spinal stenosis: Narrowing of the spinal canal.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
352 |
4. Check minimum number of eventsNone |
352 |
5. Include endpointsNone |
352 |
6. Filter based on genotype QC (FinnGen only) |
301 |
Control definitions (FinnGen only)
- Control exclude
- M13_DORSOPATHY
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M48
- Name in latin
- Vertebra collapsa non alibi classificata
Similar endpoints
↥List of similar endpoints to
Collapsed vertebra, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Spondylopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2977 | 1951 | 1011 |
| Only index persons | 2606 | 1732 | 874 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.06 | 0.03 |
| Only index persons | 0.05 | 0.06 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 76.32 | 78.64 | 71.80 |
| Only index persons | 76.04 | 78.45 | 71.27 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 301 | 191 | 110 |
| Unadjusted period prevalence (%) | 0.06 | 0.07 | 0.05 |
| Median age at first event (years) | 73.41 | 74.46 | 71.58 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 308
- Matched controls
- 3080
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M48.5
ICD-10 Finland
Collapsed vertebra, not elsewhere classified
+∞
307.7
308
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
22.3
122.9
102
67
M48.0
ICD-10 Finland
Spinal stenosis
44.5
99.8
61
17
S22.0
ICD-10 Finland
Fracture of thoracic vertebra
32.4
83.5
56
21
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
27.8
83.1
59
26
M54.5
ICD-10 Finland
Low back pain
8.7
82.1
170
383
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
8.5
75.2
136
262
S32.0
ICD-10 Finland
Fracture of lumbar vertebra
18.0
74.7
65
45
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
32.4
70.6
47
17
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
21.4
66.1
52
29
M54.9
ICD-10 Finland
Dorsalgia, unspecified
11.5
61.2
71
78
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
11.9
58.7
66
69
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
18.6
58.5
49
31
N03AX16
ATC
[U] pregabalin
7.1
58.5
119
252
N02AX02
ATC
tramadol; systemic, rectal
4.8
40.9
188
758
M80.0
ICD-10 Finland
Postmenopausal osteoporosis with pathological fracture
11.0
38.6
44
46
L03
ICPC
Low back symptom/complaint
4.8
37.9
124
382
N02AA05
ATC
oxycodone; systemic
4.7
37.7
130
417
M54.4
ICD-10 Finland
Lumbago with sciatica
6.5
35.1
65
121
N03AX12
ATC
[U] gabapentin; oral
5.7
33.3
73
159
M81.9
ICD-10 Finland
Osteoporosis, unspecified
6.9
33.1
57
98
M05BX04
ATC
denosumab; parenteral
6.2
32.5
63
122
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.1
31.4
200
964
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
177.9
31.3
32
*
M54.6
ICD-10 Finland
Pain in thoracic spine
9.6
31.2
39
46
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
3.6
27.4
178
845
M05BA04
ATC
alendronic acid; oral
4.4
27.2
84
241
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
153.4
27.1
28
*
L95
ICPC
Osteoporosis
6.9
26.3
44
73
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
55.2
25.7
30
6
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
5.9
25.2
50
98
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
58.9
23.5
27
5
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.4
22.8
123
508
N02BF02
ATC
pregabalin; oral
7.1
21.4
34
53
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
5.6
20.4
42
85
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
21.2
19.9
29
15
M54
ICD-10 Finland
Dorsalgia
5.0
19.7
47
108
N02BF01
ATC
gabapentin; oral
5.0
19.4
45
101
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.5
18.7
80
282
318
Kela drug reimbursment
Teriparatide
47.1
18.5
22
5
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.9
18.5
132
627
X59
ICD-10 Finland
Exposure to unspecified factor
3.4
18.3
82
297
L86
ICPC
Back syndrome with radiating pain
7.0
18.3
29
45
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.9
18.2
196
1153
L28
ICPC
Limited function/disability (L)
3.0
17.4
105
452
N06AX21
ATC
duloxetine; oral
4.7
17.3
43
102
C03CA01
ATC
furosemide; systemic
2.7
16.8
176
1006
M03BX02
ATC
tizanidine; oral
2.7
16.5
177
1021
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.7
16.1
137
703
M01AH02
ATC
rofecoxib; oral
3.5
16.0
65
220
N02AJ06
ATC
codeine and paracetamol; systemic
2.7
15.7
136
702
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
4.2
15.4
45
121
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.6
15.4
147
794
NE1AA
NOMESCO Finland
Pelvis X-ray examination
3.8
15.0
52
158
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.6
14.6
123
621
H05AA02
ATC
teriparatide; parenteral
38.1
14.6
18
5
JN3AD
NOMESCO Finland
Abdominal CT examination
3.4
14.6
61
210
A02BC01
ATC
omeprazole; systemic
2.6
13.6
114
571
Z01.8
ICD-10 Finland
Other specified special examinations
2.8
13.1
83
360
A06AD11
ATC
lactulose; oral
2.7
12.9
85
376
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.3
12.9
55
191
C07AB07
ATC
bisoprolol; oral
2.5
12.6
207
1392
L02
ICPC
Back symptom/complaint
3.8
12.6
42
124
AA1AD
NOMESCO Finland
CT of head and brain
2.4
12.6
129
705
ABC56
NOMESCO Finland
Decompression of lumbar spinal canal and nerve roots
135.3
12.5
13
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.0
12.5
65
253
R53
ICD-10 Finland
Malaise and fatigue
2.5
12.3
107
542
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.7
12.2
81
359
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.7
12.2
81
359
A02BC02
ATC
pantoprazole; systemic
2.6
12.1
234
1680
R52.9
ICD-10 Finland
Pain, unspecified
3.6
12.0
44
138
NA1AD
NOMESCO Finland
Cervical spine CT examination
5.1
11.9
26
55
NAG62
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, 2-3 vertebraea
+∞
11.5
11
*
N06AX11
ATC
mirtazapine; oral
2.3
11.5
126
703
R4110
NOMESCO Finland
Physiotherapy
2.4
11.5
107
556
9732/3-C42.1
ICD-O-3
Plasma cell myeloma of bone marrow
13.4
11.3
19
15
C90.0
ICD-10 Finland
Multiple myeloma
11.8
11.2
20
18
N03AE01
ATC
clonazepam; systemic
5.0
11.2
25
54
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.9
11.1
58
226
N39.4
ICD-10 Finland
Other specified urinary incontinence
3.1
10.9
50
181
S22.3
ICD-10 Finland
Fracture of rib
3.9
10.8
34
96
R07.4
ICD-10 Finland
Chest pain, unspecified
2.3
10.8
107
569
M43.1
ICD-10 Finland
Spondylolisthesis
22.4
10.8
15
7
N06AX16
ATC
venlafaxine; oral
3.2
10.8
46
159
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
62.2
10.7
12
*
N02BE01
ATC
paracetamol; systemic, rectal
4.1
10.7
286
2339
B01AB05
ATC
enoxaparin; parenteral
2.3
10.6
125
714
A02BC05
ATC
esomeprazole; systemic
2.2
10.6
135
796
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
12.7
10.5
18
15
I48
ICD-10 Finland
Atrial fibrillation and flutter
2.3
10.4
118
663
A07AA02
ATC
nystatin; oral
3.8
10.4
33
94
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
4.5
10.3
26
62
ZXD05
NOMESCO Finland
Urgent procedure
2.3
10.0
107
585
H02AB06
ATC
prednisolone; systemic
2.2
10.0
164
1063
Z3231
NOMESCO Finland
Registered nurse
2.3
9.9
102
548
A01
ICPC
Pain general/multiple sites
3.2
9.9
43
150
UJF32
NOMESCO Finland
Coloscopy
2.3
9.9
99
526
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
9.8
82
403
M03BC01
ATC
orphenadrine (citrate); systemic
2.7
9.7
57
235
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.5
9.7
71
327
K59.09
ICD-10 Finland
Constipation, unspecified
3.7
9.6
32
94
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
3.8
9.5
30
85
M80.8
ICD-10 Finland
Other osteoporosis with pathological fracture
31.1
9.5
12
*
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
31.1
9.5
12
*
D07AC01
ATC
betamethasone; topical
2.2
9.4
125
741
X58
ICD-10 Finland
Exposure to other specified factors
2.8
9.4
51
202
R50.9
ICD-10 Finland
Fever, unspecified
2.6
9.3
60
260
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.6
9.3
63
280
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
4.3
9.2
24
59
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.1
9.2
40
140
153
Kela drug reimbursment
Lenalidomid
16.2
9.1
14
9
A28
ICPC
Limited function/disability NOS
2.2
9.1
97
527
M01AH05
ATC
etoricoxib; oral
2.1
8.9
169
1139
M54.8
ICD-10 Finland
Other dorsalgia
8.0
8.8
19
25
Z3226
NOMESCO Finland
Physiotherapist
2.4
8.8
68
321
M51.8
ICD-10 Finland
Other specified intervertebral disc disorders
51.5
8.7
10
*
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
8.6
8.7
18
22
R52.2
ICD-10 Finland
Other chronic pain
6.7
8.6
21
33
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
16.9
8.6
13
8
N04BC05
ATC
pramipexole; oral
3.2
8.6
36
123
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
20.7
8.5
12
6
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
3.2
8.5
35
118
N05BA04
ATC
oxazepam; oral
2.2
8.5
97
539
SPAT1229
SPAT
Assessment of need for aid
3.1
8.5
38
135
B01AF02
ATC
apixaban; oral
2.4
8.5
68
326
A02BC03
ATC
lansoprazole; oral
2.1
8.3
103
590
L04AX04
ATC
lenalidomide; oral
15.0
8.3
13
9
329
Kela drug reimbursment
Lenalidomide
34.3
8.1
10
*
207
Kela drug reimbursment
Chronic arrhythmias
2.2
8.1
82
434
M05BA07
ATC
risedronic acid; oral
3.8
8.0
25
70
M79.6
ICD-10 Finland
Pain in limb
2.0
8.0
130
820
SPAT1255
SPAT
Intravenous administration of medicine
3.3
8.0
31
101
NF1AA
NOMESCO Finland
Hip X-ray examination
2.8
7.8
43
171
A02BA02
ATC
ranitidine; systemic
2.2
7.8
82
439
Z2446
NOMESCO Finland
Social worker
3.3
7.8
30
97
J01DB01
ATC
cefalexin; oral
2.3
7.8
248
1982
N30.0
ICD-10 Finland
Acute cystitis
2.3
7.7
68
338
A06AC01
ATC
ispaghula (psylla seeds); oral
2.1
7.7
98
565
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.2
7.7
80
427
NA2CG
NOMESCO Finland
Thoracal spine extensive MRI examination with high intensity magnet
18.9
7.7
11
6
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.9
7.7
38
143
M47.82
ICD-10 Finland
Other spondylosis, cervical region
12.3
7.6
13
11
NA2AD
NOMESCO Finland
Thoracic spine CT examination
25.7
7.6
10
*
ZXD10
NOMESCO Finland
Scheduled procedure
2.0
7.6
128
815
ZXA05
NOMESCO Finland
Left side
2.1
7.5
94
537
A97
ICPC
No disease
2.2
7.5
74
386
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
82.0
7.4
8
*
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
82.0
7.4
8
*
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
13.8
7.4
12
9
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.5
7.4
50
220
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
3.7
7.4
24
69
ZXE20
NOMESCO Finland
More than three and less than five hours
2.5
7.4
53
240
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.2
7.4
78
417
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
3.0
7.4
35
128
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.9
7.4
36
134
WX892
NOMESCO Finland
Monitored bed care
3.0
7.4
33
117
ABC16
NOMESCO Finland
Microsurgical excision of lumbar intervertebral disc displacement
+∞
7.3
7
*
WW402
NOMESCO Finland
Leucoferesis
+∞
7.3
7
*
R5110, ,
SPAT
2.7
7.3
41
165
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.3
7.1
64
321
J01EA01
ATC
trimethoprim; systemic
2.0
7.1
108
662
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
2.5
7.0
46
200
W19
ICD-10 Finland
Unspecified fall
2.5
6.9
45
195
XF400
NOMESCO Finland
ECG with 12 standard connections
2.2
6.8
64
326
UKC02
NOMESCO Finland
Cystoscopy
2.3
6.8
57
277
M47.9
ICD-10 Finland
Spondylosis, unspecified
41.0
6.8
8
*
N02AC04
ATC
dextropropoxyphene; oral
3.9
6.8
20
54
L84
ICPC
Back syndrome without radiat pain
4.2
6.7
18
45
NA3DG
NOMESCO Finland
Lumbar spine very extensive MRI examination with high intensity magnet
23.1
6.7
9
*
M01AC06
ATC
meloxicam; systemic, rectal
1.9
6.7
112
705
J05AB11
ATC
valaciclovir; oral
2.4
6.7
51
238
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.0
6.6
19
50
Z76.8
ICD-10 Finland
Persons encountering health services in other specified circumstances
4.0
6.6
19
50
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.0
6.6
30
107
D64.9
ICD-10 Finland
Anaemia, unspecified
2.3
6.6
56
273
J01FF01
ATC
clindamycin; systemic
2.0
6.6
87
504
NE1AD
NOMESCO Finland
Pelvis and hip bones CT examination
5.6
6.6
18
34
M81.0
ICD-10 Finland
Postmenopausal osteoporosis
3.7
6.6
21
60
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
5.9
6.6
17
30
A46
ICD-10 Finland
Erysipelas
2.2
6.5
61
311
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.3
6.4
51
242
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.6
6.4
38
157
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.1
6.4
69
371
N05BA12
ATC
alprazolam; oral
2.7
6.4
36
145
G04CA02
ATC
tamsulosin; oral
2.1
6.4
75
417
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.2
6.3
58
292
SPAT1260
SPAT
Consultation of another employee
2.2
6.3
63
328
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.2
6.3
62
321
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.9
6.3
106
666
NAG66
NOMESCO Finland
Posterior interbody fusion of lumbar spine, 2 vertebrae
+∞
6.3
6
*
NAG63
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, more than 3 vertebraea
+∞
6.3
6
*
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.5
6.3
22
67
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.9
6.3
95
577
R30.0
ICD-10 Finland
Dysuria
4.1
6.3
17
43
N05AA02
ATC
levomepromazine; systemic
4.1
6.3
17
43
Z02.7
ICD-10 Finland
Issue of medical certificate
2.9
6.2
29
105
B01AA03
ATC
warfarin; systemic
2.0
6.2
91
545
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.8
6.2
31
117
R06AE07
ATC
cetirizine; oral
1.9
6.2
121
797
N30.9
ICD-10 Finland
Cystitis, unspecified
2.7
6.2
33
129
N05BA01
ATC
diazepam; systemic, rectal
2.3
6.2
49
232
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
4.3
6.2
16
39
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
4.3
6.2
16
39
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
4.3
6.2
16
39
A04AA01
ATC
ondansetron; systemic, rectal
2.7
6.1
35
142
M54.2
ICD-10 Finland
Cervicalgia
3.5
6.1
21
63
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.5
6.1
21
63
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.1
6.0
70
386
R35
ICD-10 Finland
Polyuria
3.3
6.0
23
74
SCA01
NOMESCO Finland
Preventive oral health care, short
2.0
6.0
75
425
M02AA07
ATC
piroxicam; topical
1.8
6.0
122
812
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
153
723
3.22
22.58
5.4
3.3
0.40
0.51
e6/l
0.39
117
553
178
940
3.12
21.27
5.7
3.3
—
—
—
0
0
45
94
5.44
21.10
15.1
3.7
53.44
62.78
mg/l
0.09
38
77
45
94
5.44
21.10
14.9
3.6
68.25
72.91
mg/l
0.05
38
77
43
88
5.52
20.60
14.2
3.3
52.06
4.32
ratio
0.47
26
51
165
863
2.96
19.59
5.8
3.3
29.64
126.06
e6/l
0.72
126
678
204
1200
3.07
19.46
9.4
4.5
33.76
34.60
g/l
1.28
184
1101
113
484
3.11
19.18
2.6
1.9
—
—
—
0
0
100
402
3.20
18.89
5.5
3.0
4.10
3.06
e6/l
0.27
49
212
144
716
2.90
18.53
3.0
2.3
2.95
3.09
mg/l
0.27
118
597
100
419
3.05
17.41
3.9
2.3
20.66
21.39
%
0.22
93
381
108
477
2.95
17.06
4.0
2.3
11.51
11.90
umol/l
0.21
101
432
100
424
3.01
16.99
4.8
2.9
0.92
1.48
e6/l
0.99
50
232
92
373
3.09
16.91
2.4
1.8
—
—
—
0
0
191
1139
2.78
16.78
3.5
2.3
82.35
79.36
nmol/l
0.72
176
977
219
1404
2.94
16.68
16.1
6.6
1.20
1.21
mmol/l
1.24
189
1175
88
351
3.11
16.61
2.3
1.9
—
—
—
0
0
103
449
2.94
16.60
3.9
2.3
2.20
2.26
g/l
0.43
97
404
209
1326
2.79
15.90
10.6
6.6
10.89
12.47
umol/l
1.54
195
1255
166
942
2.65
15.80
4.6
3.4
2.33
2.36
mmol/l
2.62
156
838
55
178
3.54
14.44
6.3
3.3
10.88
10.83
g/l
0.02
48
161
61
211
3.36
14.44
2.0
1.5
—
—
—
0
0
205
1331
2.62
14.16
6.7
4.3
29.85
0.00
estimate
0.49
46
314
195
1241
2.56
13.98
16.4
6.0
1.20
1.21
mmol/l
2.57
184
1111
202
1320
2.54
13.48
6.6
4.3
0.00
0.00
estimate
-0.00
42
298
98
462
2.64
13.18
1.4
1.3
2.04
0.95
u/ml
0.69
22
110
136
752
2.45
13.01
3.5
2.4
50.64
66.15
u/l
1.67
123
687
171
1048
2.42
12.97
4.8
2.8
137.46
138.87
ug/l
0.03
156
942
164
987
2.42
12.96
4.7
3.4
2158.12
1877.11
ng/l
0.23
142
850
55
191
3.29
12.87
2.1
1.7
—
—
—
0
0
202
1343
2.46
12.62
29.7
17.5
1.40
1.35
inr
0.48
177
1122
201
1341
2.44
12.34
6.8
4.3
0.00
0.00
estimate
0.50
44
293
68
274
2.90
12.29
4.7
2.0
7.25
10.11
umol/l
0.98
56
239
203
1371
2.41
11.96
18.7
9.3
4.46
4.25
e9/l
0.53
174
1200
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
34
90
4.12
11.82
4.6
2.3
0.36
0.38
iu/ml
0.08
21
53
251
1882
2.80
11.60
16.9
7.8
83.94
81.22
u/l
0.36
239
1741
59
228
2.96
11.45
4.4
3.2
77.77
82.19
ng/l
0.19
49
190
58
223
2.97
11.36
2.6
2.0
33.00
34.41
u/l
0.10
47
188
76
341
2.63
11.10
11.0
6.6
1.53
1.31
mmol/l
0.14
68
284
67
283
2.75
11.01
6.2
3.1
3.17
2.18
mmol/l
1.40
62
240
169
1098
2.19
10.34
3.9
2.7
—
—
estimate
—
0
0
111
614
2.26
10.09
3.7
2.7
5.18
6.02
e6/l
0.44
105
566
182
1231
2.17
9.89
2.8
2.2
92.82
95.85
pmol/l
0.32
99
606
140
857
2.16
9.83
2.2
1.7
18.91
20.01
nmol/l
0.40
119
689
237
1791
2.40
9.68
6.9
4.2
19.64
15.14
mm/h
2.32
220
1610
104
571
2.24
9.54
4.4
3.0
2.47
2.47
mmol/l
0.09
96
515
31
90
3.72
9.47
15.7
1.8
0.00
0.00
g/l
-0.00
31
76
165
1106
2.06
8.82
2.8
2.5
—
—
—
0
0
26
71
3.91
8.65
1.4
1.7
—
—
—
0
0
131
815
2.06
8.51
3.0
2.0
237.10
292.98
u/l
0.17
120
767
125
767
2.06
8.41
4.4
2.9
33.68
36.20
u/l
0.19
115
724
160
1074
2.02
8.38
6.8
4.1
46.15
71.84
ng/l
0.38
132
840
53
227
2.61
8.36
2.5
2.1
344.57
421.76
nmol/l
1.19
47
205
105
606
2.11
8.31
3.7
2.5
—
—
—
0
0
36
131
2.98
7.69
2.0
1.8
0.28
3.82
ug/l
0.98
28
115
191
1401
1.96
7.37
4.8
3.0
68.86
52.89
u/l
1.26
175
1275
97
569
2.03
7.19
2.2
1.8
1112.38
1080.74
nmol/l
0.12
72
416
18
43
4.38
7.11
1.9
1.9
7.97
8.14
pmol/l
0.03
18
43
19
49
4.07
6.82
1.4
1.4
—
—
—
0
0
19
49
4.07
6.82
1.4
1.4
—
—
—
0
0
202
1537
1.91
6.68
12.0
4.8
6.87
6.80
mmol/l
0.16
194
1454
19
50
3.98
6.64
1.5
1.3
—
—
—
0
0
39
163
2.59
6.43
2.3
1.6
1.81
1.56
%
0.40
33
141
27
93
3.09
6.33
1.7
1.3
—
—
—
0
0
63
332
2.13
6.13
1.4
1.2
41.40
15.75
u/ml
0.62
19
114
22
69
3.36
6.00
5.5
4.0
0.81
1.68
index
0.61
16
38
27
97
2.95
5.90
4.2
3.6
0.72
0.77
nmol/l
0.18
22
79
33
133
2.66
5.84
2.9
4.1
1.62
2.59
mmol/l
0.56
24
106
90
549
1.90
5.80
6.3
3.8
89.82
360.23
ng/l
2.22
79
471
68
377
2.03
5.77
1.5
1.2
32.01
35.77
iu/ml
0.12
25
126
35
152
2.47
5.33
2.2
1.3
—
—
—
0
0
21
69
3.19
5.33
1.7
1.5
—
—
—
0
0
83
506
1.88
5.30
3.3
1.7
1.65
1.44
mg/l
0.22
73
408
13
22
6.12
5.28
2.5
3.3
577.23
885.32
mg
0.34
13
22
18
54
3.48
5.25
1.6
1.6
—
—
—
0
0
49
249
2.15
5.20
2.3
2.4
5.65
6.53
ug/l
0.21
39
215
267
2311
2.17
5.17
45.9
17.4
27.22
25.74
mg/l
0.37
252
1972
17
50
3.54
5.10
1.9
2.0
—
—
—
0
0
95
621
1.77
4.78
4.5
3.0
344.74
358.15
umol/l
0.45
85
540
21
76
2.89
4.55
2.1
1.7
—
—
—
0
0
17
55
3.21
4.43
1.7
1.6
—
—
—
0
0
7
6
11.90
4.29
2.1
1.0
100.14
112.33
%
—
7
6
20
73
2.86
4.27
1.7
1.3
—
—
—
0
0
18
62
3.02
4.24
1.7
1.6
—
—
—
0
0
19
68
2.91
4.20
1.7
1.3
—
—
—
0
0
15
47
3.30
4.11
1.8
1.6
—
—
—
0
0
24
99
2.54
4.08
3.3
3.1
—
—
—
0
0
12
28
4.42
3.86
1.3
1.8
—
—
—
0
0
135
1016
1.59
3.78
7.4
4.4
0.11
0.05
estimate
0.39
35
244
11
24
4.71
3.78
1.7
1.4
87.32
88.56
%
0.18
11
24
11
24
4.71
3.78
1.8
1.7
—
—
—
0
0
19
73
2.71
3.71
2.0
1.7
—
—
—
0
0
46
259
1.91
3.69
2.9
1.9
0.21
0.20
g/l
0.56
39
240
9
16
5.76
3.68
1.4
1.3
—
—
—
0
0
86
590
1.63
3.49
6.9
4.4
1.01
1.02
kg/l
1.53
68
399
11
27
4.19
3.43
1.4
1.2
—
—
—
0
0
270
2433
1.89
3.39
52.5
21.8
3.98
3.99
mmol/l
0.34
261
2364
270
2433
1.89
3.39
51.1
21.6
138.56
139.50
mmol/l
4.98
261
2367
101
727
1.58
3.35
6.2
3.9
0.03
0.00
estimate
0.38
36
223
12
33
3.74
3.33
1.5
1.9
—
—
—
0
0
8
15
5.44
3.21
1.3
1.8
—
—
—
0
0
8
15
5.44
3.21
1.3
1.8
—
—
—
0
0
17
67
2.63
3.18
1.5
1.2
—
—
—
0
0
11
30
3.76
3.12
1.4
1.2
—
—
—
0
0
17
68
2.59
3.10
1.5
1.2
—
—
—
0
0
7
12
5.94
3.03
2.3
1.2
—
—
—
0
0
268
2434
1.78
2.94
23.8
12.1
22.03
23.73
u/l
1.56
256
2328
271
2474
1.79
2.85
54.1
23.8
80.35
80.08
umol/l
0.04
263
2427
14
53
2.72
2.83
1.3
1.7
—
—
—
0
0
8
18
4.53
2.81
2.9
1.4
—
—
—
0
0
5
6
8.44
2.76
1.2
1.3
—
—
—
0
0
11
34
3.32
2.75
1.5
1.7
—
—
—
0
0
47
293
1.71
2.71
5.8
3.4
—
—
—
0
0
10
29
3.53
2.71
3.0
1.2
4.80
9.22
u/ml
—
5
9
249
2238
1.59
2.61
41.0
18.0
72.76
72.24
ml/min/173m2
0.14
235
2073
7
15
4.75
2.61
3.3
1.7
0.37
0.39
e9/l
—
7
15
11
36
3.13
2.59
1.6
1.4
—
—
—
0
0
12
42
2.93
2.58
1.5
1.3
—
—
—
0
0
7
16
4.45
2.49
1.7
1.9
—
—
—
0
0
209
1820
1.46
2.47
5.6
4.3
15.64
15.21
pmol/l
1.45
196
1597
271
2496
1.71
2.47
61.8
26.5
92.79
91.51
fl
3.46
263
2451
271
2498
1.71
2.43
62.5
26.8
125.97
131.23
g/l
6.75
265
2453
271
2498
1.71
2.43
61.5
26.6
246.21
243.66
e9/l
0.22
260
2429
271
2498
1.71
2.43
63.9
26.9
37.45
39.13
%
3.85
263
2451
271
2498
1.71
2.43
61.9
26.6
4.18
4.36
e12/l
6.01
260
2419
41
254
1.71
2.43
1.5
1.4
—
—
—
0
0
15
64
2.41
2.43
1.5
1.3
246.22
289.94
ug/g
—
9
41
7
18
3.95
2.26
1.7
1.8
—
—
—
0
0
5
9
5.63
2.22
1.0
1.0
—
—
—
0
0
55
378
1.55
2.17
3.3
3.1
0.86
0.84
ug/l
0.06
38
264
9
30
3.06
2.16
2.1
1.9
—
—
—
0
0
7
19
3.74
2.16
1.7
1.7
—
—
—
0
0
244
2216
1.49
2.11
7.8
7.1
41.16
40.39
mmol/mol
0.48
224
2016
18
91
2.04
1.99
1.4
1.3
—
—
—
0
0
11
45
2.50
1.95
1.2
1.1
—
2.00
—
0
5
8
27
3.01
1.95
2.5
1.5
—
—
—
0
0
8
27
3.01
1.95
2.5
1.5
—
—
—
0
0
5
11
4.60
1.95
4.6
3.3
—
—
—
0
0
250
2293
1.48
1.94
5.9
6.1
2.39
2.55
mmol/l
2.07
223
2053
6
16
3.80
1.94
1.3
1.0
—
—
—
0
0
80
611
1.42
1.87
1.9
1.8
422.44
56965096.19
pmol/l
1.18
62
481
8
28
2.91
1.87
2.5
1.5
—
—
—
0
0
6
17
3.58
1.84
2.2
1.7
13.28
14.32
umol/l
—
6
12
239
2183
1.42
1.81
6.9
5.4
1.91
2.05
mu/l
0.94
224
1928
9
35
2.62
1.81
1.9
1.8
3.31
110.76
u/ml
—
9
35
8
29
2.80
1.80
2.1
2.0
—
—
—
0
0
8
29
2.80
1.80
2.5
1.5
—
—
—
0
0
8
29
2.80
1.80
2.4
1.5
—
—
—
0
0
8
29
2.80
1.80
2.5
1.5
—
—
—
0
0
9
36
2.54
1.75
1.1
1.1
—
—
—
0
0
242
2222
1.42
1.72
5.1
5.1
1.47
1.49
mmol/l
0.35
216
1973
29
181
1.66
1.71
2.2
3.2
53.64
53.86
ml/min/173m2
0.01
11
84
36
238
1.58
1.69
4.1
2.4
0.34
0.76
e6/l
0.53
36
231
8
31
2.62
1.67
1.1
2.0
127.75
215.77
pmol/l
—
8
26
243
2241
1.40
1.62
5.3
5.2
4.32
4.49
mmol/l
1.62
220
2009
6
20
3.04
1.59
2.0
2.0
—
—
—
0
0
18
100
1.85
1.56
3.0
2.0
—
—
—
0
0
5
15
3.37
1.53
1.0
1.1
—
—
—
0
0
232
2134
1.35
1.49
4.4
4.4
1.29
1.25
mmol/l
0.27
199
1874
95
774
1.33
1.47
6.9
4.2
0.00
0.01
estimate
0.50
39
271
5
17
2.97
1.36
3.2
1.4
—
—
—
0
0
5
17
2.97
1.36
3.2
1.4
—
—
—
0
0
6
24
2.53
1.31
1.5
1.0
—
—
—
0
0
13
69
1.92
1.30
1.2
1.3
—
—
—
0
0
8
35
2.32
1.28
4.6
4.1
—
—
—
0
0
16
92
1.78
1.27
2.4
1.8
—
—
—
0
0
81
658
1.31
1.27
6.3
5.4
3.92
2.79
ug/l
0.61
69
585
244
2281
1.34
1.25
5.7
5.5
6.10
6.09
mmol/l
0.04
224
2016
5
19
2.66
1.22
7.4
2.9
0.20
0.89
index
—
5
19
66
525
1.33
1.20
4.5
4.5
21.75
22.37
%
0.12
33
266
6
26
2.33
1.19
2.2
1.9
—
—
—
0
0
6
26
2.33
1.19
2.2
1.9
—
—
—
0
0
6
26
2.33
1.19
2.2
1.9
—
—
—
0
0
24
174
1.41
0.79
1.6
1.4
—
—
—
0
0
8
48
1.68
0.79
1.1
1.2
—
14.18
—
0
6
15
99
1.54
0.77
1.1
1.1
—
—
—
0
0
5
24
2.10
0.75
1.2
1.7
—
—
—
0
0
9
55
1.66
0.74
1.0
1.4
—
—
—
0
0
39
313
1.28
0.69
16.5
7.7
—
—
—
0
0
16
112
1.45
0.65
2.2
1.3
180.10
307.41
u/ml
0.53
16
100
6
35
1.73
0.58
1.3
1.3
1.36
0.89
g/l
—
6
35
6
36
1.68
0.57
3.7
1.6
12.00
10.42
mmol/l
—
6
36
9
63
1.44
0.52
1.6
1.3
—
—
—
0
0
27
333
0.79
0.51
5.1
5.0
34.05
33.08
%
0.21
19
191
83
907
0.88
0.41
4.2
4.1
7.28
8.24
mg/mmol
0.13
58
560
5
34
1.48
0.40
3.8
1.7
—
—
—
0
0
5
34
1.48
0.40
1.6
1.9
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
10
74
1.36
0.32
2.0
1.9
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
8
68
1.18
0.16
2.1
1.5
—
—
—
0
0
10
84
1.20
0.14
2.2
1.9
—
—
—
0
0
28
263
1.07
0.08
1.4
1.4
—
—
—
0
0
92
938
0.97
0.05
1.9
1.9
1.34
1.32
mmol/l
0.11
82
743
13
137
0.95
0.01
1.3
1.2
32.77
148.35
u/ml
—
6
46
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
6
67
0.89
-0.00
1.3
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
1343.38
—
0
8
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
53.87
—
0
9
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_VERTEBCOLLAPSE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_VERTEBCOLLAPSE | 1.885 [1.61, 2.21] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.355 |
During the follow-up period (1.1.1998 — 31.12.2019), 934 out of 1714 females with M13_VERTEBCOLLAPSE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_VERTEBCOLLAPSE | 2.57 [1.93, 3.42] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 507 out of 886 males with M13_VERTEBCOLLAPSE died.
Mortality risk
Mortality risk for people of age
years, who have M13_VERTEBCOLLAPSE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.216% | 0.475% |
| 5 | 1.281% | 3.061% |
| 10 | 3.045% | 7.447% |
| 15 | 5.762% | 13.539% |
| 20 | 9.692% | 22.336% |
Relationships between endpoints
↥Index endpoint: M13_VERTEBCOLLAPSE – Collapsed vertebra, not elsewhere classified
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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