0.05
25
91
247
2076
1.63
4.22
3.4
3.2
—
—
—
0
0
26
110
2.47
4.18
10.3
10.4
1.05
0.91
%
0.59
26
101
23
92
2.60
4.14
1.7
1.9
—
—
—
0
0
8
10
8.15
4.08
1.0
1.0
—
—
—
0
0
11
22
5.12
4.03
2.1
1.7
—
—
—
0
0
23
95
2.52
3.89
1.7
2.1
—
—
—
0
0
15
49
3.15
3.85
1.0
1.1
—
—
—
0
0
15
49
3.15
3.85
1.5
1.6
—
—
—
0
0
24
103
2.43
3.76
2.2
3.8
41.10
45.14
mg/l
0.07
24
90
8
12
6.79
3.69
1.0
1.1
13.97
9.58
ug/l
—
8
12
14
46
3.13
3.57
1.6
1.7
—
—
—
0
0
89
610
1.61
3.54
3.9
3.8
58.08
244.65
ng/l
1.63
61
445
14
47
3.06
3.45
1.6
1.7
—
—
—
0
0
14
47
3.06
3.45
1.6
1.7
—
—
—
0
0
9
18
5.10
3.39
1.1
1.8
—
—
—
0
0
9
18
5.10
3.39
1.1
1.8
—
—
—
0
0
21
89
2.45
3.39
1.4
1.3
—
—
—
0
0
149
1156
1.50
3.38
4.6
3.3
20.47
81.63
ng/l
0.62
114
774
14
49
2.93
3.23
1.6
1.6
—
—
—
0
0
17
67
2.61
3.17
1.6
2.2
139.58
137.98
g/l
0.08
12
51
15
56
2.75
3.10
1.2
1.3
13.87
14.72
u/l
0.06
15
50
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
17
68
2.58
3.09
3.0
2.4
0.37
0.31
iu/ml
0.28
12
36
16
63
2.61
3.00
10.5
15.3
105.00
105.91
mmol/l
0.34
16
56
10
27
3.78
2.90
5.0
3.4
—
—
—
0
0
22
103
2.21
2.87
1.2
1.3
344.56
310.70
ug/g
—
9
59
31
169
1.91
2.73
7.9
10.5
23.78
24.82
mmol/l
0.99
31
159
13
49
2.72
2.65
1.6
1.6
—
—
—
0
0
7
15
4.74
2.61
1.4
1.2
—
—
—
0
0
41
250
1.72
2.54
2.2
2.6
74.00
69.91
ml/min/173m2
0.24
19
113
47
298
1.67
2.53
2.7
2.4
13.18
13.90
nmol/l
0.24
42
275
41
252
1.71
2.47
1.5
1.3
133.03
343.39
u/ml
1.06
41
233
6
12
5.07
2.41
1.3
3.4
178.33
196.75
u/l
—
6
12
155
1271
1.39
2.40
4.8
3.2
0.00
0.02
estimate
0.96
34
279
5
8
6.32
2.38
1.2
1.8
45.40
36.88
u/l
—
5
8
7
17
4.18
2.37
1.9
4.2
779.00
1111.88
mg
—
7
17
7
18
3.94
2.26
1.9
4.2
1404.57
696.72
u/ml
—
7
18
16
73
2.25
2.24
2.8
2.7
8.90
8.23
kpa
0.62
16
73
96
732
1.43
2.23
5.3
3.5
1.02
1.02
kg/l
2.49
74
485
17
80
2.18
2.22
4.9
2.5
2.14
1.67
index
—
7
45
18
87
2.13
2.21
1.9
1.6
—
—
—
0
0
9
30
3.05
2.16
1.4
2.1
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
7
19
3.74
2.16
1.0
1.2
—
—
—
0
0
6
14
4.34
2.16
1.0
1.9
—
—
—
0
0
6
14
4.34
2.16
1.0
1.9
—
—
—
0
0
17
82
2.13
2.10
2.7
1.9
1.94
4.52
iu/l
1.73
11
34
7
20
3.55
2.06
1.1
1.1
—
—
—
0
0
7
20
3.55
2.06
1.4
1.1
—
—
—
0
0
6
15
4.05
2.04
3.3
2.7
38.27
43.85
g/l
—
6
15
18
91
2.03
1.99
2.2
3.5
1.31
1.66
ratio
0.55
12
54
25
142
1.82
1.98
1.3
1.3
—
—
—
0
0
7
21
3.38
1.97
1.4
2.8
—
—
—
0
0
9
33
2.77
1.94
1.2
1.2
—
—
—
0
0
6
16
3.80
1.94
1.0
1.3
—
—
—
0
0
113
907
1.36
1.91
5.2
3.5
0.00
0.01
estimate
0.69
39
330
77
580
1.42
1.90
2.6
2.8
2.45
2.45
mmol/l
0.05
67
525
15
72
2.13
1.89
1.4
1.6
3547.57
18282.84
e6/l
—
7
49
9
34
2.69
1.88
1.3
1.1
—
—
—
0
0
9
34
2.69
1.88
1.4
1.9
—
—
—
0
0
18
94
1.96
1.83
1.3
1.2
—
—
—
0
0
11
47
2.38
1.79
1.0
1.5
—
—
—
0
0
11
47
2.38
1.79
1.0
1.5
—
—
—
0
0
39
260
1.56
1.75
1.3
1.5
—
—
—
0
0
10
42
2.42
1.63
1.0
1.3
0.18
0.17
nmol/l
—
5
27
5
14
3.61
1.62
1.2
1.1
—
—
—
0
0
20
114
1.80
1.60
1.2
1.5
345.33
240.90
miu/ml
—
6
53
115
951
1.31
1.55
3.7
2.7
0.29
0.01
estimate
0.46
34
276
15
83
1.84
1.33
1.5
1.1
—
—
—
0
0
15
83
1.84
1.33
1.5
1.1
—
—
—
0
0
27
178
1.56
1.30
1.3
1.3
16.79
27.32
iu/l
1.57
20
152
5
18
2.80
1.29
1.4
1.1
—
—
—
0
0
8
35
2.31
1.27
1.0
1.1
—
—
—
0
0
79
638
1.31
1.26
1.9
1.5
—
—
—
0
0
13
71
1.86
1.21
1.8
1.6
—
—
—
0
0
8
40
2.02
1.12
1.3
1.2
—
—
—
0
0
16
96
1.70
1.12
1.6
2.8
—
—
—
0
0
7
31
2.28
1.11
1.3
1.1
—
—
—
0
0
15
89
1.72
1.09
1.3
1.7
—
—
—
0
0
7
32
2.21
1.08
1.0
1.1
—
—
—
0
0
106
908
1.24
1.04
5.1
4.6
1.16
2.09
ug/l
1.92
98
833
7
34
2.08
1.03
1.3
1.2
—
—
—
0
0
7
36
1.96
0.97
1.3
1.2
—
—
—
0
0
7
36
1.96
0.97
1.3
1.2
—
—
—
0
0
7
36
1.96
0.97
1.3
1.2
—
—
—
0
0
19
125
1.55
0.96
3.0
1.7
—
—
—
0
0
0
32
0.00
0.95
0.0
1.5
—
50.78
—
0
32
7
37
1.91
0.94
1.0
1.1
—
—
—
0
0
24
168
1.46
0.92
1.1
1.0
—
—
—
0
0
6
28
2.16
0.92
1.2
1.5
—
—
—
0
0
6
30
2.02
0.87
1.2
1.2
81.33
101.37
pmol/l
—
6
30
26
188
1.41
0.86
3.2
2.6
27.30
48.56
u/ml
0.77
26
181
24
171
1.43
0.85
1.5
1.3
—
—
—
0
0
6
31
1.95
0.84
2.3
1.5
2.82
3.42
mg/l
—
6
31
0
24
0.00
0.79
0.0
2.0
—
—
—
0
0
11
68
1.64
0.72
1.0
1.1
0.12
2.03
u/ml
—
6
39
10
61
1.66
0.69
1.9
1.2
2.20
8.46
u/ml
—
5
26
7
42
1.68
0.68
1.3
1.1
—
—
—
0
0
10
62
1.63
0.65
2.4
2.9
7.26
6.34
pmol/l
—
10
62
20
147
1.38
0.63
2.2
3.2
0.52
0.59
%
0.52
20
147
8
53
1.52
0.59
1.1
1.8
—
—
—
0
0
11
73
1.52
0.57
1.2
1.3
—
—
—
0
0
6
37
1.63
0.56
1.3
1.3
—
—
—
0
0
9
62
1.46
0.53
1.0
1.4
—
—
—
0
0
12
83
1.46
0.52
1.5
1.6
—
—
—
0
0
9
64
1.42
0.52
1.3
1.7
—
—
—
0
0
34
281
1.23
0.49
3.7
3.1
—
—
—
0
0
8
116
0.68
0.46
1.5
1.5
—
—
—
0
0
63
559
1.15
0.44
2.8
2.9
0.54
0.70
ug/l
1.70
38
337
0
16
0.00
0.41
0.0
1.1
—
110.89
—
0
9
81
737
1.13
0.40
3.7
4.0
19.53
21.97
%
0.48
27
323
0
19
0.00
0.39
0.0
3.4
—
1.68
—
0
19
5
36
1.39
0.38
2.2
1.1
—
—
—
0
0
5
36
1.39
0.38
2.2
1.1
—
—
—
0
0
12
155
0.77
0.34
1.7
1.9
—
—
—
0
0
6
47
1.28
0.32
2.5
2.0
14.00
13.18
%
—
6
47
33
378
0.86
0.32
1.7
2.2
—
—
—
0
0
7
52
1.35
0.31
1.3
1.8
—
—
—
0
0
15
183
0.81
0.28
1.7
2.0
—
—
—
0
0
9
120
0.74
0.27
1.3
1.4
—
—
—
0
0
9
73
1.24
0.25
1.3
1.6
—
—
—
0
0
5
39
1.29
0.23
1.4
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
37
336
1.11
0.21
9.3
5.8
—
—
—
0
0
31
344
0.89
0.20
1.5
2.1
—
—
—
0
0
51
535
0.95
0.11
1.4
1.5
—
—
—
0
0
44
427
1.03
0.04
2.0
2.1
4.35
3.55
ratio
2.62
28
342
13
124
1.05
0.00
1.6
1.6
—
—
—
0
0
22
226
0.97
0.00
3.7
3.8
1.22
1.23
mmol/l
0.34
22
202
32
314
1.02
0.00
1.6
1.8
4.26
3.54
mmol/l
1.06
16
235
14
139
1.01
0.00
1.1
1.1
1.41
1.56
g/l
1.83
14
139
0
9
0.00
0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
65.20
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
9
89
1.01
-0.00
1.1
1.2
—
—
—
0
0
(3002348) Coagulation factor XII activity actual/normal in Platelet poor plasma by Coagulation assay
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
10.8
—
9.67
—
0
8
0
8
0.00
-0.00
0.0
10.8
—
5.81
—
0
8
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
6
62
0.97
-0.00
1.2
1.1
—
—
—
0
0
6
59
1.02
-0.00
1.2
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint NASH and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have NASH.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: NASH – Nonalcoholic steatohepatitis
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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