No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
212 |
4. Check minimum number of eventsNone |
212 |
5. Include endpointsNone |
212 |
6. Filter based on genotype QC (FinnGen only) |
191 |
Control definitions (FinnGen only)
- Control exclude
- M13_DORSOPATHY
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M48
- Name in latin
- Fractura vertebrae ex fatigatione
Similar endpoints
↥List of similar endpoints to
Fatigue fracture of vertebra
based on the number of shared cases.
Similar with more cases:
- Spondylopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1686 | 892 | 789 |
| Only index persons | 1561 | 823 | 738 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 40.97 | 61.05 | 18.09 |
| Only index persons | 40.52 | 60.94 | 17.75 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 191 | 118 | 73 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.03 |
| Median age at first event (years) | 63.04 | 63.37 | 62.51 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 194
- Matched controls
- 1940
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M48.4
ICD-10 Finland
Fatigue fracture of vertebra
+∞
277.5
193
*
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
88.5
113.3
61
10
M54.5
ICD-10 Finland
Low back pain
12.1
70.7
120
229
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
16.9
51.3
47
36
M54.4
ICD-10 Finland
Lumbago with sciatica
11.1
45.7
57
70
M48.0
ICD-10 Finland
Spinal stenosis
70.2
42.8
48
9
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
7.6
32.9
56
98
N03AX16
ATC
[U] pregabalin
6.5
31.3
66
143
N03AX12
ATC
[U] gabapentin; oral
7.7
30.8
51
86
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
117.6
28.5
30
*
M54.9
ICD-10 Finland
Dorsalgia, unspecified
8.7
28.3
40
56
M05BA04
ATC
alendronic acid; oral
7.0
27.7
50
92
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
34.0
26.4
34
12
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
259.4
23.1
23
*
N02AX02
ATC
tramadol; systemic, rectal
4.1
21.1
98
387
S32.0
ICD-10 Finland
Fracture of lumbar vertebra
24.1
20.7
29
14
M05BX04
ATC
denosumab; parenteral
7.2
19.6
32
52
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
+∞
19.1
18
*
L03
ICPC
Low back symptom/complaint
3.8
16.1
68
244
N02AA05
ATC
oxycodone; systemic
3.9
15.9
59
194
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
3.4
15.7
95
428
N02BF01
ATC
gabapentin; oral
6.4
15.6
28
50
M81.9
ICD-10 Finland
Osteoporosis, unspecified
7.0
15.4
25
40
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
49.3
15.3
18
*
A02BC05
ATC
esomeprazole; systemic
3.2
14.4
92
423
L95
ICPC
Osteoporosis
6.9
14.1
23
37
M80.0
ICD-10 Finland
Postmenopausal osteoporosis with pathological fracture
17.9
13.8
21
13
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
81.0
13.8
15
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.1
13.8
92
432
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
15.3
13.6
22
16
N06AA09
ATC
amitriptyline; systemic
5.8
13.6
27
53
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
17.9
11.9
18
11
M43.0
ICD-10 Finland
Spondylolysis
+∞
11.6
11
*
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
127.2
11.6
12
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
5.0
10.8
25
56
M43.1
ICD-10 Finland
Spondylolisthesis
63.6
10.7
12
*
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
63.6
10.7
12
*
N06AX21
ATC
duloxetine; oral
4.4
10.6
29
75
NA3BG, ,
SPAT
10.5
10.5
20
21
ABC56
NOMESCO Finland
Decompression of lumbar spinal canal and nerve roots
+∞
10.5
10
*
N02AJ06
ATC
codeine and paracetamol; systemic
2.7
10.2
85
435
M25.5
ICD-10 Finland
Pain in joint
2.8
10.1
70
326
M03BX02
ATC
tizanidine; oral
2.6
9.7
108
633
M01AH01
ATC
celecoxib; oral
3.4
9.6
39
133
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.9
9.4
53
220
SPAT1229
SPAT
Assessment of need for aid
4.7
9.1
22
51
P01BA02
ATC
hydroxychloroquine; oral
4.2
9.1
26
69
SPAT1234
SPAT
Support of social functional capacity
5.1
9.0
20
43
M01AH02
ATC
rofecoxib; oral
3.6
9.0
33
105
M54
ICD-10 Finland
Dorsalgia
3.8
8.9
29
85
M84.3
ICD-10 Finland
Stress fracture, not elsewhere classified
15.0
8.8
14
10
X59
ICD-10 Finland
Exposure to unspecified factor
2.9
8.8
49
201
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
4.3
8.7
24
62
L28
ICPC
Limited function/disability (L)
2.8
8.6
51
216
M03BC01
ATC
orphenadrine (citrate); systemic
3.1
8.6
40
148
N06CA01
ATC
amitriptyline and psycholeptics; systemic
4.2
8.5
24
63
S22.0
ICD-10 Finland
Fracture of thoracic vertebra
13.6
8.5
14
11
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.8
8.5
53
231
M47.9
ICD-10 Finland
Spondylosis, unspecified
+∞
8.4
8
*
L04AX03
ATC
methotrexate; systemic
3.7
8.2
28
85
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
3.8
8.1
27
80
M05BB03
ATC
alendronic acid and colecalciferol; oral
9.1
8.0
16
19
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.7
8.0
50
218
R03AC02
ATC
salbutamol; inhalant
2.4
7.7
121
798
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.5
7.7
65
327
L76
ICPC
Fracture: other
7.0
7.6
18
28
X58
ICD-10 Finland
Exposure to other specified factors
2.9
7.5
40
159
L86
ICPC
Back syndrome with radiating pain
8.9
7.5
15
18
NAG62
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, 2-3 vertebraea
83.1
7.5
8
*
G55.1*M51.1
ICD-10 Finland
Compression of nerve roots and nerve plexus in disc diseases in the lumbar region and other regions
83.1
7.5
8
*
H02AB06
ATC
prednisolone; systemic
2.3
7.5
95
571
A01
ICPC
Pain general/multiple sites
3.4
7.4
28
91
AA1AD
NOMESCO Finland
CT of head and brain
2.4
7.2
67
351
M70.6
ICD-10 Finland
Trochanteric bursitis
3.1
7.0
31
111
M19.0
ICD-10 Finland
Primary arthrosis of other joints
3.6
7.0
24
73
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.3
6.9
80
458
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
11.5
6.9
12
11
A02BC02
ATC
pantoprazole; systemic
2.3
6.8
126
872
M79.6
ICD-10 Finland
Pain in limb
2.2
6.8
91
553
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.3
6.7
76
431
B01AB05
ATC
enoxaparin; parenteral
2.3
6.6
66
354
SPAT1254
SPAT
Administration of medicine
2.6
6.6
44
196
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.7
6.6
40
170
TPH04
NOMESCO Finland
Cathetrisation of vein
2.5
6.6
50
238
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.0
6.5
19
51
SPAT1212
SPAT
Extensive examination of musculoskeletal system
3.7
6.5
21
61
R03DC03
ATC
montelukast; oral
2.7
6.5
39
165
M48.5
ICD-10 Finland
Collapsed vertebra, not elsewhere classified
72.1
6.5
7
*
NE1AD
NOMESCO Finland
Pelvis and hip bones CT examination
8.6
6.4
13
16
M54.3
ICD-10 Finland
Sciatica
8.6
6.4
13
16
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
11.6
6.4
11
10
Z01.8
ICD-10 Finland
Other specified special examinations
2.5
6.4
49
234
SPAT1203
SPAT
Injection therapy, other than intramuscular or subcutaneous
7.5
6.3
14
20
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
6.3
99
636
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
+∞
6.3
6
*
G55.2*M47.9
ICD-10 Finland
Nerve root and plexus compressions in spondylosis
+∞
6.3
6
*
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
27.7
6.3
8
*
S32.1
ICD-10 Finland
Fracture of sacrum
27.7
6.3
8
*
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
3.3
6.2
25
84
A28
ICPC
Limited function/disability NOS
2.4
6.2
53
266
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.9
6.1
31
120
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
137
884
2.87
10.34
8.2
8.2
1.20
1.22
mmol/l
1.37
124
787
118
749
2.47
8.52
3.1
2.8
78.14
75.09
nmol/l
0.51
106
673
74
383
2.51
8.35
2.6
2.4
—
—
—
0
0
44
182
2.83
7.71
7.2
10.2
12.12
12.96
kpa
0.53
44
177
156
1169
2.71
7.27
5.6
4.1
13.52
12.28
mm/h
0.35
143
1075
28
99
3.14
6.42
6.4
15.3
93.39
95.12
%
0.88
28
99
29
105
3.07
6.39
6.2
14.4
0.62
0.65
%
0.16
29
105
109
727
2.14
6.27
5.4
5.1
35.48
35.75
g/l
0.21
104
683
29
107
3.01
6.18
6.1
14.2
1.54
1.19
%
0.82
29
107
133
969
2.18
5.95
10.5
10.6
3.90
3.90
e9/l
0.00
116
834
59
321
2.20
5.62
4.0
3.0
2.45
2.47
mmol/l
0.50
50
292
50
260
2.24
5.28
1.8
1.6
1108.64
1156.41
nmol/l
0.14
37
194
64
371
2.08
5.12
2.4
3.4
321.56
344.26
umol/l
1.05
52
332
150
1182
2.19
5.00
10.3
7.2
83.22
89.98
u/l
0.79
144
1108
26
106
2.68
4.61
1.8
1.6
—
—
—
0
0
39
193
2.28
4.60
1.9
1.7
—
—
—
0
0
101
708
1.89
4.54
3.4
2.7
—
—
estimate
—
0
0
8
10
8.28
4.10
1.3
1.3
—
—
—
0
0
47
262
2.05
4.09
2.2
1.8
—
—
—
0
0
12
27
4.67
4.01
1.5
1.5
—
—
—
0
0
12
27
4.67
4.01
1.5
1.5
—
—
—
0
0
13
33
4.15
3.88
1.4
1.1
—
—
—
0
0
82
559
1.81
3.87
5.1
4.0
39.53
47.25
ng/l
0.18
57
410
85
586
1.80
3.86
3.6
3.1
2.33
2.37
mmol/l
2.14
73
538
74
495
1.80
3.68
4.6
3.7
0.18
0.43
e6/l
2.17
59
360
13
36
3.79
3.57
4.8
2.7
2.66
2.91
ratio
—
8
19
45
261
1.94
3.47
1.3
1.3
24.14
37.83
iu/ml
—
8
86
125
983
1.76
3.47
3.5
3.1
—
—
—
0
0
35
188
2.05
3.34
2.0
1.8
—
—
—
0
0
70
472
1.76
3.33
2.5
2.5
2.39
2.80
mg/l
1.15
62
409
6
7
8.79
3.28
2.7
2.9
43.27
265.96
ug/l
—
6
7
14
49
3.00
3.26
3.4
3.3
0.00
1.97
index
—
6
32
17
67
2.68
3.22
1.0
1.2
—
—
—
0
0
175
1555
2.28
3.03
27.4
15.1
25.40
24.57
mg/l
0.10
151
1244
92
684
1.66
2.98
2.5
2.0
89.09
95.49
pmol/l
0.60
57
339
21
96
2.33
2.96
2.0
1.7
—
—
—
0
0
40
237
1.87
2.87
5.6
9.6
104.77
104.58
mmol/l
0.09
40
237
15
59
2.67
2.86
1.4
1.3
—
—
—
0
0
71
503
1.65
2.73
3.2
4.0
1688.37
1395.46
ng/l
0.21
62
441
39
233
1.84
2.73
1.4
1.3
7.37
11.56
u/ml
0.21
16
76
17
74
2.42
2.66
1.2
1.2
—
—
—
0
0
21
102
2.19
2.58
1.3
1.3
406.88
252.24
u/ml
0.25
21
96
5
8
6.38
2.38
1.8
2.3
684.20
1222.38
u/ml
—
5
8
104
829
1.55
2.34
4.9
4.0
0.00
0.00
estimate
-0.00
15
184
10
34
3.04
2.32
1.3
1.1
—
—
—
0
0
6
13
4.72
2.29
1.7
1.6
—
—
—
0
0
104
832
1.54
2.28
4.9
4.0
0.00
0.01
estimate
0.50
15
187
7
18
3.99
2.27
1.6
1.7
13.67
17.85
ug/l
—
7
18
11
41
2.78
2.25
1.0
1.1
—
—
—
0
0
22
117
1.99
2.17
2.3
2.5
4.36
5.72
ug/l
0.72
16
103
6
14
4.39
2.16
1.7
1.6
—
—
—
0
0
6
14
4.39
2.16
1.8
1.6
—
—
—
0
0
6
14
4.39
2.16
1.7
1.6
—
—
—
0
0
6
14
4.39
2.16
1.8
1.6
—
—
—
0
0
6
14
4.39
2.16
1.8
1.6
—
—
—
0
0
24
132
1.93
2.15
3.6
3.7
322.04
271.38
ng/l
0.17
24
125
11
43
2.65
2.12
1.0
1.1
—
—
—
0
0
7
20
3.59
2.07
3.3
3.1
—
—
—
0
0
96
771
1.49
1.98
3.5
3.1
107.60
104.96
ug/l
0.06
84
716
103
843
1.47
1.91
5.0
4.1
0.00
0.02
estimate
0.50
15
177
29
177
1.75
1.90
4.4
4.9
13.15
9.18
ug/l
0.18
24
147
45
311
1.58
1.85
4.2
3.2
0.42
1.18
e6/l
2.01
24
171
62
463
1.50
1.79
2.2
1.7
17.85
20.80
nmol/l
0.92
55
388
141
1237
1.51
1.78
5.2
4.3
14.83
14.92
pmol/l
0.15
131
1127
114
960
1.45
1.77
4.2
3.6
46.48
44.89
u/l
0.11
107
905
43
297
1.58
1.77
4.3
7.4
1.09
1.16
mmol/l
0.92
38
277
6
18
3.40
1.76
1.0
1.3
—
—
—
0
0
44
306
1.57
1.76
4.3
3.2
1.82
2.87
e6/l
0.50
22
171
62
465
1.49
1.75
1.5
1.8
1.31
3.16
u/ml
1.09
16
94
10
40
2.58
1.69
1.5
2.1
—
—
—
0
0
8
31
2.65
1.68
1.3
1.2
—
—
—
0
0
5
14
3.64
1.62
1.0
1.3
—
—
—
0
0
8
32
2.56
1.61
1.1
1.3
—
—
—
0
0
13
64
2.11
1.58
1.5
1.8
—
—
—
0
0
19
108
1.84
1.57
1.2
1.3
328.83
184.48
u/ml
—
6
44
8
33
2.48
1.55
1.4
5.2
4.90
9.72
pmol/l
—
8
33
7
28
2.55
1.46
1.1
1.3
—
—
—
0
0
29
191
1.61
1.45
3.4
14.0
24.96
24.69
mmol/l
0.15
29
191
5
16
3.18
1.44
3.2
3.7
2.38
4.19
nmol/l
—
5
16
5
16
3.18
1.44
1.0
1.3
—
—
—
0
0
5
16
3.18
1.44
1.0
1.3
—
—
—
0
0
5
16
3.18
1.44
1.0
1.3
—
—
—
0
0
11
53
2.14
1.41
1.5
1.3
—
—
—
0
0
9
41
2.25
1.39
1.8
1.3
—
—
—
0
0
45
331
1.47
1.38
7.1
3.7
42.13
437.96
ng/l
2.94
39
260
160
1468
1.51
1.38
6.5
5.3
1.98
1.98
mu/l
0.01
151
1346
0
40
0.00
1.34
0.0
1.1
—
64.30
—
0
10
10
49
2.10
1.24
4.9
3.7
3.65
4.04
mmol/l
—
10
49
5
19
2.67
1.22
1.0
1.2
—
—
—
0
0
5
20
2.54
1.16
1.2
1.2
—
—
—
0
0
5
21
2.42
1.09
1.2
1.2
—
—
—
0
0
172
1627
1.50
1.00
15.1
11.3
22.23
24.47
u/l
1.84
164
1574
5
23
2.20
0.98
1.2
1.1
—
—
—
0
0
7
36
1.98
0.98
3.4
1.7
—
—
—
0
0
6
27
2.26
0.94
1.5
1.1
—
—
—
0
0
45
361
1.32
0.84
6.0
3.9
1.02
1.02
kg/l
0.00
37
239
8
47
1.73
0.81
3.4
1.9
—
—
—
0
0
134
1437
0.78
0.81
5.1
5.0
4.40
4.51
mmol/l
0.61
124
1335
6
34
1.79
0.77
1.5
1.4
—
—
—
0
0
22
160
1.42
0.74
4.7
4.8
31.29
33.09
%
0.41
17
99
43
349
1.30
0.74
1.8
1.8
—
—
—
0
0
54
454
1.26
0.71
5.3
4.0
0.00
0.01
estimate
0.50
12
171
38
306
1.30
0.69
2.8
4.4
22.74
21.72
%
0.10
17
161
54
629
0.80
0.66
1.9
1.9
1.31
1.25
mmol/l
0.12
41
521
28
218
1.33
0.65
2.4
3.0
0.70
0.74
ug/l
0.07
20
152
21
156
1.39
0.64
11.0
6.1
—
—
—
0
0
6
101
0.58
0.64
2.5
14.5
1.21
1.31
mg/l
—
6
94
8
53
1.53
0.59
3.3
1.9
—
—
—
0
0
39
323
1.26
0.58
1.5
1.8
484.18
44656951.90
pmol/l
0.50
28
262
135
1428
0.82
0.58
5.2
4.8
1.50
1.49
mmol/l
0.10
126
1319
44
377
1.22
0.49
5.9
5.3
2.21
2.97
ug/l
0.34
39
344
9
127
0.69
0.45
1.0
1.1
—
—
—
0
0
16
122
1.34
0.44
1.8
1.4
—
—
—
0
0
11
150
0.72
0.43
2.5
2.5
0.47
0.87
e6/l
0.28
11
141
14
105
1.36
0.42
1.9
3.4
67.57
55.50
ml/min/173m2
—
7
46
0
17
0.00
0.41
0.0
1.7
—
—
—
0
0
45
506
0.86
0.37
4.2
4.2
21.49
8.68
mg/mmol
0.38
28
343
68
621
1.15
0.36
5.6
4.0
0.00
0.08
estimate
1.48
14
156
19
155
1.25
0.34
4.5
3.2
—
—
—
0
0
143
1379
1.14
0.31
26.1
15.2
80.46
78.50
ml/min/173m2
0.47
135
1238
17
203
0.82
0.27
1.6
1.5
—
—
—
0
0
143
1469
0.90
0.23
5.6
5.6
2.48
2.60
mmol/l
1.04
132
1357
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
6
48
1.26
0.20
1.5
1.3
—
—
—
0
0
6
49
1.23
0.20
1.5
1.4
—
—
—
0
0
21
187
1.14
0.16
5.6
8.6
9.84
8.25
mmol/l
0.46
21
175
49
461
1.08
0.15
4.8
3.7
0.00
0.01
estimate
0.50
13
147
142
1443
0.94
0.11
5.3
4.9
5.74
5.99
mmol/l
1.79
128
1312
11
96
1.15
0.10
2.3
7.9
0.68
0.59
%
0.53
11
96
5
44
1.14
0.10
1.6
1.9
—
—
—
0
0
5
44
1.14
0.10
1.2
2.9
552.80
432.86
mg/l
—
5
44
6
55
1.09
0.09
2.2
2.0
—
—
—
0
0
6
55
1.09
0.09
1.0
1.2
—
11.43
—
0
12
5
63
0.79
0.08
1.6
4.2
26.98
24.86
mmol/l
—
5
63
16
148
1.09
0.06
2.2
1.9
—
—
—
0
0
15
161
0.93
0.05
2.5
2.1
—
—
—
0
0
134
1354
0.97
0.05
4.3
4.2
1.20
1.21
mmol/l
0.08
124
1240
138
1391
0.97
0.03
6.5
6.7
39.03
39.94
mmol/mol
0.60
128
1307
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
203.00
—
0
5
0
7
0.00
-0.00
0.0
3.0
—
43.36
—
0
7
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
6.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
85
0.94
-0.00
1.1
2.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
10.8
—
—
—
0
0
9
94
0.96
-0.00
1.6
2.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_FATIGFRACT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_FATIGFRACT | 1.518 [1.15, 2.0] | 0.003 |
| Birth year | 0.996 [0.99, 1.0] | 0.403 |
During the follow-up period (1.1.1998 — 31.12.2019), 179 out of 579 females with M13_FATIGFRACT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_FATIGFRACT | 1.865 [1.31, 2.66] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 109 out of 387 males with M13_FATIGFRACT died.
Mortality risk
Mortality risk for people of age
years, who have M13_FATIGFRACT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.183% | 0.329% |
| 5 | 0.973% | 1.964% |
| 10 | 2.401% | 4.885% |
| 15 | 4.479% | 8.956% |
| 20 | 7.785% | 15.13% |
Relationships between endpoints
↥Index endpoint: M13_FATIGFRACT – Fatigue fracture of vertebra
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data