Mucocutaneous lymph node syndrome [Kawasaki]

M13_KAWASAKI

mucocutaneous lymph node syndrome: Kawasaki disease (KD) is a febrile, systemic, self-limiting vasculitis affecting children and characterized by inflammation in the medium sized vessels associated with coronary arterial aneurysms (CAA) that may be life threatening when untreated. KD is the most common cause of acquired heart disease in children in developed countries and is a risk factor for ischemic heart disease in adulthood.

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Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M30.3 Hospital discharge: ICD-9 — 4461 Cause of death: ICD-10 — M30.3 Cause of death: ICD-9 — 4461 2 out of 7 registries used, show all original rules.	88
4. Check minimum number of events None	88
5. Include endpoints None	88
6. Filter based on genotype QC (FinnGen only)	80

Control definitions (FinnGen only)

Control exclude: M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: M30
Name in latin: Syndroma mucocutaneum lymphonodorum (Kawasaki)

NAME	M13_KAWASAKI
CONTROL_EXCLUDE	M13_SYSTCONNECT
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M303
HD_ICD_9	4461
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M303
COD_ICD_9	4461
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Mucocutaneous lymph node syndrome [Kawasaki] based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1816	687	1129
Only index persons	1386	500	886
Unadjusted period prevalence (%)
Whole population	0.03	0.02	0.03
Only index persons	0.03	0.02	0.03
Median age at first event (years)
Whole population	-	4.24	3.84
Only index persons	4.78	5.46	4.39

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	80	43	37
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	8.00	6.89	9.29

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
83: Matched controls
830

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M30.3

ICD-10 Finland

Mucocutaneous lymph node syndrome [Kawasaki]

+∞

71.5

4461A

ICD-9 Finland

Polyarteritis nodosa and allied conditions, Acute febrile mucocutaneous lymph node syndrome [MCLS]

+∞

32.4

M30.0

ICD-10 Finland

Polyarteritis nodosa

+∞

11.7

FM1EE

NOMESCO Finland

Extensive structural and functional ultrasound examination of heart

4.1

7.4

L04AX01

ATC

azathioprine; systemic

9.8

6.3

H02AB06

ATC

prednisolone; systemic

3.1

6.1

190

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3023368) Bacteria identified in Blood by Culture

136

2.60

3.80

3.4

4.2

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

4.07

2.76

1.0

1.5

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.73

2.72

1.9

1.7

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

3.36

2.68

1.5

1.7

—

(3002582) Erythrocytes [#/volume] in Urine

226

2.05

2.53

2.8

3.6

10.53

324.05

e6/l

0.57

175

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

2.93

2.15

2.8

2.1

—

(3004588) Protein electrophoresis panel - Serum or Plasma

3.72

2.10

1.1

3.1

—

(36304419) Bacteria [Presence] in Urine

197

1.92

2.03

3.0

3.6

—

estimate

—

(3030467) Casts [#/volume] in Urine by Automated count

198

1.90

1.99

2.9

3.7

0.36

0.38

e6/l

0.02

145

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

4.76

1.97

1.0

1.3

—

(3035933) Granulocytes/Leukocytes in Blood

3.38

1.92

2.6

3.2

54.29

52.30

—

(3041096) Erythrocytes [Presence] in Urine by Automated

184

1.89

2.9

2.7

0.00

estimate

-0.00

(44790048) Parainfluenza type 2 nucleic acid detection

3.72

1.87

2.7

1.4

—

(44790049) Parainfluenza type 3 nucleic acid detection

3.72

1.87

2.7

1.4

—

(44806118) Parainfluenza type 4 nucleic acid detection

3.72

1.87

2.7

1.4

—

(44790047) Parainfluenza type 1 nucleic acid detection

3.72

1.87

2.7

1.4

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

231

1.80

1.77

3.4

4.1

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

224

1.79

1.71

9.1

7.0

34.65

37.34

g/l

1.19

217

(3018095) Leukocytes [#/volume] in Urine

270

1.75

1.68

3.1

4.3

38.15

32.61

e6/l

0.10

183

(3029937) Albumin [Presence] in Urine by Test strip

182

1.81

1.67

2.9

3.5

0.00

estimate

-0.00

(3035715) Granulocytes [#/volume] in Blood

3.73

1.64

3.2

4.4

3.54

3.35

e9/l

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

245

1.74

1.62

3.1

3.3

0.00

0.02

estimate

0.49

(3017181) Myelocytes/Leukocytes in Blood

2.33

1.58

2.5

3.8

0.20

0.95

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

2.57

1.58

1.4

1.6

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

2.73

1.55

1.6

1.5

—

(3018418) pH of Serum or Plasma

145

1.81

1.50

4.7

4.5

7.39

0.08

107

(3044889) 12 lead EKG panel

373

1.68

1.48

3.3

3.0

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

1.98

1.35

6.4

6.8

25.00

23.50

mmol/l

1.87

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

2.89

1.30

2.8

1.8

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

2.41

1.21

2.7

1.5

—

(3018010) Neutrophils/Leukocytes in Blood

367

1.57

1.18

7.8

6.8

58.54

55.03

1.19

354

(3021601) Nitrite [Presence] in Urine by Test strip

348

1.56

1.17

3.3

3.5

0.00

estimate

-0.00

(3000991) Gas panel - Venous blood

1.81

1.13

5.7

14.7

—

(3032080) INR in Blood by Coagulation assay

210

1.59

1.12

8.4

8.8

1.01

1.16

inr

2.73

174

(3035350) Ketones [Presence] in Urine by Test strip

351

1.54

1.11

3.3

3.5

0.00

estimate

-0.00

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.83

1.10

8.3

14.0

25.79

24.91

mmol/l

0.83

(3037467) Urinalysis macro (dipstick) panel - Urine

472

1.57

1.09

5.5

4.4

—

(42870588) Differential panel, method unspecified - Blood

266

1.55

1.09

8.9

7.2

—

(3022145) Colonoscopy Study observation

2.12

1.09

1.6

1.7

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

124

1.69

1.09

2.1

3.4

0.21

0.31

e6/l

—

(3002030) Lymphocytes/Leukocytes in Blood

373

1.52

1.06

8.3

7.0

26.73

31.01

1.93

361

(3000492) Spirometry study

1.89

1.00

1.2

1.4

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

2.23

0.93

1.3

1.1

0.78

0.80

g/l

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

2.23

0.93

1.3

1.1

1.45

1.46

g/l

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.23

0.93

2.7

1.4

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

176

0.57

0.93

3.9

2.4

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

165

1.54

0.91

2.9

56.22

56.03

u/l

0.01

155

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.08

0.89

1.7

1.5

—

(3001019) Free T4 and TSH panel - Serum or Plasma

2.08

0.89

1.2

1.4

—

(3021589) Normoblasts [#/volume] in Blood

363

1.45

0.88

11.0

8.3

0.00

e9/l

0.50

289

(40760892) CBC W Ordered Manual Differential panel - Blood

140

1.56

0.87

5.4

—

(3009261) Glucose [Presence] in Urine by Test strip

354

1.45

0.86

3.4

3.6

0.00

estimate

-0.00

(3037121) Protein [Mass/volume] in Urine

1.94

0.83

5.5

6.1

395.00

215.23

mg/l

—

(3006504) Eosinophils/Leukocytes in Blood

356

1.43

0.83

8.9

7.1

2.45

2.92

1.03

337

(3022313) Gas panel - Capillary blood

1.67

0.80

7.1

5.4

—

(1761868) Lipid panel - Serum or Plasma

212

0.64

0.77

2.1

2.3

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.77

0.72

3.6

2.3

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.73

0.70

1.1

1.0

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.73

0.70

1.4

1.5

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

132

1.46

0.64

1.7

2.8

1.61

1.82

mg/l

0.08

102

(3019069) Monocytes/Leukocytes in Blood

358

1.35

0.63

9.2

7.3

8.20

8.27

0.07

341

(3027944) Amphetamines [Presence] in Urine

106

1.51

0.63

1.2

1.8

—

(3027008) Opiates [Presence] in Urine

106

1.51

0.63

1.2

1.8

—

(3028300) Cannabinoids [Presence] in Urine

106

1.51

0.63

1.2

1.8

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

160

1.42

0.61

6.5

2.9

56.60

22.16

ng/l

—

(3002385) Erythrocyte [DistWidth] in Red Blood Cells

649

1.50

0.61

21.1

15.7

13.35

13.24

0.30

639

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

707

1.63

0.60

11.5

9.5

36.36

27.25

u/l

0.75

687

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

1.53

0.60

8.3

5.5

1.95

1.14

mmol/l

1.03

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

533

1.37

0.59

3.5

4.1

14.69

14.56

pmol/l

0.15

485

(3020564) Creatinine [Moles/volume] in Serum or Plasma

698

1.55

0.57

18.6

13.5

69.15

68.99

umol/l

0.01

684

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

133

0.64

0.57

1.4

1.5

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

237

1.34

0.56

1.9

1.8

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.52

0.55

3.3

1.6

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

118

1.44

0.55

3.6

3.8

53.10

366.13

ng/l

—

(3015736) pH of Urine

287

1.31

0.53

3.0

3.2

6.25

6.41

0.32

139

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.50

0.53

2.9

1.5

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.50

0.53

1.8

1.6

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

120

1.41

0.51

2.3

3.4

0.43

1.41

e6/l

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

320

0.77

0.47

4.1

3.0

—

estimate

—

(3000764) Benzodiazepines [Presence] in Urine

104

1.42

0.47

1.2

1.8

—

(40761536) Microorganisms panel - Urine sediment

1.42

0.43

3.1

3.5

—

(3044640) Blood type and Crossmatch panel - Blood

223

0.75

0.43

3.7

2.4

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

106

1.39

0.42

2.4

2.2

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

208

1.29

0.42

1.8

1.9

99.59

95.33

pmol/l

0.13

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.41

0.0

1.1

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.41

0.0

1.1

—

(3042936) Bacteria identified in Isolate by Culture

1.46

0.41

4.3

2.6

—

(4024509) Urine culture

1.50

0.41

2.6

1.6

—

(3020682) Albumin/Creatinine [Ratio] in Urine

125

1.35

0.41

5.2

4.1

83.76

20.16

mg/mmol

—

(40768797) Stomach Pathology biopsy report

1.43

0.40

1.7

1.3

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

296

1.25

0.40

5.2

6.9

20.21

11.35

umol/l

0.44

280

(3003458) Phosphate [Moles/volume] in Serum or Plasma

124

0.69

0.38

9.9

10.8

1.13

1.19

mmol/l

—

116

(3003694) ABO and Rh group [Type] in Blood

272

0.79

0.38

1.5

1.7

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

1.46

0.36

1.3

5.2

99.33

90.55

—

(3016879) Cocaine [Presence] in Urine

101

1.34

0.34

1.2

1.8

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

176

1.26

0.33

2.3

1.7

—

(3013512) EKG study

130

1.29

0.31

4.8

3.1

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

225

0.80

0.31

3.1

2.8

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

627

1.26

0.30

3.9

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

212

0.81

0.28

2.7

2.6

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

692

1.31

0.28

18.9

12.2

26.89

22.12

mg/l

0.47

545

(1001926) Buprenorphine [Presence] in Urine by Screen method

1.32

0.28

1.2

1.9

—

(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma

0.66

0.27

1.4

2.7

—

6153.55

—

(3012516) Albumin [Mass/volume] in Urine

124

1.26

0.26

5.1

3.7

263.98

133.54

mg/l

—

(3026008) Bacteria identified in Urine by Culture

199

0.82

0.25

3.6

2.3

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

1.30

0.23

1.0

1.2

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.21

0.0

1.2

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.3

—

(4195642) Thrombophilia screening test

0.00

0.21

0.0

1.3

—

(4034850) Laboratory test

0.00

0.21

0.0

19.8

—

(3018133) Calcium [Moles/volume] in Urine

0.00

0.21

0.0

4.0

—

2.50

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

25.7

—

1655.00

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

16.4

—

911.30

—

(3034603) RHD gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.21

0.0

1.3

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

8.5

—

6.47

—

(3011897) Casein IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

0.39

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.6

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.6

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.21

0.0

1.5

—

1.18

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.6

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.27

0.21

1.0

1.4

—

(3009466) Valproate [Moles/volume] in Serum or Plasma

0.00

0.20

0.0

4.6

—

362.43

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.20

0.0

1.1

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.20

0.0

2.4

—

8.61

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

109

1.23

0.20

3.5

1.7

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

1.19

0.20

1.0

1.6

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

1.17

0.19

1.0

1.7

—

(3007164) IgA [Mass/volume] in Serum or Plasma

225

0.85

0.19

1.6

1.7

2.07

1.91

g/l

0.15

125

(3002256) Pathology report gross observation

1.14

0.17

1.1

1.2

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

1.19

0.16

2.0

1.6

345.11

451.44

pmol/l

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

132

1.17

0.14

2.4

2.3

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

270

0.89

0.13

2.3

1.8

—

(36660697) Celiac disease serology panel - Serum

1.17

0.11

1.3

1.2

—

(40768804) Tissue Pathology biopsy report

213

1.11

0.11

2.4

1.9

—

(3028707) Methadone [Presence] in Urine by Screen method

1.17

0.10

1.4

2.3

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

175

1.11

0.09

2.8

3.4

2.37

2.38

mmol/l

0.15

159

(3050129) First trimester maternal screen panel - Serum or Plasma

0.81

0.08

1.5

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.80

0.08

1.0

1.1

—

(3019832) Treponema pallidum Ab [Presence] in Serum

214

0.91

0.08

1.6

1.9

—

(3011288) Drugs identified in Urine by Screen method Nominal

1.07

0.08

1.5

2.0

—

(40761511) CBC panel - Blood by Automated count

708

1.13

0.07

16.9

10.2

—

(21494755) Public health laboratory ask at order entry panel

1.04

0.07

1.2

1.3

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.04

0.07

4.7

1.6

—

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

530

1.05

0.04

14.6

10.2

95.40

97.14

ml/min/173m2

0.18

457

(46235355) HIV 1 and 2 tests - Meaningful Use set

289

0.95

0.03

2.7

2.4

—

(40758558) Short blood count panel - Blood

238

1.01

0.00

6.0

6.5

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

137

1.03

0.00

2.3

1.6

—

(3043409) Potassium [Moles/volume] in Arterial blood

0.00

0.0

3.0

—

3.92

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

54.13

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.0

1.8

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

1.8

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.0

1.6

—

7.66

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.4

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

1.8

—

(3026048) Bordetella pertussis IgG Ab [Units/volume] in Serum

0.00

0.0

1.1

—

25.51

—

(3003129) Base excess in Capillary blood by calculation

0.00

0.0

1.5

—

-0.81

—

(3019897) Erythrocyte [DistWidth] in Red Blood Cells by Automated count

0.00

0.0

1.3

—

13.80

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

2.0

—

(3010503) CD19 cells [#/volume] in Blood

0.00

-0.00

0.0

2.7

—

137.29

—

(44817194) Complement alternate pathway AH50 actual/normal in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

86.80

—

(3022229) Phosphate [Moles/volume] in Urine

0.00

-0.00

0.0

4.3

—

12.65

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.87

-0.00

1.3

1.7

62.18

55.10

ug/l

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

4.3

—

2.15

—

(3013336) Amino acids [Identifier] in Serum or Plasma

0.00

-0.00

0.0

4.7

—

(3011841) English Walnut IgE Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

2.15

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(3003191) Choriogonadotropin [Presence] in Serum or Plasma

1.02

-0.00

2.0

1.6

—

(3029396) Erythrocyte agglutination [Presence] in Blood

0.00

-0.00

0.0

3.0

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.89

-0.00

2.0

2.3

—

(3033882) Carnitine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.3

—

28.17

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.2

—

21.08

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.7

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3025378) Microscopic observation [Identifier] in Cervix by Cyto stain

0.00

-0.00

0.0

1.0

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

1.02

-0.00

1.2

1.6

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

-0.00

0.0

1.3

—

1.21

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

-0.00

0.0

1.3

—

109.17

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(44806420) Estimation of glomerular filtration rate

0.00

-0.00

0.0

1.4

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

-0.00

0.0

1.3

—

(40765089) Chromosome analysis panel - Blood by G-banded

0.00

-0.00

0.0

1.0

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.93

-0.00

1.7

1.6

—

(3044941) Cell count panel - Synovial fluid

0.00

-0.00

0.0

1.2

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

-0.00

0.0

1.3

—

4.10

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(3000722) Carnitine free (C0) [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.3

—

21.83

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

-0.00

0.0

1.2

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.92

-0.00

2.0

1.7

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

-0.00

0.0

1.2

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

-0.00

0.0

1.4

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

0.00

-0.00

0.0

1.6

—

(3028334) Neisseria gonorrhoeae [Presence] in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

-0.00

0.0

1.0

—

1.64

—

(3005011) Chlamydia sp Ab [Titer] in Serum

0.00

-0.00

0.0

1.4

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.7

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

-0.00

0.0

1.4

—

11.29

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(40768793) Breast Pathology biopsy report

0.00

-0.00

0.0

1.3

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

-0.00

0.0

1.3

—

(3000494) Fungus identified in Specimen by Culture

1.01

-0.00

2.8

1.9

—

(3051651) Icteric interference index of Serum or Plasma

0.00

-0.00

0.0

1.1

—

1.14

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3015183) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells

0.00

-0.00

0.0

1.0

—

14.40

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

3.8

—

121.60

—

(40761872) Peanut recombinant (rAra h) 2 IgE Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.3

—

1.14

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

-0.00

0.0

9.6

—

629.60

—

(3023351) European house dust mite IgE Ab [Units/volume] in Serum

0.94

-0.00

1.0

1.1

2.37

1.93

u/ml

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

4.0

—

49.80

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

0.97

-0.00

8.0

14.2

102.71

105.11

mmol/l

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.8

—

1.94

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.9

—

9.00

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

-0.00

0.0

1.0

—

(4062490) Immunoglobulin typing, IgG

0.00

-0.00

0.0

1.0

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.5

—

(44816893) Food Allergen Mix 50 (Kiwi+Pineapple+Banana+Mango) IgE Ab [Units/volume] in Serum by Multidisk

0.00

-0.00

0.0

1.0

—

0.27

—

Mortality – FinRegistry

↥

Association

Association between endpoint M13_KAWASAKI and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have M13_KAWASAKI.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: M13_KAWASAKI – Mucocutaneous lymph node syndrome [Kawasaki]

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Mucocutaneous lymph node syndrome [Kawasaki]

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints