No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
139 |
4. Check minimum number of eventsNone |
139 |
5. Include endpointsNone |
139 |
6. Filter based on genotype QC (FinnGen only) |
125 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF5
- Parent code in ICD-10
- H35
- Name in latin
- Striae angioides maculae
Similar endpoints
↥List of similar endpoints to
Degenerative macular diseases, drug-induced
based on the number of shared cases.
Similar with more cases:
- Degenerative macular diseases
- Degeneration of macula and posterior pole
- Other retinal disorders
- Disorders of choroid and retina
- Diseases of the eye and adnexa
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded (not available in FinRegistry).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 125 | 54 | 71 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | 63.88 | 63.47 | 64.20 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 127
- Matched controls
- 1270
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
+∞
155.7
127
24
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
36.1
65.7
45
19
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
34.6
18.2
23
8
S01BC03
ATC
diclofenac; ophthalmic
27.7
17.2
23
10
CJB10
NOMESCO Finland
Laser discission of secondary cataract
5.7
17.0
40
95
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
23.1
16.3
23
12
H26.4
ICD-10 Finland
After-cataract
4.9
14.8
42
116
Z96.1
ICD-10 Finland
Presence of intraocular lens
3.8
11.1
48
177
H26.2
ICD-10 Finland
Complicated cataract
43.8
10.2
12
*
S01ED01
ATC
timolol; ophthalmic
8.3
10.0
22
31
H35.3
ICD-10 Finland
Degeneration of macula and posterior pole
59.7
9.8
11
*
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
5.2
9.7
22
49
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
3.2
9.5
76
402
XCW99
NOMESCO Finland
Other investigative procedure of eye
4.2
9.0
28
81
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
4.3
8.8
26
72
ZXD10
NOMESCO Finland
Scheduled procedure
3.0
8.8
66
333
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
17.9
8.8
13
8
CKD99
NOMESCO Finland
Other intraoclular operations on vitreous body and retina
+∞
8.4
8
*
H35.7
ICD-10 Finland
Separation of retinal layers
19.9
7.7
11
6
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
3.8
7.6
26
80
WX140
NOMESCO Finland
Parabulbar anesthesy
4.9
7.2
17
39
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
73.4
6.5
7
*
S01FA01
ATC
atropine; ophthalmic
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
13
32
4.40
4.04
2.2
2.6
0.21
0.36
iu/ml
—
6
17
33
166
2.33
3.90
1.8
1.8
30.27
29.17
s
0.46
33
159
60
404
1.92
3.21
2.7
2.6
82.08
78.36
nmol/l
0.43
53
343
34
187
2.12
3.20
2.0
3.1
0.81
0.83
mmol/l
0.29
34
169
54
371
1.79
2.58
3.8
3.6
—
—
—
0
0
16
77
2.23
2.07
1.4
1.6
—
—
—
0
0
68
521
1.66
2.07
8.4
7.5
1.22
1.21
mmol/l
0.29
58
441
8
28
2.98
1.90
1.8
1.5
—
—
—
0
0
8
28
2.98
1.90
1.8
1.5
—
—
—
0
0
5
12
4.29
1.84
1.6
1.4
—
—
—
0
0
7
25
2.90
1.67
1.1
1.2
—
—
—
0
0
65
514
1.54
1.60
4.6
4.6
0.00
0.00
estimate
-0.00
14
104
13
65
2.11
1.55
3.4
4.5
22.92
24.06
mmol/l
0.69
13
65
42
305
1.56
1.49
4.2
3.5
0.99
0.36
e6/l
0.73
31
236
64
510
1.51
1.49
4.6
4.6
0.00
0.00
estimate
-0.00
14
111
32
219
1.62
1.45
1.6
1.7
0.82
1.75
mg/l
1.57
25
170
27
177
1.67
1.44
4.1
3.3
0.35
1.13
e6/l
2.61
13
108
5
17
3.02
1.37
2.4
4.3
7.66
14.56
pmol/l
—
5
17
32
223
1.58
1.35
5.5
4.9
1.02
1.02
kg/l
0.47
26
147
38
276
1.54
1.34
2.5
2.2
3.13
3.12
mg/l
0.00
33
242
33
233
1.56
1.31
2.0
1.9
387.91
433.30
pmol/l
0.57
23
193
5
18
2.85
1.29
1.0
1.3
—
—
—
0
0
62
506
1.44
1.21
4.2
4.6
0.00
0.00
estimate
-0.00
15
107
43
330
1.46
1.15
2.4
1.9
1.41
1.27
mmol/l
0.66
36
262
22
147
1.60
1.10
5.0
6.4
1.04
1.05
mmol/l
0.08
22
135
20
131
1.63
1.08
2.1
4.7
216.15
252.04
u/l
1.47
20
125
7
33
2.18
1.07
1.7
1.2
—
—
—
0
0
24
165
1.56
1.07
4.4
3.5
0.14
2.68
e6/l
—
10
95
26
183
1.53
1.05
1.3
1.2
0.68
1.70
u/ml
—
5
44
22
149
1.58
1.04
2.2
1.8
—
—
—
0
0
21
142
1.57
1.00
2.2
1.9
—
—
—
0
0
6
27
2.28
0.95
1.2
1.2
—
—
—
0
0
6
28
2.20
0.93
1.2
1.2
—
—
—
0
0
51
424
1.34
0.82
2.7
2.5
—
—
—
0
0
37
293
1.37
0.81
6.4
5.0
21.55
22.70
%
0.22
22
146
90
817
1.35
0.77
5.4
5.3
4.28
4.44
mmol/l
0.68
81
734
95
871
1.36
0.75
28.1
19.9
31.64
25.42
mg/l
0.99
83
754
89
811
1.33
0.71
5.2
5.2
1.41
1.43
mmol/l
0.20
79
724
5
26
1.96
0.71
1.6
1.3
0.99
1.12
g/l
—
5
26
47
395
1.30
0.69
3.3
3.5
1630.16
1839.28
ng/l
0.18
39
327
92
847
1.31
0.65
6.5
6.0
2.45
2.57
mmol/l
0.56
82
762
17
122
1.45
0.64
3.1
4.6
5.63
5.80
kpa
0.26
17
116
14
97
1.50
0.62
7.1
6.9
12.71
11.49
mmol/l
0.20
14
89
5
30
1.69
0.62
1.8
1.4
—
—
—
0
0
5
30
1.69
0.62
1.0
1.5
—
—
—
0
0
53
459
1.27
0.60
2.6
2.3
105.29
91.30
pmol/l
0.95
24
242
6
35
1.75
0.58
1.2
1.3
—
—
—
0
0
39
327
1.28
0.57
5.1
4.0
4.82
10.02
mg/mmol
1.39
26
216
96
896
1.29
0.56
14.6
12.9
26.46
23.90
u/l
1.12
96
863
44
377
1.26
0.54
6.1
5.8
2.51
2.12
ug/l
0.45
39
330
61
547
1.22
0.49
8.8
9.3
4.55
4.33
e9/l
0.33
50
479
98
925
1.26
0.46
39.7
29.0
91.52
91.70
fl
0.16
98
911
98
925
1.26
0.46
41.3
29.4
38.76
39.31
%
0.42
98
911
87
812
1.23
0.45
8.0
7.1
40.47
40.73
mmol/mol
0.11
81
746
13
96
1.39
0.43
13.8
7.6
1.03
1.45
mmol/l
1.24
13
96
8
57
1.43
0.43
1.4
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
83
775
1.20
0.41
4.4
4.5
1.24
1.26
mmol/l
0.10
73
689
5
35
1.45
0.40
1.0
1.3
—
—
—
0
0
5
35
1.45
0.40
1.0
1.5
—
—
—
0
0
5
35
1.45
0.40
1.0
1.5
—
—
—
0
0
38
331
1.21
0.39
2.2
1.8
17.55
19.68
nmol/l
0.45
31
270
85
797
1.20
0.39
6.5
5.2
1.90
2.05
mu/l
0.54
79
700
14
107
1.35
0.39
5.7
3.6
—
—
—
0
0
20
162
1.28
0.38
1.3
1.3
96.63
38.49
iu/ml
—
6
48
24
201
1.24
0.36
2.2
2.0
—
—
—
0
0
9
72
1.27
0.26
2.0
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
2.3
—
—
—
0
0
0
11
0.00
0.21
0.0
2.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
121.17
—
0
6
0
11
0.00
0.21
0.0
2.3
—
—
—
0
0
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
32
290
1.14
0.21
3.9
4.1
0.00
0.02
estimate
0.49
12
84
0
14
0.00
0.20
0.0
2.1
—
—
—
0
0
0
14
0.00
0.20
0.0
2.1
—
—
—
0
0
34
314
1.11
0.16
2.7
2.5
57.59
56.31
u/l
0.09
29
286
6
75
0.79
0.16
1.5
1.3
—
—
—
0
0
9
82
1.10
0.15
6.9
5.2
23.38
24.68
mmol/l
—
9
77
45
427
1.08
0.12
3.2
2.8
—
—
estimate
—
0
0
10
86
1.18
0.11
2.1
3.9
57.40
58.10
ml/min/173m2
—
5
41
24
222
1.10
0.11
2.7
2.7
—
—
—
0
0
85
829
1.08
0.11
5.5
5.5
6.03
6.11
mmol/l
0.25
74
740
48
460
1.07
0.10
4.1
4.6
32.96
49.09
ng/l
0.68
40
354
5
45
1.12
0.10
1.6
1.5
23.00
37.29
u/l
—
5
36
24
224
1.09
0.09
2.0
1.8
1069.56
1164.13
nmol/l
0.19
18
165
6
56
1.07
0.09
1.5
1.7
8.54
6.15
ug/l
—
6
49
41
393
1.06
0.08
4.2
4.7
0.00
0.04
estimate
0.49
13
92
8
75
1.07
0.07
1.6
1.3
—
—
—
0
0
12
108
1.12
0.07
2.6
3.3
5.40
4.27
kpa
0.74
12
101
10
90
1.12
0.05
1.3
1.3
—
—
—
0
0
16
154
1.04
0.00
13.9
6.4
5.20
5.14
kpa
0.07
16
147
16
154
1.04
0.00
13.9
6.4
13.11
11.16
kpa
0.53
16
147
11
109
1.01
0.00
6.9
9.1
—
—
—
0
0
30
296
1.02
0.00
4.0
4.4
0.00
0.00
estimate
—
10
92
0
6
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
4.5
—
64.50
—
0
6
0
6
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
543.29
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
1.42
—
0
7
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
67.60
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
55.44
—
0
5
0
7
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.7
—
—
—
0
0
6
68
0.88
-0.00
2.0
2.5
12.38
14.88
nmol/l
—
6
63
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.4
—
—
—
0
0
Mortality – FinRegistry
↥This endpoint is excluded (not available in FinRegistry).
Relationships between endpoints
↥Index endpoint: MACULA_NAS_ADVERSE – Degenerative macular diseases, drug-induced
GWS hits: -
This endpoint is excluded (not available in FinRegistry).