cholinergic urticaria: a type of physical urticarias (or hives) that appears when a person is sweating.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
207 |
4. Check minimum number of eventsNone |
207 |
5. Include endpointsNone |
207 |
6. Filter based on genotype QC (FinnGen only) |
186 |
Control definitions (FinnGen only)
- Control exclude
- L12_URTICARIAERYTHEMA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L50
- Name in latin
- Urticaria cholinergica
Similar endpoints
↥List of similar endpoints to
Cholinergic urticaria
based on the number of shared cases.
Similar with more cases:
- Urticaria
- Urticaria and erythema
- Diseases of the skin and subcutaneous tissue
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1274 | 625 | 643 |
| Only index persons | 1222 | 606 | 616 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 28.90 | 35.86 | 22.06 |
| Only index persons | 28.80 | 35.69 | 22.03 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 186 | 112 | 74 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.03 |
| Median age at first event (years) | 37.48 | 43.65 | 28.14 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 192
- Matched controls
- 1920
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L50.5
ICD-10 Finland
Cholinergic urticaria
+∞
232.6
173
*
L50.9
ICD-10 Finland
Urticaria, unspecified
31.4
63.9
44
18
XQ800
NOMESCO Finland
Prick test
11.2
45.3
56
68
L50.3
ICD-10 Finland
Dermatographic urticaria
275.0
43.9
43
*
R06AE09
ATC
levocetirizine; oral
7.9
42.0
79
157
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
7.8
34.1
57
98
C01CA24
ATC
epinephrine; parenteral
8.9
32.1
46
66
R03DC03
ATC
montelukast; oral
6.0
31.5
77
192
L50.0
ICD-10 Finland
Allergic urticaria
47.1
29.2
35
9
L50.8
ICD-10 Finland
Other urticaria
326.5
28.6
28
*
R06AX27
ATC
desloratadine; oral
4.7
25.7
109
416
R06AE07
ATC
cetirizine; oral
5.2
25.4
139
642
R06AX22
ATC
ebastine; oral
4.6
21.5
71
219
L50.2
ICD-10 Finland
Urticaria due to cold and heat
234.4
21.0
21
*
T78.4
ICD-10 Finland
Allergy, unspecified
8.9
21.0
28
36
L50.1
ICD-10 Finland
Idiopathic urticaria
58.6
18.4
21
*
7085A
ICD-9 Finland
Urticaria, Cholinergic urticaria
+∞
18.0
17
*
N05BB01
ATC
hydroxyzine; systemic
6.8
16.1
27
45
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
4.4
15.5
46
128
H02AB06
ATC
prednisolone; systemic
3.3
14.4
117
621
R06AX13
ATC
loratadine; oral
3.7
13.8
55
188
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
3.3
12.1
59
228
L20.0
ICD-10 Finland
Besnier prurigo
4.1
11.4
35
99
J45
ICD-10 Finland
Asthma
4.0
11.2
36
105
D07AC01
ATC
betamethasone; topical
2.8
11.0
88
445
XQ810
NOMESCO Finland
Physical test for urticaria
+∞
10.5
10
*
D07AB08
ATC
desonide; topical
3.6
10.3
38
122
R06AX26
ATC
fexofenadine; oral
4.2
10.0
29
78
J45.0
ICD-10 Finland
Predominantly allergic asthma
3.7
9.9
35
109
D07AB02
ATC
hydrocortisone butyrate; topical
2.7
9.8
77
381
XQ802
NOMESCO Finland
Epicutan test
8.3
9.7
21
28
D07AC13
ATC
mometasone; topical
2.7
9.6
69
326
344
Kela drug reimbursment
Omalizumab
+∞
9.4
9
*
A02BA02
ATC
ranitidine; systemic
3.2
9.3
44
165
E000001, ,
ATC
2.8
9.0
56
244
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
25.4
9.0
12
5
H04.10
ICD-10 Finland
Dry eye syndrome
3.3
9.0
38
133
R03DX05
ATC
omalizumab; parenteral
+∞
8.4
8
*
L50
ICD-10 Finland
Urticaria
10.7
8.2
15
15
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.4
8.2
87
489
J45.9
ICD-10 Finland
Asthma, unspecified
2.7
7.9
52
232
R96
ICPC
Asthma
3.6
7.8
28
88
R03AC02
ATC
salbutamol; inhalant
2.4
7.6
125
842
E0000UV, ,
ATC
2.3
7.5
97
587
D02AE01
ATC
carbamide; topical
4.5
7.5
19
46
R03BA08
ATC
ciclesonide; inhalant
3.1
6.3
28
100
L40.5
ICD-10 Finland
Arthropathic psoriasis
10.5
6.1
11
11
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
19
42
4.91
8.32
1.3
1.1
3.81
3.78
u/ml
0.00
13
26
31
118
2.94
6.27
1.1
1.3
113.43
141.87
u/ml
—
7
51
31
124
2.79
5.72
1.6
1.4
—
—
—
0
0
156
1253
2.31
4.97
6.3
4.1
10.03
9.86
mm/h
0.05
150
1171
94
651
1.87
4.35
4.5
6.9
1.22
1.22
mmol/l
0.64
89
612
77
513
1.84
3.94
2.6
3.0
—
—
—
0
0
115
870
1.80
3.82
3.4
3.5
0.00
0.00
estimate
-0.00
26
185
59
365
1.89
3.79
1.7
1.6
0.72
1.04
mg/l
0.75
40
281
116
881
1.80
3.79
3.4
3.5
0.00
8.68
estimate
0.50
26
187
64
407
1.86
3.77
2.9
2.8
0.10
0.22
e6/l
1.16
50
284
68
445
1.82
3.64
1.9
1.7
—
—
—
0
0
42
235
2.01
3.60
2.2
3.7
0.81
0.82
mmol/l
0.35
36
225
39
218
1.99
3.34
2.2
2.8
2.80
3.12
e6/l
0.07
20
93
123
977
1.72
3.19
10.0
10.2
3.50
3.95
e9/l
2.62
113
854
114
888
1.70
3.17
3.5
3.6
0.00
0.00
estimate
-0.00
24
176
98
734
1.68
3.15
5.7
7.5
1.22
1.21
mmol/l
0.53
88
641
89
658
1.66
2.95
2.2
1.9
97.20
97.63
pmol/l
0.03
42
346
41
247
1.84
2.80
2.1
2.7
0.27
0.83
e6/l
2.45
22
122
80
583
1.64
2.77
3.1
3.1
32.03
30.09
u/l
0.21
73
554
151
1295
1.78
2.72
5.9
4.3
15.10
14.59
pmol/l
1.99
142
1198
106
831
1.62
2.71
3.3
2.9
143.69
91.32
ug/l
0.54
98
794
89
673
1.60
2.61
3.2
3.3
0.00
0.01
estimate
0.50
22
153
12
42
2.98
2.60
1.0
1.2
3.40
3.76
mmol/l
1.08
12
37
77
565
1.61
2.55
3.3
3.5
26.60
21.26
ng/l
0.21
45
339
141
1205
1.64
2.37
9.7
8.1
75.61
76.78
u/l
0.17
136
1145
72
532
1.57
2.26
4.0
3.0
2.35
2.36
mmol/l
0.13
64
495
170
1537
1.93
2.23
7.1
5.1
1.70
1.84
mu/l
1.15
164
1443
14
61
2.40
2.20
2.0
1.6
—
—
—
0
0
20
102
2.07
2.20
1.1
1.0
—
—
—
0
0
48
325
1.64
2.16
1.4
1.3
1.18
9.53
u/ml
2.57
22
132
11
43
2.65
2.12
1.2
1.2
—
—
—
0
0
144
1252
1.60
2.10
3.2
3.5
—
—
—
0
0
12
50
2.49
2.07
2.0
2.0
147.00
177.76
%
1.05
12
50
12
51
2.44
1.99
1.2
1.2
—
—
—
0
0
9
33
2.81
1.96
1.1
1.1
—
—
—
0
0
45
308
1.60
1.93
2.6
2.4
—
—
—
0
0
50
356
1.55
1.81
1.5
1.3
11.91
22.59
iu/ml
1.56
16
121
142
1249
1.53
1.79
3.5
3.2
38.31
41.09
u/l
0.28
134
1201
5
13
3.92
1.72
1.0
3.2
56.80
97.00
nmol/l
—
5
13
35
232
1.62
1.70
2.0
2.3
2.26
2.40
g/l
0.81
29
215
61
461
1.47
1.66
1.8
1.3
2.40
2.05
u/ml
0.08
12
134
10
42
2.46
1.64
1.2
1.2
—
—
—
0
0
88
714
1.43
1.64
3.0
2.5
76.76
74.67
nmol/l
0.27
81
663
159
1443
1.59
1.64
19.8
16.1
13.25
13.42
%
1.25
159
1431
66
508
1.46
1.63
3.1
2.9
0.04
0.01
estimate
0.38
23
147
5
15
3.39
1.53
1.2
1.2
—
—
—
0
0
40
282
1.53
1.50
2.4
2.2
—
—
—
0
0
5
16
3.18
1.44
1.2
1.2
—
—
—
0
0
5
16
3.18
1.44
1.2
1.2
—
—
—
0
0
5
16
3.18
1.44
1.2
1.2
—
—
—
0
0
177
1663
1.82
1.43
16.2
13.4
13.37
21.21
mg/l
4.23
142
1330
56
428
1.44
1.42
1.8
1.5
19.55
20.53
nmol/l
0.22
45
371
10
48
2.14
1.30
1.1
1.1
—
1.20
—
0
7
5
19
2.67
1.22
1.4
1.5
—
—
—
0
0
38
278
1.46
1.20
3.4
3.2
236.81
573.73
ng/l
0.47
27
184
8
38
2.15
1.20
1.4
1.2
—
—
—
0
0
37
271
1.45
1.17
1.9
2.5
2.41
2.43
mmol/l
0.88
30
242
5
20
2.54
1.16
1.2
1.2
—
—
—
0
0
5
20
2.54
1.16
1.4
1.2
—
—
—
0
0
5
20
2.54
1.16
1.0
1.1
—
—
—
0
0
5
20
2.54
1.16
1.2
1.2
—
—
—
0
0
5
21
2.42
1.09
1.0
1.1
—
—
—
0
0
47
364
1.39
1.09
1.8
2.4
—
—
—
0
0
10
52
1.97
1.08
1.1
1.2
—
96.53
—
0
6
83
703
1.32
1.08
2.0
1.9
1.41
1.39
mmol/l
0.06
67
618
60
487
1.34
1.04
3.2
3.5
0.00
0.01
estimate
0.50
25
172
102
897
1.29
0.98
4.0
5.3
6.29
6.42
mmol/l
0.23
96
829
0
32
0.00
0.96
0.0
1.8
—
—
—
0
0
6
28
2.18
0.92
1.2
1.7
—
—
—
0
0
6
29
2.10
0.90
1.8
2.8
5.05
8.60
pmol/l
—
6
29
22
154
1.48
0.88
3.6
4.6
255.41
230.99
u/l
0.26
22
148
14
88
1.64
0.87
1.1
1.4
—
—
—
0
0
45
361
1.32
0.84
2.6
2.0
2.29
2.91
mg/l
1.67
35
326
6
32
1.90
0.82
1.2
1.7
—
—
—
0
0
8
47
1.73
0.81
1.8
2.7
—
—
—
0
0
11
66
1.71
0.80
1.5
1.3
—
—
—
0
0
14
92
1.56
0.74
1.4
1.6
—
—
—
0
0
5
26
1.95
0.71
1.4
2.0
6.52
5.12
u/ml
—
5
26
5
27
1.87
0.69
1.0
1.1
—
—
—
0
0
28
216
1.35
0.68
2.0
1.6
1120.62
1201.60
nmol/l
0.23
21
168
93
836
1.22
0.66
7.3
6.5
11.36
10.43
umol/l
0.58
87
791
165
1577
1.33
0.65
16.4
12.1
89.34
88.29
ml/min/173m2
0.26
150
1439
5
29
1.74
0.64
1.2
1.4
—
—
—
0
0
5
30
1.68
0.62
1.4
2.1
—
—
—
0
0
0
20
0.00
0.60
0.0
2.2
—
—
—
0
0
0
21
0.00
0.60
0.0
1.2
—
—
—
0
0
33
267
1.28
0.59
5.1
4.4
19.05
22.35
%
0.69
12
108
0
23
0.00
0.58
0.0
2.0
—
—
—
0
0
180
1750
1.46
0.56
20.9
16.3
73.53
74.16
umol/l
0.12
180
1731
6
37
1.64
0.56
1.2
1.4
—
—
—
0
0
12
84
1.46
0.50
1.3
2.7
0.60
0.66
%
0.25
12
84
7
47
1.51
0.48
2.3
1.5
—
—
—
0
0
12
85
1.44
0.48
3.5
8.8
26.32
25.35
mmol/l
0.53
12
85
13
175
0.72
0.47
1.7
1.7
—
—
—
0
0
47
409
1.20
0.45
2.9
3.4
1.02
1.02
kg/l
0.07
28
264
6
91
0.65
0.43
3.7
11.6
25.10
24.37
mmol/l
—
6
86
6
92
0.64
0.43
1.0
1.0
1.60
1.56
g/l
—
6
92
11
149
0.72
0.42
3.4
11.7
5.06
5.14
kpa
0.10
11
142
11
149
0.72
0.42
3.4
11.7
14.74
12.59
kpa
0.58
11
142
0
17
0.00
0.41
0.0
1.3
—
—
—
0
0
0
17
0.00
0.41
0.0
1.9
—
—
—
0
0
0
17
0.00
0.41
0.0
1.9
—
—
—
0
0
0
17
0.00
0.41
0.0
1.9
—
—
—
0
0
5
34
1.48
0.40
2.2
1.5
77.60
54.35
ug/l
—
5
34
5
34
1.48
0.40
1.0
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
82
755
1.15
0.40
2.4
2.7
—
—
estimate
—
0
0
44
386
1.18
0.39
3.2
3.1
994.18
885.86
ng/l
0.13
32
316
11
84
1.33
0.30
2.0
1.5
—
—
—
0
0
22
186
1.21
0.29
2.2
7.7
104.68
104.20
mmol/l
0.31
22
186
8
65
1.24
0.27
1.3
1.2
—
—
—
0
0
7
93
0.74
0.23
1.4
1.1
0.81
0.87
g/l
—
7
93
160
1566
1.13
0.21
5.3
4.4
5.68
5.77
mmol/l
0.36
148
1469
0
11
0.00
0.21
0.0
2.2
—
—
—
0
0
0
10
0.00
0.21
0.0
2.3
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
2.3
—
—
—
0
0
23
202
1.16
0.21
3.7
2.7
0.55
0.72
ug/l
1.06
18
114
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
2.1
—
—
—
0
0
0
12
0.00
0.21
0.0
2.1
—
—
—
0
0
0
12
0.00
0.21
0.0
2.1
—
—
—
0
0
0
12
0.00
0.21
0.0
2.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.7
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
107.41
—
0
13
22
249
0.87
0.20
1.6
1.9
—
—
—
0
0
0
14
0.00
0.20
0.0
4.1
—
874.79
—
0
14
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
16
186
0.85
0.20
1.7
1.7
—
—
—
0
0
6
50
1.21
0.20
2.7
1.6
—
—
—
0
0
15
174
0.85
0.18
4.3
6.0
—
—
—
0
0
36
332
1.10
0.17
1.3
1.4
—
—
—
0
0
166
1636
1.11
0.14
4.9
4.6
1.43
1.47
mmol/l
0.70
157
1543
16
141
1.15
0.14
4.8
2.9
—
—
—
0
0
18
164
1.11
0.10
3.3
1.8
361.33
394.32
nmol/l
0.41
18
152
158
1561
1.07
0.09
4.0
3.9
1.27
1.27
mmol/l
0.02
149
1459
166
1643
1.08
0.09
5.0
4.6
4.68
4.73
mmol/l
0.25
158
1559
6
73
0.82
0.07
2.0
1.3
—
—
—
0
0
16
147
1.10
0.07
4.3
2.3
—
—
—
0
0
45
467
0.95
0.07
3.8
4.3
8.92
7.75
mg/mmol
0.08
19
295
16
170
0.94
0.04
3.8
4.5
32.75
30.74
%
—
8
115
17
176
0.96
0.00
4.5
2.4
—
—
—
0
0
166
1666
0.97
0.00
5.8
5.1
2.80
2.80
mmol/l
0.00
157
1576
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
2.7
—
1.44
—
0
9
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
75
0.93
-0.00
1.6
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
57.07
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
69.40
—
0
5
0
5
0.00
-0.00
0.0
1.6
—
207.40
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
11
110
1.00
-0.00
3.8
7.7
11.32
8.50
mmol/l
0.39
11
104
7
70
1.00
-0.00
1.7
3.9
62.03
50.10
%
—
7
70
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
1713.83
—
0
6
6
69
0.87
-0.00
1.8
1.4
—
—
—
0
0
6
62
0.97
-0.00
1.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
10.29
—
0
5
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_URTICA_CHOLINERG and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have L12_URTICA_CHOLINERG.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: L12_URTICA_CHOLINERG – Cholinergic urticaria
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data