synovitis: ['Inflammation of the SYNOVIAL MEMBRANE [ MeSH ]']
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
184 |
4. Check minimum number of eventsNone |
184 |
5. Include endpointsNone |
184 |
6. Filter based on genotype QC (FinnGen only) |
155 |
Control definitions (FinnGen only)
- Control exclude
- M13_SOFTTISSUE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M65
- Name in latin
- [Teno]synovitis infectiosa
Similar endpoints
↥List of similar endpoints to
Other infective (teno)synovitis
based on the number of shared cases.
Similar with more cases:
- Disorders of synovium and tendon
- Soft tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any operation in hilmo
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1009 | 530 | 477 |
| Only index persons | 967 | 512 | 455 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 50.52 | 51.73 | 49.28 |
| Only index persons | 50.64 | 51.52 | 49.64 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 155 | 93 | 62 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 54.56 | 52.80 | 57.19 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 166
- Matched controls
- 1660
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M65.1
ICD-10 Finland
Other infective (teno)synovitis
+∞
234.0
164
*
NDM40
NOMESCO Finland
Discission of sheath of tendon of wrist or hand
278.5
24.3
24
*
G56.0
ICD-10 Finland
Carpal tunnel syndrome
6.6
23.8
46
91
ACC51
NOMESCO Finland
Release of median nerve
7.9
17.5
26
38
M13.9
ICD-10 Finland
Arthritis, unspecified
7.3
16.9
27
43
M79.6
ICD-10 Finland
Pain in limb
3.9
16.6
93
412
NDS00
NOMESCO Finland
Incision and debridement of infection of tendon of wrist or hand
+∞
15.9
15
*
L03.0
ICD-10 Finland
Cellulitis of finger and toe
6.0
15.8
31
61
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
7.2
15.0
24
38
M25.5
ICD-10 Finland
Pain in joint
3.6
14.9
76
312
M19.0
ICD-10 Finland
Primary arthrosis of other joints
6.0
14.5
28
54
N03AX16
ATC
[U] pregabalin
4.0
14.5
55
185
M65.9
ICD-10 Finland
Synovitis and tenosynovitis, unspecified
19.8
14.3
21
12
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
5.9
13.7
27
53
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
4.9
12.3
30
71
X59
ICD-10 Finland
Exposure to unspecified factor
3.7
11.9
47
160
M65.3
ICD-10 Finland
Trigger finger
16.6
11.6
18
12
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
6.4
11.3
20
35
N02AX02
ATC
tramadol; systemic, rectal
3.0
10.9
82
408
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
30.3
10.9
14
5
ZXA00
NOMESCO Finland
Right side
3.2
10.7
58
240
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.9
10.3
98
550
M65.8
ICD-10 Finland
Other synovitis and tenosynovitis
15.9
10.2
16
11
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
5.3
9.8
21
44
R4120
NOMESCO Finland
Occupational therapy
5.3
9.8
21
44
NHL50
NOMESCO Finland
Tenolysis or tenosynovectomy of foot
+∞
9.5
9
*
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
10.4
9.0
17
18
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.7
8.8
84
461
M75.1
ICD-10 Finland
Rotator cuff syndrome
3.2
8.8
41
153
J01FF01
ATC
clindamycin; systemic
2.9
8.7
55
245
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
13.8
8.5
14
11
H02AB06
ATC
prednisolone; systemic
2.6
8.5
90
517
M65.0
ICD-10 Finland
Abscess of tendon sheath
+∞
8.4
8
*
M01AE03
ATC
ketoprofen; systemic, rectal
2.6
8.4
74
389
NBL00
NOMESCO Finland
Suture or reinsertation of rotator cuff of shoulder
12.6
8.2
14
12
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
10.9
8.2
15
15
A02BC02
ATC
pantoprazole; systemic
2.9
8.1
125
855
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
3.5
8.1
31
102
R52.9
ICD-10 Finland
Pain, unspecified
3.8
7.8
26
78
A46
ICD-10 Finland
Erysipelas
3.3
7.6
33
117
M54.5
ICD-10 Finland
Low back pain
2.6
7.6
65
333
L12
ICPC
Hand/finger symptom/complaint
3.0
7.6
40
160
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.7
7.5
53
248
L04AX03
ATC
methotrexate; systemic
3.7
7.5
25
75
NDL52
NOMESCO Finland
Tenosynovectomy of hand
31.5
7.2
9
*
Z3226
NOMESCO Finland
Physiotherapist
3.0
7.2
36
139
Z01.8
ICD-10 Finland
Other specified special examinations
2.8
7.1
44
192
P01BA02
ATC
hydroxychloroquine; oral
4.1
6.9
20
54
W22
ICD-10 Finland
Striking against or struck by other object(s)
4.4
6.5
17
42
M01AH05
ATC
etoricoxib; oral
2.4
6.5
111
759
M79.0
ICD-10 Finland
Rheumatism, unspecified
72.5
6.5
7
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.3
6.3
65
358
QCB05
NOMESCO Finland
Revision of wound of skin of upper limb
27.8
6.3
8
*
NBG10
NOMESCO Finland
Acromioplastia
27.8
6.3
8
*
S46.0
ICD-10 Finland
Injury of muscle(s) and tendon(s) of the rotator cuff of shoulder
4.4
6.2
16
39
J45.9
ICD-10 Finland
Asthma, unspecified
2.7
6.2
38
163
R4110, ,
SPAT
3.0
6.2
30
113
M48.0
ICD-10 Finland
Spinal stenosis
3.4
6.0
23
75
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
59
223
3.55
12.88
1.5
1.2
17.30
13.02
u/ml
0.16
24
93
59
244
3.20
10.90
1.4
1.2
25.60
36.59
iu/ml
0.54
21
82
66
337
2.59
7.83
2.8
2.9
356.33
338.00
umol/l
0.64
57
295
120
812
2.72
7.83
10.1
10.1
4.37
3.98
e9/l
0.85
102
722
140
1031
3.29
7.69
6.8
3.7
12.93
11.03
mm/h
0.90
135
951
143
1087
3.28
7.00
10.6
7.7
80.53
78.48
u/l
0.20
137
1022
17
32
5.79
6.36
3.2
3.0
—
—
—
0
0
94
607
2.26
6.20
6.4
6.1
1.22
1.21
mmol/l
0.46
88
553
101
679
2.24
5.95
8.0
6.9
1.21
1.21
mmol/l
0.03
92
583
111
811
2.11
4.85
5.0
4.5
6.72
6.74
mmol/l
0.04
105
769
104
742
2.08
4.85
6.8
6.5
11.82
11.56
umol/l
0.08
99
714
70
436
2.05
4.72
2.4
2.3
55.85
81.91
u/l
1.07
65
403
159
1407
4.08
4.68
25.1
13.1
25.49
23.96
mg/l
0.26
142
1120
52
297
2.09
4.37
1.6
1.6
0.68
1.34
mg/l
1.96
39
231
86
594
1.93
4.18
2.3
1.9
90.81
98.08
pmol/l
0.76
44
304
12
26
4.89
4.15
1.6
1.4
—
—
—
0
0
12
26
4.89
4.15
2.3
1.6
—
—
—
0
0
100
735
1.91
3.94
6.0
3.3
0.00
0.00
estimate
-0.00
24
136
98
720
1.88
3.82
5.8
3.2
0.00
0.00
estimate
-0.00
24
146
11
24
4.83
3.82
1.7
1.4
—
—
—
0
0
54
328
1.96
3.76
2.9
1.9
3.44
3.12
mg/l
0.35
49
277
99
733
1.87
3.73
5.8
3.2
0.00
0.00
estimate
-0.00
24
145
9
17
5.53
3.56
1.3
1.6
—
—
—
0
0
10
22
4.77
3.49
1.4
1.1
10.80
1.22
u/ml
—
5
9
89
655
1.77
3.26
3.5
2.6
193.31
113.16
ug/l
0.47
83
604
8
15
5.54
3.23
1.0
1.5
—
—
—
0
0
13
44
3.12
3.21
2.8
1.9
23.98
25.46
mmol/l
0.53
13
44
113
901
1.80
3.06
6.1
3.8
—
5851.54
—
0
13
86
635
1.74
3.05
4.0
2.7
—
—
estimate
—
0
0
10
26
4.02
3.03
1.6
1.4
—
—
—
0
0
6
9
6.86
2.89
1.2
1.0
—
—
—
0
0
132
1116
1.89
2.80
4.2
4.0
14.84
14.70
pmol/l
0.28
121
1024
55
367
1.75
2.74
3.5
3.4
1875.45
1072.49
ng/l
0.57
46
312
6
10
6.18
2.72
1.0
1.0
—
—
—
0
0
6
10
6.18
2.72
1.0
1.0
—
—
—
0
0
80
593
1.67
2.70
2.1
1.9
1.41
1.35
mmol/l
0.29
71
507
14
56
2.64
2.61
1.7
2.2
0.62
1.79
ug/l
0.71
14
47
17
77
2.35
2.47
1.6
1.3
169.12
423.07
u/ml
0.36
17
68
6
12
5.14
2.42
1.0
1.0
—
—
—
0
0
5
8
6.40
2.39
1.0
1.0
—
—
—
0
0
16
72
2.35
2.36
4.4
6.9
23.96
25.15
mmol/l
0.65
16
72
9
28
3.34
2.34
1.4
1.6
—
—
—
0
0
8
23
3.60
2.30
1.4
1.3
417.38
37.59
e6/l
—
8
17
8
23
3.60
2.30
1.1
3.0
13.60
5.94
pmol/l
—
8
23
8
23
3.60
2.30
1.0
1.1
—
—
—
0
0
21
108
2.08
2.27
5.2
2.1
0.06
0.28
e6/l
1.82
21
102
54
377
1.64
2.22
1.7
1.5
18.45
20.72
nmol/l
0.54
45
317
32
194
1.80
2.17
1.7
1.6
1099.96
1174.81
nmol/l
0.19
27
141
26
148
1.90
2.14
2.4
2.5
—
—
—
0
0
150
1358
2.08
2.11
7.2
5.8
39.68
38.89
mmol/mol
0.52
141
1278
9
32
2.91
2.03
1.4
1.6
—
—
—
0
0
161
1521
2.94
2.00
28.5
17.5
79.21
74.13
umol/l
1.03
161
1499
7
21
3.43
1.99
1.0
1.1
—
—
—
0
0
54
387
1.59
1.97
6.6
3.3
0.00
0.01
estimate
0.50
23
139
57
414
1.57
1.96
4.7
2.7
0.06
0.00
estimate
0.48
17
114
8
27
3.06
1.96
1.5
1.6
—
—
—
0
0
63
471
1.54
1.90
4.6
2.8
—
—
—
0
0
146
1323
1.86
1.85
5.8
5.0
1.89
1.93
mu/l
0.16
139
1217
5
12
4.26
1.83
1.2
1.0
—
—
—
0
0
68
524
1.50
1.76
5.0
3.3
59.83
28.47
ng/l
0.55
54
356
6
18
3.42
1.76
1.8
1.9
-0.55
1.71
mmol/l
—
6
18
39
265
1.62
1.75
1.5
1.6
—
—
—
0
0
5
13
3.93
1.72
1.6
2.9
—
—
—
0
0
25
152
1.76
1.68
6.3
8.0
5.12
5.22
kpa
0.22
25
146
25
152
1.76
1.68
6.3
7.9
13.17
12.56
kpa
0.21
25
147
21
122
1.83
1.64
5.4
3.0
—
—
—
0
0
5
14
3.65
1.62
1.0
1.0
—
—
—
0
0
5
14
3.65
1.62
1.6
2.8
—
—
—
0
0
60
460
1.48
1.56
4.2
4.0
9.16
6.76
mg/mmol
0.25
42
283
37
256
1.57
1.54
5.5
3.6
1180.28
238.49
ng/l
0.49
25
204
154
1436
2.00
1.53
5.4
4.8
1.43
1.49
mmol/l
1.44
148
1330
15
80
1.96
1.50
6.7
9.1
0.59
0.69
%
0.43
15
80
31
207
1.61
1.49
5.1
2.5
3.61
2.61
e6/l
0.30
18
94
150
1390
1.82
1.48
5.4
4.8
6.00
5.91
mmol/l
0.24
142
1292
43
311
1.52
1.47
1.4
1.2
2.24
1.58
u/ml
0.16
13
76
156
1464
2.09
1.47
6.3
5.5
2.73
2.78
mmol/l
0.27
150
1360
114
996
1.46
1.45
4.4
3.1
44.55
48.43
u/l
0.27
106
942
44
322
1.50
1.43
6.2
2.9
1.02
1.02
kg/l
0.01
35
205
9
40
2.32
1.42
1.4
1.1
—
—
—
0
0
70
561
1.43
1.42
5.8
3.1
0.05
0.00
estimate
0.48
19
121
15
82
1.91
1.41
6.7
9.1
94.66
93.09
%
0.64
15
82
22
137
1.70
1.38
2.5
2.4
—
—
—
0
0
154
1444
1.92
1.37
5.7
4.9
4.64
4.73
mmol/l
0.49
149
1349
5
17
3.00
1.37
1.0
2.2
18.26
16.69
%
—
5
17
6
25
2.45
1.25
1.5
2.2
—
—
—
0
0
5
19
2.68
1.22
1.6
2.7
110.20
73.09
u/ml
—
5
19
7
30
2.39
1.14
1.3
1.3
—
—
—
0
0
7
32
2.24
1.09
1.4
1.7
—
—
—
0
0
24
163
1.55
1.09
1.9
1.8
—
—
—
0
0
131
1201
1.43
1.07
27.3
16.7
13.91
13.57
%
1.59
131
1189
14
84
1.73
1.01
7.1
8.9
1.86
1.54
%
0.38
14
84
25
175
1.50
1.00
5.7
6.9
105.28
104.66
mmol/l
0.27
25
175
30
220
1.44
0.96
2.2
2.0
—
—
—
0
0
99
878
1.32
0.94
3.0
3.0
—
—
—
0
0
6
27
2.27
0.94
1.2
9.3
—
156.60
—
0
5
146
1378
1.49
0.89
4.7
4.1
1.39
1.30
mmol/l
0.84
136
1274
22
154
1.49
0.89
2.0
1.9
—
—
—
0
0
8
45
1.82
0.85
1.6
1.8
—
—
—
0
0
146
1385
1.45
0.79
20.6
12.9
81.09
83.02
ml/min/173m2
0.51
133
1271
11
67
1.69
0.77
2.4
1.3
—
—
—
0
0
9
54
1.70
0.76
1.2
1.7
—
—
—
0
0
13
84
1.59
0.74
7.7
3.1
110.46
111.07
ng/l
0.01
13
75
12
76
1.62
0.74
6.4
9.0
24.96
24.82
mmol/l
0.06
12
76
7
41
1.74
0.71
1.6
1.6
—
—
—
0
0
42
345
1.29
0.68
3.9
2.3
—
—
—
0
0
7
43
1.65
0.67
1.6
1.5
—
—
—
0
0
11
70
1.61
0.67
1.6
1.9
—
—
—
0
0
14
95
1.52
0.66
1.5
1.6
—
—
—
0
0
6
37
1.64
0.56
1.0
2.3
0.00
0.00
g/l
—
6
32
10
66
1.55
0.54
1.1
1.5
—
—
—
0
0
25
198
1.31
0.53
2.4
1.7
27.99
28.91
s
0.51
25
191
12
84
1.46
0.51
7.6
7.2
23.92
24.35
mmol/l
0.15
12
79
43
377
1.19
0.39
4.6
2.7
0.17
0.56
e6/l
1.85
34
271
0
19
0.00
0.39
0.0
1.2
—
5.08
—
0
10
32
273
1.21
0.39
1.8
1.7
401.28
48148582.21
pmol/l
0.50
25
243
6
41
1.48
0.36
2.7
1.9
32.50
37.24
nmol/l
—
6
41
6
43
1.41
0.35
1.2
4.2
29.47
32.28
mg/l
—
6
38
10
73
1.39
0.35
1.1
1.0
—
—
—
0
0
21
176
1.22
0.30
4.1
4.6
34.15
32.40
%
0.30
13
114
10
77
1.32
0.27
3.1
2.2
24.50
24.83
mmol/l
—
10
77
26
227
1.17
0.26
3.6
2.4
0.96
1.05
e6/l
0.05
14
113
5
37
1.36
0.24
1.2
1.1
—
—
—
0
0
5
37
1.36
0.24
1.2
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
503.86
—
0
7
0
12
0.00
0.21
0.0
1.1
—
32.00
—
0
6
0
13
0.00
0.21
0.0
1.4
—
13.08
—
0
13
0
14
0.00
0.20
0.0
2.1
—
13.17
—
0
14
6
52
1.16
0.19
1.5
1.7
—
—
—
0
0
8
71
1.13
0.16
8.8
9.0
15.02
16.35
%
—
8
66
12
102
1.19
0.15
1.3
1.4
—
—
—
0
0
5
43
1.17
0.10
1.2
4.2
28.62
40.07
mg/l
—
5
38
5
45
1.11
0.10
1.0
1.3
—
—
—
0
0
23
247
0.92
0.09
1.5
1.5
—
—
—
0
0
6
55
1.09
0.09
2.3
1.9
—
—
—
0
0
6
74
0.80
0.07
1.0
1.2
40.85
28.07
iu/l
—
6
67
8
74
1.09
0.07
4.0
2.4
—
—
—
0
0
24
236
1.02
0.00
3.0
2.9
0.74
0.75
ug/l
0.01
17
150
32
316
1.02
0.00
4.2
4.3
24.37
21.62
%
0.44
16
138
15
152
0.99
0.00
15.7
7.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
2.9
—
1359.57
—
0
7
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
9
89
1.01
0.00
3.8
2.4
—
—
—
0
0
9
91
0.99
0.00
1.1
1.9
22.04
62.60
u/ml
—
9
86
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
107.60
—
0
5
11
110
1.00
-0.00
6.2
2.6
57.00
64.07
ml/min/173m2
—
5
41
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.8
—
320.83
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_INFTENOSYNOVITIS and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_INFTENOSYNOVITIS | 1.32 [0.99, 1.76] | 0.057 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 57 out of 406 males with M13_INFTENOSYNOVITIS died.
Mortality risk
Mortality risk for people of age
years, who have M13_INFTENOSYNOVITIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.255% |
| 5 | No data | 1.532% |
| 10 | No data | 3.809% |
| 15 | No data | 7.078% |
| 20 | No data | 11.844% |
Relationships between endpoints
↥Index endpoint: M13_INFTENOSYNOVITIS – Other infective (teno)synovitis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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