osteitis deformans: A disease of bone that initially results in the excessive resorption of bone (by osteoclasts) followed by the replacement of normal bone marrow with vascular and fibrous tissue.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
190 |
4. Check minimum number of eventsNone |
190 |
5. Include endpointsNone |
190 |
6. Filter based on genotype QC (FinnGen only) |
176 |
Control definitions (FinnGen only)
- Control exclude
- M13_OSTEOCHONDRO
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M86-M90
- Name in latin
- Osteitis deformans Paget
Similar endpoints
↥List of similar endpoints to
Paget disease
based on the number of shared cases.
Similar with more cases:
- Osteopathies and chondropathies
- Diseases of the musculoskeletal system and connective tissue
- Any operation in hilmo
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1125 | 513 | 598 |
| Only index persons | 891 | 427 | 464 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.01 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 66.25 | 66.30 | 66.15 |
| Only index persons | 64.97 | 63.99 | 65.87 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 176 | 77 | 99 |
| Unadjusted period prevalence (%) | 0.04 | 0.03 | 0.05 |
| Median age at first event (years) | 66.05 | 65.13 | 66.77 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 183
- Matched controls
- 1830
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M88.9
ICD-10 Finland
Paget disease of bone, unspecified
+∞
133.1
111
*
M88.88
ICD-10 Finland
Paget disease of other bones, other
+∞
99.2
86
*
M88.0
ICD-10 Finland
Paget disease of skull
+∞
25.6
24
*
M88
ICD-10 Finland
Paget disease of bone [osteitis deformans]
+∞
18.0
17
*
D48.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage
18.6
15.2
23
14
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.3
14.0
97
471
7310A
ICD-9 Finland
Osteitis deformans and osteopathies associated with other disorders classified elsewhere, Osteitis deformans without mention of bone tumour
+∞
12.6
12
*
ZX120
NOMESCO Finland
Intravenous
4.1
12.4
39
113
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.9
11.0
36
107
NK6AN
NOMESCO Finland
Total body bone isotope imaging
9.2
9.9
20
24
NK6BN
NOMESCO Finland
Bone dynamic isotope examination
94.2
8.5
9
*
NF1AA
NOMESCO Finland
Hip X-ray examination
3.3
7.8
33
115
72199
ICD-8 Finland
Osteitis deformans
+∞
7.3
7
*
M79.0
ICD-10 Finland
Rheumatism, unspecified
8.5
7.3
15
19
NE1AA
NOMESCO Finland
Pelvis X-ray examination
3.3
7.3
30
103
Q78.1
ICD-10 Finland
Polyostotic fibrous dysplasia
+∞
6.3
6
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
6.2
54
273
N02AX02
ATC
tramadol; systemic, rectal
2.2
6.2
94
600
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
41
20
26.13
55.57
2.0
1.2
—
—
—
0
0
86
215
6.66
35.89
4.8
5.7
0.99
1.05
mmol/l
1.16
81
202
54
122
5.86
24.12
2.8
4.1
72.21
88.11
ng/l
0.89
47
105
147
863
4.58
16.64
10.1
6.5
1.22
1.21
mmol/l
1.92
131
751
15
0
+∞
15.85
1.4
0.0
—
—
—
0
0
118
729
2.74
9.70
6.6
4.4
35.74
34.75
g/l
1.12
110
678
130
889
2.60
7.96
10.8
9.8
3.98
4.10
e9/l
0.26
111
766
18
29
6.76
7.46
3.7
3.3
7.15
13.19
pmol/l
0.98
18
29
26
83
3.49
7.03
2.5
1.3
6.98
7.58
g/l
1.37
26
78
26
83
3.49
7.03
2.5
1.3
4.20
4.46
g/l
0.50
26
78
26
83
3.49
7.03
2.5
1.3
3.48
4.07
g/l
0.78
26
78
92
561
2.29
6.99
4.5
3.3
2.35
2.35
mmol/l
0.21
84
505
24
75
3.53
6.70
1.5
1.3
8.99
10.66
g/l
1.37
24
69
79
464
2.24
6.45
2.5
2.1
2.92
2.75
mg/l
0.30
70
411
24
79
3.35
6.18
2.6
1.3
2.74
3.02
g/l
1.01
24
74
144
1102
2.44
5.86
4.9
4.1
15.23
15.01
pmol/l
0.58
138
983
122
879
2.16
5.65
7.3
6.5
10.49
11.87
umol/l
1.17
114
828
19
63
3.25
4.83
2.5
3.4
9.42
3.31
ratio
0.32
11
26
20
69
3.13
4.77
2.6
3.9
73.13
138.64
mg/l
0.31
15
58
20
69
3.13
4.77
2.6
3.9
34.10
34.45
mg/l
0.01
15
59
167
1422
2.99
4.56
27.3
18.0
72.42
74.10
ml/min/173m2
0.43
160
1321
144
1150
2.18
4.54
6.6
4.4
14.83
14.01
mm/h
0.21
133
1055
69
434
1.95
4.34
3.3
3.0
379.63
357.24
umol/l
0.81
62
373
120
913
1.91
4.14
3.4
3.1
53.06
49.75
u/l
0.10
108
841
100
720
1.86
4.08
3.1
2.7
—
—
estimate
—
0
0
25
112
2.43
3.68
1.6
1.9
—
—
—
0
0
30
150
2.20
3.45
3.1
2.4
0.27
0.52
e6/l
0.39
30
143
27
130
2.26
3.39
2.9
3.2
62.91
60.67
ml/min/173m2
0.09
16
58
167
1469
2.56
3.38
25.8
17.4
22.75
26.67
mg/l
0.97
150
1236
14
48
3.08
3.38
2.7
2.1
1.88
1.71
mg/l
0.33
14
40
57
363
1.83
3.32
4.9
3.1
2.44
2.46
mmol/l
0.71
50
323
61
400
1.79
3.22
2.6
2.4
—
—
—
0
0
171
1529
2.81
3.19
30.6
21.5
139.78
139.66
mmol/l
0.26
171
1496
171
1532
2.77
3.12
30.9
21.7
4.00
4.01
mmol/l
0.29
171
1500
170
1528
2.58
2.91
17.9
12.6
23.77
24.86
u/l
0.55
165
1476
171
1546
2.62
2.79
36.9
24.0
90.13
84.13
umol/l
0.65
171
1526
84
624
1.64
2.72
3.4
3.1
1804.16
1399.12
ng/l
0.44
71
534
92
701
1.63
2.68
4.4
4.2
25.61
41.22
ng/l
1.89
75
567
47
300
1.76
2.67
3.6
3.2
2.81
1.78
e6/l
0.30
28
157
107
853
1.61
2.55
5.4
4.0
0.00
0.00
estimate
-0.00
25
188
155
1364
1.89
2.51
7.2
5.2
1.82
2.00
mu/l
1.19
148
1225
171
1560
2.47
2.48
40.5
26.8
91.75
91.80
fl
0.06
171
1541
171
1560
2.47
2.48
41.0
27.4
40.18
39.76
%
0.62
171
1541
171
1561
2.46
2.45
40.9
27.0
132.32
133.53
g/l
0.49
171
1541
47
308
1.71
2.42
2.3
1.8
—
—
—
0
0
162
1452
2.01
2.39
6.7
6.4
2.61
2.54
mmol/l
0.35
151
1334
105
842
1.58
2.37
5.4
4.0
0.00
0.00
estimate
-0.00
25
187
69
503
1.60
2.34
2.9
2.4
63.36
74.55
u/l
0.39
64
456
12
47
2.66
2.32
1.0
1.2
—
—
—
0
0
10
36
2.88
2.17
1.4
1.2
—
—
—
0
0
47
319
1.64
2.11
4.0
3.1
0.89
0.86
e6/l
0.03
29
172
105
858
1.53
2.07
5.5
4.0
0.00
0.02
estimate
0.50
21
172
6
15
4.10
2.05
1.3
1.2
—
—
—
0
0
40
262
1.67
2.05
1.4
1.3
23.29
35.60
iu/ml
0.57
11
88
9
33
2.81
1.96
1.9
1.2
—
—
—
0
0
6
16
3.84
1.95
1.0
1.0
—
—
—
0
0
67
504
1.52
1.92
4.4
3.4
0.43
0.33
e6/l
0.15
53
373
5
12
4.25
1.83
1.2
1.2
—
—
—
0
0
5
12
4.25
1.83
1.2
1.2
—
—
—
0
0
158
1437
1.73
1.77
6.2
5.7
6.07
6.12
mmol/l
0.21
143
1313
6
18
3.41
1.76
8.2
3.9
243.50
1208.00
mg
—
6
18
5
13
3.92
1.72
1.6
1.0
—
—
—
0
0
35
233
1.62
1.68
2.4
1.8
—
—
—
0
0
71
554
1.46
1.66
5.1
4.9
21.52
21.95
%
0.09
45
301
86
697
1.44
1.64
6.6
6.0
2.29
2.64
ug/l
0.30
74
623
13
63
2.14
1.64
1.5
1.6
—
—
—
0
0
17
92
1.93
1.62
1.5
1.4
—
—
—
0
0
155
1415
1.62
1.56
5.9
5.5
4.53
4.41
mmol/l
0.63
143
1303
28
180
1.66
1.54
3.3
3.9
5.88
5.70
kpa
0.44
28
172
150
1362
1.56
1.51
5.0
4.6
1.38
1.27
mmol/l
1.25
134
1238
62
479
1.45
1.51
5.5
3.9
0.00
0.00
estimate
-0.00
23
164
27
175
1.64
1.45
3.9
3.8
—
—
—
0
0
13
67
2.01
1.42
1.6
1.7
—
—
—
0
0
5
17
2.99
1.37
1.0
1.0
—
—
—
0
0
12
61
2.04
1.36
1.5
1.2
—
—
—
0
0
153
1406
1.54
1.34
5.9
5.4
1.41
1.43
mmol/l
0.29
140
1284
68
545
1.39
1.32
2.0
1.7
20.56
20.12
nmol/l
0.07
59
450
54
417
1.42
1.30
4.3
3.4
0.74
0.79
ug/l
0.25
44
293
5
18
2.83
1.29
7.4
2.9
5.78
12.16
nmol/l
—
5
18
17
100
1.77
1.28
2.6
3.2
1.75
1.82
mmol/l
0.04
12
74
8
35
2.34
1.28
1.9
1.3
—
—
—
0
0
34
240
1.51
1.28
1.5
1.3
22.92
15.77
u/ml
0.14
13
90
8
37
2.21
1.23
2.8
1.4
—
—
—
0
0
48
368
1.41
1.20
1.9
1.9
394.85
453.66
pmol/l
1.14
40
306
90
766
1.34
1.17
2.5
2.2
100.65
96.51
pmol/l
0.27
49
390
19
120
1.65
1.14
1.8
1.6
—
—
—
0
0
29
207
1.48
1.05
5.0
5.3
29.95
33.25
%
0.96
21
132
75
632
1.32
1.01
5.8
4.1
0.00
0.02
estimate
0.50
17
160
129
1174
1.33
0.99
34.7
22.6
14.01
13.86
%
0.65
129
1163
151
1409
1.41
0.97
8.2
7.2
40.19
40.63
mmol/mol
0.28
144
1316
83
723
1.27
0.84
3.0
2.5
—
—
—
0
0
43
344
1.33
0.82
1.8
1.7
1163.31
1165.18
nmol/l
0.00
34
266
72
619
1.27
0.81
5.2
4.1
5.09
10.24
mg/mmol
1.38
47
398
41
327
1.33
0.80
1.6
1.2
2.61
1.43
u/ml
—
9
94
8
48
1.70
0.80
1.1
1.3
—
—
—
0
0
45
366
1.30
0.77
5.6
4.1
1.02
1.02
kg/l
0.12
31
247
15
100
1.54
0.75
4.5
3.9
46.02
46.56
%
0.02
15
95
29
223
1.36
0.72
2.5
1.9
—
—
—
0
0
15
102
1.51
0.70
5.4
3.8
1.01
1.02
ratio
1.90
15
95
5
27
1.87
0.69
2.8
3.2
1.22
1.20
mmol/l
—
5
27
5
27
1.87
0.69
2.8
3.2
104.40
106.22
mmol/l
—
5
27
12
78
1.58
0.67
2.7
3.6
1.26
1.58
%
0.98
12
72
54
458
1.25
0.67
5.1
3.7
0.00
0.01
estimate
0.50
16
152
12
79
1.56
0.64
2.0
1.7
0.19
4.49
ug/l
0.67
12
71
8
49
1.66
0.63
1.1
1.2
—
—
—
0
0
10
65
1.57
0.56
1.5
1.2
146.16
127.51
u/ml
—
5
20
9
59
1.55
0.56
2.7
3.0
—
—
—
0
0
9
60
1.53
0.55
1.0
1.0
—
—
—
0
0
14
101
1.42
0.51
2.6
2.7
0.54
0.61
%
0.37
14
101
16
119
1.38
0.50
6.0
7.9
25.41
24.62
mmol/l
0.37
16
119
14
102
1.40
0.49
2.7
2.7
1.55
1.10
%
0.34
14
102
26
213
1.26
0.44
4.2
7.5
5.06
5.05
kpa
0.02
26
208
26
213
1.26
0.44
4.2
7.5
11.63
11.67
kpa
0.01
26
208
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
0
17
0.00
0.41
0.0
1.0
—
—
—
0
0
11
148
0.73
0.40
1.4
1.3
—
—
—
0
0
0
19
0.00
0.39
0.0
1.0
—
526.64
—
0
11
0
19
0.00
0.39
0.0
1.1
—
41.93
—
0
9
15
118
1.30
0.34
5.3
9.8
24.41
24.48
mmol/l
0.03
15
118
6
46
1.31
0.33
1.8
1.3
—
—
—
0
0
25
286
0.85
0.26
2.0
1.9
29.02
29.36
s
0.14
25
278
5
38
1.32
0.23
1.4
1.5
—
—
—
0
0
8
103
0.77
0.21
3.4
6.3
26.22
24.08
mmol/l
—
8
98
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
8.83
—
0
11
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
6
49
1.23
0.20
1.2
1.3
—
2.39
—
0
9
6
49
1.23
0.20
1.2
1.7
—
—
—
0
0
12
102
1.19
0.15
2.0
2.5
—
24.99
—
0
8
63
602
1.07
0.13
1.8
2.0
1.51
1.31
mmol/l
0.50
54
488
38
358
1.08
0.11
3.5
3.8
380.93
356.40
ng/l
0.03
30
295
20
183
1.10
0.10
8.2
8.0
—
—
—
0
0
5
44
1.14
0.10
1.6
1.5
—
—
—
0
0
6
54
1.11
0.09
1.2
1.4
—
—
—
0
0
5
62
0.80
0.08
1.4
1.4
—
—
—
0
0
17
181
0.93
0.05
1.2
1.4
—
—
—
0
0
12
127
0.94
0.01
6.4
9.9
95.90
93.90
%
2.01
12
127
14
139
1.01
0.00
1.3
1.3
—
—
—
0
0
7
69
1.02
0.00
1.4
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
14.20
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.6
—
4.80
—
0
5
0
5
0.00
-0.00
0.0
3.6
—
9.58
—
0
5
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
17.58
—
0
6
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
50.25
—
0
6
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_PAGET and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_PAGET | 1.012 [0.76, 1.35] | 0.938 |
| Birth year | 0.999 [0.99, 1.01] | 0.783 |
During the follow-up period (1.1.1998 — 31.12.2019), 86 out of 317 females with M13_PAGET died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_PAGET | 1.119 [0.88, 1.43] | 0.362 |
| Birth year | 0.99 [0.98, 1.0] | 0.027 |
During the follow-up period (1.1.1998 — 31.12.2019), 132 out of 382 males with M13_PAGET died.
Mortality risk
Mortality risk for people of age
years, who have M13_PAGET.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.097% | 0.261% |
| 5 | 0.632% | 1.405% |
| 10 | 1.7% | 3.576% |
| 15 | 3.327% | 6.476% |
| 20 | 6.058% | 11.352% |
Relationships between endpoints
↥Index endpoint: M13_PAGET – Paget disease
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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