spondyloarthropathy: A group of inflammatory rheumatic diseases associated with arthritis and enthesitis, and often involving the axial skeleton. The most common form of spondyloarthritis is ankylosing spondylitis. Other forms include axial spondyloarthritis, peripheral spondyloarthritis, reactive arthritis, psoriatic arthritis/spondylitis and enteropathic arthritis/spondylitis.
Spondylopathies in diseases classified elsewhere
DOID EFO Endpoint Browser PheWeb
M13_SPONDYLOPATHINOTH
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
590 |
4. Check minimum number of eventsNone |
590 |
5. Include endpointsNone |
590 |
6. Filter based on genotype QC (FinnGen only) |
459 |
Control definitions (FinnGen only)
- Control exclude
- M13_DORSOPATHY
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Spondylopathies in diseases classified elsewhere
based on the number of shared cases.
Similar with more cases:
- Spondylopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2934 | 1388 | 1517 |
| Only index persons | 2404 | 1175 | 1229 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.04 |
| Only index persons | 0.05 | 0.04 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 67.32 | 67.49 | 67.19 |
| Only index persons | 67.27 | 67.47 | 67.08 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 459 | 205 | 254 |
| Unadjusted period prevalence (%) | 0.10 | 0.07 | 0.12 |
| Median age at first event (years) | 69.46 | 66.39 | 71.94 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 480
- Matched controls
- 4800
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
63.4
310.2
180
45
M49.5*C79.5
ICD-10 Finland
Metastatic fracture of vertebra
+∞
300.7
256
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
37.7
295.8
205
93
N02AA05
ATC
oxycodone; systemic
13.5
188.7
315
596
C90.0
ICD-10 Finland
Multiple myeloma
58.2
164.4
94
20
H02AB02
ATC
dexamethasone; systemic
10.9
152.5
232
378
M48.0
ICD-10 Finland
Spinal stenosis
46.0
144.3
87
23
M05BX04
ATC
denosumab; parenteral
14.0
138.6
149
150
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
17.1
130.3
119
91
L04AX04
ATC
lenalidomide; oral
77.7
124.1
67
10
9732/3-C42.1
ICD-O-3
Plasma cell myeloma of bone marrow
51.0
119.6
70
16
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
25.9
101.4
73
33
Z51.5
ICD-10 Finland
Palliative care
8.1
100.1
173
311
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
21.0
98.7
78
44
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
11.8
97.3
111
119
N03AX16
ATC
[U] pregabalin
7.1
91.5
188
401
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
35.1
87.1
56
18
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
23.6
83.5
62
30
M49.5*C90.0
ICD-10 Finland
Vertebral fracture due to multiple myeloma
+∞
81.6
76
*
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
52.0
80.9
47
10
A04AA01
ATC
ondansetron; systemic, rectal
7.7
79.5
134
230
WF004
NOMESCO Finland
Palliative radiotherapy
16.2
79.2
71
51
XX3DW
NOMESCO Finland
Time consuming IT work
6.6
76.8
159
336
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
26.3
76.2
54
23
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
10.2
74.2
92
109
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
9.2
73.3
100
134
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
5.4
72.3
305
1178
A03FA01
ATC
metoclopramide; systemic, rectal
5.2
70.8
228
706
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
20.4
67.4
53
29
153
Kela drug reimbursment
Lenalidomid
95.5
67.2
73
9
YN7AD
NOMESCO Finland
CT examination of spine for dose design of radiotherapy
133.9
65.8
69
6
N03AX12
ATC
[U] gabapentin; oral
6.6
65.5
126
245
JN4AD
NOMESCO Finland
Body CT examination
5.4
62.6
161
408
M54.9
ICD-10 Finland
Dorsalgia, unspecified
8.1
61.2
92
137
M49.5
ICD-10 Finland
Collapsed vertebra in diseases classified elsewhere
+∞
60.7
57
*
M54.5
ICD-10 Finland
Low back pain
4.7
59.4
203
645
WD505
NOMESCO Finland
Simple enzyme inhibitor or similar therapy of methastized malignancy
23.5
58.4
43
20
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.2
56.1
147
375
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
8.1
54.7
81
118
L03AA02
ATC
filgrastim; parenteral
9.5
54.5
69
83
ZX112
NOMESCO Finland
Subcutaneous
12.3
53.8
56
51
WZC00
NOMESCO Finland
Treatment plan or consultation
4.2
53.5
281
1203
329
Kela drug reimbursment
Lenalidomide
123.9
52.0
55
5
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
15.2
51.7
47
34
A06AH03
ATC
naloxegol; oral
17.1
48.3
41
26
N02AX02
ATC
tramadol; systemic, rectal
3.8
45.2
270
1222
JN4BD
NOMESCO Finland
Extensive body CT
4.5
43.2
129
359
ZX120
NOMESCO Finland
Intravenous
5.1
42.4
105
251
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
72.4
40.9
46
7
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
8.7
38.2
51
65
XW000
NOMESCO Finland
Bone marrow biopsy
6.4
37.0
66
116
R50.9
ICD-10 Finland
Fever, unspecified
3.9
35.6
131
420
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.5
35.2
100
265
130
Kela drug reimbursment
Malignant tumour
4.1
34.7
115
342
M49.0*A18.0
ICD-10 Finland
Tuberculosis of spine
+∞
33.7
32
*
M54.4
ICD-10 Finland
Lumbago with sciatica
4.9
33.6
83
196
L03AA13
ATC
pegfilgrastim; parenteral
6.4
33.2
59
103
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.2
31.7
321
1863
NK6AN
NOMESCO Finland
Total body bone isotope imaging
6.7
31.7
53
87
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
55.4
30.8
36
7
393
Kela drug reimbursment
Pomalidomide
114.0
30.0
32
*
WW500
NOMESCO Finland
Blood transfusion
5.9
30.0
58
110
M49.4*G95.0
ICD-10 Finland
Neuropathic spondylopathy in syringomyelia and syringobulbia
+∞
29.5
28
*
WD325
NOMESCO Finland
Demanding therapy of methastized malignancy with biomodifiers
11.0
29.2
32
31
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
85.6
29.1
32
*
1507
Kela drug reimbursment
Pomalidomide
159.6
29.0
30
*
L04AX06
ATC
pomalidomide; oral
159.6
29.0
30
*
A06AD11
ATC
lactulose; oral
3.4
28.6
128
461
N02BF02
ATC
pregabalin; oral
6.2
27.5
50
89
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
5.0
27.3
64
144
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
5.2
27.0
60
129
A79
ICPC
Malignancy NOS
9.7
26.8
32
35
NJ3DA
NOMESCO Finland
Long bones of extremities X-ray examination
33.1
26.3
34
11
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
4.5
26.1
71
180
NAG53
NOMESCO Finland
Posterior or lateral fusion of thoracic spine with fixation, more than 3 vertebraea
+∞
25.2
24
*
A28
ICPC
Limited function/disability NOS
3.0
25.2
152
647
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
10.6
24.9
28
28
YL1AD
NOMESCO Finland
CT examination of pelvis for dose design of radiotherapy
7.7
24.9
36
50
YN7BD
NOMESCO Finland
Extensive CT examination of spine for dose design of radiotherapy
95.2
24.9
27
*
B01AB05
ATC
enoxaparin; parenteral
2.7
24.9
210
1066
116
Kela drug reimbursment
Prostate cancer
4.1
24.3
74
204
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
59.3
24.3
28
5
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
71.3
24.1
27
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.9
24.0
151
656
A02BC02
ATC
pantoprazole; systemic
3.1
24.0
377
2595
G95.0
ICD-10 Finland
Syringomyelia and syringobulbia
252.1
23.9
24
*
N02BF01
ATC
gabapentin; oral
4.5
23.6
63
157
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.2
23.6
115
432
L28
ICPC
Limited function/disability (L)
2.9
23.4
139
584
163
Kela drug reimbursment
Abiraterone and enzalutamide
19.8
23.4
35
19
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
23.5
23.3
33
15
AA1AA
NOMESCO Finland
Head X-ray examination
20.2
22.9
34
18
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
7.5
22.3
33
47
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.1
22.0
113
436
WW300
NOMESCO Finland
Transfer of autologic stem cells
40.8
21.9
27
7
NK6CT
NOMESCO Finland
Bone biopsy with CT guidance
45.6
21.6
26
6
M54.8
ICD-10 Finland
Other dorsalgia
8.7
21.6
28
34
L02BB04
ATC
enzalutamide; oral
22.0
21.5
31
15
L01AA03
ATC
melphalan; systemic
52.6
21.3
25
5
SPAT1229
SPAT
Assessment of need for aid
4.0
21.3
65
179
WZC30
NOMESCO Finland
Teaching
2.9
20.8
121
499
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.5
20.7
189
979
WX2DD
NOMESCO Finland
Low-dose CT of skeleton in whole body
43.9
20.6
25
6
NE1AD
NOMESCO Finland
Pelvis and hip bones CT examination
7.8
20.6
29
39
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.7
20.4
146
671
NAR00
NOMESCO Finland
Complete excision of tumour of bone or cartilage of spine, unspecified
+∞
19.9
19
*
YG1AD
NOMESCO Finland
CT examination of thorax for dose design of radiotherapy
6.8
19.9
32
50
C64.88
ICD-10 Finland
Other malignant neoplasm of kidney, except renal pelvis
6.5
19.6
33
54
S22.0
ICD-10 Finland
Fracture of thoracic vertebra
16.5
19.5
31
20
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.0
19.5
60
166
SPAT1255
SPAT
Intravenous administration of medicine
4.0
19.2
58
158
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.0
19.1
99
382
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
57.5
19.1
22
*
WD205
NOMESCO Finland
Therapy of methastized malignancy with hormones
16.8
19.0
30
19
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
21.9
18.8
27
13
L03
ICPC
Low back symptom/complaint
2.6
18.6
135
621
J01MA12
ATC
levofloxacin; systemic
2.6
18.5
133
609
YX9BD
NOMESCO Finland
Other extensive CT eamination for dose design of radiotherapy
20.4
18.4
27
14
NA2CG
NOMESCO Finland
Thoracal spine extensive MRI examination with high intensity magnet
22.8
18.4
26
12
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.6
18.0
66
206
A04AA02
ATC
granisetron; systemic, transdermal
3.6
18.0
65
201
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.0
17.9
89
335
M54.6
ICD-10 Finland
Pain in thoracic spine
5.0
17.9
40
86
TPH07
NOMESCO Finland
Cathetrisation of artery
3.0
17.9
91
347
M90.7*C90.0
ICD-10 Finland
Pathological fracture in multiple myeloma
+∞
17.8
17
*
M87.1
ICD-10 Finland
Osteonecrosis due to drugs
30.1
17.6
23
8
WD515
NOMESCO Finland
Demanding therapy of malignancy with enzyme inhibitors and similar treatments
43.7
17.4
21
5
L86
ICPC
Back syndrome with radiating pain
5.1
17.4
38
80
AA1AD
NOMESCO Finland
CT of head and brain
2.3
17.3
186
1019
NA1AD
NOMESCO Finland
Cervical spine CT examination
5.0
17.1
38
81
NA2AD
NOMESCO Finland
Thoracic spine CT examination
52.0
17.1
20
*
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
18.8
16.6
25
14
N06AX21
ATC
duloxetine; oral
3.6
16.3
58
177
L02BX03
ATC
abiraterone; oral
17.5
16.2
25
15
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
5.9
16.2
30
54
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
5.9
16.2
30
54
M84.4
ICD-10 Finland
Pathological fracture, not elsewhere classified
49.3
16.1
19
*
M47.9
ICD-10 Finland
Spondylosis, unspecified
49.3
16.1
19
*
M54.2
ICD-10 Finland
Cervicalgia
4.6
16.0
39
90
R11
ICD-10 Finland
Nausea and vomiting
3.4
15.7
61
197
1523, ,
Kela drug reimbursment
23.0
15.7
22
10
3054, ,
Kela drug reimbursment
23.0
15.7
22
10
NE1AA
NOMESCO Finland
Pelvis X-ray examination
3.5
15.6
59
187
X76
ICPC
Malignant neoplasm breast female
6.5
15.6
26
42
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.0
15.6
78
293
ABC56
NOMESCO Finland
Decompression of lumbar spinal canal and nerve roots
165.2
15.6
16
*
C03CA01
ATC
furosemide; systemic
2.2
15.4
210
1257
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.4
15.4
58
184
S32.0
ICD-10 Finland
Fracture of lumbar vertebra
5.5
15.3
30
57
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
4.6
15.2
37
85
M03BC01
ATC
orphenadrine (citrate); systemic
2.7
15.2
95
402
C61
ICD-10 Finland
Malignant neoplasm of prostate
2.7
15.2
91
377
H02AB06
ATC
prednisolone; systemic
2.2
15.1
252
1629
N02AJ06
ATC
codeine and paracetamol; systemic
2.2
15.0
203
1208
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
5.1
15.0
32
66
352
Kela drug reimbursment
Abiraterone and enzalutamide
17.2
14.9
23
14
1501
Kela drug reimbursment
Palbociclib
26.0
14.8
20
8
1XX32, ,
NOMESCO Finland
+∞
14.7
14
*
197
Kela drug reimbursment
Sunitinib
37.3
14.5
18
5
B03XA02
ATC
darbepoetin alfa; parenteral
5.8
14.5
27
49
WD225
NOMESCO Finland
Demanding therapy of methastized malignancy with hormones
11.9
14.5
26
23
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.7
14.4
89
374
NA3DG
NOMESCO Finland
Lumbar spine very extensive MRI examination with high intensity magnet
28.2
14.4
19
7
L02BA03
ATC
fulvestrant; parenteral
23.1
14.3
20
9
Y77
ICPC
Malignant neoplasm prostate
4.3
14.3
38
94
ZX090
NOMESCO Finland
Other technic of radiotherapy
4.6
14.0
34
78
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.1
13.9
207
1269
D48.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage
14.1
13.9
23
17
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
12.6
13.7
24
20
NAG63
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, more than 3 vertebraea
+∞
13.6
13
*
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
5.8
13.5
25
45
394
Kela drug reimbursment
Palbociclib
26.6
13.5
18
7
L02AE02
ATC
leuprorelin; implant, parenteral
3.6
13.4
47
142
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
2.6
13.3
85
362
R52.2
ICD-10 Finland
Other chronic pain
6.0
13.3
24
42
C64
ICD-10 Finland
Malignant neoplasm of kidney, except renal pelvis
12.7
13.2
23
19
L02BB03
ATC
bicalutamide; oral
4.4
13.2
34
82
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.0
13.2
251
1676
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
29.3
13.0
17
6
WX408
NOMESCO Finland
General anesthesy, balanced
2.2
12.8
141
766
M03BX02
ATC
tizanidine; oral
2.0
12.7
260
1773
ZZH31
NOMESCO Finland
Bone allograft, small pieces
33.0
12.6
16
5
A18.0
ICD-10 Finland
Tuberculosis of bones and joints
+∞
12.6
12
*
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
20.7
12.5
18
9
J05AB01
ATC
aciclovir; systemic
2.3
12.5
120
615
SPAT1254
SPAT
Administration of medicine
2.4
12.3
94
435
B01AB10
ATC
tinzaparin; parenteral
2.7
12.3
73
300
M04AA01
ATC
allopurinol; systemic
2.4
12.2
100
478
WW409
NOMESCO Finland
Other aferesis
27.5
12.1
16
6
J01MA02
ATC
ciprofloxacin; systemic
2.0
12.1
209
1337
WPA10
NOMESCO Finland
Proactive palliative care treatment plan
12.1
11.9
21
18
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
4.7
11.8
28
63
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.2
11.8
50
170
N02AA01
ATC
morphine; systemic, rectal
5.7
11.7
22
40
5BA08, ,
NOMESCO Finland
19.5
11.7
17
9
398
Kela drug reimbursment
Ixazomib
+∞
11.5
11
*
115
Kela drug reimbursment
Breast cancer
2.8
11.5
60
230
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
15.5
11.4
18
12
XKC03
NOMESCO Finland
Water cystometry
4.9
11.3
25
53
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
4.4
11.2
28
66
N02BE01
ATC
paracetamol; systemic, rectal
2.9
11.1
434
3685
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.4
11.0
83
381
N07BC02
ATC
methadone; systemic
44.4
11.0
13
*
192
Kela drug reimbursment
Fulvestrant
18.3
10.8
16
9
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
10.8
148
865
A07AA02
ATC
nystatin; oral
3.4
10.8
39
120
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
5.8
10.8
20
36
L02BG06
ATC
exemestane; oral
5.8
10.8
20
36
1502
Kela drug reimbursment
Cabozantinib
22.1
10.7
15
7
3012
Kela drug reimbursment
Cabozantinib
22.1
10.7
15
7
WX704
NOMESCO Finland
Intubation
3.1
10.7
47
163
L02BG04
ATC
letrozole; oral
3.0
10.7
48
169
B74
ICPC
Malignant neoplasm blood other
61.4
10.7
12
*
EB1CI
NOMESCO Finland
Cone beam imaging of teeth and jaws (3-4 quarters)
10.4
10.6
20
20
EBA10
NOMESCO Finland
Operative extraction of tooth
2.8
10.5
54
205
NAJ22
NOMESCO Finland
Posterior reduction of fractrue of thoracic spine
112.4
10.5
11
*
YNB10
NOMESCO Finland
Collection of stem cells for transplant
112.4
10.5
11
*
NAG62
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, 2-3 vertebraea
+∞
10.5
10
*
1505
Kela drug reimbursment
Ixazomib
+∞
10.5
10
*
M47.1
ICD-10 Finland
Other spondylosis with myelopathy
+∞
10.5
10
*
WW402
NOMESCO Finland
Leucoferesis
+∞
10.5
10
*
M43.1
ICD-10 Finland
Spondylolisthesis
16.5
10.4
16
10
ZXE20
NOMESCO Finland
More than three and less than five hours
2.4
10.3
82
385
M05BA02
ATC
clodronic acid; systemic
13.5
10.2
17
13
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
3.2
10.1
42
141
N06AA09
ATC
amitriptyline; systemic
3.0
10.0
46
164
M43.0
ICD-10 Finland
Spondylolysis
41.0
10.0
12
*
GA5AA
NOMESCO Finland
Rib X-ray examination
41.0
10.0
12
*
NF3AA
NOMESCO Finland
Femur X-ray examination
4.9
9.9
22
47
M05BA04
ATC
alendronic acid; oral
2.7
9.9
56
224
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
3.8
9.9
30
82
B01AB04
ATC
dalteparin; parenteral
3.5
9.8
34
102
J05AB11
ATC
valaciclovir; oral
2.3
9.7
82
395
Z01.8
ICD-10 Finland
Other specified special examinations
2.1
9.7
112
612
L01XE04
ATC
[U] sunitinib
56.2
9.7
11
*
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
4.6
9.7
23
52
X59
ICD-10 Finland
Exposure to unspecified factor
2.2
9.6
91
460
WF003
NOMESCO Finland
Adjuvant radiotherapy
3.7
9.5
30
84
ZX080
NOMESCO Finland
Image guided radiotherapy
4.4
9.5
24
57
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
7.2
9.4
22
32
7227C
ICD-9 Finland
Intervertebral disk disorders, Intervertebral disk disorder with myelopathy[SYNDROMA ISCHIADICUM]
+∞
9.4
9
*
NAG52
NOMESCO Finland
Posterior or lateral fusion of thoracic spine with fixation, 2-3 vertebraea
+∞
9.4
9
*
M46.4
ICD-10 Finland
Discitis, unspecified
+∞
9.4
9
*
ABC16
NOMESCO Finland
Microsurgical excision of lumbar intervertebral disc displacement
+∞
9.4
9
*
L01XE26
ATC
[U] cabozantinib
+∞
9.4
9
*
M54.3
ICD-10 Finland
Sciatica
5.0
9.4
20
41
166
Kela drug reimbursment
Dalteparin and tinzaparin (treatment for more than 6 months)
8.9
9.4
19
22
A03FA02
ATC
cisapride; oral, rectal
2.9
9.3
44
159
ZXD05
NOMESCO Finland
Urgent procedure
1.9
9.3
153
945
M01AH05
ATC
etoricoxib; oral
1.8
9.2
262
1917
L02BX02
ATC
degarelix; parenteral
9.3
9.1
18
20
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
37.4
9.1
11
*
JN3AD
NOMESCO Finland
Abdominal CT examination
2.3
9.0
77
372
AA1BD
NOMESCO Finland
Extensive CT of head and brain
4.3
9.0
23
55
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
3.9
9.0
27
73
UKC02
NOMESCO Finland
Cystoscopy
2.1
9.0
102
552
L01XE33
ATC
[U] palbociclib
24.5
8.9
12
5
SAA03
NOMESCO Finland
Extended examination of mouth
1.8
8.9
173
1123
WW200
NOMESCO Finland
Immunization
4.8
8.9
20
43
J01MA14
ATC
moxifloxacin; systemic
2.6
8.8
54
224
M54.1
ICD-10 Finland
Radiculopathy
9.7
8.8
17
18
ZXM20
NOMESCO Finland
Intraoperative use of computerised tomography
50.9
8.7
10
*
M48.5
ICD-10 Finland
Collapsed vertebra, not elsewhere classified
50.9
8.7
10
*
NA2DG
NOMESCO Finland
Thoracal spine very extensive MRI examination with high intensity magnet
50.9
8.7
10
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.0
8.7
105
582
L01CA04
ATC
vinorelbine; systemic
9.2
8.6
17
19
R06AE07
ATC
cetirizine; oral
1.8
8.5
184
1233
R52.1
ICD-10 Finland
Chronic intractable pain
91.6
8.4
9
*
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.2
8.4
82
418
A04
ICPC
Weakness/tiredness general
2.1
8.4
85
440
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
+∞
8.4
8
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.5
8.3
53
224
JN4CD
NOMESCO Finland
Very extensive body CT
3.2
8.3
33
108
N05CF01
ATC
zopiclone; oral
1.8
8.3
162
1050
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
2.8
8.3
43
164
WVA30, ,
SPAT
2.8
8.3
43
164
R52.0
ICD-10 Finland
Acute pain
4.3
8.3
21
50
NB6AA
NOMESCO Finland
Humerus X-ray examination
4.7
8.2
19
42
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.5
8.1
54
233
L02
ICPC
Back symptom/complaint
2.6
8.1
47
190
L84
ICPC
Back syndrome without radiat pain
3.7
8.1
26
74
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.8
8.0
185
1259
GD1AD
NOMESCO Finland
Thorax CT examination
2.7
7.8
43
169
C90.2
ICD-10 Finland
Extramedullary plasmacytoma
45.7
7.7
9
*
G95.8
ICD-10 Finland
Other specified diseases of spinal cord
45.7
7.7
9
*
SPAT1263
SPAT
Sampling
1.7
7.7
196
1365
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.2
7.7
30
97
N03AE01
ATC
clonazepam; systemic
3.3
7.7
29
92
L01EF01
ATC
palbociclib; oral
18.7
7.6
11
6
XKD03
NOMESCO Finland
Urethral pressure profilometry
6.3
7.6
19
31
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.4
7.6
55
247
S22.1
ICD-10 Finland
Multiple fractures of thoracic spine
81.3
7.4
8
*
ABC53
NOMESCO Finland
Decompression of thoracic spinal canal and nerve roots
81.3
7.4
8
*
ZX013
NOMESCO Finland
Radiotherapy with large shaped fields - SSD therapy
11.1
7.3
13
12
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.0
7.3
32
111
NA1DG
NOMESCO Finland
Cervical spine very extensive MRI examination with high intensity magnet
+∞
7.3
7
*
M49.0
ICD-10 Finland
Tuberculosis of spine
+∞
7.3
7
*
9211
FHL
Exploration or removal of diskusprolapse
+∞
7.3
7
*
NAG42
NOMESCO Finland
Posterior fusion of cervical spine with or without fixation
+∞
7.3
7
*
ABC60
NOMESCO Finland
Decompression of cervical spinal cord
+∞
7.3
7
*
M49
ICD-10 Finland
Spondylopathies in diseases classified elsewhere
+∞
7.3
7
*
H02AB07
ATC
prednisone; oral
2.1
7.3
70
354
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.1
7.3
75
390
TKC22
NOMESCO Finland
Catheterisation instruction
4.4
7.3
18
42
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
3.0
7.3
33
117
379
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the long-term prevention of recurrent deep veinthrombosis and pulmonary embolism
3.6
7.2
24
70
322
Kela drug reimbursment
Sunitinib
30.5
7.2
9
*
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
8.1
7.2
15
19
D70.82
ICD-10 Finland
Drug-induced neutropenia
6.2
7.1
18
30
R60.0
ICD-10 Finland
Localized oedema
2.1
7.1
69
351
M01AH01
ATC
celecoxib; oral
2.0
7.1
79
423
L02AE04
ATC
triptorelin; parenteral
6.5
7.0
17
27
8310/3-C64.9
ICD-O-3
Clear cell adenocarcinoma, NOS, of kidney, NOS
6.0
7.0
18
31
A41.9
ICD-10 Finland
Sepsis, unspecified
3.2
7.0
27
87
L01EX07
ATC
cabozantinib; oral
14.0
6.9
11
8
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.7
6.9
205
1478
A01
ICPC
Pain general/multiple sites
2.4
6.8
48
213
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.5
6.8
44
188
M45
ICD-10 Finland
Ankylosing spondylitis
40.6
6.8
8
*
M41.5
ICD-10 Finland
Other secondary scoliosis
40.6
6.8
8
*
3060, ,
Kela drug reimbursment
40.6
6.8
8
*
L01FC01
ATC
daratumumab; parenteral
40.6
6.8
8
*
WGA11
NOMESCO Finland
Planning of pain management
17.0
6.8
10
6
M54
ICD-10 Finland
Dorsalgia
2.4
6.7
45
195
S22.3
ICD-10 Finland
Fracture of rib
2.5
6.7
41
170
R5110, ,
SPAT
2.3
6.7
51
234
NA1BA
NOMESCO Finland
Cervical spine extensive X-ray examination without contrast
22.9
6.7
9
*
M80.8
ICD-10 Finland
Other osteoporosis with pathological fracture
22.9
6.7
9
*
J94.8
ICD-10 Finland
Other specified pleural conditions
5.6
6.7
18
33
A02BC05
ATC
esomeprazole; systemic
1.7
6.7
178
1246
M47.82
ICD-10 Finland
Other spondylosis, cervical region
8.0
6.7
14
18
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.1
6.7
65
331
R4110
NOMESCO Finland
Physiotherapy
1.8
6.6
133
861
R33
ICD-10 Finland
Retention of urine
2.3
6.6
54
256
K08.3
ICD-10 Finland
Retained dental root
2.5
6.6
42
178
HAC20
NOMESCO Finland
Total mastectomy
3.2
6.6
26
85
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.8
6.5
118
742
L01EF03
ATC
abemaciclib; oral
70.8
6.4
7
*
ABC63
NOMESCO Finland
Decompression of thoracic spinal cord
70.8
6.4
7
*
M01AE01
ATC
ibuprofen; systemic, rectal
1.9
6.4
398
3456
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.7
6.4
130
842
L29
ICPC
Musculoskeletal sympt/complt other
2.4
6.4
44
193
Z3226
NOMESCO Finland
Physiotherapist
1.9
6.4
83
468
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.8
6.4
32
120
EB1AI
NOMESCO Finland
Cone beam imaging of teeth and jaws (one quarter)
6.7
6.4
15
23
G04BD04
ATC
oxybutynin; oral, transdermal
2.6
6.4
36
144
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.3
6.3
48
220
L02BA01
ATC
tamoxifen; oral
3.1
6.3
26
87
G55.2*M47.9
ICD-10 Finland
Nerve root and plexus compressions in spondylosis
18.3
6.3
9
5
AB5BT
NOMESCO Finland
Blockage of nerv root with X-ray guidance
+∞
6.3
6
*
L01XG03
ATC
ixazomib; oral
+∞
6.3
6
*
NAG41
NOMESCO Finland
Anterior fusion of cervical spine with fixation
+∞
6.3
6
*
ABC26
NOMESCO Finland
Open discectomy of lumbar spine
+∞
6.3
6
*
M49.1*A23.9
ICD-10 Finland
Brucella spondylitis
+∞
6.3
6
*
M46.9
ICD-10 Finland
Inflammatory spondylopathy, unspecified
+∞
6.3
6
*
G55.1*M51.1
ICD-10 Finland
Compression of nerve roots and nerve plexus in disc diseases in the lumbar region and other regions
27.1
6.2
8
*
XKD00
NOMESCO Finland
Uroflowmetry
1.8
6.2
97
581
R1250
NOMESCO Finland
Evaluation of functional capability
4.1
6.2
17
43
U04
ICPC
Incontinence urine
2.5
6.2
38
158
M79.0
ICD-10 Finland
Rheumatism, unspecified
5.9
6.2
16
28
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.3
6.2
47
216
ZXD35
NOMESCO Finland
Usual procedure
3.9
6.1
18
48
B99
ICD-10 Finland
Other and unspecified infectious diseases
4.2
6.1
16
39
G82.2
ICD-10 Finland
Paraplegia, unspecified
12.7
6.1
10
8
PJ2AT
NOMESCO Finland
Biopsy of lymphnode with ultrasound guidance
10.2
6.1
11
11
A04AA55
ATC
palonosetron, combinations; systemic
3.1
6.0
25
84
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.0
6.0
27
95
M81.9
ICD-10 Finland
Osteoporosis, unspecified
3.0
6.0
27
95
N05AD01
ATC
haloperidol; systemic
3.1
6.0
24
79
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
113
150
9.54
83.91
23.9
2.7
70.34
99.81
mg/l
0.29
104
126
112
150
9.43
82.51
24.1
2.7
28.31
63.56
mg/l
0.89
103
128
108
142
9.52
80.66
22.0
2.4
20.49
2.76
ratio
0.58
82
77
192
554
5.11
64.07
10.2
4.6
244.90
247.62
u/l
0.11
187
525
149
384
5.18
56.18
19.4
2.3
64.78
66.61
g/l
1.87
141
357
210
758
4.15
50.34
3.2
1.8
—
—
—
0
0
197
716
3.97
46.08
6.5
3.2
0.79
0.81
mmol/l
2.23
187
678
380
2197
4.50
43.25
26.6
7.1
1.21
1.21
mmol/l
0.30
339
1864
82
171
5.58
38.55
19.6
1.7
4.26
1.52
g/l
1.83
70
147
345
1968
3.68
37.63
21.2
6.3
1.21
1.21
mmol/l
0.76
332
1806
113
314
4.40
37.56
9.9
2.9
10.58
11.10
g/l
0.23
108
287
56
83
7.51
36.88
7.2
5.2
321.80
340.70
iu/ml
—
5
10
159
570
3.68
36.78
2.8
1.8
—
—
—
0
0
37
35
11.37
34.39
6.4
2.7
329.97
960.14
mg
1.91
37
35
74
159
5.32
33.48
21.2
1.3
8.55
11.43
g/l
2.61
68
140
144
534
3.42
30.97
2.9
1.8
—
—
—
0
0
63
128
5.51
30.24
2.2
1.6
—
—
—
0
0
61
122
5.58
29.78
2.1
1.6
—
—
—
0
0
38
49
8.34
28.04
1.9
1.8
—
—
—
0
0
152
616
3.15
27.86
8.9
5.6
1.01
1.05
mmol/l
0.64
139
565
37
48
8.27
27.15
1.9
1.8
—
—
—
0
0
355
2308
3.07
26.29
34.6
9.8
3.69
4.19
e9/l
4.57
334
1986
35
45
8.31
25.85
2.9
2.9
—
—
—
0
0
132
514
3.16
25.67
7.4
7.7
0.90
1.02
mmol/l
0.11
105
429
314
1931
2.81
25.50
17.1
4.8
32.95
34.83
g/l
6.75
298
1792
130
505
3.16
25.35
7.6
7.8
12.50
11.95
kpa
0.53
120
494
130
505
3.16
25.35
7.6
7.8
5.17
5.12
kpa
0.18
120
494
46
82
6.10
25.25
2.1
1.8
—
—
—
0
0
263
1486
2.70
25.19
9.4
3.7
2.32
2.35
mmol/l
2.22
250
1337
62
148
4.66
24.55
19.7
1.3
0.02
0.00
g/l
0.49
53
129
95
314
3.53
23.99
2.3
1.5
—
—
—
0
0
56
130
4.74
22.91
1.9
1.3
—
—
—
0
0
231
1278
2.56
22.33
4.0
2.4
46.90
69.04
u/l
3.63
221
1177
37
60
6.60
22.24
1.6
1.5
—
—
—
0
0
361
2479
2.84
22.05
12.5
4.9
6.78
6.79
mmol/l
0.02
346
2362
57
140
4.49
21.72
21.2
1.3
0.00
0.00
g/l
-0.00
47
120
325
2131
2.63
21.59
13.8
16.6
1.24
1.32
inr
2.13
277
1775
70
208
3.77
20.59
1.7
1.3
—
—
—
0
0
293
1858
2.48
20.45
4.9
2.7
—
—
estimate
—
0
0
374
2674
2.81
20.03
7.9
4.4
41.40
1805.15
e6/l
—
5
59
30
44
7.21
19.75
2.2
1.5
—
—
—
0
0
30
44
7.21
19.75
2.2
1.5
—
—
—
0
0
30
44
7.21
19.75
2.2
1.5
—
—
—
0
0
80
277
3.27
18.53
5.3
6.5
25.28
24.68
mmol/l
0.63
72
269
105
435
2.81
17.69
8.0
8.6
112.44
119.84
g/l
3.34
99
430
24
31
8.10
17.57
2.3
3.3
29.08
38.73
%
0.95
12
15
68
220
3.44
17.52
2.0
1.8
1.03
2.64
ug/l
0.64
58
199
181
998
2.31
16.45
4.3
2.4
—
—
—
0
0
22
9
25.52
16.14
1.2
2.6
—
—
—
0
0
256
1655
2.17
15.42
5.2
3.8
37.74
102.87
ng/l
0.86
215
1302
174
989
2.19
14.31
3.7
2.6
5.24
5.95
e6/l
0.25
163
905
98
440
2.54
13.83
8.5
6.4
10.22
10.64
mmol/l
0.23
91
418
206
1269
2.09
13.59
2.7
2.1
132.97
312.13
u/l
1.98
187
1192
137
721
2.26
13.50
3.4
1.9
28.26
29.53
s
2.38
132
701
101
465
2.48
13.49
6.4
3.5
5.92
5.77
kpa
0.56
101
448
112
545
2.38
13.22
4.8
4.6
16.90
32.44
ug/l
0.44
89
447
178
1051
2.10
13.03
9.1
2.9
316.83
363.26
umol/l
4.65
164
916
391
3112
2.38
12.54
29.0
8.3
91.49
82.89
u/l
1.81
384
2925
73
297
2.72
12.50
2.3
1.6
—
—
—
0
0
221
1430
2.01
12.45
5.4
3.3
28.18
115.79
e6/l
1.19
195
1100
31
73
4.47
12.38
1.7
1.2
—
—
—
0
0
31
73
4.47
12.38
1.7
1.2
—
—
—
0
0
226
1478
2.00
12.31
3.8
3.2
1262.44
1691.74
ng/l
1.43
201
1295
206
1308
2.01
12.17
6.4
3.2
55.33
34.62
u/l
0.98
199
1233
29
67
4.54
11.86
1.4
1.2
—
—
—
0
0
68
275
2.72
11.76
3.9
3.8
1.77
2.52
mmol/l
0.81
53
206
94
448
2.37
11.52
6.6
3.5
2.06
1.71
mmol/l
0.34
85
371
192
1210
1.98
11.41
5.2
3.2
0.28
0.59
e6/l
2.14
170
891
36
105
3.63
10.79
1.8
1.5
—
—
—
0
0
92
1652
0.45
10.75
2.0
1.9
1.65
1.28
mmol/l
1.14
81
1333
21
40
5.44
10.68
1.3
1.8
21.74
50.67
ng/l
0.51
21
40
21
23
9.49
10.61
2.4
1.5
—
—
—
0
0
21
23
9.49
10.61
2.4
1.5
—
—
—
0
0
21
23
9.49
10.61
2.4
1.5
—
—
—
0
0
21
23
9.49
10.61
2.4
1.5
—
—
—
0
0
145
853
2.00
10.31
6.3
3.2
2.48
2.46
mmol/l
0.63
134
771
19
19
10.36
10.10
2.5
1.5
—
—
—
0
0
19
19
10.36
10.10
2.8
1.5
—
—
—
0
0
19
19
10.36
10.10
2.5
1.5
—
—
—
0
0
232
1606
1.86
10.02
6.3
3.8
82.93
149.87
e6/l
0.66
197
1138
46
164
3.00
10.01
3.8
4.3
24.83
25.15
mmol/l
0.24
40
153
94
474
2.22
10.00
6.8
2.5
7.74
8.58
umol/l
0.23
87
421
46
168
2.92
9.59
3.8
1.7
—
—
—
0
0
32
94
3.58
9.49
1.7
1.5
—
—
—
0
0
81
393
2.28
9.43
5.7
2.9
4.49
4.53
kpa
0.07
81
380
282
2110
1.82
9.14
6.2
3.7
26.23
0.01
estimate
0.49
62
458
45
167
2.87
9.12
3.1
2.7
—
—
—
0
0
278
2079
1.80
8.94
6.1
3.7
0.00
0.00
estimate
-0.00
60
455
46
176
2.78
8.81
1.8
3.7
201.96
153.30
u/ml
0.15
46
169
50
201
2.66
8.71
5.0
4.5
1.70
1.49
%
1.07
44
196
280
2112
1.78
8.62
6.2
3.7
0.00
0.71
estimate
0.51
59
428
173
1135
1.82
8.55
2.3
2.1
3.42
2.95
mg/l
1.15
158
962
18
37
5.02
8.42
1.2
1.4
—
—
—
0
0
30
92
3.41
8.35
1.8
1.5
—
—
—
0
0
24
63
3.96
8.34
1.9
1.7
—
—
—
0
0
24
64
3.89
8.17
1.3
1.2
295.50
341.65
u/ml
0.20
12
26
41
154
2.82
8.13
2.8
1.6
—
—
—
0
0
34
115
3.11
8.10
1.9
1.3
—
—
—
0
0
53
231
2.46
7.82
7.8
4.0
52.76
46.46
%
1.16
53
223
35
124
2.97
7.71
1.4
1.7
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
39
147
2.80
7.69
2.8
2.4
0.34
0.42
iu/ml
0.66
28
81
12
9
13.63
7.42
12.5
4.6
—
—
—
0
0
17
38
4.60
7.23
1.3
1.1
—
—
—
0
0
25
75
3.46
7.20
1.5
1.4
—
—
—
0
0
128
802
1.81
7.17
2.4
1.6
1.22
1.50
mg/l
0.68
103
647
18
31
5.99
6.98
1.1
1.2
—
—
—
0
0
12
11
11.15
6.83
1.0
1.1
—
—
—
0
0
254
1948
1.65
6.65
3.5
2.5
—
—
—
0
0
30
110
2.84
6.24
1.7
1.4
226.22
276.09
ug/g
0.59
21
74
61
312
2.09
6.17
2.9
2.4
4.09
12.52
nmol/l
14.03
54
284
24
78
3.19
6.13
1.6
1.6
—
—
—
0
0
19
53
3.69
6.09
1.3
1.4
9685.09
22500.89
e6/l
0.57
11
27
109
684
1.77
5.97
5.2
3.1
3.31
2.20
e6/l
0.47
70
333
168
1187
1.64
5.92
6.5
3.7
0.00
0.01
estimate
0.78
53
404
114
729
1.74
5.84
4.7
3.0
1.20
1.22
e6/l
0.04
75
378
20
60
3.43
5.78
1.3
1.4
684.27
1532.68
e6/l
1.48
15
37
25
89
2.91
5.49
1.5
1.3
—
—
—
0
0
9
8
11.43
5.31
2.1
1.5
—
—
—
0
0
13
22
6.04
5.25
1.5
1.3
116.62
84.24
u/l
0.30
13
17
16
44
3.73
5.24
2.8
3.7
3.12
3.83
nmol/l
0.33
16
44
44
212
2.18
5.18
7.5
3.5
25.54
25.08
mmol/l
0.36
44
204
228
1773
1.54
5.17
3.6
2.8
282.55
146.75
ug/l
2.47
220
1623
125
845
1.65
5.15
5.2
3.6
55.40
380.29
ng/l
4.37
107
705
64
356
1.92
5.13
2.8
3.1
133.89
233.97
ng/l
2.57
56
331
14
27
5.31
5.12
2.9
1.3
—
—
—
0
0
14
27
5.31
5.12
2.9
1.3
—
—
—
0
0
13
23
5.78
5.09
3.0
1.5
—
—
—
0
0
19
60
3.26
5.09
2.1
1.7
—
—
—
0
0
13
24
5.54
4.94
9.4
2.2
39.15
41.40
g/l
0.82
13
24
29
119
2.53
4.89
4.6
3.1
2.41
2.04
index
0.13
17
67
20
67
3.07
4.88
4.1
2.5
33.80
32.66
pg
0.77
20
67
12
21
5.83
4.78
1.4
1.3
22.83
27.60
u/l
0.17
12
15
12
22
5.57
4.63
3.2
1.4
—
—
—
0
0
12
22
5.57
4.63
3.2
1.4
—
—
—
0
0
202
1561
1.51
4.54
6.9
3.7
9.43
0.03
estimate
0.49
53
365
16
49
3.34
4.50
2.1
1.4
—
—
—
0
0
16
49
3.34
4.50
2.1
1.4
—
—
—
0
0
16
49
3.34
4.50
2.1
1.4
—
—
—
0
0
340
2930
1.55
4.50
7.1
4.1
21.68
14.18
mm/h
7.38
321
2672
16
50
3.28
4.37
2.1
1.4
—
—
—
0
0
16
50
3.28
4.37
2.2
1.4
—
—
—
0
0
16
50
3.28
4.37
2.2
1.4
—
—
—
0
0
28
121
2.40
4.26
4.2
1.6
94.75
92.48
%
0.26
28
116
14
34
4.21
4.24
1.5
1.0
—
—
—
0
0
52
290
1.89
4.14
6.3
2.9
118.29
126.52
g/l
1.72
52
280
63
377
1.77
4.01
2.8
2.2
5.38
7.50
ug/l
0.51
53
331
112
781
1.57
3.97
2.0
1.7
1144.69
1162.26
nmol/l
0.06
94
585
14
43
3.32
3.93
1.6
1.4
—
—
—
0
0
26
114
2.35
3.85
4.4
1.9
214.69
209.90
%
0.11
26
109
122
881
1.52
3.67
7.6
3.9
1.02
1.02
kg/l
0.65
101
585
22
92
2.46
3.61
1.4
1.6
—
—
—
0
0
14
46
3.10
3.55
1.7
1.6
—
—
—
0
0
38
202
1.96
3.50
3.0
4.1
184.37
1600.37
u/ml
0.92
30
171
6
6
10.10
3.50
1.5
1.0
—
—
—
0
0
219
1786
1.42
3.45
2.9
2.3
75.84
78.62
nmol/l
0.67
200
1570
10
22
4.62
3.44
2.2
4.0
2.10
1.55
%
—
10
22
29
141
2.12
3.39
4.7
3.3
8.57
8.07
kpa
0.84
29
135
10
23
4.42
3.32
1.2
2.4
—
—
—
0
0
414
3820
1.61
3.23
52.7
16.3
31.41
28.08
mg/l
1.32
400
3182
16
61
2.68
3.16
1.2
1.2
—
—
—
0
0
9
20
4.56
3.12
1.1
1.1
—
—
—
0
0
55
341
1.69
3.11
3.6
3.9
111.96
94.74
ng/l
0.47
49
294
6
8
7.58
3.06
1.0
1.3
—
—
—
0
0
343
3742
0.71
2.84
6.2
6.9
40.57
39.90
mmol/mol
0.71
320
3436
354
3840
0.70
2.82
4.5
5.2
4.52
4.49
mmol/l
0.13
325
3506
19
84
2.31
2.81
1.6
1.5
—
—
—
0
0
363
3911
0.71
2.64
4.9
6.0
2.62
2.60
mmol/l
0.18
329
3548
163
1313
1.37
2.60
1.9
1.7
17.27
19.89
nmol/l
1.61
150
1084
9
25
3.65
2.58
1.0
1.1
—
—
—
0
0
353
3817
0.72
2.58
4.5
5.1
1.39
1.46
mmol/l
2.46
322
3458
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
8
20
4.05
2.57
1.1
1.2
—
—
—
0
0
18
81
2.27
2.57
1.2
1.3
15.36
54.10
e6/l
0.43
11
60
18
82
2.24
2.50
1.2
1.4
79.33
64.62
e6/l
0.10
12
63
8
21
3.86
2.47
1.0
1.3
—
—
—
0
0
55
370
1.55
2.28
3.7
2.3
25.13
45.04
u/l
0.98
47
318
17
80
2.17
2.21
4.6
2.5
7.29
8.55
pmol/l
0.21
17
80
18
88
2.09
2.14
1.3
1.2
—
—
—
0
0
139
1125
1.33
2.09
6.3
3.4
0.49
0.12
estimate
0.35
53
325
338
3646
0.75
2.07
4.2
4.4
1.36
1.25
mmol/l
2.75
308
3270
66
476
1.45
1.98
15.0
6.6
—
—
—
0
0
6
16
3.78
1.94
1.3
1.4
—
—
—
0
0
20
107
1.91
1.89
1.2
1.3
—
—
—
0
0
20
107
1.91
1.89
1.2
1.4
—
—
—
0
0
7
22
3.21
1.88
2.7
3.2
—
—
—
0
0
279
2504
1.27
1.84
4.1
3.1
60.43
54.94
u/l
0.44
258
2313
5
12
4.20
1.82
1.0
1.1
—
—
—
0
0
17
87
1.99
1.82
1.3
1.2
—
—
—
0
0
10
40
2.53
1.67
2.1
1.8
—
—
—
0
0
6
19
3.18
1.66
3.0
2.7
224.83
208.89
u/l
—
6
19
44
307
1.48
1.59
5.8
2.9
63.67
57.05
ml/min/173m2
0.76
27
130
6
21
2.88
1.51
1.0
1.6
—
—
—
0
0
14
73
1.95
1.45
1.3
1.3
—
236.17
—
0
31
9
39
2.33
1.43
1.0
1.4
—
—
—
0
0
10
46
2.20
1.40
1.5
1.7
—
—
—
0
0
5
17
2.96
1.36
1.2
1.1
—
—
—
0
0
5
17
2.96
1.36
2.4
1.5
—
—
—
0
0
11
56
1.99
1.23
1.0
1.1
1.59
1.54
g/l
0.22
11
50
61
477
1.32
1.18
5.6
3.3
—
—
—
0
0
94
778
1.26
1.18
1.2
1.3
1.03
1.52
u/ml
0.53
28
193
21
134
1.59
1.16
6.0
3.2
1.49
1.68
mg/l
0.65
21
124
8
39
2.07
1.15
1.3
1.2
103.25
99.74
pmol/l
—
8
39
366
3833
0.81
1.15
5.3
5.4
6.08
6.05
mmol/l
0.14
334
3435
22
143
1.56
1.13
1.4
2.2
7.86
9.95
iu/ml
—
7
33
7
32
2.20
1.08
5.0
2.2
0.86
0.97
index
—
7
32
214
1940
1.19
1.07
2.4
2.1
85.33
95.74
pmol/l
2.70
143
1004
55
432
1.31
1.04
1.3
1.4
—
—
—
0
0
9
46
1.97
1.04
2.6
3.7
—
—
—
0
0
7
34
2.07
1.03
1.0
1.0
—
—
—
0
0
9
47
1.93
1.02
1.0
1.0
—
19.82
—
0
12
133
1512
0.83
1.01
3.5
3.5
7.37
7.38
mmol/l
0.01
112
1256
5
23
2.19
0.98
1.2
1.0
—
—
—
0
0
7
37
1.90
0.94
2.0
1.6
—
—
—
0
0
6
27
2.24
0.93
1.3
1.6
—
—
—
0
0
6
27
2.24
0.93
1.3
1.6
—
—
—
0
0
6
27
2.24
0.93
2.2
2.5
20.33
38.95
mg/l
—
6
20
29
211
1.40
0.90
1.1
1.2
19.93
154.31
u/ml
—
8
76
18
121
1.51
0.84
2.2
1.5
—
—
—
0
0
12
73
1.66
0.82
1.0
1.1
—
2.69
—
0
9
309
2924
1.16
0.82
5.6
4.1
14.97
15.06
pmol/l
0.23
291
2619
135
1508
0.85
0.82
4.1
4.3
14.16
9.00
mg/mmol
0.59
92
955
6
32
1.89
0.82
1.2
1.1
279.17
266.85
mg/l
—
6
26
17
114
1.51
0.80
1.3
1.7
—
—
—
0
0
5
24
2.09
0.74
1.2
1.0
—
—
—
0
0
5
24
2.09
0.74
1.2
1.1
—
—
—
0
0
19
133
1.45
0.74
1.3
1.3
—
—
—
0
0
7
38
1.85
0.74
2.4
1.8
—
—
—
0
0
5
25
2.01
0.73
1.2
1.0
—
—
—
0
0
5
25
2.01
0.73
1.2
1.0
—
—
—
0
0
7
39
1.81
0.72
1.0
1.1
—
—
—
0
0
107
944
1.17
0.72
2.1
1.8
434.27
20523297.86
pmol/l
1.06
95
765
21
151
1.41
0.72
1.0
1.1
—
—
—
0
0
7
43
1.64
0.67
1.0
1.1
—
1.00
—
0
6
46
556
0.81
0.67
1.2
1.2
1.31
14.37
u/ml
2.98
14
188
5
28
1.79
0.66
1.2
1.0
—
—
—
0
0
5
29
1.73
0.64
1.2
1.1
—
—
—
0
0
16
113
1.43
0.62
2.4
2.4
81.49
74.28
ug/min
0.04
11
59
11
72
1.54
0.59
1.3
1.3
—
—
—
0
0
6
38
1.59
0.54
1.3
1.4
0.15
0.19
nmol/l
—
6
29
181
1688
1.12
0.54
9.7
5.8
23.23
2.82
ug/l
1.21
167
1505
6
99
0.60
0.52
1.0
1.5
—
—
—
0
0
14
101
1.40
0.50
3.0
1.7
57.00
62.70
%
0.38
14
101
40
339
1.20
0.46
1.5
1.4
—
—
—
0
0
14
103
1.37
0.45
1.8
1.3
—
—
—
0
0
5
31
1.62
0.43
2.2
1.7
—
—
—
0
0
5
32
1.57
0.42
2.2
1.7
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
294
3035
0.92
0.38
65.6
22.1
328.67
331.55
g/l
5.09
294
3018
144
1352
1.09
0.37
7.6
4.6
19.31
21.97
%
1.72
88
713
52
584
0.88
0.36
4.6
5.2
32.32
32.22
%
0.03
38
374
5
78
0.64
0.36
1.2
1.6
—
—
—
0
0
93
987
0.93
0.24
4.1
3.3
0.87
0.84
ug/l
0.10
73
702
10
79
1.27
0.22
1.4
1.3
—
76.67
—
0
6
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
12
0.00
0.21
0.0
1.8
—
99.67
—
0
12
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
54.67
—
0
12
0
13
0.00
0.21
0.0
1.7
—
—
—
0
0
382
3769
1.07
0.20
44.9
16.9
77.30
75.24
ml/min/173m2
1.10
362
3494
416
4118
1.08
0.19
64.0
22.5
82.77
81.94
umol/l
0.12
411
4057
10
81
1.24
0.19
1.0
1.1
—
16.97
—
0
11
39
415
0.93
0.12
1.5
1.5
—
—
—
0
0
11
97
1.14
0.09
1.5
1.2
—
—
—
0
0
6
75
0.80
0.07
3.3
1.8
233.17
199.75
pmol/l
—
6
68
9
88
1.02
0.07
2.9
1.8
31.11
41.91
nmol/l
—
9
82
408
4063
1.03
0.05
35.2
12.2
24.84
24.81
u/l
0.02
402
3915
36
347
1.04
0.05
1.6
1.8
1.62
1.58
%
0.14
29
292
12
128
0.94
0.02
2.4
1.4
0.36
0.37
mg/l
—
6
56
416
4166
0.99
0.00
71.8
25.3
4.09
4.44
e12/l
26.24
411
4035
15
154
0.97
0.00
1.1
1.6
—
—
—
0
0
17
167
1.02
0.00
1.3
1.7
—
—
—
0
0
61
608
1.00
0.00
1.3
1.2
14.08
39.03
iu/ml
4.35
14
192
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
20.50
—
0
5
0
5
0.00
0.00
0.0
2.0
—
116.80
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
4.2
—
112.02
—
0
5
358
3580
1.00
-0.00
6.5
5.0
2.06
2.02
mu/l
0.16
328
3210
5
56
0.89
-0.00
1.0
1.2
—
64.70
—
0
10
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
8.57
—
0
6
0
7
0.00
-0.00
0.0
5.9
—
10.43
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
0.13
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
1.19
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
86.33
—
0
6
0
6
0.00
-0.00
0.0
2.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.7
—
0.50
—
0
6
5
51
0.98
-0.00
1.2
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
19.39
—
0
7
Mortality – FinRegistry
↥Association
Association between endpoint M13_SPONDYLOPATHINOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SPONDYLOPATHINOTH | 5.167 [4.07, 6.56] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.863 |
During the follow-up period (1.1.1998 — 31.12.2019), 652 out of 1121 females with M13_SPONDYLOPATHINOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SPONDYLOPATHINOTH | 5.293 [4.03, 6.95] | < 0.001 |
| Birth year | 0.985 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 776 out of 1200 males with M13_SPONDYLOPATHINOTH died.
Mortality risk
Mortality risk for people of age
years, who have M13_SPONDYLOPATHINOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.484% | 0.855% |
| 5 | 3.033% | 5.448% |
| 10 | 7.674% | 13.902% |
| 15 | 14.248% | 24.854% |
| 20 | 24.02% | 38.395% |
Relationships between endpoints
↥Index endpoint: M13_SPONDYLOPATHINOTH – Spondylopathies in diseases classified elsewhere
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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