spinal stenosis: Narrowing of the spinal canal.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519870 |
1. Apply sex-specific ruleNone |
519870 |
2. Check conditionsNone |
519870 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
308 |
4. Check minimum number of eventsNone |
308 |
5. Include endpointsNone |
308 |
6. Filter based on genotype QC (FinnGen only) |
301 |
Control definitions (FinnGen only)
- Control exclude
- M13_DORSOPATHY
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M48
- Name in latin
- Vertebra collapsa non alibi classificata
Similar endpoints
↥List of similar endpoints to
Collapsed vertebra, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Spondylopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2977 | 1951 | 1011 |
| Only index persons | 2606 | 1732 | 874 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.06 | 0.03 |
| Only index persons | 0.05 | 0.06 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 76.32 | 78.64 | 71.80 |
| Only index persons | 76.04 | 78.45 | 71.27 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 301 | 191 | 110 |
| Unadjusted period prevalence (%) | 0.06 | 0.07 | 0.05 |
| Median age at first event (years) | 73.41 | 74.46 | 71.58 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 308
- Matched controls
- 3080
TimeCodeWAS
↥TODO / Current known limitations:
- Only showing the top 500 codes, because showing all (sometimes 20k) makes the page too slow.
- Legend / how to read the glyphs.
- Proper column names.
- Show details (e.g. Fisher or Chi-square test, N cases and N controls) when clicking on a row.
- Explanation on the underlying data / how the TimeCodeWAS is done (e.g. matched cases / controls, eligibility).
- Download CSV not working.
- No filters and sorters.
- Limited amount of endpoints with TimeCodeWAS data.
- Cross-links to Risteys lab test pages for lab test codes.
M48.5 (45582162)
NA3AA (2001307026)
50373000 (4177340)
60621009 (4245997)
M54.9 (45538791)
M48.0 (45557888)
GD1AA (2001303617)
NA2AA (2001307007)
R4110 (2001310233)
SMOKING-2-2-0 (2002330110)
N02AA05 (21604260)
30391-7 (3002582)
14749-6 (3013826)
19072-8 (3016431)
30405-5 (3018095)
50554-5 (3029287)
51486-9 (3029879)
51483-6 (3030467)
51480-2 (3031040)
5894-1 (3033658)
34487-9 (3044938)
87829-8 (36304419)
14 (38004459)
20 (38004465)
25 (38004468)
M54.4 (45553205)
M80.9 (45553292)
R10.4 (45568113)
X59 (45756412)
OMOP4822462 (581458)
IP (9201)
ER (9203)
N02BF01 (955005)
N02AX02 (21604298)
N02BF02 (955152)
N02AE01 (21604287)
82 (38004501)
M54.5 (45553207)
1988-5 (3020460)
OP (9202)
L03 (2002000628)
57778-3 (40760888)
N06AX21 (21604749)
N02AJ06 (1123647)
2601-3 (3012095)
W01 (45756243)
14804-9 (3022250)
2753-2 (3018418)
N02AB03 (21604272)
H05BA01 (21602787)
36916-5 (3034860)
33944-0 (3047169)
M81.9 (45591963)
30385-9 (3002385)
B01AB05 (21600976)
600-7 (3023368)
2951-2 (3019550)
15189-4 (3007778)
2823-3 (3023103)
1995-0 (3021347)
32731-2 (3043747)
2868-8 (3005229)
32730-4 (3043723)
34714-6 (3032080)
OMOP4822458 (581477)
69738-3 (42870588)
14879-1 (3003458)
2874-6 (3023465)
51435-6 (3029713)
20454-5 (3014051)
1 (38004446)
M05BA04 (21604152)
M80.0 (45572553)
28540-3 (3003338)
SPAT1223 (2001700324)
68438-1 (40771025)
24351-9 (3004588)
29265-6 (3020059)
93 (38004510)
ERIP (262)
26464-8 (3010813)
30428-7 (3024731)
26453-1 (3026361)
28539-5 (3035941)
718-7 (3000963)
20570-8 (3009542)
26515-7 (3007461)
14682-9 (3020564)
21 (8717)
2 (38004447)
62238-1 (40764999)
630-4 (3026008)
11 (38004456)
2885-2 (3020630)
L28 (2002000647)
26485-3 (3019069)
26450-7 (3006504)
30180-4 (3022096)
26511-6 (3018010)
26474-7 (3019198)
26478-8 (3002030)
26484-6 (3001604)
2514-8 (3035350)
29 (38004472)
26444-0 (3006315)
22 (8756)
14631-6 (3006140)
2000-8 (3015377)
26449-9 (3013115)
5802-4 (3021601)
1751-7 (3024561)
46 (38004485)
25428-4 (3009261)
N02AA55 (21604265)
A12AA20 (21600872)
H02AB06 (21602734)
A07EA01 (21600653)
L01BA01 (21601423)
L04AX03 (21603929)
6768-6 (3035995)
M03BX02 (21604116)
890-4 (3001079)
34531-4 (3044640)
13 (38004458)
2276-4 (3001122)
58410-2 (40761511)
751-8 (3013650)
OMOP4822461 (32036)
251B00000X (38004193)
N02BE01 (21604344)
715-3 (3021589)
A02BC05 (21600100)
A02BC02 (21600097)
4537-7 (3013707)
M05BX04 (21604169)
1742-6 (3006923)
J01FF01 (21602985)
30248-9 (3015399)
106 (44777669)
OMOP5117446 (33004)
24357-6 (3037467)
66 (38004491)
R02AX02 (1588667)
M01AE01 (21603967)
OMOP4822459 (581476)
C03CA01 (21601518)
GD1QA (2001303648)
LabWAS
↥Mortality – FinRegistry
↥Association
Association between endpoint M13_VERTEBCOLLAPSE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_VERTEBCOLLAPSE | 1.885 [1.61, 2.21] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.355 |
During the follow-up period (1.1.1998 — 31.12.2019), 934 out of 1714 females with M13_VERTEBCOLLAPSE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_VERTEBCOLLAPSE | 2.57 [1.93, 3.42] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 507 out of 886 males with M13_VERTEBCOLLAPSE died.
Mortality risk
Mortality risk for people of age
years, who have M13_VERTEBCOLLAPSE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.216% | 0.475% |
| 5 | 1.281% | 3.061% |
| 10 | 3.045% | 7.447% |
| 15 | 5.762% | 13.539% |
| 20 | 9.692% | 22.336% |
Relationships between endpoints
↥Index endpoint: M13_VERTEBCOLLAPSE – Collapsed vertebra, not elsewhere classified
GWS hits: 2