Hypertrophy of bone

M13_BONEHYPERTRPH

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M89.3 Cause of death: ICD-10 — M89.3 2 out of 7 registries used, show all original rules.	131
4. Check minimum number of events None	131
5. Include endpoints None	131
6. Filter based on genotype QC (FinnGen only)	119

Control definitions (FinnGen only)

Control exclude: M13_OSTEOCHONDRO

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: M89
Name in latin: Hypertrophia ossis

NAME	M13_BONEHYPERTRPH
CONTROL_EXCLUDE	M13_OSTEOCHONDRO
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M893
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M893
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Hypertrophy of bone based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	932	474	453
Only index persons	900	464	436
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	41.88	43.81	40.03
Only index persons	41.76	43.39	40.02

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	119	74	45
Unadjusted period prevalence (%)	0.02	0.03	0.02
Median age at first event (years)	43.29	40.79	47.41

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
122: Matched controls
1220

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M89.3

ICD-10 Finland

Hypertrophy of bone

+∞

176.1

122

NHK10

NOMESCO Finland

Incision or excision of metatarsal or tarsal bone

111.5

18.1

NHK99

NOMESCO Finland

Other operation on bone of ankle or foot

26.4

16.2

SPAT1156

SPAT

Guidance concerning treatment of rash and skin

4.5

7.8

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3002256) Pathology report gross observation

122

2.56

4.04

1.2

—

(3042936) Bacteria identified in Isolate by Culture

144

2.33

3.53

2.1

1.5

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

498

1.95

3.22

2.8

2.5

—

estimate

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

4.14

2.83

1.2

1.5

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

237

1.95

2.79

1.6

1.3

42.87

29.51

iu/ml

0.25

(3007853) Bacteria identified in Skin by Aerobe culture

113

2.16

2.45

2.9

1.6

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

628

1.80

2.40

12.6

10.6

4.13

3.94

e9/l

0.25

556

(3023511) Choriogonadotropin [Units/volume] in Urine

3.39

2.36

2.0

1.1

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

218

1.85

2.28

1.7

1.3

8.49

6.50

u/ml

0.10

(3026389) Candida sp identified in Specimen by Organism specific culture

5.74

2.23

1.2

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.78

2.21

1.7

2.1

—

(3019309) Folate [Moles/volume] in Red Blood Cells

133

2.00

2.19

1.6

1.5

984.67

1177.06

nmol/l

0.83

(3032080) INR in Blood by Coagulation assay

416

1.69

2.14

14.4

9.5

1.17

inr

0.00

338

(3018418) pH of Serum or Plasma

287

1.71

1.98

6.2

4.2

7.40

7.39

0.58

200

(3044640) Blood type and Crossmatch panel - Blood

334

1.66

1.90

2.9

2.2

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

117

1.96

1.89

1.7

1.5

—

(3037756) Immunofixation for Serum or Plasma

3.65

1.86

5.8

1.4

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

4.29

1.84

1.4

—

(3025130) Human papilloma virus identified in Specimen

2.88

1.82

1.5

2.0

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

784

1.71

1.75

3.3

3.4

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

252

1.67

1.74

1.9

2.0

2.46

2.80

mg/l

0.41

222

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

2.56

1.69

1.5

1.3

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

2.56

1.69

1.7

1.8

36.60

40.29

nmol/l

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

426

1.58

1.68

2.1

1.9

93.49

95.66

pmol/l

0.13

225

(3021960) Folate [Moles/volume] in Serum or Plasma

272

1.64

1.67

1.7

1.6

18.10

20.73

nmol/l

0.71

233

(3019150) Specific gravity of Urine by Refractometry

246

1.66

1.67

6.3

3.1

1.02

kg/l

0.87

157

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.50

1.66

1.2

1.3

—

(3035350) Ketones [Presence] in Urine by Test strip

562

1.58

1.66

5.0

3.4

0.00

estimate

-0.00

108

(3023368) Bacteria identified in Blood by Culture

247

1.65

1.64

4.2

3.8

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

116

1.87

1.61

1.8

1.5

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

2.02

1.57

2.1

1.5

—

(3017446) Testosterone [Moles/volume] in Serum or Plasma

102

1.90

1.55

1.9

2.5

11.84

14.50

nmol/l

0.74

(3006315) Basophils [#/volume] in Blood

578

1.55

1.54

10.9

6.4

0.04

e9/l

0.29

506

(3021788) Differential panel - Synovial fluid

3.43

1.54

1.4

1.3

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

159

1.72

1.50

1.7

—

(3029937) Albumin [Presence] in Urine by Test strip

298

1.57

1.46

5.5

3.4

0.00

estimate

-0.00

101

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

465

1.52

1.46

9.7

6.8

1.21

mmol/l

0.03

407

(3044941) Cell count panel - Synovial fluid

3.21

1.45

1.2

1.3

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

3.21

1.45

2.4

1.9

—

(3019198) Lymphocytes [#/volume] in Blood

583

1.52

1.45

11.0

6.5

2.07

1.87

e9/l

1.29

523

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

2.35

1.43

8.8

5.0

2.69

1.61

—

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

2.18

1.43

2.9

1.4

45.44

39.98

u/l

0.34

(40758558) Short blood count panel - Blood

318

1.54

1.42

6.5

6.1

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

2.50

1.41

1.0

1.4

—

(3001604) Monocytes [#/volume] in Blood

575

1.51

1.41

11.1

6.4

0.55

e9/l

0.03

503

(3021601) Nitrite [Presence] in Urine by Test strip

558

1.49

1.36

4.9

3.4

0.00

estimate

-0.00

110

(3009261) Glucose [Presence] in Urine by Test strip

569

1.49

1.34

5.1

3.4

0.00

estimate

-0.00

101

(40768797) Stomach Pathology biopsy report

140

1.70

1.32

1.2

—

(3026008) Bacteria identified in Urine by Culture

278

1.53

1.30

4.1

2.4

—

(3043409) Potassium [Moles/volume] in Arterial blood

2.85

1.30

3.0

3.6

3.74

3.95

mmol/l

—

(3007930) Methemoglobin/Hemoglobin.total in Blood

2.37

1.29

9.5

5.5

0.95

0.91

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

192

1.59

1.26

4.5

2.8

33.74

157.46

ng/l

1.17

118

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

114

1067

2.04

1.25

18.7

12.6

24.44

21.81

mg/l

0.42

100

853

(3013707) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method

833

1.56

1.24

7.1

4.1

8.74

9.39

mm/h

0.26

780

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.12

1.17

1.3

1.2

—

(3015171) Extractable nuclear Ab [Units/volume] in Serum

2.12

1.17

1.1

1.3

—

(3013115) Eosinophils [#/volume] in Blood

599

1.44

1.16

10.8

6.7

0.18

0.19

e9/l

0.26

531

(40768804) Tissue Pathology biopsy report

435

1.43

1.13

2.4

2.0

—

(3025941) Bacteria identified in Stool by Culture

1.95

1.11

1.2

—

(1616796) Gas panel - Central venous blood

2.44

1.10

2.4

1.5

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

271

1.47

1.06

1.4

1.7

—

(3019069) Monocytes/Leukocytes in Blood

528

1.40

1.03

11.1

6.3

8.51

8.50

0.01

505

(3006504) Eosinophils/Leukocytes in Blood

528

1.40

1.03

11.1

6.2

2.68

2.87

0.32

501

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

1.75

1.03

2.1

2.6

0.22

g/l

0.10

(3037522) Nuclear Ab [Titer] in Serum

167

1.54

1.02

1.7

1.4

330.00

603.90

titre

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.90

1.01

1.7

1.6

—

(3010726) Horse dander IgE Ab [Units/volume] in Serum

0.00

0.98

0.0

1.1

—

0.73

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

231

1.46

0.96

1.3

1.7

0.52

1.12

mg/l

1.23

183

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

1.77

0.92

2.7

4.5

62.83

79.00

ng/l

0.66

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

252

1.42

0.90

2.5

2.3

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

105

1.60

0.87

1.9

2.0

—

(3022096) Basophils/Leukocytes in Blood

529

1.35

0.86

11.3

6.2

0.73

0.71

0.14

499

(40760892) CBC W Ordered Manual Differential panel - Blood

274

1.39

0.83

5.5

5.3

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

1.92

0.83

1.0

1.3

—

(3019060) Gas panel - Arterial blood

1.75

0.82

3.9

3.7

—

(3018095) Leukocytes [#/volume] in Urine

387

1.35

0.82

5.4

3.5

12.54

38.77

e6/l

1.32

250

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.69

0.81

1.2

1.3

—

(3021589) Normoblasts [#/volume] in Blood

494

1.33

0.80

12.8

10.4

0.00

e9/l

-0.00

401

(3014133) Dog dander IgE Ab [Units/volume] in Serum

0.00

0.80

0.0

1.0

—

3.55

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.80

0.0

1.1

—

(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.80

0.0

1.2

—

4.75

—

(3023430) Cat dander IgE Ab [Units/volume] in Serum

0.00

0.80

0.0

1.1

—

11.22

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.76

0.78

1.2

1.3

—

(3002582) Erythrocytes [#/volume] in Urine

325

1.34

0.75

4.2

3.0

12.78

35.36

e6/l

1.78

238

(3002523) Influenza virus A Ag [Presence] in Specimen

2.04

0.73

1.0

1.2

—

(3003740) Influenza virus B Ag [Presence] in Specimen

2.04

0.73

1.0

1.2

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

2.04

0.73

2.2

2.0

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

422

1.31

0.72

4.9

3.2

0.00

estimate

-0.00

(3008898) HLA-B27 [Presence]

1.70

0.71

1.0

1.1

—

(3020682) Albumin/Creatinine [Ratio] in Urine

320

1.32

0.68

3.3

3.7

1.54

10.76

mg/mmol

2.90

208

(4024509) Urine culture

1.68

0.63

2.5

1.5

—

(3019832) Treponema pallidum Ab [Presence] in Serum

176

1.38

0.62

1.7

1.8

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

410

1.28

0.62

7.0

4.2

36.06

36.59

g/l

0.34

391

(3010130) Cytomegalovirus IgG Ab [Units/volume] in Serum or Plasma

1.69

0.62

1.0

1.2

—

168.33

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

1.69

0.62

1.2

1.1

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

1.69

0.62

1.2

—

(3000492) Spirometry study

111

0.61

2.6

1.4

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

0.61

0.0

2.6

—

58.58

—

(3012516) Albumin [Mass/volume] in Urine

317

1.29

0.58

3.1

3.2

16.89

53.49

mg/l

2.37

211

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.70

0.57

1.0

1.2

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.61

0.55

1.2

1.3

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.46

0.53

2.1

1.9

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

818

1.27

0.53

9.2

7.5

72.72

75.78

u/l

0.45

764

(3019977) pH of Arterial blood

101

1.44

0.52

12.9

8.6

7.43

7.42

—

(40761511) CBC panel - Blood by Automated count

115

1114

1.56

0.51

16.4

11.1

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

296

1.26

0.48

2.0

2.1

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

104

1.39

0.45

12.8

8.4

4.82

5.02

kpa

0.39

(42870588) Differential panel, method unspecified - Blood

356

1.23

0.44

11.2

6.0

—

(4034850) Laboratory test

1.64

0.43

6.8

6.1

—

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

1.64

0.43

3.0

1.2

9.92

9.44

mg/l

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

215

1.27

0.43

1.8

1.5

—

(4062490) Immunoglobulin typing, IgG

0.00

0.41

0.0

1.5

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.41

0.0

9.7

—

943.33

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.38

0.41

4.2

5.8

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

105

1007

1.31

0.41

6.1

5.4

2.07

1.84

mu/l

0.87

945

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.9

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.41

0.0

12.5

—

1700.47

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.41

0.0

4.0

—

55.35

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

1.49

0.41

1.4

1.5

66.62

47.10

ug/l

—

(3050129) First trimester maternal screen panel - Serum or Plasma

1.39

0.39

1.4

—

(36660697) Celiac disease serology panel - Serum

112

0.69

0.39

1.0

1.2

—

(3005136) Cladosporium herbarum IgE Ab [Units/volume] in Serum

0.00

0.39

0.0

1.1

—

0.05

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

116

1.33

0.39

13.5

8.1

103.20

104.50

mmol/l

0.32

116

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

1.41

0.38

1.8

1.7

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

164

1.26

0.35

4.0

2.8

1.18

2.97

e6/l

0.96

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

183

1.25

0.35

2.4

2.0

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

478

0.84

0.35

2.0

1.9

1.58

1.42

mmol/l

0.37

408

(3022145) Colonoscopy Study observation

143

0.75

0.34

1.5

1.4

—

(3009214) Lutropin [Units/volume] in Serum or Plasma

1.35

0.34

1.7

1.5

3.93

10.84

u/l

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

845

1.20

0.34

4.9

4.5

14.56

14.65

pmol/l

0.13

793

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

128

1.29

0.34

2.0

1.8

—

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

106

1024

1.27

0.33

17.7

12.6

86.31

87.68

ml/min/173m2

0.30

925

(3003694) ABO and Rh group [Type] in Blood

347

1.18

0.32

1.5

1.4

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.34

0.31

13.9

11.4

0.74

0.65

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

358

1.17

0.31

4.6

3.0

—

(1761868) Lipid panel - Serum or Plasma

483

0.86

0.29

2.8

—

(3028026) IgM [Mass/volume] in Serum or Plasma

1.34

0.29

4.2

1.8

0.82

1.61

g/l

—

(3030467) Casts [#/volume] in Urine by Automated count

293

1.17

0.28

3.9

2.8

0.13

0.48

e6/l

1.54

205

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

984

0.84

0.27

6.5

5.8

39.53

38.76

mmol/mol

0.33

943

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

180

1.20

0.26

3.4

2.9

0.62

0.71

ug/l

0.40

105

(40761535) Cells panel - Urine sediment

1.22

0.25

5.0

3.1

—

(1002224) Polysomnography panel

1.20

0.25

1.6

1.1

—

(40761536) Microorganisms panel - Urine sediment

0.72

0.25

4.5

3.4

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

200

1.18

0.24

2.3

2.2

—

(3002385) Erythrocyte [DistWidth] in Red Blood Cells

937

1.17

0.24

24.9

16.1

13.59

13.46

0.50

932

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

804

1.14

0.24

3.2

37.82

46.85

u/l

0.84

769

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

356

1.14

0.23

2.6

3.2

24.93

41.03

ng/l

0.50

218

(42529406) Shigella sp [Presence] in Stool by Culture

1.23

0.22

1.0

1.1

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

1.23

0.22

1.0

1.1

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.23

0.22

1.0

1.1

—

(3015736) pH of Urine

456

1.12

0.21

4.4

3.1

6.15

6.23

0.20

247

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.4

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.21

0.0

2.9

—

4.03

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.21

0.0

2.9

—

1.21

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.21

0.0

1.0

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.21

0.0

2.9

—

104.73

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

33.66

—

(3011951) Aspergillus fumigatus IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

0.07

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.21

0.0

1.2

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

4.0

—

2.50

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.8

—

14.64

—

(3011648) Oxygen content in Venous blood

0.00

0.21

0.0

1.8

—

11.52

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

2.1

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

156

1.18

0.20

1.8

2.3

2.43

2.32

g/l

0.31

138

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.24

0.20

4.7

2.8

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.19

0.19

14.5

3.2

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

234

1.14

0.18

5.1

4.2

20.91

22.39

0.17

102

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.22

0.18

12.6

10.7

1.19

1.61

—

(3016879) Cocaine [Presence] in Urine

0.72

0.17

2.0

1.5

—

(3027008) Opiates [Presence] in Urine

1.14

0.16

1.6

1.5

—

(3000764) Benzodiazepines [Presence] in Urine

1.14

0.16

1.6

1.5

—

(3028300) Cannabinoids [Presence] in Urine

1.14

0.16

1.6

1.5

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

178

1.15

0.16

1.9

1.5

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

103

1007

1.15

0.16

4.2

4.0

1.41

1.30

mmol/l

0.34

948

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.12

0.16

1.1

1.3

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

0.81

0.15

1.3

1.5

5.40

20.26

iu/l

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

180

1.13

0.14

4.0

2.7

0.36

0.73

e6/l

0.86

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

309

1.09

0.12

1.3

1.4

15.78

1.53

u/ml

—

(3041096) Erythrocytes [Presence] in Urine by Automated

311

1.08

0.10

4.0

2.8

0.00

estimate

-0.00

(3007164) IgA [Mass/volume] in Serum or Plasma

272

1.09

0.10

2.3

1.5

2.09

2.34

g/l

0.49

165

(3003327) Ova and parasites identified in Stool by Light microscopy

1.12

0.10

2.2

1.7

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

116

1.14

0.10

1.8

1.5

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

1.07

0.09

1.0

1.1

—

0.54

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.04

0.08

10.7

9.6

23.35

24.38

mmol/l

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.81

0.08

2.4

1.6

—

(3009343) pH of Capillary blood

0.77

0.08

2.2

2.8

7.41

—

(3000494) Fungus identified in Specimen by Culture

127

1.12

0.08

1.5

—

(3005719) IgG [Mass/volume] in Serum or Plasma

1.13

0.08

7.9

2.0

11.00

10.11

g/l

0.28

(3027944) Amphetamines [Presence] in Urine

1.10

0.08

1.6

1.5

—

(3000991) Gas panel - Venous blood

1.02

0.07

11.7

8.9

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

101

1023

0.93

0.07

5.7

4.6

5.77

5.88

mmol/l

0.45

962

(3013512) EKG study

327

1.06

0.05

3.1

3.2

—

(3014051) Protein [Presence] in Urine by Test strip

320

1.04

0.03

3.7

2.7

—

0.40

—

(3022948) Iron [Moles/volume] in Serum or Plasma

172

1.05

0.02

2.2

2.3

13.69

14.60

umol/l

0.27

156

(4035726) Immunohistochemistry procedure

1.03

0.00

1.1

1.3

—

(21494755) Public health laboratory ask at order entry panel

133

0.97

0.00

1.5

1.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

247

1.02

0.00

1.9

1.7

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

155

0.96

0.00

1.6

1.4

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

-0.00

0.0

2.1

—

(40758355) Pancreatic polypeptide [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

4.0

—

57.22

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.4

—

2.01

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

1.02

-0.00

1.0

1.1

1.06

0.89

g/l

—

(44817194) Complement alternate pathway AH50 actual/normal in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

88.67

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

-0.00

0.0

1.0

—

210.92

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

-0.00

0.0

1.0

—

(3012441) Differential panel - Pleural fluid

0.00

-0.00

0.0

1.2

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

-0.00

0.0

1.0

—

(3011436) Histone Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.3

—

(3025577) Chromium [Mass/volume] in Blood

0.00

-0.00

0.0

2.6

—

1.68

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

1126.00

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

-0.00

0.0

12.5

—

7.23

—

(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.0

—

124.40

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.1

—

(40760543) Extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.1

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

-0.00

0.0

1.5

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

-0.00

0.0

1.8

—

90.15

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

1.1

—

(3028433) Virus identified in Specimen by Culture

0.00

-0.00

0.0

1.8

—

(3009306) Alpha-1-Fetoprotein [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.8

—

8.38

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.1

—

(3005757) Coagulation factor V activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.0

—

106.71

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3048469) 10-Hydroxycarbazepine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.8

—

67.80

—

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

0.61

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

1129.80

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(40765096) Chromosome analysis panel by Banding

0.00

-0.00

0.0

1.6

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

0.00

-0.00

0.0

1.2

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

1.02

-0.00

1.0

1.1

1.42

1.51

g/l

—

(3023709) Somatotropin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

3.0

—

0.47

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3021387) Prolactin [Units/volume] in Serum or Plasma

0.90

-0.00

1.7

1.6

330.83

328.15

mu/l

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

-0.00

0.0

1.0

—

7.23

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.3

—

51.83

—

(3022058) Hepatitis B virus DNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.86

-0.00

1.4

—

(3044927) Protein electrophoresis panel - Urine

0.00

-0.00

0.0

1.1

—

(3037534) Parathyrin related protein [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

55.12

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.99

-0.00

1.0

—

(40758292) HTLV I+II Ab panel - Serum

0.00

-0.00

0.0

1.5

—

Mortality – FinRegistry

↥

Association

Association between endpoint M13_BONEHYPERTRPH and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have M13_BONEHYPERTRPH.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: M13_BONEHYPERTRPH – Hypertrophy of bone

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Hypertrophy of bone

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints