Valgus deformity, not elsewhere classified

M13_VALGUS

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M21.0
  • Hospital discharge: ICD-9 7360A|7363A|7364A
  • Hospital discharge: ICD-8 73802|73800
  • Cause of death: ICD-10 M21.0
  • Cause of death: ICD-9 7360A|7363A|7364A
  • Cause of death: ICD-8 73802|73800

2 out of 7 registries used, show all original rules.

321

4. Check minimum number of events

None

321

5. Include endpoints

None

321

6. Filter based on genotype QC (FinnGen only)

291

Control definitions (FinnGen only)

Control exclude
M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M21
Name in latin
Deformitas membri valga non alibi classificata

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2937 1838 1089
Only index persons 2579 1613 966
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.03
Only index persons 0.05 0.06 0.04
Median age at first event (years)
Whole population 35.31 47.23 14.96
Only index persons 34.02 45.33 15.13

-FinnGen-

Key figures

All Female Male
Number of individuals 291 207 84
Unadjusted period prevalence (%) 0.06 0.07 0.04
Median age at first event (years) 42.42 48.06 28.53

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
301
Matched controls
3010
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M21.0
ICD-10 Finland
Valgus deformity, not elsewhere classified
10771.2
298.6
236
*
M20.1
ICD-10 Finland
Hallux valgus (acquired)
76.3
165.2
91
17
M17.1
ICD-10 Finland
Other primary gonarthrosis
28.5
120.8
88
43
M19.0
ICD-10 Finland
Primary arthrosis of other joints
34.2
84.9
56
20
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
16.6
76.9
71
55
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
23.6
70.2
53
27
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
+∞
57.1
53
*
M20.4
ICD-10 Finland
Other hammer toe(s) (acquired)
134.0
52.8
55
5
NHK30
NOMESCO Finland
Osteotomy or rotation osteotomy of first metatarsal or tarsal bone
+∞
46.0
43
*
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
10.6
43.8
52
58
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
+∞
42.7
40
*
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
16.4
39.7
35
24
M21.4
ICD-10 Finland
Flat foot [pes planus] (acquired)
65.8
39.6
45
8
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
+∞
34.0
32
*
M25.5
ICD-10 Finland
Pain in joint
4.2
30.6
116
391
WX320
NOMESCO Finland
Spinalanesthesy
4.8
30.4
87
237
NHK40
NOMESCO Finland
Osteotomy or rotation osteotomy of II-V metatarsal or tarsal bone
+∞
29.7
28
*
L15
ICPC
Knee symptom/complaint
4.2
29.4
105
338
N03AX12
ATC
[U] gabapentin; oral
5.0
27.3
69
169
M01AX05
ATC
glucosamine; oral
5.0
25.8
65
158
73802
ICD-8 Finland
Other deformities, Genu valgum
+∞
25.4
24
*
N02AX02
ATC
tramadol; systemic, rectal
3.4
24.3
144
637
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
45.7
24.1
29
7
M13.9
ICD-10 Finland
Arthritis, unspecified
24.5
23.6
33
15
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
21.1
23.2
34
18
ZXA00
NOMESCO Finland
Right side
3.6
22.2
96
345
NHG77
NOMESCO Finland
Arthroplasty of interphalangeal tarsal joint(s)
+∞
22.2
21
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
7.8
22.1
32
45
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.2
21.9
142
654
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
6.1
21.4
40
74
NH3FA
NOMESCO Finland
Weight-bearing X-ray of foot
64.9
21.2
24
*
ZXA05
NOMESCO Finland
Left side
3.6
20.8
88
310
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
20.7
20.4
30
16
M79.6
ICD-10 Finland
Pain in limb
3.0
19.4
154
781
N02AJ06
ATC
codeine and paracetamol; systemic
3.0
19.2
143
700
NGU20
NOMESCO Finland
Removal of internal fixation device from knee or lower leg
37.1
19.2
24
7
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
6.5
19.1
33
56
NHG26
NOMESCO Finland
Fusion between bones of ankle or ankle and foot
202.1
18.8
19
*
L04AX03
ATC
methotrexate; systemic
7.8
18.1
26
36
B01AF01
ATC
rivaroxaban; oral
4.9
17.7
42
96
L17
ICPC
Foot/toe symptom/complaint
2.9
17.4
119
550
WX111
NOMESCO Finland
Local infiltration anesthesia
+∞
16.8
16
*
NFK30
NOMESCO Finland
Angulation, rotation or displacement osteotomy of femur
+∞
16.8
16
*
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
29.5
16.7
22
8
M20.2
ICD-10 Finland
Hallux rigidus
95.5
16.7
18
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.1
16.7
52
147
M01AH05
ATC
etoricoxib; oral
2.8
16.6
190
1139
M17.3
ICD-10 Finland
Other post-traumatic gonarthrosis
50.5
16.2
19
*
NFU20
NOMESCO Finland
Removal of internal fixation device from femur
35.5
15.9
20
6
M16.1
ICD-10 Finland
Other primary coxarthrosis
14.9
15.8
26
19
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
5.0
15.4
35
77
N03AX16
ATC
[U] pregabalin
3.2
15.3
76
291
L28
ICPC
Limited function/disability (L)
3.3
15.3
68
244
S18
ICPC
Laceration/cut
2.6
15.0
155
869
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
4.8
15.0
36
83
9271
FHL
Hallux surgery
+∞
14.7
14
*
NHG70
NOMESCO Finland
Arthroplasty of first tarsometatarsal joint
+∞
14.7
14
*
NHL68
NOMESCO Finland
Tenodesis, shortening or lengthening of tendon of foot
+∞
14.7
14
*
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
5.6
14.7
29
56
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
31.8
14.0
18
6
P01BA02
ATC
hydroxychloroquine; oral
12.9
13.9
24
20
NFK20
NOMESCO Finland
Epiphysiodesis of femur
78.8
13.7
15
*
E66.00
ICD-10 Finland
Metabolic syndrome
5.4
13.7
28
56
NHG82
NOMESCO Finland
Fusion of other tarsal joint
+∞
13.6
13
*
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
+∞
13.6
13
*
7364A
ICD-9 Finland
Other acquired deformities of limbs, Genu valgum or varum (acquired)[GENU VALGUM ACQUISITUM]
+∞
13.6
13
*
73800
ICD-8 Finland
Other deformities, Coxa valga
+∞
13.6
13
*
M19.1
ICD-10 Finland
Post-traumatic arthrosis of other joints
146.3
13.6
14
*
B01AB05
ATC
enoxaparin; parenteral
2.8
13.5
90
403
WX702
NOMESCO Finland
Supraglottic ventilation device
4.8
13.4
32
73
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
4.3
13.0
36
93
L90
ICPC
Osteoarthrosis of knee
13.1
12.8
22
18
NHG24
NOMESCO Finland
Fusion of subtalar joint and between bones of ankle
+∞
12.6
12
*
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
+∞
12.6
12
*
NG1DA
NOMESCO Finland
X-ray of knees
135.4
12.5
13
*
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
12.4
12.5
22
19
NF1AA
NOMESCO Finland
Hip X-ray examination
5.3
12.4
26
53
N06AX21
ATC
duloxetine; oral
3.4
12.4
49
162
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
6.0
12.1
22
39
X59
ICD-10 Finland
Exposure to unspecified factor
2.9
12.0
69
284
NH3EA
NOMESCO Finland
Feet X-ray examination with load
48.7
12.0
14
*
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.6
12.0
91
432
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
17.3
11.8
18
11
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.5
11.7
106
545
N02BF02
ATC
pregabalin; oral
5.0
11.7
26
56
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
5.2
11.7
25
52
M01AH01
ATC
celecoxib; oral
3.1
11.6
54
197
R5110, ,
SPAT
3.9
11.6
36
101
7350A
ICD-9 Finland
Acquired deformities of toe, Hallux valgus (acquired)
+∞
11.5
11
*
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
124.6
11.5
12
*
NHK99
NOMESCO Finland
Other operation on bone of ankle or foot
36.6
11.4
14
*
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.0
11.3
55
206
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.5
11.2
41
129
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
6.0
11.2
20
35
TQW40
NOMESCO Finland
Remowal of suture of skin
4.4
11.1
29
71
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
4.6
11.0
27
63
NG2AA
NOMESCO Finland
Patella X-ray examination
45.1
11.0
13
*
M18.1
ICD-10 Finland
Other primary arthrosis of first carpometacarpal joint
45.1
11.0
13
*
R4110, ,
SPAT
3.1
10.8
51
187
Z96.6
ICD-10 Finland
Presence of orthopaedic joint implants
29.2
10.8
14
5
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
113.8
10.5
11
*
NHL14
NOMESCO Finland
Shortening or lengthening of achilles tendon
113.8
10.5
11
*
M19.2
ICD-10 Finland
Other secondary arthrosis
+∞
10.5
10
*
7151F
ICD-9 Finland
Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, primary[OSTEOARTHROSIS PRIMARIA, POLVI]
+∞
10.5
10
*
M22.0
ICD-10 Finland
Recurrent dislocation of patella
+∞
10.5
10
*
M21.1
ICD-10 Finland
Varus deformity, not elsewhere classified
+∞
10.5
10
*
M01AB05
ATC
diclofenac; systemic, rectal
2.3
10.4
187
1267
H02AB06
ATC
prednisolone; systemic
2.2
10.3
137
823
M15
ICD-10 Finland
Polyarthrosis
5.6
10.3
20
38
R03BA01
ATC
beclometasone; inhalant
2.9
10.2
52
199
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.3
10.2
27
67
N02BF01
ATC
gabapentin; oral
3.5
10.1
36
111
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
41.5
10.0
12
*
M67.0
ICD-10 Finland
Short Achilles tendon (acquired)
41.5
10.0
12
*
J01FF01
ATC
clindamycin; systemic
2.4
10.0
86
428
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
4.0
10.0
30
82
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.6
9.9
34
102
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
10.1
9.9
19
20
N06AA09
ATC
amitriptyline; systemic
3.7
9.9
33
97
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
27.1
9.9
13
5
L29
ICPC
Musculoskeletal sympt/complt other
3.4
9.8
38
124
M70.6
ICD-10 Finland
Trochanteric bursitis
3.0
9.5
46
171
NFB40
NOMESCO Finland
Primary total prosthetic replacement of hip joint using hybrid technique
31.1
9.5
12
*
N02BE01
ATC
paracetamol; systemic, rectal
3.2
9.5
269
2184
M02AA07
ATC
piroxicam; topical
2.2
9.4
102
559
M17.5
ICD-10 Finland
Other secondary gonarthrosis
+∞
9.4
9
*
7363A
ICD-9 Finland
Other acquired deformities of limbs, Acquired deformities of hip[COXA VALGA ACQUISITA]
+∞
9.4
9
*
NHG22
NOMESCO Finland
Fusion of subtalar joint
+∞
9.4
9
*
NGK30
NOMESCO Finland
Angulation, rotation or displacement osteotomy of knee or lower leg
+∞
9.4
9
*
A01
ICPC
Pain general/multiple sites
3.3
9.4
38
127
A02BC05
ATC
esomeprazole; systemic
2.2
9.2
118
691
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.1
9.1
134
827
L88
ICPC
Rheumatoid/seropositive arthritis
37.9
9.1
11
*
X58
ICD-10 Finland
Exposure to other specified factors
2.7
9.0
54
225
R4110
NOMESCO Finland
Physiotherapy
2.3
9.0
84
432
E66.01
ICD-10 Finland
Obesity due to excess calories
3.2
8.9
37
126
M77.4
ICD-10 Finland
Metatarsalgia
4.0
8.8
26
70
L13
ICPC
Hip symptom/complaint
2.6
8.8
57
247
ZXE10
NOMESCO Finland
More than one and less than three hours
2.2
8.7
105
599
M01AX17
ATC
nimesulide; oral
2.5
8.6
64
297
M54.5
ICD-10 Finland
Low back pain
2.1
8.5
106
611
1221
FHL
Arthroscopy and meniscus surgery
92.5
8.5
9
*
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.5
8.5
63
292
Q74.1
ICD-10 Finland
Congenital malformation of knee
+∞
8.4
8
*
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
+∞
8.4
8
*
9273
FHL
Other surgery for toe deformity or pain condition, e.g., Morton, hammer toe
+∞
8.4
8
*
J45.9
ICD-10 Finland
Asthma, unspecified
2.4
8.2
65
309
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
5.0
8.2
18
38
H02AB04
ATC
methylprednisolone; systemic
2.8
8.2
45
179
J01DA01
ATC
[U] cefalexin
2.0
8.2
182
1290
M35.7
ICD-10 Finland
Hypermobility syndrome
17.8
8.1
12
7
NHL99
NOMESCO Finland
Other operation on muscle or tendon of ankle or foot
34.4
8.1
10
*
SAA02
NOMESCO Finland
Basic examination of mouth
2.2
8.0
219
1667
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.3
8.0
31
101
SAA01
NOMESCO Finland
Simple examination of mouth
2.2
7.9
228
1766
M23.3
ICD-10 Finland
Other meniscus derangements
46.2
7.8
9
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.6
7.7
50
216
J46
ICD-10 Finland
Status asthmaticus
8.4
7.7
16
20
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
3.6
7.6
26
78
NE1AA
NOMESCO Finland
Pelvis X-ray examination
4.1
7.6
21
54
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.0
7.5
35
127
M72.2
ICD-10 Finland
Plantar fascial fibromatosis
3.1
7.5
33
116
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.7
7.5
42
169
M21.7
ICD-10 Finland
Unequal limb length (acquired)
82.0
7.4
8
*
NE1AA, ,
SPAT
13.8
7.4
12
9
A02BC02
ATC
pantoprazole; systemic
2.0
7.4
189
1384
L08
ICPC
Shoulder symptom/complaint
2.3
7.4
69
351
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
8.7
7.4
15
18
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.3
7.4
64
316
B01AB04
ATC
dalteparin; parenteral
4.5
7.3
18
42
7360A
ICD-9 Finland
Other acquired deformities of limbs, Acquired deformities of forearm, excluding fingers[CUBITUS VALGUS ACQUISITUS]
+∞
7.3
7
*
NHK68
NOMESCO Finland
Shortening or lengthening osteotomy of ankle or foot
+∞
7.3
7
*
NH1EA
NOMESCO Finland
Ankle X-ray examination with load or wrench
+∞
7.3
7
*
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
+∞
7.3
7
*
TNX92
NOMESCO Finland
Supporting bandage or orthosis of lower limb
16.2
7.3
11
7
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.0
7.3
33
118
M19.8
ICD-10 Finland
Other specified arthrosis
6.9
7.2
17
26
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.0
7.2
100
594
A07EC01
ATC
sulfasalazine; oral, rectal
6.3
7.2
18
30
G56.0
ICD-10 Finland
Carpal tunnel syndrome
2.7
7.1
42
173
SPAT1229
SPAT
Assessment of need for aid
3.6
7.1
24
71
I83.9
ICD-10 Finland
Varicose veins of lower extremities without ulcer or inflammation
2.8
7.0
36
138
L12
ICPC
Hand/finger symptom/complaint
2.3
7.0
59
288
M54.4
ICD-10 Finland
Lumbago with sciatica
2.4
7.0
53
247
R01AD12
ATC
fluticasone furoate; nasal
2.0
7.0
100
600
Z3226
NOMESCO Finland
Physiotherapist
2.3
6.9
56
268
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
6.9
82
460
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.2
6.8
68
355
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.1
6.8
80
445
K02.1
ICD-10 Finland
Caries of dentine
1.9
6.8
186
1377
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
2.6
6.8
42
177
J01AA02
ATC
doxycycline; systemic
2.0
6.8
216
1682
NH1CG
NOMESCO Finland
Ankle and foot extensive MRI examination with high intensity magnet
41.0
6.8
8
*
Q66.0
ICD-10 Finland
Talipes equinovarus
41.0
6.8
8
*
NG1EA
NOMESCO Finland
Knee X-ray examination with wrench
41.0
6.8
8
*
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.9
6.8
164
1168
TNX32
NOMESCO Finland
Custom moulded splint, unspecified region
3.9
6.8
20
54
M10.9
ICD-10 Finland
Gout, unspecified
6.1
6.7
17
29
TPH04
NOMESCO Finland
Cathetrisation of vein
2.2
6.7
66
344
M01AC06
ATC
meloxicam; systemic, rectal
2.0
6.6
93
552
S83.2
ICD-10 Finland
Tear of meniscus, current
4.1
6.5
18
46
A02BC01
ATC
omeprazole; systemic
2.1
6.5
78
437
9481
FHL
Detachment or severance of a muscle or tendon
71.3
6.4
7
*
L01BA01
ATC
methotrexate; systemic
71.3
6.4
7
*
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.6
6.4
38
157
S83.6
ICD-10 Finland
Sprain and strain of other and unspecified parts of knee
3.5
6.4
22
66
M47.82
ICD-10 Finland
Other spondylosis, cervical region
6.2
6.4
16
27
NH1BG
NOMESCO Finland
Ankle and foot MRI examination with high intensity magnet
9.6
6.3
12
13
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
6.3
131
883
NDG71
NOMESCO Finland
Arthrodes of first MP joint
+∞
6.3
6
*
NDG60
NOMESCO Finland
Arthroplasty of first CMC joint
+∞
6.3
6
*
7177A
ICD-9 Finland
Internal derangement of knee, Chondromalacia of patella
+∞
6.3
6
*
SFA10
NOMESCO Finland
One-surface restoration
1.8
6.2
170
1246
Z3229
NOMESCO Finland
Other healthcare associate professional
3.0
6.2
28
100
SPAT1295
SPAT
Other function in accordance with physical therapy nomenclature
3.9
6.2
18
48
SGA01
NOMESCO Finland
Emergency treatment
2.3
6.2
51
246
NG1BA
NOMESCO Finland
Knee extensive X-ray examination
8.9
6.1
12
14
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
4.0
6.1
17
44
SPAT1153
SPAT
Removal of sutures
2.0
6.1
79
455
WZA90
NOMESCO Finland
Other medical or dental certificate
2.0
6.1
76
432
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.7
6.0
34
137

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
179
1019
2.87
17.69
2.8
2.7
—
—
estimate
—
0
0
78
307
3.08
14.96
1.3
1.2
18.35
1.46
u/ml
0.83
24
126
82
363
2.73
12.46
1.3
1.2
16.76
17.25
iu/ml
0.03
24
100
158
989
2.26
10.87
12.6
11.6
1.15
1.20
inr
0.57
130
828
65
279
2.70
10.34
1.9
2.0
—
—
—
0
0
155
1005
2.12
9.29
2.4
2.0
92.47
97.16
pmol/l
0.67
84
516
112
655
2.13
8.67
1.8
1.6
21.83
20.97
nmol/l
0.26
98
552
171
1183
2.03
8.25
10.6
8.0
1.22
1.22
mmol/l
0.43
148
1026
165
1135
2.00
8.01
8.3
5.8
0.64
0.69
%
0.69
152
1066
164
1135
1.98
7.72
8.4
5.8
2.75
2.91
%
0.39
151
1071
164
1135
1.98
7.72
8.3
5.9
8.53
8.68
%
0.29
151
1071
123
773
2.00
7.63
9.0
5.8
—
—
—
0
0
153
1053
1.92
7.14
10.3
7.4
1.22
1.22
mmol/l
0.43
139
978
163
1147
1.92
7.10
8.0
5.6
55.25
56.01
%
0.40
153
1102
178
1290
1.93
7.08
8.6
6.0
0.19
0.19
e9/l
0.09
154
1107
113
709
1.95
6.90
2.5
2.3
—
—
—
0
0
171
1231
1.90
6.86
8.1
5.6
0.55
0.56
e9/l
0.09
151
1041
227
1798
2.07
6.84
8.7
8.0
81.78
78.03
u/l
0.53
222
1686
158
1112
1.89
6.76
3.1
2.6
76.33
77.07
nmol/l
0.12
143
1001
171
1235
1.89
6.75
8.1
5.6
0.04
0.04
e9/l
1.01
151
1046
186
1384
1.90
6.65
6.7
5.4
6.10
6.53
mmol/l
5.20
171
1284
81
459
2.05
6.56
3.4
2.9
349.01
336.81
umol/l
0.42
75
409
46
208
2.43
6.45
3.3
2.2
0.00
0.07
estimate
0.49
13
45
143
986
1.86
6.43
6.1
5.6
35.87
36.15
g/l
0.27
131
939
9
5
18.49
6.30
1.7
1.2
—
—
—
0
0
44
199
2.42
6.16
5.0
4.8
0.00
0.12
%
—
10
57
171
1262
1.82
6.04
8.1
5.7
2.00
2.06
e9/l
0.20
151
1098
161
1170
1.81
5.95
8.6
5.8
29.94
29.25
%
0.37
153
1119
19
55
3.62
5.83
1.1
1.1
—
—
—
0
0
42
195
2.34
5.54
4.7
4.4
0.00
0.13
%
—
9
64
43
206
2.27
5.28
4.7
4.4
0.20
0.84
%
—
10
75
182
1407
1.74
5.13
10.3
9.7
3.89
3.96
e9/l
0.19
162
1202
165
1243
1.72
5.09
4.2
3.0
93.94
96.69
ug/l
0.10
160
1159
9
9
10.26
5.06
1.6
1.0
—
—
—
0
0
164
1235
1.72
5.06
5.8
7.4
10.13
10.98
umol/l
0.77
157
1177
51
267
2.10
5.03
2.4
3.4
4.32
4.99
e9/l
0.33
44
244
40
190
2.27
5.01
4.5
4.5
0.10
0.53
%
—
10
66
83
517
1.84
4.94
2.9
1.7
1.43
1.16
mg/l
0.37
62
392
121
843
1.73
4.91
3.3
3.5
18.53
87.88
ng/l
0.93
84
556
62
360
1.91
4.56
3.7
2.4
14.37
13.73
umol/l
0.30
56
333
48
260
2.01
4.31
1.9
1.6
—
—
—
0
0
114
804
1.67
4.30
3.5
3.2
7.65
7.62
mmol/l
0.02
100
686
7
6
11.90
4.29
1.1
1.2
159.00
128.83
nmol/l
—
7
6
24
98
2.57
4.17
3.2
2.3
22.73
0.03
estimate
0.47
11
29
34
164
2.21
4.11
1.4
1.2
141.84
460.67
u/ml
1.10
29
151
278
2515
2.38
4.06
23.1
15.9
3.92
3.94
mmol/l
0.77
272
2445
35
177
2.11
3.77
2.8
2.1
6.17
6.16
ph
0.03
20
118
26
116
2.36
3.76
10.2
5.5
—
—
—
0
0
46
259
1.92
3.69
1.8
1.3
284.44
434.84
titre
—
9
62
271
2446
2.08
3.67
19.6
13.2
15.79
24.82
mg/l
7.66
234
1894
254
2248
1.83
3.61
6.6
5.6
37.42
38.38
mmol/mol
1.33
238
2089
263
2355
1.92
3.57
6.5
5.2
1.75
1.93
mu/l
2.14
246
2172
95
666
1.62
3.56
1.5
1.4
1.34
2.57
u/ml
0.56
19
173
114
836
1.59
3.54
2.4
4.0
2.35
2.36
mmol/l
0.36
94
757
31
154
2.13
3.50
10.4
5.2
7.40
7.42
ph
0.81
26
126
83
565
1.65
3.49
1.7
1.4
2.27
2.18
g/l
0.19
44
351
103
747
1.58
3.32
5.8
3.0
15.62
50.81
e6/l
2.16
82
554
13
43
3.11
3.29
23.8
6.2
75.93
65.27
%
1.63
13
43
18
72
2.60
3.27
3.1
4.0
23.51
25.22
mmol/l
1.00
18
72
261
2348
1.84
3.25
5.6
4.6
5.76
5.80
mmol/l
0.21
245
2144
285
2645
2.46
3.23
13.9
10.2
25.59
24.63
u/l
0.34
278
2560
29
145
2.11
3.23
1.2
1.1
—
—
—
0
0
116
870
1.54
3.20
7.5
3.5
92.20
92.78
e6/l
0.00
89
593
103
753
1.56
3.18
2.3
2.5
53.78
64.98
u/l
1.01
97
690
100
727
1.56
3.17
7.4
6.3
—
—
—
0
0
231
2018
1.62
3.13
5.3
4.2
14.98
14.75
pmol/l
0.79
210
1850
88
624
1.58
3.09
2.6
2.2
2.78
2.81
mg/l
0.06
79
522
96
701
1.54
2.95
3.4
2.7
—
0.00
—
0
12
160
1302
1.49
2.92
5.9
3.5
0.00
0.00
estimate
0.50
43
250
55
353
1.68
2.86
1.8
1.6
1135.94
1213.17
nmol/l
0.32
48
262
104
779
1.51
2.82
4.4
2.8
—
—
—
0
0
96
709
1.52
2.78
4.0
4.0
7.20
9.63
mg/mmol
0.30
58
442
142
1138
1.47
2.74
16.3
9.5
0.00
0.00
e9/l
1.48
124
896
280
2605
2.07
2.73
17.0
11.7
—
—
—
0
0
65
441
1.60
2.73
6.8
2.7
540.89
533.89
mosm/kgh2o
0.08
60
380
53
342
1.67
2.70
2.6
2.8
141.80
102.00
ug/g
0.53
41
267
94
698
1.50
2.64
3.3
3.3
69.00
55.52
mg/l
0.18
55
447
23
115
2.08
2.58
4.0
3.0
1.01
1.02
ratio
0.92
18
109
37
219
1.79
2.56
13.6
4.3
5.21
4.62
kpa
0.49
37
212
94
705
1.48
2.49
4.6
4.0
7.39
7.40
ph
0.28
66
496
41
253
1.72
2.47
12.9
4.9
7.37
7.38
ph
0.05
30
158
10
32
3.20
2.46
1.7
1.3
4.60
3.47
u/ml
—
5
19
54
360
1.61
2.43
4.4
2.8
3.60
2.99
e6/l
0.14
31
169
17
77
2.28
2.42
5.5
4.2
128.71
217.76
mg/l
—
7
38
97
736
1.47
2.42
5.0
2.8
7.35
0.01
estimate
0.49
34
203
100
765
1.46
2.39
1.4
1.5
—
—
—
0
0
155
1286
1.42
2.38
6.0
3.4
0.00
0.00
estimate
0.50
44
261
7
17
4.19
2.37
1.0
1.4
1.58
1.85
mmol/l
—
7
17
156
1297
1.42
2.36
6.2
3.5
0.00
0.00
estimate
-0.00
42
259
34
202
1.77
2.33
4.8
3.8
7.39
7.36
ph
0.87
20
142
9
28
3.28
2.32
1.2
1.7
14.45
16.53
ug/l
—
9
28
46
298
1.64
2.32
11.1
8.6
105.74
104.40
mmol/l
0.99
46
298
120
956
1.42
2.29
2.1
2.1
—
—
—
0
0
6
13
4.69
2.28
2.5
1.8
94.17
74.18
ng/l
—
6
13
42
268
1.66
2.24
1.3
1.3
—
—
—
0
0
40
252
1.68
2.24
13.1
4.8
5.98
5.77
kpa
0.73
40
245
86
646
1.46
2.24
5.2
3.0
0.20
0.44
e6/l
1.46
65
460
46
301
1.62
2.23
1.2
1.3
—
—
—
0
0
26
144
1.88
2.23
1.3
1.3
—
—
—
0
0
10
37
2.76
2.09
1.2
1.2
—
—
—
0
0
6
15
4.06
2.05
1.0
1.1
—
—
—
0
0
65
470
1.49
2.04
1.6
1.7
122807410.58
29695878.73
pmol/l
0.33
57
394
8
26
3.13
2.03
2.0
1.8
1.10
0.85
%
—
8
15
8
26
3.13
2.03
5.5
1.5
10.75
10.77
mmol/l
—
8
26
37
235
1.65
2.02
1.3
1.2
—
—
—
0
0
123
1003
1.38
1.99
5.5
3.3
0.00
0.03
estimate
1.15
35
215
7
21
3.39
1.97
8.4
2.1
41.83
38.86
%
—
7
21
126
1034
1.38
1.96
1.8
1.9
1.33
1.33
mmol/l
0.00
113
866
20
107
1.93
1.91
4.0
1.9
—
—
—
0
0
13
59
2.26
1.87
2.1
2.6
4.00
3.07
index
—
8
29
34
216
1.65
1.86
8.3
10.0
—
—
—
0
0
75
569
1.42
1.83
5.6
4.8
—
—
—
0
0
15
76
2.02
1.67
1.1
1.4
285.77
287.62
ug/g
—
7
46
8
31
2.62
1.67
1.4
1.3
—
—
—
0
0
8
32
2.54
1.61
2.1
1.4
9.88
29.87
ng/l
—
8
32
19
107
1.83
1.58
1.9
1.4
—
—
—
0
0
76
594
1.37
1.55
4.1
4.2
—
—
—
0
0
258
2419
1.47
1.52
5.3
4.6
4.55
4.69
mmol/l
1.53
243
2265
34
230
1.54
1.47
1.3
1.4
—
—
—
0
0
36
247
1.52
1.46
5.3
11.1
7.41
7.43
ph
0.52
18
145
6
22
2.76
1.44
3.7
2.4
—
—
—
0
0
6
22
2.76
1.44
1.3
2.2
92.12
90.30
%
—
6
22
10
46
2.21
1.41
1.0
1.4
—
—
—
0
0
256
2406
1.43
1.40
5.2
4.5
1.45
1.50
mmol/l
1.35
239
2236
16
268
0.57
1.35
1.4
1.3
—
—
—
0
0
10
47
2.17
1.35
6.4
1.4
68.80
56.45
mmol/l
—
10
38
42
303
1.45
1.35
1.2
1.2
—
—
—
0
0
12
61
2.01
1.34
2.2
1.3
—
3.03
—
0
9
25
161
1.60
1.33
1.8
1.2
—
—
—
0
0
35
244
1.49
1.33
4.7
11.1
-0.11
1.30
mmol/l
1.36
25
200
242
2268
1.34
1.22
4.4
3.9
1.31
1.23
mmol/l
0.90
224
2096
88
729
1.29
1.20
7.0
3.4
0.00
0.00
estimate
0.50
40
246
11
57
1.97
1.18
1.6
1.3
58.00
126.67
titre
—
5
6
24
351
0.66
1.17
1.5
1.5
—
—
—
0
0
74
603
1.30
1.14
5.1
3.5
1.02
1.02
kg/l
0.06
48
396
35
253
1.43
1.13
3.9
3.3
1.59
1.73
%
0.51
29
228
57
449
1.33
1.11
5.9
5.0
2.11
2.16
ug/l
0.04
50
405
258
2451
1.37
1.11
5.9
5.2
2.69
2.74
mmol/l
0.47
240
2285
36
263
1.42
1.10
1.6
1.7
—
—
—
0
0
5
21
2.40
1.09
1.4
1.5
—
—
—
0
0
37
273
1.41
1.07
3.4
3.6
4.07
6.65
umol/l
1.28
32
232
24
163
1.51
1.05
1.2
3.7
66.93
67.08
g/l
0.04
24
151
5
22
2.29
1.04
1.2
1.1
—
—
—
0
0
5
22
2.29
1.04
1.4
1.1
—
—
—
0
0
7
34
2.08
1.03
7.0
2.0
16.54
16.15
%
—
7
34
38
284
1.39
1.03
1.2
1.6
—
—
—
0
0
20
132
1.55
1.00
1.3
3.1
—
—
—
0
0
54
432
1.30
0.95
4.1
3.9
168.40
504.23
ng/l
1.11
36
318
6
27
2.25
0.94
48.3
8.4
13.23
11.60
%
—
6
27
6
28
2.17
0.92
1.8
1.9
33.50
31.18
pg
—
6
28
6
29
2.09
0.90
2.8
1.8
1.75
1.56
mmol/l
—
6
29
8
42
1.93
0.89
1.1
1.1
—
—
—
0
0
118
1052
1.20
0.80
4.5
3.1
6.29
6.29
ph
0.02
73
628
8
48
1.68
0.79
1.4
1.1
—
—
—
0
0
0
26
0.00
0.79
0.0
1.1
—
—
—
0
0
6
34
1.78
0.76
6.3
2.9
3.95
4.09
e9/l
—
6
34
7
38
1.86
0.74
16.7
3.2
—
—
—
0
0
9
57
1.60
0.72
4.4
3.8
—
—
—
0
0
5
26
1.94
0.71
1.0
1.5
—
—
nmol/l
—
0
0
5
28
1.80
0.66
2.8
3.6
—
—
—
0
0
8
51
1.58
0.61
2.8
1.4
—
—
—
0
0
0
21
0.00
0.60
0.0
1.0
—
—
—
0
0
20
150
1.36
0.57
1.5
1.9
—
—
—
0
0
15
107
1.42
0.56
2.3
2.1
—
—
—
0
0
13
90
1.46
0.56
2.4
1.2
—
—
—
0
0
10
65
1.56
0.56
1.7
2.8
—
—
—
0
0
20
152
1.34
0.53
1.5
1.9
—
—
—
0
0
20
152
1.34
0.53
1.5
1.9
—
—
—
0
0
17
220
0.76
0.46
1.5
1.4
—
—
—
0
0
26
211
1.25
0.45
8.4
3.2
—
—
—
0
0
7
50
1.41
0.45
4.1
4.1
14.00
239.27
u/ml
—
7
45
208
2159
0.88
0.43
24.2
17.5
332.64
332.40
g/l
0.13
208
2150
19
150
1.28
0.41
1.5
1.9
—
—
—
0
0
0
17
0.00
0.41
0.0
1.4
—
—
—
0
0
5
35
1.44
0.39
1.0
1.1
—
—
—
0
0
33
282
1.19
0.37
3.1
2.8
0.73
0.78
ug/l
0.10
18
168
6
41
1.47
0.36
20.7
2.6
9.95
7.41
pmol/l
—
6
41
5
78
0.64
0.36
1.0
1.2
—
—
—
0
0
10
134
0.74
0.35
2.2
1.7
—
—
—
0
0
10
73
1.38
0.35
1.3
2.3
—
—
—
0
0
17
138
1.25
0.31
1.5
1.9
—
—
—
0
0
30
343
0.86
0.29
1.8
1.8
—
—
—
0
0
8
65
1.24
0.27
2.1
1.3
1.19
1.23
g/l
—
8
60
9
75
1.21
0.25
1.8
1.3
—
—
—
0
0
52
478
1.11
0.23
2.3
3.2
2.45
2.46
mmol/l
0.08
46
426
10
79
1.27
0.22
2.6
1.2
—
—
—
0
0
14
116
1.22
0.22
1.3
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
0.00
—
0
12
0
12
0.00
0.21
0.0
2.1
—
140.75
—
0
12
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
5
43
1.17
0.21
4.0
3.8
0.94
0.83
nmol/l
—
5
37
28
250
1.13
0.20
3.6
4.8
2.58
35.36
ug/l
0.66
22
212
0
14
0.00
0.20
0.0
2.3
—
—
—
0
0
6
49
1.23
0.20
1.2
1.1
—
—
—
0
0
6
49
1.23
0.20
1.2
1.1
—
—
—
0
0
6
50
1.20
0.20
6.2
2.0
131.83
129.18
g/l
—
6
38
6
53
1.13
0.19
1.2
1.9
—
—
—
0
0
7
59
1.19
0.18
1.4
1.0
—
—
—
0
0
45
483
0.92
0.17
1.9
1.7
—
—
—
0
0
12
101
1.20
0.17
1.2
1.2
0.80
0.86
g/l
0.48
12
101
15
130
1.16
0.16
2.3
7.6
—
—
—
0
0
16
140
1.15
0.15
7.1
12.0
0.52
0.68
%
1.26
16
140
16
141
1.14
0.14
7.1
12.0
93.94
93.44
%
0.10
16
141
14
123
1.14
0.12
1.0
1.1
—
—
—
0
0
12
104
1.16
0.12
1.0
1.2
—
—
—
0
0
21
193
1.09
0.10
1.2
1.2
42.83
136.21
u/ml
—
6
70
6
57
1.05
0.08
8.8
2.7
59.33
55.85
%
—
6
57
6
58
1.04
0.08
1.8
1.7
188.33
208.04
pmol/l
—
6
52
22
236
0.93
0.08
1.7
1.7
3.49
3.45
mmol/l
0.06
16
176
5
65
0.77
0.08
2.2
1.5
0.16
0.33
nmol/l
—
5
54
11
98
1.13
0.08
1.2
1.1
1.49
1.56
g/l
0.36
11
98
6
73
0.82
0.07
11.0
9.7
—
—
—
0
0
29
306
0.94
0.07
1.9
1.6
—
—
—
0
0
19
202
0.94
0.05
1.3
1.6
—
—
—
0
0
58
569
1.02
0.03
1.9
2.0
—
—
—
0
0
15
142
1.06
0.02
7.5
11.9
1.15
1.37
%
0.52
15
142
100
1008
0.99
0.01
3.1
3.0
—
—
—
0
0
17
172
0.99
0.00
3.6
2.9
—
—
—
0
0
5
50
1.00
0.00
1.2
1.4
—
—
—
0
0
9
99
0.91
-0.00
2.1
2.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
85
0.94
-0.00
1.1
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
117.37
—
0
9
7
78
0.90
-0.00
1.3
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
10.2
—
24.60
—
0
5
9
96
0.94
-0.00
2.6
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.6
—
0.60
—
0
7
0
7
0.00
-0.00
0.0
1.0
—
15.89
—
0
7
0
6
0.00
-0.00
0.0
2.8
—
5.44
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
69.94
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
7.0
—
4.99
—
0
8

Mortality – FinRegistry

Association

Association between endpoint M13_VALGUS and mortality.

Females

Parameter HR [95% CI] p-value
M13_VALGUS 0.979 [0.79, 1.21] 0.846
Birth year 0.994 [0.99, 1.0] 0.186

During the follow-up period (1.1.1998 — 31.12.2019), 113 out of 1234 females with M13_VALGUS died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have M13_VALGUS.

N-year risk Females Males
1 0.108% No data
5 0.609% No data
10 1.436% No data
15 2.867% No data
20 4.812% No data

Relationships between endpoints

Index endpoint: M13_VALGUS – Valgus deformity, not elsewhere classified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data